CN103908495A - Traditional Chinese medicine composition for improving postoperative immunity of cancer patient and preparation method of traditional Chinese medicine composition - Google Patents
Traditional Chinese medicine composition for improving postoperative immunity of cancer patient and preparation method of traditional Chinese medicine composition Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition for improving the postoperative immunity of a cancer patient. The traditional Chinese medicine composition is prepared from the main raw materials in parts by weight: 8-16 parts of lanceolata, 3-12 parts of radix cyathulae, 6-12 parts of ligustrum lucidum, 6-9 parts of poria cum lingo hospite, 6-14 parts of laminaria japonica, 20-35 parts of kudzu, 6-15 parts of Artemisia anomala, 6-15 parts of ligusticum wallichii, 6-12 parts of poria cocos, 3-6 parts of herba centellae, 2-8 parts of fructus psoralea (prepared with salts), 3-9 parts of toosandan fructus and 5-9 parts of pine pollen. The traditional Chinese medicine composition is definite in the curative effect, does not have any toxic and side effects and can be used for improving the immunity of the patient.
Description
Technical field
The present invention relates to Chinese medicine field, especially relate to a kind of Chinese medicine composition and method for making that improves tumor patient Postoperative Immunity function.
Background technology
Tumor, especially malignant tumor have a strong impact on people's life and health, for malignant tumor, generally adopt operative treatment, radiation treatment and chemotherapy.Radiotherapy, is the roentgenization tumor with various different-energies, to suppress and to kill a kind of Therapeutic Method of cancerous cell.Chemotherapy, is to treat malignant tumor by chemical substance, and chemotherapeutics, with whole body administration, can be attacked all cells of health, and be not only cancerous cell.Some chemotherapeutics are utilized separately for treatment cancer, but several drugs therapeutic alliance often.
Because chemotherapy is the differentiation that utilizes chemicals to kill the growth and breeding of tumor cell, inhibition tumor cell and promote tumor cell, heavy dose of chemicals is in killing tumor cell, also normal cell and immunity (opposing) cell together being killed, is the Therapeutic Method of a kind of " destruction of all people good and bad alike ".Radiotherapy chemotherapy, in treatment tumor, also can, to the side effect of human body generation, reduce the immunity of human body.These toxic and side effects main manifestations are, nausea and vomiting, alopecia, inappetence, headache and myalgia, malaise, bone marrow depression, anemia, thrombocytopenia, injury of lung, reproductive system damage, kidney and urinary injuries, liver dysfunction etc.These side effect have had a strong impact on the therapeutic effect of Radiotherapy chemotherapy, are even forced to stop treatment.
Malignant tumor belongs to that the traditional Chinese medical science " is amassed ", the category of " asthenia ", exists the performance of vital QI being weakened and pathogen being violent.And due to being continuous of the course of disease, can cause the phenomenon of " the kidney usually involved in chronic disease ".After accepting Radiotherapy chemotherapy, it is weakened body resistance, and disease is more obvious, because of further impaired causing of vigour: lethargy, malaise, dysphoria with feverish sensation in the chest palms and soles, say lazy language etc. less.Hinder and feel sick indigestion and loss of appetitely in stomach, hinder in dizziness and tinnitus of kidney, dedentition loss of hairs, soreness of waist foot is soft, hinders in shortness of breath and palpitation of the heart.Therefore, alleviate the toxic and side effects of Radiotherapy chemotherapy, improve patient's immunity, patient can better be received treatment, tool has very important significance.
Chinese medicine improving these reactions, improve aspect immunity of patient and have obvious advantage, but the new drug being really developed to not is a lot.Chinese medicine composition of the present invention is to consult on the basis of a large amount of TCM Document data and a large amount of clinical trials, the main pathogenesis of the toxicity producing for Radiotherapy chemotherapy and reduction patient immunity, in the treatment toxicity long-living by Radiotherapy chemotherapy, can also improve patient's immunity, strengthen patient's body constitution, patient can better be received treatment, avoid producing the phenomenon that stops treatment because of the side reaction of Radiotherapy chemotherapy.
Application publication number is CN103272116A(application number 201310197270.1) Chinese patent literature a kind of by name " adjusting the medicine of body immunity for radiation period " disclosed, this medicine is by the Radix Astragali 40～60, Radix Angelicae Sinensis 5～15, Radix Ophiopogonis 10～30, Radix Panacis Quinquefolii 1～3, Fructus Corni 5～15, Fructus Lycii 5～15, Radix Scrophulariae 5～15, Flos Chrysanthemi 5～10, Flos Carthami 5～10, monkey mushroom bacterium 30～60, Radix Actinidiae Chinensis 30～60, Fructificatio Amaurodermatis Rudae 10～15, Semen Cuscutae 15～25, Fructus Psoraleae 5～15, Fructus Ligustri Lucidi 15～25, Herba Ecliptae 15～25, Rhizoma Atractylodis Macrocephalae (parched) 15～25, Rhizoma Dioscoreae 15～25 compositions.Application publication number is CN101926429A(application number 201010239490.2) Chinese patent literature a kind of by name " can strengthen nutritional solution and the preparation method of chemotherapeutic period immunity " disclosed, this nutritional solution is to be the Carnis Haliotidis polysaccharide of 2%-20% and the mixed solution of fucoidan by solid content, according to Carnis Haliotidis polysaccharide 5-50mg/100ml, the proportioning of fucoidan 100-1000mg/100ml is mixed, and in mixed solution, add Pericarpium Citri Reticulatae to boil to make.Application publication number is CN102327390A(application number 201110314905.2) Chinese patent literature a kind of by name " a kind of preparation method of Chinese prescription and the pill thereof of preventing and treating chemotherapy toxic side effect " disclosed, it is made up of according to certain weight proportion Colla Corii Asini, Radix Ginseng, Cortex Cinnamomi, Rhizoma Chuanxiong, Radix Rehmanniae Preparata, Poria, the Rhizoma Atractylodis Macrocephalae, the Radix Astragali, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Semen Cuscutae, Fructus Lycii, Radix Cyathulae, Pericarpium Citri Reticulatae, Ganoderma, Herba Cistanches, Cornu Cervi Pantotrichum, Moschus, Stalactitum, Radix Morindae Officinalis, Radix Aconiti Lateralis Preparata, Stichopus japonicus, Radix Glycyrrhizae, Colla cornus cervi, yellow wine.
