CN105641424A - Postoperative tumor patient side-effect-resistant granules - Google Patents

Abstract

The invention discloses postoperative tumor patient side-effect-resistant granules. The postoperative tumor patient side-effect-resistant granules are mainly prepared from, by weight, 15 parts of Radix Astragali, 10 parts of Rhizoma Atractylodis Macrocephalae (stir-fried with bran), 4 parts of Radix Paeoniae Alba, 9 parts of Radix Salviae Miltiorrhizae, 8 parts of Cortex Magnoliae Officinalis, 4 parts of Radix Et Rhizoma Rhei, 8 parts of Colla Corii Asini, 5 parts of Indigo Naturalis, 11 parts of Rhizoma Anemarrhenae, 6 parts of Rhizoma Cyperi (processed with vinegar), 10 parts of Rhizoma Polygonati Odorati, 9 parts of costus root, 6 parts of Herba Eupatorii, 5 parts of Fructus Gardeniae (stir-fried) and 8 parts of Rhizome Pinelliae Preparata. The postoperative tumor patient side-effect-resistant granules are selected from traditional Chinese medicinal materials, free from any toxic or side effect, easily available to raw materials and low in medicinal material cost and cannot cause burden to patients.

Description

The anti-side reaction granule of postoperative tumor patient

Technical field

The present invention relates to traditional Chinese medicine field, particularly relate to the anti-side reaction medicament of a kind of postoperative tumor patient and preparation method.

Background technology

Chemotherapy is current tumor, a kind of therapeutic modality that especially malignant tumor patient is the most widely used. Its principle is in that: utilizes chemicals to kill tumor cell, suppresses the growth and breeding of tumor cell and promote the differentiation of tumor cell. Radiotherapy, i.e. radiation treatment, be one of big treatment means of cancer three. It is by the roentgenization tumor of various different-energies, to suppress and to kill a kind of Therapeutic Method of cancerous cell. Radiotherapy chemotherapy can be used alone, it is also possible to partner treatment, and as a part for Comprehensive Treatment, Radiotherapy chemotherapy can improve the cure rate of tumor. But Radiotherapy chemotherapy belongs to the scope of " sending an expedition against ", often occur attacking the situation that evil wound is positive, Radiotherapy chemotherapy treatment tumor is while killing tumor cell, also normal cell and immunity (opposing) cell are together killed, so being the Therapeutic Method of a kind of " destruction of all people good and bad alike ", therefore Radiotherapy chemotherapy over the course for the treatment of more there are some more serious toxicities of ratio, and harm is very big.

The side reaction of Radiotherapy chemotherapy shows themselves in that

1. health is weak: patient there will be health fatigue and weak, cold perspiration, drowsiness malaise symptoms such as grade after accepting Radiotherapy chemotherapy.

2. immunologic function degression: great majority have the chemotherapeutics of antitumor action that the immunologic function of patient is had inhibitory action,

The immunologic function degression of patient is caused after chemotherapy.

3. gastricism: a lot of chemotherapeutics cause a series of symptom by the mucosa in stimulating gastrointestinal road, such as appetite decline, dietary amount minimizing, Nausea and vomiting, abdominal distention, stomachache, diarrhoea or constipation etc.

4. nervous system toxin: mainly after accepting chemotherapy, peripheral terminals nerve is produced detrimental effect, the symptoms such as patient may occur in which acroanesthesia, and acra is insensitive by chemotherapeutics.

5. skin abnormality: dry skin shows as skin pruritus, pigmentation and decortication, can produce permanent light brown speckle. Moist cutaneous manifestations is irradiated site eczema, blister, can cause erosion, ulceration time serious.

Malignant tumor belongs to the category of the traditional Chinese medical science " amassing ", " asthenia ", there is the performance of vital QI being weakened and pathogen being violent. And due to being continuous of the course of disease, the phenomenon of " the kidney usually involved in chronic disease " can be caused. After accepting Radiotherapy chemotherapy, it is weakened body resistance, and disease becomes apparent from, and causes because vigour is impaired further: lethargy, malaise, dysphoria with feverish sensation in the chest palms and soles, few lazy language of speech etc. Hindering and then feel sick indigestion and loss of appetite in stomach, hinder in kidney then dizziness and tinnitus, dedentition loss of hairs, soreness of waist foot is soft, hinders in the heart then shortness of breath and palpitation.

Publication number is CN101549154A(application number 200910031557.0) Chinese patent literature disclose a kind of by name " a kind of radioprotective and alleviate the nutritional solution of radiotherapy side effect ", this nutritional solution is added carotene, chitosan, vitamin C, vitamin E etc. by normal saline and makes. Application publication number is CN103446206A(application number 201210184710.5) Chinese patent literature disclose a kind of by name " improving compositions and the application of toxicity caused by Chemotherapy in Malignant Carcinoma Patients ", said composition is by Ganoderma 5��200 parts, Radix Panacis Quinquefolii or Radix Ginseng 5��150 parts, fermented Cordyceps powder 1��90 part and/or Cordyceps 1��120 part, or by above-mentioned raw materials water and/or what alcohol extract formed as active ingredient. Publication number is CN1357354A(application number 01114965.5) Chinese patent literature disclose a kind of by name " medicine for the treatment of concurrent chemoradiotherapy of malignant tumor side reaction and preparation method thereof ", it is made up of Radix Codonopsis, the Radix Astragali, Poria, the Rhizoma Atractylodis Macrocephalae, Fructus Ligustri Lucidi, Fructus Lycii, burnt short, bristly hair or beard, Radix Glycyrrhizae.

