CN103861005B - A kind of Chinese medicine composition with angst resistance effect - Google Patents
A kind of Chinese medicine composition with angst resistance effect Download PDFInfo
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Abstract
The invention discloses a kind of Chinese medicine composition with angst resistance effect, it is made up of the crude drug of following weight portion: Cortex Moutan 10 ~ 18; The Radix Paeoniae Alba 10 ~ 18; Olibanum 6 ~ 12; Fructus Alpiniae Oxyphyllae 7 ~ 10; Flos Inulae 7 ~ 10.This Chinese medicine composition cures mainly the depressed stagnation of phlegm of anxiety disorder patient, malaise.Both can be used as drug combination antianxity, also can be used for maintenance phase, or prevention of recurrence medication.And for being secondary to the anxiety of physical disease.Be applicable to symptom changeable, various types of anxiety disorder patient in combination medication of course of disease delay, or maintenance phase medication, or prevention of recurrence.Be particularly suitable for the use of the physical disease such as anxiety and tumor, apoplexy, coronary heart disease mood regulation sick altogether.Its clinical application has a extensive future.
Description
Technical field
The invention belongs to medical art, be specifically related to a kind of Chinese medicine composition with angst resistance effect.
Background technology
Anxiety is a kind of common emotion, and when its order of severity and objective fact are not inconsistent, or the persistent period is excessively of a specified duration, then become anxiety disorder (anxietydisororder) also known as anxiety neurosis.Comprise extensive anxiety, panic attack, Social Anxiety and stress disorders etc.Of common occurrence in daily life, these patient too's vigilance, nervous, timidity is feared, responsive, or sensation of asphyxia, and chest contracting squeezes sense, myalgia, insomnia, frequent micturition etc.Entertain imaginary or groundless fears all day, likely all live unhappy a lifetime.
Chinese scholars is reported: WHO has carried out the world mental health investigation (WMHS) and cross-culture study to 28 countries comprising China, find from western countries' 14 epidemiological studies such as the U.S., New Zealand, Canada, Norway, Germany, Australia completing the research, in crowd, anxiety disorder lifetime prevalence is 13.6% ~ 18.6%, and annual loading is 5.6% ~ 19.3%.In the Beijing-Shanghai sample of WHO/WMHS, to census of population between 5210 18-70 one full year of life, Shen fishing Estate, Zhang Mingyuan etc. find that anxiety disorder annual loading is 2.7%.Comparatively early, 80 ~ 90% fell ill anxiety disorder age of onset before 35 years old, within 10-25 years old, were the onset peak age.Anxiety disorder has the chronic course of disease, and relapse rate is high, and sick rate is high altogether, the features such as the obvious defect of social function.(drawing certainly: Wu Wenyuan edits: " guideline of prevention and treatment of anxiety disorder ", artificial satellite publishing house, the first edition in 2010).
Anxiety disorder, because having chronic or chronic paroxysmal process, therefore needs the full course of disease to prevent and treat, and in the different phase of the course of disease, needs different measures.This causes the extreme difficulties of clinical treatment.At present, Western medicine antianxiety drugs has following three classes:
1) Benzodiazepines: as alprazolam, diazepam, estazolam, clonazepam, chlordiazepoxide etc.
2) the grand class of atropic piperazine: as buspirone, tandospirone.
3) other antidepressants, psychosis, as paroxetine, fluoxetine, escitalopram, deanxit etc. are also used as anxiety.
Although simple western medicine treatment has rapid-action advantage to some patients, not lasting.And the maintenance phase of anxious patients is very long for medicine time, especially prevention of recurrence often need be taken medicine 1-2 years, even longer.So take antianxiety drugs for a long time, easily cause drug dependence, patient extremely worries, and even someone looks as " drugs ".This worry increases the weight of anxiety on the contrary, or yields treatment.The difficulty of withdrawal reaction especially in the difficulty that faces of doctor.Therefore, seeking plant amedica antianxity or Chinese medicine preparation has been Chinese scholars common recognition.At present, domestic treatment by Chinese herbs anxiety disorder is still controlled with clinical syndrome differentiation opinion, and decoct is main.There is dialectical disunity, the situation that medication is numerous and diverse.Commercially available Chinese medicine special preparation is few, and new varieties only have " nine taste relieving palpitation granules " a kind of (its component is: Radix Ginseng, Semen Ziziphi Spinosae, Fructus Schisandrae Chinensis, Poria, Radix Polygalae, Rhizoma Corydalis, Radix Asparagi, Radix Rehmanniae Preparata, Cortex Cinnamomi), and its effect is tranquilizing by nourishing the heart, and sphere of action is limited.The Chinese patent medicine of other dispersing the stagnated live-QI to relieve the stagnation of QI, as ease pill, Chaihushugan Pill, Herba Hyperici Monogyni (panacea writing brush grass), capsule for reliving liver and reliving upset, Radix Morindae Officinalis oligosaccharide capsule etc. are also for anxiety.