In a word, Chinese medicine is being obtained certain effect aspect the side reaction for the treatment of Radiotherapy chemotherapy, but also has some problems: the therapeutic effect of the immunity aspect to raising patient is desirable not enough clinically; Some formula medical materials are numerous, and medical material cost is higher, is not suitable for most people and takes, and therefore needs further perfect.
Summary of the invention
For the deficiencies in the prior art, one of object of the present invention is to provide that one is prepared simply, taking convenience, portable Chinese medicine composition, and the toxicity that Radiotherapy chemotherapy is caused has good therapeutic effect, can improve patient's immunologic function.
Another object of the present invention is just to provide the preparation method of above-mentioned Chinese medicine composition.
Technical scheme of the present invention is:
Improve the Chinese medicine composition of tumor patient Postoperative Immunity function, take off the primary raw material of stating weight proportion and be prepared from: Radix Codonopsis 8-16 part, Radix Cyathulae 3-12 part, Fructus Ligustri Lucidi 6-12 part, Poria cum Radix Pini 6-9 part, Thallus Laminariae (Thallus Eckloniae) 6-14 part, Radix Puerariae 20-35 part, Herba Artemisiae Anomalae 6-15 part, Rhizoma Chuanxiong 6-15 part, Poria 6-12 part, Herba Centellae 3-6 part, Fructus Psoraleae (salt is processed) 2-8 part, Fructus Toosendan 3-9 part, Pollen Pini 5-9 part.
Improve the Chinese medicine composition of tumor patient Postoperative Immunity function, preferred scheme is, takes off the primary raw material of stating weight proportion and is prepared from: Radix Codonopsis 10-14 part, Radix Cyathulae 5-9 part, Fructus Ligustri Lucidi 8-10 part, Poria cum Radix Pini 6-8 part, Thallus Laminariae (Thallus Eckloniae) 8-12 part, Radix Puerariae 25-30 part, Herba Artemisiae Anomalae 9-12 part, Rhizoma Chuanxiong 9-13 part, Poria 8-10 part, Herba Centellae 3-5 part, Fructus Psoraleae (salt is processed) 4-6 part, Fructus Toosendan 5-7 part, Pollen Pini 6-8 part.
Improve the Chinese medicine composition of tumor patient Postoperative Immunity function, the scheme being more preferably is, takes off the primary raw material of stating weight proportion and is prepared from: 12 parts of Radix Codonopsis, 7 parts of Radix Cyathulaes, 9 parts of Fructus Ligustri Lucidi, 7 parts of Poria cum Radix Pinis, 10 parts of Thallus Laminariae (Thallus Eckloniae)s, 28 parts of Radix Puerariaes, 10 parts of Herba Artemisiae Anomalaes, 11 parts of Rhizoma Chuanxiongs, 9 parts, Poria, 4 parts of Herba Centellaes, 5 parts of Fructus Psoraleaes (salt is processed), 6 parts of Fructus Toosendans, 7 parts of Pollen Pinis.
The present invention also provides above-mentioned Chinese medicine composition has been made to pharmaceutically acceptable powder, water preparation, unguentum, granule, tablet or capsule.
The preparation method of described powder is:
(1) Pollen Pini is pulverized, crossed 100-140 mesh sieve and (preferably, cross 110-130 mesh sieve; Be more preferably, cross 120 mesh sieves);
(2) Radix Codonopsis, Radix Cyathulae, Fructus Ligustri Lucidi, Poria cum Radix Pini, Thallus Laminariae (Thallus Eckloniae), Radix Puerariae, Herba Artemisiae Anomalae, Rhizoma Chuanxiong, Poria, Herba Centellae, Fructus Psoraleae (salt is processed) and Fructus Toosendan co-grinding are crossed to 65-125 mesh sieve and (preferably, crossed 80-110 mesh sieve; Be more preferably, cross 95 mesh sieves);
(3) step (1) and (2) gained are mixed.
The preparation method of described water preparation is:
(1) Pollen Pini is pulverized, crossed 100-140 mesh sieve and (preferably, cross 110-130 mesh sieve; Be more preferably, cross 120 mesh sieves);
(2) Radix Codonopsis, Radix Cyathulae, Fructus Ligustri Lucidi, Poria cum Radix Pini, Thallus Laminariae (Thallus Eckloniae), Radix Puerariae, Herba Artemisiae Anomalae, Rhizoma Chuanxiong, Poria, Herba Centellae, Fructus Psoraleae (salt is processed) and Fructus Toosendan are placed in marmite, adding water, (water consumption is 2-4 times (preferably, 2.5-3.5 times of crude drug gross weight; Be more preferably 3 times)) decoct 1.5-2.5 hour for the first time (preferred 1.8-2.2 hour 3 times; Be more preferably 2 hours), 0.5-1.2 hour for the second time (preferred, 0.7-1.0 hour; Be more preferably 0.8 hour), 0.5-1.2 hour for the third time (preferred, 0.7-1.0 hour; Be more preferably 0.8 hour), three gained filtrates are merged, leave standstill, filter;
(3) Pollen Pini after step (1) pulverizing is added to step (2) gained medicinal liquid, sterile packaged.
The preparation method of described unguentum is:
(1) Pollen Pini is pulverized, crossed 100-140 mesh sieve and (preferably, cross 110-130 mesh sieve; Be more preferably, cross 120 mesh sieves);
(2) Radix Codonopsis, Radix Cyathulae, Fructus Ligustri Lucidi, Poria cum Radix Pini, Thallus Laminariae (Thallus Eckloniae), Radix Puerariae, Herba Artemisiae Anomalae, Rhizoma Chuanxiong, Poria, Herba Centellae, Fructus Psoraleae (salt is processed) and Fructus Toosendan are placed in marmite, adding water, (water consumption is 2-4 times (preferably, 2.5-3.5 times of crude drug gross weight; Be more preferably 3 times)) decoct 1.5-2.5 hour for the first time (preferred 1.8-2.2 hour 3 times; Be more preferably 2 hours), 0.5-1.2 hour for the second time (preferred, 0.7-1.0 hour; Be more preferably 0.8 hour), 0.5-1.2 hour for the third time (preferred, 0.7-1.0 hour; Be more preferably 0.8 hour), three gained filtrates are merged, leave standstill, filter;
(3) step (2) gained filtrate being concentrated into relative density is 1.05-1.50(50 ℃) clear paste, be cooled to room temperature;
(4) Pollen Pini after step (1) pulverizing is added to step (3) gained clear paste, sterile packaged.
