CN103920034B - Chinese medicine composition and the method for making of the side reaction of ameliorate tumor chemotherapy of patients - Google Patents

Chinese medicine composition and the method for making of the side reaction of ameliorate tumor chemotherapy of patients Download PDF

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CN103920034B
CN103920034B CN201410144869.3A CN201410144869A CN103920034B CN 103920034 B CN103920034 B CN 103920034B CN 201410144869 A CN201410144869 A CN 201410144869A CN 103920034 B CN103920034 B CN 103920034B
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chinese medicine
chemotherapy
medicine composition
indigo naturalis
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CN103920034A (en
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袁双虎
王素贞
于清溪
刘志国
刘宁
侯文红
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Shandong Tumor Hospital
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SHANDONG TUMOR HOSPITAL
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Priority to CN201510947572.5A priority Critical patent/CN105535577A/en
Priority to CN201510947575.9A priority patent/CN105535578A/en
Priority to CN201510947544.3A priority patent/CN105535573A/en
Priority to CN201410144869.3A priority patent/CN103920034B/en
Application filed by SHANDONG TUMOR HOSPITAL filed Critical SHANDONG TUMOR HOSPITAL
Priority to CN201510947552.8A priority patent/CN105535576A/en
Priority to CN201510947547.7A priority patent/CN105535575A/en
Priority to CN201510947546.2A priority patent/CN105535574A/en
Priority to CN201510947542.4A priority patent/CN105497610A/en
Priority to CN201510947539.2A priority patent/CN105497609A/en
Priority to CN201510947550.9A priority patent/CN105497611A/en
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Abstract

The invention discloses the Chinese medicine composition of a kind of ameliorate tumor chemotherapy of patients side reaction, take off the primary raw material of stating weight proportion and be prepared from: blue or green caulis bambusae in taenian 6-12 part, the bighead atractylodes rhizome (bran stir-fry) 6-15 part, coptis 4-8 part, red sage root 6-12 part, bletilla 5-12 part, rheum officinale 3-6 part, scouring rush 5-11 part, bark of official magnolia 6-12 part, indigo naturalis 3-6 part, rhizoma cyperi (vinegar) 4-8 part, myrrh 6-18 part, costus root 6-12 part, chorion ovi 9-15 part, day smart 4-9 part of name, pinellia 4-12 part. Excellent results of the present invention also shows: the present invention, completely according to the body and mind feature of traditional Chinese medicine principle and tumour patient, can effectively alleviate chemotherapy side effect; Selected materials is all traditional Chinese medicine material, without any side effects.

Description

Chinese medicine composition and the method for making of the side reaction of ameliorate tumor chemotherapy of patients
Technical field
The invention discloses a kind of Chinese medicine composition, particularly the Chinese traditional medicine composition of a kind of ameliorate tumor chemotherapy of patients side reactionThing and method for making. The invention belongs to traditional Chinese medicine field.
Background technology
Malignant tumour is a large disease of serious threat human health and life, chemotherapy be treatment malignant tumour method itOne. Chemotherapy, i.e. chemotherapy, is to utilize chemicals kill the growth and breeding of tumour cell, inhibition tumor cell and promote swollenA kind of therapeutic modality of the differentiation of oncocyte, it is that a kind of systemic treatment means are to primary tumor, MET and subclinical transferKitchen range all has therapeutic action. In recent years the progress of the continuing to bring out of cancer therapy drug, science and technology and Combination chemotherapy rationallyApplication has had the chemotherapeutic efficacy of tumour to significantly improve, but chemotherapy belongs to the scope of " sending an expedition against ", tends to just occurring attacking evil woundSituation, chemotherapeutic treatment tumour, in killing tumor cell, is also together killed normal cell and immunity (opposing) cell,So chemotherapy is the methods for the treatment of of a kind of " destruction of all people good and bad alike ". The main side reaction of chemotherapy is bone marrow suppression, digestive tract reaction and godThrough toxin reaction etc., particularly middle and advanced stage tumour or weakly patient, blindly uses chemotherapy, not only can cause the state of an illness rapidWorsen, more can accelerate patient's death.
The side reaction main manifestations of chemotherapy is:
1. nervous system toxicity: mainly refer to that chemotherapeutics is to the neural detrimental effect that produces of peripheral terminals, patient can occurAcroanesthesia, acra is insensitive etc.
2. feel sick, vomit and poor appetite: after accepting chemotherapy, because drug effect can be along with medicine concentration in vivoPatient just has power, so there will be degradation symptom under lassitude, n and V and appetite after accepting chemotherapy.
3. bone marrow suppression: great majority all can cause bone marrow suppression to the effective chemotherapeutics of malignant tumor patient, performanceFor leucocyte and blood platelet decline, very degradation under person's red blood cell, hemochrome.
4. diarrhoea: diarrhoea is a common problem for the patient of chemotherapy. Diarrhoea can be very serious, even dangerAnd life, but diarrhoea is also the common side reaction of chemotherapy.
5. fatigue: malignant tumor patient is at chemotherapeutic period, because the time is longer, so patient just needs a large amount of human bodies that consumeSome energy, the pressure that disease is brought, every day come and go treatment and radiation all can cause fatigue to Normocellular impact.
6. alopecia: hair follicle is being subject to the impact of chemotherapeutic agent, hair loss can occur in conventionally accepts chemotherapy for several timesAfterwards, it is severe than usual that you can think that hair falls, and after adding up repeatedly, hair is comparatively lax, easily sees scalp.