Not single because of single fruit based on anxiety disorder, also caused by certain single specific neurotransmitter levels change non-.Therefore, the medicine of any single target, is difficult to play the drug effect regulating anxiety.
Summary of the invention
The present invention is intended to overcome the deficiencies in the prior art, provides a kind of Chinese medicine composition with angst resistance effect.
For achieving the above object, technical scheme provided by the invention is:
The described Chinese medicine composition with angst resistance effect is made up of the crude drug of following weight portion:
Preferably, described Chinese medicine composition is made up of the crude drug of following weight portion:
Preferably, described Chinese medicine composition is made up of the crude drug of following weight portion:
Preferably, described Chinese medicine composition is made up of the crude drug of following weight portion:
The dosage form of Chinese medicine composition of the present invention is Chinese herbs decoction.
Below in conjunction with tcm prescription principle, the invention will be further described:
This compositions principle is explained as follows:
The clinical manifestation of anxiety disorder patient can divide spirituality anxiety (expection property anxiety, emotion is uneasy) and somatic anxiety (uneasiness of moving), the former with anxiety, anxiety, worry, fear, in terror, for core, the latter is with sympathetic hyperfunction, be on tenterhooks, sensation of asphyxia, myalgia, the somatizations such as frequent micturition are core.The palpitation with fear of this and the traditional Chinese medical science, alarmed and panicky, be insomnia, the emotional disorder such as Bulbus Lilii syndrome, hysteria, globus hystericus has many similar." make us fearing so dynamic and uneasy, looking lost, fears will catch as people " described by ancient books and records.The relevant etiology and pathogenesis traditional Chinese medical science is discussed very auspicious." Plain Questions lift pain opinion " carries: " think, the heart is deposited to some extent, and god returns to some extent, and healthy energy is stayed and not all right, therefore depressed." Zhang Jingyue says: " and husband's all diseases being caused by disorder of QI, just with gas for use, penetrate everywhere, one has uncomfortable, then not sick without institute, therefore it outer then has invading of six gas, interior, have nine gas disorderly, and disease is empty for real, for heat is cold, very it is abnormal, cannot be described, for asking it, then a positive gas word is enough to use up it, lid gas has uncomfortable part, and namely this whereabouts sick also ".Visible, gas is the treasured of the person, circumfluence the whole body, ordinary person's vital organs of the human body, muscles and bones skin and flesh blood vessels, in a moment continuously.Note in worried things if the mind is stayed, gas also condenses not all right thereupon staying note, it can thus be appreciated that the mechanism of qi change of " think of " is exactly depressed.And seven emotions overaction of the five emotions, be then the pole that gas is crossed, gas crosses then heat-dissipating.ZHU Dan-xi meaning " excessive QI becoming fire ", again " expectorant be thing, fall with gas lift, nowhere less than ".Clear Tang ancestor sea is said: " also, also, none disease is not in relation to gas to the instituteization of water and gas, therefore none disease is not in relation to expectorant for expectorant and water ".As can be seen here, seven emotions overaction of the five emotions, internal injury in melancholy anger, then gas superinverse, QI rising in reverse order then the six channels is obstructed, fluid transformed into phlegm by fire, cause normal spleen to rise stomach to fall, the liver lung that relaxes falls, the mechanism of qi multilateds such as heart kidney traffic, but, the source of gas, send out in kidney, for lung, unite in spleen, row, in inner, protects in table.Qi activity disturbance is not the unbalance of a dirty internal organs.In conjunction with the clinical findings of anxiety disorder, inventor thinks that pathogenesis relates to gas, blood, expectorant.Key is " gas with too ", disorder of movement of QI, and causes depressed stagnation of phlegm, but not refers to the number of gas, thus treatment then benefit can not, what rush down is unhelpful.Therefore propose: the Therapeutic Principle of " depressedly should lead to, expectorant knot should fall ".