The preparation method of described granule is:
(1) Pollen Pini is pulverized, crossed 100-140 mesh sieve and (preferably, cross 110-130 mesh sieve; Be more preferably, cross 120 mesh sieves);
(2) Radix Codonopsis, Radix Cyathulae, Fructus Ligustri Lucidi, Poria cum Radix Pini, Thallus Laminariae (Thallus Eckloniae), Radix Puerariae, Herba Artemisiae Anomalae, Rhizoma Chuanxiong, Poria, Herba Centellae, Fructus Psoraleae (salt is processed) and Fructus Toosendan are placed in marmite, adding water, (water consumption is 2-4 times (preferably, 2.5-3.5 times of crude drug gross weight; Be more preferably 3 times)) decoct 1.5-2.5 hour for the first time (preferred 1.8-2.2 hour 3 times; Be more preferably 2 hours), 0.5-1.2 hour for the second time (preferred, 0.7-1.0 hour; Be more preferably 0.8 hour), 0.5-1.2 hour for the third time (preferred, 0.7-1.0 hour; Be more preferably 0.8 hour), three gained filtrates are merged, leave standstill, filter;
(3) step (2) gained filtrate being concentrated into relative density is 1.05-1.50(50 ℃) clear paste, be cooled to room temperature;
(4) qinghuo reagent 0.5-1.2 part (preferably, 0.7-1.0 part; Be more preferably 0.8 part), add the Pollen Pini after step (1) is pulverized, mix, with sucrose 4-7 part (preferably, 5-7 part; Be more preferably 6 parts) and appropriate amount of ethanol, granulation, dry.
The preparation method of described tablet is: by claim 5 gained powder according to 0.4-0.8g/ sheet (preferred, 0.5-0.7g/ sheet; Be more preferably 0.6g/ sheet) measure, be pressed into the lamellar dosage form of circle or other shapes according to the preparation for processing of tablet.
The preparation method of described capsule is: by claim 5 gained medicament powder according to 0.6-1.0g/ grain (preferred, 0.7-0.9g/ grain; Be more preferably 0.8g/ grain) metering, be processed into capsule shape dosage form according to the preparation for processing of capsule.
The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:
Radix Codonopsis: nature and flavor: property is sweet is flat.Gui Jing: return spleen, lung meridian.Effect: strengthening spleen, tonifying kidney, supplementing QI for promoting the production of body fluid.Cure mainly: weakness of the spleen and stomach, anorexia and loose stool, limbs fatigue, the deficiency of the lung is breathed with cough, the spontaneous perspiration of breathing hard, all diseases of deficiency of both QI and blood.
Radix Cyathulae: nature and flavor: sweet in the mouth, bitter in the mouth are flat.Gui Jing: return liver, kidney channel.Effect: promoting blood circulation to remove blood stasis, expelling wind and removing dampness.Cure mainly: blood stasis amenorrhea, difficult labour, retention of placenta, puerperal abdominalgia with blood stasis, pyretic stranguria, stranguria caused by urinary stone, dysmenorrhea, rheumatism lumbocrural pain, traumatic injury.
Fructus Ligustri Lucidi: nature and flavor: taste sweet, bitter, cold.Gui Jing: return liver, kidney channel.Effect: liver and kidney tonifying, clearind deficient heat you, improving eyesight.Cure mainly: Light-headedness, soreness of the waist and knees, seminal emission, tinnitus, early whitening of beard and hair, osteopyrexia and fever, poor vision.
Poria cum Radix Pini: nature and flavor: sweet in the mouth is light, flat.Gui Jing: GUIXIN, lung meridian.Effect: mind calming, calm the nerves, diuretic.Cure mainly: the palpitation with fear of having a guilty conscience, forgetful, insomnia, infantile convulsion, dysuria.
Thallus Laminariae (Thallus Eckloniae): nature and flavor: salty in the mouth, cold.Gui Jing: return liver, stomach, kidney channel.Effect: softening and eliminating sputum, inducing diuresis to remove edema.Cure mainly: goiter, scrofula, swelling of the scrotum, the cancer of the esophagus, beriberi edema.
Radix Puerariae: nature and flavor: sweet in the mouth, pungent is flat.Gui Jing: return spleen, stomach warp.Effect: yang invigorating expelling pathogenic factors from muscles, rash antidiarrheal, relieving restlessness is temperature only.Cure mainly: typhoid fever, warm headache stiffness of the nape, dysphoria with smothery sensation is quenched one's thirst, has loose bowels, dysentery, skin eruption is not saturating, hypertension, angina pectoris, deafness.
Herba Artemisiae Anomalae: nature and flavor: bitter in the mouth, temperature.Gui Jing: GUIXIN, lung meridian.Effect: removing blood stasis stimulates the menstrual flow, healing up sore and subduing swelling.Cure mainly: amenorrhea lump in the abdomen, chest and abdomen swelling and pain, puerperal blood stasis, traumatic injury, incised wound is hemorrhage, Yong Du burning swelling.
Rhizoma Chuanxiong: nature and flavor: acrid in the mouth, temperature.Gui Jing: return liver, gallbladder pericardium channel.Effect: blood circulation promoting and blood stasis dispelling, activating QI to alleviate the depression, wind-expelling pain-stopping.Cure mainly: menoxenia, amenorrhea dysmenorrhea, the stagnant stomachache of the stasis of blood in puerperal, lump in the abdomen lump, pain in chest and hypochondrium, has a headache dizzy, anemofrigid-damp arthralgia, traumatic injury, ulcer sores.
Poria: nature and flavor: sweet in the mouth, light is flat.Gui Jing: GUIXIN, lung, spleen, kidney channel.Effect: promoting diuresis to eliminate damp pathogen, spleen invigorating mind calming.Cure mainly: for edema oliguria, phlegm retention vertigo and palpitation, insufficiency of the spleen lack of appetite, have loose bowels in loose stool, irritability, palpitation with fear insomnia.
Herba Centellae: nature and flavor: taste bitter, acrid, cold.Gui Jing: return liver,spleen,kidney warp.Effect: heat-clearing and toxic substances removing, inducing diuresis and reducing edema.Be Asians's long-lived medicine, can refresh oneself by beneficial brain.Research shows to have nourishing, antiinflammatory, healing of wound, diuresis relieving constipation and calm effect.Also effective in cure to leprosy, ulcer, blood purification and immunity are had to activation, because it can stimulate the replacement of deep skin cell.It is neural nourishing agent, can improve memory, alleviates mental fatigue; Also can blood pressure lowering, treatment hepatopathy etc.
