CN105617388A - Kidney-tonifying yang-strengthening medicine composition - Google Patents

Abstract

The invention discloses a kidney-tonifying yang-strengthening medicine composition. The medicine composition is mainly prepared from, by weight, 5-20 parts of hirudo, 80-110 parts of Herba epimedii, 15-28 parts of Herba cistanche, 20-30 parts of penis cervi, 8-12 parts of pilose antler, 18-22 parts of gecko, 2-6 parts of gecko male testicle, 15-30 parts of Radix ginseng, 15-28 parts of Hippocampus japonicus, 12-25 parts of Herba cynomorii, 5-12 parts of Eurycoma longifolia, 15-30 parts of oyster, 30-40 parts of Radix codonopsis, 1-3 parts of Semen juglandis, 10-15 parts of Rhizoma dioscoreae, 22-36 parts of Radix glycyrrhizae and 10-15 parts of lumbrukinase. Through reasonable compatibility of medicine, the objectives of building body, tonifying kidney, strengthening yang and improving human immunity.

Description

A kind of pharmaceutical composition of kidney invigorating and YANG supporting

Technical field

The present invention relates to pharmaceutical technology field, particularly the pharmaceutical composition of a kind of kidney invigorating and YANG supporting.

Background technology

Quickening along with modern life rhythm, irregular, life that overfatigue, pressure are excessive for a long time, it is easily caused the human body functional disorder of people, shows as the symptoms such as insufficiency of kidney-YANG, blood and essence asthenia, soreness of waist and knee joint, extremity cold, fatigue and asthenia, impotence and premature ejaculation, early whitening of beard and hair. People are for building body, kidney invigorating and YANG supporting, medicine or the health product that can select some kidney invigorating and YANG supporting are taken, but, the medea that the traditional Chinese medical science or doctor trained in Western medicine develop now is various in style, but due to medea market, dragons and fishes jumbled together, the composition of medea is indefinite so that a lot of user all has doubt for medea and kidney-reinforcing drug.

Summary of the invention

The invention provides the pharmaceutical composition of a kind of kidney invigorating and YANG supporting, it is possible to building body, kidney invigorating and YANG supporting, raising body immunity.

For achieving the above object, the technical scheme is that

A kind of pharmaceutical composition of kidney invigorating and YANG supporting, it is mainly made up by weight ratio of following components:

Hirudo 5 ~ 20 parts, Herba Epimedii 80 ~ 110, Herba Cistanches 15 ~ 28 parts, Penis et testis cervi 20 ~ 30 parts, 8 ~ 12 parts of Cornu Cervi Pantotrichum, Gecko 18 ~ 28 parts, Gecko hero testis 2 ~ 6 parts, Radix Ginseng 15 ~ 30 parts, Hippocampus 15 ~ 28 parts, Herba Cynomorii 12 ~ 25 parts, Eurycoma longifolia 5 ~ 12 parts, Concha Ostreae 15 ~ 30 parts, Radix Codonopsis 30 ~ 40 parts, Partition in Fructus Juglandis 1 ~ 3 part, Rhizoma Dioscoreae 10 ~ 15 parts, 22 ~ 36 parts of Radix Glycyrrhizae, Lumbrukinase 10 ~ 15 parts.

The pharmaceutical composition of above-described kidney invigorating and YANG supporting, it is preferable that be mainly made up by weight ratio of following components:

Hirudo 12 parts, Herba Epimedii 105, Herba Cistanches 22 parts, Penis et testis cervi 25 parts, 10 parts of Cornu Cervi Pantotrichum, Gecko 23 parts, Gecko hero testis 4 parts, Radix Ginseng 23 parts, Hippocampus 23 parts, Herba Cynomorii 19 parts, Eurycoma longifolia 8 parts, Concha Ostreae 24 parts, Radix Codonopsis 35 parts, Partition in Fructus Juglandis 2 parts, Rhizoma Dioscoreae 13 parts, 31 parts of Radix Glycyrrhizae, Lumbrukinase 13 parts.

The above pharmaceutical composition can add customary adjuvant by practice of pharmacy and make any dosage form of clinical acceptance; It is capsule as preferred described dosage form.