Cortex Moutan in the present invention is as monarch drug, and Cortex Moutan has another name called Radix Ardisiae Crispae, Cortex Moutan, wooden Radix Paeoniae etc.For the root of Paeoniaceae plant Cortex Moutan.Main containing paeonol, paeonoside, peoniflorin etc.The property of medicine is worked hard, and is slightly cold.Enter liver, the heart, kidney channel.Merit arrogates to oneself cool the blood dissipate blood stasis, and promoting the circulation of QI stimulates the menstrual flow, removing the relative excess heat, flat fire mutually.Paeonia suffruticosa gathers the gas in the world, is the king that group spends.Its anger is hidden in root, raw Seedling on root, therefore claims male (male, staminiferous plant also), is used as medicine for root bark." Sheng Nong's herbal classic " carries: " abnormal smells from the patient is pungent cold nontoxic.Main cold and heat, infantile convulsion pathogen ... settling five organs " etc.Clear Zou Shu meaning: " acrid in the mouth can lead to, and gas is cold can fall, and is think obstruction-removing prescription.Extremely, extremely here gas must, and blood is not declared, and gas is also stopped up in the institute of all blood ... blood a surname gas is capable, the first-class merit of this Cortex Moutan." Ni Zhumo says: " Cortex Moutan, the disease of all vim and vigour all, system can control it." unit's clean quoth: " training the mind will is not enough ".Clear Chen Xiuyuan is said: " Cortex Moutan gas is trembled with fear, and reports aqueous vapor and enters kidney, obtain golden taste and enter lung, the lung covering and protecting the other ZANG-organs, and lung is pacified and the five internal organs are all pacified ".YE Tian shi is said: " Cortex Moutan is pungent cold, lung benefiting suppressing the hyperactive liver, and irritability does not rise and lung qi falls, and all diseases are put down." by the inspiration of above-mentioned classics, know from experience in conjunction with clinical application, in we, get Cortex Moutan property and flavor of peppery and cold, a surname's venting QI-blood, flat fire mutually of holding concurrently, beneficial mind.Fiery in order to control the cloudy second of the three ten-day periods of the hot season, heat clearing away and restlessness relieving, removing heat from blood promoting the circulation of QI, can tie with general solution.For anxiety disorder patient seven emotions overaction of the five emotions in side, " gas with too " and cause depressed basic pathogenesis and establish, make gas not heat-transformation, blood does not hinder gas, and blood a surname gas is capable and play the merit of " obstruction-removing prescription ".Therefore be monarch drug.
Cortex Moutan modern pharmacological research is as follows:
1. Cortex Moutan water decoction has antiinflammatory, antiallergic, blood pressure lowering, the effect resisted myocardial ischemia.
2. Cortex Moutan total glycosides Wheat Protein.
3. Cortex Moutan phenol has antipyretic, antalgic and sedative, antitumor, study of anti-atherogenic effect.
The application of Cortex Moutan in eight first ancient prescriptions is in table 1
Table 1
Yet there are no the research report of single Cortex Moutan anxiety obstacle.
The Radix Paeoniae Alba in the present invention and Olibanum are ministerial drug.
The Radix Paeoniae Alba has another name called Radix Paeoniae Alba, Radix Paeoniae.
For the root of Paeoniaceae plant peony and Peony.Main containing peoniflorin, oxypaeoniflorin, Radix Paeoniae aglycon ketone, peony lactone etc.The acid of property of medicine bitter in the mouth, is slightly cold.Enter liver, spleen channel.Merit arrogate to oneself nourish blood and seek, relieving spasm to stop pain, adjust the gas in blood.Radix Paeoniae October germinates, and March blooms, and broken YIN-cold is coagulated freeze and goes out, and takes advantage of yang-energy flourishing and flourish, is the phase in spending.The color that Radix Paeoniae is bright, the gas of strong fragrance, suitable with the gas phase in blood.Can be broken cloudy solidifying, Bu Yang and, can complementary energy rush down, special promoting the circulation of blood sea, woman's regulating menstruation is multiplex.Clear yellow palace is embroidered and is said: " enter Liver Channel blood system astringing QI.Edge QI belonging to YANG, blood pertaining to YIN, blood is contained in gas, and then blood clotting is not all right, and arrogant in blood, then blood is dry and beneficial withered, the Sheng person of the blood, and Bi Laixin falls apart for it, the Sheng person of the gas, and acid must be relied to receive for it, therefore the Radix Paeoniae Alba is number for holding back the liquid of liver, receives the gas of liver, and makes the not absurd row of gas also." in side, Radix Paeoniae Alba enters blood astringing QI, principal drug assistance Cortex Moutan a surname venting QI-blood, analgesia, therefore be ministerial drug.
Olibanum has another name called nipple perfume (or spice), and collapse perfume (or spice), and pool, sky is fragrant.
For the resin that the skin zone of olive subject plant Boswellia carterii oozes out.Main resinous, gummy, volatile oil, composition has free α, β-boswellic acid, olibanoresene, and piperitone, pinocamphone etc.The property of medicine is worked hard tepor, enters the heart, liver, spleen channel.Merit arrogates to oneself blood-activating and qi-promoting, inducing menstruation to relieve menalgia, and reinforcing the heart is allayed excitement.The pungent perfume (or spice) of this product, enters heart circulation of qi promoting, can rise and can fall, fixed all warps pain.Cloud is embroidered in yellow palace: " heart scurried into by Olibanum perfume (or spice), and blood can be made to declare logical and muscle from stretching, and reactivation enters kidney temperature compensation, makes gas and blood logical alive mutually, and do not make blood hinder in order to do gas, blood is not also hindered by gas, therefore cloud function hemopoietic, study carefully the product ear of all promoting flow of QI and blood." (" book on Chinese herbal medicine is looked for the truth ") Southern Song Dynasty Chen Yan cloud: " Olibanum controls mental derangement, the sliding nocturnal emission person of essence, and lid gets that it is soft sticky, can help his medicine, to restrain mind also." (" Baoqing book on Chinese herbal medicine is compromise "), in we, conjunction monarch drug Cortex Moutan enters blood gas, help again ministerial drug Radix Paeoniae Alba emergency pain, favourable mitigation anxiety disorder patient's malaise and all diseases of myalgia, therefore be ministerial drug.
