CN103495016B - Traditional Chinese medicine composition for treating vexation and insomnia - Google Patents
Traditional Chinese medicine composition for treating vexation and insomnia Download PDFInfo
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Abstract
A traditional Chinese medicine composition for treating vexation and insomnia relates to the technical field of Chinese herbal medicines, and is a medicament prepared from the following bulk drugs in parts by weight: 8-10 parts of cape jasmine, 8-10 parts of radix paeoniae alba, 8-10 parts of fritillaria, 8-10 parts of radix puerariae, 11-13 parts of spina date seeds, 11-13 parts of white hyacinth bean and 8-10 parts of Chinese magnoliavine. The traditional Chinese medicine composition is accord with traditional Chinese medicine syndrome differentiation theory on traditional Chinese medicinal material selection and compatibility, has substantial treatment effect on patients who have sleep problems, has no toxic and side effects, and helps to reach the purpose of complementing each other in traditional Chinese medicine compatibility.
Description
Technical field
The present invention relates to field of Chinese herbal medicine technology, be specifically related to a kind of Chinese medicine composition being used for the treatment of vexed insomnia.
Background technology
Along with the quickening of people's rhythm of life, and from the pressure of the aspects such as society, family, make people be in a kind of fatigue state of anxiety within and mentally, in the course of time, just there will be insomnia, dizziness, headache, the symptom such as forgetful, weak.These symptoms all have an impact to the life of patient, work, study and inter personal contact, so that vicious cycle, and secondary anxiety, depression, hypochondriasis and fear etc., bring the misery on huge body & mind to patient.
Now clinically adopt some Western medicine tranquilizer, as Cure for insomnias such as stable, chlorpromazine, secobarbitals, along with the course of disease extends, dose also constantly increases, or needs to change the stronger calm medicine of effect more.The insomnia of Western medicine opioid therapy is the control of removing food stagnancy or forces sleep, can not improve sleep quality, and chemical tranquilizer is that people early have common recognition to toxic and side effects that is neural, internal organs.Have some Chinese patent medicines clinically now, as BUXIN DAN, Pill of Magnetitum and Cinnabari, Cinnabar Sedative Pill etc., but they do not obtain gratifying effect in curative effect yet.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of effective, the safe and reliable Chinese medicine composition being used for the treatment of vexed insomnia.
Technical problem to be solved by this invention realizes by the following technical solutions:
Be used for the treatment of a Chinese medicine composition for vexed insomnia, the medicament be made up of the crude drug of following weight portion,
Fructus Gardeniae 8-10 part, Radix Paeoniae Alba 8-10 part, Bulbus Fritillariae Thunbergii 8-10 part, Radix Puerariae 8-10 part, Semen Ziziphi Spinosae 11-13 part, Semen Lablab Album 11-13 part, Fructus Schisandrae Chinensis 8-10 part.
Preferred weight part of each crude drug is:
Fructus Gardeniae 9 parts, the Radix Paeoniae Alba 9 parts, Bulbus Fritillariae Thunbergii 9 parts, Radix Puerariae 9 parts, Semen Ziziphi Spinosae 12 parts, Semen Lablab Album 12 parts, Fructus Schisandrae Chinensis 9 parts.
Crude drug used by the present invention can be bought from common Chinese shop and obtain, and its specification meets national Chinese crude drug standard.
Another object of the present invention is to provide a kind of method preparing the present composition, comprises the steps,
1) each taste crude drug is taken by parts by weight described in prescription;
2) above-mentioned each taste material medicine is mixed being placed in marmite adds water did not have powder, soak after 30 minutes, with slow fire boiling, renew after boiling and decoct 30 minutes, decoct three times altogether, merges three decocting liquids filtrations, obtain decoction.
1, pharmacology analysis:
Fructus Gardeniae: bitter, cold, nontoxic.Pathogenic fire purging relieving restlessness; Clearing away heat-damp and promoting diuresis; Removing pathogenic heat from blood and toxic substance from the body; Fructus Gardeniae Preparatus: cooling blood for hemostasis.