Fructus Psoraleae (salt is processed): nature and flavor: acrid in the mouth, hardship, temperature.Gui Jing: return kidney, spleen channel.Effect: reinforcing the kidney and supporting YANG, helping inspiration to relieve asthma, warming spleen and stopping diarrha.Cure mainly: main insufficiency of kidney-YANG, below element deficiency and cold, chills and pain of the waist and kness, impotence and seminal emission, frequent micturition, the enuresis, failure of the kidney in receiving QI, dyspnea due to deficiency is more than, asthenia of both the spleen and kidney, stool chronic diarrhea, outward for vitiligo, alopecia areata, psoriasis.Fructus Toosendan: nature and flavor: bitter in the mouth, cold; Slightly poisonous.Gui Jing: return liver, small intestinal, urinary bladder channel.Effect: soothing the liver promoting the circulation of QI to relieve pain, anthelmintic.Cure mainly: for the breast side of body, abdominal distention, colic, abdominal pain due to worm stagnation.
Pollen Pini: nature and flavor: sweet in the mouth, temperature.Gui Jing: return liver, spleen channel.Effect: the QI invigorating of dispeling the wind, removing dampness, hemostasis.Cure mainly: head revolves dizzy, and middle void has a stomach-ache, chronic dysentery, all skin ulcers are wet rotten, wound hemorrhage.
Chinese medicine composition prescription science provided by the invention, the preparation method of various dosage forms is simple, makes products obtained therefrom taking convenience, is easy to carry.In addition, excellent results of the present invention also shows:
1. this prescription meets the body and mind feature of Chinese medicine principle and tumour patient completely, can effectively improve tumor patient Postoperative Immunity function.
2. selected materials is all Chinese medicine material, without any side effects.
3. medicine source is easy to get, and medical material is with low cost, energy ameliorate tumor patient's financial burden.
The specific embodiment
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited to this.
embodiment 1improve the Chinese medicine composition of tumor patient Postoperative Immunity function, take off the primary raw material of stating weight proportion and be prepared from (getting 10g for every part): 12 parts of Radix Codonopsis, 7 parts of Radix Cyathulaes, 9 parts of Fructus Ligustri Lucidi, 7 parts of Poria cum Radix Pinis, 10 parts of Thallus Laminariae (Thallus Eckloniae)s, 28 parts of Radix Puerariaes, 10 parts of Herba Artemisiae Anomalaes, 11 parts of Rhizoma Chuanxiongs, 9 parts, Poria, 4 parts of Herba Centellaes, 5 parts of Fructus Psoraleaes (salt is processed), 6 parts of Fructus Toosendans, 7 parts of Pollen Pinis.
The preparation method of above-mentioned Chinese medicine composition medicinal powder is:
(1) Pollen Pini is pulverized, crossed 120 mesh sieves;
(2) Radix Codonopsis, Radix Cyathulae, Fructus Ligustri Lucidi, Poria cum Radix Pini, Thallus Laminariae (Thallus Eckloniae), Radix Puerariae, Herba Artemisiae Anomalae, Rhizoma Chuanxiong, Poria, Herba Centellae, Fructus Psoraleae (salt is processed) and Fructus Toosendan co-grinding are crossed to 95 mesh sieves;
(3) step (1) and (2) gained are mixed.
Powder instructions of taking of the present invention: divide 10g/ bag by powder, adopt every day 2-3 time, each one bag, use warm boiled water, 7 days courses for the treatment of.
model case onebeam XX, the age: 46 years old, sex: man.Suffer from the two cervical lymph nodes of rhinitis scale cancer in June, 2006 and shift, regularly treat by Radiotherapy chemotherapy.Radiotherapy chemotherapy causes some toxicities: immunologic function degression, nausea and vomiting, inappetence, dry mouth and tougue, malaise etc.Take the present embodiment gained Chinese medicine composition medicinal powder, adopt every day 3 times, each one bag, with warm boiled water, 7 days courses for the treatment of.Take 10 days, patient's dry mouth and tougue symptom alleviates, and appetite is cumulative; Take 1 month, patient's malaise symptoms fades away, and immunologic function improves; Continue to take 2 months, patient's self-induction is without malaise symptoms.
embodiment 2improve the Chinese medicine composition of tumor patient Postoperative Immunity function, take off the primary raw material of stating weight proportion and be prepared from (getting 20g for every part): 12 parts of Radix Codonopsis, 7 parts of Radix Cyathulaes, 9 parts of Fructus Ligustri Lucidi, 7 parts of Poria cum Radix Pinis, 10 parts of Thallus Laminariae (Thallus Eckloniae)s, 28 parts of Radix Puerariaes, 10 parts of Herba Artemisiae Anomalaes, 11 parts of Rhizoma Chuanxiongs, 9 parts, Poria, 4 parts of Herba Centellaes, 5 parts of Fructus Psoraleaes (salt is processed), 6 parts of Fructus Toosendans, 7 parts of Pollen Pinis.
The preparation method of above-mentioned Chinese medicine composition unguentum is:
(1) Pollen Pini is pulverized, crossed 120 mesh sieves;
(2) Radix Codonopsis, Radix Cyathulae, Fructus Ligustri Lucidi, Poria cum Radix Pini, Thallus Laminariae (Thallus Eckloniae), Radix Puerariae, Herba Artemisiae Anomalae, Rhizoma Chuanxiong, Poria, Herba Centellae, Fructus Psoraleae (salt is processed) and Fructus Toosendan are placed in marmite, (water consumption is 3 times of crude drug gross weight) decoction 3 times adds water, 2 hours for the first time, 0.8 hour for the second time, 0.8 hour for the third time, three gained filtrates are merged, leave standstill, filter;
(3) step (2) gained filtrate being concentrated into relative density is 1.05-1.50(50 ℃) clear paste, be cooled to room temperature;
(4) Pollen Pini after step (1) pulverizing is added to step (3) gained clear paste, sterile packaged.
