CN102579764A - Traditional Chinese medicine for preventing and curing recurrent aphthae and preparing method thereof - Google Patents
Traditional Chinese medicine for preventing and curing recurrent aphthae and preparing method thereof Download PDFInfo
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Abstract
The invention provides a traditional Chinese medicine for preventing and curing recurrent aphthae and a preparing method thereof, which comprises ingredients of upright ladybell root, evodia rutaecarpa, cinnamonum cassia, notopterygium root, aloe, indigo naturalis, Chinese gall, cornus officinalis, cistanche deserticola, oldenlandia diffusa, sophora flavescens, polygala tenuifolia, dark plum fruit, coptis chinensis, plantain seed, senna leaf, kudzuvine root, fructus lycii, dried rehmannia root, tree peony bark, licorice and bighead atractylodes rhizome. The traditional Chinese medicine for preventing and curing recurrent aphthae has the advantages of high efficiency and little toxic and side effect, being free of residue, drug resistance and environment pollution, quick effect, low cost and being worthy of popularization on prevention and treatment of recurrent aphthae.
Description
Technical field
The invention belongs to the pharmaceutical engineering technical field, relate in particular to a kind of Chinese medicine that is used to prevent and treat recurrent aphtha.
Background technology
Recurrent aphtha is the recurrent oral ulceration (recurrent ulcer ROU) of doctor trained in Western medicine; Be called recurrent aphtha (RAU) again; For irregularly or periodically isolated or multiple stomatocace occurring, be the clinical modal disease of cari oris mucosa, with being dispersed in property of oral mucosa table fester at any position of oral mucosa; Local scorching hot pain is its clinical characters, has the characteristics of limitation, recurrent, self-healing property.
Though recurrent aphtha is not what serious disease or severe disease, does not have tangible General Symptoms again, but can influence daily live and work in the same old way; Especially speak or very inconvenience during diet, cause drinking and eating irregularly, have a nasty taste; That abandons is hungry, ambiguous in a minute, says and difficulty; Do not say and awkward that spirit is endured puzzlement to the fullest extent.Whenever work strain, pressure increases, and feels depressed, and does not have enough sleep or diet raw food, then brings out primary disease.And modal symptom is lip, cheek, tongue, the mucosal ulcer that locates such as engages rounded or oval, obvious congestion and edema around the ulcer, and the surface has exudate topped, and the affected part has an intense pain.
The recurrent aphtha etiology unknown is true at present, maybe be relevant with factors such as immune status decline, microcirculation disturbance, malnutrition, virus and bacteria infection, heredity.The sickness rate of recurrent aphtha is higher, reports that generally its prevalence is near 20%.Falling ill per capita of all ages and classes section, the women falls ill more than the male, and the ratio of men and women's morbidity is about 2:3.External investigation shows that the general crowd's prevalence of the U.S. reaches as high as 60%, and the child has 1% to suffer from recurrent aphtha approximately, wherein 35%～40% runs initially before 5 years old, and old man's prevalence is merely 1. 7% more than 70 years old.
At present, the western medical treatment recurrent aphtha mainly is to eliminate the inducement of causing a disease, and promotes body Jiankang, alleviates local symptom, promotes ulcer healing.Though certain curative effect is arranged, but still exists side effect big, problem such as the scope of application is narrow.
The Chinese medicine preparation of treatment recurrent aphtha is few; External pulvis has XILEI SAN (heat-clearing and toxic substances removing; The putrefaction removing of drawing out the pus is mainly used in oral ulcer and belongs to damp and hot fumigation, corrupt suppuration person); Be used for attacking on the excess-fire that the toothache BINGPENG SAN of disease, precious black pigment used by women in ancient times to paint their eyebrows loose, oral cavity ulcer powder, match aurification poison loose etc., also have stomatitis spray, ice boron buccal tablet in addition; The kouyanqing granules that is used for syndrome of flaring up of deficient fire.Though but the Chinese patent medicine respite symptom of above-mentioned existing treatment recurrent aphtha also causes the uncomfortable of oral cavity, and can not effect a radical cure recurrent aphtha that its specific aim is not strong, also digestive tract is had intense stimulus, causes diarrhoea easily.
Summary of the invention
Technical problem to be solved by this invention is to be to provide a kind of novel being used to prevent and treat Chinese medicine of recurrent aphtha and preparation method thereof, adopt this Chinese medicine to the prevention and the treatment of recurrent aphtha have efficiently, toxic and side effects is little, noresidue, do not develop immunity to drugs, free from environmental pollution, effect is rapid, cheap, have and advantage such as apply.
Ask in order to solve above-mentioned technology; The invention provides the Chinese medicine of a kind of prevention and treatment recurrent aphtha, it comprises: Radix Adenophorae, Fructus Evodiae, Cortex Cinnamomi, Rhizoma Et Radix Notopterygii, Aloe, Indigo Naturalis, Galla Chinensis, Fructus Corni, Herba Cistanches, Herba Hedyotidis Diffusae, Radix Sophorae Flavescentis, Radix Polygalae, Fructus Mume, Rhizoma Coptidis, Semen Plantaginis, Folium Sennae, Radix Puerariae, Fructus Lycii, Radix Rehmanniae, Cortex Moutan, Radix Glycyrrhizae and the Rhizoma Atractylodis Macrocephalae.
Wherein, the ratio of weight and number of various components can be Radix Adenophorae 20～25 weight portions, Fructus Evodiae 12～16 weight portions, Cortex Cinnamomi 6～10 weight portions, Rhizoma Et Radix Notopterygii 10～15 weight portions, Aloe 25～35 weight portions, Indigo Naturalis 30～40 weight portions, Galla Chinensis 10～15 weight portions, Fructus Corni 17～23 weight portions, Herba Cistanches 12～18 weight portions, Herba Hedyotidis Diffusae 20～25 weight portions, Radix Sophorae Flavescentis 20～25 weight portions, Radix Polygalae 8～12 weight portions, Fructus Mume 18～22 weight portions, Rhizoma Coptidis 60～70 weight portions, Semen Plantaginis 15～20 weight portions, Folium Sennae 13～17 weight portions, Radix Puerariae 10～15 weight portions, Fructus Lycii 20～25 weight portions, Radix Rehmanniae 25～35 weight portions, Cortex Moutan 25～35 weight portions, Radix Glycyrrhizae 25～30 weight portions and the Rhizoma Atractylodis Macrocephalae 20～25 weight portions.