The Radix Paeoniae Alba: acid, puts down and is slightly cold, slightly poisonous.Enter liver, spleen channel.Nourishing blood to suppress the hyperactive liver, pain relieving in slow, relieving restlessness of bringing down a fever, QI invigorating.
Bulbus Fritillariae Thunbergii: bitter, sweet, is slightly cold.Return lung, heart channel.There is the merit of eliminating stagnation dissipating depression of QI, the uncomfortable in chest vexed card for the treatment of caused by combination of phlegm and heat.
Radix Puerariae: cool in nature, sweet in the mouth, pungent.Expelling pathogenic factors from muscles is delivered: Radix Puerariae acetone extract makes temperature recovery act on normally, effective to multiple heating.Therefore it is thirsty to be usually used in heating, the diseases such as vexed uneasiness.
Semen Ziziphi Spinosae: sweet in the mouth, acid, property is put down.Can conscience be nourished, calm the nerves, arresting sweating.
Semen Lablab Album: sweet in the mouth, warm in nature, nontoxic.Spleen invigorating and in, removing dampness of relieving summer heat.
Fructus Schisandrae Chinensis: astringe the lung, nourishing kidney, promotes the production of body fluid, and receives antiperspirant, arresting seminal emission.
2, usage and consumption:
The dosage of medicine of the present invention depends on concrete dosage form, and the factor such as the age of patient, body weight, health status.Instruction: decoction: one day 2 times, a 200ml, sub-service sooner or later 7 days is a course for the treatment of.
3, the present composition has carried out a large amount of clinical trials of a large amount of animal acute toxicity tests, long-term toxicity test for animals and disease therapy, drops into the use link of disease therapy provide science and objective foundation to this medicine.Its test method and result of the test are distinguished as follows:
1) animal acute toxicity test is carried out to decoction prepared by the present invention:
Medicine: the crude drug used by the present invention is bought from common Chinese shop and obtained, and its specification meets national Chinese crude drug standard.
Experimental animal: white mice, body weight is at about 50g, and male and female Stochastic choice, is bought by market.
Method and result: get white mice 10, hungry 20 hours, fill with for 3 times by every only every natural gift and feed 20ml, feed one week continuously, observe 10 days, mice is movable normal, non-toxic reaction, without dead.Show that oral liquid is without acute toxicity, clinical medicine dose safety.
2) long-term toxicity test for animals is carried out to decoction prepared by the present invention:
Experimental animal: rat, body weight is at 120-130g, and male and female Stochastic choice, is bought by market.
Method and result: get rat 20, be divided into 2 groups, often organize 10, wherein the 1st group as administration group, feed by filling with for 2 times every every day, each 5-10ml, 2nd group of diet as a control group, once a day, continuous irrigation is fed 90 days, survey body weight, 24 hours sacrificed by decapitation after last administration, survey blood, routine urinalysis, liver function, renal function, core, the internal organs such as kidney, the change of tissues observed form, observe the effect of dosage, observe diet, movable change, experiment proves that administration group compares without significant change with matched group, equal non-toxic reaction, a kind of safe drugs.
4, diagnostic criteria
1) clinical diagnosis: toss about during sleep and have difficulty in going to sleep or dreaming often and waking easily, feelings will is not relaxed, depressed, deafness, dialectically to overtax one's nerves card for stagnation of liver-QI.Have difficulty in going to sleep, insomnia-middle, Yi Xing, dreaminess, early awakening, wake up after not easily sleep again.
2) in order to verify clinical efficacy, this prescription is tried out in Jieshou City, Anhui Province First People's Hospital respectively, the patient of random selecting wherein 50 routine poor sleeping quality.
3) Therapeutic Method: according to drug ratios of the present invention, takes raw material (dose), obtains medicinal liquid according to the method for usually boiling medicine, every day potion, sooner or later service once, taking 7 days is a course for the treatment of.The shortest 1 course for the treatment of, the longest 8 courses for the treatment of.