Malignant tumour belongs to that the traditional Chinese medical science " is amassed ", the category of " consumptive disease ", exists the performance of body ressitance weakened while pathogenic factors prevailing. And due to the course of diseaseBe continuous, can cause the phenomenon of " chronic disease involving kidney ". After accepting chemotherapy, it is weakened body resistance, and disease is more obvious, hinders in stomach and feels sick and receiveSlow-witted, to hinder in dizziness and tinnitus of kidney, dedentition is sent out de-, and soreness of waist foot is soft, hinders in palpitation of the heart. Therefore, ameliorate tumor chemotherapy of patientsSide reaction has very important medical value.
Publication number is CN1357354A(application number 01114965.5) Chinese patent literature a kind of by name " controlling disclosedTreat medicine of concurrent chemoradiotherapy of malignant tumor side reaction and preparation method thereof ", it is by Radix Codonopsis, the Radix Astragali, Poria cocos, the bighead atractylodes rhizome, the fruit of glossy privet, matrimony vineSub, burnt short, bristly hair or beard, Radix Glycyrrhizae are made. Its formula preparation method complexity, is not suitable for individual's operation. Application publication number is CN102327390A(application number 201110314905.2) Chinese patent literature disclose that a kind of by name " it is secondary that one is prevented and treated chemotherapy poisonThe Chinese prescription of reaction and the preparation method of pill thereof ", this Chinese prescription has donkey-hide gelatin, ginseng, Chinese cassia tree, Ligusticum wallichii, prepared rhizome of rehmannia, FuSiberian cocklebur, the bighead atractylodes rhizome, the Radix Astragali, Radix Angelicae Sinensis, the root of herbaceous peony, the seed of Chinese dodder, the fruit of Chinese wolfberry, radix cyathulae, dried orange peel, glossy ganoderma, saline cistanche, pilose antler, Moschus, clock breastStone, Morinda officinalis, monkshood, sea cucumber, Radix Glycyrrhizae, deer horn glue, yellow rice wine are according to certain weight proportion composition. Its formula medicinal material is numerous, andIndivedual price of medicinal materials are higher, increased patient's financial burden.
Summary of the invention
For the deficiencies in the prior art, the object of this invention is to provide a kind of prepare simple, be easy to carry, taking convenienceChinese medicine composition and the method for making of the side reaction of ameliorate tumor chemotherapy of patients. This Chinese medicine composition is completely according to the body and mind spy of tumour patientPoint development, determined curative effect and without any side effects.
Technical scheme of the present invention is:
The Chinese medicine composition of ameliorate tumor chemotherapy of patients side reaction, takes off the primary raw material of stating weight proportion and is prepared from:Blue or green caulis bambusae in taenian 6-12 part, the bighead atractylodes rhizome (bran stir-fry) 6-15 part, coptis 4-8 part, red sage root 6-12 part, bletilla 5-12 part, rheum officinale 3-6 part, scouring rush5-11 part, bark of official magnolia 6-12 part, indigo naturalis 3-6 part, rhizoma cyperi (vinegar) 4-8 part, myrrh 6-18 part, costus root 6-12 part, chorion ovi 9-15Part, day smart 4-9 part of name, pinellia 4-12 part.
The Chinese medicine composition of ameliorate tumor chemotherapy of patients side reaction, preferred scheme is to take off and state the main of weight proportionRaw material is prepared from: blue or green caulis bambusae in taenian 8-10 part, and the bighead atractylodes rhizome (bran stir-fry) 8-12 part, coptis 5-7 part, red sage root 8-10 part, bletilla 7-10 part, largeYellow 3-5 part, scouring rush 7-9 part, bark of official magnolia 8-10 part, indigo naturalis 4-6 part, rhizoma cyperi (vinegar) 5-7 part, myrrh 10-14 part, costus root 8-10Part, chorion ovi 11-13 part, day smart 5-7 part of name, pinellia 7-9 part.
The Chinese medicine composition of ameliorate tumor chemotherapy of patients side reaction, the scheme being more preferably is, takes off and states weight proportionPrimary raw material is prepared from: 9 parts of blue or green caulis bambusae in taenians, 10 parts of the bighead atractylodes rhizomes (bran stir-fry), 6 parts of the coptiss, 9 parts of the reds sage root, 8 parts of bletillas, 4 parts of rheum officinales, wood8 parts of thieves, 9 parts of the barks of official magnolia, 5 parts of indigo naturalis, 6 parts of rhizoma cyperis (vinegar), 12 parts of myrrhs, 9 parts of costus root, 12 parts of chorion ovis, 6 parts of day name essences, ginger8 parts of the tuber of pinellia.
The present invention also provides above-mentioned Chinese medicine composition has been made to pharmaceutically acceptable pulvis, aqua, paste, particleAgent, tablet or capsule.
The preparation method of described pulvis is:
(1) rheum officinale, indigo naturalis are ground into respectively to fine powder, cross 60-120 mesh sieve and (preferably, cross 85-115 mesh sieve; More excellentChoosing, cross 105 mesh sieves);
(2) by blue or green caulis bambusae in taenian, the bighead atractylodes rhizome (bran stir-fry), the coptis, the red sage root, bletilla, scouring rush, the bark of official magnolia, rhizoma cyperi (vinegar), myrrh, costus root,Chorion ovi, day name essence and pinellia co-grinding are crossed 85-135 mesh sieve and (preferably, are crossed 100-120 mesh sieve; Be more preferably mistake110 mesh sieves);
(3) step (1) and (2) gained are mixed.