The preparation method of the pharmaceutical composition of above-described kidney invigorating and YANG supporting, comprises the following steps:

(1) following component is weighed by weight: Hirudo 5 ~ 20 parts, Herba Epimedii 80 ~ 110, Herba Cistanches 15 ~ 28 parts, Penis et testis cervi 20 ~ 30 parts, 8 ~ 12 parts of Cornu Cervi Pantotrichum, Gecko 18 ~ 28 parts, Gecko hero testis 2 ~ 6 parts, Radix Ginseng 15 ~ 30 parts, Hippocampus 15 ~ 28 parts, Herba Cynomorii 12 ~ 25 parts, Eurycoma longifolia 5 ~ 12 parts, Concha Ostreae 15 ~ 30 parts, Radix Codonopsis 30 ~ 40 parts, Partition in Fructus Juglandis 1 ~ 3 part, Rhizoma Dioscoreae 10 ~ 15 parts, 22 ~ 36 parts of Radix Glycyrrhizae, Lumbrukinase 10 ~ 15 parts;

(2) Cornu Cervi Pantotrichum and Radix Ginseng grind into powder respectively;

(3) Hirudo, Penis et testis cervi, Gecko, Gecko hero testis, Hippocampus, adding 4 ~ 6 times of weight concentrations of above-mentioned each component weight is the ethanol of 70 ~ 80%, heating and refluxing extraction 2 ~ 3 times, each 2 ~ 5 hours, gradation filtered, merging filtrate, concentration, reclaims ethanol, obtains concentrated solution A; Standby;

(4) Herba Epimedii, Herba Cistanches, Herba Cynomorii, Eurycoma longifolia, Concha Ostreae, Radix Codonopsis, Partition in Fructus Juglandis, Rhizoma Dioscoreae and Radix Glycyrrhizae, add the water of above-mentioned 6 ~ 10 times of weight of each component weight, heating extraction 2 ~ 3 times, each 1 ~ 2 hour, gradation filtered, merging filtrate, add concentrated solution A, be condensed into thick paste, add Pilose Antler, Radix Ginseng powder and appropriate amount of starch, dry, pulverizing, get dry extract powder;

(5) take dried cream powder and add starch slurry, magnesium stearate and microcrystalline Cellulose, mixing, make granule, load capsule, obtain capsule.

The pharmaceutical composition of the present invention is mainly made up of Hirudo, Herba Epimedii, Herba Cistanches, Penis et testis cervi, Cornu Cervi Pantotrichum, Gecko, Gecko hero testis, Radix Ginseng, Hippocampus, Herba Cynomorii, Eurycoma longifolia, Concha Ostreae, Radix Codonopsis, Partition in Fructus Juglandis, Rhizoma Dioscoreae, Radix Glycyrrhizae and Lumbrukinase, and in side, effect of each medicine is:

Hirudo: the salty hardship of nature and flavor, flat; Have invigorate blood circulation, effect of dissipating blood stasis, the clear stasis of blood, can be used for treating amenorrhea, traumatic injury etc.;

Herba Epimedii: nature and flavor are pungent, sweet, temperature, there is kidney invigorating and YANG supporting, bone and muscle strengthening, invigorate vital energy and reinforce the heart, effect of expelling wind and removing dampness, it is adaptable to the soft disease such as unable for the treatment of sexual impotence, seminal emission, premature ejaculation, sexual disorder, menoxenia, climacteric syndrome, hypertension, rheumatalgia, hemiplegia, numb limbs and tense tendons, knee joint;

Herba Cistanches: meridian distribution of property and flavor is sweet, salty, temperature; Function cures mainly kidney-replenishing, benefiting essence-blood, loosening bowel to relieve constipation; For sexual impotence, infertile, soreness of the waist and knees, muscles and bones is unable, dryness of the intestine constipation;

Penis et testis cervi: warm in nature, salty in the mouth is pungent, nontoxic; The kidney invigorating essence, invigorating kidney-YANG, benefit essence, strong waist knee joint; Curing mainly strain of suffering from a deficiency of the kidney, soreness of waist and knee joint, deafness and tinnitus, sexual impotence, seminal emission, premature ejaculation, cold womb is infertile, and leukorrhagia is rare clearly;

Cornu Cervi Pantotrichum: warm in nature and not dry, has and rouses oneself and improve body function, to patient after asthenia universalis, prolonged illness, have good Tonic Action; Li Shizhen (1518-1593 A.D.) claims Cornu Cervi Pantotrichum " being good at kidney invigorating and YANG supporting, spermatogenesis benefit blood, the strong bone of benefit marrow " in Compendium of Material Medica;