4) efficacy determination:
Recovery from illness: sleep disorder improves completely, and half an hour of going to bed can fall asleep, happy, spiritedness; Effective: sleep disorder and other symptom are significantly improved, and not easily wake up after sleeping, happy, spirit very well; Effective: sleep disorder and other symptom change, sometimes can wake up at night, but can accept; Invalid: to treat rear symptom, sign compared with before treatment without any change; Concrete therapeutic outcome is see table 1.
Table 1
| Number of cases | Recovery from illness | Effective | Effectively | Invalid | Effective percentage (%) |
| 50 | 15 | 20 | 10 | 5 | 90 |
5, points for attention:
1. diet should be light, gives up alcohol and pungent, raw and cold, greasy food.
2. child, women breast-feeding their children, elderly and infirm should take under doctor instructs.
3. driver, work high above the ground person are cautious use of.
4. strictly take by usage and dosage, this medicine should not be taken for a long time in a large number.
5. pair this medicine and alcohol intolerance person forbidding, allergic constitution person be cautious use of.
6. prohibit the use when this property of drug changes.
7. please this medicine is placed on the place that child can not contact.
8. as used other medicines, please Ref Dr or pharmacist before using this medicine.
The invention has the beneficial effects as follows: the present invention selects at Chinese crude drug and compatibility meets Chinese medical discrimination theory, to the patient Be very effective having sleeping problems, and has no side effect, reaches complementary object in drug matching.
Detailed description of the invention
The technological means realized to make the present invention, creation characteristic, reaching object and effect is easy to understand, below in conjunction with specific embodiment, setting forth the present invention further.
Embodiment 1
Each crude drug is taken: Fructus Gardeniae 9g, Radix Paeoniae Alba 9g, Bulbus Fritillariae Thunbergii 9g, Radix Puerariae 9g, Semen Ziziphi Spinosae 12g, Semen Lablab Album 12g, Fructus Schisandrae Chinensis 9g by following parts by weight.Above-mentioned each taste material medicine is mixed being placed in marmite adds water did not have powder, soak after 30 minutes, with slow fire boiling, renew after boiling and decoct 30 minutes, decoct three times altogether, merges three decocting liquids filtrations, obtain decoction.Every day potion, sooner or later service once, taking 7 days is a course for the treatment of.
Embodiment 2
Each crude drug is taken: Fructus Gardeniae 8g, Radix Paeoniae Alba 8g, Bulbus Fritillariae Thunbergii 8g, Radix Puerariae 8g, Semen Ziziphi Spinosae 11g, Semen Lablab Album 11g, Fructus Schisandrae Chinensis 8g by following parts by weight.Above-mentioned each taste material medicine is mixed being placed in marmite adds water did not have powder, soak after 30 minutes, with slow fire boiling, renew after boiling and decoct 30 minutes, decoct three times altogether, merges three decocting liquids filtrations, obtain decoction.Every day potion, sooner or later service once, taking 7 days is a course for the treatment of.
Embodiment 3
Each crude drug is taken: Fructus Gardeniae 10g, Radix Paeoniae Alba 10g, Bulbus Fritillariae Thunbergii 10g, Radix Puerariae 10g, Semen Ziziphi Spinosae 13g, Semen Lablab Album 13g, Fructus Schisandrae Chinensis 10g by following parts by weight.Above-mentioned each taste material medicine is mixed being placed in marmite adds water did not have powder, soak after 30 minutes, with slow fire boiling, renew after boiling and decoct 30 minutes, decoct three times altogether, merges three decocting liquids filtrations, obtain decoction.Every day potion, sooner or later service once, taking 7 days is a course for the treatment of.
Model case:
Case 1
Zhang, female, 59 years old, Fuyang City people from Lixin County, Anhui Province.Go to a doctor in The First Affiliated Hospital of Anhui College of Traditional Chinese Medicine, suffer from neurasthenia through tcm diagnosis, closely over the past half year because spiritual hypertonicity is insomniac, sometimes can not fall asleep whole night.After taking 2 courses for the treatment of of medicine of the present invention, the symptoms such as difficulty falling asleep take a favorable turn, and sleep can reach 4-6 hour every night; After taken again 4 courses for the treatment of continuously, the every inspection of further consultation is all normal, follows up a case by regular visits to 1 year without recurrence.