Wherein, the ratio of weight and number of various components can be Radix Adenophorae 22～25 weight portions, Fructus Evodiae 14～16 weight portions, Cortex Cinnamomi 8～10 weight portions, Rhizoma Et Radix Notopterygii 12～15 weight portions, Aloe 30～35 weight portions, Indigo Naturalis 35～40 weight portions, Galla Chinensis 12～15 weight portions, Fructus Corni 20～23 weight portions, Herba Cistanches 15～18 weight portions, Herba Hedyotidis Diffusae 22～25 weight portions, Radix Sophorae Flavescentis 22～25 weight portions, Radix Polygalae 10～12 weight portions, Fructus Mume 20～22 weight portions, Rhizoma Coptidis 65～70 weight portions, Semen Plantaginis 18～20 weight portions, Folium Sennae 15～17 weight portions, Radix Puerariae 12～15 weight portions, Fructus Lycii 22～25 weight portions, Radix Rehmanniae 30～35 weight portions, Cortex Moutan 30～35 weight portions, Radix Glycyrrhizae 27～30 weight portions and the Rhizoma Atractylodis Macrocephalae 22～25 weight portions.
Wherein, also contain Radix Trichosanthis in the said Chinese medicine, the ratio of weight and number of said Radix Trichosanthis in said Chinese medicine is Radix Trichosanthis 6～10 weight portions.
Wherein, the dosage form of said Chinese medicine is capsule, spray or paster.
The present invention also provides above-mentioned preparation method of Chinese medicine, and when the dosage form of said Chinese medicine was capsule, it comprised,
The first step; With said component proportional mixing, to add determining alcohol be that 80%～90% alcohol heating reflux extracts 2～4 times, and the extracting solution that obtains is merged, filter; Concentrating under reduced pressure; Remove the ethanol of mass percent 80%～90%, obtain concentrated solution, the alcoholic acid quality that is added is 2～4 times of mixture quality;
In second step, above-mentioned concentrated solution is through macroporous adsorptive resins, and elder generation is with the deionized water or the distilled water eluting of 3～5 times of resin column volumes; The determining alcohol of 2～4 times of resin column volumes of reuse is 90%～95% ethanol elution, collects ethanol elution, and concentrating under reduced pressure becomes thick paste; Dry; Be ground into fine powder, sieve, obtain 50 orders～100 purpose fine powders;
The 3rd step with the fine powder that obtains and starch, magnesium stearate stirring and evenly mixing, incapsulated the acquisition capsule, and with respect to the fine powder of 100 weight portions, the addition of said starch is 20～30 weight portions, and the addition of magnesium stearate is 0.5～2 weight portion.
The present invention also provides above-mentioned preparation method of Chinese medicine, and when the dosage form of said Chinese medicine was spray, it comprised,
The first step; With said component proportional mixing, to add determining alcohol be that 80%～90% alcohol heating reflux extracts 2～4 times, and the extracting solution that obtains is merged, filter; Concentrating under reduced pressure; Remove the ethanol of mass percent 80%～90%, obtain concentrated solution, the alcoholic acid quality that is added is 2～4 times of mixture quality;
In second step, above-mentioned concentrated solution is through macroporous adsorptive resins, and elder generation is with the deionized water or the distilled water eluting of 3～5 times of resin column volumes; The determining alcohol of 2～4 times of resin column volumes of reuse is 90%～95% ethanol elution, collects ethanol elution, and concentrating under reduced pressure becomes thick paste; Dry; Be ground into fine powder, sieve, obtain 50 orders～100 purpose fine powders;
The 3rd step went on foot the fine powder that obtains with respect to second of 100 weight portions, with 50～200 weight portion distilled water dilutings, poured into spray bottle, made spray.
The present invention also provides above-mentioned preparation method of Chinese medicine, and when the dosage form of said Chinese medicine was paster, it comprised:
The first step; With said component proportional mixing, to add determining alcohol be that 80%～90% alcohol heating reflux extracts 2～4 times, and the extracting solution that obtains is merged, filter; Concentrating under reduced pressure; Remove the ethanol of mass percent 80%～90%, obtain concentrated solution, the alcoholic acid quality that is added is 2～4 times of mixture quality;
In second step, above-mentioned concentrated solution is through macroporous adsorptive resins, and elder generation is with the deionized water or the distilled water eluting of 3～5 times of resin column volumes; The determining alcohol of 2～4 times of resin column volumes of reuse is 90%～95% ethanol elution, collects ethanol elution, and concentrating under reduced pressure becomes thick paste; Dry; Be ground into fine powder, sieve, obtain 50 orders～100 purpose fine powders;
The 3rd step was ground into smalls with pulverizer respectively with hydroxypropyl emthylcellulose binding agent and excipient magnesium stearate, sieved respectively, obtained 50 orders～100 purpose fine powders;
The 4th step went on foot the material and the 3rd that obtains that sieves with second and goes on foot the material mix homogeneously that sieves and obtain, and was pressed into paster.
Beneficial effect of the present invention:
This Chinese medicine provided by the invention to the prevention and the treatment of recurrent aphtha have efficiently, toxic and side effects is little, noresidue, do not develop immunity to drugs, free from environmental pollution, effect is rapid, cheap, have and advantage such as apply.
The specific embodiment
The morbidity of recurrent aphtha main with autoimmune lowly, endocrine dysfunction, inherited genetic factors and Nervous and Mental Factors be relevant, motherland's medical science claims that primary disease is " aphtha ", " erosion of the oral mucosa ", " aphtha " etc." interior warp " claimed " the routed skin ulcer of all pains all belongs to the heart "." medical secrets of official " said " heart spleen has the normal aphtha of suffering from of heat "." Shengji Zonglu " carries " aphtha person's heart spleen has heat, and gas rushes to Jiao, smoked send out a dispute pretend skin ulcer also ", and " stomach-QI being weak, essence derived from food is little, empty cloudy going up sent out and be aphtha ", visible primary disease and wind-fire pathogenic dryness and internal damage by the excessive seven emotions, factor such as surfeit is pungent is relevant.Card belongs to hyperactivity of fire caused by deficiency of YIN, stagnation of dampness due to deficiency of the spleen, and the taste excess-heat, the lung gastric heat is stopped up, deficiency of both QI and blood etc.Treatment is with nourishing YIN and clearing away fire, invigorating spleen to remove dampness, and clearing away heat and cooling blood, the respectful lung of clearing stomach, qi and blood tonifying are principle.And do not have sink heart sthenia gastropyrexia or a Liver and kidney asthenic fire, all can in return taste, cause gastrointestinal development of evil in febrile disease mistake department, pure and impure mixing, retention of damp-heat in the interior is upward smoked dispute and is formed ulcer.Therefore, the treatment of recurrent aphtha need be a principle with clearing heat and expelling damp, eliminating fire and detoxication.
