CN104001057B - For treating the heart schizoid medicine of kidney disorder type and preparation method thereof - Google Patents

Abstract

The invention discloses a kind of for treating the heart schizoid medicine of kidney disorder type and preparation method thereof, wherein medicine includes endo-medicine and external used medicine, endo-medicine includes following raw medicinal material: Mirabilitum crystallina, Fructus Gardeniae, Folium Bambusae, Rhizoma Coptidis, Rhizoma Bistortae, the Radix Rehmanniae, Radix Scrophulariae, Cornu Bubali, Lapis Micae Aureus, Pheretima, Radix Polygoni Multiflori Preparata, Flos Rosae Rugosae, FLOS MUME, Nidus Vespae, Radix Ranunculi Ternati, Bombyx Batryticatus, Succus Bambusae, Concretio Silicea Bambusae, Radix Platycodonis, Bulbus Lilii, Radix Asparagi, Rhizoma Polygonati Odorati, Rhizoma Polygonati, Fructus Lycii, Fructus Ligustri Lucidi, Fructus Mori, Carapax Et Plastrum Testudinis, Folium Artemisiae Argyi, Radix Trichosanthis, Semen Ziziphi Spinosae, Semen Platycladi, Rhizoma et radix valerianae, Radix Polygalae and Rhizoma Acori Graminei；External used medicine includes following raw medicinal material: Radix Angelicae Sinensis, Pericarpium Zanthoxyli, Radix Polygalae, Cortex Cinnamomi, Amylum Nelumbinis Rhizomatis, the Rhizoma Atractylodis Macrocephalae, Aloe and the Radix Aucklandiae.The invention has the beneficial effects as follows: the present invention utilizes Traditional Chinese medical theory, based on nourishing YIN for attracting YANG, restoring normal coordination between the heart and kidney, treatment heart kidney disorder type schizophrenia has rapid-action, determined curative effect, safety is high, the advantage that has no side effect and not easily recur.

Description

For treating the heart schizoid medicine of kidney disorder type and preparation method thereof

Technical field

The present invention relates to pharmaceutical technology, particularly relate to a kind of for treating the heart schizoid medicine of kidney disorder type and preparation method thereof.

Background technology

How slow person between twenty and fifty schizophrenia is the major psychosis that one group of cause of disease is not bright, or subacute onset, often shows as the syndrome that symptom is different clinically, relates to the inharmonious of many-sided obstacles such as sensory perception, thinking, emotion and behavior and ergasia.The general Clear consciousness of patient, intelligence is normal, but some patients there will be the infringement of cognitive function in lysis.The course of disease is generally delayed, and in recurrent exerbation, increases the weight of or worsens, and decline and mental handicap finally occurs in some patients, but some patients can keep recovery from illness or the state that is almost recovered after treatment.

The clinical syndrome that schizophrenia is made up of one group of syndrome, it is multifactorial disease.Although at present that the understanding of its cause of disease is still not bery clear and definite, but the effect that development occurs of disease is known together by the undesirable element of the susceptible quality of individual mind and outside social environment by everybody.Being the generation that all causes disease possibly through inherent biological factor combined effect of susceptible quality or outside undesirable element, the factor of different its morbidities of patient is likely to comparatively important in a certain respect.