In a word, Chinese medicine achieves certain achievement in treatment Radiotherapy chemotherapy toxicity, but there is also some problems: existing oncotherapy preparation can not solve the toxicity of chemotherapy on human body well, to such an extent as to a lot of tumor patient is in heaven in the toxicity of Radiotherapy chemotherapy over the course for the treatment of, therefore need to be improved further perfect.

Summary of the invention

For the deficiencies in the prior art, an object of the present invention is in that to provide the anti-side reaction medicament of a kind of postoperative tumor patient, has easy operation, feature evident in efficacy, and it adopts Chinese crude drug relatively conventional in the localities as raw material, with low cost.

The technical scheme is that

The anti-side reaction medicament of postoperative tumor patient, takes off the primary raw material stating weight proportion and is prepared from: Radix Astragali 20-30 part, the Rhizoma Atractylodis Macrocephalae (parched with bran) 6-15 part, Radix Paeoniae Alba 2-6 part, Radix Salviae Miltiorrhizae 6-12 part, Cortex Magnoliae Officinalis 4-12 part, Radix Et Rhizoma Rhei 3-6 part, Colla Corii Asini 5-12 part, Indigo Naturalis 3-6 part, Rhizoma Anemarrhenae 7-15 part, Rhizoma Cyperi (vinegar) 4-8 part, Rhizoma Polygonati Odorati 6-15 part, Radix Aucklandiae (Radix Vladimiriae) 6-12 part, Herba Eupatorii 3-9 part, Fructus Gardeniae (stir-fry) 3-6 part, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 4-12 part.

The anti-side reaction medicament of postoperative tumor patient, it is preferred that scheme is, takes off the primary raw material stating weight proportion and is prepared from: Radix Astragali 13-16 part, the Rhizoma Atractylodis Macrocephalae (parched with bran) 8-12 part, Radix Paeoniae Alba 3-5 part, Radix Salviae Miltiorrhizae 8-10 part, Cortex Magnoliae Officinalis 6-10 part, Radix Et Rhizoma Rhei 3-5 part, Colla Corii Asini 7-10 part, Indigo Naturalis 4-6 part, Rhizoma Anemarrhenae 9-13 part, Rhizoma Cyperi (vinegar) 5-7 part, Rhizoma Polygonati Odorati 8-12 part, Radix Aucklandiae (Radix Vladimiriae) 8-10 part, Herba Eupatorii 5-7 part, Fructus Gardeniae (stir-fry) 4-6 part, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 7-9 part.

The anti-side reaction medicament of postoperative tumor patient, it is more preferable to scheme be take off the primary raw material stating weight proportion and be prepared from: the Radix Astragali 15 parts, the Rhizoma Atractylodis Macrocephalae (parched with bran) 10 parts, the Radix Paeoniae Alba 4 parts, Radix Salviae Miltiorrhizae 9 parts, Cortex Magnoliae Officinalis 8 parts, Radix Et Rhizoma Rhei 4 parts, 8 parts of Colla Corii Asini, Indigo Naturalis 5 parts, the Rhizoma Anemarrhenae 11 parts, Rhizoma Cyperi (vinegar) 6 parts, Rhizoma Polygonati Odorati 10 parts, Radix Aucklandiae (Radix Vladimiriae) 9 parts, Herba Eupatorii 6 parts, Fructus Gardeniae (stir-fry) 5 parts, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 8 parts.

Present invention also offers and above-mentioned postoperative tumor patient anti-side reaction medicament is made pharmaceutically acceptable powder, water preparation, unguentum, granule, tablet or capsule.

The preparation method of described powder is:

(1) Radix Et Rhizoma Rhei, Indigo Naturalis, Colla Corii Asini are respectively crushed into fine powder, cross 60-120 mesh sieve and (preferably, cross 85-115 mesh sieve; More preferably, 105 mesh sieves are crossed);

(2) Radix Astragali, the Rhizoma Atractylodis Macrocephalae (parched with bran), the Radix Paeoniae Alba, Radix Salviae Miltiorrhizae, Cortex Magnoliae Officinalis, the Rhizoma Anemarrhenae, Rhizoma Cyperi (vinegar), Rhizoma Polygonati Odorati, Radix Aucklandiae (Radix Vladimiriae), Herba Eupatorii, Fructus Gardeniae (stir-fry) and Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) co-grinding are crossed 85-135 mesh sieve and (preferably, crosses 100-120 mesh sieve; More preferably, 110 mesh sieves are crossed);

(3) step (1) and (2) gained are mixed.

The preparation method of described water preparation is:

(1) Radix Et Rhizoma Rhei, Indigo Naturalis, Colla Corii Asini are respectively crushed into fine powder, cross 60-120 mesh sieve and (preferably, cross 85-115 mesh sieve; More preferably, 105 mesh sieves are crossed);

(2) Radix Astragali, the Rhizoma Atractylodis Macrocephalae (parched with bran), the Radix Paeoniae Alba, Radix Salviae Miltiorrhizae, Cortex Magnoliae Officinalis, the Rhizoma Anemarrhenae, Rhizoma Cyperi (vinegar), Rhizoma Polygonati Odorati, Radix Aucklandiae (Radix Vladimiriae), Herba Eupatorii, Fructus Gardeniae (stir-fry) and Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) are placed in marmite, add water (water consumption be crude drug gross weight 2.5-4.5 times (preferred, 3-4 times; More preferably, 3.5 times)) decoct 2 times, 1.2-2.4 hour first time (preferred, 1.5-2.0 hour; More preferably, 1.8 hours), second time 0.8-1.2 hour (preferred 0.9-1.1 hour; More preferably, 1.0 hours), filtrate merges, and lets cool;

(3) Radix Et Rhizoma Rhei after step (1) pulverizing, Indigo Naturalis and Colla Corii Asini are added step (2) gained medicinal liquid, sterile packaged.