The formula that Chinese medicine preparation antianxity has no the Radix Paeoniae Alba, Olibanum is all ministerial drug commercially available at present.
Fructus Alpiniae Oxyphyllae in the present invention and Flos Inulae are adjuvant drug.
Fructus Alpiniae Oxyphyllae has another name called Fructus Alpiniae Oxyphyllae sub-， Zhai Ding.For the mature fruit of zingiberaceous plant Fructus Alpiniae Oxyphyllae.Main containing cyperone, cineole, zingiberene, zingiberol, aminoacid etc.Medicine property and flavor of peppery and warm, enters spleen, kidney channel.Merit is arrogated to oneself warming spleen and stopping diarrha, and it is inverse to hold back spleen kidney qi, improving inspiration by invigorating kidney-QI Gui Yuan.The pungent temperature of this product, the gas of YIN-cold of faling apart, help spleen and rise stomach and fall, make QI movement being in harmonious way and emesis rushes down, disappear stomachache.Cloud is embroidered in yellow palace: " Fructus Alpiniae Oxyphyllae, abnormal smells from the patient is hot, the special dry spleen stomach warming of merit, and holds back taste QI rising in reverse order, Zang Na Gui Yuan, and the agent of life is mended in number reinforcing the heart again." " Kaibao Bencao " cloud: " An Sanjiao, adjusts all gas for benefiting vital QI for tranquillizing, tonifying for the deficiency." Liu Yuansu says: " exploitation pent-up makes gas declare logical ", in we, receive with this take the photograph, warming the spleen, secret essence, make spleen rise stomach and fall, and improving inspiration by invigorating kidney-QI Gui Yuan, prevent taste impaired, all gas nursed one's health by collaborative ministerial drug.Therefore be adjuvant drug.
Flos Inulae has another name called volt flower, FLOSINULAE.For the head inflorescence of feverfew Flos Inulae.Main containing flavonoid glycoside, inusterol B, C, inulin etc.The property of medicine is bitter, pungent, salty, tepor, nontoxic.Enter lung, liver, stomach warp.Merit arrogates to oneself sending down the abnormal ascending QI expectorant, softening the hard mass diuretic, promoting blood circulation.This product temperature can be passed through, and salty energy softening the hard mass, control QI rising in reverse order, palpitation with fear is very tested.Li Shizhen (1518-1593 A.D.) is said: " all diseases of controlling, its merit is only expert at water, the therapeutic method to keep the adverse QI flowing downwards, promoting blood circulation you." clear Zou Shu writes " herbal classic dredges card " cloud: " and two side of body persons, the road of negative and positive, lifting want pivot, water is not returned soil and ties stagnant air flue, then for shying for throbbing with fear, (Flos Inulae) main stagnation of QI and fullness in the hypochondrium, palpitate with fear, i.e. the therapeutic method to keep the adverse QI flowing downwards, the merit dewatered is also." get the power of its special main lower and tonneau in we, play the effect of lifting hinge, pleasant machine adjusted by collaborative ministerial drug, favourable diuresis and phlem dispersing, therefore is adjuvant drug.
Inventor, by the inspiration of ancient Chinese medicine mechanism of qi theory, in conjunction with more than 40 years clinical practice experience, thinks the pathogenesis mainly seven emotions overaction of the five emotions that anxiety disorder relates to.Key is " gas with too " and cause depressed.ZHU Dan-xi is called: " excessive QI becoming fire ", and fire can fluid transformed into phlegm by fire, and causes gas, blood, expectorant for suffering from, stagnation of Qi and phelgm, and delay is difficult.The pathological changes of this non-dirty internal organs.Therefore, the Therapeutic Principle of " depressedly should lead to, expectorant knot should fall " is proposed.Medication must first removing heat from blood a surname be led to, and make gas not heat-transformation, blood does not hinder gas, just can reach with the object of general solution knot.Newly cognitive according to above-mentioned pathogenesis, it is logical that Chinese medicine composition of the present invention selects to have removing heat from blood a surname, and the Cortex Moutan ruling vim and vigour is monarch drug, is intended to utilize its acrid in the mouth can lead to, and gas is trembled with fear and can be fallen, and the liver lung that relaxes is fallen, and mutually fiery Gui Yuan, gives full play to the merit of " obstruction-removing prescription ".Minister with blood system astringing QI, the Radix Paeoniae Alba of relieving spasm to stop pain; Enter heart circulation of qi promoting, the Olibanum of convergence mind, the monarch and his subjects three medicine with entering blood system, from removing heat from blood, nourish blood, circulation of qi promoting, different angles of invigorating blood circulation, the capable power of synthesis blood a surname's gas, helps with the kidney warming improving inspiration by invigorating kidney-QI, the Fructus Alpiniae Oxyphyllae of allaying excitement; Sending down the abnormal ascending QI expectorant, the Flos Inulae of promoting blood circulation, assists monarch-minister drug to adjust pleasant machine from falling, receiving two aspects, stabilizes " too ", gathers altogether with the object of general solution knot.Present composition flavour of a drug are concise, and medical material used is pharmacopeia and records kind, wide material sources, and not containing toxicity medical material.Every day, crude drug amount was moderate, was applicable to making tablet or capsule, favourable exploitation and large-scale production.Be applicable to each hypotype of anxiety disorder, and the anxiety state of physical disease secondary.Popularizing application prospect is wide.
