CN104840937A - Traditional Chinese medicine preparation for treating osteoporosis - Google Patents

Abstract

The invention discloses a traditional Chinese medicine preparation for treating osteoporosis. The traditional Chinese medicine preparation is prepared according to repeated clinical experiment and verification and meets the theory of the traditional Chinese medicine. According to the traditional Chinese medicine preparation, prepared rehmannia roots, turtle shells, pulp of dogwood fruit, semen cuscutae, radix paeoniae alba, ox bone, Chinese yam, dried tangerine or orange peel, dried ginger, codonopsis pilosula, rhizoma cyperi, angelica sinensis and dates are taken as main and secondary medicines for nourishing the liver and the kidney and strengthening tendons and bones, cinnamon, lycium barbarum, eucommia ulmoides, atractylodes macrocephala, honey-fried licorice roots, aconite, as arum, scorpio, centipede, rhizoma cibotii, garden balsam stems, Sichuan pepper, carthamus tinctorius, pastinaca sativa and carrot are taken as assistant medicines for enhancing the effects of the main and secondary medicines, the medicines can be guided to straightly reach the disease parts, the effects of supplementing calcium, strengthening tendons and bones, tonifying the spleen and the kidney and activating the blood and circulating the tendon can be achieved when the medicines are combined, and due to the addition of dates and carrot, essential vitamins can be supplemented, and the effect of promoting calcium absorption can be achieved. The traditional Chinese medicine preparation disclosed by the invention has a unique treatment effect in treating osteoporosis and joint pain, and patients can be radically relieved from pain.

Description

A kind of Chinese medicine preparation for the treatment of osteoporosis

Technical field

The present invention relates to the field of Chinese medicines, specifically a kind of Chinese medicine preparation for the treatment of osteoporosis.

Background technology

Osteoporosis and osteoporosis, be one group of osteopathia that many reasons causes, osseous tissue has normal calcification, and calcium salt and substrate are normal rates, and the metabolic osteopathy being reduced to feature with unit volume inner bone tissues amount becomes.In most osteoporosis, caused by the minimizing of osseous tissue increases mainly due to bone absorption.With skeleton pain, be easy to fracture for feature.

Clinical manifestation:

1. pain

The modal symptom of primary osteoporosis, common with lumbago and backache, account for 70% ~ 80% in pain patients.Pain spreads along spinal column to both sides, lie on the back or seat time pain relief, stretch after time upright or standing for a long time, sitting time the pain increased, bend over, cough, increase the weight of when defecating firmly.Osteodynia can be there is when general bone loss more than 12%.During senile osteoporosis, Vertebral Compression is out of shape, flexion of vertebral column, and muscle fatigue is spasm even, produces pain.Recently compressed fracture of thoracic vertebra and lumber vertebra, also can produce acute pain, and the spinous process of corresponding site can have strong tenderness and percussion pain.If oppress corresponding spinal nerves can produce extremity radiating pain, two lower limb sensorimotor obstacle, intercostal neuralgia, the similar angina pectoris of retrosternal pain.If compressing spinal cord, cauda equina nerve also affect bladder, rectum function

2. height shortening, hunchback

How to occur after pain.The anterior loading weight of vertebra vertebral body is large, especially the 11st, 12 thoracic vertebras and the 3rd lumbar vertebra, loading is larger, easy compression, vertebra is leaned forward, formed bow-backed, with age, osteoporosis increases the weight of, bow-backed curvature strengthens, Vertebral Compression during senile osteoporosis, every vertebral body shortens 2 millimeter, height shorten in average 3 ~ 6 centimetres.

3. fracture

It is the most common and the most serious complication of degeneration osteoporosis.

4. respiratory function declines

Thoracolumbar vertebrae compression fracture, vertebra palintrope, chest deformity, can make vital capacity and maximal breathing capacity significantly reduce, patient often can occur uncomfortable in chest, breathe hard, the symptom such as dyspnea.

Chinese medicine does not have the title of osteoporosis, with regard to the feature of sings and symptoms, complication, can belong to " atrophic debility of bones ", " BI-syndrome involved the kidney " of Chinese medicine.Person of modern times is also called " weak bone disease ".

The method of current treatment osteoporosis has treatment by Chinese herbs, western medicine, acupuncture and moxibustion therapy, electrotherapy etc.Treatment by Chinese herbs is generally divided into oral medicine and medicine for external use two kinds, and clinical verification medicine for external use can only temporary relief pain, cannot effect a radical cure.Western medicine usually adopts antibiotic, aspirin and hormone anti-inflammatory analgetic, prints active rheumatism, can be eased, take stopgap measures and do not effect a permanent cure in the short time, and toxic and side effects is comparatively large, cannot be effected a radical cure.Although acupuncture and moxibustion therapy, electrotherapy have no side effect, medical expense is expensive, and treatment time is longer, brings very large inconvenience to the economy of patient with life.

Summary of the invention

The object of this invention is to provide a kind of Chinese medicine preparation for the treatment of osteoporosis.

