CN103599471A - Traditional Chinese medicine composition for young female depression - Google Patents
Traditional Chinese medicine composition for young female depression Download PDFInfo
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Abstract
A traditional Chinese medicine composition for young female depression relates to the technical field of Chinese herbal medicine. The traditional Chinese medicine is composed of the following bulk drugs by weight: 29-31 g of fushen, 11-13 g of fiveleaf akebia fruit, 14-16 g of radix bupleuri, 11-13 g of Radix Paeoniae Alba, 14-16 g of bighead atractylodes rhizome, 9-11 g of root bark of the peony tree, 14-16 g of turmeric, 14-16 g of angelica, 9-11 g of mint, 29-31 g of blighted wheat, 29-31 g of tuber fleeceflower stem, 14-16 g of albizia bark, 19-21 g of pseudostellaria root, 9-11 g of dryopteris crasirhitom nakai and 14-16 g of deerhorn glue. The traditional Chinese medicine provided by the invention is developed by combining the basis of syndrome differentiation of traditional Chinese medicine with many years of clinical practice. A plurality of medicines are combined to realize the efficacies of nourishing heart, tranquillizing, rectifying qi and resolving depression, and have the characteristics of exact curative effect, quick effectiveness, high cure rate and no toxic or side effect.
Description
Technical field
The present invention relates to field of Chinese herbal medicine technology, be specifically related to a kind of Chinese medicine composition for young women depression.
Background technology
Depression is a kind of common mental sickness, and main manifestations is depressed, and interest lowers, pessimism, retardation of thinking, lacks initiative, and self-accusation is from crime, and diet, sleep are poor, worrying oneself to suffer from various diseases, feel that whole body many places are uncomfortable, can there is suicidal thought and behavior in severe patient.Depression mainly be take depressive mood, retardation of thinking and bulesis and is gone down as main, and majority of cases also exists various somatizations.Comprising sleep disordered (difficulty falling asleep, shallow, the early awakening of sleeping, or others to think that he sleeps fine, but feel in person own a bit sleeping), weak or energy goes down, (70% patients with depression all can occur this situation in appetite decline, light showing as there is not appetite, and serious symptom shows as loses appetite), the non-specific somatization such as sexual hypofunction (amenorrhea can appear in women during depression), weight loss, constipation, whole body pain discomfort.
Depression is the highest disease of psychiatric department homicide rate.Depression rate is very high, almost in every 7 adults, just have 1 patients with depression, so it is called as the flu in psychiatry.Depression has become the second important diseases that causes serious burden in global disease to the mankind at present, the misery that patient and family members thereof are caused, and the loss that society is caused is that other diseases is incomparable.Some areas Epidemiological study data of carrying out according to the new classification of diseases of application and diagnostic system shows, it is close that China's depression prevalence is about the statistical result of 29%-35% left and right ，Yi Yu developed country.
Antidepressants are the medicines that class primary treatment is depressed, mood is depressed, pessimistic, passive, can make emotion rouse oneself after medication, strengthen ability of thinking and energy is taken a turn for the better.This class medicine has many kinds, since coming out the fifties, develop very soon, and particularly closely since the more than ten years, many novel antidepressants emerge in an endless stream.This class medicine not only has antidepressant curative effect, and anxious, obsessive state and phobia are also had to certain curative effect.According to the difference of chemical constitution, antidepressants are roughly divided three classes: oxidase inhibitor, tricyclic antidepressants and heterocyclic antidepressant.But above-mentioned Western medicine is all not aobvious to the uncomfortable symptom curative effect of various bodies.Main untoward reaction has: insomnia, dizziness, headache, postural hypotension, tendon hyperreflexia, tremble, unable, hyperhidrosis, xerostomia, drowsiness, the dysuria also having, sexual impotence etc.Also may there is skin allergy.Serious side effect is: hypertensive crisis and toxic hepatitis, so, should before taking medicine and after medication, regularly check and examine blood pressure and liver function.Have hepatitis history and cerebrovascular patient forbidding, old people is cautious use of.
