CN105106810A - Traditional Chinese medicine composition for treating ovarian cancer and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating ovarian cancer and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition for treating ovarian cancer. The traditional Chinese medicine composition is mainly prepared from the following active pharmaceutical ingredients in parts by mass: 6-9 parts of fructus galangae, 9-15 parts of crneate lespedeza, 10-14 parts of root of actinidia eriantha benth, 8-13 parts of root of Chinese eriosema, 9-16 parts of poria, 7-14 parts of philippine flemingia root, 6-12 parts of lignum dalbergiae odoriferae, 9-15 parts of all-grass of khas aletris, 7-16 parts of Japonese pearlwort herb, 8-14 parts of asiatic bilberry, 10-15 parts of ficus lyrata, 9-14 parts of fructus lycii, 7-15 parts of root of wallich swallowwort and 9-12 parts of linderae aggregate leaf. The traditional Chinese medicine composition for treating ovarian cancer is prepared according to clinical practice conclusions of many years, has the effects of detoxicating and relieving pain, and tonifying kidney and spleen, and is remarkable in curative effect.
Description
Technical field
The present invention relates to traditional Chinese medicine field, particularly relate to a kind of Chinese medicine composition and the method for making of curing ovarian cancer.
Background technology
Ovarian cancer is one of common tumor of female sex organ, and sickness rate is only second to cervical cancer and carcinoma of corpus uteri and arranges the 3rd, residence, accounts for 4% of women's whole body malignant tumor.Ovarian cancer can betide any age, but great majority betide ovarian function declines period by vigorous turn.Generally be more common in climacteric and menopausal women.Morbidity in less than 20 years old is less.Dissimilar ovarian cancer age distribution is also different.Epithelial ovarian cancer increases sharply for 40 years old later, and the peak age is 50-60 year, declines gradually by 70 years old later; The similar epithelial ovarian cancer of sex cord-stromal tumor, increases with the age and rises; And germ cell tumor is more common in the young woman before 20 years old, women's ovary cancer morbidity that is single or that do not give birth to is high.Because ovary is positioned at pelvic cavity deep, morbidity in early days can without or have lighter symptom, show the lump of uterus adnexa, with the gastrointestinal symptom of unknown cause, as inappetence, abdominal distention, become thin; Along with the development of the state of an illness, can the different symptom of corresponding appearance, mainly swell and swollen thing, pain or Irregular uterine bleeding etc. in abdomen at lower abdominal distention sense, abdominal part.The traditional Chinese medical science thinks that ovarian cancer belongs to " lump in the abdomen ", " gathering " category of the traditional Chinese medical science.The morbidity of ovarian cancer is due to positive QI-insufficiency, victory in pathogen, and causes.General evil in main righting gas of holding concurrently to attack at the initial stage of a disease; The positive deficiency of vital energy then main manifestations is deficiency of both QI and YIN.Stage take righting as main holding concurrently except pathogen.Pathogen mainly contains qi depression to blood stasis, and noxious dampness stops up Sheng two type.
Publication No. CN104383464A(application number 201410757554.6) Chinese patent literature disclose a kind of Chinese medicine composition for the treatment of ovarian cancer, belong to technical field of Chinese medicines, be prepared from by following raw material: the Rhizoma Pinelliae, Rhizoma Curcumae, the Rhizoma Atractylodis Macrocephalae, Myrrha, the Cortex Eucommiae, Semen Armeniacae Amarum, Radix Paeoniae Rubra, Radix Polygalae, Rhizoma Alismatis, Radix Dipsaci, Rhizoma Corydalis, Pheretima, the Radix Aucklandiae, Radix Codonopsis, Radix Curcumae, Herba Asari, Radix Bupleuri, Radix Angelicae Sinensis, Herba Taxilli, Radix Ginseng, Squama Manis, Radix Ophiopogonis, Radix Rehmanniae Preparata, Radix Angelicae Pubescentis, the Radix Astragali, Fructus Ligustri Lucidi, Semen Plantaginis, Spica Prunellae, Rhizoma Chuanxiong.Publication No. CN103977347A(application number 201410191927.8) Chinese patent literature disclose a kind of Chinese medicine for the treatment of ovarian cancer, comprise Rhizoma Sparganii, Rhizoma Curcumae, Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra, Fructus Toosendan, Herba Salviae Chinensis, Rhizoma Corydalis, the Radix Linderae, the Radix Astragali, Endothelium Corneum Gigeriae Galli, Pollen Typhae, Radix Notoginseng, fries Endothelium corneum and JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata).Publication No. CN102423369A(application number 201110449211.X) Chinese patent literature disclose a kind of prevention or treatment ovarian cancer Chinese medicine composition, relate to technical field of Chinese medicine.It is formed by the active fraction preparation of following weight portion: Cortex Phellodendri 10-15 part, Fructus Arctii 10-15 part, Fructus Forsythiae 15-20 part, Herba Taraxaci 15-18 part, Rhizoma Chuanxiong 12-16 part, Ramulus Cinnamomi 12-16 part, Radix Et Rhizoma Rhei 10-15 part, Radix Rehmanniae 14-18 part, Hirudo 6-10 part.
The main method for the treatment of ovarian cancer is based on the Comprehensive Treatment of operation, chemotherapy, some patients can select to add with radiotherapy, though lump can be removed fast, but relapse rate is high, injury is large, and Chinese Medicine and Clavicular treatment can improve conditions of patients, enhancing immunity, reduce painful, improving life quality, is a kind of therapeutic modality reliably.
Summary of the invention
For the problem of prior art, the object of this invention is to provide a kind of Be very effective, take Chinese medicine composition and the method for making of the wide treatment ovarian cancer of safe and applicable.
Technical scheme of the present invention is:
Cure a Chinese medicine composition for ovarian cancer, be prepared from primarily of following bulk drugs, be mass parts: Fructus Galangae 6-9; Herba Lespedezae Cuneatae 9-15; Radix Actinidiae Erianthae root 10-14; Radix eriosematis chinensis 8-13; Poria 9-16; Radix Flemingiae Philippinensis 7-14; Lignum Dalbergiae Odoriferae 6-12; Herba Aletridis Khasianae 9-15; Herba Saginae Japonicae 7-16; Fructus Vaccinii Bracteati 8-14; Caulis et Folium Fici beecheyanae 10-15; Fructus Lycii 9-14; Radix cynanchi wallichii 7-15; Folium Linderae strychnifoliae 9-12.
Preferred version is, Fructus Galangae 7-8; Herba Lespedezae Cuneatae 10-14; Radix Actinidiae Erianthae root 11-13; Radix eriosematis chinensis 9-12; Poria 11-14; Radix Flemingiae Philippinensis 9-12; Lignum Dalbergiae Odoriferae 8-10; Herba Aletridis Khasianae 11-13; Herba Saginae Japonicae 9-14; Fructus Vaccinii Bracteati 10-12; Caulis et Folium Fici beecheyanae 11-14; Fructus Lycii 11-12; Radix cynanchi wallichii 9-13; Folium Linderae strychnifoliae 10-11.