The preparation method of described aqua is:
(1) rheum officinale, indigo naturalis are ground into respectively to fine powder, cross 60-120 mesh sieve and (preferably, cross 85-115 mesh sieve; More excellentChoosing, cross 105 mesh sieves);
(2) by blue or green caulis bambusae in taenian, the bighead atractylodes rhizome (bran stir-fry), the coptis, the red sage root, bletilla, scouring rush, the bark of official magnolia, rhizoma cyperi (vinegar), myrrh, costus root,Chorion ovi, day name essence and pinellia are placed in marmite, and adding water, (water consumption is doubly (preferably, the 3-4 of 2.5-4.5 of bulk drug gross weightDoubly; Be more preferably 3.5 times)) decoct 2 times, 1.2-2.4 hour for the first time (preferred, 1.5-2.0 hour; Be more preferably,1.8 hours), 0.8-1.2 hour for the second time (preferred 0.9-1.1 hour; Be more preferably 1.0 hours), filtrate merges, and putsCold;
(3) rheum officinale and indigo naturalis after step (1) pulverizing are added to step (2) gained liquid, sterile packaged.
The preparation method of described paste is:
(1) rheum officinale, indigo naturalis are ground into respectively to fine powder, (preferred, 85-115 mesh sieve, more excellent excessively for 60-120 mesh sieve excessivelyChoosing, cross 105 mesh sieves);
(2) by blue or green caulis bambusae in taenian, the bighead atractylodes rhizome (bran stir-fry), the coptis, the red sage root, bletilla, scouring rush, the bark of official magnolia, rhizoma cyperi (vinegar), myrrh, costus root,Chorion ovi, day name essence and pinellia are placed in marmite, and adding water, (water consumption is doubly (preferably, the 3-4 of 2.5-4.5 of bulk drug gross weightDoubly; Be more preferably 3.5 times)) decoct 2 times, 1.2-2.4 hour for the first time (preferred, 1.5-2.0 hour; Be more preferably,1.8 hours), 0.8-1.2 hour for the second time (preferred 0.9-1.1 hour; Be more preferably 1.0 hours), filtrate merges, filterCross, concentrated that relative density is 1.36-1.38(48 DEG C) clear cream;
(3) rheum officinale and indigo naturalis after step (1) pulverizing are added to the clear cream of step (2) gained, sterile packaged.
The preparation method of described granule is:
(1) rheum officinale, indigo naturalis are ground into respectively to fine powder, cross 60-120 mesh sieve and (preferably, cross 85-115 mesh sieve; More excellentChoosing, cross 105 mesh sieves);
(2) by blue or green caulis bambusae in taenian, the bighead atractylodes rhizome (bran stir-fry), the coptis, the red sage root, bletilla, scouring rush, the bark of official magnolia, rhizoma cyperi (vinegar), myrrh, costus root,Chorion ovi, day name essence and pinellia are placed in marmite, and adding water, (water consumption is doubly (preferably, the 3-4 of 2.5-4.5 of bulk drug gross weightDoubly; Be more preferably 3.5 times)) decoct 2 times, 1.2-2.4 hour for the first time (preferred, 1.5-2.0 hour; Be more preferably,1.8 hours), 0.8-1.2 hour for the second time (preferred 0.9-1.1 hour; Be more preferably 1.0 hours), filtrate merges, filterCross, concentrated that relative density is 1.36-1.38(48 DEG C) clear cream;
(3) qinghuo reagent 0.8-1.2 part (preferably, 0.9-1.1 part; Be more preferably 1.0 parts), sucrose 1.5-3.5 part(preferred, 2-3 part; Be more preferably 2.5 parts), and dextrin 0.8-1.2 part (preferred, 0.9-1.1 part; Be more preferably 1.0Part), after mixing, add step (1) gained rheum officinale and indigo naturalis fine powder, mix, granulation, dry, obtain granule.
The preparation method of described tablet is: by (excellent according to 0.3-0.5g/ sheet claim 5 gained Chinese traditional medicine composition medicinal powderChoosing, 0.35-0.45g/ sheet; Be more preferably 0.4g/ sheet) metering, according to the preparation for processing of tablet be pressed into circle orThe sheet formulation of other shapes.
The preparation method of described capsule is: by (excellent according to 0.4-0.6g/ grain claim 5 gained Chinese traditional medicine composition medicinal powderChoosing, 0.45-0.55g/ grain; Be more preferably 0.5g/ grain) metering, be processed into capsule shape according to the preparation for processing of capsuleFormulation.
The pharmacology of the present invention's main Chinese medicine material used is as follows:
Blue or green caulis bambusae in taenian: nature and flavor: taste is sweet, are slightly cold. Gui Jing: lung, stomach, gallbladder channel. Effect: clearing heat and eliminating phlegm, relieves restlessness and prevents vomiting. Cure mainly: phlegmHeat cough, courage fire is held phlegm under the arm, dysphoria with smothery sensation vomiting, eye is lost in palpitation with fear, apoplexy phlegm fan, aphasia with stiff tongue, gastropyretic vomiting, pernicious vomiting, movement of the foetus is notPeace.
The bighead atractylodes rhizome (bran stir-fry): nature and flavor: bitter, sweet, temperature. Gui Jing: return spleen, stomach warp. Effect: strengthening the spleen and replenishing qi, eliminating dampness Li Shui, onlySweat, antiabortive. Cure mainly: deficiency-weakness of spleen-QI weak, the few abdominal distension of food, the constipation of having loose bowels, the difficult urination of fluid retention stagnating in the interior, oedema, phlegm and retained fluid is dizzyDizzy, cold-dampness numbness, bodily pain, spontaneous perspiration due to deficiency of vital energy, fetal irritability.