The shortcoming of Western medicine is: to the uncomfortable symptom curative effect of various bodies is aobvious, do not make patient compliance poor; Side effect is many and more serious, makes patient be difficult to accept; In addition new drug price is all more expensive, makes patient be difficult to bear.
Chinese medicine is the rarity of China, and still, it is also very limited to the research of depression.The Chinese medicine of Cure of depression or Chinese patent medicine are also not bery ripe.The dispersing the stagnated live-QI to relieve the stagnation of QI capsule that the Chinese patent medicine of selling in the market only has Chengdu Kang Hong Pharmaceutical to produce according to the retrieval, mainly for the depression of liver energy stagnation type.During the antidepressants of announcing in country are applied for a patent, nearly Chinese medicine kind more than 90, but all in conceptual phase.Clinical depressive patient is often with anxiety symptom, and the achievement in research finding that the Chinese medicine of Cure of depression has angst resistance effect is simultaneously very few.Therefore, the Cure of depression of exploitation comparative maturity has good therapeutic effect, and the Chinese patent medicine that has again certain angst resistance effect is simultaneously clinical and demand market.
Summary of the invention
It is a kind of effective that technical problem to be solved by this invention is to provide, the safe and reliable Chinese medicine composition for young women depression.
Technical problem to be solved by this invention realizes by the following technical solutions:
For a Chinese medicine composition for young women depression, by the crude drug of following weight, formed,
Poria cum Radix Pini 29-31 gram, Fructus Akebiae 11-13 gram, Radix Bupleuri 14-16 gram, Radix Paeoniae Alba 11-13 gram gram, Rhizoma Atractylodis Macrocephalae 14-16 gram, Cortex Moutan 9-11 gram, Radix Curcumae 14-16 gram, Radix Angelicae Sinensis 14-16 gram, Herba Menthae 9-11 gram, Fructus Tritici Levis 29-31 gram, Caulis Polygoni Multiflori 29-31 gram, Cortex Albiziae 14-16 gram, Radix Pseudostellariae 19-21 gram, Rhizoma Osmundae 9-11 gram, Colla cornus cervi 14-16 gram.
Preferred weight part of each crude drug is:
30 grams of Poria cum Radix Pinis, 12 grams of Fructus Akebiaes, 15 grams of Radix Bupleuri, 12 grams of the Radix Paeoniae Albas, 15 grams of the Rhizoma Atractylodis Macrocephalaes, 10 grams of Cortex Moutans, 15 grams of Radix Curcumaes, 15 grams of Radix Angelicae Sinensis, 10 grams of Herba Menthaes, 30 grams of Fructus Tritici Levis, 30 grams of Caulis Polygoni Multiflori, 15 grams of Cortex Albiziaes, 20 grams of Radix Pseudostellariaes, 10 grams of Rhizoma Osmundae, 15 grams of Colla cornus cervis.
The present invention's crude drug used can be bought and obtain from common Chinese shop, and its specification meets national Chinese crude drug standard.
Another object of the present invention is to provide a kind of method of preparing the present composition, comprises the steps,
1) by the described weight of prescription, take each taste crude drug;
2) by above-mentioned each taste crude drug pulverization, incapsulate.
1, pharmacology analysis:
Poria cum Radix Pini: cure mainly the palpitation with fear of having a guilty conscience, forgetful, insomnia, infantile convulsion, dysuria.
Fructus Akebiae: liver-smoothing, qi-regulating, promoting blood circulation and stopping pain, relieving restlessness diuresis.
Radix Bupleuri: reconciling superficies and interior, soothing the liver, yang invigorating.Control alternate attack of chill and fever, fullness in the chest and hypochondriac pain, bitter taste is deaf, headache and dizziness, malaria, diarrhea proctoptosis, menoxenia, uterine prolapse.