Unguentum instructions of taking of the present invention: unguentum adopts every day 2 times, each 6-12g, takes 7 days courses for the treatment of according to the ratio bath of 1:10.
model case twopan XX, the age: 58 years old, sex: man.The malaise symptoms such as patient, because suffering from the low differentiated squamous-cell carcinomas of nasopharynx part, starts chemotherapy in March, 2008, occurs heating after chemotherapy, and xerostomia is weak weak, and appetite is low, immunity degradation, now become thin abnormal, take anti-chemotherapy side effect medicine, all ineffective.Take the present embodiment gained Chinese medicine composition unguentum, adopt every day 2 times, each 10g, takes 7 days courses for the treatment of according to the ratio bath of 1:10.Take 14 days, patient's malaise symptoms alleviates; Take 2 months, patient's immunity strengthens, and muscle power strengthens, and malaise symptoms fades away; Continue to take the recovery from illness of patient's self-induction 2 months.
embodiment 3improve the Chinese medicine composition of tumor patient Postoperative Immunity function, take off the primary raw material of stating weight proportion and be prepared from (every part of 30g): 12 parts of Radix Codonopsis, 7 parts of Radix Cyathulaes, 9 parts of Fructus Ligustri Lucidi, 7 parts of Poria cum Radix Pinis, 10 parts of Thallus Laminariae (Thallus Eckloniae)s, 28 parts of Radix Puerariaes, 10 parts of Herba Artemisiae Anomalaes, 11 parts of Rhizoma Chuanxiongs, 9 parts, Poria, 4 parts of Herba Centellaes, 5 parts of Fructus Psoraleaes (salt is processed), 6 parts of Fructus Toosendans, 7 parts of Pollen Pinis.
The preparation method of above-mentioned Chinese medicinal composition granules is:
(1) Pollen Pini is pulverized, crossed 120 mesh sieves;
(2) Radix Codonopsis, Radix Cyathulae, Fructus Ligustri Lucidi, Poria cum Radix Pini, Thallus Laminariae (Thallus Eckloniae), Radix Puerariae, Herba Artemisiae Anomalae, Rhizoma Chuanxiong, Poria, Herba Centellae, Fructus Psoraleae (salt is processed) and Fructus Toosendan are placed in marmite, (water consumption is 3 times of crude drug gross weight) decoction 3 times adds water, 2 hours for the first time, 0.8 hour for the second time, 0.8 hour for the third time, three gained filtrates are merged, leave standstill, filter;
(3) step (2) gained filtrate being concentrated into relative density is 1.05-1.50(50 ℃) clear paste, be cooled to room temperature;
(4) 0.8 part of qinghuo reagent, adds the Pollen Pini after step (1) is pulverized, mixes, and with 6 parts of sucrose and appropriate amount of ethanol, granulation, dry.
Granule instructions of taking of the present invention: divide 8g/ bag by granule, every day 2-3 time, each one bag, with warm boiled water, 7 days courses for the treatment of.
model case threewu XX, the age: 52 years old, sex: female.Patient's in January, 2007 left newborn wettability duct carcinoma radical correction, axillary lymph is carried down and is moved, and postoperatively carries out two cycles of chemotherapy and does again radiotherapy.Occur after Radiotherapy chemotherapy pale complexion, dizzy weak, become thin, immunity degradation, nausea and vomiting, without malaise symptoms such as appetite.Take the present embodiment gained Chinese medicinal composition granules, adopt every day 3 times, each 1 one bags, with warm boiled water, 7 days courses for the treatment of.Take 21 days, patient's appetite strengthens, and malaise symptoms improves gradually; Take 2 months, patient's immunity improves, and the mental status is clearly better, and malaise symptoms fades away; Continue to take 2 months, malaise symptoms disappears completely.
embodiment 4improve the Chinese medicine composition of tumor patient Postoperative Immunity function, take off the primary raw material of stating weight proportion and be prepared from (every part of 40g): 12 parts of Radix Codonopsis, 7 parts of Radix Cyathulaes, 9 parts of Fructus Ligustri Lucidi, 7 parts of Poria cum Radix Pinis, 10 parts of Thallus Laminariae (Thallus Eckloniae)s, 28 parts of Radix Puerariaes, 10 parts of Herba Artemisiae Anomalaes, 11 parts of Rhizoma Chuanxiongs, 9 parts, Poria, 4 parts of Herba Centellaes, 5 parts of Fructus Psoraleaes (salt is processed), 6 parts of Fructus Toosendans, 7 parts of Pollen Pinis.
The preparation method of above-mentioned Chinese medicine composition tablet is:
(1) Pollen Pini is pulverized, crossed 120 mesh sieves;
(2) Radix Codonopsis, Radix Cyathulae, Fructus Ligustri Lucidi, Poria cum Radix Pini, Thallus Laminariae (Thallus Eckloniae), Radix Puerariae, Herba Artemisiae Anomalae, Rhizoma Chuanxiong, Poria, Herba Centellae, Fructus Psoraleae (salt is processed) and Fructus Toosendan co-grinding are crossed to 95 mesh sieves;
(3) step (1) and (2) gained are mixed to obtain to powder;
(4) step (3) gained powder is measured according to 0.6g/ sheet, be pressed into the lamellar dosage form of circle or other shapes according to the preparation for processing of tablet.
Tablets method of the present invention: tablet adopts every day 3 times, each 6-10 sheet, with warm boiled water, 7 days courses for the treatment of.
model case fourwu XX, the age: 55 years old, sex: female.Find right tonsil malignant lymphoma in April, 2009, through chemotherapy, radiotherapy, swollen thing disappears, grow again multiple swollen things as large in Ovum Columba livia-egg in July, 2010 in right groin, right neck, left oxter, row chemotherapy is alleviated to some extent again, but Radiotherapy chemotherapy causes the symptoms such as health is tired, drowsiness, night sweat, lassitude, weakness of the spleen and stomach.Take the present embodiment gained Chinese medicine composition tablet, inferior to every day 3 times, each 8, with warm boiled water, 7 days courses for the treatment of.Take 15 days, night sweat, drowsiness symptom alleviate, and malaise symptoms is alleviated; Take 1 month, patient's appetite strengthens, and the mental status is improved, and malaise symptoms fades away; Continue to take 2 months, patient's malaise symptoms disappears completely.
embodiment 5improve the Chinese medicine composition of tumor patient Postoperative Immunity function, take off the primary raw material of stating weight proportion and be prepared from (every part of 50g): 12 parts of Radix Codonopsis, 7 parts of Radix Cyathulaes, 9 parts of Fructus Ligustri Lucidi, 7 parts of Poria cum Radix Pinis, 10 parts of Thallus Laminariae (Thallus Eckloniae)s, 28 parts of Radix Puerariaes, 10 parts of Herba Artemisiae Anomalaes, 11 parts of Rhizoma Chuanxiongs, 9 parts, Poria, 4 parts of Herba Centellaes, 5 parts of Fructus Psoraleaes (salt is processed), 6 parts of Fructus Toosendans, 7 parts of Pollen Pinis.