In short, compared with prior art, beneficial effect of the present invention is:
1, the present invention is according to the new cognition of anxiety disorder pathogenesis, proposes the Therapeutic Principle of " depressed should lead to, expectorant knot should fall ".Give full play to the compound drug effect advantage that regulating QI machine is apt to by Chinese medicine.
2, prescription theory is according to sufficient, and flavour of a drug are concise, and crude drug source is extensive, and avirulence medical material, does not relate to the problem such as environmental protection and animal and plant protection yet.
3, this compositions crude drug every day amount moderate (40 ~ 68g), is applicable to making tablet or capsule and large-scale production.Cost is low, is conducive to applying.
4, this compositions is applied widely, both can be used as the drug combination of each hypotype of anxiety disorder, also can be used for maintenance phase or prevention of recurrence.Or be total to sick treatment for anxiety and physical disease.
In a word, the present invention is from anxiety disorder seven emotions overaction of the five emotions, and the basic pathogenesis of " gas with too " is started with, and with row, hold back, fall, receive and select medicine, all recurrence due to taking drug close, and have removing heat from blood a surname logical, promoting the circulation of QI expectorant, effect of mind tranquilizing.The present invention is correlated with on the basis of Pathogenesis Theory in the cognitive traditional Chinese medical science again, according to the Chinese medicine compound monarch principles of formulating prescriptions, gives full play to the compound drug action of compositions.Existing calmness acts on relaxing, non-sleeping again, more can not cause the dyskinesia.Long-term taking is without additive, and safety is good.Cure mainly the depressed stagnation of phlegm of anxiety disorder patient, malaise.Both can be used as drug combination antianxity, also can be used for maintenance phase, or prevention of recurrence medication.And for being secondary to the anxiety of physical disease.Be applicable to symptom changeable, various types of anxiety disorder patient in combination medication of course of disease delay, or maintenance phase medication, or prevention of recurrence.Be particularly suitable for the use of the physical disease such as anxiety and tumor, apoplexy, coronary heart disease mood regulation sick altogether.Its clinical application has a extensive future.
Detailed description of the invention
Embodiment 1(model case one)
Qiu's ××, women, 45 years old, main suit's anxiety and tense, frightened worried, the June such as palpitation and restlessness
Nineteen ninety marries, infertile for many years after marriage, seeks medical advice everywhere.In January, 1997 does diagnosis dilatation and curettage of uterine, and without significant discomfort in art, but postoperative vaginal is bled.Patient is more panic, listens colleague to say the possibility of cancer, and more nervous, sense is nervous, tachypnea.After 2 weeks, treated stopped bleeding, but patient still fear suffer from incurable disease, being afraid of again to give birth to can be abandoned by husband.Tell insomnia, agitation, but still can adhere to work and manage household affairs.Exacerbation of symptoms after 3 months, and there is ictal extreme agitation, feel restless, rapid breathing, uncomfortable in chest, cardiopalmus, perspiration, xerostomia, numbness of hands and feet.Conscious meeting is gone mad, it is stupid to become, and has dying sense, and each outbreak does not continue half an hour to 1 hour not etc., almost all has outbreak every day.The outbreak intermission still has agitation, worries to send out again, but still can draw oneself up.After 5 months, symptom is more serious, without the obvious intermission, be in all day greatly alarmed among.Be reluctant that mental hospital sees a doctor, lover have to ask doctor in family, and patient catches doctor not put, and repeatedly describes the slight illness of oneself.Often look for lover noisy without reason, the discomfort of oneself is attributed to lover and is indifferent to, does not understand.Lie awake all night, also do not allow husband sleep peacefully, very harsh to husband, require that he is docile, otherwise just make a scene.Fearness listens to the radio, and is afraid of to see TV, frighteningly bothers, but around nobody feels again very lonely.See that the women of divorce or the death of one's spouse then recalls the past memories, occur " a burst of angor " in the heart.Have a worried look all day, chatter, shout " terribly ".Tear hair time serious, two handss do not stay in abdominal part and rub, and cause epigastrium skin rubefaction, swelling.So far, work has been completely lost and the ability of managing household affairs.