More preferably, Fructus Galangae 7.5; Herba Lespedezae Cuneatae 12; Radix Actinidiae Erianthae root 12; Radix eriosematis chinensis 10.5; Poria 12.5; Radix Flemingiae Philippinensis 10.5; Lignum Dalbergiae Odoriferae 9; Herba Aletridis Khasianae 12; Herba Saginae Japonicae 11.5; Fructus Vaccinii Bracteati 11; Caulis et Folium Fici beecheyanae 12.5; Fructus Lycii 11.5; Radix cynanchi wallichii 11; Folium Linderae strychnifoliae 10.5.
Described a kind of Chinese medicine composition of curing ovarian cancer, be made into pharmaceutically acceptable soft extract, its preparation method is:
(1) get Fructus Galangae, Fructus Vaccinii Bracteati and Fructus Lycii remove impurity to clean, wrap up three layers with toilet paper, drench and infiltrate 15-25 minute (preferably: infiltrate 18-22 minute into rice wine; Be more preferably: infiltrate 20 minutes), take out, be placed in fiery ash, simmer to toilet paper zoom black, taking-up cools, removing toilet paper;
(2) get Poria, Herba Aletridis Khasianae, Herba Saginae Japonicae, Caulis et Folium Fici beecheyanae and Folium Linderae strychnifoliae and clean remove impurity, add Rhizoma Zingiberis Recens juice to mix thoroughly, be placed in frying pan, add crude drug quality 0.3-0.5 Sal doubly and stir-fry (preferred: the Sal adding crude drug quality 0.4 times) together, moderate heat is fried and is turned yellow to crude drug surface, take out, cool;
(3) get Herba Lespedezae Cuneatae, Radix eriosematis chinensis, Radix Flemingiae Philippinensis and Radix cynanchi wallichii roguing to clean, be placed in boiling water leaching 5 minutes, take out cutting, mix thoroughly with rice (mass ratio of rice and crude drug is 1:5), put into marmite, drench into rice vinegar, stir-fry yellow to rice zoom, take out, remove rice;
(4) by Radix Actinidiae Erianthae root and Lignum Dalbergiae Odoriferae removing impurity, soak 15 minutes, take out and be placed in non iron container together with step (1) (2) (3) made crude drug, add decocting in water extremely boiling, turn little fire and decoct 22-32 minute (preferably: turn little fire and decoct 24-30 minute; Be more preferably: turn little fire and decoct 27 minutes), after filtration, collect filtrate, filtering residue adds water and again decocts, and merges twice gained filtrate;
(5) heat concentration step (4) gained mixed liquor to clear paste, add adjuvant refined honey, stir, obtain soft extract.
Described a kind of preparation method curing the Chinese medicine composition soft extract of ovarian cancer, the 5-7 that step (4) amount of water is boiled crude drug quality is (preferred: amount of water is 6 times of boiled crude drug quality) doubly.
Described a kind of Chinese medicine composition of curing ovarian cancer, be made into pharmaceutically acceptable powder, its preparation method is:
(1) get Fructus Galangae, Fructus Vaccinii Bracteati and Fructus Lycii remove impurity to clean, wrap up three layers with toilet paper, drench and infiltrate 15-25 minute (preferably: infiltrate 18-22 minute into rice wine; Be more preferably: infiltrate 20 minutes), take out, be placed in fiery ash, simmer to toilet paper zoom black, taking-up cools, removing toilet paper;
(2) get Poria, Herba Aletridis Khasianae, Herba Saginae Japonicae, Caulis et Folium Fici beecheyanae and Folium Linderae strychnifoliae and clean remove impurity, add Rhizoma Zingiberis Recens juice to mix thoroughly, be placed in frying pan, add crude drug quality 0.3-0.5 Sal doubly and stir-fry (preferred: the Sal adding crude drug quality 0.4 times) together, moderate heat is fried and is turned yellow to crude drug surface, take out, cool;
(3) get Herba Lespedezae Cuneatae, Radix eriosematis chinensis, Radix Flemingiae Philippinensis and Radix cynanchi wallichii roguing to clean, be placed in boiling water leaching 5 minutes, take out cutting, mix thoroughly with rice (mass ratio of rice and crude drug is 1:5), put into marmite, drench into rice vinegar, stir-fry yellow to rice zoom, take out, remove rice;
(4) by Radix Actinidiae Erianthae root and Lignum Dalbergiae Odoriferae removing impurity, soak 15 minutes, take out is placed in non iron container together with step (1) (2) (3) made crude drug, the decocting in water adding boiled crude drug quality 6 times, to boiling, turns little fire decoction 18-28 minute (preferred: to turn little fire and decoct 20-26 minute; Be more preferably: turn little fire and decoct 23 minutes), after filtration, collect filtrate, filtering residue adds water and again decocts, and merges twice gained filtrate;
(5) heat concentration step (4) gained mixed liquor to clear paste, oven dry pulverizes and sieves, and obtains powder.
Described a kind of preparation method curing the Chinese medicine powder of ovarian cancer, it is (preferred: to pulverize 160-200 mesh sieve that step (5) pulverized 120-240 mesh sieve; Be more preferably: pulverized 180 mesh sieves).
Described a kind of Chinese medicine composition of curing ovarian cancer, be made into pharmaceutically acceptable tablet, its preparation method is:
(1) get Fructus Galangae, Fructus Vaccinii Bracteati and Fructus Lycii remove impurity to clean, wrap up three layers with toilet paper, drench and infiltrate 15-25 minute (preferably: infiltrate 18-22 minute into rice wine; Be more preferably: infiltrate 20 minutes), take out, be placed in fiery ash, simmer to toilet paper zoom black, taking-up cools, removing toilet paper;
(2) get Poria, Herba Aletridis Khasianae, Herba Saginae Japonicae, Caulis et Folium Fici beecheyanae and Folium Linderae strychnifoliae and clean remove impurity, add Rhizoma Zingiberis Recens juice to mix thoroughly, be placed in frying pan, add crude drug quality 0.3-0.5 Sal doubly and stir-fry (preferred: the Sal adding crude drug quality 0.4 times) together, moderate heat is fried and is turned yellow to crude drug surface, take out, cool;
(3) get Herba Lespedezae Cuneatae, Radix eriosematis chinensis, Radix Flemingiae Philippinensis and Radix cynanchi wallichii roguing to clean, be placed in boiling water leaching 5 minutes, take out cutting, mix thoroughly with rice (mass ratio of rice and crude drug is 1:5), put into marmite, drench into rice vinegar, stir-fry yellow to rice zoom, take out, remove rice;
(4) by Radix Actinidiae Erianthae root and Lignum Dalbergiae Odoriferae removing impurity, soak 15 minutes, take out is placed in non iron container together with step (1) (2) (3) made crude drug, the decocting in water adding boiled crude drug quality 6 times, to boiling, turns little fire decoction 18-28 minute (preferred: to turn little fire and decoct 20-26 minute; Be more preferably: turn little fire and decoct 23 minutes), after filtration, collect filtrate, filtering residue adds water and again decocts, and merges twice gained filtrate;
(5) spray drying step (4) gained mixed liquor, pulverizes and makes medicated powder, be pressed into round sheet dosage form, obtain tablet according to the preparation method of tablet.