Based on mentioned above principle; The invention provides the Chinese medicine of a kind of prevention and treatment recurrent aphtha, it comprises: Radix Adenophorae, Fructus Evodiae, Cortex Cinnamomi, Rhizoma Et Radix Notopterygii, Aloe, Indigo Naturalis, Galla Chinensis, Fructus Corni, Herba Cistanches, Herba Hedyotidis Diffusae, Radix Sophorae Flavescentis, Radix Polygalae, Fructus Mume, Rhizoma Coptidis, Semen Plantaginis, Folium Sennae, Radix Puerariae, Fructus Lycii, Radix Rehmanniae, Cortex Moutan, Radix Glycyrrhizae and the Rhizoma Atractylodis Macrocephalae.
Wherein, each component pharmacology is following:
Radix Adenophorae: sweet in the mouth, little hardship, cold nature is gone into lung, stomach warp; Nourishing the lung to arrest cough is arranged, the effect of nourishing the stomach to promote the production of body fluid, the dry cough that is mainly used in thermal burn lung yin or lung-dryness syndrome due to deficiency of YIN is lacked expectorant; The consumptive lung disease cough, the apoplexy due to phlegm blood streak, and calentura injures the withered symptoms such as thirsty and dry pharynx of stomach-Yin or prolonged illness deficiency of YIN Tianjin.
Fructus Evodiae: hot in nature, acrid in the mouth, hardship have dispersing cold for relieving pain, stopping nausea and vomiting by lowering the adverse flow of QI, and supporing yang antidiarrheal effect is used for headache due to JUE YIN disorder, colic of cold type stomachache, the disturbance of lower legs due to pathogenic cold and dampness, abdominal pain during menstruation, abdominal distention, the vomiting acid regurgitation is had loose bowels external treatment aphtha, cards such as hypertension just before dawn.
Cortex Cinnamomi: extremely hot in nature, acrid in the mouth, sweet is returned kidney, spleen, the heart, Liver Channel, and it is fiery supporing yang to have benefit, let the fire back to its origin, dispersing cold for relieving pain; The effect of promoting blood circulation to restore menstrual flow is used for warming the spleen and stomach, removing accumulated cold, and promoting blood circulation is controlled decline of the fire from the gate of life; The cold extremities faint pulse, the YANG-depletion collapse, stomachache is had loose bowels, colic of cold type renal mass, chills and pain of the waist and kness; The amenorrhea lump in the abdomen, carbuncle of yin nature, multiple abscess, and empty sun is more floating, cards such as heat in the upper and cold in the lower.
Rhizoma Et Radix Notopterygii: acrid in the mouth, hardship, warm in nature, go into kidney, urinary bladder channel, have the cold expelling of inducing sweat, expelling wind and dampness, analgesic effect, have the wet exterior syndrome of wind and cold folder, disease is seen fever with aversion to cold, headache as is wrapped up in, neck rigid back pain, limbs are heavy, and joint is ached, cards such as anemofrigid-damp arthralgia.
Aloe: bitter in the mouth, cold in nature, return liver, large intestine channel, have the cool liver of heat clearing away, relieving constipation by purgation, the parasiticidal effect of the infantile malnutrition that disappears cures mainly the liver-fire headache, conjunctival congestion and swelling pain, dysphoria with smothery sensation infantile convulsion, constipation with heat retention, abdominal pain due to worm stagnation, infantile malnutrition, eczema scabies, cards such as hemorrhoid complicated by anal fistula.
Indigo Naturalis: salty in the mouth; Cold in nature; Go into Liver Channel, have the effect of heat-clearing and toxic substances removing, cooling blood for hemostasis, purging liver-fire, be used for epidemic febrile disease and send out cards such as all cards of pyretic toxicity such as speckle, haematemesis, laryngopharynx swelling and pain, herpes eczema, liver-fire invading the lung, cough chest pain, sputum mixed with blood, hyperpyrexia infantile convulsion, convulsion with spasms.
Galla Chinensis: sour in the mouth, puckery, cold in nature, return lung, large intestine, kidney channel, have the effect of astringent or styptic treatment for spontaneous sweating, the supplementing QI for promoting the production of body fluid of convergence, kidney calming, cure mainly: chronic cough of deficiency lung; Spontaneous sweating; The chronic dysentery chronic diarrhea; Proctoptosis; Seminal emission; Nebulousurine; Various hemorrhage; Cards such as carbuncle furuncle, Galla Chinensis ability enhancing body can strengthen the immunologic function of cell to the defence capability of nonspecific stimulation, this pathogenic bacterium are had inhibitory action, and can grow by antiviral, have good anti-inflammation hemostasia function.
Fructus Corni: sour in the mouth, puckery, slightly warm in nature is returned liver, kidney channel, has liver and kidney tonifying, the effect of essence astringing and desertion stemming.Be used for vertigo and tinnitus, soreness of waist and knee joint, impotence and seminal emission, enuresis frequent micturition, bleeding not during menses, profuse sweating collapse.Interior-heat card such as quench one's thirst.
Herba Cistanches: sweet in the mouth, salty, warm in nature, go into kidney, large intestine channel; Kidney-replenishing, benefiting essence-blood are arranged, and the effect of loosening bowel to relieve constipation is used for kidney yang deficiency, the impotence and premature ejaculation of asthenia of essence and blood; Sterility and infertility, soreness of waist and knee joint, Hiccough and deaf, frequent micturition urine number; Suffer from a deficiency of the kidney dryness of the intestine and puerperal blood deficiency, the cards such as constipation of deficiency of body fluid after being ill, can strengthen body fluid and cellular immune function, strengthen the mononuclear phagocyte phagocytic activity.
Herba Hedyotidis Diffusae: bitter in the mouth, sweet, cold in nature, go into the heart, liver, spleen, large intestine channel has heat-clearing and toxic substances removing; The effect of promoting diuresis to eliminate damp pathogen is used for dyspnea and cough due to lung-heat, laryngopharynx swelling and pain, acute appendicitis, furuncle and phyma skin infection, venom; The puckery pain of pyretic stranguria, edema, dysentery, enteritis, jaundice due to damp-heat, cards such as cancerous protuberance.
Radix Sophorae Flavescentis: bitter in the mouth, cold in nature, go into liver, kidney, large intestine, small intestinal, bladder, heart channel, have heat clearing and damp drying, the effect of wind dispelling insecticide cures mainly damp-heat dysentery; Discharging fresh blood stool, jaundice, dysuria, edema, leukorrhagia; Pudendal pruritus, scabies, leprosy, skin pruritus, cards such as noxious dampness skin infection.
