CN1562232A

CN1562232A - Medication for curing ulcerationd of oral cavity

Info

Publication number: CN1562232A
Application number: CN 200410023022
Authority: CN
Inventors: 胡德
Original assignee: Individual
Current assignee: Individual
Priority date: 2004-03-18
Filing date: 2004-03-18
Publication date: 2005-01-12
Anticipated expiration: 2024-03-18
Also published as: CN1277573C

Abstract

A Chinese medicine for treating oral ulcer is prepared from 17 Chinese-medicinal materials including asparagus root, liquorice root, honey, astragalus root, etc.

Description

A kind of medicine for the treatment of oral ulcer

One, technical field:

The present invention relates to a kind of medicine for the treatment of oral ulcer.

Two, background technology:

Recurrent oral ulceration is a kind of common chronic disease of cari oris mucosa, to occur outbreak periodically repeatedly on the oral mucosa, to have having an intense pain and self limiting ulcer is characteristics.Good sending out in lip, tongue, gingiva and buccal mucosa, outbreak rises one after another repeatedly, or the time when sending out more, course of disease delay, patient is very painful.

The medicine for the treatment of oral ulcer in the market is broadly divided into three major types, promptly oral medicine, contain take medicine, medicine for external use.Common oral medicine is divided into anti-inflammatory agent, antiviral agents and Chinese patent medicine class on the market.Anti-inflammatory agent is an antibiolics, as ampicillin capsule, Amoxicillin Capsules etc.Antiviral agents such as Ah former times Lip river reed sheet, sharp Ba Wei forest tract etc.More than two class medicines all belong to Western medicine, be not the medicine of specially treating dental ulcer, therapeutic effect is not obvious, side effect is many.The Chinese patent medicine class: as cow-bezoar antiphlogistic tablet, its composition is made up of Calculus Bovis, Radix Et Rhizoma Rhei, Indigo Naturalis, Venenum Bufonis, Realgar, Concha Margaritifera, Radix Trichosanthis.Qinghuozhimaipian and for example, its composition is by forming Herba Andrographis, Fructus Gardeniae, Radix Ophiopogonis, and this type of Chinese patent medicine is not the specially treating dental ulcer medicine, its unsatisfactory curative effect.Temporarily do not see the medicine of pure Chinese medicinal preparation treatment oral ulcer on the market.

Common containing taken medicine on the market, and as cydiodine, Herba Pileae Scriptae Tabellae etc., this type of medicine is cool taste when buccal only, and its therapeutic effect is not good.Chlorhexidine benzocaine buccal tablet and for example, its composition is made up of Cidex-7 chlorhexidine and narcotic analgesic medicine benzocaine composition, cures the symptoms, not the disease, can only buccal, ethanol sample poisoning symptom can appear if swallow.Rinsing the mouth medicine such as mouth Thailand, its composition is made up of metronidazole and Cidex-7 chlorhexidine, can only can not take orally by rinsing the mouth, ethanol sample poisoning symptom and stomach symptom can occur if wrongly take.This medicine take stopgap measures still can, permanent curing action is not good.

Common medicine for external use on the market, comply with one's wishes and to paste, its composition mainly is a dexamethasone acetate, belong to amcinonide, local external application takes stopgap measures but does not effect a permanent cure, and this type of medicine belongs to hormones, side effect is big, and serious active tuberculosis, hypertension, diabetes, stomach or duodenal ulcer, osteoporosis, early pregnancy, corneal ulcer and spiritedness medical history, epilepsy medical history, glaucoma and severe cardiac renal insufficiency person forbidding are arranged.The unsuitable life-time service of this product.

Three, summary of the invention:

The object of the present invention is to provide a kind of medicine for the treatment of oral ulcer.

Technical scheme of the present invention is: a kind of medicine for the treatment of oral ulcer, by Radix Asparagi, Radix Ophiopogonis, the Radix Rehmanniae, Radix Rehmanniae Preparata, Herba Dendrobii, mattress is, Fructus Aurantii, Radix Glycyrrhizae, Radix Scutellariae, Rhizoma Coptidis, Rhizoma Cimicifugae, Cortex Moutan, Mel, Radix Astragali, Fructus Corni, give birth to Folium Eriobotryae, Fructus Ligustri Lucidi is formulated in proportion, and its percentage by weight is: Radix Asparagi 4～7%, Radix Ophiopogonis 4～7%, the Radix Rehmanniae 5～8%, Radix Rehmanniae Preparata 5～7%, Herba Dendrobii 5～8%, mattress is 9～12%, Fructus Aurantii 3～6%, Radix Glycyrrhizae 5～8%, Radix Scutellariae 7～10%, Rhizoma Coptidis 1～4%, Rhizoma Cimicifugae 1～4%, Cortex Moutan 2～5%, Mel 9～12%, Radix Astragali 9～12%, Fructus Corni 2～5%, give birth to Folium Eriobotryae 11～14%, Fructus Ligustri Lucidi 2～5%.

