CN103495048A - Traditional Chinese medicine composition for treating children's aphthous stomatitis - Google Patents

Abstract

A traditional Chinese medicine composition for treating children's aphthous stomatitis relates to the technical field of Chinese herbal medicines, and is a medicament prepared from the following bulk drugs in parts by weight: 29-31 parts of raw rehmannia root, 8-10 parts of akebia stem, 8-10 parts of bamboo leaves, 8-10 parts of coptis, 8-10 parts of radix scutellariae, 8-10 parts of forsythia suspense and 5-7 parts of licorice tail. The traditional Chinese medicine composition is accord with traditional Chinese medicine syndrome differentiation theory on traditional Chinese medicinal material selection and compatibility; and the traditional Chinese medicine composition has the advantages of simple preparation method, fast effectiveness, high cure rate, uneasiness in recurrence and the like.

Description

A kind of Chinese medicine composition that is used for the treatment of children's's aphtha of the mouth and tongue

Technical field

The present invention relates to field of Chinese herbal medicine technology, be specifically related to a kind of Chinese medicine composition of the children's's of being used for the treatment of aphtha of the mouth and tongue.

Background technology

Aphtha of the mouth and tongue or fester, occur the oral pathology of local pain.Some patients were Chang Fanfu outbreak, even ulcer disunion of a specified duration.How by accumulation of heat in the heart and spleen, diseases caused by exogenous pathogenic factor pathogenic heat, or damp-heat in the spleen and stomach, due to hyperactivity of YANG due to deficiency of YIN.In ancient literature, claiming again this sick is mouthful broken, aphtha, mouthful infections, occurs in the title tongue infections of tongue.The oral ulcer that is equivalent to doctor trained in Western medicine.Skin infection all belongs to fire, but the difference of excess-fire and asthenic fire is arranged, and as because tobacco and wine do not save, or polyphagia delicious food savoury, the heat-dissipating of being detained, or affection due to external wind and heat, damp and hot heresy, enter inner fire-transformation, or the pent-up of feelings will, of a specified duration and fire-transformation, how true fire.

Summary of the invention

Technical problem to be solved by this invention is to provide a kind of cure rate high, the safe and reliable Chinese medicine composition that is used for the treatment of children's's aphtha of the mouth and tongue.

Technical problem to be solved by this invention realizes by the following technical solutions:

A kind of Chinese medicine composition that is used for the treatment of children's's aphtha of the mouth and tongue, the medicament of being made by the crude drug of following weight portion,

Radix Rehmanniae 29-31 part, Caulis Akebiae 8-10 part, Folium Bambusae 8-10 part, Rhizoma Coptidis 8-10 part, Radix Scutellariae 8-10 part, Fructus Forsythiae 8-10 part, Radix Glycyrrhizae be 5-7 part slightly.

Preferred weight part of each crude drug is:

30 parts, the Radix Rehmanniae, 9 parts of Caulis Akebiaes, 9 parts, Folium Bambusae, 9 parts of Rhizoma Coptidis, 9 parts of Radix Scutellariaes, 9 parts of Fructus Forsythiaes, slightly 6 parts, Radix Glycyrrhizae.

The present invention's crude drug used can be bought and obtain from the common Chinese shop, and its specification meets national Chinese crude drug standard and gets final product.

Chinese medicine composition of the present invention can add various adjuvants required while preparing different dosage form, such as disintegrating agent, lubricant, adhesive etc., be prepared into any oral formulations commonly used with conventional method of Chinese medicinal, wherein, described oral formulations can be decoction, pill, capsule or tablet.

Another object of the present invention is to provide a kind of method for preparing the present composition, comprises the steps,

1) take each crude drug by the prescription parts by weight: 30 parts, the Radix Rehmanniae, 9 parts of Caulis Akebiaes, 9 parts, Folium Bambusae, 9 parts of Rhizoma Coptidis, 9 parts of Radix Scutellariaes, 9 parts of Fructus Forsythiaes, slightly 6 parts, Radix Glycyrrhizae;

2) the above-mentioned material medicine of respectively distinguishing the flavor of is mixed be placed in marmite and add water and do not have powder, after soaking 20 ~ 40 minutes, use slow fire boiling, after boiling, renew and decoct 30 minutes, decoct altogether three times, merge three decocting liquids and filter, obtain decoction.

1, pharmacology analysis:

The Radix Rehmanniae: clearing away heat and cooling blood, yin nourishing, promote the production of body fluid.

Caulis Akebiae: hardship, cold.GUIXIN, small intestinal, urinary bladder channel.Inducing diuresis for treating stranguria syndrome, clearing away heart-fire.The Changzhi flaming up of heart-fire, aphtha of the mouth and tongue.

Folium Bambusae: sweet suffering is light cold, enters heart stomach-intestinal warp.Clearing heat and relieving fidgetness, the diuresis of promoting the production of body fluid.Control the calentura excessive thirst, the erosion of the oral mucosa tongue boil.

Rhizoma Coptidis: hardship, cold, nontoxic.GUIXIN, spleen, stomach, liver, gallbladder, large intestine channel.Heat clearing and damp drying, eliminating fire and detoxication.