The Radix Paeoniae Alba: nourishing blood to suppress the hyperactive liver, slow middle pain relieving, yin fluid astringing is received antiperspirant.Control the breast abdomen pain over the hypochondriac region, dysentery stomachache, spontaneous sweating, fever due to yin deficiency, menoxenia, metrorrhagia, leukorrhagia.
The Rhizoma Atractylodis Macrocephalae: spleen reinforcing, stomach reinforcing, dampness, and in, antiabortive.Control deficient QI of the spleen and stomach, anorexia, asthenia weak breath, deficiency-distension, has loose bowels, phlegm retention, edema, jaundice, arthralgia chiefly caused by damp pathogen, dysuria, dizziness, spontaneous perspiration, nausea is uneasy.
Cortex Moutan: clearing away heat and cooling blood, and blood repercussive.Control the pathogenic heat attacking blood system in febrile diseases, send out speckle, infantile convulsion, tells, is defeated in battle, has blood in stool, hectic fever due to YIN-deficiency consumptive fever, amenorrhea ， mass in the abdomen, carbuncle and ulcer, traumatic injury.
Radix Curcumae: promoting QI circulation for relieving depression, removing heat from blood removing blood stasis with potent drugs.Control all pains of breast abdomen side of body rib, lose the heart demented, calentura coma, spits blood, epistaxis, hematuria, stranguria with blood, women's vicarious menstruation, jaundice.
Radix Angelicae Sinensis: benefiting blood and regulating blood circulation, menstruction regulating and pain relieving, moisturizes laxation.Control menoxenia, amenorrhea stomachache ， mass in the abdomen knot is poly-, metrorrhagia; Headache due to deficiency of blood, dizzy, flaccidity syndrome and arthralgia syndrome; Dryness of the intestine dyschezia is heavy after bloody dysentery; Carbuncle skin ulcer is stolen, injury from falling down.
Herba Menthae: dispelling wind-heat, refresh oneself, rash.For anemopyretic cold, pathogenic wind-warm from the beginning of, headache, conjunctival congestion, sore throat, aphtha, rubella, measles, breast side of body feeling of distension and oppression.
Fructus Tritici Levis: the modern Practical Chinese medicinal > of < < >: reinforcing the heart, only tired, heat extraction, arresting sweating, diuresis.
Cortex Albiziae: cure mainly irritability, melancholy insomnia, lung abscess, carbuncle, scrofula, injured bone.
Caulis Polygoni Multiflori: cure mainly insomnia, impairment caused by overstrain, hyperhidrosis, blood deficiency general pain, carbuncle, scrofula, wind skin ulcer scabies.
Radix Pseudostellariae: tonifying the lung, strong board.Control cough due to deficiency of the lung, insufficiency of the spleen lack of appetite, cardiopalmus spontaneous perspiration, spirit is tired.
Rhizoma Osmundae: heat-clearing and toxic substances removing, cooling blood for hemostasis.Expelling wind and activating blood circulation, invigorating the liver and kidney.
Colla cornus cervi: enrich blood, benefit essence.Control deficiency of kidney-QI, asthenia weakness and emaciation, lumbago, carbuncle of yin nature, impotence in male, spermatorrhea, uterus cold caused by deficiency, metrorrhagia, leukorrhagia.
2, usage and consumption:
The dosage of medicine of the present invention depends on concrete dosage form, and the factor such as age of patient, body weight, health status.
Instruction: each 6, every day 3 times, the morning, noon and afternoon take, be 1 month a course for the treatment of.
3, the present composition has carried out a large amount of clinical trials of a large amount of animal acute toxicity tests, long-term toxicity test for animals and treatment disease, and the use link that this medicine is dropped into treatment disease provides science and objective foundation.