Gecko: " detailed outline " is recorded, tonifying the lung gas, benefiting essence-blood, Dingchuan antitussive, treats lung abscess and quenches one's thirst, supporing yang road; " book on Chinese herbal medicine is new again " is recorded, warming middle-JIAO kidney tonifying, and controlling nocturnal emission with astringent drugs is supporing yang, treating stranguria, promoting the circulation of blood;

Gecko hero testis: i.e. Gecko testis, has kidney invigorating and YANG supporting, tonifying the lung Dingchuan, blood nourishing body building, anti-ageing effect prolonged life;

Radix Ginseng: Radix Ginseng is described as " king of BAICAO " from ancient times, is the superfine product of " YIN nourishing is mended raw, strengthening the body resistance ", containing multiple Saponin and polysaccharide composition, leachate slowly can be absorbed by skin and without pessimal stimulation, energy skin expansion blood capillary, promote cutaneous circulation, increase skin-nourishing; The fleshy tap root of Radix Ginseng is famous strong tonic, it is adaptable to adjusts blood pressure, recover the diseases such as cardiac function, neurasthenia and physical weakness, also eliminate the phlegm, stomach invigorating, diuresis, the effect such as excitement;

Hippocampus: there is the medicinal efficacies such as building body, kidney invigorating and YANG supporting, relaxing muscles and tendons and activating QI and blood in the collateral, anti-inflammatory analgetic, tranquillizing and allaying excitement, relieving cough and asthma;

Herba Cynomorii: can the kidney invigorating, benefit essence, moisturize, cure mainly impotence and seminal emission, soreness of the waist and knees, dryness of the intestine constipation, to paralysis with improve that sexual function is weak to have certain effect;

Eurycoma longifolia: bitter in the mouth, cool in nature, it is referred to as " natural philter ", there is effect of heat clearing away, preventing the attack (or recurrence) of malaria, dampness removing jaundice eliminating, tonifying YANG;

Concha Ostreae: nature and flavor are salty, is slightly cold; There are convergence, calmness, removing toxic substances, analgesic effect; Rich in new element, the vigor of mankind spermatozoon can be improved;

Radix Codonopsis: sweet in the mouth, has effect of invigorating the spleen and replenishing QI, spleen invigorating lung benefiting, anticancer, blood pressure lowering, anti-hypoxia, defying age, it is also possible to strengthen body immunity, improves the activity of superoxide dismutase, strengthens the ability eliminating free radical; With ginseng compatibility can invigorating the spleen to benefit the lung, promote the production of body fluid and nourish blood;

Partition in Fructus Juglandis: reinforcing the kindey to control nocturnal emission; Control seminal emission lingering diarrhea, gonorrhea, hematuria, incontinence of urine, metrorrhagia, leukorrhagia, dysentery;

Rhizoma Dioscoreae: there is nourishing strong, aid digestion, hold back sweating due to debility, effect of antidiarrheal, cure mainly insufficiency of the spleen diarrhoea, cough due to deficiency of the lung, diabetes are quenched one's thirst, oliguria frequency, seminal emission;

Radix Glycyrrhizae: there is many-sided effects such as invigorating the spleen and replenishing QI, nourishing the lung to arrest cough, eliminating fire and detoxication, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription;

Lumbrukinase: there is thrombolytic, anticoagulant and go fine effect; Lumbrukinase is the proteolytic enzyme that activity is the highest, can the various cell of human activin.

The present invention is the kidney invigorating gas with Herba Epimedii, Herba Cistanches, Penis et testis cervi, Cornu Cervi Pantotrichum, Gecko, Gecko hero testis, Hippocampus, Herba Cynomorii, Eurycoma longifolia, Partition in Fructus Juglandis, supports the principal agent of essence and blood, tonifying YANG, assistant is with the Hirudo Activating stasis of blood, help and improve motility of sperm with Concha Ostreae, help with Radix Ginseng, Radix Codonopsis, Rhizoma Dioscoreae, Radix Glycyrrhizae invigorating the spleen and replenishing QI, hold up this solid just, separately also have and be equipped with Lumbrukinase active cell activity, the present invention reasonable compatibility by said medicine, reaches the purpose of building body, kidney invigorating and YANG supporting, raising body immunity.