Described a kind of preparation method curing the Chinese medicine composition tablet of ovarian cancer, the weight of step (5) tablet is 0.3-0.5g/ sheet (preferred: the weight of tablet is 0.4g/ sheet).
Described a kind of Chinese medicine composition of curing ovarian cancer, be made into pharmaceutically acceptable decoction, its preparation method is:
(1) get Fructus Galangae, Fructus Vaccinii Bracteati and Fructus Lycii remove impurity to clean, wrap up three layers with toilet paper, drench and infiltrate 15-25 minute (preferably: infiltrate 18-22 minute into rice wine; Be more preferably: infiltrate 20 minutes), take out, be placed in fiery ash, simmer to toilet paper zoom black, taking-up cools, removing toilet paper;
(2) get Poria, Herba Aletridis Khasianae, Herba Saginae Japonicae, Caulis et Folium Fici beecheyanae and Folium Linderae strychnifoliae and clean remove impurity, add Rhizoma Zingiberis Recens juice to mix thoroughly, be placed in frying pan, add crude drug quality 0.3-0.5 Sal doubly and stir-fry (preferred: the Sal adding crude drug quality 0.4 times) together, moderate heat is fried and is turned yellow to crude drug surface, take out, cool;
(3) get Herba Lespedezae Cuneatae, Radix eriosematis chinensis, Radix Flemingiae Philippinensis and Radix cynanchi wallichii roguing to clean, be placed in boiling water leaching 5 minutes, take out cutting, mix thoroughly with rice (mass ratio of rice and crude drug is 1:5), put into marmite, drench into rice vinegar, stir-fry yellow to rice zoom, take out, remove rice;
(4) by Radix Actinidiae Erianthae root and Lignum Dalbergiae Odoriferae removing impurity, soak 15 minutes, take out and be placed in non iron container together with step (1) (2) (3) made crude drug, add decocting in water extremely boiling, turn little fire and decoct 22-32 minute (preferably: turn little fire and decoct 24-30 minute; Be more preferably: turn little fire and decoct 27 minutes), after filtration, collect filtrate, filtering residue adds water and again decocts, and merges twice gained filtrate, obtains decoction.
Described a kind of preparation method curing the Chinese medicine composition decoction of ovarian cancer, the 6-9 that step (4) amount of water is boiled crude drug quality is doubly (preferred: the 7-8 that amount of water is boiled crude drug quality is doubly; Be more preferably: amount of water is 7.5 times of boiled crude drug quality).
The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:
Fructus Galangae: base is former: be the fruit of zingiberaceous plant Rhizoma Alpiniae Galangae.Nature and flavor: acrid in the mouth; Warm in nature.Gui Jing: spleen; Lung meridian.Function cures mainly: warming middle-JIAO dampness; Be amusing and help digestion.Main coldness and pain in the epigastrium; Dyspeptic abdominal distention, vomiting is had loose bowels; Dysphagia and regurgitation.
Herba Lespedezae Cuneatae: base is former: be herb or the root of leguminous plant Herba Lespedezae Cuneatae.Nature and flavor: bitter, puckery, cool.Gui Jing: lung; Liver; Kidney channel.Function cures mainly: the kidney invigorating arresting seminal emission; Invigorating spleen to remove dampness; Expelling phlegm for arresting cough; Heat-clearing and toxic substances removing.Master suffers from a deficiency of the kidney; Seminal emission; The enuresis; Frequent micturition; Nebulousurine; Leukorrhagia; Have loose bowels; Dysentery; Edema; Infantile malnutrition; Cough and asthma; Traumatic injury; Conjunctival congestion and swelling pain; Carbuncle pyogenic infections from tumour or sore; Insect-bite.
Radix Actinidiae Erianthae root: base is former: be root and the root bark of Actinidiaceae plant actinidia eriantha.Nature and flavor: light; Micro-pungent; Cold.Function cures mainly: removing toxic substances and promoting subsidence of swelling; Clearing away heat-damp and promoting diuresis.Main pyretic toxicity carbuncle; Acute mastitis; Lung-heat aphonia; Hygropyretic dysentery; Stranguria with turbid discharge; Leukorrhagia; Rheumatic arthralgia; Gastric cancer; The esophageal carcinoma; Breast carcinoma; Traumatic injury.
Radix eriosematis chinensis: base is former: be the tuber of leguminous plant Radix eriosematis chinensis.Nature and flavor: sweet are flat.Gui Jing: lung; Large intestine; Liver Channel.Function cures mainly: removing heat from the lung and dissipating phlegm.Control cough due to lung-heat, excessive thirst, dysentery.
Poria: base is former: be the dry sclerotia of Polyporaceae plant Poria.Nature and flavor with return through: sweet, light, flat.GUIXIN, lung, spleen, kidney channel.There is promoting diuresis to eliminate damp pathogen, spleen invigorating, effect of mind calming.For edema oliguria, phlegm retention vertigo and palpitation, insufficiency of the spleen lack of appetite, have loose bowels in loose stool, irritability, palpitation with fear insomnia.
Radix Flemingiae Philippinensis: base is former: be the root of leguminous plant Flemingia philippinensis.Nature and flavor: sweet; Puckery; Flat.Gui Jing: lung; Kidney; Urinary bladder channel.Function cures mainly: expelling wind and removing dampness; Bone and muscle strengthening; Promoting blood circulation and detoxication.Main air pain of dampness syndrome; Lumbar muscle strain; Extremity flaccidity is soft; Traumatic injury; Laryngopharynx swelling and pain.
Lignum Dalbergiae Odoriferae: base is former: be trunk or the root heartwood of leguminous plant Lignum Dalbergiae Odoriferae wingceltis, sissoo.Nature and flavor: pungent; Temperature; Nontoxic.Gui Jing: liver; Spleen; Lung; Heart channel.Function cures mainly: promoting blood circulation to remove blood stasis, and hemostasis analgesic therapy, sending down the abnormal ascending QI, wards off dirty.Main pain in chest and hypochondrium, traumatic injury, wound hemorrhage, and the vomiting stomachache of colic of cold type pain or foul internal resistance.
Herba Aletridis Khasianae: base is former: be the herb of liliaceous plant Honoka alertris spicata.Nature and flavor: hide pungent; Micro-hardship; Warm in nature.Gui Jing: lung; Liver Channel.Function cures mainly: tonify deficiency arresting sweating; Hemostasis.The empty hyperhidrosis of main body; Night sweat; Neurasthenia; Spit blood; Have blood in stool.