Its test method and result of the test are as follows respectively:
1) capsule of being prepared by the present invention carries out animal acute toxicity test:
Medicine: the present invention's crude drug used is bought and obtained from common Chinese shop, and its specification meets national Chinese crude drug standard.
Experimental animal: white mice, body weight is in 50g left and right, and male and female are selected at random, by market, are bought.
Method and result: get 30 of white mice, hungry about 20 hours, by filling with several times every every day, feed 50g, feed one week continuously, to observe 10 days, mice is movable normal, and non-toxic reaction, without dead.Show that oral liquid is without acute toxicity, clinical medicine dose safety.
2) capsule of being prepared by the present invention carries out long-term toxicity test for animals:
Experimental animal: rat, body weight is at 120-130g, and male and female are selected at random, by market, are bought.
Method and result: get 20 of rat, be divided into 2 groups, every group 10, wherein the 1st group as administration group, by filling with several times every every day, feed 40-50g, the 2nd group of normal feeding as a control group, once a day, continuous irrigation is fed 90 days, survey body weight, 24 hours sacrificed by decapitation after last administration, survey blood, routine urinalysis, liver function, renal function, core, the internal organs such as kidney, the variation of tissues observed form, observe the effect of dosage, observe diet, movable variation, experimental results show that administration group and matched group are relatively without significant change, equal non-toxic reaction, a kind of safe drugs.
4, diagnostic criteria
1) tcm diagnosis: life is hollow or desperate, sad melancholy is kind cries, and depressed, interest goes down, palpitation and insomnia, susceptible to lose temper due to restlessness, inadequate sexual desire, self-value declines, until there are the symptoms such as suicidal tendency.
2) in order to verify clinical efficacy, this prescription is tried out in Jieshou City, Anhui Province institute of traditional Chinese medicine, chooses at random wherein 50 routine female patients, and the age is in 16-35 year.
3) Therapeutic Method: take capsule of the present invention, divide for each person every day and take for 3 times, one time 6, take continuously 1 month.
4) efficacy determination:
According to 17 versions of HAMD curative effect standards of grading and < < traditional Chinese medical science disease Standardization of diagnosis and curative effect > > (State Administration of Traditional Chinese Medicine. the traditional Chinese medical science disease Standardization of diagnosis and curative effect M}. Nanjing: publishing house of Nanjing University, 1994.).
Effective: integration is down to 7 minutes, transference cure or obviously improvement, emotion is normal.Effective: integration is down to 8-10 and is divided, partial symptoms is improved, and emotion is basicly stable.Invalid: integration is more than 18 minutes, and symptom emotion is without improvement.
Concrete therapeutic outcome is referring to table 1;
Table 1
| Number of cases | Effective | Effectively | Invalid | Effective percentage (%) |
| 50 | 25 | 23 | 2 | 96 |
5, points for attention:
1. diet should be light, gives up alcohol and pungent, raw and cold, greasy food.
2. child, women breast-feeding their children, elderly and infirm should take under doctor instructs.
3. driver, work high above the ground person are cautious use of.
4. strictly by usage and dosage, take.
5. pair this medicine and ethanol allergy sufferers are forbidden, and allergic constitution person be cautious use of.
6. when this property of drug changes, ban use of.
7. please this medicine is placed on to the place that child can not contact.
8. as use other medicines, using please Ref Dr or pharmacist before this medicine.
The invention has the beneficial effects as follows: the present invention develops in conjunction with clinical practice for many years on the basis of Traditional Chinese Medicine determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs.All medicines amount to mutually there is tranquilizing by nourishing the heart, the effect of the resolving depression of regulating the flow of vital energy, the feature such as treatment young women depression has determined curative effect, instant effect, cure rate is high and have no side effect.
The specific embodiment
For technological means, creation characteristic that the present invention is realized, reach object and effect is easy to understand, below in conjunction with specific embodiment, further set forth the present invention.