Radix Polygalae: bitter in the mouth, suffering, slightly warm in nature, GUIXIN, kidney, lung meridian have the Fructus Alpiniae Oxyphyllae of calming the nerves, and eliminate the phlegm, and the repercussive effect is used for the insomnia and dreamful sleep that disarmony between the heart and kidney causes, forgetful palpitation with fear, staring spells, expectoration is not well, sore swollen toxin, cards such as breast swell and pain.
Fructus Mume: bitter in the mouth, acid, puckery, warm in nature, go into liver, lung, spleen, large intestine channel, have and astringe the lung; Astringing intestine to stop diarrhea, hemostasis, the effect of promoting the production of body fluid, it is more than to be used to treat chronic dysentery; Damp-heat dysentery is had blood in stool, card such as hematuria, snowslide, and is inhibited to multiple pathogenic bacterias such as dysentery bacterium, escherichia coli, Bacillus typhi.
Rhizoma Coptidis: bitter in the mouth, cold in nature, go into the heart, lung, gallbladder, stomach, large intestine channel, heat clearing and damp drying is arranged, eliminating fire and detoxication; The effect of cooling blood for improving eyesight cures mainly damp and hot feeling of fullness, vomiting acid regurgitation, dysentery, jaundice; Unconsciousness due to high fever, hyperactivity of heart-fire, dysphoria and insomnia, heat in blood is told nosebleed, conjunctival congestion; Carbuncle furuncle, eczema, eczema are quenched one's thirst in toothache; Auditory meatus card such as suppurate, Rhizoma Coptidis mainly contains alkaloids such as berberine, is light broad spectrum antiviral drug thing, can effectively reduce the drug resistance of Salmonella, and staphylococcus aureus, blood dissolubility streptococcus, streptococcus pneumoniae, meningococcus, dysentery bacterium etc. are had stronger bacteriostasis.
Semen Plantaginis: sweet in the mouth, cold in nature, go into liver, kidney, small intestinal, lung, urinary bladder channel, clearing away heat and promoting diuresis is arranged, expelling phlegm for arresting cough, the effect that makes eye bright, the cough that is mainly used in wind-heat invading the lung is spat; The conjunctival congestion and swelling pain of liver-fire rising; Damp and hot accumulateing in the dysuria of the part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels, accumulation of heat in the urinary bladder, cards such as jaundice due to damp-heat.
Folium Sennae: sweet in the mouth, hardship, cold in nature, go into large intestine channel, purging heat to relax the bowels is arranged, the stagnate merit of diuretic of row is mainly used in the constipation of the stagnant the intestines and stomach of accumulation of heat, the abdominal distention abdominal distention of accumulation of food in the stomach and intes tine due to indigestion, symptoms such as anorexia.
Radix Puerariae: sweet in the mouth, suffering, cool in nature, go into spleen, stomach warp, the inspiration gastric qi is arranged, clearing away heat and promoting production of body fluid, expelling pathogenic factors from muscles is delivered, and gives birth to sun, oozes the effect of rash, is mainly used in fever caused by exogenous pathogens, headache, stiff nape and back, calentura is thirsty, quenches one's thirst; Diarrhea due to hypofunction of the spleen, cards such as clear YANG failing to ascend, intrinsic heat during the light clear expelling heat from the exterior of Radix Puerariae is wet.
Radix Rehmanniae: sweet in the mouth, hardship, cool in nature, go into the heart, liver, kidney channel, have the effect of clearing away heat and promoting production of body fluid nourishing YIN and benefiting blood, cure mainly fever due to yin deficiency, quench one's thirst, spit blood, epistaxis, metrorrhagia, menoxenia, frequent fetal movement, the moon is hindered cards such as constipation.
Cortex Moutan: cold in nature, bitter in the mouth, GUIXIN, liver, kidney, lung meridian have the effect of clearing away heat and cooling blood, promoting blood circulation to remove blood stasis, are used for the epidemic febrile disease pathogenic heat attacking blood system in febrile diseases; Send out speckle, tell nosebleed, the calentura later stage, hot Fu Yin divided heating, deficiency of YIN osteopyrexia and fever, amenorrhea due to stagnation of blood; Dysmenorrhea, carbuncle sore tumefacting virus falls and pounces on the pain of injury, cards such as rheumatism pyretic arthralgia.
Radix Glycyrrhizae: sweet in the mouth, property is flat, goes into 12 warps, and heat-clearing and toxic substances removing is arranged, and is in harmonious proportion the property of medicine, the effect of expelling phlegm for arresting cough, and can spleen invigorating with in, relieving spasm to stop pain is mainly used in the abdominal distension and anorexia of weakness of the spleen and stomach, and is weak; Can alleviate contracture property pain in the abdomen, relax the strong and toxicity of some drugs, alleviating medicine stimulates to the toxic and side effects of body or to gastrointestinal, can play the QI invigorating neutralization through adding Radix Glycyrrhizae, is in harmonious proportion the effect of each component.
The Rhizoma Atractylodis Macrocephalae: sweet in the mouth, hardship, warm in nature, go into spleen, stomach warp, the spleen reinforcing promoting the circulation of QI is arranged, the dampness diuretic, strengthening superficial resistance to stop perspiration, the effect that activating the spleen is moisturized is mainly used in the feeling of fullness diarrhoea due to dysfunction of the spleen in transportation, the QI failing to transform into body fluid, the phlegm retention edema; The vexed lazy speech of deficiency of QI in middle-JIAO, metrorrhagia and metrostaxis, proctoptosis with chronic dysentery; Cards such as solid in the playing of deficiency of the spleen causing weakness of QI, sweating due to debility spontaneous perspiration, the Rhizoma Atractylodis Macrocephalae can promote gastric secretion, strengthens the Absorption of small intestinal, and gastrointestinal function is had regulating action.
Further preferred, said Chinese medicine ingredients only is made up of said components.
In the said Chinese medicine, the ratio of weight and number of various components can be preferably: Radix Adenophorae 20～25 weight portions, Fructus Evodiae 12～16 weight portions, Cortex Cinnamomi 6～10 weight portions, Rhizoma Et Radix Notopterygii 10～15 weight portions, Aloe 25～35 weight portions, Indigo Naturalis 30～40 weight portions, Galla Chinensis 10～15 weight portions, Fructus Corni 17～23 weight portions, Herba Cistanches 12～18 weight portions, Herba Hedyotidis Diffusae 20～25 weight portions, Radix Sophorae Flavescentis 20～25 weight portions, Radix Polygalae 8～12 weight portions, Fructus Mume 18～22 weight portions, Rhizoma Coptidis 60～70 weight portions, Semen Plantaginis 15～20 weight portions, Folium Sennae 13～17 weight portions, Radix Puerariae 10～15 weight portions, Fructus Lycii 20～25 weight portions, Radix Rehmanniae 25～35 weight portions, Cortex Moutan 25～35 weight portions, Radix Glycyrrhizae 25～30 weight portions and the Rhizoma Atractylodis Macrocephalae 20～25 weight portions.