A kind of Chinese medicine preparation for the treatment of osteoporosis of the present invention, is configured by clinic tests and repeated verification, meets the theory of Chinese medicine.With medicine nourishing the liver and kidney, bone and muscle strengthening that Radix Rehmanniae Preparata, Carapax Et Plastrum Testudinis, Fructus Corni, Semen Cuscutae, the Radix Paeoniae Alba, Os Bovis seu Bubali, Rhizoma Dioscoreae, Pericarpium Citri Reticulatae, Rhizoma Zingiberis, Radix Codonopsis, Rhizoma Cyperi, Radix Angelicae Sinensis, Fructus Jujubae are the monarch and his subjects; With Cortex Cinnamomi, Fructus Lycii, the Cortex Eucommiae, the Rhizoma Atractylodis Macrocephalae, Radix Glycyrrhizae Preparata, Aconitum carmichjaelii Debx., Herba Asari, Scorpio, Scolopendra, Rhizoma Cibotii, Herba speranskiae tuberculatae, Fructus Zanthoxyli, Flos Carthami, Radix Saposhnikoviae, the medicine of Radix Dauci Sativae for assisting a ruler in governing a country, strengthen effect of the medicine of the monarch and his subjects, all medicines are guided to go directly disease institute, all medicines share have replenish the calcium, bone and muscle strengthening, invigorating spleen and kidney, latus rectum of invigorating blood circulation effect, add Fructus Jujubae, Radix Dauci Sativae can supplement required vitamin, promote effect of calcium absorption.Chinese medicine preparation treatment osteoporosis of the present invention, arthralgia have unique curative effect, fundamentally relieve the misery of patient.

Treat a Chinese medicine preparation for osteoporosis, it is characterized in that, be made up of the raw material of following weight portion:

Radix Rehmanniae Preparata 30-40 part, Carapax Et Plastrum Testudinis 30-40 part, Fructus Corni 30-40 part, Semen Cuscutae 30-40 part, Radix Paeoniae Alba 30-40 part, Os Bovis seu Bubali 30-40 part, Rhizoma Dioscoreae 30-40 part, Pericarpium Citri Reticulatae 30-40 part, Rhizoma Zingiberis 30-40 part, Radix Codonopsis 30-40 part, Rhizoma Cyperi 30-40 part, Radix Angelicae Sinensis 30-40 part, Fructus Jujubae 30-40 part, Cortex Cinnamomi 20-30 part, Fructus Lycii 20-30 part, Cortex Eucommiae 20-30 part, Rhizoma Atractylodis Macrocephalae 20-30 part, Radix Glycyrrhizae Preparata 20-30 part, Aconitum carmichjaelii Debx. 20-30 part, Herba Asari 20-30 part, Scorpio 10-20 part, Scolopendra 10-20 part, Rhizoma Cibotii 30-40 part, Herba speranskiae tuberculatae 20-30 part, Fructus Zanthoxyli 20-30 part, Flos Carthami 20-30 part, Radix Saposhnikoviae 20-30 part, Radix Dauci Sativae 30-40 part.

Treat a Chinese medicine preparation for osteoporosis, it is characterized in that, be made up of the raw material of following weight portion:

Radix Rehmanniae Preparata 32-38 part, Carapax Et Plastrum Testudinis 32-38 part, Fructus Corni 32-38 part, Semen Cuscutae 32-38 part, Radix Paeoniae Alba 32-38 part, Os Bovis seu Bubali 32-38 part, Rhizoma Dioscoreae 32-38 part, Pericarpium Citri Reticulatae 32-38 part, Rhizoma Zingiberis 32-38 part, Radix Codonopsis 32-38 part, Rhizoma Cyperi 32-38 part, Radix Angelicae Sinensis 32-38 part, Fructus Jujubae 32-38 part, Cortex Cinnamomi 22-28 part, Fructus Lycii 22-28 part, Cortex Eucommiae 22-28 part, Rhizoma Atractylodis Macrocephalae 22-28 part, Radix Glycyrrhizae Preparata 22-28 part, Aconitum carmichjaelii Debx. 22-28 part, Herba Asari 22-28 part, Scorpio 12-18 part, Scolopendra 12-18 part, Rhizoma Cibotii 32-38 part, Herba speranskiae tuberculatae 22-28 part, Fructus Zanthoxyli 22-28 part, Flos Carthami 22-28 part, Radix Saposhnikoviae 22-28 part, Radix Dauci Sativae 32-38 part.

Treat a Chinese medicine preparation for osteoporosis, it is characterized in that, be made up of the raw material of following weight portion:

Radix Rehmanniae Preparata 35 parts, Carapax Et Plastrum Testudinis 35 parts, Fructus Corni 35 parts, Semen Cuscutae 35 parts, the Radix Paeoniae Alba 35 parts, Os Bovis seu Bubali 35 parts, Rhizoma Dioscoreae 35 parts, Pericarpium Citri Reticulatae 35 parts, Rhizoma Zingiberis 35 parts, Radix Codonopsis 35 parts, Rhizoma Cyperi 35 parts, Radix Angelicae Sinensis 35 parts, 35 parts, Fructus Jujubae, Cortex Cinnamomi 25 parts, Fructus Lycii 25 parts, the Cortex Eucommiae 25 parts, the Rhizoma Atractylodis Macrocephalae 25 parts, Radix Glycyrrhizae Preparata 25 parts, Aconitum carmichjaelii Debx. 25 parts, Herba Asari 25 parts, Scorpio 15 parts, Scolopendra 15 parts, Rhizoma Cibotii 35 parts, Herba speranskiae tuberculatae 25 parts, Fructus Zanthoxyli 25 parts, 25 parts, Flos Carthami, Radix Saposhnikoviae 25 parts, 35 parts, Radix Dauci Sativae.