Previously body is good for: premorbid personality is irritable, irritability, eager to do well in everything stubbornness, to attack well, intolerant, suspiciously to worry too much, do things irresolute.Deny spiritedness illness and hereditary history in family.
Physical examination: no abnormality seen.Thready and stringy pulse, red tongue, yellow fur.
Interview: consciousness is clear, and instrument is whole, contact cooperation, vainly hope without hallucination, anxiety, attention cannot be concentrated, and can not keep quite, action is many, rubs hands to stamp foot, walk up and down.
Lab testing: blood, routine urinalysis, T3T4, hepatic and renal function is all normal; Electrocardioscopy is normal; Rabat is normal;
Psychometry before treatment:
1, the factorial analysis of SCL-90: somatization 2.8, forces 1.8, and interpersonal sensitivity 2.1, and depressed 2.3, anxiety 4.0, hostile 2.1, other are 3.1 years old.Total score: 18.2, suggest severe anxiety.
2, Analysisof Self-rating Anxiety Scale (SAS): standard scores 75 points, prompting anxiety.
3, Ganzangxiang of TMC emotion rating scale (ERSG): the Liver Channel factor 8.9, anxiety neurosis 18.9, depression factor 15.6, prompting has obvious anxiety.
(note: ERSG, by establishments such as Hu Suiyu, Wang Zhe, Cai Taisheng, is shown in Zhang Zuoji chief editor " behavioral medicine scale handbook "
Chinese medical electronics audio & video publisher.2005 1 edition 239 pages-243 pages)
Diagnosis: extensively anxiety.Differential diagnosis in tcm: depressed stagnation of phlegm.
Administration: the oral agents of the Chinese medicine composition of angst resistance effect: Cortex Moutan 12g Radix Paeoniae Alba 18g Olibanum 6g Fructus Alpiniae Oxyphyllae 7g Flos Inulae 7g(totally 42 doses of confessions goes to a doctor for 4 times).
After taking medicine, sleep recovers normal, has and feels nervous, easily loosen, can normally manage household affairs, get along as usual with household though even.
Psychometry: SCL-90 after treatment: somatization 1.2, force 1.1, interpersonal sensitivity 1.0, depressed 1.0, anxiety 1.2, hostile 0.9, other 1.3, deduction rate is 57.69%.
SAS:36, deduction rate is 52.0%.
ERSG: the Liver Channel factor 4.1, anxiety neurosis 8.7, depression factor 8.5, deduction rate is 50.0%.
Observe 42 days effectively clinical.
Embodiment 2(model case two)
Old ××, male, 32 years old, engineer.Because anxiety is feared without reason, cause health not good, cannot normally work medical.Patient usually feels nervous over the past half year, gratuitous striking fear into and nervous, worries.What think at heart is nearly all the thing of worry, as late in feared working, worries unemployed, is afraid of bad etc. with Peer Relationships process.To such an extent as to be difficult to fall asleep, cannot normally work.Feel that oneself stress is large, colleague also always says that oneself work is too nervous, but oneself does not think that this is problem, and work strain should be energetic performance.Also once attempting listens to the music allows and oneself loosens, and can still cannot focus one's attention on, and is also difficult to eliminate more and more significantly worried.Health is not good, usually feels uncomfortable in chest, and indefinite the aching of whole body migration, muscular tone, is sorely distressed.Examination in hospital is gone but not find any organic disease.
Previously body is good for: premorbid personality is irritable, and doing work, it is perfect to require.Deny spiritedness illness and hereditary history in family.
Physical examination: no abnormality seen, stringy pulse, red tongue, yellow fur.
Interview: mental awareness is clear, instrument is rectified, contact cooperation, and attention owes to concentrate, and requires urgent.
Lab testing: blood, routine urinalysis, T3T4, hepatic and renal function is all normal; Electrocardioscopy is normal; Rabat is normal.
Psychometry before treatment: 1, SCL-90 test: somatization 1.8, force 1.9, interpersonal sensitivity 2.5, depressed 1.6, anxiety 3.9, hostile 2.0, other 3.3, total score 17.
2, SAS: standard scores 74, suggest severe anxiety.
3, ERSG: the Liver Channel factor 10.4 anxiety neurosis 16.6 depression factor 15.1 points out obvious anxiety.
Diagnosis: extensively anxiety.Dialectical: depressed stagnation of phlegm.
Administration: the oral agents of the Chinese medicine composition of angst resistance effect: Cortex Moutan 15g Radix Paeoniae Alba 15g Olibanum 12g Fructus Alpiniae Oxyphyllae 9g Flos Inulae 10g(totally 42 doses of confessions goes to a doctor for 4 times).
Symptom after taking medicine obviously improves, and sleep recovers normal, and systemic pain disappears substantially, has nervous, can control though even, recovers normally to work.