The preparation method of above-mentioned Chinese medicinal composition capsules agent is:
(1) Pollen Pini is pulverized, crossed 120 mesh sieves;
(2) Radix Codonopsis, Radix Cyathulae, Fructus Ligustri Lucidi, Poria cum Radix Pini, Thallus Laminariae (Thallus Eckloniae), Radix Puerariae, Herba Artemisiae Anomalae, Rhizoma Chuanxiong, Poria, Herba Centellae, Fructus Psoraleae (salt is processed) and Fructus Toosendan co-grinding are crossed to 95 mesh sieves;
(3) step (1) and (2) gained are mixed to obtain to powder;
(4) step (3) gained powder is measured according to 0.8g/ grain, be processed into capsule shape dosage form according to the preparation for processing of capsule.
Capsule instructions of taking of the present invention: capsule adopts every day 3 times, each 5-8 grain, with warm boiled water, 7 days courses for the treatment of.
model case fiveliu XX, the age: 63 years old, sex: man.Within 2008, suffer from malignant tumor of esophagus, accept chemotherapy in hospital, occur the symptoms such as acroanesthesia, nausea and vomiting, xerosis cutis, inappetence, health be tired after chemotherapy, ate the medicine of many anti-chemotherapy side effects, all without positive effect.Take the agent of this enforcement Chinese medicinal composition capsules, adopt every day 3 times, each 6, with warm boiled water, 7 days courses for the treatment of.Take 7 days, patient's appetite strengthens to some extent, and nausea and vomiting symptom alleviates; Take 1 month, malaise symptoms is clearly better, and muscle power strengthens; Continue to take 2 months, immunity strengthens, and patient's readme malaise symptoms disappears.
embodiment 6improve the Chinese medicine composition of tumor patient Postoperative Immunity function, take off the primary raw material of stating weight proportion and be prepared from (every part of 60g): 12 parts of Radix Codonopsis, 7 parts of Radix Cyathulaes, 9 parts of Fructus Ligustri Lucidi, 7 parts of Poria cum Radix Pinis, 10 parts of Thallus Laminariae (Thallus Eckloniae)s, 28 parts of Radix Puerariaes, 10 parts of Herba Artemisiae Anomalaes, 11 parts of Rhizoma Chuanxiongs, 9 parts, Poria, 4 parts of Herba Centellaes, 5 parts of Fructus Psoraleaes (salt is processed), 6 parts of Fructus Toosendans, 7 parts of Pollen Pinis.
The preparation method of above-mentioned Chinese medicine composition water preparation is:
(1) Pollen Pini is pulverized, crossed 120 mesh sieves;
(2) Radix Codonopsis, Radix Cyathulae, Fructus Ligustri Lucidi, Poria cum Radix Pini, Thallus Laminariae (Thallus Eckloniae), Radix Puerariae, Herba Artemisiae Anomalae, Rhizoma Chuanxiong, Poria, Herba Centellae, Fructus Psoraleae (salt is processed) and Fructus Toosendan are placed in marmite, (water consumption is 3 times of crude drug gross weight) decoction 3 times adds water, 2 hours for the first time, 0.8 hour for the second time, 0.8 hour for the third time, three gained filtrates are merged, leave standstill, filter;
(3) Pollen Pini after step (1) pulverizing is added to step (2) gained medicinal liquid, sterile packaged.
Water preparation instructions of taking of the present invention: water preparation adopts every day 2 times (warm), each 300-500ml, 7 days courses for the treatment of.
test example 1the clinical practice of embodiment 6 gained Chinese medicine composition water preparations: in May, 2009-2012 year April, screen 100 routine patients in 6 hospitals, wherein women's 43 examples, male's 57 examples.Test 2 weeks before, carries out Continuous Observation to this crowd, records symptom and variation, be divided at random two groups, experimental group and matched group, experimental group is taken embodiment 6 products obtained therefroms, and matched group is taken other medicine (the conventional medicine such as safe peace oral liquid, holy liquid oral liquid).Using method is: take every day twice (warm), each 300m1-500m1(adjusts to some extent depending on concrete condition), 7 days courses for the treatment of.Curative effect situation criterion: cure: take a course for the treatment of of this product, malaise symptoms disappears, energy and muscle power obviously strengthen; Effective: take a course for the treatment of of this product, malaise symptoms alleviates or part disappears, and energy and muscle power strengthen; Invalid: take a course for the treatment of of this product, malaise symptoms is unchanged.Result is as shown in table 1.
Table 1: take embodiment 6 products obtained therefrom therapeutic effect checkings
| Experimental group | Matched group | |
| Number of cases | 50 | 50 |
| Male's number of cases | 30 | 27 |
| Women's number of cases | 20 | 23 |
| Clinical cure number of cases | 35 | 11 |
| Effectively number of cases | 14 | 24 |
| Invalid number of cases | 1 | 15 |
| Total effective rate | 98% | 72% |
Therapeutic effect: cure 35 examples (70%), effective 14 examples (28%), invalid 1 example (2%), total effective rate 98%.Successful is better than matched group.
During taking, self-induction symptom and physical change of spirit thereof are as shown in table 2.
Table 2:
The present invention selects Radix Codonopsis, Radix Cyathulae, Fructus Ligustri Lucidi, Poria cum Radix Pini, Thallus Laminariae (Thallus Eckloniae) etc. to carry out compatibility, makes medicine produce synergism, and the side reaction of the more effective treatment Radiotherapy chemotherapy of energy, improves patient's immunity.Take 20 days, more than 53% patient's immunity strengthens, malaise symptoms takes a turn for the better to some extent; Take 40 days, more than 74% patient feels to take a turn for the better to some extent, and malaise symptoms improves or disappears, and spirit, muscle power strengthen; Take 60 days, more than 95% feeling takes a turn for the better to some extent, and immunity obviously strengthens, and malaise symptoms improves or disappears, and spirit, muscle power strengthen, the recovery from illness of some patients were self-induction.In experimental group, take more than 30 days, effective percentage can reach 95%, and matched group is only 75%.
It should be pointed out that the specific embodiment is the more representational example of the present invention, obvious technical scheme of the present invention is not limited to above-described embodiment, can also have a lot of distortion.Those of ordinary skill in the art, with the present invention clearly disclosed or according to undoubted the obtaining of the written description of file, all should think the claimed scope of this patent.