Treat a Chinese medicine preparation for osteoporosis, it is characterized in that, the dosage form of endo-medicine preparation is honey refining pill, and its preparation method comprises:

By formula proportion, crude drug is added the 60-90% soak with ethanol 1-2 hour of 5-10 times amount, heating extraction 2 times, each 1-2 hour, remove supernatant, merge extractive liquid, 80-120 order filters, be the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.36 extractum, heating is concentrated, 30 minutes ~ 45 minutes, extract active ingredient, concentrated solution is settled into pasty state, and mass continues heating and is concentrated into extractum shape, adds Mel and is twisted into pill.

Usage and dosage: warm water takes, 3 times/day, 3 tablets/time, 4.5g/ grain.

Treat a Chinese medicine preparation for osteoporosis, it is characterized in that, the dosage form of endo-medicine preparation is capsule, and its preparation method comprises:

By formula proportion by all raw material stoving, be crushed to 300-400 order fine powder, incapsulate.

Treat a Chinese medicine preparation for osteoporosis, it is characterized in that, the dosage form of endo-medicine preparation is soup potus, and its preparation method comprises:

To add four times of water gagings after medicament mixed by formula proportion, after soaking half an hour, big fire changes slow fire into after boiling and simmers, and after 20 minutes, filtrate is for subsequent use, and medicinal residues continue to decoct with water 40 minutes waste filtrate, and twice filtrate merges, and obtains soup potus.

The present invention relates to pharmacology and the property of medicine of Chinese medicine:

Radix Rehmanniae Preparata:

[meridian distribution of property and flavor] is sweet, tepor; Return liver, kidney channel.

[function cures mainly] nourishing YIN and supplementing blood, beneficial essence fills out marrow.For the hepatic and renal YIN deficiency, soreness of the waist and knees, osteopyrexia and fever, night sweat is passed out semen, and interior-heat is quenched one's thirst, blood deficiency and yellow complexion, severe palpitation, menoxenia, and metrostaxis is dizzy, tinnitus, early whitening of beard and hair.

Carapax Et Plastrum Testudinis:

[meridian distribution of property and flavor] is salty, sweet, is slightly cold.Return liver, kidney, heart channel.

[function cures mainly] nourishing YIN for suppressing the hyperactive YANG, kidney tonifying bone strengthening, reinforcing the heart of nourishing blood.For deficiency of YIN hectic fever, hectic fever due to YIN-deficiency night sweat, has a dizzy spell, stirring-up of pathogenic wind in the interior resulting from deficiency, and muscles and bones flaccidity is soft, has a guilty conscience forgetful.

Mountain Fructus Corni: property is flat, sweet in the mouth, acid, function nourishing the liver and kidney, astringing YIN to stop sweating emergency treatment of collapse, is nourishing kidney yin key medicine, is mainly used in syndrome of yin deficiency of liver and kidney, is applicable to the soreness of the waist and knees caused by Liver and kidney two void, vertigo and tinnitus, sexual impotence, seminal emission, frequent micturition, the diseases such as incessant sweating due to debility.

Semen Cuscutae:

[nature and flavor] Gan Xinping, enters liver, kidney channel.

[function cures mainly] the kidney invigorating and essence nourishing, nourishing the liver to improve visual acuity, antiabortive.For caused by liver and kidney deficiency, soreness of waist and knee joint, impotence and seminal emission, frequent urination and enuresis, two blurred visions are dark, the diseases such as frequent fetal movement.

The Radix Paeoniae Alba:

[meridian distribution of property and flavor] acid, puts down and is slightly cold, slightly poisonous; Enter liver, spleen channel.

[function cures mainly] effect: nourishing blood to suppress the hyperactive liver, pain relieving in slow, yin fluid astringing receives antiperspirant; Control the breast abdomen pain over the hypochondriac region, dysentery is suffered from abdominal pain, spontaneous sweating, fever due to yin deficiency, menoxenia, metrorrhagia, leukorrhagia.

Os Bovis seu Bubali:

[nature and flavor] are sweet, temperature, nontoxic.

[return through] heart; Kidney; Large intestine channel

[function cures mainly] exempts from numbness; Preventing the attack (or recurrence) of malaria; Sore.Main joint is scorching; Dysentery; Malaria; Chancre

Rhizoma Dioscoreae:

[nature and flavor] sweet in the mouth, property are flat, enter lung, spleen, kidney channel;

[function cures mainly] has strengthening the spleen and tonifying the lung, stomach reinforcing the kidney invigorating, benefit of reinforcing the kidney essence, hearing-improing and eyesight improving, help the five internal organs, bone and muscle strengthening, long will are calmed the nerves, effect of life lengthening; Cure mainly that weakness of the spleen and stomach, lassitude, inappetence, chronic diarrhea and dysentery, insufficiency of lung-QI are dry, phlegm dyspnea cough, kidney qi loss, soreness of the waist and knees, lower limb flaccidity be weak, the red disease such as swollen, fat of frequent micturition of quenching one's thirst, seminal emission premature ejaculation, leukorrhagia nebulousurine, skin.