Schizoid clinical symptoms complexity is various, can relate to the aspects such as sensory perception, thinking, emotion, volitional behavior and cognitive function, and between individuality, symptom is widely different, even if same patient is likely in different phase or stadium shows different symptoms.(1) sensory perception obstacle, schizophrenia may occur in which multiple sensory perception obstacle, and the most prominent sensory perception obstacle is hallucination, and including auditory hallucination, photis, olfactory hallucination, gustatory hallucination and tactile hallucination etc., and auditory hallucination is most commonly seen.(2) thought disturbance, thought disturbance is schizoid core symptom, mainly includes form of thinking obstacle and content of thought obstacle.Form of thinking obstacle, with thinking associative process obstacle for main manifestations, associates the obstacle of active procedure (amount, speed and form), the thinking association aspect such as continuity and logicality including thinking.Vain hope is content of thought obstacle the most common, most important.The vain hope the most often occurred has delusion of persecution, delusion of relation, delusion of influence, delusion of jealousy, the delusion of grandeur, non-descent delusion etc..According to estimates, there is delusion of persecution in the schizophrenic up to 80%, delusion of persecution can show as insecurity in various degree, offerd medicine or by murder etc. as being monitored, be ostracised, worrying, under vain hope impact, patient can make defence or aggression, additionally, passive experience is also comparatively prominent with some patients, the thinking of patient, emotion and behavior are produced impact.(3) affective disorder, apathy and emotional responses is inharmonious is the modal affective symptom of schizophrenic, additionally, the affective symptom such as incoordination is excited, irritability, depression and anxiety is also more typically.(4) will and behavior disorder, the hypobulia of most of patients even lacks, show as movable minimizing, peel off and stay alone, behavior is passive, lacks due enthusiasm and initiative, working and learning interest is gone down, it is indifferent to future, to clearly not intending in the future, some patient is likely to have some plans and plan, but seldom performs.(5) cognitive dysfunction, in schizophrenic, the incidence rate of cognitive defect is high, and cognitive dysfunction occurs in about 85% patient, such as information processing and selective attention, working memory, short term memory and the cognitive defect such as study, execution function.Certain dependency is there is between cognitive defect symptom and other psychotic symptoms, the cognitive defect symptom of patient as obvious in form of thinking obstacle becomes apparent from, the cognitive defect symptom of the obvious patient of negative symptoms becomes apparent from, and cognitive defect is likely to relevant with the generation of some positive symptom etc..Cognitive defect is it may happen that (such as prodromal period) before psychotic symptoms is clear, or sharply decline along with the appearance of psychotic symptoms, or extend along with the course of disease and progressively fail, it was initially believed that Patients with Chronic Schizophrenia becomes apparent from than the cognitive defect of first episode schizophrenia.

At present, western medical treatment schizophrenia common drug has the long-acting injections such as risperidone, 9-hydroxy-risperidone, western medical treatment schizophrenia is longer for the course for the treatment of, and bad should be more, is easily generated drug resistance, medicament categories is less, select limitation, and expensive, patient economy burden is heavier, patient faces society for a long time and psychological problems also brings along stress, even increase the weight of the state of an illness, bring considerable distress to patient.Urgent clinical needs one can effectively alleviate schizoid medicine, to meet the demand of patient.

China's Schizophrenia Treated by TCM is with a long history, has the advantage of uniqueness, it is possible to make up the deficiency of doctor trained in Western medicine；Utilize Traditional Chinese medical theory, pay attention to organic conception, be particular about determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs simultaneously, while the overall system of conditioning, recovery god's machine, " treating different diseases with the same therapeutic principle ", " treating the same disease with different methods ", under total Therapeutic Principle, for same class disease individualized treatment, targeting is relatively strong, evident in efficacy, the course for the treatment of is shorter, is not likely to produce drug resistance；Selected natural Chinese medicines material, safely, effectively, toxic and side effects is relatively low, and cost price is low, can carry out market development to meet clinical demand, improves the quality of life etc. of patient.

The traditional Chinese medical science thinks that schizophrenia belongs to the categories such as motherland's medical science " mad disease ".Mad disease is many because of overaction of the five emotions, or caused by congenital heredity, with phlegm-fire blood stasis, inaccessible thinking, god's machine entanglement is basic pathogenesis, clinical excited with spirit, manic uneasiness, scolding is scolded and is ruined thing, dynamic and many anger, even kill a person with a knife a kind of common multiple psychosis into feature, therefore distinguish that its clinical syndrome is divided into: phlegm-fire disturbing spirit, expectorant knot blood stasis, obstruction of the orifices by blood stasis, impairment of YIN contained by fire, the types such as heart kidney imbalance, heart kidney disorder type therein: mad disease is prolonged for a long time, time when making only, gesture is lighter, talk tactlessly to act recklessly, that exhales can make by oneself, bedroom uneasiness is slept, tired impatience of sighing, xerostomia dyschezia, red tip of the tongue no fur has breakaway, thready and rapid pulse.