In the said Chinese medicine, the ratio of weight and number of various components also can further be preferably: Radix Adenophorae 22～25 weight portions, Fructus Evodiae 14～16 weight portions, Cortex Cinnamomi 8～10 weight portions, Rhizoma Et Radix Notopterygii 12～15 weight portions, Aloe 30～35 weight portions, Indigo Naturalis 35～40 weight portions, Galla Chinensis 12～15 weight portions, Fructus Corni 20～23 weight portions, Herba Cistanches 15～18 weight portions, Herba Hedyotidis Diffusae 22～25 weight portions, Radix Sophorae Flavescentis 22～25 weight portions, Radix Polygalae 10～12 weight portions, Fructus Mume 20～22 weight portions, Rhizoma Coptidis 65～70 weight portions, Semen Plantaginis 18～20 weight portions, Folium Sennae 15～17 weight portions, Radix Puerariae 12～15 weight portions, Fructus Lycii 22～25 weight portions, Radix Rehmanniae 30～35 weight portions, Cortex Moutan 30～35 weight portions, Radix Glycyrrhizae 27～30 weight portions and the Rhizoma Atractylodis Macrocephalae 22～25 weight portions.
For the patient that the pain increased, the said Chinese medicine that is used for preventing and treats recurrent aphtha can also comprise Radix Trichosanthis, and the ratio of weight and number of said Radix Trichosanthis in said Chinese medicine is Radix Trichosanthis 6～10 weight portions.
Radix Trichosanthis: i.e. Radix Trichosanthis, sweet in the mouth, little hardship, lung, stomach warp are gone in property acid, cold, and clearing away heat and promoting production of body fluid is arranged, moistening the lung and resolving the phlegm, the effect of detumescence and apocenosis is mainly used in the excessive thirst of consumption of body fluid caused by febrile disease, diabetes, cough caused by dryness-heat, symptoms such as carbuncle sore tumefacting virus.
The present invention is used to prevent and the dosage form of treating the Chinese medicine of recurrent aphtha can be capsule, spray, paster.
The present invention also provides a kind of preparation method of Chinese medicine that is used to prevent and treat recurrent aphtha, and when the dosage form of said Chinese medicine was capsule, it comprised:
The first step; With said component proportional mixing, to add determining alcohol be that 80%～90% alcohol heating reflux extracts 2～4 times, and the extracting solution that obtains is merged, filter; Concentrating under reduced pressure; Remove the ethanol of mass percent 80%～90%, obtain concentrated solution, the alcoholic acid quality that is added is 2～4 times of mixture quality;
In second step, above-mentioned concentrated solution is through macroporous adsorptive resins, and elder generation is with the deionized water or the distilled water eluting of 3～5 times of resin column volumes; The determining alcohol of 2～4 times of resin column volumes of reuse is 90%～95% ethanol elution, collects ethanol elution, and concentrating under reduced pressure becomes thick paste; Dry; Be ground into fine powder, sieve, obtain 50 orders～100 purpose fine powders;
The 3rd step with the fine powder that obtains and starch, magnesium stearate stirring and evenly mixing, incapsulated the acquisition capsule, and with respect to the fine powder of 100 weight portions, the addition of said starch is 20～30 weight portions, and the addition of magnesium stearate is 0.5～2 weight portion.
The present invention also provides a kind of preparation method of Chinese medicine that is used to prevent and treat recurrent aphtha, and when the dosage form of said Chinese medicine was spray, it comprised:
The first step; With said component proportional mixing, to add determining alcohol be that 80%～90% alcohol heating reflux extracts 2～4 times, and the extracting solution that obtains is merged, filter; Concentrating under reduced pressure; Remove the ethanol of mass percent 80%～90%, obtain concentrated solution, the alcoholic acid quality that is added is 2～4 times of mixture quality;
In second step, above-mentioned concentrated solution is through macroporous adsorptive resins, and elder generation is with the deionized water or the distilled water eluting of 3～5 times of resin column volumes; The determining alcohol of 2～4 times of resin column volumes of reuse is 90%～95% ethanol elution, collects ethanol elution, and concentrating under reduced pressure becomes thick paste; Dry; Be ground into fine powder, sieve, obtain 50 orders～100 purpose fine powders;
The 3rd step went on foot the fine powder that obtains with respect to second of 100 weight portions, with 50～200 weight portion distilled water dilutings, poured into spray bottle, made spray.
The present invention also provides a kind of preparation method of Chinese medicine that is used to prevent and treat recurrent aphtha, and when the dosage form of said Chinese medicine was paster, it comprised:
The first step; With said component proportional mixing, to add determining alcohol be that 80%～90% alcohol heating reflux extracts 2～4 times, and the extracting solution that obtains is merged, filter; Concentrating under reduced pressure; Remove the ethanol of mass percent 80%～90%, obtain concentrated solution, the alcoholic acid quality that is added is 2～4 times of mixture quality;
In second step, above-mentioned concentrated solution is through macroporous adsorptive resins, and elder generation is with the deionized water or the distilled water eluting of 3～5 times of resin column volumes; The determining alcohol of 2～4 times of resin column volumes of reuse is 90%～95% ethanol elution, collects ethanol elution, and concentrating under reduced pressure becomes thick paste; Dry; Be ground into fine powder, sieve, obtain 50 orders～100 purpose fine powders;
The 3rd step was ground into smalls with pulverizer respectively with hydroxypropyl emthylcellulose binding agent and excipient magnesium stearate, sieved respectively, obtained 50 orders～100 purpose fine powders;
The 4th step went on foot the material and the 3rd that obtains that sieves with second and goes on foot the material mix homogeneously that sieves and obtain, and was pressed into paster.
With respect to the gross weight meter of said paster, comprise the binding agent of 10～80 weight % and the excipient of 5.0～60 weight % in the said mouth paster.
Said macroporous adsorbent resin can be commercially available any macroporous adsorbent resin, further is preferably AB-8 type, D101 type, Amberlite 252 types or Diaion HP-20 type macroporous adsorbent resin.
Below adopt embodiment to specify embodiment of the present invention, how the application technology means solve technical problem to the present invention whereby, and the implementation procedure of reaching technique effect can make much of and implement according to this.