Pericarpium Citri Reticulatae:

[meridian distribution of property and flavor] is bitter, pungent, temperature; Return lung, spleen channel.

[function cures mainly] regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm.For fullness in the epigastrium and chest, lack of appetite and vomiting, cough with copious phlegm.

Rhizoma Zingiberis:

[meridian distribution of property and flavor] acrid in the mouth, tepor, nontoxic; Enter lung, the heart, stomach, spleen four warp.

[effect] is delivered, cold expelling, preventing or arresting vomiting, opens expectorant, carbuncle skin ulcer.

Radix Codonopsis:

[meridian distribution of property and flavor] sweet in the mouth, micro-acid, flat.Return spleen, lung meridian.

[function cures mainly] invigorating the spleen and replenishing QI, spleen invigorating lung benefiting.For deficiency of the spleen and lung, cardiopalmus of breathing hard, anorexia and loose stool, dyspnea due to deficiency is coughed, and interior-heat is quenched one's thirst.

Rhizoma Cyperi:

[nature and flavor] pungent micro-hardship is sweet, flat.

[function cures mainly] regulates the flow of vital energy resolving depression, menstruction regulating and pain relieving.For stagnation of QI due to depression of the liver, breast, the side of body, abdominal distention, dyspepsia, menoxenia, amenorrhea dysmenorrhea, colic of cold type is suffered from abdominal pain, distending pain of the breast.

Radix Angelicae Sinensis:

[nature and flavor] are warm in nature, hide sweet, pungent.

[function cures mainly] is enriched blood and is invigorated blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.For blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores.

Fructus Jujubae:

[meridian distribution of property and flavor] is sweet, and temperature, returns spleen, stomach warp;

[function cures mainly] invigorating the spleen and replenishing QI, nourishing blood to tranquillize the mind.For insufficiency of the spleen lack of appetite, weak loose stool, woman hysteria.

Cortex Cinnamomi:

[nature and flavor] extremely hot in nature, acrid in the mouth, sweet.

It is supporing yang that [function cures mainly] mends fire, let the fire back to its origin, dispersing cold for relieving pain, promoting blood circulation to restore menstrual flow.For sexual impotence, cold womb, trusted subordinate's cold type of pain, deficiency and coldness vomiting and diarrhoea, amenorrhea, dysmenorrhea, warming the meridian and promoting blood circulation.

Fructus Lycii:

[nature and flavor] are sweet, flat, enter liver, stomach two warp, double enter lung meridian;

[function cures mainly] the kidney invigorating and essence nourishing, nourishing the liver to improve visual acuity, blood-enriching tranquillizing, promoting the production of body fluid to quench thirst, nourishing the lung to arrest cough.Cure mainly: control apoplexy dizzy, asthenia, allly see blood disorder, cough blood, flaccidity, faint, contraction, disappear miasma, hinders dry, seminal emission, reddish and whitish turbid urine, beriberi, the arthroncus of knee.

The Cortex Eucommiae:

[meridian distribution of property and flavor] sweet in the mouth, hardship; Micro-pungent, temperature; Enter liver, kidney channel.

[function cures mainly] invigorating the liver and kidney, bone and muscle strengthening, antiabortive.Control spinal column ache, foot and knee flaccidity, dribbling urination, uncontrolled urination is itched, vaginal bleeding during pregnancy for falling, frequent fetal movement, hypertension.

The Rhizoma Atractylodis Macrocephalae:

[nature and flavor] are warm in nature, sweet in the mouth, hardship.

[effect] air making-up and spleen enlivening, can be used for asthenia weak breath, insufficiency of the spleen transporting mistake department.

Radix Glycyrrhizae Preparata:

[meridian distribution of property and flavor] sweet in the mouth, flat; GUIXIN, lung, spleen, stomach warp.

[function cures mainly] spleen reinforcing stomach function regulating, Yiqi and vein recovery.For weakness of the spleen and stomach, fatigue and weakness, severe palpitation, irregularly intermittent and regularly intermittent pulse, can separate Radix Aconiti Lateralis Preparata poison.

Aconitum carmichjaelii Debx.:

[nature and flavor] acrid in the mouth, hardship; Very toxic.

[function cures mainly] expelling wind and removing dampness, antalgic.Have a pain for anemofrigid-damp arthralgia, arthralgia, trusted subordinate's cold type of pain, colic of cold type.

Herba Asari:

[meridian distribution of property and flavor] acrid in the mouth, temperature, returns lung, kidney channel;

[function cures mainly] has expelling wind and cold, understand things pain-stopping, effect of warming the lung to resolve fluid-retention.

Scorpio:

[meridian distribution of property and flavor] acrid in the mouth is flat; Poisonous; Return Liver Channel.

[function cures mainly] endogenous wind stopping spasmolytic, dispersing pathogen accumulation, removing obstruction in the collateral to relieve pain.For infantile convulsion, tic spasm, middle air port is askew, hemiplegia, tetanus, rheumatoid arthritis stubborn, migraine and general headache, skin infection, scrofula.

Scolopendra:

[meridian distribution of property and flavor] acrid in the mouth, temperature; Poisonous; Return Liver Channel.