Psychometry after treatment: 1, SCL-90 test: somatization 0.7, force 0.9, interpersonal sensitivity 1.5, depressed 1.0, anxiety 1.7, hostile 1.0, other 1.2, total score 8.0.Deduction rate is 52.94%.
2, SAS: standard scores 36, deduction rate is 51.35%.
3, ERSG: the Liver Channel factor 7.0, anxiety neurosis 7.6 depression factor 6.2, deduction rate is 50.6%, observe 42 days effectively clinical.
Embodiment 3(model case three)
Willow ××, female, 34 years old, accounting.Main suit: psychentonia, sleeps poor, inferior belly gas pain, frequent micturition, worries enuresis half a year.Patient is because of first love failure, and normal sense occurs psychentonia suddenly, is afraid of to talk with people, sleeps poor, repeatedly occur inferior belly gas pain, frequent micturition, usually worries the wet trousers of urine, especially feels worry when going out.But never there is the enuresis.Once repeatedly medical urinary system training, every inspection is all normal, and doctor's advice is loosened, loosen again, oneself also attempt to make great efforts to do, but It dones't help the situation.Have a hunch that health worse and worse, and nervous outbreak is frequent.Colleague is also refused to introducing object, thinks and will wait until that the healthy ability of physical recovery is in love.
Previously body is good for, and works careful and responsible, and accounting event is familiar with, and Meeting People is always blushed.Be a cup too low in family disease and hereditary medical history.
Physical examination: no abnormality seen, thready pulse, red tongue, yellow fur.
Interview: mental awareness is clear, clothing is neat, anxiety of answering a question, blushes; Can not loosen, seek medical advice anxious
Lab testing: blood, routine urinalysis, T3T4, hepatic and renal function is all normal; Electrocardioscopy is normal; Rabat is normal, Abdominal B type ultrasonography no abnormality seen.
Psychometry before treatment: 1, SCL-90 Cause of body 1.9, force 1.9, interpersonal sensitivity 2.9, depressed 1.5, anxiety 4.1, hostile 2.5, other 3.1, total score 17.6, points out obvious anxiety
2, SAS standard scores: 69
3, the ERSG Liver Channel factor 11.7, anxiety neurosis 17.5 depression factor 14.1
Diagnosis: extensively anxiety.Dialectical: depressed stagnation of phlegm.
Administration: the oral agents of the Chinese medicine composition of angst resistance effect: Cortex Moutan 10g Radix Paeoniae Alba 18g Olibanum 6g Fructus Alpiniae Oxyphyllae 10g Flos Inulae 7g(totally 42 doses of confessions goes to a doctor for 4 times).
Frequent micturition basic controlling after taking medicine, no longer refuses other people and introduces object.
Psychometry after treatment: 1, SCL-90: Cause of body 1.8, force 1.0, interpersonal sensitivity 1.4, depressed 0.9, anxiety 0.8, hostile 0.7, other 1.1, total score 17.6, deduction rate is 52.3%.
2, SAS standard scores: 35, deduction rate is 49.28%
3, the ERSG Liver Channel factor 6.3, anxiety neurosis 7.6 depression factor 5.5, deduction rate is 55.2%, observe 42 days effectively clinical.
Embodiment 4(zoopery one)
This compositions decoct (sample medicinal liquid) acute toxicity test:
Sample medicinal liquid and dosage: Cortex Moutan 18g Radix Paeoniae Alba 18g Olibanum 12g Fructus Alpiniae Oxyphyllae 10g Flos Inulae 10g
Sample medicinal liquid gives mouse stomach with Cmax (crude drug) 308%, gavage volume is 0.4ml/10g body weight, 1 administration, this is mice dosage 132.2g/kg crude drug, suitable 70kg is grown up 126.9 times of clinical application amount (68 grams), Continuous Observation 10 days, animal diet followed, activity, hair color feces are all normal, without animal dead.After experiment, body weight and blank group contrast, no significant difference (P>0.05).Dissect animal, the internal organs such as perusal mouse core, liver, lung, kidney are showed no exception, show that sample medicinal liquid maximum tolerated dose is 132.2g/kg crude drug, without acute toxic reaction.
Embodiment 5(zoopery two)
Sample medicinal liquid gavages, the impact on normal spontaneous activity in mice:
Sample medicinal liquid I and dosage: Cortex Moutan 10g Radix Paeoniae Alba 10g Olibanum 6g Fructus Alpiniae Oxyphyllae 7g Flos Inulae 7g
Sample medicinal liquid II and dosage: Cortex Moutan 18g Radix Paeoniae Alba 18g Olibanum 12g Fructus Alpiniae Oxyphyllae 10g Flos Inulae 10g
Select 18-22g Kunming mouse, male and female are regardless of, and are divided into blank group at random, gavage normal saline; Buspirone matched group (converting for 30mg/ days by adult); Sample medicinal liquid I group (40g/ days. adult's clinical equivalent amount), sample medicinal liquid II group (68g/ days. adult's clinical equivalent amount), often organize 10, after gastric infusion 60 minutes, adopt direct visual perception method, measure walking time (S) in mice 2 minutes, two forelimb upwards praises number of times (observing 3 times altogether), in table 1.Result show sample medicinal liquid and buspirone all have inhibitory action to spontaneous activity in mice, and part is proved this compositions and had the sedation that relaxes.