The coptis: nature and flavor: bitter, cold. Gui Jing: the thoughts of returning home, liver, stomach, large intestine channel. Effect: clearing heat-fire, eliminating dampness, removing toxic substances. MainControl: pyreticosis heresy enters the high heat of the heart channel of Hang-Shaoyin, agitation, delirium or heat are contained the nosebleed of telling of compeling the absurd row of blood, and damp and hot bear ruffian is had loose bowels, dysentery, internal heat is highThe vexed insomnia of Sheng, gastropyretic vomiting, rapid digestion of food and polyorexia, irascibility red eye, swell pain, and pathopyretic ulcer, serious case of furuncle septicemia, swelling and aching of gum, mouthfulThe raw sore of tongue, Ting ear, hemorrhoid blood, eczema, scalds.
The red sage root: nature and flavor: bitter, is slightly cold. Gui Jing: the thoughts of returning home, pericardium, Liver Channel. Effect: promoting blood circulation, menstruction regulating and pain relieving, relieving restlessness peaceGod, the cool blood carbuncle that disappears. Cure mainly: menoxenia, dysmenorrhoea, through closing, the stomachache of being retarded by silt postpartum, trusted subordinate's pain ， lumps in the chest and abdomen, hot numbness is swollenBitterly, traumatic injury, heat enters ying blood, haves the fidgets, vexed insomnia, carbuncle pyogenic infections from tumour or sore.
Bletilla: nature and flavor: bitter, sweet, puckery, is slightly cold. Gui Jing: return lung, kidney channel. Effect: astringing to arrest bleeding, detumescence and promoting granulation. Cure mainly:Spitting of blood, spits blood, and bleeding from five sense organs or subcutaneous tissue, has blood in stool, traumatism and bleeding, and carbuncle pyogenic infections from tumour or sore, scalds and burns, rhagadia manus et pedis, anal fissure.
Rheum officinale: nature and flavor: bitter, cold. Gui Jing: stomach, large intestine, liver, the spleen channel. Effect: attack stagnant, clearing away damp-heat, purging intense heat, cool blood,The stasis of blood of dispelling, removing toxic substances. Cure mainly: solid cubic content constipation, the thermojunction feeling of stuffiness in chest; Damp-heat dysentery, jaundice, gonorrhoea, oedema abdomen is full, difficult urination; Hot eyes, pharynxLarynx swells and ache, aphthae, and gastropyretic vomiting, spits blood, spitting of blood, bleeding from five sense organs or subcutaneous tissue, has blood in stool, hematuria; Hold blood, through closing, the stomachache of being retarded by silt postpartum ， Disorder lump in the abdomenGather, traumatic injury, hot malicious large carbuncle, erysipelas, scalds.
Scouring rush: nature and flavor: sweet, the micro-hardship of taste, flat. Gui Jing: return lung, liver, gallbladder channel. Effect: wind-dispelling heat-dissipating, removing nebula, hemostasis.Cure mainly: wind-heat hot eyes, the raw cloudiness of order, tearing against wind, discharging fresh blood stool, hemorrhoid blood, bloody flux, married woman is mensostaxis, prolapse of the anus.
The bark of official magnolia: nature and flavor: bitter, pungent, warm in nature. Gui Jing: return spleen, stomach, large intestine channel. Effect: promoting the circulation of qi dampness elimination, warming middle energizer to relieve pain, fallContrary relievining asthma. Cure mainly: stagnation of QI due to dyspepsia; Abdominal distention constipation; Damp retention in middle-jiao, gastral cavity ruffian is vomited and diarrhoea; Phlegm is stopped up the circulation of vital energy in the wrong direction; Fullness sensation in chest is breathed with cough.
Indigo naturalis: nature and flavor: taste is salty, cold. Gui Jing: return liver, lung, stomach warp. Effect: heat-clearing, cool blood, removing toxic substances. Cure mainly: warm malicious spotRash, spits blood, bleeding from five sense organs or subcutaneous tissue, and spitting of blood, pediatric epilepsy scared, liver-fire attacking lung cough, abscess of throat, erysipelas, mumps, sore is swollen, snake bite and insect sting.
Rhizoma cyperi (vinegar): nature and flavor: pungent, sweet, the micro-hardship of taste, flat. Gui Jing: return liver, tri-jiao channel. Effect: the Xie Yu that regulates the flow of vital energy, menstruation regulating, peaceTire. Cure mainly: the distending pain in hypochondrium, swollen breasts, hernia pain, irregular menstruation, the full pain of gastral cavity abdomen ruffian, belch acid regurgitation, the evil of vomitting, through row abdomenBitterly, under uterine bleeding band, fetal irritability.
Myrrh: nature and flavor: bitter, pungent, flat. Gui Jing: return spleen, the heart, Liver Channel. Effect: the stasis of blood of dispelling, detumescence, analgesic therapy. Cure mainly: chest abdomenBitterly, dysmenorrhoea, through Bi ， Disorder lump in the abdomen, beats and swells and ache, the carbuncle sore that swells, red eye, swell pain.
Costus root: nature and flavor: taste is pungent, bitter, temperature. Gui Jing: return lung, liver, the spleen channel. Effect: promoting qi circulation and relieving pain, warming middle-JIAO for easing the stomach. Cure mainly:Chest and abdomen swelling and pain, vomiting, has loose bowels, and dysentery is tenesmus.
Chorion ovi: nature and flavor: taste is sweet is light, flat. Gui Jing: return lung channel. Effect: nourishiing yin to clear away the lung-heat, sore, the screen that disappears, synthetism. Cure mainly:Chronic cough is breathed heavily for a long time, pharyngalgia aphonia, unhealing ulcer, the raw ocular of order, vertigo, trauma fracture.