[function cures mainly] endogenous wind stopping spasmolytic, merit poison eliminating stagnation, removing obstruction in the collateral to relieve pain.For infantile convulsion, tic spasm, middle air port is askew, hemiplegia, tetanus, rheumatoid arthritis stubborn, skin infection, scrofula, venom.

Rhizoma Cibotii:

[meridian distribution of property and flavor] bitter in the mouth, sweet, temperature.Return liver, kidney channel.

[function cures mainly] invigorating the liver and kidney, strong spinal column, wind-damp dispelling.Aching and limp for spinal column, weakness of the lower extremities, rheumatic arthralgia.

Herba speranskiae tuberculatae:

[meridian distribution of property and flavor] sweet in the mouth, pungent, temperature, nontoxic.Enter lung, Liver Channel.

[function cures mainly] expelling wind and removing dampness, removing toxic substances pain relieving.For rheumatic arthritis; Sore swollen toxin is controlled in external.

Fructus Zanthoxyli:

[meridian distribution of property and flavor] is pungent, temperature.Return spleen, stomach, kidney channel.

[function cures mainly] warming middle-JIAO to relieve pain, killing parasites for relieving itching.For coldness and pain in the epigastrium, vomiting is had loose bowels, abdominal pain due to worm stagnation, ascariasis; External treatment eczema pruritus.

Flos Carthami:

[nature and flavor] are warm in nature, acrid in the mouth.

[function cures mainly] invigorates blood circulation latus rectum, eliminating stasis to stop pain.For amenorrhea, dysmenorrhea, lochia, lump in the abdomen mass in the abdomen, traumatic injury, be suitable for various varicosis, peripheral neuritis, blood circulation, lower limb numbness or the congestion such as livid purple.

Radix Saposhnikoviae:

[meridian distribution of property and flavor] acrid in the mouth, sweet, slightly warm in nature; Return bladder, liver, spleen channel.

[function] expelling pathogenic wind from the body surface, removing dampness to relieve pain, relieving convulsion.Diseases caused by exogenous pathogenic factor exterior syndrome, rubella pruritus, rheumatic arthralgia, tetanus.

Radix Dauci Sativae:

[nature and flavor] sweet in the mouth, property is put down.

[return through] enters lung, spleen channel.

[function cures mainly] strengthening the spleen to promote digestion, tonifying liver improving eyesight, heat-clearing and toxic substances removing, rash, sending down the abnormal ascending QI cough-relieving.For infantile malnutrition, measles, nyctalopia, constipation, hypertension, gastrointestinal upset, chronic dysentery, full stifling is swollen.Radix Dauci Sativae contains the nutrient such as more vitamin C, B1, B2, is described as " popular Radix Ginseng ".

detailed description of the invention:

Embodiment 1, formula:

Radix Rehmanniae Preparata 30g, Carapax Et Plastrum Testudinis 30g, Fructus Corni 30g, Semen Cuscutae 30g, Radix Paeoniae Alba 30g, Os Bovis seu Bubali 30g, Rhizoma Dioscoreae 30g, Pericarpium Citri Reticulatae 30g, Rhizoma Zingiberis 30g, Radix Codonopsis 30g, Rhizoma Cyperi 30g, Radix Angelicae Sinensis 30g, Fructus Jujubae 30g, Cortex Cinnamomi 20g, Fructus Lycii 20g, Cortex Eucommiae 20g, Rhizoma Atractylodis Macrocephalae 20g, Radix Glycyrrhizae Preparata 20g, Aconitum carmichjaelii Debx. 20g, Herba Asari 20g, Scorpio 10g, Scolopendra 10g, Rhizoma Cibotii 30g, Herba speranskiae tuberculatae 20g, Fructus Zanthoxyli 20g, Flos Carthami 20g, Radix Saposhnikoviae 20g, Radix Dauci Sativae 30g.

The dosage form of endo-medicine preparation is soup potus, and its preparation method comprises:

To add four times of water gagings after medicament mixed by formula proportion, after soaking half an hour, big fire changes slow fire into after boiling and simmers, and after 20 minutes, filtrate is for subsequent use, and medicinal residues continue to decoct with water 40 minutes waste filtrate, and twice filtrate merges, and obtains soup potus.

Embodiment 2: formula:

Radix Rehmanniae Preparata 32g, Carapax Et Plastrum Testudinis 32g, Fructus Corni 32g, Semen Cuscutae 32g, Radix Paeoniae Alba 32g, Os Bovis seu Bubali 32g, Rhizoma Dioscoreae 32g, Pericarpium Citri Reticulatae 32g, Rhizoma Zingiberis 32g, Radix Codonopsis 32g, Rhizoma Cyperi 32g, Radix Angelicae Sinensis 32g, Fructus Jujubae 32g, Cortex Cinnamomi 22g, Fructus Lycii 22g, Cortex Eucommiae 22g, Rhizoma Atractylodis Macrocephalae 22g, Radix Glycyrrhizae Preparata 22g, Aconitum carmichjaelii Debx. 22g, Herba Asari 22g, Scorpio 12g, Scolopendra 12g, Rhizoma Cibotii 32g, Herba speranskiae tuberculatae 22g, Fructus Zanthoxyli 22g, Flos Carthami 22g, Radix Saposhnikoviae 22g, Radix Dauci Sativae 32g.