Herba Saginae Japonicae: base is former: be the herb of pinkwort Herba Saginae Japonicae.Nature and flavor: bitter; Pungent; Cool in nature.Gui Jing: liver; Stomach warp.Function cures mainly: removing pathogenic heat from blood and toxic substance from the body; Killing parasites for relieving itching.Main dermatitis rhus; Tinea alba; Eczema; Erysipelas; Scrofula; Innominate toxic swelling; Venom; Nasal sinusitis; Caries pain; Internal traumatic injury.
Fructus Vaccinii Bracteati: base is former: be the fruit of Ericaceae village thing Fructus Vaccinii Bracteati.Nature and flavor: acid; Sweet; Property is put down.Gui Jing: liver; Kidney; Liver Channel.Function cures mainly: invigorating the liver and kidney; Bone and muscle strengthening; Controlling nocturnal emission with astringent drugs gas; Antidiarrheal dysentery.Main deficiency of the liver and kindey; Early whitening of beard and hair; Muscles and bones is unable; Chronic diarrhea nocturnal emission; Leukorrhagia is more than; The outer dysentery of chronic diarrhea.
Caulis et Folium Fici beecheyanae: base is former: be stem, the leaf of moraceae plants Fructus Fici Beecheyanae.Nature and flavor: sweet; Light; Warm in nature.Gui Jing: lung; Spleen; Kidney channel.Function cures mainly: invigorating middle warmer spleen invigorating; Wind-damp dispelling; Promoting blood circulation to remove obstruction in the collateral.The main deficiency of vital energy is weak; Extremity are aching and limp; Rheumatic arthralgia; Stiffness of the muscle and joint; Traumatic injury; Amenorrhea; Galactostasis.
Fructus Lycii: base is former: be the mature fruit of matrimony vine of solanaceae plant or lycium barbarum.Chemical analysis: containing carotene 3.39 milligrams of %, thiamine 0.23 milligram of %, riboflavin 0.33 milligram of %, nicotinic acid 1.7 milligrams of %, ascorbic acid 3 milligrams of % in Fructus Lycii.Still isolate cupreol, linoleic acid.Nature and flavor: sweet are flat.Gui Jing: enter liver, kidney channel.Function cures mainly: nourishing kidney, lung moistening, tonifying liver, improving eyesight.Control hepatic and renal YIN deficiency, soreness of the waist and knees, dizzy, dizzy, the many tear of blurred vision, cough due to consumptive disease, quenches one's thirst, seminal emission.
Radix cynanchi wallichii: base is former: be the root of dicotyledon Yao Luo section plant Cynanchum Wallichii.Nature and flavor: sweet; Micro-hardship; Temperature.Gui Jing: liver; Kidney channel.Function cures mainly: invigorating the liver and kidney; Bone and muscle strengthening.Main lumbago due to renal deficiency; The foot and knee being feeble; Traumatic injury damages appoints; Fracture; Lyssodexis.
Folium Linderae strychnifoliae: base is former: be the leaf of the canella Radix Linderae.Nature and flavor: pungent; Temperature.Gui Jing: spleen; Kidney channel.Function cures mainly: warming middle-JIAO is regulated the flow of vital energy; Reducing swelling and alleviating pain.Main coldness and pain in the epigastrium; Frequent micturition; Rheumatic arthralgia; Traumatic pain; Scald.
A kind of Traditional Chinese medicine composition formula science curing ovarian cancer provided by the invention, preparation method is simple.In addition, its excellent part also shows:
1, products obtained therefrom of the present invention, therapeutic effect is good, and cure rate is high, effectively can reduce relapse rate;
2, this formula is summed up through clinical practice for many years and is formed, and has effect of removing toxic substances pain relieving, kidney and spleen invigorating;
3, Chinese crude drug selected by the present invention, safety has no side effect, can long-term taking, can regulate patient body function.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited thereto.
embodiment 1cure a Chinese medicine composition for ovarian cancer, be prepared from (every part of 10g) primarily of following bulk drugs: Fructus Galangae 6 parts, Herba Lespedezae Cuneatae 9 parts, Radix Actinidiae Erianthae root 10 parts, Radix eriosematis chinensis 8 parts, 9 parts, Poria, Radix Flemingiae Philippinensis 7 parts, Lignum Dalbergiae Odoriferae 6 parts, Herba Aletridis Khasianae 9 parts, Herba Saginae Japonicae 7 parts, Fructus Vaccinii Bracteati 8 parts, Caulis et Folium Fici beecheyanae 10 parts, Fructus Lycii 9 parts, Radix cynanchi wallichii 7 parts, Folium Linderae strychnifoliae 9 parts.Above-mentioned a kind of preparation method curing the Chinese medicine composition soft extract of ovarian cancer is:
(1) get Fructus Galangae, Fructus Vaccinii Bracteati and Fructus Lycii remove impurity to clean, wrap up three layers, drench and infiltrate 20 minutes into rice wine with toilet paper, take out, be placed in fiery ash, simmer to toilet paper zoom black, taking-up cools, removing toilet paper;
(2) get Poria, Herba Aletridis Khasianae, Herba Saginae Japonicae, Caulis et Folium Fici beecheyanae and Folium Linderae strychnifoliae and clean remove impurity, add Rhizoma Zingiberis Recens juice and mix thoroughly, be placed in frying pan, the Sal adding crude drug quality 0.4 times stir-fries together, and moderate heat is fried and turned yellow to crude drug surface, takes out, cools;
(3) get Herba Lespedezae Cuneatae, Radix eriosematis chinensis, Radix Flemingiae Philippinensis and Radix cynanchi wallichii roguing to clean, be placed in boiling water leaching 5 minutes, take out cutting, mix thoroughly with rice (mass ratio of rice and crude drug is 1:5), put into marmite, drench into rice vinegar, stir-fry yellow to rice zoom, take out, remove rice;
(4) by Radix Actinidiae Erianthae root and Lignum Dalbergiae Odoriferae removing impurity, soak 15 minutes, take out is placed in non iron container together with step (1) (2) (3) made crude drug, add the decocting in water of boiled crude drug quality 6 times to boiling, turn little fire to decoct 27 minutes, after filtration, collect filtrate, filtering residue adds water and again decocts, and merges twice gained filtrate;
(5) heat concentration step (4) gained mixed liquor to clear paste, add adjuvant refined honey, stir, obtain soft extract.