Summary of the invention

The technical problem to be solved is in that, one is provided to be used for treating the heart schizoid medicine of kidney disorder type and preparation method, the present invention utilizes Traditional Chinese medical theory, pay attention to organic conception, be particular about determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs simultaneously, in conditioning entirety it is, while recovering god's machine, " treating different diseases with the same therapeutic principle ", " treating the same disease with different methods ", under total Therapeutic Principle, for heart kidney disorder type schizophrenic subjectsization treatment, with nourishing YIN for attracting YANG, restoring normal coordination between the heart and kidney is main, treatment heart kidney disorder type schizophrenia has rapid-action, determined curative effect, safety is high, the advantage having no side effect and not easily recur.

In order to solve above-mentioned technical problem, the invention provides a kind of for treating the heart schizoid medicine of kidney disorder type, described medicine includes endo-medicine and external used medicine, described endo-medicine includes following raw medicinal material: Mirabilitum crystallina, Fructus Gardeniae, Folium Bambusae, Rhizoma Coptidis, Rhizoma Bistortae, the Radix Rehmanniae, Radix Scrophulariae, Cornu Bubali, Lapis Micae Aureus, Pheretima, Radix Polygoni Multiflori Preparata, Flos Rosae Rugosae, FLOS MUME, Nidus Vespae, Radix Ranunculi Ternati, Bombyx Batryticatus, Succus Bambusae, Concretio Silicea Bambusae, Radix Platycodonis, Bulbus Lilii, Radix Asparagi, Rhizoma Polygonati Odorati, Rhizoma Polygonati, Fructus Lycii, Fructus Ligustri Lucidi, Fructus Mori, Carapax Et Plastrum Testudinis, Folium Artemisiae Argyi, Radix Trichosanthis, Semen Ziziphi Spinosae, Semen Platycladi, Rhizoma et radix valerianae, Radix Polygalae and Rhizoma Acori Graminei；

Described external used medicine includes following raw medicinal material: Radix Angelicae Sinensis, Pericarpium Zanthoxyli, Radix Polygalae, Cortex Cinnamomi, Amylum Nelumbinis Rhizomatis, the Rhizoma Atractylodis Macrocephalae, Aloe and the Radix Aucklandiae.

nullIn described endo-medicine, the parts by weight of each raw medicinal material are: Mirabilitum crystallina 5-9 weight portion、Fructus Gardeniae 10-15 weight portion、Folium Bambusae 10-20 weight portion、Rhizoma Coptidis 15-25 weight portion、Rhizoma Bistortae 10-15 weight portion、Radix Rehmanniae 5-15 weight portion、Radix Scrophulariae 10-15 weight portion、Cornu Bubali 3-9 weight portion、Lapis Micae Aureus 3-10 weight portion、Pheretima 10-15 weight portion、Radix Polygoni Multiflori Preparata 10-20 weight portion、Flos Rosae Rugosae 15-25 weight portion、FLOS MUME 10-15 weight portion、Nidus Vespae 10-25 weight portion、Radix Ranunculi Ternati 5-10 weight portion、Bombyx Batryticatus 15-25 weight portion、Succus Bambusae 10-15 weight portion、Concretio Silicea Bambusae 5-15 weight portion、Radix Platycodonis 10-20 weight portion、Bulbus Lilii 15-25 weight portion、Radix Asparagi 10-20 weight portion、Rhizoma Polygonati Odorati 5-15 weight portion、Rhizoma Polygonati 10-15 weight portion、Fructus Lycii 15-25 weight portion、Fructus Ligustri Lucidi 10-17 weight portion、Fructus Mori 15-25 weight portion、Carapax Et Plastrum Testudinis 3-8 weight portion、Folium Artemisiae Argyi 10-15 weight portion、Radix Trichosanthis 5-10 weight portion、Semen Ziziphi Spinosae 10-25 weight portion、Semen Platycladi 15-25 weight portion、Rhizoma et radix valerianae 9-16 weight portion、Radix Polygalae 10-15 weight portion and Rhizoma Acori Graminei 5-12 weight portion；