The toxicity test of embodiment 1 Chinese medicine of the present invention
The experiment medicine
It is 90% ethanol 1600g heating and refluxing extraction 3 times that Radix Adenophorae 23g, Fructus Evodiae 15g, Cortex Cinnamomi 9g, Rhizoma Et Radix Notopterygii 14g, Aloe 32g, Indigo Naturalis 38g, Galla Chinensis 15g, Fructus Corni 22g, Herba Cistanches 18g, Herba Hedyotidis Diffusae 25g, Radix Sophorae Flavescentis 25g, Radix Polygalae 12g, Fructus Mume 22g, Rhizoma Coptidis 68g, Semen Plantaginis 20g, Folium Sennae 16g, Radix Puerariae 15g, Fructus Lycii 25g, Radix Rehmanniae 35g, Cortex Moutan 32g, Radix Glycyrrhizae 28g and Rhizoma Atractylodis Macrocephalae 25g are mixed, add determining alcohol, and the extracting solution that obtains is merged, and filters; Concentrating under reduced pressure is removed the ethanol of mass percent 80%, obtains concentrated solution; With concentrated solution through 6LAB-8 type macroporous adsorptive resins; With the deionized water eluting of 4 times of resin column volumes, the determining alcohol of 4 times of resin column volumes of reuse is 95% ethanol elution earlier, collects ethanol elution; Concentrating under reduced pressure becomes thick paste; Drying is ground into fine powder, sieves; Obtain 50 purpose fine powders; With the fine powder that obtains and 160g starch, 6g magnesium stearate stirring and evenly mixing, incapsulate the acquisition capsule, capsule is dissolved in to obtain in the deionized water to irritate obeys solution.
Experimental technique
Get 40 of mices, male and female half and half, body weight 20～25g; Fasting (can't help water) 12h before the experiment; The maximum volume (0.6ml/10g) that can irritate clothes by mice is irritated solution (the 2.667g crude drug in whole/ml), and within 1 day, connect and irritate each 8h at interval 3 times that can irritate clothes concentration with maximum.Give animal with normal diet then, observed continuously 7 days, it is dead not see that mice occurs.Rarely seen animal has minimizing just for the medicine activity slightly, and the activity of the 2nd time and the 3rd time administration reduces, and mice is movable behind general administration 2～3h recovers normal; The jaundice slightly of the 1st day visible mice urine, stool rubicundity, rare slightly, diet reduces with drinking-water; Visible mice stool color was rubescent slightly, rare slightly in the 2nd day, but was shaped, and diet reduces with drinking-water slightly; The 3rd day mice is complete to recover normal, do not see diet is arranged, hair color, two just, autonomic activities etc. obviously unusual.Weigh behind the 7th day mice fasting (the can't help water) 12h, put to death, dissect mice again, the obviously unusual of macroscopic liver, the heart, spleen, lung, kidney, stomach, intestinal, brain etc. do not arranged.
The preparation of embodiment 2 capsules
It is 90% ethanol 1600g heating and refluxing extraction 3 times that Radix Adenophorae 23g, Fructus Evodiae 15g, Cortex Cinnamomi 9g, Rhizoma Et Radix Notopterygii 14g, Aloe 32g, Indigo Naturalis 38g, Galla Chinensis 15g, Fructus Corni 22g, Herba Cistanches 18g, Herba Hedyotidis Diffusae 25g, Radix Sophorae Flavescentis 25g, Radix Polygalae 12g, Fructus Mume 22g, Rhizoma Coptidis 68g, Semen Plantaginis 20g, Folium Sennae 16g, Radix Puerariae 15g, Fructus Lycii 25g, Radix Rehmanniae 35g, Cortex Moutan 32g, Radix Glycyrrhizae 28g and Rhizoma Atractylodis Macrocephalae 25g are mixed, add determining alcohol, and the extracting solution that obtains is merged, and filters; Concentrating under reduced pressure is removed the ethanol of mass percent 80%, obtains concentrated solution; Through 6LAB-8 type macroporous adsorptive resins, with the deionized water eluting of 4 times of resin column volumes, the determining alcohol of 4 times of resin column volumes of reuse is 95% ethanol elution earlier with concentrated solution; Collect ethanol elution; Concentrating under reduced pressure becomes thick paste, and drying is ground into fine powder; Sieve; Obtain 50 purpose fine powders,, incapsulate the acquisition capsule the fine powder that obtains and 160g starch, 6g magnesium stearate stirring and evenly mixing.
The preparation of embodiment 3 sprays
It is 90% ethanol 1600g heating and refluxing extraction 3 times that Radix Adenophorae 23g, Fructus Evodiae 15g, Cortex Cinnamomi 9g, Rhizoma Et Radix Notopterygii 14g, Aloe 32g, Indigo Naturalis 38g, Galla Chinensis 15g, Fructus Corni 22g, Herba Cistanches 18g, Herba Hedyotidis Diffusae 25g, Radix Sophorae Flavescentis 25g, Radix Polygalae 12g, Fructus Mume 22g, Rhizoma Coptidis 68g, Semen Plantaginis 20g, Folium Sennae 16g, Radix Puerariae 15g, Fructus Lycii 25g, Radix Rehmanniae 35g, Cortex Moutan 32g, Radix Glycyrrhizae 28g and Rhizoma Atractylodis Macrocephalae 25g are mixed, add determining alcohol, and the extracting solution that obtains is merged, and filters; Concentrating under reduced pressure is removed the ethanol of mass percent 80%, obtains concentrated solution; Through 6LAB-8 type macroporous adsorptive resins, with the deionized water eluting of 4 times of resin column volumes, the determining alcohol of 4 times of resin column volumes of reuse is 95% ethanol elution earlier with concentrated solution; Collect ethanol elution, concentrating under reduced pressure becomes thick paste, drying; Be ground into fine powder; Sieve, obtain 50 purpose fine powders, fine powder is used the 50kg distilled water diluting; Pour into spray bottle, make spray.