It name essence: base is former: be the herb of composite family Carpesium plant sky name essence. Nature and flavor: taste bitter, acrid, cold. Gui Jing: return liver,Lung channel. Effect: clearing heat and eliminating phlegm, removing toxic substances desinsection, broken stasis of blood hemostasis. Cure mainly: acute tonsillitis larynx numbness, anxious chronic infantile convulsion, toothache, furunculosis swells and ache, hemorrhoidFistula, itchy skin eruption, venomous snake bite, malnutrition due to parasitic infestation, blood lump in the abdomen, spits blood, bleeding from five sense organs or subcutaneous tissue, blood drenches, traumatic bleeding
Pinellia: nature and flavor: taste is pungent, warm. Gui Jing: return spleen, stomach, lung channel. Effect: stopping nausea and vomiting by lowering the adverse flow of QI. Cure mainly: vomiting gastric disorder causing nausea, chestGastral cavity ruffian is vexed, globus hysteriocus.
Chinese medicine composition of the present invention, based on traditional Chinese medical herbal treatment chemotherapy side effect principle, is to study lot of documents, medicineOn the basis of science and engineering work and clinical testing, make. This Chinese medicine composition is completely according to traditional Chinese medicine principle and malignant tumor patientBody and mind feature, the side reaction that chemotherapy is caused has good result for the treatment of.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited to this.
The Chinese medicine composition of embodiment 1 ameliorate tumor chemotherapy of patients side reaction, takes off the primary raw material system of stating weight proportionStandby form (every part of 10g): 9 parts of blue or green caulis bambusae in taenians, 10 parts of the bighead atractylodes rhizomes (bran stir-fry), 6 parts of the coptiss, 9 parts of the reds sage root, 8 parts of bletillas, 4 parts of rheum officinales, scouring rush8 parts, 9 parts of the barks of official magnolia, 5 parts of indigo naturalis, 6 parts of rhizoma cyperis (vinegar), 12 parts of myrrhs, 9 parts of costus root, 12 parts of chorion ovis, 6 parts of day name essences, ginger half8 parts of summers.
The preparation method of the Chinese traditional medicine composition medicinal powder of above-mentioned ameliorate tumor chemotherapy of patients side reaction is:
(1) rheum officinale, indigo naturalis are ground into respectively to fine powder, cross 105 mesh sieves;
(2) by blue or green caulis bambusae in taenian, the bighead atractylodes rhizome (bran stir-fry), the coptis, the red sage root, bletilla, scouring rush, the bark of official magnolia, rhizoma cyperi (vinegar), myrrh, costus root,Chorion ovi, day name essence and pinellia co-grinding are crossed 110 mesh sieves;
(3) step (1) and (2) gained are mixed.
Pulvis instructions of taking of the present invention: divide 5g/ bag by pulvis, adopt every day 2-3 time, each one bag, use warm boiled water,7 days courses for the treatment of.
Model case one Ke XX, the age: 51 years old, sex: man. Within 2008, suffer from Esophageal Middle Segment malignant tumour, accept in hospital, there is the symptoms such as acroanesthesia, n and V, poor appetite, health be tired after chemotherapy in chemotherapy. Taking this enforcement gained alleviatesThe Chinese traditional medicine composition medicinal powder of Chemotherapy on Patient with Tumor side reaction, adopts every day 3 times, each one bag, with warm boiled water, 7 days oneThe course for the treatment of. Take 15 days, patient's appetite strengthens to some extent, and malaise symptoms alleviates; Take 1 month, malaise symptoms is clearly better, and muscle power increasesBy force; Continue to take 2 months, patient's readme malaise symptoms disappears.
The Chinese medicine composition of embodiment 2 ameliorate tumor chemotherapy of patients side reactions, takes off the primary raw material system of stating weight proportionStandby form (every part of 20g): 9 parts of blue or green caulis bambusae in taenians, 10 parts of the bighead atractylodes rhizomes (bran stir-fry), 6 parts of the coptiss, 9 parts of the reds sage root, 8 parts of bletillas, 4 parts of rheum officinales, scouring rush8 parts, 9 parts of the barks of official magnolia, 5 parts of indigo naturalis, 6 parts of rhizoma cyperis (vinegar), 12 parts of myrrhs, 9 parts of costus root, 12 parts of chorion ovis, 6 parts of day name essences, ginger half8 parts of summers.
The preparation method of the Chinese medicine composition paste of above-mentioned ameliorate tumor chemotherapy of patients side reaction is:
(1) rheum officinale, indigo naturalis are ground into respectively to fine powder, cross 105 mesh sieves;
(2) by blue or green caulis bambusae in taenian, the bighead atractylodes rhizome (bran stir-fry), the coptis, the red sage root, bletilla, scouring rush, the bark of official magnolia, rhizoma cyperi (vinegar), myrrh, costus root,Chorion ovi, day name essence and pinellia are placed in marmite, and add water (water consumption is 3.5 times of bulk drug gross weight) decocts 2 times, for the first time1.8 hours, 1.0 hours for the second time, filtrate merged, and filtered, concentrated that relative density is 1.36-1.38(48 DEG C) clear cream;
(3) rheum officinale and indigo naturalis after step (1) pulverizing are added to the clear cream of step (2) gained, sterile packaged.
Paste instructions of taking of the present invention: paste adopts every day 2 times, each 6-8g, takes 7 according to the ratio bath of 1:10It course for the treatment of.
The old XX of model case two, the age: 56 years old, sex: female. The right Rupture of Hepatocellular Carcinoma of primary in 2007, acute disease is cut open the belly, excision7 × 8cm cancer piece, treats residual cancer by the method for chemotherapy afterwards, and patient's readme chemotherapy can cause some side reactions, mainly contains: tired,Hypoimmunity, poor appetite, One's spirits are drooping, drowsiness etc. Take the present embodiment gained ameliorate tumor chemotherapy of patients side reactionChinese medicine composition paste, adopts every day 2 times, and each 8g takes 7 days courses for the treatment of according to the ratio bath of 1:10. Take 10My god, patient's state of mind takes a turn for the better, and drowsiness situation alleviates; Take 1 month, appetite strengthens to some extent, and malaise symptoms fades away; ContinueTake 2 months, do not occur any discomfort when patient takes, the symptom that feels uneasy disappears completely.