Detailed description of the invention

Below in conjunction with specific embodiment, the invention will be further described, but protection scope of the present invention is not limited to following example:

One, the preparation of the pharmaceutical composition of kidney invigorating and YANG supporting

Embodiment 1

The pharmaceutical composition of a kind of kidney invigorating and YANG supporting, is mainly made up by weight ratio of following components: Hirudo 12 parts, Herba Epimedii 105, Herba Cistanches 22 parts, Penis et testis cervi 25 parts, 10 parts of Cornu Cervi Pantotrichum, Gecko 23 parts, Gecko hero testis 4 parts, Radix Ginseng 23 parts, Hippocampus 23 parts, Herba Cynomorii 19 parts, Eurycoma longifolia 8 parts, Concha Ostreae 24 parts, Radix Codonopsis 35 parts, Partition in Fructus Juglandis 2 parts, Rhizoma Dioscoreae 13 parts, 31 parts of Radix Glycyrrhizae, Lumbrukinase 13 parts.

The preparation method of aforementioned pharmaceutical compositions is:

(1) said components is weighed by weight;

(2) Cornu Cervi Pantotrichum and Radix Ginseng grind into powder respectively;

(3) Hirudo, Penis et testis cervi, Gecko, Gecko hero testis, Hippocampus, adding 4 ~ 6 times of weight concentrations of above-mentioned each component weight is the ethanol of 70 ~ 80%, heating and refluxing extraction 2 ~ 3 times, each 2 ~ 5 hours, gradation filtered, merging filtrate, concentration, reclaims ethanol, obtains concentrated solution A; Standby;

(4) Herba Epimedii, Herba Cistanches, Herba Cynomorii, Eurycoma longifolia, Concha Ostreae, Radix Codonopsis, Partition in Fructus Juglandis, Rhizoma Dioscoreae and Radix Glycyrrhizae, add the water of above-mentioned 6 ~ 10 times of weight of each component weight, heating extraction 2 ~ 3 times, each 1 ~ 2 hour, gradation filtered, merging filtrate, add concentrated solution A, be condensed into thick paste, add Pilose Antler, Radix Ginseng powder, Lumbrukinase and appropriate amount of starch, dry, pulverizing, get dry extract powder;

(5) take dried cream powder and add starch slurry, magnesium stearate and microcrystalline Cellulose, mixing, make granule, load capsule, obtain capsule.

Embodiment 2

The pharmaceutical composition of a kind of kidney invigorating and YANG supporting, is mainly made up by weight ratio of following components: Hirudo 5 parts, Herba Epimedii 80, Herba Cistanches 15 parts, Penis et testis cervi 20 parts, 8 parts of Cornu Cervi Pantotrichum, Gecko 18 parts, Gecko hero testis 2 parts, Radix Ginseng 15 parts, Hippocampus 15 parts, Herba Cynomorii 12 parts, Eurycoma longifolia 5 parts, Concha Ostreae 15 parts, Radix Codonopsis 30 parts, Partition in Fructus Juglandis 1 part, Rhizoma Dioscoreae 10 parts, 22 parts of Radix Glycyrrhizae, Lumbrukinase 10 parts.

The preparation method of aforementioned pharmaceutical compositions is:

(1) said components is weighed by weight;

(2) Cornu Cervi Pantotrichum and Radix Ginseng grind into powder respectively;

(3) Hirudo, Penis et testis cervi, Gecko, Gecko hero testis, Hippocampus, adding 4 ~ 6 times of weight concentrations of above-mentioned each component weight is the ethanol of 70 ~ 80%, heating and refluxing extraction 2 ~ 3 times, each 2 ~ 5 hours, gradation filtered, merging filtrate, concentration, reclaims ethanol, obtains concentrated solution A; Standby;

(4) Herba Epimedii, Herba Cistanches, Herba Cynomorii, Eurycoma longifolia, Concha Ostreae, Radix Codonopsis, Partition in Fructus Juglandis, Rhizoma Dioscoreae and Radix Glycyrrhizae, add the water of above-mentioned 6 ~ 10 times of weight of each component weight, heating extraction 2 ~ 3 times, each 1 ~ 2 hour, gradation filtered, merging filtrate, add concentrated solution A, be condensed into thick paste, add Pilose Antler, Radix Ginseng powder, Lumbrukinase and appropriate amount of starch, dry, pulverizing, get dry extract powder;

(5) take dried cream powder and add starch slurry, magnesium stearate and microcrystalline Cellulose, mixing, make granule, load capsule, obtain capsule.