In described medicine for external use thing, the parts by weight of each raw medicinal material are: Radix Angelicae Sinensis 10-20 weight portion, Pericarpium Zanthoxyli 5-10 weight portion, Radix Polygalae 5-12 weight portion, Cortex Cinnamomi 5-8 weight portion, Amylum Nelumbinis Rhizomatis 5-20 weight portion, Rhizoma Atractylodis Macrocephalae 5-9 weight portion, Aloe 10-20 weight portion and Radix Aucklandiae 5-12 weight portion.

nullIn described endo-medicine, the parts by weight of each raw medicinal material are preferably: Mirabilitum crystallina 7 weight portion、Fructus Gardeniae 12 weight portion、Folium Bambusae 15 weight portion、Rhizoma Coptidis 21 weight portion、Rhizoma Bistortae 12 weight portion、The Radix Rehmanniae 7 weight portion、Radix Scrophulariae 12 weight portion、Cornu Bubali 5 weight portion、Lapis Micae Aureus 7 weight portion、Pheretima 12 weight portion、Radix Polygoni Multiflori Preparata 15 weight portion、Flos Rosae Rugosae 22 weight portion、FLOS MUME 12 weight portion、Nidus Vespae 17 weight portion、Radix Ranunculi Ternati 7 weight portion、Bombyx Batryticatus 19 weight portion、Succus Bambusae 12 weight portion、Concretio Silicea Bambusae 11 weight portion、Radix Platycodonis 15 weight portion、Bulbus Lilii 21 weight portion、Radix Asparagi 15 weight portion、Rhizoma Polygonati Odorati 11 weight portion、Rhizoma Polygonati 12 weight portion、Fructus Lycii 21 weight portion、Fructus Ligustri Lucidi 14 weight portion、Fructus Mori 21 weight portion、Carapax Et Plastrum Testudinis 6 weight portion、Folium Artemisiae Argyi 13 weight portion、Radix Trichosanthis 6 weight portion、Semen Ziziphi Spinosae 22 weight portion、Semen Platycladi 21 weight portion、Rhizoma et radix valerianae 12 weight portion、Radix Polygalae 12 weight portion and Rhizoma Acori Graminei 7 weight portion；

In described medicine for external use thing, the parts by weight of each raw medicinal material are preferably: Radix Angelicae Sinensis 15 weight portion, Pericarpium Zanthoxyli 7 weight portion, Radix Polygalae 8 weight portion, Cortex Cinnamomi 6 weight portion, Amylum Nelumbinis Rhizomatis 12 weight portion, the Rhizoma Atractylodis Macrocephalae 7 weight portion, Aloe 15 weight portion and the Radix Aucklandiae 7 weight portion.

nullIn described endo-medicine, the parts by weight of each raw medicinal material can also be preferably: Mirabilitum crystallina 5 weight portion、Fructus Gardeniae 15 weight portion、Folium Bambusae 20 weight portion、Rhizoma Coptidis 25 weight portion、Rhizoma Bistortae 10 weight portion、The Radix Rehmanniae 5 weight portion、Radix Scrophulariae 10 weight portion、Cornu Bubali 3 weight portion、Lapis Micae Aureus 10 weight portion、Pheretima 10 weight portion、Radix Polygoni Multiflori Preparata 10 weight portion、Flos Rosae Rugosae 25 weight portion、FLOS MUME 15 weight portion、Nidus Vespae 25 weight portion、Radix Ranunculi Ternati 5 weight portion、Bombyx Batryticatus 25 weight portion、Succus Bambusae 10 weight portion、Concretio Silicea Bambusae 5 weight portion、Radix Platycodonis 10 weight portion、Bulbus Lilii 25 weight portion、Radix Asparagi 10 weight portion、Rhizoma Polygonati Odorati 15 weight portion、Rhizoma Polygonati 10 weight portion、Fructus Lycii 15 weight portion、Fructus Ligustri Lucidi 10 weight portion、Fructus Mori 15 weight portion、Carapax Et Plastrum Testudinis 3 weight portion、Folium Artemisiae Argyi 15 weight portion、Radix Trichosanthis 10 weight portion、Semen Ziziphi Spinosae 25 weight portion、Semen Platycladi 25 weight portion、Rhizoma et radix valerianae 16 weight portion、Radix Polygalae 10 weight portion and Rhizoma Acori Graminei 5 weight portion；