The preparation method of described unguentum is:

(1) Radix Et Rhizoma Rhei, Indigo Naturalis, Colla Corii Asini are respectively crushed into fine powder, cross 60-120 mesh sieve (preferred, cross 85-115 mesh sieve, it is more preferable to, cross 105 mesh sieves);

(2) Radix Astragali, the Rhizoma Atractylodis Macrocephalae (parched with bran), the Radix Paeoniae Alba, Radix Salviae Miltiorrhizae, Cortex Magnoliae Officinalis, the Rhizoma Anemarrhenae, Rhizoma Cyperi (vinegar), Rhizoma Polygonati Odorati, Radix Aucklandiae (Radix Vladimiriae), Herba Eupatorii, Fructus Gardeniae (stir-fry) and Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) are placed in marmite, add water (water consumption be crude drug gross weight 2.5-4.5 times (preferred, 3-4 times; More preferably, 3.5 times)) decoct 2 times, 1.2-2.4 hour first time (preferred, 1.5-2.0 hour; More preferably, 1.8 hours), second time 0.8-1.2 hour (preferred 0.9-1.1 hour; More preferably, 1.0 hours), filtrate merges, and filters, concentrate relative density is 1.36-1.38(48 DEG C) clear paste;

(3) Radix Et Rhizoma Rhei after step (1) pulverizing, Indigo Naturalis and Colla Corii Asini are added step (2) gained clear paste, sterile packaged.

The preparation method of described granule is:

(1) Radix Et Rhizoma Rhei, Indigo Naturalis, Colla Corii Asini are respectively crushed into fine powder, cross 60-120 mesh sieve and (preferably, cross 85-115 mesh sieve; More preferably, 105 mesh sieves are crossed);

(2) Radix Astragali, the Rhizoma Atractylodis Macrocephalae (parched with bran), the Radix Paeoniae Alba, Radix Salviae Miltiorrhizae, Cortex Magnoliae Officinalis, the Rhizoma Anemarrhenae, Rhizoma Cyperi (vinegar), Rhizoma Polygonati Odorati, Radix Aucklandiae (Radix Vladimiriae), Herba Eupatorii, Fructus Gardeniae (stir-fry) and Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) are placed in marmite, add water (water consumption be crude drug gross weight 2.5-4.5 times (preferred, 3-4 times; More preferably, 3.5 times)) decoct 2 times, 1.2-2.4 hour first time (preferred, 1.5-2.0 hour; More preferably, 1.8 hours), second time 0.8-1.2 hour (preferred 0.9-1.1 hour; More preferably, 1.0 hours), filtrate merges, and filters, concentrate relative density is 1.36-1.38(48 DEG C) clear paste;

(3) qinghuo reagent 0.8-1.2 part (preferably, 0.9-1.1 part; More preferably, 1.0 parts), sucrose 1.5-3.5 part (preferred, 2-3 part; 2.5 parts more preferably), and dextrin 0.8-1.2 part (preferred, 0.9-1.1 part; More preferably, 1.0 parts), add step (1) gained Radix Et Rhizoma Rhei, Indigo Naturalis and donkey-hide gelatin fine powder after mixing, mixing, make granule, dry, obtain granule.

The preparation method of described tablet is: by claim 5 gained medicament powder according to 0.3-0.5g/ sheet (preferably, 0.35-0.45g/ sheet; More preferably, 0.4g/ sheet) metering, the tablet dosage form of circle or other shapes it is pressed into according to the preparation for processing of tablet.

The preparation method of described capsule is: by claim 5 gained medicament powder according to 0.4-0.6g/ grain (preferably, 0.45-0.55g/ grain; More preferably, 0.5g/ grain) metering, it is processed into capsule shape dosage form according to the preparation for processing of capsule.

The pharmacology of the present invention main raw material of Chinese medicine used is as follows:

The Radix Astragali: nature and flavor: sweet in the mouth, temperature. Gui Jing: return lung, spleen channel. Effect: benefiting qi and raising yang, strengthening superficial resistance to stop perspiration, inducing diuresis to remove edema, promoting pus discharge and tissue regeneration strengthening. Curing mainly: the card of all Qi and blood deficiencies, such as diarrhea due to hypofunction of the spleen, cough due to deficiency of the lung, proctoptosis, uterine prolapse, spontaneous perspiration, night sweat, edema, arthralgia due to stagnation of blood, carbuncle difficulty is burst or is burst for a long time and do not hold back.

The Rhizoma Atractylodis Macrocephalae (parched with bran): nature and flavor: bitter in the mouth, sweet, temperature. Gui Jing: return spleen, stomach warp. Effect: invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive. Cure mainly: deficiency-weakness of spleen-QI weak, lack of appetite abdominal distention, constipation of having loose bowels, the dysuria of fluid-retention stagnating in the interior, edema, dizziness due to fluid-retention, cold-damp numbness, general pain, spontaneous sweating due to deficiency of QI, frequent fetal movement.

The Radix Paeoniae Alba: nature and flavor: bitter in the mouth, acid, it is slightly cold. Gui Jing: return liver, spleen channel. Effect: joint venture of nourishing blood, relieving spasm to stop pain, yin fluid astringing suppressing the hyperactive liver. Curing mainly: blood deficiency cold and heat, epigastric pain, hypochondriac pain, limb spasm pain, dysmenorrhea, menoxenia, metrorrhagia, spontaneous perspiration, night sweat, dysentery is had loose bowels, dizziness of having a headache.