The preparation of embodiment 4 pasters
It is 90% ethanol 1600g heating and refluxing extraction 3 times that Radix Adenophorae 23g, Fructus Evodiae 15g, Cortex Cinnamomi 9g, Rhizoma Et Radix Notopterygii 14g, Aloe 32g, Indigo Naturalis 38g, Galla Chinensis 15g, Fructus Corni 22g, Herba Cistanches 18g, Herba Hedyotidis Diffusae 25g, Radix Sophorae Flavescentis 25g, Radix Polygalae 12g, Fructus Mume 22g, Rhizoma Coptidis 68g, Semen Plantaginis 20g, Folium Sennae 16g, Radix Puerariae 15g, Fructus Lycii 25g, Radix Rehmanniae 35g, Cortex Moutan 32g, Radix Glycyrrhizae 28g and Rhizoma Atractylodis Macrocephalae 25g are mixed, add determining alcohol, and the extracting solution that obtains is merged, and filters; Concentrating under reduced pressure is removed the ethanol of mass percent 80%, obtains concentrated solution; Through 6LAB-8 type macroporous adsorptive resins, with the deionized water eluting of 4 times of resin column volumes, the determining alcohol of 4 times of resin column volumes of reuse is 95% ethanol elution earlier with concentrated solution; Collect ethanol elution, concentrating under reduced pressure becomes thick paste, drying; Be ground into fine powder; Sieve, obtain 50 purpose fine powders, 500g hydroxypropyl emthylcellulose and 50g magnesium stearate are ground into smalls with pulverizer respectively; Sieve respectively; Obtain 50 purpose fine powders, the fine powder material mix homogeneously with sieving and obtain in the front is pressed into paster.
Embodiment 5 clinical experiment diagnostic criterias
The diagnostic criteria of recurrent aphtha in the diagnosis basis " oral medicine ".This morbidity of patient is preceding without any treatment to going to a doctor, and does not use any corticosteroid and immunosuppressant in nearly March.Exclusion standard: (1) does not meet the non-recurrent aphtha of diagnostic criteria, like traumatic ulcer, cancer ulcer, infective ulcer, and other ulcer persons; (2) patient is taken too drastic plain type medicine in the recent period orally or was accepted immunization therapy; (3) can not cooperate completion clinical observation person; (4) there are other possibly cause oral ulcer or influence the disease of oral ulcer treatment.
Physical data
According to above-mentioned diagnostic criteria, accept recurrent aphtha patient 156 examples year June altogether for medical treatment from January, 2010～2011, male's 90 examples wherein, women's 66 examples: 18～60 years old age, average 28. 5 years old: the course of disease 1～20 year, average 5 years.Oral ulcer was shown effect 1 time or was not had the intermission in every month, went to a doctor and did not use any immune formulation, all patients not to have other oral mucosa disease and whole body systemic disease in preceding 1 month.
Clinical manifestation
(1) light-duty: good sending out in relatively poor oral mucosa districts of keratinization such as lip, tongue, cheek, palates.From the beginning of being small red dot, accompany scorching hot sense of discomfort, expand as the fester of diameter 2～3 mm gradually, nick, on cover faint yellow pseudomembrane, hyperemia is blush shape, causalgia around the ulcer.7～10 d healing can be recurred again after certain intermission.(2) stomatitis type: form is like light-duty, and the ulcer number nearly more than 10, is dispersed in distribution, and General Symptomies such as lymphadenectasis, heating are arranged.(3) heavy type: also claim mikulicz's ulcer, ulcer often is single, can expand as big and dark " crater " shape.Congested on every side, substrate is little, and diameter reaches 1～2cm firmly to nodositas, and General Symptoms is obvious, and healing in 3～4 months can be stayed cicatrix or damaged.(4) this organizes light-duty 68 examples of 156 routine patients, stomatitis type 57 examples, heavy 31 examples.
Therapeutic Method
Matched group 56 examples: give the bisfentidine ranitidine 150 mg, every day 2 times is oral.100 examples are organized in treatment: adopt the Chinese medicinal capsule agent treatment in the embodiment of the invention 2, every capsules 0.3g, every day 3 times.Two groups was 1 course of treatment with 1 month all, treated 2～3 courses of treatment continuously.
The therapeutic evaluation standard
Cure: the ulcer outbreak intermission prolongs, and prolongs more than 1 month than the former intermission.Take a turn for the better: the ulcer healing time accelerates, and the ulcer healing phase shortens more than 1/3 or 1/3: more than the ulcer reduced 1/3 or 1/3; Pain degree alleviates, the ulcer decreased number.Invalid: symptom and sign do not have obvious improvement.
Statistical method
Use X
2The check, with P≤0. 05 for significant difference is arranged.
The result
Can know that through table 1 two groups of curative effect difference has significance (P < 0.05), treatment group curative effect obviously is better than matched group.
Table 1 treatment group and matched group curative effect be (example) relatively
| Group | Cure | Take a turn for the better | Invalid | Total effective rate (%) |
| The treatment group | 65 | 31 | 4 | 96 |
| Matched group | 23 | 12 | 21 | 62.5 |
This intellectual property of primary enforcement that all are above-mentioned is not set restriction this new product of other forms of enforcement and/or new method.Those skilled in the art will utilize this important information, and foregoing is revised, to realize similar implementation status.But all modifications or transformation belong to the right of reservation based on new product of the present invention.
The above only is preferred embodiment of the present invention, is not to be the restriction of the present invention being made other form, and any professional and technical personnel of being familiar with possibly utilize the technology contents of above-mentioned announcement to change or be modified as the equivalent embodiment of equivalent variations.But everyly do not break away from technical scheme content of the present invention, to any simple modification, equivalent variations and remodeling that above embodiment did, still belong to the protection domain of technical scheme of the present invention according to technical spirit of the present invention.
Claims (8)
- One kind the prevention and the treatment recurrent aphtha Chinese medicine; It is characterized in that, comprising: Radix Adenophorae, Fructus Evodiae, Cortex Cinnamomi, Rhizoma Et Radix Notopterygii, Aloe, Indigo Naturalis, Galla Chinensis, Fructus Corni, Herba Cistanches, Herba Hedyotidis Diffusae, Radix Sophorae Flavescentis, Radix Polygalae, Fructus Mume, Rhizoma Coptidis, Semen Plantaginis, Folium Sennae, Radix Puerariae, Fructus Lycii, Radix Rehmanniae, Cortex Moutan, Radix Glycyrrhizae and the Rhizoma Atractylodis Macrocephalae.
- 2. Chinese medicine as claimed in claim 1 is characterized in that: the ratio of weight and number of various components can be Radix Adenophorae 20～25 weight portions, Fructus Evodiae 12～16 weight portions, Cortex Cinnamomi 6～10 weight portions, Rhizoma Et Radix Notopterygii 10～15 weight portions, Aloe 25～35 weight portions, Indigo Naturalis 30～40 weight portions, Galla Chinensis 10～15 weight portions, Fructus Corni 17～23 weight portions, Herba Cistanches 12～18 weight portions, Herba Hedyotidis Diffusae 20～25 weight portions, Radix Sophorae Flavescentis 20～25 weight portions, Radix Polygalae 8～12 weight portions, Fructus Mume 18～22 weight portions, Rhizoma Coptidis 60～70 weight portions, Semen Plantaginis 15～20 weight portions, Folium Sennae 13～17 weight portions, Radix Puerariae 10～15 weight portions, Fructus Lycii 20～25 weight portions, Radix Rehmanniae 25～35 weight portions, Cortex Moutan 25～35 weight portions, Radix Glycyrrhizae 25～30 weight portions and the Rhizoma Atractylodis Macrocephalae 20～25 weight portions.