Embodiment 1
By following weight, take each crude drug: 30 grams of Poria cum Radix Pinis, 12 grams of Fructus Akebiaes, 15 grams of Radix Bupleuri, 12 grams of the Radix Paeoniae Albas, 15 grams of the Rhizoma Atractylodis Macrocephalaes, 10 grams of Cortex Moutans, 15 grams of Radix Curcumaes, 15 grams of Radix Angelicae Sinensis, 10 grams of Herba Menthaes, 30 grams of Fructus Tritici Levis, 30 grams of Caulis Polygoni Multiflori, 15 grams of Cortex Albiziaes, 20 grams of Radix Pseudostellariaes, 10 grams of Rhizoma Osmundae, 15 grams of Colla cornus cervis.By above-mentioned each taste crude drug pulverization, be prepared into according to a conventional method capsule.
Embodiment 2
By following weight, take each crude drug: 31 grams of Poria cum Radix Pinis, 13 grams of Fructus Akebiaes, 16 grams of Radix Bupleuri, 13 grams of the Radix Paeoniae Albas, 16 grams of the Rhizoma Atractylodis Macrocephalaes, 11 grams of Cortex Moutans, 16 grams of Radix Curcumaes, 16 grams of Radix Angelicae Sinensis, 11 grams of Herba Menthaes, 31 grams of Fructus Tritici Levis, 31 grams of Caulis Polygoni Multiflori, 16 grams of Cortex Albiziaes, 21 grams of Radix Pseudostellariaes, 11 grams of Rhizoma Osmundae, 16 grams of Colla cornus cervis.By above-mentioned each taste crude drug pulverization, be prepared into according to a conventional method capsule.
Embodiment 3
By following weight, take each crude drug: 29 grams of Poria cum Radix Pinis, 11 grams of Fructus Akebiaes, 14 grams of Radix Bupleuri, 11 grams of the Radix Paeoniae Albas, 14 grams of the Rhizoma Atractylodis Macrocephalaes, 9 grams of Cortex Moutans, 14 grams of Radix Curcumaes, 14 grams of Radix Angelicae Sinensis, 9 grams of Herba Menthaes, 29 grams of Fructus Tritici Levis, 29 grams of Caulis Polygoni Multiflori, 14 grams of Cortex Albiziaes, 19 grams of Radix Pseudostellariaes, 9 grams of Rhizoma Osmundae, 14 grams of Colla cornus cervis.By above-mentioned each taste crude drug pulverization, be prepared into according to a conventional method capsule.
Model case:
Case 1
So-and-so people from Xuancheng City of ，Nv ，19Sui， Anhui Province of stone.After college entrance examination finishes, spirit depressing, malaise, the kind worry of thinking much, sad melancholy are wanted to cry always, examine as depression.Multi-treatment poor effect, go to a doctor in here in August, 2011, oral Drug therapy of the present invention after 4 courses for the treatment of symptom all disappear, it is normal that viability is all recovered.Follow up a case by regular visits to not recurrence in a year.
Case 2
Bai, female, 22 years old, people from Tongling Anhui.Suffer from depression more than 1 year, long-term absentminded, multi-treatment is invalid, over the past half year self-induction aggravation, malaise, suspicious susceptible to fright, stretch oneself and yawn constantly.Go to a doctor in here in August, 2012, and oral Drug therapy of the present invention is after 4 courses for the treatment of, and symptom disappears substantially, after continue again to have taken 4 courses for the treatment of and consolidated, cure.Follow up a case by regular visits to not recurrence in a year.
Case 3
Congratulate certain Fuyang City people of ，Nv ，31Sui， Anhui Province.Absentminded, close in the heart, nearly 1 year of cardiopalmus, insomnia, susceptible to lose temper due to restlessness.Go to a doctor in here in January, 2012, examines as depression, give Drug therapy of the present invention after 4 courses for the treatment of symptom all disappear.Follow up a case by regular visits to not recurrence in a year.