embodiment 2cure a Chinese medicine composition for ovarian cancer, be prepared from (every part of 10g) primarily of following bulk drugs: Fructus Galangae 9 parts, Herba Lespedezae Cuneatae 15 parts, Radix Actinidiae Erianthae root 14 parts, Radix eriosematis chinensis 13 parts, 16 parts, Poria, Radix Flemingiae Philippinensis 14 parts, Lignum Dalbergiae Odoriferae 12 parts, Herba Aletridis Khasianae 15 parts, Herba Saginae Japonicae 16 parts, Fructus Vaccinii Bracteati 14 parts, Caulis et Folium Fici beecheyanae 15 parts, Fructus Lycii 14 parts, Radix cynanchi wallichii 15 parts, Folium Linderae strychnifoliae 12 parts.Above-mentioned a kind of preparation method curing the Chinese medicine powder of ovarian cancer is:
(1) get Fructus Galangae, Fructus Vaccinii Bracteati and Fructus Lycii remove impurity to clean, wrap up three layers, drench and infiltrate 20 minutes into rice wine with toilet paper, take out, be placed in fiery ash, simmer to toilet paper zoom black, taking-up cools, removing toilet paper;
(2) get Poria, Herba Aletridis Khasianae, Herba Saginae Japonicae, Caulis et Folium Fici beecheyanae and Folium Linderae strychnifoliae and clean remove impurity, add Rhizoma Zingiberis Recens juice and mix thoroughly, be placed in frying pan, the Sal adding crude drug quality 0.4 times stir-fries together, and moderate heat is fried and turned yellow to crude drug surface, takes out, cools;
(3) get Herba Lespedezae Cuneatae, Radix eriosematis chinensis, Radix Flemingiae Philippinensis and Radix cynanchi wallichii roguing to clean, be placed in boiling water leaching 5 minutes, take out cutting, mix thoroughly with rice (mass ratio of rice and crude drug is 1:5), put into marmite, drench into rice vinegar, stir-fry yellow to rice zoom, take out, remove rice;
(4) by Radix Actinidiae Erianthae root and Lignum Dalbergiae Odoriferae removing impurity, soak 15 minutes, take out is placed in non iron container together with step (1) (2) (3) made crude drug, add the decocting in water of boiled crude drug quality 6 times to boiling, turn little fire to decoct 23 minutes, after filtration, collect filtrate, filtering residue adds water and again decocts, and merges twice gained filtrate;
(5) heat concentration step (4) gained mixed liquor to clear paste, dry and pulverized 180 mesh sieves, obtain powder.
Model case: xxx, women, 41 years old.Check out ovarian cancer during patient's health check-up, after treating two courses for the treatment of, occur untoward reaction by chemotherapy means, nausea and vomiting is serious, weight loss, and the mental status is not good, then stops chemotherapy, uses the treatment of prescription method instead.
Take this example gained powder, each 3-4g, warm boiled water, one day twice, within 30 days, be a course for the treatment of, after patient takes a course for the treatment of, uncomfortable disease obviously alleviates, spirit and muscle power increase, after adhering to taking four courses for the treatment of, patient's cancerous cell is eliminated substantially, physical recovery, follow up a case by regular visits in two years, the state of an illness does not recur.
embodiment 3cure a Chinese medicine composition for ovarian cancer, be prepared from (every part of 10g) primarily of following bulk drugs: Fructus Galangae 7 parts, Herba Lespedezae Cuneatae 10 parts, Radix Actinidiae Erianthae root 11 parts, Radix eriosematis chinensis 9 parts, 11 parts, Poria, Radix Flemingiae Philippinensis 9 parts, Lignum Dalbergiae Odoriferae 8 parts, Herba Aletridis Khasianae 11 parts, Herba Saginae Japonicae 9 parts, Fructus Vaccinii Bracteati 10 parts, Caulis et Folium Fici beecheyanae 11 parts, Fructus Lycii 11 parts, Radix cynanchi wallichii 9 parts, Folium Linderae strychnifoliae 10 parts.Above-mentioned a kind of preparation method curing the Chinese medicine composition tablet of ovarian cancer is:
(1) get Fructus Galangae, Fructus Vaccinii Bracteati and Fructus Lycii remove impurity to clean, wrap up three layers, drench and infiltrate 20 minutes into rice wine with toilet paper, take out, be placed in fiery ash, simmer to toilet paper zoom black, taking-up cools, removing toilet paper;
(2) get Poria, Herba Aletridis Khasianae, Herba Saginae Japonicae, Caulis et Folium Fici beecheyanae and Folium Linderae strychnifoliae and clean remove impurity, add Rhizoma Zingiberis Recens juice and mix thoroughly, be placed in frying pan, the Sal adding crude drug quality 0.4 times stir-fries together, and moderate heat is fried and turned yellow to crude drug surface, takes out, cools;
(3) get Herba Lespedezae Cuneatae, Radix eriosematis chinensis, Radix Flemingiae Philippinensis and Radix cynanchi wallichii roguing to clean, be placed in boiling water leaching 5 minutes, take out cutting, mix thoroughly with rice (mass ratio of rice and crude drug is 1:5), put into marmite, drench into rice vinegar, stir-fry yellow to rice zoom, take out, remove rice;
(4) by Radix Actinidiae Erianthae root and Lignum Dalbergiae Odoriferae removing impurity, soak 15 minutes, take out is placed in non iron container together with step (1) (2) (3) made crude drug, add the decocting in water of boiled crude drug quality 6 times to boiling, turn little fire to decoct 23 minutes, after filtration, collect filtrate, filtering residue adds water and again decocts, and merges twice gained filtrate;
(5) spray drying step (4) gained mixed liquor, pulverizes and makes medicated powder, be pressed into round sheet dosage form, obtain tablet (weight is 0.4g/ sheet) according to the preparation method of tablet.
Model case: xxx, women, 53 years old.Patient, because of stomachache, menoxenia and have irregular bleeding symptom to remove examination in hospital, is shown as ovarian tumor through B ultrasonic, is diagnosed as the ovarian cancer III phase further, and after underwent operative excision, patient, because of economic cause, selects to go home expectant treatment.
Recommend to take this example gained tablet, each 3-4 sheet, warm boiled water through people, one day twice 30 days is a course for the treatment of, after patient takes a course for the treatment of, postoperative wound obviously recovers, uncomfortable disease is eliminated gradually, and after adhering to taking three courses for the treatment of, tumor does not spread, continue to strengthen again two courses for the treatment of, patient's drug withdrawal, follow up a case by regular visits in 3 years, patient is still survived.
embodiment 4cure a Chinese medicine composition for ovarian cancer, be prepared from (every part of 10g) primarily of following bulk drugs: Fructus Galangae 8 parts, Herba Lespedezae Cuneatae 14 parts, Radix Actinidiae Erianthae root 13 parts, Radix eriosematis chinensis 12 parts, 14 parts, Poria, Radix Flemingiae Philippinensis 12 parts, Lignum Dalbergiae Odoriferae 10 parts, Herba Aletridis Khasianae 13 parts, Herba Saginae Japonicae 14 parts, Fructus Vaccinii Bracteati 12 parts, Caulis et Folium Fici beecheyanae 14 parts, Fructus Lycii 12 parts, Radix cynanchi wallichii 13 parts, Folium Linderae strychnifoliae 11 parts.Above-mentioned a kind of preparation method curing the Chinese medicine composition decoction of ovarian cancer is:
(1) get Fructus Galangae, Fructus Vaccinii Bracteati and Fructus Lycii remove impurity to clean, wrap up three layers, drench and infiltrate 20 minutes into rice wine with toilet paper, take out, be placed in fiery ash, simmer to toilet paper zoom black, taking-up cools, removing toilet paper;
(2) get Poria, Herba Aletridis Khasianae, Herba Saginae Japonicae, Caulis et Folium Fici beecheyanae and Folium Linderae strychnifoliae and clean remove impurity, add Rhizoma Zingiberis Recens juice and mix thoroughly, be placed in frying pan, the Sal adding crude drug quality 0.4 times stir-fries together, and moderate heat is fried and turned yellow to crude drug surface, takes out, cools;
(3) get Herba Lespedezae Cuneatae, Radix eriosematis chinensis, Radix Flemingiae Philippinensis and Radix cynanchi wallichii roguing to clean, be placed in boiling water leaching 5 minutes, take out cutting, mix thoroughly with rice (mass ratio of rice and crude drug is 1:5), put into marmite, drench into rice vinegar, stir-fry yellow to rice zoom, take out, remove rice;
(4) by Radix Actinidiae Erianthae root and Lignum Dalbergiae Odoriferae removing impurity, soak 15 minutes, take out is placed in non iron container together with step (1) (2) (3) made crude drug, the decocting in water adding boiled crude drug quality 7.5 times, to boiling, turns little fire and decocts 27 minutes, after filtration, collect filtrate, filtering residue adds water and again decocts, and merges twice gained filtrate, obtains decoction.