Decocting method of the present invention is: all prescription medicines adopt all that the high-quality decoction pieces is selected to form, after 1: 4 clear water soaks 8～12 minutes with all prepared slices of Chinese crude drugs by weight, with big fire decoct boil to water after, the little fire of reuse continues to decoct 15～20 minutes, makes concentrated medicament.

Instructions of taking of the present invention is: with the concentrated medicament of making, per 2 hours of daytime, clothes were 1 time, and each 30ml is under buccal was obeyed after 10 minutes in the oral cavity earlier.10 days is a course of treatment.

It is relevant with psychentonia, endocrine regulation, virus, bacterial infection that recurrent oral ulceration sickness rate height, modern medicine study are thought.Its cause of disease is not clear and definite as yet, has the scholar to think relevant with immunologic mechanism.Primary disease belongs to categories such as medical science " aphtha ", " aphtha ", " mouthful infections ", " oral-anal-genital ulcer syndrome ".Among the present invention: Radix Asparagi, Radix Ophiopogonis, the Radix Rehmanniae, Herba Dendrobii heat clearing away nourishing YIN.The clear away heart-fire heresy of stomach-fire of Radix Scutellariae, Rhizoma Coptidis.The Rhizoma Cimicifugae priming is up.Radix Rehmanniae Preparata, Fructus Ligustri Lucidi, Cortex Moutan, Fructus Corni nourishing kidney yin, nourishing and do not stay heresy is fallen and is let out and just do not hinder.Radix Astragali, Mel QI invigorating poison holding, expelling pus and promoting granulation adds the medicine of nourishing kidney yin, and the effect with human body immunity improving function reduces recurrence.

Use Drug therapy recurrent oral ulceration of the present invention, obtained significant curative effect.Now 388 routine clinical observation test effects are summarized as follows: 1, clinical data 1.1 physical data are originally organized in 388 examples, male 168 examples, women 220 examples, age reckling 5 years old, the maximum 68 years old, 42 years old mean age.The elder of the course of disease 10 years, the shortest person 2 years.At least repeatedly show effect every year more than 10 times, with the mandibular lymph node person of swelling and ache 106 examples.1.2 shallow table is arranged on the diagnostic criteria oral mucosa, ulcer point as Semen Glycines or Semen phaseoli radiati size, good sending out in lacking cuticular layer and the relatively poor zone of keratinization, be more common in positions such as lip inboard, the tip of the tongue, lingual margin, buccal mucosa, gingiva place, from the beginning of being very thin small red dot, with scorching hot sense of discomfort, and expand as about 2-3mm of diameter or bigger fester gradually.Ulcer place nick, the faint yellow pseudomembrane of surface coverage one deck, mucous hyperemia is the blush shape around the ulcer, and causalgia is obvious.2, Therapeutic Method: the present invention mainly by Radix Asparagi, Radix Ophiopogonis, the Radix Rehmanniae, Radix Rehmanniae Preparata, Herba Dendrobii, mattress be, Fructus Aurantii, Radix Glycyrrhizae, Radix Scutellariae, Rhizoma Coptidis, Rhizoma Cimicifugae, Cortex Moutan, Mel, Radix Astragali, Fructus Corni, give birth to Folium Eriobotryae, Fructus Ligustri Lucidi is formulated in proportion, makes concentrated liquid through Drug Manufacturing Room.Every bottle of 500ml, per 2 hours of daytime obeyed once, and per 6 hours of evening obeyed once, obeyed 30ml at every turn, under buccal is obeyed after 10 minutes again in the oral cavity earlier, serve on 10 days, was a course of treatment.3, observation of curative effect 3.1 criterions of therapeutical effect recovery from illness: ulcer heal in 5 days, and recurrence is not seen in General Symptoms disappearance, drug withdrawal later six months.Effectively: ulcer healing in a week, General Symptoms disappears, and in drug withdrawal later six months, idol has and recurs 1 time.Invalid: ulcer is healing person after 10 days, outbreak repeatedly after the healing, and seizure frequency is with the last sample of treatment.3.2 therapeutic outcome is originally organized in 388 examples, 318 examples of fully recovering account for 82%; Effective 70 examples account for 18%; Total effective rate 100%.Medical record is given an example: Chen, and the woman 32 years old, suffered from oral ulcer 4 years, the dispute mucosa has many places ulcer, does not touchingly heal repeatedly, never interrupts, certain department of stomatology, Hospital is diagnosed as the recurrent oral cavity, many places integrative therapy once, and antibiotics, metronidazole, vitamin are repeatly with not imitating; The folk prescription of personal at ordinary times each biostearin and heat-clearing and toxic substances removing, medical herbs are also to no effect.Examining its oral mucosa and lingual surface during prescription on individual diagnosis respectively has the ulcer of 3 place's Semen phaseoli radiatis, Semen Glycines size, and skin ulcer face depression is turned white, red and swollen all around, private prosecution causalgia, xerostomia, red tongue, few tongue, the little string of thready pulse.After 5 days, pain disappears through clothes the present invention, the ulcer surface healing.For consolidating curative effect, obey two courses of treatment altogether.Visit so far, do not see recurrence.The king so-and-so, the woman, 53 years old, the chronic stomatocace 6 years of showing effect repeatedly was surplus, surplus the annual outbreak 20 time, saw the tip of the tongue and two buccal mucosa many places ulcer during prescription on individual diagnosis, Semen Glycines size approximately, sharp ache.The companion is dizzy, and the soreness of waist is weak, and diet reduces, red tongue, deep-thready pulse.After 3 days, pain relief was obeyed after 5 days through clothes the present invention, the ulcer surface healing.For consolidating curative effect, obey two courses of treatment altogether.Visit so far, do not see recurrence.