The dosage form of endo-medicine preparation is capsule, and its preparation method comprises:

By formula proportion by all raw material stoving, be crushed to 300-400 order fine powder, incapsulate.

Usage and dosage: warm water takes, 3 times/day, 3 tablets/time, 4.5g/ grain.

Embodiment 3, formula:

Radix Rehmanniae Preparata 35g, Carapax Et Plastrum Testudinis 35g, Fructus Corni 35g, Semen Cuscutae 35g, Radix Paeoniae Alba 35g, Os Bovis seu Bubali 35g, Rhizoma Dioscoreae 35g, Pericarpium Citri Reticulatae 35g, Rhizoma Zingiberis 35g, Radix Codonopsis 35g, Rhizoma Cyperi 35g, Radix Angelicae Sinensis 35g, Fructus Jujubae 35g, Cortex Cinnamomi 25g, Fructus Lycii 25g, Cortex Eucommiae 25g, Rhizoma Atractylodis Macrocephalae 25g, Radix Glycyrrhizae Preparata 25g, Aconitum carmichjaelii Debx. 25g, Herba Asari 25g, Scorpio 15g, Scolopendra 15g, Rhizoma Cibotii 35g, Herba speranskiae tuberculatae 25g, Fructus Zanthoxyli 25g, Flos Carthami 25g, Radix Saposhnikoviae 25g, Radix Dauci Sativae 35g.

The dosage form of endo-medicine preparation is honey refining pill, and its preparation method comprises:

By formula proportion, crude drug is added the 60-90% soak with ethanol 1-2 hour of 5-10 times amount, heating extraction 2 times, each 1-2 hour, remove supernatant, merge extractive liquid, 80-120 order filters, be the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.36 extractum, heating is concentrated, 30 minutes ~ 45 minutes, extract active ingredient, concentrated solution is settled into pasty state, and mass continues heating and is concentrated into extractum shape, adds Mel and is twisted into pill.

Usage and dosage: warm water takes, 3 times/day, 3 tablets/time, 4.5g/ grain.

Embodiment 4, formula:

Radix Rehmanniae Preparata 38g, Carapax Et Plastrum Testudinis 38g, Fructus Corni 38g, Semen Cuscutae 38g, Radix Paeoniae Alba 38g, Os Bovis seu Bubali 38g, Rhizoma Dioscoreae 38g, Pericarpium Citri Reticulatae 38g, Rhizoma Zingiberis 38g, Radix Codonopsis 38g, Rhizoma Cyperi 38g, Radix Angelicae Sinensis 38g, Fructus Jujubae 38g, Cortex Cinnamomi 28g, Fructus Lycii 28g, Cortex Eucommiae 28g, Rhizoma Atractylodis Macrocephalae 28g, Radix Glycyrrhizae Preparata 28g, Aconitum carmichjaelii Debx. 28g, Herba Asari 28g, Scorpio 18g, Scolopendra 18g, Rhizoma Cibotii 38g, Herba speranskiae tuberculatae 28g, Fructus Zanthoxyli 28g, Flos Carthami 28g, Radix Saposhnikoviae 28g, Radix Dauci Sativae 38g.

The dosage form of endo-medicine preparation is capsule, and its preparation method comprises:

By formula proportion by all raw material stoving, be crushed to 300-400 order fine powder, incapsulate.

Usage and dosage: warm water takes, 3 times/day, 3 tablets/time, 4.5g/ grain.

Embodiment 5, formula:

Radix Rehmanniae Preparata 40g, Carapax Et Plastrum Testudinis 40g, Fructus Corni 40g, Semen Cuscutae 40g, Radix Paeoniae Alba 40g, Os Bovis seu Bubali 40g, Rhizoma Dioscoreae 40g, Pericarpium Citri Reticulatae 40g, Rhizoma Zingiberis 40g, Radix Codonopsis 40g, Rhizoma Cyperi 40g, Radix Angelicae Sinensis 40g, Fructus Jujubae 40g, Cortex Cinnamomi 30g, Fructus Lycii 30g, Cortex Eucommiae 30g, Rhizoma Atractylodis Macrocephalae 30g, Radix Glycyrrhizae Preparata 30g, Aconitum carmichjaelii Debx. 30g, Herba Asari 30g, Scorpio 20g, Scolopendra 20g, Rhizoma Cibotii 40g, Herba speranskiae tuberculatae 30g, Fructus Zanthoxyli 30g, Flos Carthami 30g, Radix Saposhnikoviae 30g, Radix Dauci Sativae 40g.

The dosage form of endo-medicine preparation is soup potus, and its preparation method comprises:

To add four times of water gagings after medicament mixed by formula proportion, after soaking half an hour, big fire changes slow fire into after boiling and simmers, and after 20 minutes, filtrate is for subsequent use, and medicinal residues continue to decoct with water 40 minutes waste filtrate, and twice filtrate merges, and obtains soup potus.