Model case: xxx, women, 45 years old.Main suit: abdominal part distending pain, stool has some setbacks, menoxenia half a year; Medical history: before patient half a year, health occurs uncomfortable without obvious inducement, abdominal part distending pain, and menstruation irregularis, to examination in hospital, CT shows ovary lump, and about baby's fist size, through diagnosing further, is defined as ovarian cancer.
Patient, while chemotherapy, takes this example gained decoction, each 250-350ml, warmly take, one day twice 30 days is a course for the treatment of, after patient takes a course for the treatment of, muscle power and the mental status are clearly better, and continue to take three courses for the treatment of, uncomfortable disease all disappears, reexamine focus is eliminated substantially, and after drug withdrawal, patient recovers orthobiosis, follow up a case by regular visits to after 3 years, patient is not recurred.
embodiment 5cure a Chinese medicine composition for ovarian cancer, be prepared from (every part of 10g) primarily of following bulk drugs: Fructus Galangae 7.5 parts, Herba Lespedezae Cuneatae 12 parts, Radix Actinidiae Erianthae root 12 parts, Radix eriosematis chinensis 10.5 parts, 12.5 parts, Poria, Radix Flemingiae Philippinensis 10.5 parts, Lignum Dalbergiae Odoriferae 9 parts, Herba Aletridis Khasianae 12 parts, Herba Saginae Japonicae 11.5 parts, Fructus Vaccinii Bracteati 11 parts, Caulis et Folium Fici beecheyanae 12.5 parts, Fructus Lycii 11.5 parts, Radix cynanchi wallichii 11 parts, Folium Linderae strychnifoliae 10.5 parts.Above-mentioned a kind of preparation method curing the Chinese medicine composition soft extract of ovarian cancer is:
(1) get Fructus Galangae, Fructus Vaccinii Bracteati and Fructus Lycii remove impurity to clean, wrap up three layers, drench and infiltrate 20 minutes into rice wine with toilet paper, take out, be placed in fiery ash, simmer to toilet paper zoom black, taking-up cools, removing toilet paper;
(2) get Poria, Herba Aletridis Khasianae, Herba Saginae Japonicae, Caulis et Folium Fici beecheyanae and Folium Linderae strychnifoliae and clean remove impurity, add Rhizoma Zingiberis Recens juice and mix thoroughly, be placed in frying pan, the Sal adding crude drug quality 0.4 times stir-fries together, and moderate heat is fried and turned yellow to crude drug surface, takes out, cools;
(3) get Herba Lespedezae Cuneatae, Radix eriosematis chinensis, Radix Flemingiae Philippinensis and Radix cynanchi wallichii roguing to clean, be placed in boiling water leaching 5 minutes, take out cutting, mix thoroughly with rice (mass ratio of rice and crude drug is 1:5), put into marmite, drench into rice vinegar, stir-fry yellow to rice zoom, take out, remove rice;
(4) by Radix Actinidiae Erianthae root and Lignum Dalbergiae Odoriferae removing impurity, soak 15 minutes, take out is placed in non iron container together with step (1) (2) (3) made crude drug, add the decocting in water of boiled crude drug quality 6 times to boiling, turn little fire to decoct 27 minutes, after filtration, collect filtrate, filtering residue adds water and again decocts, and merges twice gained filtrate;
(5) heat concentration step (4) gained mixed liquor to clear paste, add adjuvant refined honey, stir, obtain soft extract.
test example 1a kind of clinical practice of curing the Chinese medicine composition (embodiment 5) of ovarian cancer of gained of the present invention:
Choose crowd: in August, 2013 in December ,-2014, according to medical case history, patient 352 example of ovarian cancer is had six hospital's screenings, age 32-65 year, 48.9 ± 2.7 years old mean age, the course of disease 0.5 year-5 years, wherein show as I phase patient 88 example clinically by stages, II phase patient 64 example, III phase patient 57 example, IV phase patient 143 example.
Before test, patient is divided into two groups at random, experimental group 200 example and matched group 152 routine, two groups in age, the course of disease, the state of an illness etc. without significant difference.Matched group adopts chemotherapy; Experimental group, on chemotherapeutical basis, takes products obtained therefrom of the present invention, each 6-10g, one day twice, warm boiled water, within 30 days, is a course for the treatment of.Treatments period carries out Continuous Observation to two groups of patients, record symptom and change.
Curative effect determinate standard: reference literature criterion of therapeutical effect, (1) complete incidence graph (CR): all pathological changes disappear completely and continue more than 4 weeks; (2) partial rcsponse (PR): tumor focus maximum perpendicular two footpath product reduces >=and 50%, and maintain more than 4 weeks; (3) stable (SD): tumor regression or increase be not all more than 50%; (4) be in progress (PD): tumor focus increases above 50%, or occurs new focus.Total effective rate=(CR+PR)/case load * 100%.
Clinical effectiveness: after the treatment of four courses for the treatment of, the therapeutic outcome of two groups is as shown in table 1:
As shown in Table 1, the total effective rate of experimental group is 81.5%, and the total effective rate 70.4% of matched group, be starkly lower than the therapeutic effect of experimental group, illustrate that products obtained therefrom of the present invention is evident in efficacy, cure rate is high.By contrasting recurrence number of cases and the side effect number of cases of two groups, known products obtained therefrom of the present invention is safer, without obvious toxic-side effects.