Radix Salviae Miltiorrhizae: nature and flavor: bitter in the mouth, is slightly cold. Gui Jing: GUIXIN, pericardium, Liver Channel. Effect: blood circulation promoting and blood stasis dispelling, menstruction regulating and pain relieving, relieving restlessness is calmed the nerves, removing heat from blood eliminating carbuncle. Curing mainly: menoxenia, dysmenorrhea, amenorrhea, stomachache of being retarded by silt puerperal, trusted subordinate's pain, abdominal mass is gathered, and pyretic arthralgia swells and ache, traumatic injury, and heat enters nutrient blood, dysphoria, vexed insomnia, ulcerative carbuncle toxic swelling.

Cortex Magnoliae Officinalis: nature and flavor: bitter in the mouth, pungent, warm in nature. Gui Jing: return spleen, stomach large intestine channel. Effect: circulation of qi promoting removing food stagnancy, dampness acaricide, lowering the adverse QI to relieve asthma. Curing mainly: stagnation of QI due to dyspepsia, abdominal distention constipation, retention of dampness in middle-JIAO, gastral cavity painful abdominal mass is vomited and diarrhoea, and expectorant stops up QI rising in reverse order, breathes with cough.

Radix Et Rhizoma Rhei: nature and flavor: bitter in the mouth, cold. Gui Jing: stomach, large intestine, liver, spleen channel. Effect: attack stagnant, clearing away damp-heat, pathogenic fire purging, removing heat from blood, blood stasis dispelling, removing toxic substances. Cure mainly: solid cubic content constipation, the accumulation of heat feeling of stuffiness in chest; Damp-heat dysentery, jaundice, gonorrhea, edema abdominal distention, dysuria; Conjunctival congestion, laryngopharynx swelling and pain, aphtha of the mouth and tongue, gastropyretic vomiting, spit blood, spitting of blood, epistaxis, have blood in stool, hematuria; Blood-retention, amenorrhea, stomachache of being retarded by silt puerperal, abdominal mass is gathered, traumatic injury, pyretic toxicity carbuncle and ulcer, erysipelas, scalds.

Colla Corii Asini: nature and flavor: sweet in the mouth is flat. Gui Jing: return liver, lung, kidney channel. Effect: tonifying blood and arresting bleeding, nourishing YIN and moistening the lung. Cure mainly: dizziness due to deficiency of blood, spit blood, epistaxis, to have blood in stool, dysentery, gestation hemorrhage, metrorrhagia, fidgets due to deficiency is had a sleepless night, deficiency of the lung cough caused by dryness.

Indigo Naturalis: nature and flavor: salty in the mouth, cold. Gui Jing: return liver, lung, stomach warp. Effect: heat clearing away, removing heat from blood, removing toxic substances. Curing mainly: temperature poison macule, spit blood, epistaxis, spitting of blood, pediatric epilepsy scared, liver-fire invading the lung is coughed, laryngopharynx swelling and pain, erysipelas, mumps, and skin ulcer swells, snake bite and insect sting.

The Rhizoma Anemarrhenae: nature and flavor: bitter in the mouth, cold. Gui Jing: return lung, stomach, kidney channel. Effect: clearing away heat-fire, nourshing Yin and drynsessmoistening prescription. Cure mainly: the high hot excessive thirst of epidemic febrile disease, cough due to lung-heat, osteopyrexia and fever, seminal emission, night sweat, restlessness of asrhenia type and insomnia, quench one's thirst.

Rhizoma Cyperi (vinegar): nature and flavor: acrid in the mouth, hardship sweet, micro-, flat.Gui Jing: return liver, tri-jiao channel. Effect: resolving depression of regulating the flow of vital energy, regulating menstruation, antiabortive. Cure mainly: distending pain over the hypochondrium, distending pain of the breast, hernia pain, menoxenia, gastral cavity abdomen feeling of fullness pain, belch acid regurgitation, vomiting and nausea, abdominal pain during menstruation, bleeding not during menses, frequent fetal movement.

Rhizoma Polygonati Odorati: nature and flavor: sweet in the mouth, flat. Gui Jing: attach to the lung and stomach meridians. Effect: nourishing YIN and moistening the lung, nourishing the stomach to promote the production of body fluid. Curing mainly: cough caused by dryness, chronic cough, calentura the moon is hindered, and dry throat and mouth is quenched one's thirst, deficiency of YIN diseases caused by exogenous pathogenic factor, dizzy dizziness, muscle arteries and veins spasm and pain.

Radix Aucklandiae (Radix Vladimiriae): nature and flavor: acrid in the mouth, hardship, temperature. Gui Jing: return lung, liver, spleen channel. Effect: promoting the circulation of QI to relieve pain, warming middle-JIAO for easing the stomach. Cure mainly: chest and abdomen swelling and pain, vomiting, have loose bowels, dysentery tenesmus.

Herba Eupatorii: nature and flavor: acrid in the mouth, flat. Gui Jing: return spleen, stomach warp. Effect: expelling summer-heat and damp, be amusing and in. Cure mainly: heat-damp in summer or hygropyrexia from the beginning of, generate heat nose heave, abdominal distention uncomfortable in chest, gastral cavity painful abdominal mass is not hungry, nausea and vomiting, sweet greasy in mouth, quenches one's thirst.

Fructus Gardeniae (stir-fry): nature and flavor: bitter in the mouth, cold. Gui Jing: GUIXIN, liver, lung, stomach, tri-jiao channel. Effect: pathogenic fire purging relieving restlessness, clearing away heat-damp and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body. Cure mainly: calentura is vexed, liver-fire conjunctival congestion, headache, jaundice due to damp-heat, stranguria, spit blood, epistaxis, dysentery, hematuria, aphtha of the mouth and tongue, sore swollen toxin, sprain and swell and ache.

Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens): nature and flavor: acrid in the mouth, temperature. Gui Jing: return spleen, stomach, lung meridian. Effect: stopping nausea and vomiting by lowering the adverse flow of QI. Cure mainly: vomiting regurgitation, breast gastral cavity painful abdominal mass is vexed, globus hystericus.

Medicament of the present invention based on traditional Chinese medical herbal treatment Radiotherapy chemotherapy side reaction principle, is make on the basis of lot of documents, pharmacology work and clinical trial have studied. Selected materials of the present invention is Chinese medicine material, without any side effects, and this medicament is fully according to the body and mind feature of Chinese medicine principle and tumor patient, and the side reaction that Radiotherapy chemotherapy is caused has good therapeutic effect.

Detailed description of the invention

Describe technical scheme in detail below in conjunction with embodiment and experimental example, but protection domain is not limited to this.

The anti-side reaction medicament of the postoperative tumor patient of embodiment 1, takes off the primary raw material stating weight proportion and is prepared from (every part of 10g): the Radix Astragali 15 parts, the Rhizoma Atractylodis Macrocephalae (parched with bran) 10 parts, the Radix Paeoniae Alba 4 parts, Radix Salviae Miltiorrhizae 9 parts, Cortex Magnoliae Officinalis 8 parts, Radix Et Rhizoma Rhei 4 parts, 8 parts of Colla Corii Asini, Indigo Naturalis 5 parts, the Rhizoma Anemarrhenae 11 parts, Rhizoma Cyperi (vinegar) 6 parts, Rhizoma Polygonati Odorati 10 parts, Radix Aucklandiae (Radix Vladimiriae) 9 parts, Herba Eupatorii 6 parts, Fructus Gardeniae (stir-fry) 5 parts, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 8 parts.

The preparation method of the anti-side reaction medicament powder of above-mentioned postoperative tumor patient is:

(1) Radix Et Rhizoma Rhei, Indigo Naturalis, Colla Corii Asini are respectively crushed into fine powder, cross 105 mesh sieves;

(2) Radix Astragali, the Rhizoma Atractylodis Macrocephalae (parched with bran), the Radix Paeoniae Alba, Radix Salviae Miltiorrhizae, Cortex Magnoliae Officinalis, the Rhizoma Anemarrhenae, Rhizoma Cyperi (vinegar), Rhizoma Polygonati Odorati, Radix Aucklandiae (Radix Vladimiriae), Herba Eupatorii, Fructus Gardeniae (stir-fry) and Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) co-grinding are crossed 110 mesh sieves;

(3) step (1) and (2) gained are mixed.

Powder instructions of taking of the present invention: powder divides 5g/ bag, adopts every day 2-3 time, each one bag, with warm boiled water, 7 days courses for the treatment of.

Model case one Jiang XX, the age: 45 years old, sex: man. In August, 2009 makes carcinoma of gastric cardia Palliative Hepatectomy in hospital, the postoperative chemotherapy that always accepts is to alleviate slight illness, chemotherapy causes following uncomfortable reaction: appetite is low, malaise with nausea and vomiting phenomenon, what lassitude, does and all has no spirit, and patient once took the medicine of anti-chemotherapy side effect, without obvious therapeutic effect, have a strong impact on orthobiosis. Take the anti-side reaction medicament of the postoperative tumor patient of the present embodiment gained, adopt every day 3 times, each one bag, with warm boiled water, 7 days courses for the treatment of.Taking 21 days, patient's appetite strengthens to some extent, and malaise symptoms is alleviated; Taking 2 months, patients ' vomiting phenomenon disappears, and spirit, muscle power are remarkably reinforced; Continuing to take two months, malaise symptoms is wholly absent, and patient's self-induction is fully recovered.

The anti-side reaction medicament of the postoperative tumor patient of embodiment 2, takes off the primary raw material stating weight proportion and is prepared from (every part of 20g): the Radix Astragali 15 parts, the Rhizoma Atractylodis Macrocephalae (parched with bran) 10 parts, the Radix Paeoniae Alba 4 parts, Radix Salviae Miltiorrhizae 9 parts, Cortex Magnoliae Officinalis 8 parts, Radix Et Rhizoma Rhei 4 parts, 8 parts of Colla Corii Asini, Indigo Naturalis 5 parts, the Rhizoma Anemarrhenae 11 parts, Rhizoma Cyperi (vinegar) 6 parts, Rhizoma Polygonati Odorati 10 parts, Radix Aucklandiae (Radix Vladimiriae) 9 parts, Herba Eupatorii 6 parts, Fructus Gardeniae (stir-fry) 5 parts, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 8 parts.

The preparation method of the anti-side reaction medicament unguentum of above-mentioned postoperative tumor patient is:

(1) Radix Et Rhizoma Rhei, Indigo Naturalis, Colla Corii Asini are respectively crushed into fine powder, cross 105 mesh sieves;

(2) Radix Astragali, the Rhizoma Atractylodis Macrocephalae (parched with bran), the Radix Paeoniae Alba, Radix Salviae Miltiorrhizae, Cortex Magnoliae Officinalis, the Rhizoma Anemarrhenae, Rhizoma Cyperi (vinegar), Rhizoma Polygonati Odorati, Radix Aucklandiae (Radix Vladimiriae), Herba Eupatorii, Fructus Gardeniae (stir-fry) and Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) are placed in marmite, add water 3.5 times of crude drug gross weight (water consumption be) decoct 2 times, 1.8 hours first times, second time 1.0 hours, filtrate merges, filter, concentrate relative density is 1.36-1.38(48 DEG C) clear paste;

(3) Radix Et Rhizoma Rhei after step (1) pulverizing, Indigo Naturalis and Colla Corii Asini are added step (2) gained clear paste, sterile packaged.