The Chinese medicine composition of embodiment 3 ameliorate tumor chemotherapy of patients side reactions, takes off the primary raw material system of stating weight proportionStandby form (every part of 30g): 9 parts of blue or green caulis bambusae in taenians, 10 parts of the bighead atractylodes rhizomes (bran stir-fry), 6 parts of the coptiss, 9 parts of the reds sage root, 8 parts of bletillas, 4 parts of rheum officinales, scouring rush8 parts, 9 parts of the barks of official magnolia, 5 parts of indigo naturalis, 6 parts of rhizoma cyperis (vinegar), 12 parts of myrrhs, 9 parts of costus root, 12 parts of chorion ovis, 6 parts of day name essences, ginger half8 parts of summers.
The preparation method of the Chinese medicinal composition granules of above-mentioned ameliorate tumor chemotherapy of patients side reaction is:
(1) rheum officinale, indigo naturalis are ground into respectively to fine powder, cross 105 mesh sieves;
(2) by blue or green caulis bambusae in taenian, the bighead atractylodes rhizome (bran stir-fry), the coptis, the red sage root, bletilla, scouring rush, the bark of official magnolia, rhizoma cyperi (vinegar), myrrh, costus root,Chorion ovi, day name essence and pinellia are placed in marmite, and add water (water consumption is 3.5 times of bulk drug gross weight) decocts 2 times, for the first time1.8 hours, 1.0 hours for the second time, filtrate merged, and filtered, concentrated that relative density is 1.36-1.38(48 DEG C) clear cream;
(3) 1.0 parts of qinghuo reagents, 2.5 parts of sucrose, 1.0 parts, dextrin, adds step (1) gained rheum officinale and indigo naturalis fine powder after mixing,Mix, granulation, dry, obtain granule.
Granule instructions of taking of the present invention: divide 8g/ bag by granule, every day 2-3 time, each one bag, with warm boiled water,7 days courses for the treatment of.
Model case three Xiao XX, the age: 69 years old, sex: female. It is pernicious that find that at examination in hospital liver occurs in June, 2009Tumour, because tumour is larger, should not perform the operation, and therefore do chemotherapy and alleviate slight illness, but some side reactions appears in chemotherapy: acraInsensitive, n and V, diarrhoea, health are weak, alopecia etc. Take the side reaction of the present embodiment gained ameliorate tumor chemotherapy of patientsChinese medicinal composition granules, adopt every day 3 times, each one bag, with warm boiled water, 7 days courses for the treatment of. Take 21 days, suffer fromPerson's n and V alleviates, and alopecia also alleviates; Take 2 months, patient's malaise symptoms fades away, and acra sensation is sensitive before;Continue to take 2 months, patient's symptom that feels uneasy disappears completely.
The Chinese medicine composition of embodiment 4 ameliorate tumor chemotherapy of patients side reactions, takes off the primary raw material system of stating weight proportionStandby form (every part of 40g): 9 parts of blue or green caulis bambusae in taenians, 10 parts of the bighead atractylodes rhizomes (bran stir-fry), 6 parts of the coptiss, 9 parts of the reds sage root, 8 parts of bletillas, 4 parts of rheum officinales, scouring rush8 parts, 9 parts of the barks of official magnolia, 5 parts of indigo naturalis, 6 parts of rhizoma cyperis (vinegar), 12 parts of myrrhs, 9 parts of costus root, 12 parts of chorion ovis, 6 parts of day name essences, ginger half8 parts of summers.
The preparation method of the Chinese medicine composition tablet of above-mentioned ameliorate tumor chemotherapy of patients side reaction is:
(1) rheum officinale, indigo naturalis are ground into respectively to fine powder, cross 105 mesh sieves;
(2) by blue or green caulis bambusae in taenian, the bighead atractylodes rhizome (bran stir-fry), the coptis, the red sage root, bletilla, scouring rush, the bark of official magnolia, rhizoma cyperi (vinegar), myrrh, costus root,Chorion ovi, day name essence and pinellia co-grinding are crossed 110 mesh sieves;
(3) step (1) and (2) gained are mixed to obtain to pulvis;
(4) step (3) gained pulvis is measured according to 0.4g/ sheet, be pressed into circle according to the preparation for processing of tabletOr the sheet formulation of other shapes.
Tablets method of the present invention: tablet adopts every day 3 times, each 5-8 sheet, with warm boiled water, treatment in 7 daysJourney.
Model case four woods XX, the age: 37 years old, sex: man. Patient carries out artificial strand in February, 2008 because of giant cell tumor of boneBone replacement operation, in July, 2008, tumour extensively shifted to two lungs, in August, 2008 CT Pulmonary metastasis focuses maximum gauge 14 × 14cm,Heating, cough breathe heavily, bodily pain, alleviate slight illness by chemotherapy, but chemotherapy causes some side reactions: weak all over, One's spirits are drooping, foodWant lowly and with phenomenons such as n and Vs, take anti-chemotherapy side effect medicine, all without positive effect. Take the present embodiment gainedThe Chinese medicine composition tablet of ameliorate tumor chemotherapy of patients side reaction, adopts every day 3 times, and each 8, with warm boiled water, 7 days oneThe individual course for the treatment of. Take 15 days, patient's malaise symptoms alleviates to some extent, and the food of receiving is gradually many; Take 1 month, n and V phenomenon disappears, spiritCondition improvement, malaise symptoms fades away; Continue to take 2 months, patient's self-induction is without side reaction.