The Chinese medicine used in the present invention, Fructus Galangae warming middle-JIAO dampness, Herba Lespedezae Cuneatae the kidney invigorating arresting seminal emission, Radix Actinidiae Erianthae root removing toxic substances and promoting subsidence of swelling, Radix eriosematis chinensis removing heat from the lung and dissipating phlegm, Poria spleen invigorating mind calming, Radix Flemingiae Philippinensis promoting blood circulation and detoxication, Lignum Dalbergiae Odoriferae hemostasis analgesic therapy, Herba Aletridis Khasianae tonify deficiency arresting sweating, Herba Saginae Japonicae removing pathogenic heat from blood and toxic substance from the body, Fructus Vaccinii Bracteati, the strong muscle of Radix cynanchi wallichii the kidney invigorating, Caulis et Folium Fici beecheyanae invigorating middle warmer spleen invigorating, Fructus Lycii lung moistening tonifying liver, Folium Linderae strychnifoliae reducing swelling and alleviating pain, multiple medical material synergism, play effect of removing toxic substances pain relieving, kidney and spleen invigorating altogether, effectively eliminate cancerous cell, prevent diffusion.
It should be pointed out that detailed description of the invention is the more representational example of the present invention, obvious technical scheme of the present invention is not limited to above-described embodiment, can also have a lot of distortion.Those of ordinary skill in the art, with the present invention clear and definite disclosed or according to undoubted the obtaining of the written description of file, the claimed scope of this patent all should be thought.
Claims (10)
1. cure a Chinese medicine composition for ovarian cancer, it is characterized in that, be prepared from primarily of following bulk drugs, be mass parts: Fructus Galangae 6-9; Herba Lespedezae Cuneatae 9-15; Radix Actinidiae Erianthae root 10-14; Radix eriosematis chinensis 8-13; Poria 9-16; Radix Flemingiae Philippinensis 7-14; Lignum Dalbergiae Odoriferae 6-12; Herba Aletridis Khasianae 9-15; Herba Saginae Japonicae 7-16; Fructus Vaccinii Bracteati 8-14; Caulis et Folium Fici beecheyanae 10-15; Fructus Lycii 9-14; Radix cynanchi wallichii 7-15; Folium Linderae strychnifoliae 9-12.
2. a kind of Chinese medicine composition of curing ovarian cancer as claimed in claim 1, is characterized in that, Fructus Galangae 7-8; Herba Lespedezae Cuneatae 10-14; Radix Actinidiae Erianthae root 11-13; Radix eriosematis chinensis 9-12; Poria 11-14; Radix Flemingiae Philippinensis 9-12; Lignum Dalbergiae Odoriferae 8-10; Herba Aletridis Khasianae 11-13; Herba Saginae Japonicae 9-14; Fructus Vaccinii Bracteati 10-12; Caulis et Folium Fici beecheyanae 11-14; Fructus Lycii 11-12; Radix cynanchi wallichii 9-13; Folium Linderae strychnifoliae 10-11(is preferably: Fructus Galangae 7.5; Herba Lespedezae Cuneatae 12; Radix Actinidiae Erianthae root 12; Radix eriosematis chinensis 10.5; Poria 12.5; Radix Flemingiae Philippinensis 10.5; Lignum Dalbergiae Odoriferae 9; Herba Aletridis Khasianae 12; Herba Saginae Japonicae 11.5; Fructus Vaccinii Bracteati 11; Caulis et Folium Fici beecheyanae 12.5; Fructus Lycii 11.5; Radix cynanchi wallichii 11; Folium Linderae strychnifoliae 10.5).
3. a kind of Chinese medicine composition of curing ovarian cancer as described in as arbitrary in claim 1-2, it is characterized in that, be made into pharmaceutically acceptable soft extract, its preparation method is:
(1) get Fructus Galangae, Fructus Vaccinii Bracteati and Fructus Lycii remove impurity to clean, wrap up three layers with toilet paper, drench and infiltrate 15-25 minute (preferably: infiltrate 18-22 minute into rice wine; Be more preferably: infiltrate 20 minutes), take out, be placed in fiery ash, simmer to toilet paper zoom black, taking-up cools, removing toilet paper;
(2) get Poria, Herba Aletridis Khasianae, Herba Saginae Japonicae, Caulis et Folium Fici beecheyanae and Folium Linderae strychnifoliae and clean remove impurity, add Rhizoma Zingiberis Recens juice to mix thoroughly, be placed in frying pan, add crude drug quality 0.3-0.5 Sal doubly and stir-fry (preferred: the Sal adding crude drug quality 0.4 times) together, moderate heat is fried and is turned yellow to crude drug surface, take out, cool;
(3) get Herba Lespedezae Cuneatae, Radix eriosematis chinensis, Radix Flemingiae Philippinensis and Radix cynanchi wallichii roguing to clean, be placed in boiling water leaching 5 minutes, take out cutting, mix thoroughly with rice (mass ratio of rice and crude drug is 1:5), put into marmite, drench into rice vinegar, stir-fry yellow to rice zoom, take out, remove rice;
(4) by Radix Actinidiae Erianthae root and Lignum Dalbergiae Odoriferae removing impurity, soak 15 minutes, take out and be placed in non iron container together with step (1) (2) (3) made crude drug, add decocting in water extremely boiling, turn little fire and decoct 22-32 minute (preferably: turn little fire and decoct 24-30 minute; Be more preferably: turn little fire and decoct 27 minutes), after filtration, collect filtrate, filtering residue adds water and again decocts, and merges twice gained filtrate;
(5) heat concentration step (4) gained mixed liquor to clear paste, add adjuvant refined honey, stir, obtain soft extract.
4. a kind of preparation method curing the Chinese medicine composition soft extract of ovarian cancer as claimed in claim 3, is characterized in that, the 5-7 that step (4) amount of water is boiled crude drug quality is (preferred: amount of water is 6 times of boiled crude drug quality) doubly.
5. a kind of Chinese medicine composition of curing ovarian cancer as described in as arbitrary in claim 1-2, it is characterized in that, be made into pharmaceutically acceptable powder, its preparation method is:
(1) get Fructus Galangae, Fructus Vaccinii Bracteati and Fructus Lycii remove impurity to clean, wrap up three layers with toilet paper, drench and infiltrate 15-25 minute (preferably: infiltrate 18-22 minute into rice wine; Be more preferably: infiltrate 20 minutes), take out, be placed in fiery ash, simmer to toilet paper zoom black, taking-up cools, removing toilet paper;
(2) get Poria, Herba Aletridis Khasianae, Herba Saginae Japonicae, Caulis et Folium Fici beecheyanae and Folium Linderae strychnifoliae and clean remove impurity, add Rhizoma Zingiberis Recens juice to mix thoroughly, be placed in frying pan, add crude drug quality 0.3-0.5 Sal doubly and stir-fry (preferred: the Sal adding crude drug quality 0.4 times) together, moderate heat is fried and is turned yellow to crude drug surface, take out, cool;
(3) get Herba Lespedezae Cuneatae, Radix eriosematis chinensis, Radix Flemingiae Philippinensis and Radix cynanchi wallichii roguing to clean, be placed in boiling water leaching 5 minutes, take out cutting, mix thoroughly with rice (mass ratio of rice and crude drug is 1:5), put into marmite, drench into rice vinegar, stir-fry yellow to rice zoom, take out, remove rice;
(4) by Radix Actinidiae Erianthae root and Lignum Dalbergiae Odoriferae removing impurity, soak 15 minutes, take out is placed in non iron container together with step (1) (2) (3) made crude drug, the decocting in water adding boiled crude drug quality 6 times, to boiling, turns little fire decoction 18-28 minute (preferred: to turn little fire and decoct 20-26 minute; Be more preferably: turn little fire and decoct 23 minutes), after filtration, collect filtrate, filtering residue adds water and again decocts, and merges twice gained filtrate;
(5) heat concentration step (4) gained mixed liquor to clear paste, oven dry pulverizes and sieves, and obtains powder.