Embodiment 3

The pharmaceutical composition of a kind of kidney invigorating and YANG supporting, is mainly made up by weight ratio of following components: Hirudo 20 parts, Herba Epimedii 110, Herba Cistanches 28 parts, Penis et testis cervi 30 parts, 12 parts of Cornu Cervi Pantotrichum, Gecko 28 parts, Gecko hero testis 6 parts, Radix Ginseng 30 parts, Hippocampus 28 parts, Herba Cynomorii 25 parts, Eurycoma longifolia 12 parts, Concha Ostreae 30 parts, Radix Codonopsis 40 parts, Partition in Fructus Juglandis 3 parts, Rhizoma Dioscoreae 15 parts, 36 parts of Radix Glycyrrhizae, Lumbrukinase 15 parts.

The preparation method of aforementioned pharmaceutical compositions is:

(1) said components is weighed by weight;

(2) Cornu Cervi Pantotrichum and Radix Ginseng grind into powder respectively;

(3) Hirudo, Penis et testis cervi, Gecko, Gecko hero testis, Hippocampus, adding 4 ~ 6 times of weight concentrations of above-mentioned each component weight is the ethanol of 70 ~ 80%, heating and refluxing extraction 2 ~ 3 times, each 2 ~ 5 hours, gradation filtered, merging filtrate, concentration, reclaims ethanol, obtains concentrated solution A; Standby;

(4) Herba Epimedii, Herba Cistanches, Herba Cynomorii, Eurycoma longifolia, Concha Ostreae, Radix Codonopsis, Partition in Fructus Juglandis, Rhizoma Dioscoreae and Radix Glycyrrhizae, add the water of above-mentioned 6 ~ 10 times of weight of each component weight, heating extraction 2 ~ 3 times, each 1 ~ 2 hour, gradation filtered, merging filtrate, add concentrated solution A, be condensed into thick paste, add Pilose Antler, Radix Ginseng powder, Lumbrukinase and appropriate amount of starch, dry, pulverizing, get dry extract powder;

(5) take dried cream powder and add starch slurry, magnesium stearate and microcrystalline Cellulose, mixing, make granule, load capsule, obtain capsule.

Two, clinical practice

1, the selection of case:

Select impotence patient, through 120 example clinical observations.

(1) inclusive criteria:

A. there are spouse male, 48 years old mean age at the age between 30-60 year.

B. tcm diagnosis impotence patient is standard: during between twenty and fifty man's sexual intercourse, owing to penis can not erect effectively, and causes more than the 75% of sexual intercourse plan and can not carry out, namely diagnosable for sexual impotence.

C. without organic disease.

C. can partner treatment, the patient of further consultation on time.

(2) exclusion standard

A. the age is below 30 years old or more than 60 years old person.

B. the organic impotence patient made a definite diagnosis.

C. severe primary disease and spirit, the psychotics such as cardiovascular, liver, kidney and hemopoietic system it are associated with.

D. allergic constitution or to multi-medicament allergy sufferers.

E. not by regulation medication or therapy discontinued, it is impossible to judge curative effect or data is not congruent affects the treatment or safety judgement person.

2, clinical trial:

(1) therapeutic scheme:

A. treatment group: by above-mentioned embodiment 1 ~ 3 sample prepared, for clinical trial. Oral, one time 2,3 times on the one. The course for the treatment of: medication 45 days.

B. matched group: NANBAO JIAONANG (commercially available). Oral, one time 3,2 times on the one. The course for the treatment of: medication 45 days.

(2) efficacy determination:

A. effective: erection > 90 after treatment, more than the 50% of sexual intercourse chance can success.

B. effective: after treatment, erection makes moderate progress, more than the 25% of sexual intercourse chance can success.

C. invalid: before and after medication, indices is all without improving.

(3) result of the test:

For treating 120 example outpatients. By above-mentioned embodiment 1, embodiment 4 and the NANBAO JIAONANG prepared, it is respectively used to patient: treatment group: 90 examples (take each 30 examples of embodiment 1 ~ 3), matched group: 30 examples. During clinical trial, withdraw other medicines and health nutrient. The results detailed in following table:

Group	Effective	Effectively	Invalid	Effective percentage
					Embodiment 1	14	13	3	90.0%
Embodiment 2	13	12	5	83.3%
					Embodiment 3	13	13	4	86.7%
Matched group	12	11	7	76.6%

Result shows: embodiment 1 best results, and effective percentage reaches 90%, is better than matched group; The effective percentage of embodiment 2 and 3 reaches more than 80%, also superior to matched group. Patient is after treatment, it is common to reaction can improve the symptom of myasthenia of limbs, impotence and premature ejaculation.