The Chinese medicine composition of embodiment 5 ameliorate tumor chemotherapy of patients side reactions, takes off the primary raw material system of stating weight proportionStandby form (every part of 50g): 9 parts of blue or green caulis bambusae in taenians, 10 parts of the bighead atractylodes rhizomes (bran stir-fry), 6 parts of the coptiss, 9 parts of the reds sage root, 8 parts of bletillas, 4 parts of rheum officinales, scouring rush8 parts, 9 parts of the barks of official magnolia, 5 parts of indigo naturalis, 6 parts of rhizoma cyperis (vinegar), 12 parts of myrrhs, 9 parts of costus root, 12 parts of chorion ovis, 6 parts of day name essences, ginger half8 parts of summers.
The preparation method of the Chinese medicinal composition capsules of above-mentioned ameliorate tumor chemotherapy of patients side reaction is:
(1) rheum officinale, indigo naturalis are ground into respectively to fine powder, cross 105 mesh sieves;
(2) by blue or green caulis bambusae in taenian, the bighead atractylodes rhizome (bran stir-fry), the coptis, the red sage root, bletilla, scouring rush, the bark of official magnolia, rhizoma cyperi (vinegar), myrrh, costus root,Chorion ovi, day name essence and pinellia co-grinding are crossed 110 mesh sieves;
(3) step (1) and (2) gained are mixed to obtain to pulvis;
(4) step (3) gained pulvis is measured according to 0.5g/ grain, be processed into capsule according to the preparation for processing of capsuleShape formulation.
Capsule instructions of taking of the present invention: capsule adopts every day 3 times, each 6-10 grain, with warm boiled water, treatment in 7 daysJourney.
Model case five Wu XX, the age: 55 years old, sex: female. Within 2010, find right tonsil malignant lymphoma, through chemotherapy,Swollen thing disappears, the side reactions such as the vomiting but chemotherapy causes nausea, appetite are low, drowsiness, lassitude. The pair causing for alleviating chemotherapyReaction, patient takes the Chinese medicinal composition capsules agent of the present embodiment gained ameliorate tumor chemotherapy of patients side reaction, adopts every day 3Inferior, each 10, with warm boiled water, 7 days courses for the treatment of. Take 1 month, patients ' vomiting alleviates, and drowsiness situation also subtractsGently; Take 2 months, malaise symptoms improves, and the state of mind takes a turn for the better; Continue to take 2 months, patient is without malaise symptoms.
The Chinese medicine composition of embodiment 6 ameliorate tumor chemotherapy of patients side reactions, takes off the primary raw material system of stating weight proportionStandby form (every part of 60g): 9 parts of blue or green caulis bambusae in taenians, 10 parts of the bighead atractylodes rhizomes (bran stir-fry), 6 parts of the coptiss, 9 parts of the reds sage root, 8 parts of bletillas, 4 parts of rheum officinales, scouring rush8 parts, 9 parts of the barks of official magnolia, 5 parts of indigo naturalis, 6 parts of rhizoma cyperis (vinegar), 12 parts of myrrhs, 9 parts of costus root, 12 parts of chorion ovis, 6 parts of day name essences, ginger half8 parts of summers.
The preparation method of the Chinese medicine composition aqua of above-mentioned ameliorate tumor chemotherapy of patients side reaction is:
(1) rheum officinale, indigo naturalis are ground into respectively to fine powder, cross 105 mesh sieves;
(2) by blue or green caulis bambusae in taenian, the bighead atractylodes rhizome (bran stir-fry), the coptis, the red sage root, bletilla, scouring rush, the bark of official magnolia, rhizoma cyperi (vinegar), myrrh, costus root,Chorion ovi, day name essence and pinellia are placed in marmite, and add water (water consumption is 3.5 times of bulk drug gross weight) decocts 2 times, for the first time1.8 hours, 1.0 hours for the second time, filtrate merged, and lets cool;
(3) rheum officinale and indigo naturalis after step (1) pulverizing are added to step (2) gained liquid, sterile packaged.
Aqua instructions of taking of the present invention: aqua adopts every day 2 times (warm), each 300-500ml, 7 days courses for the treatment of.
The clinical practice of the Chinese medicine composition aqua of test example 1 embodiment 6 gained ameliorate tumor chemotherapy of patients side reactions:In March, 2009-2012 year February, screen 120 routine patients in 5 hospitals, wherein women's 61 examples, the male sex's 59 examples, oldest 76Year, minimal ages 35 years old. Test 3 weeks before, carries out Continuous Observation to this crowd, records symptom and variation, is divided at random two groups,Experimental group and control group, experimental group is taken embodiment 6 products obtained therefroms, and control group is taken other medicine (holy liquid oral liquid, selenium Wei KangEtc. conventional medicine). Using method is: take every day twice (warm), each 300m1-500m1(adjusts to some extent depending on concrete conditionWhole), 7 days courses for the treatment of. Curative effect situation criterion: cure: take a course for the treatment of of this product, malaise symptoms disappears, energy and bodyPower obviously strengthens; Effective: take a course for the treatment of of this product, malaise symptoms alleviates or part disappears, and energy and muscle power strengthen; Invalid:Take a course for the treatment of of this product, malaise symptoms is unchanged. Result is as shown in table 1.
Table 1: take embodiment 6 products obtained therefrom result for the treatment of checkings
Experimental group Control group
Number of cases 100 20
Male sex's number of cases 51 8
Women's number of cases 49 12
Age (year) 35-76 35-76
Clinical cure number of cases 71 5
Effectively number of cases 28 10
Invalid number of cases 1 5
Total effective rate 99% 75%
Result for the treatment of: cure 71 examples (71%), effective 28 examples (28%), invalid 1 example (1%), total effective rate 99%. SuccessfulBe better than control group.