- 3. according to claim 1 or claim 2 Chinese medicine, it is characterized in that: the ratio of weight and number of various components can be Radix Adenophorae 22～25 weight portions, Fructus Evodiae 14～16 weight portions, Cortex Cinnamomi 8～10 weight portions, Rhizoma Et Radix Notopterygii 12～15 weight portions, Aloe 30～35 weight portions, Indigo Naturalis 35～40 weight portions, Galla Chinensis 12～15 weight portions, Fructus Corni 20～23 weight portions, Herba Cistanches 15～18 weight portions, Herba Hedyotidis Diffusae 22～25 weight portions, Radix Sophorae Flavescentis 22～25 weight portions, Radix Polygalae 10～12 weight portions, Fructus Mume 20～22 weight portions, Rhizoma Coptidis 65～70 weight portions, Semen Plantaginis 18～20 weight portions, Folium Sennae 15～17 weight portions, Radix Puerariae 12～15 weight portions, Fructus Lycii 22～25 weight portions, Radix Rehmanniae 30～35 weight portions, Cortex Moutan 30～35 weight portions, Radix Glycyrrhizae 27～30 weight portions and the Rhizoma Atractylodis Macrocephalae 22～25 weight portions.
- 4. like the described Chinese medicine of claim 1 to 3, it is characterized in that: also contain Radix Trichosanthis in the said Chinese medicine, the ratio of weight and number of said Radix Trichosanthis in said Chinese medicine is Radix Trichosanthis 6～10 weight portions.
- 5. the described Chinese medicine of claim 1 to 4, it is characterized in that: the dosage form of said Chinese medicine is capsule, spray or paster.
- 6. the described preparation method of Chinese medicine of claim 1 to 5 is characterized in that:When the dosage form of said Chinese medicine was capsule, it comprised,The first step; With said component proportional mixing, to add determining alcohol be that 80%～90% alcohol heating reflux extracts 2～4 times, and the extracting solution that obtains is merged, filter; Concentrating under reduced pressure; Remove the ethanol of mass percent 80%～90%, obtain concentrated solution, the alcoholic acid quality that is added is 2～4 times of mixture quality;In second step, above-mentioned concentrated solution is through macroporous adsorptive resins, and elder generation is with the deionized water or the distilled water eluting of 3～5 times of resin column volumes; The determining alcohol of 2～4 times of resin column volumes of reuse is 90%～95% ethanol elution, collects ethanol elution, and concentrating under reduced pressure becomes thick paste; Dry; Be ground into fine powder, sieve, obtain 50 orders～100 purpose fine powders;The 3rd step with the fine powder that obtains and starch, magnesium stearate stirring and evenly mixing, incapsulated the acquisition capsule, and with respect to the fine powder of 100 weight portions, the addition of said starch is 20～30 weight portions, and the addition of magnesium stearate is 0.5～2 weight portion.
- 7. the described preparation method of Chinese medicine of claim 1 to 5 is characterized in that:When the dosage form of said Chinese medicine was spray, it comprised,The first step; With said component proportional mixing, to add determining alcohol be that 80%～90% alcohol heating reflux extracts 2～4 times, and the extracting solution that obtains is merged, filter; Concentrating under reduced pressure; Remove the ethanol of mass percent 80%～90%, obtain concentrated solution, the alcoholic acid quality that is added is 2～4 times of mixture quality;In second step, above-mentioned concentrated solution is through macroporous adsorptive resins, and elder generation is with the deionized water or the distilled water eluting of 3～5 times of resin column volumes; The determining alcohol of 2～4 times of resin column volumes of reuse is 90%～95% ethanol elution, collects ethanol elution, and concentrating under reduced pressure becomes thick paste; Dry; Be ground into fine powder, sieve, obtain 50 orders～100 purpose fine powders;The 3rd step went on foot the fine powder that obtains with respect to second of 100 weight portions, with 50～200 weight portion distilled water dilutings, poured into spray bottle, made spray.
- 8. the described preparation method of Chinese medicine of claim 1 to 5 is characterized in that:When the dosage form of said Chinese medicine was paster, it comprised:The first step; With said component proportional mixing, to add determining alcohol be that 80%～90% alcohol heating reflux extracts 2～4 times, and the extracting solution that obtains is merged, filter; Concentrating under reduced pressure; Remove the ethanol of mass percent 80%～90%, obtain concentrated solution, the alcoholic acid quality that is added is 2～4 times of mixture quality;In second step, above-mentioned concentrated solution is through macroporous adsorptive resins, and elder generation is with the deionized water or the distilled water eluting of 3～5 times of resin column volumes; The determining alcohol of 2～4 times of resin column volumes of reuse is 90%～95% ethanol elution, collects ethanol elution, and concentrating under reduced pressure becomes thick paste; Dry; Be ground into fine powder, sieve, obtain 50 orders～100 purpose fine powders;The 3rd step was ground into smalls with pulverizer respectively with hydroxypropyl emthylcellulose binding agent and excipient magnesium stearate, sieved respectively, obtained 50 orders～100 purpose fine powders;The 4th step went on foot the material and the 3rd that obtains that sieves with second and goes on foot the material mix homogeneously that sieves and obtain, and was pressed into paster.
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| CN1519009A (en) * | 2003-01-24 | 2004-08-11 | 李彩凤 | Medication for treating ulcer of oral cavity and preparation method |
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| CN102309706A (en) * | 2011-09-07 | 2012-01-11 | 王旭日 | Traditional Chinese medicinal preparation for treating periodontitis |
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2012
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|---|---|---|---|---|
| CN1519009A (en) * | 2003-01-24 | 2004-08-11 | 李彩凤 | Medication for treating ulcer of oral cavity and preparation method |
| CN1579433A (en) * | 2003-07-30 | 2005-02-16 | 王毅 | Traditional Chinese medicine composition for treating mouth ulcer |
| CN1562232A (en) * | 2004-03-18 | 2005-01-12 | 胡德 | Medication for curing ulcerationd of oral cavity |
| CN102309706A (en) * | 2011-09-07 | 2012-01-11 | 王旭日 | Traditional Chinese medicinal preparation for treating periodontitis |
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