Case 2
Appoint so-and-so, man 63 years old, peasant, brick people from market town, Jieshou City, Anhui Province.Self blood fat is high, hypertension, has a sleepless night nearly 1 year, has difficulty in going to sleep, be easy to wake up with a start.After taking 8 courses for the treatment of of medicine of the present invention continuously, insomnia disappears completely, follows up a case by regular visits to 1 year without recurrence.
Case 3
Ma, female, 47 years old, enterprise staff, people from Funan County, Anhui Province.Comparatively tired at ordinary times, like worrying about when anything crops up, present interim insomnia.After taking 2 courses for the treatment of of medicine of the present invention continuously, can reach 6 hours the length of one's sleep every night, rear taking continuously is consolidated 3 courses for the treatment of, follows up a case by regular visits to 1 year without recurrence.
More than show and describe ultimate principle of the present invention and principal character and advantage of the present invention.The technical staff of the industry should understand; the present invention is not restricted to the described embodiments; what describe in above-described embodiment and description just illustrates principle of the present invention; without departing from the spirit and scope of the present invention; the present invention also has various changes and modifications, and these changes and improvements all fall in the claimed scope of the invention.Application claims protection domain is defined by appending claims and equivalent thereof.
Claims (6)
1. be used for the treatment of a Chinese medicine composition for vexed insomnia, it is characterized in that: the medicament be made up of the crude drug of following weight portion,
Fructus Gardeniae 8-10 part, Radix Paeoniae Alba 8-10 part, Bulbus Fritillariae Thunbergii 8-10 part, Radix Puerariae 8-10 part, Semen Ziziphi Spinosae 11-13 part, Semen Lablab Album 11-13 part, Fructus Schisandrae Chinensis 8-10 part.
2. a kind of Chinese medicine composition being used for the treatment of vexed insomnia according to claim 1, is characterized in that: the medicament be made up of the crude drug of following weight portion,
Fructus Gardeniae 9 parts, the Radix Paeoniae Alba 9 parts, Bulbus Fritillariae Thunbergii 9 parts, Radix Puerariae 9 parts, Semen Ziziphi Spinosae 12 parts, Semen Lablab Album 12 parts, Fructus Schisandrae Chinensis 9 parts.
3. a kind of Chinese medicine composition being used for the treatment of vexed insomnia according to claim 1, is characterized in that: described preparation is oral formulations.
4. a kind of Chinese medicine composition being used for the treatment of vexed insomnia according to claim 3, is characterized in that: described oral formulations is decoction.
5. prepare a method for Chinese medicine composition described in any one of claim 1 or 2, it is characterized in that: comprise the following steps,
1) each taste crude drug is taken by parts by weight described in prescription;
2) above-mentioned each taste material medicine is mixed being placed in marmite adds water did not have powder, soak after 30 minutes, with slow fire boiling, renew after boiling and decoct 30 minutes, decoct three times altogether, merges three decocting liquids filtrations, obtain decoction.
6. the purposes of Chinese medicine composition in the vexed insomnia drug for the treatment of according to any one of claim 1 or 2.
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Non-Patent Citations (2)
| Title |
|---|
| 陈自雅,等.顽固性失眠中医研究进展.《辽宁中医药大学学报》.2012,第14卷(第5期),第244-246页. * |
| 黄露,等.中医治疗失眠新进展.《中医药临床杂志》.2012,第24卷(第6期),第579-580页. * |
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Effective date of registration: 20180522 Address after: 511400 Guangdong Jinshi village, Jinshan Village, Shiji Town, Panyu District, Guangzhou, B22 Patentee after: Guangzhou Jindian Jingfang Pharmaceutical Co., Ltd. Address before: 236508 5 Xu Si administrative village, Guang Wu Town, Jieshou City, Fuyang, Anhui Patentee before: Xu Ruyang |