In described medicine for external use thing, the parts by weight of each raw medicinal material can also be preferably: Radix Angelicae Sinensis 20 weight portion, Pericarpium Zanthoxyli 10 weight portion, Radix Polygalae 5 weight portion, Cortex Cinnamomi 8 weight portion, Amylum Nelumbinis Rhizomatis 15 weight portion, the Rhizoma Atractylodis Macrocephalae 9 weight portion, Aloe 20 weight portion and the Radix Aucklandiae 12 weight portion.

In order to better realize foregoing invention purpose, the invention provides a kind of preparation method for treating the heart schizoid medicine of kidney disorder type, the dosage form of described endo-medicine is oral solutions, and its preparation method comprises the following steps:

The first step, Fructus Gardeniae, Folium Bambusae, Pheretima, Radix Polygoni Multiflori Preparata and Flos Rosae Rugosae are mixed, adding relative to mixture 3 times～5 times amount determining alcohol is the ethanol of 55%～65%, reflux, extract, 2～4 times, each 2 hours～3 hours, filters, filtrate merges, reclaiming ethanol, being concentrated into 70 DEG C of relative densities is the mastic of 1.30～1.32, standby；

Second step, is mixed in proportion surplus stock medical material, adds relative to mixture 3～5 times amount water, boils 2～4 hours, filters, and being concentrated into 70 DEG C of relative densities is the mastic of 1.27～1.29；

3rd step, the described mastic mixing first step, second step obtained, 55 DEG C～65 DEG C reduced vacuum dry, and get dry extract powder；

4th step, added ethanol in the described dried cream powder the 3rd step obtained, obtains containing alcohol mastic, and the alcohol content of described containing alcohol mastic is 65%～70%；Described containing alcohol mastic being sequentially carried out chilling treatment, precipitation process, filtration treatment, recovery Ethanol Treatment, obtains dealcoholysis mastic, wherein, the chilling treatment time is 30～40 hours；

5th step, will add cane sugar powder, activated carbon in described dealcoholysis mastic, be sequentially carried out heat treated, filtration treatment, dilution process, obtain semi-finished product；The weight ratio of described dealcoholysis mastic and described cane sugar powder is 1: 0.1～0.3；The weight ratio of described dealcoholysis mastic and described activated carbon is 1: 0.001～0.002；The time of described heat treated is 20～40 minutes, and temperature is 100 DEG C～110 DEG C；

6th step, the more described semi-finished product that the 5th step obtains are sequentially carried out filtration treatment, embedding process, sterilization treatment, obtain described Chinese medicine preparation oral liquid finished product.

The dosage form of described endo-medicine is tablet, and its preparation method comprises the following steps:

The first step, is mixed in proportion described each raw medicinal material, adds the ethanol that determining alcohol is 85%～95% relative to mixture quality 2～4 times, is heated to reflux 1～3 hour, extracts, and filters and obtains the first extracting solution；Filter the medicinal residues obtained and add the ethanol that determining alcohol is 85%～95% relative to described medicinal residues quality 1～2 times, be heated to reflux 1～3 hour, extract, filter and obtain the second extracting solution；First extracting solution and the second extracting solution being merged, concentrating under reduced pressure removes alcohol solvent, dry, it is thus achieved that dry cream；

Second step, is placed in super micron mill by the dry cream that the first step obtains and pulverizes 1～2 hour, pulverizes, sieves, it is thus achieved that the micropowders of 300 order～400 orders；

3rd step, the micropowders that second step is obtained, add relative to the microcrystalline Cellulose of its quality 0.1～0.3 times, 0.05～0.15 times of lactose, the starch of 0.1～0.3 times, sieve, mix homogeneously, granulate, dry, add relative to 0.005～0.05 times of magnesium stearate of micropowders quality, granulate, tabletting, makes.