Four, the specific embodiment:

Embodiment 1: take by weighing Radix Asparagi 15 gram, Radix Ophiopogonis 15 grams, the Radix Rehmanniae 18 grams, Radix Rehmanniae Preparata 18 grams, Herba Dendrobii 18 grams, mattress respectively and be 30 grams, Fructus Aurantii 12 grams, Radix Glycyrrhizae 18 grams, Radix Scutellariae 24 grams, Rhizoma Coptidis 6 grams, Rhizoma Cimicifugae 6 grams, Cortex Moutan 9 grams, Mel 28 grams, Radix Astragali 30 grams, Fructus Corni 9 grams, give birth to Folium Eriobotryae 36 grams, Fructus Ligustri Lucidi 8 grams, after with the clear water of 1200ml all prepared slices of Chinese crude drugs being soaked 8～12 minutes, with big fire decoct boil to water after, the little fire of reuse continues to decoct 15～20 minutes, makes concentrated liquid.

Embodiment 2: take by weighing Radix Asparagi 15kg, Radix Ophiopogonis 15kg, Radix Rehmanniae 18kg, Radix Rehmanniae Preparata 18kg, Herba Dendrobii 15kg respectively, mattress is 28kg, Fructus Aurantii 10kg, Radix Glycyrrhizae 15kg, Radix Scutellariae 20kg, Rhizoma Coptidis 5kg, Rhizoma Cimicifugae 5kg, Cortex Moutan 6kg, Mel 28kg, Radix Astragali 28kg, Fructus Corni 6kg, gives birth to Folium Eriobotryae 36kg, Fructus Ligustri Lucidi 8kg, after with the clear water of 1200kg all prepared slices of Chinese crude drugs being soaked 8～12 minutes, with big fire decoct boil to water after, the little fire of reuse continues to decoct 15～20 minutes, makes concentrated liquid.

Claims

1, a kind of medicine for the treatment of oral ulcer, it is characterized in that: by Radix Asparagi, Radix Ophiopogonis, the Radix Rehmanniae, Radix Rehmanniae Preparata, Herba Dendrobii, mattress is, Fructus Aurantii, Radix Glycyrrhizae, Radix Scutellariae, Rhizoma Coptidis, Rhizoma Cimicifugae, Cortex Moutan, Mel, Radix Astragali, Fructus Corni, give birth to Folium Eriobotryae, Fructus Ligustri Lucidi is formulated in proportion, and its percentage by weight is: Radix Asparagi 4～7%, Radix Ophiopogonis 4～7%, the Radix Rehmanniae 5～8%, Radix Rehmanniae Preparata 5～7%, Herba Dendrobii 5～8%, mattress is 9～12%, Fructus Aurantii 3～6%, Radix Glycyrrhizae 5～8%, Radix Scutellariae 7～10%, Rhizoma Coptidis 1～4%, Rhizoma Cimicifugae 1～4%, Cortex Moutan 2～5%, Mel 9～12%, Radix Astragali 9～12%, Fructus Corni 2～5%, give birth to Folium Eriobotryae 11～14%, Fructus Ligustri Lucidi 2～5%.

2, the medicine of treatment oral ulcer according to claim 1, it is characterized in that: its decocting method is: all prescription medicines adopt all that the high-quality decoction pieces is selected to form, after 1: 4 clear water soaks 8～12 minutes with all prepared slices of Chinese crude drugs by weight, with big fire decoct boil to water after, the little fire of reuse continues to decoct 15～20 minutes, makes concentrated medicament.

3, the medicine of treatment oral ulcer according to claim 1 and 2 is characterized in that: the instructions of taking of this medicine is: with the concentrated medicament of making, per 2 hours of daytime, clothes were 1 time, and each 30ml is under buccal was obeyed after 10 minutes in the oral cavity earlier.10 days is a course of treatment.