More than show and described ultimate principle of the present invention and principal character and advantage of the present invention.The technical staff of the industry should understand; the present invention is not restricted to the described embodiments; that in above-described embodiment and description, describes just illustrates principle of the present invention; without departing from the spirit and scope of the present invention; the present invention also has various changes and modifications, and these changes and improvements all fall in the claimed scope of the invention.The claimed scope of the present invention is defined by appending claims and equivalent thereof.
Claims (2)
1. for a Chinese medicine composition for young women depression, it is characterized in that: the crude drug by following weight forms,
Poria cum Radix Pini 29-31 gram, Fructus Akebiae 11-13 gram, Radix Bupleuri 14-16 gram, Radix Paeoniae Alba 11-13 gram gram, Rhizoma Atractylodis Macrocephalae 14-16 gram, Cortex Moutan 9-11 gram, Radix Curcumae 14-16 gram, Radix Angelicae Sinensis 14-16 gram, Herba Menthae 9-11 gram, Fructus Tritici Levis 29-31 gram, Caulis Polygoni Multiflori 29-31 gram, Cortex Albiziae 14-16 gram, Radix Pseudostellariae 19-21 gram, Rhizoma Osmundae 9-11 gram, Colla cornus cervi 14-16 gram.
2. a kind of Chinese medicine composition for young women depression according to claim 1, is characterized in that: the crude drug by following weight forms,
30 grams of Poria cum Radix Pinis, 12 grams of Fructus Akebiaes, 15 grams of Radix Bupleuri, 12 grams of the Radix Paeoniae Albas, 15 grams of the Rhizoma Atractylodis Macrocephalaes, 10 grams of Cortex Moutans, 15 grams of Radix Curcumaes, 15 grams of Radix Angelicae Sinensis, 10 grams of Herba Menthaes, 30 grams of Fructus Tritici Levis, 30 grams of Caulis Polygoni Multiflori, 15 grams of Cortex Albiziaes, 20 grams of Radix Pseudostellariaes, 10 grams of Rhizoma Osmundae, 15 grams of Colla cornus cervis.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103861005A (en) * | 2014-03-26 | 2014-06-18 | 胡向仟 | Traditional Chinese medicine composition with anti-anxiety effect |
| CN104906431A (en) * | 2015-06-30 | 2015-09-16 | 青岛海之星生物科技有限公司 | Traditional Chinese medicine decoction for treating depression and preparation method of traditional Chinese medicine decoction |
| CN105126024A (en) * | 2015-09-09 | 2015-12-09 | 孔令刚 | Traditional Chinese medicine for depression of young women |
| CN108210607A (en) * | 2018-04-04 | 2018-06-29 | 胡碧原 | A kind of Chinese medicine for treating dyspareunia |
-
2013
- 2013-10-21 CN CN201310496332.9A patent/CN103599471A/en active Pending
Non-Patent Citations (1)
| Title |
|---|
| 黄爱珍等: "疏肝解郁方治疗女青年抑郁症临床观察", 《上海中医药大学学报》 * |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103861005A (en) * | 2014-03-26 | 2014-06-18 | 胡向仟 | Traditional Chinese medicine composition with anti-anxiety effect |
| CN103861005B (en) * | 2014-03-26 | 2016-03-30 | 胡向仟 | A kind of Chinese medicine composition with angst resistance effect |
| CN104906431A (en) * | 2015-06-30 | 2015-09-16 | 青岛海之星生物科技有限公司 | Traditional Chinese medicine decoction for treating depression and preparation method of traditional Chinese medicine decoction |
| CN105126024A (en) * | 2015-09-09 | 2015-12-09 | 孔令刚 | Traditional Chinese medicine for depression of young women |
| CN108210607A (en) * | 2018-04-04 | 2018-06-29 | 胡碧原 | A kind of Chinese medicine for treating dyspareunia |
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Application publication date: 20140226 |