Claims (10)
1. the Chinese medicine composition that improves tumor patient Postoperative Immunity function, is characterized in that, takes off the primary raw material of stating weight proportion and is prepared from: Radix Codonopsis 8-16 part, Radix Cyathulae 3-12 part, Fructus Ligustri Lucidi 6-12 part, Poria cum Radix Pini 6-9 part, Thallus Laminariae (Thallus Eckloniae) 6-14 part, Radix Puerariae 20-35 part, Herba Artemisiae Anomalae 6-15 part, Rhizoma Chuanxiong 6-15 part, Poria 6-12 part, Herba Centellae 3-6 part, Fructus Psoraleae (salt is processed) 2-8 part, Fructus Toosendan 3-9 part, Pollen Pini 5-9 part.
2. Chinese medicine composition according to claim 1, is characterized in that, takes off the primary raw material of stating weight proportion and is prepared from: Radix Codonopsis 10-14 part, Radix Cyathulae 5-9 part, Fructus Ligustri Lucidi 8-10 part, Poria cum Radix Pini 6-8 part, Thallus Laminariae (Thallus Eckloniae) 8-12 part, Radix Puerariae 25-30 part, Herba Artemisiae Anomalae 9-12 part, Rhizoma Chuanxiong 9-13 part, Poria 8-10 part, Herba Centellae 3-5 part, Fructus Psoraleae (salt is processed) 4-6 part, Fructus Toosendan 5-7 part, Pollen Pini 6-8 part.
3. Chinese medicine composition according to claim 1, is characterized in that, takes off the primary raw material of stating weight proportion and is prepared from: 12 parts of Radix Codonopsis, 7 parts of Radix Cyathulaes, 9 parts of Fructus Ligustri Lucidi, 7 parts of Poria cum Radix Pinis, 10 parts of Thallus Laminariae (Thallus Eckloniae)s, 28 parts of Radix Puerariaes, 10 parts of Herba Artemisiae Anomalaes, 11 parts of Rhizoma Chuanxiongs, 9 parts, Poria, 4 parts of Herba Centellaes, 5 parts of Fructus Psoraleaes (salt is processed), 6 parts of Fructus Toosendans, 7 parts of Pollen Pinis.
4. according to the arbitrary described Chinese medicine composition of claim 1-3, it is characterized in that, this Chinese medicine composition is made to pharmaceutically acceptable powder, water preparation, unguentum, granule, tablet or capsule.
5. Chinese medicine composition according to claim 4, is characterized in that, the preparation method of described powder is:
(1) Pollen Pini is pulverized, crossed 100-140 mesh sieve and (preferably, cross 110-130 mesh sieve; Be more preferably, cross 120 mesh sieves);
(2) Radix Codonopsis, Radix Cyathulae, Fructus Ligustri Lucidi, Poria cum Radix Pini, Thallus Laminariae (Thallus Eckloniae), Radix Puerariae, Herba Artemisiae Anomalae, Rhizoma Chuanxiong, Poria, Herba Centellae, Fructus Psoraleae (salt is processed) and Fructus Toosendan co-grinding are crossed to 65-125 mesh sieve and (preferably, crossed 80-110 mesh sieve; Be more preferably, cross 95 mesh sieves);
(3) step (1) and (2) gained are mixed.
6. Chinese medicine composition according to claim 4, is characterized in that, the preparation method of described water preparation is:
(1) Pollen Pini is pulverized, crossed 100-140 mesh sieve and (preferably, cross 110-130 mesh sieve; Be more preferably, cross 120 mesh sieves);
(2) Radix Codonopsis, Radix Cyathulae, Fructus Ligustri Lucidi, Poria cum Radix Pini, Thallus Laminariae (Thallus Eckloniae), Radix Puerariae, Herba Artemisiae Anomalae, Rhizoma Chuanxiong, Poria, Herba Centellae, Fructus Psoraleae (salt is processed) and Fructus Toosendan are placed in marmite, adding water, (water consumption is 2-4 times (preferably, 2.5-3.5 times of crude drug gross weight; Be more preferably 3 times)) decoct 1.5-2.5 hour for the first time (preferred 1.8-2.2 hour 3 times; Be more preferably 2 hours), 0.5-1.2 hour for the second time (preferred, 0.7-1.0 hour; Be more preferably 0.8 hour), 0.5-1.2 hour for the third time (preferred, 0.7-1.0 hour; Be more preferably 0.8 hour), three gained filtrates are merged, leave standstill, filter;
(3) Pollen Pini after step (1) pulverizing is added to step (2) gained medicinal liquid, sterile packaged.
7. Chinese medicine composition according to claim 4, is characterized in that, the preparation method of described unguentum is:
(1) Pollen Pini is pulverized, crossed 100-140 mesh sieve and (preferably, cross 110-130 mesh sieve; Be more preferably, cross 120 mesh sieves);
(2) Radix Codonopsis, Radix Cyathulae, Fructus Ligustri Lucidi, Poria cum Radix Pini, Thallus Laminariae (Thallus Eckloniae), Radix Puerariae, Herba Artemisiae Anomalae, Rhizoma Chuanxiong, Poria, Herba Centellae, Fructus Psoraleae (salt is processed) and Fructus Toosendan are placed in marmite, adding water, (water consumption is 2-4 times (preferably, 2.5-3.5 times of crude drug gross weight; Be more preferably 3 times)) decoct 1.5-2.5 hour for the first time (preferred 1.8-2.2 hour 3 times; Be more preferably 2 hours), 0.5-1.2 hour for the second time (preferred, 0.7-1.0 hour; Be more preferably 0.8 hour), 0.5-1.2 hour for the third time (preferred, 0.7-1.0 hour; Be more preferably 0.8 hour), three gained filtrates are merged, leave standstill, filter;
(3) step (2) gained filtrate being concentrated into relative density is 1.05-1.50(50 ℃) clear paste, be cooled to room temperature;
(4) Pollen Pini after step (1) pulverizing is added to step (3) gained clear paste, sterile packaged.