Radix Scutellariae: heat clearing and damp drying is arranged, and removing heat from blood is antiabortive, detoxicating functions.Cure mainly epidemic febrile disease, upper respiratory tract infection, cough due to lung-heat, damp and hot jaundice, pneumonia, dysentery, hemoptysis.

Fructus Forsythiae: hardship is slightly cold.Return lung, the heart, gallbladder meridian.Cure mainly calentura from the beginning of, anemopyretic cold, heating, vexed, laryngopharynx swelling and pain.

Radix Glycyrrhizae is slightly: sweet in the mouth, property is flat, nontoxic.Heat-clearing and toxic substances removing, nourishing the lung to arrest cough.

2, usage and consumption:

The dosage of medicine of the present invention depends on concrete dosage form, and the factor such as age of patient, body weight, health status.Instruction: decoction, get an auxiliary medicine, decoct into decoction, every day one, pair, 2 days be a course for the treatment of, is applicable to 1 above children taking of one full year of life.

3, the present composition has carried out a large amount of clinical trials of a large amount of animal acute toxicity tests, long-term toxicity test for animals and treatment disease, and the use link that this medicine is dropped into to the treatment disease provides science and objective foundation.Its test method and result of the test are as follows respectively:

1) decoction prepared by the present invention carries out animal acute toxicity test:

Medicine: the present invention's crude drug used is bought and is obtained from the common Chinese shop, and its specification meets national Chinese crude drug standard.

Experimental animal: white mice, body weight is in the 50g left and right, and male and female are selected at random, by market, are bought.

Method and result: get 30 of white mice, hungry about 20 hours, feed 50ml by filling with several times every every day, feed one week continuously, to observe 10 days, mice is movable normal, and non-toxic reaction, without dead.Show that oral liquid is without acute toxicity, clinical medicine dose safety.

2) decoction prepared by the present invention carries out long-term toxicity test for animals:

Experimental animal: rat, body weight is at 120-130g, and male and female are selected at random, by market, are bought.

Method and result: get 20 of rat, be divided into 2 groups, every group 10, wherein the 1st group as the administration group, feed 30-40ml by filling with several times every every day, the 2nd group of normal feeding as a control group, once a day, continuous irrigation is fed 90 days, survey body weight, 24 hours sacrificed by decapitation after last administration, survey blood, routine urinalysis, liver function, renal function, core, the internal organs such as kidney, the variation of tissues observed form, observe the effect of dosage, observe diet, movable variation, experimental results show that administration group and matched group are relatively without significant change, equal non-toxic reaction, a kind of safe drugs.

4, clinical diagnosis

1) in order to verify clinical efficacy, this prescription is tried out in Anhui Province the first Affiliated Hospital of Chinese medicine institute respectively, chooses at random wherein 50 routine patients.

2) Therapeutic Method: according to drug ratios of the present invention, take raw material (dosage), according to the method for decocting medicinal herbs usually, make decoction, every day one pair, taking 2 days is a course for the treatment of, the shortest 1 course for the treatment of, the longest 3 courses for the treatment of.

3) efficacy determination:

Recovery from illness: painless, the open sore part all disappears, and does not affect normally diet at ordinary times; Produce effects: painless, the open sore part obviously diminishes, and does not affect normally diet at ordinary times; Effectively: pain significantly reduces, and the open sore part diminishes, and the energy diet, occasionally have discomfort, can accept; Invalid: as to treat rear symptom, sign and compare before treatment without any change; Concrete therapeutic outcome is referring to table 1.

Table 1

Number of cases	Recovery from illness	Produce effects	Effectively	Invalid	Effective percentage (%)
						50	5	30	10	5	90

5, points for attention:

1. diet should be light, gives up alcohol and pungent, raw and cold, greasy food.

2. strictly by usage and dosage, take, this medicine should not be taken for a long time in a large number.

3. to this medicine and ethanol allergy sufferers forbidding, allergic constitution the person be cautious use of.

4. when this property of drug changes, ban use of.

5. this medicine please be placed on to the place that the child can not contact.

6. as use other medicines, using please Ref Dr or pharmacist before this medicine.

The invention has the beneficial effects as follows: the present invention Chinese crude drug select and compatibility on meet the Chinese medical discrimination theory, and compound method is simple, has rapid-actionly, cure rate is high, the advantages such as difficult recurrence.

The specific embodiment

For technological means, creation characteristic that the present invention is realized, reach purpose and effect is easy to understand, below in conjunction with specific embodiment, further set forth the present invention.

Embodiment 1

Radix Rehmanniae 30g, Caulis Akebiae 9g, Folium Bambusae 9g, Rhizoma Coptidis 9g, Radix Scutellariae 9g, Fructus Forsythiae 9g, Radix Glycyrrhizae be 6g slightly.The above-mentioned material medicine of respectively distinguishing the flavor of is mixed to be placed in marmite add water and do not have powder, after soaking 20 ~ 40 minutes, use slow fire boiling, after boiling, renew and decoct 30 minutes, decoct altogether three times, merge three decocting liquids and filter, obtain decoction.Every day one, pair, 2 days be a course for the treatment of.