The dosage form of described external used medicine is navel patch, and its preparation method comprises the following steps:

The first step, is mixed in proportion described each raw medicinal material, is ground into the powder of 40 order～60 orders, adds the ethanol that determining alcohol is 85～95% relative to mixture quality 2～4 times, is heated to reflux 1～3 hour, extracts, and filters and obtains the first extracting solution；Filter the medicinal residues obtained and add the ethanol that determining alcohol is 85～95% relative to described medicinal residues quality 1～2 times, be heated to reflux 1～3 hour, extract, filter and obtain the second extracting solution；First extracting solution and the second extracting solution being merged, concentrating under reduced pressure removes alcohol solvent, dry, it is thus achieved that dry cream, is ground into the powder of 100 order～200 orders；

Second step, dissolves stearic acid heating, and being maintained at temperature is 70 DEG C～80 DEG C, it is thus achieved that stearic acid liquid；It addition, potassium hydroxide, glycerol, ethyl hydroxybenzoate and distilled water to be pressed the part by weight mixing of 5:500:1:600, heating, maintain the temperature at 70 DEG C～80 DEG C, it is thus achieved that distilled water mixed liquor；Stearic acid liquid is slowly added in distilled water mixed liquor according to the part by weight of 1:100, stirs cooling, it is thus achieved that substrate simultaneously；

3rd step, the substrate obtained to second step adds the Chinese medicinal powder that the first step of equivalent obtains, and is constantly ground to uniformly, and heating obtains sticky paste, granulates, and after drying, obtains pill, coordinates medical proof fabric or special navel paster that pill is attached to umbilicus place.

The invention has the beneficial effects as follows: the present invention utilizes Traditional Chinese medical theory, pay attention to organic conception, be particular about determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs simultaneously, while the overall system of conditioning, recovery god's machine, " treating different diseases with the same therapeutic principle ", " treating the same disease with different methods ", under total Therapeutic Principle, for heart kidney disorder type schizophrenic subjectsization treatment, based on nourishing YIN for attracting YANG, restoring normal coordination between the heart and kidney, treatment heart kidney disorder type schizophrenia has rapid-action, determined curative effect, safety is high, the advantage that has no side effect and not easily recur.

Detailed description of the invention

Umbilicus, Chinese medicine acupoint is also known as " Shenque ".It is connected with the human body twelve regular channels, the vital organs of the human body communicate, and the traditional Chinese medical science is thought, umbilicus is heart kidney traffic " door ".So-called umbilicus treats (Hilumtherapy), it is simply that medicine directly being applied ointment or plaster or treats in patient's umbilical part by the method such as moxa-moxibustion, hot compress, exciting QI of channels and collaterals, promoting flow of QI and blood, conditioning viscera, in order to prevent and to treat a kind of external therapy of disease.Umbilicus (i.e. SHENQUE acupoint) in abdominal part central authorities, be of human body important through cave, have very close relationship with meridians, the traditional Chinese medical science is referred to as the door of the root of twelve channels and collaterals, breathing；Shenque is lived in caves acromphalus, it is that (conception vessel is the sea of warp for an important acupuncture point of conception vessel, therefore stimulate this cave that the vital organs of the human body have adjustment effect), again because the skin ratio of umbilical part is relatively thin, nerve and blood vessel are abundanter, internal organs and blood vessel that it is supported include mould barrier film, liver, spleen, stomach, adrenal gland, ureter, bladder, therefore umbilical part through with the vital organs of the human body, the twelve regular channels, the contacting of eight extra-channel, have stronger absorption and conducting power.Moxibustion umbilicus can be controlled and faint, goes into a coma, suffers a shock clinically, therefore has excited brain, heart tonifying, the microcirculatory effect of improvement；Medicine applies umbilicus can control sweating due to debility, nervous vomiting, therefore has the effect adjusting autonomic nervous dysfunction；Moxibustion Shenque can control sexual impotence, infertile, therefore have the disorderly function of endocrine regulation；Cupping in SHENQUE acupoint, can control urticaria and allergic asthma, may act on immune system, suppresses anaphylaxis.Chinese medicine is thought, internal injury caused by excess of seven emotions, eating and drinking without temperance and congenital heredity are primary disease main pathogenics, and phlegm-fire blood stasis obturation heart and brain, imbalance of YIN and YANG, body and the spirit is out of control is its pathogenesis place., at heart and brain, there is substantial connection its sick position with liver and gall spleen.How its characteristic of disease is from the beginning of based on excess syndrome, such as the heart disturbed by phlegm-fire；Continuing, the blood that intimately burns is the stasis of blood, and refining liquid is expectorant and common expectorant knot blood stasis, obstruction of the orifices by blood stasis；With the passing of time many deficiency in origin and excess in superficiality, as fire contains yin-damaging and Qi consuming, disarmony between the heart and kidney etc..Treatment to drop (letting out) fire, eliminating phlegm, invigorate blood circulation, to have one's ideas straightened out to take stopgap measures, regulating YIN and YANG, recover god's machine to effect a permanent cure, for its basic principle, meanwhile, intensive care, it is prevented that accident is also very important principle.Medicine provided by the invention includes endo-medicine and external used medicine navel patch, oral administration and externally combine treatment heart kidney disorder type schizophrenia effect notable.