8. Chinese medicine composition according to claim 4, is characterized in that, the preparation method of described granule is:
(1) Pollen Pini is pulverized, crossed 100-140 mesh sieve and (preferably, cross 110-130 mesh sieve; Be more preferably, cross 120 mesh sieves);
(2) Radix Codonopsis, Radix Cyathulae, Fructus Ligustri Lucidi, Poria cum Radix Pini, Thallus Laminariae (Thallus Eckloniae), Radix Puerariae, Herba Artemisiae Anomalae, Rhizoma Chuanxiong, Poria, Herba Centellae, Fructus Psoraleae (salt is processed) and Fructus Toosendan are placed in marmite, adding water, (water consumption is 2-4 times (preferably, 2.5-3.5 times of crude drug gross weight; Be more preferably 3 times)) decoct 1.5-2.5 hour for the first time (preferred 1.8-2.2 hour 3 times; Be more preferably 2 hours), 0.5-1.2 hour for the second time (preferred, 0.7-1.0 hour; Be more preferably 0.8 hour), 0.5-1.2 hour for the third time (preferred, 0.7-1.0 hour; Be more preferably 0.8 hour), three gained filtrates are merged, leave standstill, filter;
(3) step (2) gained filtrate being concentrated into relative density is 1.05-1.50(50 ℃) clear paste, be cooled to room temperature;
(4) qinghuo reagent 0.5-1.2 part (preferably, 0.7-1.0 part; Be more preferably 0.8 part), add the Pollen Pini after step (1) is pulverized, mix, with sucrose 4-7 part (preferably, 5-7 part; Be more preferably 6 parts) and appropriate amount of ethanol, granulation, dry.
9. Chinese medicine composition according to claim 4, is characterized in that, the preparation method of described tablet is: by claim 5 gained powder according to 0.4-0.8g/ sheet (preferred, 0.5-0.7g/ sheet; Be more preferably 0.6g/ sheet) measure, be pressed into the lamellar dosage form of circle or other shapes according to the preparation for processing of tablet.
10. Chinese medicine composition according to claim 4, is characterized in that, the preparation method of described capsule is: by claim 5 gained powder according to 0.6-1.0g/ grain (preferred, 0.7-0.9g/ grain; Be more preferably 0.8g/ grain) metering, be processed into capsule shape dosage form according to the preparation for processing of capsule.
Priority Applications (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410144866.XA CN103908495B (en) | 2014-04-12 | 2014-04-12 | Improve Chinese medicine composition and the method for making of tumor patient Postoperative Immunity function |
| CN201510209545.8A CN104815008A (en) | 2014-04-12 | 2014-04-12 | Traditional Chinese medicine powder for improving postoperative immune functions of tumor patients |
| CN201510209544.3A CN104771449A (en) | 2014-04-12 | 2014-04-12 | Traditional Chinese medicine ointment capable of improving post-operation immunity of cancer patient |
| CN201510209504.9A CN104784259A (en) | 2014-04-12 | 2014-04-12 | Capsules for improving postoperative immunologic function of tumor patient |
| CN201510209505.3A CN104784260A (en) | 2014-04-12 | 2014-04-12 | Traditional Chinese medicine tablets for improving postoperative immunologic function of tumor patient and preparation method |
| CN201510209341.4A CN104771448A (en) | 2014-04-12 | 2014-04-12 | Method for preparing traditional Chinese medicine drug granule improving postoperative immune function of tumor patient |
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| CN201510209504.9A Division CN104784259A (en) | 2014-04-12 | 2014-04-12 | Capsules for improving postoperative immunologic function of tumor patient |
| CN201510209545.8A Division CN104815008A (en) | 2014-04-12 | 2014-04-12 | Traditional Chinese medicine powder for improving postoperative immune functions of tumor patients |
| CN201510209341.4A Division CN104771448A (en) | 2014-04-12 | 2014-04-12 | Method for preparing traditional Chinese medicine drug granule improving postoperative immune function of tumor patient |
| CN201510209505.3A Division CN104784260A (en) | 2014-04-12 | 2014-04-12 | Traditional Chinese medicine tablets for improving postoperative immunologic function of tumor patient and preparation method |
| CN201510209544.3A Division CN104771449A (en) | 2014-04-12 | 2014-04-12 | Traditional Chinese medicine ointment capable of improving post-operation immunity of cancer patient |
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| CN201410144866.XA Expired - Fee Related CN103908495B (en) | 2014-04-12 | 2014-04-12 | Improve Chinese medicine composition and the method for making of tumor patient Postoperative Immunity function |
| CN201510209341.4A Withdrawn CN104771448A (en) | 2014-04-12 | 2014-04-12 | Method for preparing traditional Chinese medicine drug granule improving postoperative immune function of tumor patient |
| CN201510209504.9A Withdrawn CN104784259A (en) | 2014-04-12 | 2014-04-12 | Capsules for improving postoperative immunologic function of tumor patient |
| CN201510209544.3A Withdrawn CN104771449A (en) | 2014-04-12 | 2014-04-12 | Traditional Chinese medicine ointment capable of improving post-operation immunity of cancer patient |
| CN201510209505.3A Withdrawn CN104784260A (en) | 2014-04-12 | 2014-04-12 | Traditional Chinese medicine tablets for improving postoperative immunologic function of tumor patient and preparation method |
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| CN201510209544.3A Withdrawn CN104771449A (en) | 2014-04-12 | 2014-04-12 | Traditional Chinese medicine ointment capable of improving post-operation immunity of cancer patient |
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| CN104489516A (en) * | 2014-12-03 | 2015-04-08 | 姜秀清 | Health-preserving porridge capable of improving postoperative immune function of cancer paint and preparation method for health-preserving porridge |
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| CN1840036A (en) * | 2005-03-29 | 2006-10-04 | 上海围城自由基生物工程研究所 | Chinese medicinal composite preparation capable of inhibiting growth of tumor cell |
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- 2014-04-12 CN CN201410144866.XA patent/CN103908495B/en not_active Expired - Fee Related
- 2014-04-12 CN CN201510209341.4A patent/CN104771448A/en not_active Withdrawn
- 2014-04-12 CN CN201510209504.9A patent/CN104784259A/en not_active Withdrawn
- 2014-04-12 CN CN201510209544.3A patent/CN104771449A/en not_active Withdrawn
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| CN1840036A (en) * | 2005-03-29 | 2006-10-04 | 上海围城自由基生物工程研究所 | Chinese medicinal composite preparation capable of inhibiting growth of tumor cell |
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| CN104489516A (en) * | 2014-12-03 | 2015-04-08 | 姜秀清 | Health-preserving porridge capable of improving postoperative immune function of cancer paint and preparation method for health-preserving porridge |
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| Publication number | Publication date |
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| CN103908495B (en) | 2015-09-30 |
| CN104815008A (en) | 2015-08-05 |
| CN104771448A (en) | 2015-07-15 |
| CN104771449A (en) | 2015-07-15 |
| CN104784259A (en) | 2015-07-22 |
| CN104784260A (en) | 2015-07-22 |
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