During taking, self-induction symptom and muscle power spirit thereof change as shown in table 2.
Table 2:
The present invention selects blue or green caulis bambusae in taenian, the bighead atractylodes rhizome (bran stir-fry), the coptis, the red sage root, chorion ovi, pinellia etc. to carry out compatibility, makes thisAfter a little drug regimens, produce synergy, more effectively ameliorate tumor chemotherapy of patients side reaction. Take 20 days, more than 53%Feel take a turn for the better to some extent, malaise symptoms improve; Take 40 days, more than 74% feeling takes a turn for the better to some extent, and malaise symptoms improves or disappearsLose, spirit, muscle power strengthen; Take 60 days, more than 97% feeling takes a turn for the better to some extent, and malaise symptoms improves or disappears, spiritual, physicalStrengthen the recovery from illness of some patients were self-induction. In experimental group, take more than 60 days, efficiently reach 95%, and control group is only 75%.
Finally it should be noted that embodiment is the detailed description of the invention of optimum of the present invention, be not limited to thisInvention, although the present invention is had been described in detail with reference to previous embodiment, for a person skilled in the art, it is complied withThe technical scheme that so can record aforementioned each embodiment is modified, or part technical characterictic is wherein equal to and is replacedChange. Within the spirit and principles in the present invention all, any amendment of doing, be equal to replacement, improvement etc., all should be included in the present inventionProtection domain within.

Claims (1)

1. the Chinese medicine composition of ameliorate tumor chemotherapy of patients side reaction, is characterized in that, gets the raw material of following portions by weight: blue or green bambooEat 9 parts, 10 parts of stir-baked RHIZOMA ATRACTYLDIS MACROCEPHALAE in bran, 6 parts of the coptiss, 9 parts of the reds sage root, 8 parts of bletillas, 4 parts of rheum officinales, 8 parts of scouring rushes, 9 parts of the barks of official magnolia, 5 parts of indigo naturalis, vinegar6 parts of rhizoma cyperis, 12 parts of myrrhs, 9 parts of costus root, 12 parts of chorion ovis, 6 parts of day name essences, 8 parts of pinellias; Preparation method is:
(1) rheum officinale, indigo naturalis are ground into respectively to fine powder, cross 105 mesh sieves;
(2) by blue or green caulis bambusae in taenian, stir-baked RHIZOMA ATRACTYLDIS MACROCEPHALAE in bran, the coptis, the red sage root, bletilla, scouring rush, the bark of official magnolia, prepared RHIZOMA CYPERI with vinegar, myrrh, costus root, chorion ovi,It name essence and pinellia are placed in marmite, boiling 2 times, and 1.8 hours for the first time, 1.0 hours for the second time, filtrate merged, and putsCold;
(3) rheum officinale and indigo naturalis after step (1) pulverizing are added to step (2) gained liquid, sterile packaged.
CN201410144869.3A 2014-04-12 2014-04-12 Chinese medicine composition and the method for making of the side reaction of ameliorate tumor chemotherapy of patients Expired - Fee Related CN103920034B (en)

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CN201510947544.3A CN105535573A (en) 2014-04-12 2014-04-12 Traditional Chinese medicine composition granules for mitigating side effects of chemotherapy for tumor patient
CN201410144869.3A CN103920034B (en) 2014-04-12 2014-04-12 Chinese medicine composition and the method for making of the side reaction of ameliorate tumor chemotherapy of patients
CN201510947542.4A CN105497610A (en) 2014-04-12 2014-04-12 Medicament for relieving side effects of chemotherapy
CN201510947552.8A CN105535576A (en) 2014-04-12 2014-04-12 Traditional Chinese medicine composition pulvis for mitigating side effects of chemotherapy for tumor patient
CN201510947575.9A CN105535578A (en) 2014-04-12 2014-04-12 Composition paste agent for mitigating side effects of chemotherapy for tumor patient
CN201510947546.2A CN105535574A (en) 2014-04-12 2014-04-12 Traditional Chinese medicine composition capsule for mitigating side effects of chemotherapy for tumor patient
CN201510947572.5A CN105535577A (en) 2014-04-12 2014-04-12 Medicament to reduce the side effects of chemotherapy for tumor patient
CN201510947539.2A CN105497609A (en) 2014-04-12 2014-04-12 Traditional Chinese medicine composition tablets capable of relieving chemotherapeutic side effects on tumor patient
CN201510947550.9A CN105497611A (en) 2014-04-12 2014-04-12 Pharmaceutical composition for relieving side effects of chemotherapy
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CN201510947544.3A Division CN105535573A (en) 2014-04-12 2014-04-12 Traditional Chinese medicine composition granules for mitigating side effects of chemotherapy for tumor patient
CN201510947552.8A Division CN105535576A (en) 2014-04-12 2014-04-12 Traditional Chinese medicine composition pulvis for mitigating side effects of chemotherapy for tumor patient
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CN105582371A (en) * 2015-09-21 2016-05-18 彭奋 Stomach nourishing preparation for relieving chemotherapy side effect of tumor patient and preparing method thereof
CN105687854A (en) * 2016-03-16 2016-06-22 魏晓梅 Nursing medicament for relieving cancer patient chemotherapy side reactions and preparation method thereof
CN106361904A (en) * 2016-11-12 2017-02-01 曹芳 Traditional Chinese medicine composition for relieving chemotherapy side reactions of tumor patients
CN109529042B (en) * 2018-12-19 2021-09-28 天津中新药业集团股份有限公司乐仁堂制药厂 Application of drug combination preparation and traditional Chinese medicine composition in preparation of chemotherapy drug synergistic detoxification agent
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