6. a kind of preparation method curing the Chinese medicine powder of ovarian cancer as claimed in claim 5, is characterized in that, it is (preferred: to pulverize 160-200 mesh sieve that step (5) pulverized 120-240 mesh sieve; Be more preferably: pulverized 180 mesh sieves).
7. a kind of Chinese medicine composition of curing ovarian cancer as described in as arbitrary in claim 1-2, it is characterized in that, be made into pharmaceutically acceptable tablet, its preparation method is:
(1) get Fructus Galangae, Fructus Vaccinii Bracteati and Fructus Lycii remove impurity to clean, wrap up three layers with toilet paper, drench and infiltrate 15-25 minute (preferably: infiltrate 18-22 minute into rice wine; Be more preferably: infiltrate 20 minutes), take out, be placed in fiery ash, simmer to toilet paper zoom black, taking-up cools, removing toilet paper;
(2) get Poria, Herba Aletridis Khasianae, Herba Saginae Japonicae, Caulis et Folium Fici beecheyanae and Folium Linderae strychnifoliae and clean remove impurity, add Rhizoma Zingiberis Recens juice to mix thoroughly, be placed in frying pan, add crude drug quality 0.3-0.5 Sal doubly and stir-fry (preferred: the Sal adding crude drug quality 0.4 times) together, moderate heat is fried and is turned yellow to crude drug surface, take out, cool;
(3) get Herba Lespedezae Cuneatae, Radix eriosematis chinensis, Radix Flemingiae Philippinensis and Radix cynanchi wallichii roguing to clean, be placed in boiling water leaching 5 minutes, take out cutting, mix thoroughly with rice (mass ratio of rice and crude drug is 1:5), put into marmite, drench into rice vinegar, stir-fry yellow to rice zoom, take out, remove rice;
(4) by Radix Actinidiae Erianthae root and Lignum Dalbergiae Odoriferae removing impurity, soak 15 minutes, take out is placed in non iron container together with step (1) (2) (3) made crude drug, the decocting in water adding boiled crude drug quality 6 times, to boiling, turns little fire decoction 18-28 minute (preferred: to turn little fire and decoct 20-26 minute; Be more preferably: turn little fire and decoct 23 minutes), after filtration, collect filtrate, filtering residue adds water and again decocts, and merges twice gained filtrate;
(5) spray drying step (4) gained mixed liquor, pulverizes and makes medicated powder, be pressed into round sheet dosage form, obtain tablet according to the preparation method of tablet.
8. a kind of preparation method curing the Chinese medicine composition tablet of ovarian cancer as claimed in claim 7, is characterized in that, the weight of step (5) tablet is 0.3-0.5g/ sheet (preferred: the weight of tablet is 0.4g/ sheet).
9. a kind of Chinese medicine composition of curing ovarian cancer as described in as arbitrary in claim 1-2, it is characterized in that, be made into pharmaceutically acceptable decoction, its preparation method is:
(1) get Fructus Galangae, Fructus Vaccinii Bracteati and Fructus Lycii remove impurity to clean, wrap up three layers with toilet paper, drench and infiltrate 15-25 minute (preferably: infiltrate 18-22 minute into rice wine; Be more preferably: infiltrate 20 minutes), take out, be placed in fiery ash, simmer to toilet paper zoom black, taking-up cools, removing toilet paper;
(2) get Poria, Herba Aletridis Khasianae, Herba Saginae Japonicae, Caulis et Folium Fici beecheyanae and Folium Linderae strychnifoliae and clean remove impurity, add Rhizoma Zingiberis Recens juice to mix thoroughly, be placed in frying pan, add crude drug quality 0.3-0.5 Sal doubly and stir-fry (preferred: the Sal adding crude drug quality 0.4 times) together, moderate heat is fried and is turned yellow to crude drug surface, take out, cool;
(3) get Herba Lespedezae Cuneatae, Radix eriosematis chinensis, Radix Flemingiae Philippinensis and Radix cynanchi wallichii roguing to clean, be placed in boiling water leaching 5 minutes, take out cutting, mix thoroughly with rice (mass ratio of rice and crude drug is 1:5), put into marmite, drench into rice vinegar, stir-fry yellow to rice zoom, take out, remove rice;
(4) by Radix Actinidiae Erianthae root and Lignum Dalbergiae Odoriferae removing impurity, soak 15 minutes, take out and be placed in non iron container together with step (1) (2) (3) made crude drug, add decocting in water extremely boiling, turn little fire and decoct 22-32 minute (preferably: turn little fire and decoct 24-30 minute; Be more preferably: turn little fire and decoct 27 minutes), after filtration, collect filtrate, filtering residue adds water and again decocts, and merges twice gained filtrate, obtains decoction.
10. a kind of preparation method curing the Chinese medicine composition decoction of ovarian cancer as claimed in claim 9, is characterized in that, the 6-9 that step (4) amount of water is boiled crude drug quality is doubly (preferred: the 7-8 that amount of water is boiled crude drug quality doubly; Be more preferably: amount of water is 7.5 times of boiled crude drug quality).
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| KR20110058041A (en) * | 2009-11-25 | 2011-06-01 | 주식회사한국신약 | Health functional foods compositions for the prevention and amelioration of cancer containing the mixed extract of phellinus linteus mycelium and cultured panax ginseng cameyer as an active ingredient |
| CN102670944A (en) * | 2011-03-11 | 2012-09-19 | 上海中医药大学附属曙光医院 | Traditional Chinese medicine compound preparation for treating ovarian cancer and preparation method of traditional Chinese medicine compound preparation |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20110058041A (en) * | 2009-11-25 | 2011-06-01 | 주식회사한국신약 | Health functional foods compositions for the prevention and amelioration of cancer containing the mixed extract of phellinus linteus mycelium and cultured panax ginseng cameyer as an active ingredient |
| CN102670944A (en) * | 2011-03-11 | 2012-09-19 | 上海中医药大学附属曙光医院 | Traditional Chinese medicine compound preparation for treating ovarian cancer and preparation method of traditional Chinese medicine compound preparation |
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| Title |
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| 刘沈林等: "《现代中医临床手册》", 30 June 2001, 江苏科学技术出版社 * |
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Address after: 741000 Gansu province Tianshui District Road No. 37 Building No. 2 min 1-302 Applicant after: Liu Xingquan Address before: 250000 Ji'nan, Shandong, Lixia District, Jiefang Road, No. 34 Applicant before: Liu Xingquan |
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| COR | Change of bibliographic data | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20151202 |
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| RJ01 | Rejection of invention patent application after publication |