Pharmacology pharmacodynamic is tested:

1, acute toxicity test

Application mice carries out acute toxicity testing and shows: Mouse oral gavage Chinese medicine preparation of the present invention, under 488.8g crude drug/kg dosage, after administration, mice occurs that light activity reduces, 1 hours recovers normal, Continuous Observation 7 days after administration, none animal dead, its overall health of patients, diet, take the photograph water, urine and body weight increase all normal, experimental result shows: the maximum dosage-feeding of Mouse oral gavage Chinese medicine preparation of the present invention is 488.8g crude drug/kg/d (LD 50 > 488.8g crude drug/kg).Chinese medicine preparation clinical application every day total amount of the present invention is 0.1g crude drug/kg/d; By weighing machine, the dosis tolerata of mouse stomach Chinese medicine preparation of the present invention is 4888 times of clinical patient.Point out this medicine acute toxicity low, clinical drug safety.

2, long term toxicity test

Select SD rat, give the Chinese medicine preparation of the present invention of variable concentrations (18.0,6.0,2.0g crude drug/kg), every day gavage once, continuous 90 days, within after last administration 24 hours, respectively group is alive kills 1/2 animal (male and female half and half), and all the other 1/2 animals continue observations 2 weeks rear living and kill.Duration of test observes outward appearance, general behavior, food ration, the body weight change of animal, within after administration 90 days, within 2 weeks, carries out the index checking such as hematology's (RBC, HB, reticulocyte, PLT, CT, WBC and classification) and blood biochemical (AST, ALT, ALP, Glu, BUN, Crea, TP, T.BIL, ALB, CHOL), urine biochemistry, organ coefficient, histopathology with drug withdrawal.Result of the test shows: invention formulation is good at high, medium and low dosage treated animal general state, and outward appearance sign, behavioral activity, food-intake and body weight increase change all without exception; Three dosage groups and matched group hematological examination, blood biochemical analysis, urine biochemical analysis all in normal range, without significant difference between group; Each group of main organs histopathological examination shows no obvious abnormalities.These parameters drug withdrawal also had no change after 2 weeks.This test dosage is respectively 180,60,20 times of clinical medicine dose, rat is had no significant effect in high, medium and low three dosage (18.0,6.0,2.0g crude drug/kg) administration in continuous 90 days according to result of the test Chinese medicine preparation of the present invention, without clear and definite toxicity target organ and sensitive indicator, convalescent period observation also has no retardance toxic reaction, points out the dose safety of Chinese medicine preparation clinical practice of the present invention higher.

3, animal local excitation test:

The allergic reaction on guinea pigs of Chinese medicine preparation of the present invention and Chinese medicine preparation Rat-rectum medication irritation test.Result shows: skin anaphylactic test, high dose group 0.8g (medicated powder)/kg, low dose group 0.1g (medicated powder)/kg, be equivalent to 20 times, 2.5 times that intend clinical people's consumption [0.04g (medicated powder)/kg] respectively, through percutaneous drug delivery, be showed no animal and produce allergy; Rectal application irritation test high dose group 5.0g (medicated powder)/kg, low dose group 3.2g (medicated powder)/kg, be equivalent to 125,80 times that intend clinical people's consumption respectively, mucous membrane of rectum is observed all without phenomenons such as hyperemia, edema in official hour, histopathologic examination compares no significant difference with blank group, have no and occur obvious irritative response, often organize its overall health of patients of Some Animals of retention, body weight, breathing, circulation, central nervous system and extremity are movable, equal Non Apparent Abnormality reaction.

clinical data

1 object and method

1.1 subject patient 200 examples, are divided into matched group 5O example at random, treatment group 150 example.

1.2 diagnostic criterias are with reference to " osteoporosis science " clinical manifestations: (1), bone pantalgia, based on spinal column and pelvis and fracture, when change position or upper and lower stair more very.

(2), stature becomes short.

(3), easily fracture.

1.3 Therapeutic Method treatment groups: take medicinal preparation for oral administration of the present invention, matched group: vitamin D and calcium preparation, the oral class tablet+massage+hot compress that relieves the pain

1.4 efficacy assessment standards (1) clinical recovery: clinical symptoms, sign disappear, follows up a case by regular visits to 3 months without recurrence.(2) effective: symptom obviously takes effect.(3) effective: clinical symptoms is slightly improved.(4) invalid: clinical symptoms, sign are without change.

I.5 statistical procedures uses SPSS 12.0 software to carry out statistical analysis, and ask that mean compares employing one factor analysis of variance for each group, group is asked and compared employing between two.Inspection.P<0.05 is that difference has significance.

2 results

Matched group recovery from illness 22 example, accounts for 44%; Effective 11 examples, account for 22%; Effective 8 examples, account for 16%; No effect 9, accounts for 18%, total effective rate 82%.

Treatment group recovery from illness 98 example, accounts for 65.33%; Effective 32 examples, account for 21.33%; Effective 15 examples, account for 10%; Invalid 5 examples, account for 3.33%.Total effective rate accounts for 96.66%.

Significance (P<O.05) is had through checking two groups of differences.