The invention provides a kind of for treating the heart schizoid medicine of kidney disorder type, described medicine includes endo-medicine and external used medicine, and described endo-medicine includes following raw medicinal material: Mirabilitum crystallina, Fructus Gardeniae, Folium Bambusae, Rhizoma Coptidis, Rhizoma Bistortae, the Radix Rehmanniae, Radix Scrophulariae, Cornu Bubali, Lapis Micae Aureus, Pheretima, Radix Polygoni Multiflori Preparata, Flos Rosae Rugosae, FLOS MUME, Nidus Vespae, Radix Ranunculi Ternati, Bombyx Batryticatus, Succus Bambusae, Concretio Silicea Bambusae, Radix Platycodonis, Bulbus Lilii, Radix Asparagi, Rhizoma Polygonati Odorati, Rhizoma Polygonati, Fructus Lycii, Fructus Ligustri Lucidi, Fructus Mori, Carapax Et Plastrum Testudinis, Folium Artemisiae Argyi, Radix Trichosanthis, Semen Ziziphi Spinosae, Semen Platycladi, Rhizoma et radix valerianae, Radix Polygalae and Rhizoma Acori Graminei；Described external used medicine includes following raw medicinal material: Radix Angelicae Sinensis, Pericarpium Zanthoxyli, Radix Polygalae, Cortex Cinnamomi, the Rhizoma Atractylodis Macrocephalae, Aloe and the Radix Aucklandiae.Wherein, Mirabilitum crystallina, Fructus Gardeniae, Folium Bambusae, Rhizoma Coptidis, Rhizoma Bistortae clearing away heat-fire；The Radix Rehmanniae, Radix Scrophulariae, Cornu Bubali nourishing YIN and clearing away heat；Lapis Micae Aureus, Pheretima, Radix Polygoni Multiflori Preparata, Flos Rosae Rugosae, FLOS MUME, the Rhizoma Atractylodis Macrocephalae, Nidus Vespae, Pericarpium Zanthoxyli, Radix Ranunculi Ternati, Bombyx Batryticatus, Succus Bambusae, Concretio Silicea Bambusae, Radix Platycodonis inducing resuscitation and resolving phlegm, heat clearing away is calmed the frightened；Radix Angelicae Sinensis, Aloe, Radix Aucklandiae Bulbus Lilii, Radix Asparagi, Rhizoma Polygonati Odorati, Rhizoma Polygonati, Fructus Lycii, Fructus Ligustri Lucidi, Fructus Mori, Amylum Nelumbinis Rhizomatis, Carapax Et Plastrum Testudinis tonifying kidney and nourishing yin, nourishing YIN and benefiting blood；Radix Trichosanthis, Folium Artemisiae Argyi, Semen Ziziphi Spinosae, Semen Platycladi, Rhizoma et radix valerianae, Radix Polygalae, Rhizoma Acori Graminei is relieving convulsion, tranquilizing by nourishing the heart.