Embodiment 2

Radix Rehmanniae 31g, Caulis Akebiae 10g, Folium Bambusae 10g, Rhizoma Coptidis 10g, Radix Scutellariae 10g, Fructus Forsythiae 10g, Radix Glycyrrhizae be 7g slightly.The above-mentioned material medicine of respectively distinguishing the flavor of is mixed to be placed in marmite add water and do not have powder, after soaking 20 ~ 40 minutes, use slow fire boiling, after boiling, renew and decoct 30 minutes, decoct altogether three times, merge three decocting liquids and filter, obtain decoction.Every day one, pair, 2 days be a course for the treatment of.

Embodiment 3

Radix Rehmanniae 29g, Caulis Akebiae 8g, Folium Bambusae 8g, Rhizoma Coptidis 8g, Radix Scutellariae 8g, Fructus Forsythiae 8g, Radix Glycyrrhizae be 5g slightly.The above-mentioned material medicine of respectively distinguishing the flavor of is mixed to be placed in marmite add water and do not have powder, after soaking 20 ~ 40 minutes, use slow fire boiling, after boiling, renew and decoct 30 minutes, decoct altogether three times, merge three decocting liquids and filter, obtain decoction.Every day one, pair, 2 days be a course for the treatment of.

Model case:

Case 1

Cao, man, 6 years old, road, grain husk South Street, Jieshou City, Anhui Province.There are several pieces of 0.2-0.5 centimetre ulcer in the patient oral cavity, and pain endlessly, dare not be taken food, and cries and screams all day and does not stop.Take continuously after the present invention writes out a prescription 2 days, pain symptom obviously alleviates.After take continuously again and consolidated in 4 days, ulcer all disappears, recovery from illness.Follow up a case by regular visits to half a year, not recurrence.

Case 2

Liu so-and-so, man, 8 years old, Tao Miao people from town, Jieshou City, Anhui Province.There is red exanthema vesiculosum in patient's lip section, and surrounding is congested and be red and swollen, and pain can not be eaten food.Take this prescription 4 days, symptom disappears fully, and diet is normal, follows up a case by regular visits to 1 year, does not recur again.

Case 3

Still so-and-so, female, 9 years old, Guang Wu people from town, Jieshou City, Anhui Province.Patient's perleche, dry and cracked, aphtha of the mouth and tongue, used vitamin C, has no improvement.After take the decoction of formula preparation of the present invention, after 3 days, symptom starts to take a turn for the better, and can have a meal, pain no longer, continue to take 4 days afterwards, recovery from illness.

Above demonstration and described ultimate principle of the present invention and principal character and advantage of the present invention.The technical staff of the industry should understand; the present invention is not restricted to the described embodiments; that in above-described embodiment and description, describes just illustrates principle of the present invention; without departing from the spirit and scope of the present invention; the present invention also has various changes and modifications, and these changes and improvements all fall in the claimed scope of the invention.The claimed scope of the present invention is defined by appending claims and equivalent thereof.

Claims (7)

1. a Chinese medicine composition that is used for the treatment of children's's aphtha of the mouth and tongue is characterized in that: the medicament of being made by the crude drug of following weight portion,

Radix Rehmanniae 29-31 part, Caulis Akebiae 8-10 part, Folium Bambusae 8-10 part, Rhizoma Coptidis 8-10 part, Radix Scutellariae 8-10 part, Fructus Forsythiae 8-10 part, Radix Glycyrrhizae be 5-7 part slightly.

2. a kind of Chinese medicine composition that is used for the treatment of children's's aphtha of the mouth and tongue according to claim 1 is characterized in that: the medicament of being made by the crude drug of following weight portion,

30 parts, the Radix Rehmanniae, 9 parts of Caulis Akebiaes, 9 parts, Folium Bambusae, 9 parts of Rhizoma Coptidis, 9 parts of Radix Scutellariaes, 9 parts of Fructus Forsythiaes, slightly 6 parts, Radix Glycyrrhizae.

3. a kind of Chinese medicine composition that is used for the treatment of children's's aphtha of the mouth and tongue according to claim 1 and 2 is characterized in that: described medicament is any suitable preparation clinically.

4. a kind of Chinese medicine composition that is used for the treatment of children's's aphtha of the mouth and tongue according to claim 3, it is characterized in that: described preparation is oral formulations.

5. a kind of Chinese medicine composition that is used for the treatment of children's's aphtha of the mouth and tongue according to claim 4, it is characterized in that: described oral formulations is decoction.

6. a method for preparing claim 1 or the described Chinese medicine composition of 2 any one is characterized in that: comprises the following steps,

1) take each crude drug by the prescription parts by weight;

2) the above-mentioned material medicine of respectively distinguishing the flavor of is mixed be placed in marmite and add water and do not have powder, after soaking 20 ~ 40 minutes, use slow fire boiling, after boiling, renew and decoct 30 minutes, decoct altogether three times, merge three decocting liquids and filter, obtain decoction.

7. the purposes in treatment children's aphtha of the mouth and tongue medicine according to claim 1 or the described Chinese medicine composition of 2 any one.