Claims (5)

1. the pharmaceutical composition of a kidney invigorating and YANG supporting, it is characterised in that it is mainly made up by weight ratio of following components:

Hirudo 5 ~ 20 parts, Herba Epimedii 80 ~ 110, Herba Cistanches 15 ~ 28 parts, Penis et testis cervi 20 ~ 30 parts, 8 ~ 12 parts of Cornu Cervi Pantotrichum, Gecko 18 ~ 28 parts, Gecko hero testis 2 ~ 6 parts, Radix Ginseng 15 ~ 30 parts, Hippocampus 15 ~ 28 parts, Herba Cynomorii 12 ~ 25 parts, Eurycoma longifolia 5 ~ 12 parts, Concha Ostreae 15 ~ 30 parts, Radix Codonopsis 30 ~ 40 parts, Partition in Fructus Juglandis 1 ~ 3 part, Rhizoma Dioscoreae 10 ~ 15 parts, 22 ~ 36 parts of Radix Glycyrrhizae, Lumbrukinase 10 ~ 15 parts.

2. the pharmaceutical composition of kidney invigorating and YANG supporting according to claim 6, it is characterised in that it is mainly made up by weight ratio of following components:

Hirudo 12 parts, Herba Epimedii 105, Herba Cistanches 22 parts, Penis et testis cervi 25 parts, 10 parts of Cornu Cervi Pantotrichum, Gecko 23 parts, Gecko hero testis 4 parts, Radix Ginseng 23 parts, Hippocampus 23 parts, Herba Cynomorii 19 parts, Eurycoma longifolia 8 parts, Concha Ostreae 24 parts, Radix Codonopsis 35 parts, Partition in Fructus Juglandis 2 parts, Rhizoma Dioscoreae 13 parts, 31 parts of Radix Glycyrrhizae, Lumbrukinase 13 parts.

3. the pharmaceutical composition of kidney invigorating and YANG supporting according to claim 1 and 2, it is characterised in that:

Described pharmaceutical composition adds customary adjuvant by practice of pharmacy and makes any dosage form of clinical acceptance.

4. the pharmaceutical composition of kidney invigorating and YANG supporting according to claim 3, it is characterised in that:

Described dosage form is capsule.

5. the preparation method of the pharmaceutical composition of kidney invigorating and YANG supporting according to claim 1, it is characterised in that comprise the following steps:

(1) following component is weighed by weight: Hirudo 5 ~ 20 parts, Herba Epimedii 80 ~ 110, Herba Cistanches 15 ~ 28 parts, Penis et testis cervi 20 ~ 30 parts, 8 ~ 12 parts of Cornu Cervi Pantotrichum, Gecko 18 ~ 28 parts, Gecko hero testis 2 ~ 6 parts, Radix Ginseng 15 ~ 30 parts, Hippocampus 15 ~ 28 parts, Herba Cynomorii 12 ~ 25 parts, Eurycoma longifolia 5 ~ 12 parts, Concha Ostreae 15 ~ 30 parts, Radix Codonopsis 30 ~ 40 parts, Partition in Fructus Juglandis 1 ~ 3 part, Rhizoma Dioscoreae 10 ~ 15 parts, 22 ~ 36 parts of Radix Glycyrrhizae, Lumbrukinase 10 ~ 15 parts;

(2) Cornu Cervi Pantotrichum and Radix Ginseng grind into powder respectively;

(3) Hirudo, Penis et testis cervi, Gecko, Gecko hero testis, Hippocampus, adding 4 ~ 6 times of weight concentrations of above-mentioned each component weight is the ethanol of 70 ~ 80%, heating and refluxing extraction 2 ~ 3 times, each 2 ~ 5 hours, gradation filtered, merging filtrate, concentration, reclaims ethanol, obtains concentrated solution A; Standby;

(4) Herba Epimedii, Herba Cistanches, Herba Cynomorii, Eurycoma longifolia, Concha Ostreae, Radix Codonopsis, Partition in Fructus Juglandis, Rhizoma Dioscoreae and Radix Glycyrrhizae, add the water of above-mentioned 6 ~ 10 times of weight of each component weight, heating extraction 2 ~ 3 times, each 1 ~ 2 hour, gradation filtered, merging filtrate, add concentrated solution A, be condensed into thick paste, add Pilose Antler, Radix Ginseng powder, Lumbrukinase and appropriate amount of starch, dry, pulverizing, get dry extract powder;

(5) take dried cream powder and add starch slurry, magnesium stearate and microcrystalline Cellulose, mixing, make granule, load capsule, obtain capsule.