Unguentum instructions of taking of the present invention: unguentum adopts every day 2 times, each 8-10g, washes by water according to the ratio of 1:10 and takes, 7 days courses for the treatment of.

Model case two poplar XX, the age: 65 years old, sex: female. Primary hepatic carcinoma rupture in 2008, emergency case is cut open the belly, and excises cancer block, treats residual cancer by the method for chemotherapy afterwards, and patient's readme chemotherapy can cause some side reactions, mainly has: tired, insensitive, the lethargy of hypoimmunity, inappetence, acra etc. Take the anti-side reaction medicament unguentum of the postoperative tumor patient of the present embodiment gained, adopt every day 2 times, each 10g, wash by water according to the ratio of 1:10 and take, 7 days courses for the treatment of. Taking 15 days, patient mental's state takes a turn for the better, and appetite strengthens to some extent; Taking 1 month, immunity improves, and malaise symptoms fades away; Continuing to take 2 months, do not occur any discomfort when patient takes, the symptom that feels uneasy is wholly absent.

The anti-side reaction medicament of the postoperative tumor patient of embodiment 3, takes off the primary raw material stating weight proportion and is prepared from (every part of 30g): the Radix Astragali 15 parts, the Rhizoma Atractylodis Macrocephalae (parched with bran) 10 parts, the Radix Paeoniae Alba 4 parts, Radix Salviae Miltiorrhizae 9 parts, Cortex Magnoliae Officinalis 8 parts, Radix Et Rhizoma Rhei 4 parts, 8 parts of Colla Corii Asini, Indigo Naturalis 5 parts, the Rhizoma Anemarrhenae 11 parts, Rhizoma Cyperi (vinegar) 6 parts, Rhizoma Polygonati Odorati 10 parts, Radix Aucklandiae (Radix Vladimiriae) 9 parts, Herba Eupatorii 6 parts, Fructus Gardeniae (stir-fry) 5 parts, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 8 parts.

The preparation method of the anti-side reaction pharmacy particle agent of above-mentioned postoperative tumor patient is:

(1) Radix Et Rhizoma Rhei, Indigo Naturalis, Colla Corii Asini are respectively crushed into fine powder, cross 105 mesh sieves;

(2) Radix Astragali, the Rhizoma Atractylodis Macrocephalae (parched with bran), the Radix Paeoniae Alba, Radix Salviae Miltiorrhizae, Cortex Magnoliae Officinalis, the Rhizoma Anemarrhenae, Rhizoma Cyperi (vinegar), Rhizoma Polygonati Odorati, Radix Aucklandiae (Radix Vladimiriae), Herba Eupatorii, Fructus Gardeniae (stir-fry) and Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) are placed in marmite, add water 3.5 times of crude drug gross weight (water consumption be) decoct 2 times, 1.8 hours first times, second time 1.0 hours, filtrate merges, filter, concentrate relative density is 1.36-1.38(48 DEG C) clear paste;

(3) qinghuo reagent 1.0 parts, sucrose 2.5 parts, 1.0 parts of dextrin, add step (1) gained Radix Et Rhizoma Rhei, Indigo Naturalis and donkey-hide gelatin fine powder after mixing, mixing, make granule, dry, obtain granule.

Granule instructions of taking of the present invention: granule is divided 10g/ bag, every day 2-3 time, each one bag, with warm boiled water, 7 days courses for the treatment of.

Model case three king XX, the age: 70 years old, sex: man. Patient does stomach resecting operation, does chemotherapy afterwards always and treats, and there will be following malaise symptoms: lassitude after each chemotherapy of patient's readme, and without appetite, malaise, skin abnormality dries, drowsiness etc. Take the anti-side reaction pharmacy particle agent of the postoperative tumor patient of the present embodiment gained, adopt every day 3 times, each 1 one bags, with warm boiled water, 7 days courses for the treatment of. Taking 10 days, patient's appetite strengthens to some extent, and malaise symptoms improves gradually; Taking 1 month, patient's muscle power strengthens, and the mental status is clearly better; Continuing to take 2 months, malaise symptoms disappears.

The anti-side reaction medicament of the postoperative tumor patient of embodiment 4, takes off the primary raw material stating weight proportion and is prepared from (every part of 40g): the Radix Astragali 15 parts, the Rhizoma Atractylodis Macrocephalae (parched with bran) 10 parts, the Radix Paeoniae Alba 4 parts, Radix Salviae Miltiorrhizae 9 parts, Cortex Magnoliae Officinalis 8 parts, Radix Et Rhizoma Rhei 4 parts, 8 parts of Colla Corii Asini, Indigo Naturalis 5 parts, the Rhizoma Anemarrhenae 11 parts, Rhizoma Cyperi (vinegar) 6 parts, Rhizoma Polygonati Odorati 10 parts, Radix Aucklandiae (Radix Vladimiriae) 9 parts, Herba Eupatorii 6 parts, Fructus Gardeniae (stir-fry) 5 parts, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 8 parts.