Table 1 sample medicinal liquid is on the impact (n=10, X ± S) of each group of spontaneous activity in mice
Δ and blank group compare: compare before P<0.01* and administration: P<0.01
Embodiment 6(zoopery three)
Anti-stress is tested: sample medicinal liquid gavages the impact on mice normal pressure resistant anoxia:
Sample medicinal liquid I, II and dosage lead to zoopery two.
Select 18-22g Kunming clock mice, male and female are certificate not, is divided into blank group at random, buspirone matched group (converting for 30mg/ days by adult); Sample medicinal liquid I group (40g/ days. adult's clinical equivalent amount), sample medicinal liquid II group (68g/ days. adult's clinical equivalent amount), often organize 8.After gastric infusion 30 minutes, only put into 200ml ground wide mouthed bottle by single for mice, covering tightly sealing, immediately timing, took respiratory arrest as index, observes the time (dividing) of mice death because of anoxia.Result show sample medicinal liquid comparatively blank group, buspirone group is compared, and is improved the effect of mice normal pressure resistant anoxia, points out this compositions to have certain anti-stress effect.
Table 2 sample medicinal liquid is on the impact (dividing, X ± S) of mice normal pressure resistant anoxia
Δ compares with blank group: P<0.01* compares with buspirone group: P<0.01.
Claims (5)
1. have a Chinese medicine composition for angst resistance effect, it is characterized in that, described Chinese medicine composition is made up of the crude drug of following weight portion:
Cortex Moutan 10 ~ 18
The Radix Paeoniae Alba 10 ~ 18
Olibanum 6 ~ 12
Fructus Alpiniae Oxyphyllae 7 ~ 10
Flos Inulae 7 ~ 10.
2. Chinese medicine composition as claimed in claim 1, it is characterized in that, described Chinese medicine composition is made up of the crude drug of following weight portion:
Cortex Moutan 10 ~ 15
The Radix Paeoniae Alba 15 ~ 18
Olibanum 6 ~ 12
Fructus Alpiniae Oxyphyllae 7 ~ 10
Flos Inulae 7 ~ 10.
3. Chinese medicine composition as claimed in claim 2, it is characterized in that, described Chinese medicine composition is made up of the crude drug of following weight portion:
Cortex Moutan 10 ~ 15
The Radix Paeoniae Alba 15 ~ 18
Olibanum 6 ~ 12
Fructus Alpiniae Oxyphyllae 7 ~ 9
Flos Inulae 7 ~ 9.
4. Chinese medicine composition as claimed in claim 3, it is characterized in that, described Chinese medicine composition is made up of the crude drug of following weight portion:
Cortex Moutan 12 ~ 15
The Radix Paeoniae Alba 15 ~ 18
Olibanum 6 ~ 12
Fructus Alpiniae Oxyphyllae 7 ~ 9
Flos Inulae 7 ~ 9.
5. the Chinese medicine composition as described in any one of Claims 1-4, is characterized in that, the dosage form of described Chinese medicine composition is Chinese herbs decoction.
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| CN101310740A (en) * | 2007-05-24 | 2008-11-26 | 上海欣生源药业有限公司 | Anti-anxiety compound traditional Chinese medicine and preparation method thereof |
| CN101708281A (en) * | 2009-12-10 | 2010-05-19 | 袁尚礼 | Chinese medicinal preparation for nourishing heart and tranquilizing mind and preparation method thereof |
| CN102949513A (en) * | 2012-11-14 | 2013-03-06 | 西安福安创意咨询有限责任公司 | Traditional Chinese medical health protection product for alleviating anxiety neurosis and preparation method thereof |
| CN103599471A (en) * | 2013-10-21 | 2014-02-26 | 张霞 | Traditional Chinese medicine composition for young female depression |
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| CN101310740A (en) * | 2007-05-24 | 2008-11-26 | 上海欣生源药业有限公司 | Anti-anxiety compound traditional Chinese medicine and preparation method thereof |
| CN101708281A (en) * | 2009-12-10 | 2010-05-19 | 袁尚礼 | Chinese medicinal preparation for nourishing heart and tranquilizing mind and preparation method thereof |
| CN102949513A (en) * | 2012-11-14 | 2013-03-06 | 西安福安创意咨询有限责任公司 | Traditional Chinese medical health protection product for alleviating anxiety neurosis and preparation method thereof |
| CN103599471A (en) * | 2013-10-21 | 2014-02-26 | 张霞 | Traditional Chinese medicine composition for young female depression |
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