Claims (6)

1. treat a Chinese medicine preparation for osteoporosis, it is characterized in that, be made up of the raw material of following weight portion:

Radix Rehmanniae Preparata 30-40 part, Carapax Et Plastrum Testudinis 30-40 part, Fructus Corni 30-40 part, Semen Cuscutae 30-40 part, Radix Paeoniae Alba 30-40 part, Os Bovis seu Bubali 30-40 part, Rhizoma Dioscoreae 30-40 part, Pericarpium Citri Reticulatae 30-40 part, Rhizoma Zingiberis 30-40 part, Radix Codonopsis 30-40 part, Rhizoma Cyperi 30-40 part, Radix Angelicae Sinensis 30-40 part, Fructus Jujubae 30-40 part, Cortex Cinnamomi 20-30 part, Fructus Lycii 20-30 part, Cortex Eucommiae 20-30 part, Rhizoma Atractylodis Macrocephalae 20-30 part, Radix Glycyrrhizae Preparata 20-30 part, Aconitum carmichjaelii Debx. 20-30 part, Herba Asari 20-30 part, Scorpio 10-20 part, Scolopendra 10-20 part, Rhizoma Cibotii 30-40 part, Herba speranskiae tuberculatae 20-30 part, Fructus Zanthoxyli 20-30 part, Flos Carthami 20-30 part, Radix Saposhnikoviae 20-30 part, Radix Dauci Sativae 30-40 part.

2. a kind of Chinese medicine preparation for the treatment of osteoporosis according to claim 1, is characterized in that, be made up of the raw material of following weight portion:

Radix Rehmanniae Preparata 32-38 part, Carapax Et Plastrum Testudinis 32-38 part, Fructus Corni 32-38 part, Semen Cuscutae 32-38 part, Radix Paeoniae Alba 32-38 part, Os Bovis seu Bubali 32-38 part, Rhizoma Dioscoreae 32-38 part, Pericarpium Citri Reticulatae 32-38 part, Rhizoma Zingiberis 32-38 part, Radix Codonopsis 32-38 part, Rhizoma Cyperi 32-38 part, Radix Angelicae Sinensis 32-38 part, Fructus Jujubae 32-38 part, Cortex Cinnamomi 22-28 part, Fructus Lycii 22-28 part, Cortex Eucommiae 22-28 part, Rhizoma Atractylodis Macrocephalae 22-28 part, Radix Glycyrrhizae Preparata 22-28 part, Aconitum carmichjaelii Debx. 22-28 part, Herba Asari 22-28 part, Scorpio 12-18 part, Scolopendra 12-18 part, Rhizoma Cibotii 32-38 part, Herba speranskiae tuberculatae 22-28 part, Fructus Zanthoxyli 22-28 part, Flos Carthami 22-28 part, Radix Saposhnikoviae 22-28 part, Radix Dauci Sativae 32-38 part.

3. a kind of Chinese medicine preparation for the treatment of osteoporosis according to claim 1, is characterized in that, be made up of the raw material of following weight portion:

Radix Rehmanniae Preparata 35 parts, Carapax Et Plastrum Testudinis 35 parts, Fructus Corni 35 parts, Semen Cuscutae 35 parts, the Radix Paeoniae Alba 35 parts, Os Bovis seu Bubali 35 parts, Rhizoma Dioscoreae 35 parts, Pericarpium Citri Reticulatae 35 parts, Rhizoma Zingiberis 35 parts, Radix Codonopsis 35 parts, Rhizoma Cyperi 35 parts, Radix Angelicae Sinensis 35 parts, 35 parts, Fructus Jujubae, Cortex Cinnamomi 25 parts, Fructus Lycii 25 parts, the Cortex Eucommiae 25 parts, the Rhizoma Atractylodis Macrocephalae 25 parts, Radix Glycyrrhizae Preparata 25 parts, Aconitum carmichjaelii Debx. 25 parts, Herba Asari 25 parts, Scorpio 15 parts, Scolopendra 15 parts, Rhizoma Cibotii 35 parts, Herba speranskiae tuberculatae 25 parts, Fructus Zanthoxyli 25 parts, 25 parts, Flos Carthami, Radix Saposhnikoviae 25 parts, 35 parts, Radix Dauci Sativae.

4. a kind of Chinese medicine preparation for the treatment of osteoporosis according to claim 1-3 any one, is characterized in that, the dosage form of endo-medicine preparation is honey refining pill, and its preparation method comprises:

By formula proportion, crude drug is added the 60-90% soak with ethanol 1-2 hour of 5-10 times amount, heating extraction 2 times, each 1-2 hour, remove supernatant, merge extractive liquid, 80-120 order filters, be the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.36 extractum, heating is concentrated, 30 minutes ~ 45 minutes, extract active ingredient, concentrated solution is settled into pasty state, and mass continues heating and is concentrated into extractum shape, adds Mel and is twisted into pill;

Usage and dosage: warm water takes, 3 times/day, 3 tablets/time, 4.5g/ grain.

5. a kind of Chinese medicine preparation for the treatment of osteoporosis according to claim 1-3 any one, is characterized in that, the dosage form of endo-medicine preparation is capsule, and its preparation method comprises:

By formula proportion by all raw material stoving, be crushed to 300-400 order fine powder, incapsulate.

6. a kind of Chinese medicine preparation for the treatment of osteoporosis according to claim 1-3 any one, is characterized in that, the dosage form of endo-medicine preparation is soup potus, and its preparation method comprises:

To add four times of water gagings after medicament mixed by formula proportion, after soaking half an hour, big fire changes slow fire into after boiling and simmers, and after 20 minutes, filtrate is for subsequent use, and medicinal residues continue to decoct with water 40 minutes waste filtrate, and twice filtrate merges, and obtains soup potus.