The preparation method of the anti-side reaction medicament tablet of above-mentioned postoperative tumor patient is:

(1) Radix Et Rhizoma Rhei, Indigo Naturalis, Colla Corii Asini are respectively crushed into fine powder, cross 105 mesh sieves;

(2) Radix Astragali, the Rhizoma Atractylodis Macrocephalae (parched with bran), the Radix Paeoniae Alba, Radix Salviae Miltiorrhizae, Cortex Magnoliae Officinalis, the Rhizoma Anemarrhenae, Rhizoma Cyperi (vinegar), Rhizoma Polygonati Odorati, Radix Aucklandiae (Radix Vladimiriae), Herba Eupatorii, Fructus Gardeniae (stir-fry) and Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) co-grinding are crossed 110 mesh sieves;

(3) step (1) and (2) gained are mixed to obtain powder;

(4) step (3) gained powder is measured according to 0.4g/ sheet, be pressed into the tablet dosage form of circle or other shapes according to the preparation for processing of tablet.

Tablets instructions of taking: tablet adopts every day 3 times, and each 5-8 sheet, with warm boiled water, 7 days courses for the treatment of.

Model case four Wu XX, the age: 63 years old, sex: man. Postoperative 10 years of patient bottom right malignant tumor of jaw, in March, 2007 is at hospital diagnosis, middle lobe of right lung has a solitary sick point, patient coughs, chest pain, diagnoses as lung cancer metastasis, undergos surgery afterwards, postoperative alleviate slight illness by chemicotherapy, but chemicotherapy causes a series of uncomfortable reaction: acroanesthesia, general fatigue are unable, appetite is low, drowsiness etc. Take the anti-side reaction medicament tablet of the postoperative tumor patient of the present embodiment gained, adopt every day 3 times, each 8, with warm boiled water, 7 days courses for the treatment of. Taking 7 days, patient's malaise symptoms alleviates to some extent, and food of receiving is gradually many; Taking 2 months, malaise symptoms fades away, and spirit, muscle power are remarkably reinforced; Continuing to take two months, patient's self-induction is fully recovered.

The anti-side reaction medicament of the postoperative tumor patient of embodiment 5, takes off the primary raw material stating weight proportion and is prepared from (every part of 50g): the Radix Astragali 15 parts, the Rhizoma Atractylodis Macrocephalae (parched with bran) 10 parts, the Radix Paeoniae Alba 4 parts, Radix Salviae Miltiorrhizae 9 parts, Cortex Magnoliae Officinalis 8 parts, Radix Et Rhizoma Rhei 4 parts, 8 parts of Colla Corii Asini, Indigo Naturalis 5 parts, the Rhizoma Anemarrhenae 11 parts, Rhizoma Cyperi (vinegar) 6 parts, Rhizoma Polygonati Odorati 10 parts, Radix Aucklandiae (Radix Vladimiriae) 9 parts, Herba Eupatorii 6 parts, Fructus Gardeniae (stir-fry) 5 parts, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 8 parts.

The preparation method of the anti-side reaction drug capsule agent of above-mentioned postoperative tumor patient is:

(1) Radix Et Rhizoma Rhei, Indigo Naturalis, Colla Corii Asini are respectively crushed into fine powder, cross 105 mesh sieves;

(2) Radix Astragali, the Rhizoma Atractylodis Macrocephalae (parched with bran), the Radix Paeoniae Alba, Radix Salviae Miltiorrhizae, Cortex Magnoliae Officinalis, the Rhizoma Anemarrhenae, Rhizoma Cyperi (vinegar), Rhizoma Polygonati Odorati, Radix Aucklandiae (Radix Vladimiriae), Herba Eupatorii, Fructus Gardeniae (stir-fry) and Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) co-grinding are crossed 110 mesh sieves;

(3) step (1) and (2) gained are mixed to obtain powder;

(4) step (3) gained powder is measured according to 0.5g/ grain, be processed into capsule shape dosage form according to the preparation for processing of capsule.

Capsule instructions of taking of the present invention: capsule adopts every day 3 times, and each 6-10 grain, with warm boiled water, 7 days courses for the treatment of.

Model case five side XX, the age: 49 years old, sex: female. In May, 2007 stomach discomfort, the swollen greatly thing of egg is had from touching epigastrium, gastroscopy pathology confirms malignant lymphoma of stomach, the postoperative chemicotherapy that accepts is to reduce slight illness, the malaise symptoms such as vomiting, inappetence, metal fatigue, hypoimmunity but chemicotherapy causes nausea, took the medicine of many anti-chemotherapy side effects, all without positive effect. Taking the anti-chemotherapy side effect medicament of the postoperative tumor patient of the present embodiment gained, adopt every day 3 times, each 10, take 14 days, patient's malaise symptoms alleviates, and appetite strengthens; Taking 1 month, patient's malaise symptoms fades away, and the mental status takes a turn for the better, and muscle power strengthens; Continuing to take 2 months, patient's self-induction is without malaise symptoms.

The anti-side reaction medicament of the postoperative tumor patient of embodiment 6, takes off the primary raw material stating weight proportion and is prepared from (every part of 60g): the Radix Astragali 15 parts, the Rhizoma Atractylodis Macrocephalae (parched with bran) 10 parts, the Radix Paeoniae Alba 4 parts, Radix Salviae Miltiorrhizae 9 parts, Cortex Magnoliae Officinalis 8 parts, Radix Et Rhizoma Rhei 4 parts, 8 parts of Colla Corii Asini, Indigo Naturalis 5 parts, the Rhizoma Anemarrhenae 11 parts, Rhizoma Cyperi (vinegar) 6 parts, Rhizoma Polygonati Odorati 10 parts, Radix Aucklandiae (Radix Vladimiriae) 9 parts, Herba Eupatorii 6 parts, Fructus Gardeniae (stir-fry) 5 parts, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 8 parts.

The preparation method of the anti-side reaction medicament water preparation of above-mentioned postoperative tumor patient is:

(1) Radix Et Rhizoma Rhei, Indigo Naturalis, Colla Corii Asini are respectively crushed into fine powder, cross 105 mesh sieves;

(2) Radix Astragali, the Rhizoma Atractylodis Macrocephalae (parched with bran), the Radix Paeoniae Alba, Radix Salviae Miltiorrhizae, Cortex Magnoliae Officinalis, the Rhizoma Anemarrhenae, Rhizoma Cyperi (vinegar), Rhizoma Polygonati Odorati, Radix Aucklandiae (Radix Vladimiriae), Herba Eupatorii, Fructus Gardeniae (stir-fry) and Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) are placed in marmite, add water 3.5 times of crude drug gross weight (water consumption be) decoct 2 times, 1.8 hours first times, second time 1.0 hours, filtrate merges, and lets cool;

(3) Radix Et Rhizoma Rhei after step (1) pulverizing, Indigo Naturalis and Colla Corii Asini are added step (2) gained medicinal liquid, sterile packaged.

Water preparation instructions of taking of the present invention: water preparation adopts every day 2 times (warm), each 300-500ml, 7 days courses for the treatment of.

The clinical practice of the anti-side reaction medicament water preparation of the test example 1 embodiment 6 postoperative tumor patient of gained: in May ,-2012 in July, 2008, screen 200 example patients in 8 hospitals, wherein women 96 example, male 104 example. Before test 2 weeks, this crowd carrying out Continuous Observation, record symptom and change, is randomly divided into two groups, experimental group and matched group, experimental group takes embodiment 6 products obtained therefrom, and matched group takes other medicine conventional medication such as () safe peace oral liquid, selenium Wei Kang. Using method is: taking twice (warm) every day, each 300m1-500m1(adjusts to some extent depending on concrete condition), 7 days courses for the treatment of. Curative effect situation criterion: cure: take one course for the treatment of of this product, malaise symptoms disappears, and energy and muscle power are remarkably reinforced; Effective: taking one course for the treatment of of this product, malaise symptoms alleviates or partial disappearance, energy and muscle power strengthen; Invalid: taking one course for the treatment of of this product, malaise symptoms is unchanged. Result is as shown in table 1.

Table 1: take the checking of embodiment 6 products obtained therefrom therapeutic effect

Therapeutic effect: cure 72 examples (72%), effective 26 examples (26%), invalid 2 examples (2%), total effective rate 98%.Effect is substantially better than matched group.

Take period self-induction symptom and muscle power change of spirit is as shown in table 2.

Table 2:

As shown in Table 2: take 10 days, the patient of more than 52% feels to take a turn for the better to some extent, and malaise symptoms improves; Taking 20 days, the patient of more than 73% feels to take a turn for the better to some extent, and malaise symptoms improves or disappears, and spirit, muscle power strengthen; Taking 30 days, more than 96% feel takes a turn for the better to some extent, and malaise symptoms improves or disappears, and spirit, muscle power strengthen, and some patients self-induction is fully recovered. Taking more than 30 days in experimental group, effective percentage is up to 94%, and matched group is only 75%.

Finally it should be noted that, embodiment is the detailed description of the invention that the present invention is optimum, it is not limited to the present invention, although the present invention being described in detail with reference to previous embodiment, for a person skilled in the art, technical scheme described in foregoing embodiments still can be modified by it, or wherein portion of techniques feature carries out equivalent replacement. All within the spirit and principles in the present invention, any amendment of making, equivalent replacement, improvement etc., should be included within protection scope of the present invention.

Claims (1)

1. the anti-side reaction granule of postoperative tumor patient, is characterized in that, takes off the primary raw material stating weight proportion and is prepared from: the Radix Astragali 15 parts, the Rhizoma Atractylodis Macrocephalae (parched with bran) 10 parts, the Radix Paeoniae Alba 4 parts, Radix Salviae Miltiorrhizae 9 parts, Cortex Magnoliae Officinalis 8 parts, Radix Et Rhizoma Rhei 4 parts, 8 parts of Colla Corii Asini, Indigo Naturalis 5 parts, the Rhizoma Anemarrhenae 11 parts, Rhizoma Cyperi (vinegar) 6 parts, Rhizoma Polygonati Odorati 10 parts, Radix Aucklandiae (Radix Vladimiriae) 9 parts, Herba Eupatorii 6 parts, Fructus Gardeniae (stir-fry) 5 parts, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 8 parts; Preparation method is:

(1) Radix Et Rhizoma Rhei, Indigo Naturalis, Colla Corii Asini are respectively crushed into fine powder, cross 105 mesh sieves;

(2) Radix Astragali, the Rhizoma Atractylodis Macrocephalae (parched with bran), the Radix Paeoniae Alba, Radix Salviae Miltiorrhizae, Cortex Magnoliae Officinalis, the Rhizoma Anemarrhenae, Rhizoma Cyperi (vinegar), Rhizoma Polygonati Odorati, Radix Aucklandiae (Radix Vladimiriae), Herba Eupatorii, Fructus Gardeniae (stir-fry) and Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) are placed in marmite, add water 3.5 times of crude drug gross weight (water consumption be) decoct 2 times, 1.8 hours first times, second time 1.0 hours, filtrate merges, filter, concentrate relative density is 1.36-1.38(48 DEG C) clear paste;

(3) qinghuo reagent 1.0 parts, sucrose 2.5 parts, 1.0 parts of dextrin, add step (1) gained Radix Et Rhizoma Rhei, Indigo Naturalis and donkey-hide gelatin fine powder after mixing, mixing, make granule, dry, obtain granule.