Wherein, in above-mentioned endo-medicine, the pharmacology of each raw medicinal material is as follows:

Mirabilitum crystallina: pungent, salty, cold；GUIXIN, stomach, kidney channel." Mingyi Bielu ": " Mirabilitum crystallina, color is Muscovitum such as, and removable person is good, and salt essence is also.You Zhongshui county, raw Radix Dichroae mountain valley and Handan." Compendium of Material Medica: " controlling white urine, interior numbness, removing heat from blood pathogenic fire reducing, only have a toothache, hard tooth is bright." row calentura when curing mainly, high fever excessive thirst, laryngopharynx swelling and pain, edema, urine retention, aphtha of the mouth and tongue, carbuncle, erysipelas, scald.Mirabilitum crystallina treating disorders in five ZANG-organs six internal organs amass ripe, sky row seasonal epidemic pathogens plague fever, so that stuffy sensation with restlessness is quenched one's thirst, and curing the wound cold going mad, or abandon clothing and run.Control the wind heat heart hot-tempered, xerostomia raving, from head to foot high fever and in all poison.

Fructus Gardeniae: bitter, cold, nontoxic；Enter heart channel, Liver Channel, lung meridian, stomach warp, tri-jiao channel.Shennong's Herbal: " lead pathogen in five, pathogenic heat in the stomach gas, flushed complexion wine acne vulgaris nose, the red impetigo infections of tuberculoid leprosy." " Mingyi Bielu ": " Great Cold, nontoxic.Cure mainly the hot swelling pain of order, the big heat of breast heart intestine and small intestine, in the heart unhappiness, pathogenic heat in the stomach gas." pathogenic fire purging relieving restlessness, clearing away heat-damp and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body, cooling blood for hemostasis.Calentura is vexed, liver-fire conjunctival congestion, headache, jaundice due to damp-heat, stranguria, dysentery hematuria, aphtha of the mouth and tongue, and sore swollen toxin is sprained and swollen and ache.This product bitter cold drops clearly, can rush down clearly three burnt pathogenic fire, eliminating heart-fire and relieving restlessness, for controlling the key medicine that calentura is vexed, restlessness is not peaceful.There are effect of clear profit part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels dampness-heat in the liver and gallbladder, the available jaundice for the treatment of the liver gallbladder retention and fumigation of damp-heat inside the body, oliguria with reddish urine person.The hypotensive activity position of Fructus Gardeniae, at maincenter, mainly strengthens caused by medulla oblongata parasympathetic maincenter tensity.

Folium Bambusae: nature and flavor, sweet, it is slightly cold.Compendium of Material Medica: " removing dysphoria with smothery sensation, diuresis, relieving restlessness is quenched the thirst, and children's's pox poison, outer disease is vicious." effect clearing heat and relieving fidgetness, inducing diuresis for treating stranguria syndrome." vegetation is side just ": " expectorant is quenched the thirst.Control dysphoria with smothery sensation, cough with asthma, spit blood, the sound of vomiting of vomitting, pediatric epilepsy scared." for calentura excessive thirst, heart stomach-fire is contained.Folium Bambosae extract is a kind of bioflavonoid health care nutrient newly developed, has excellent antiradical activities and conclusive quasi-SOD activity；The blocking ability of nitrosation reaction can be compared favourably with VC；The effect of defying age, anti-stress and resisting fatigue is suitable with pollen；Blood fat reducing and cholesterolemia, antioxidative effect are identical with Folium Ginkgo extract；Antibacterial, antiinflammatory is similar to tea polyphenols with antivirus action；Relieving cough and expelling phlegm, heat-clearing and toxic substances removing effect victory Succus Bambusae one raise；And there is significant immunological enhancement, the human body resistance to poor environment and disease can be improved: also there is the Folium Bambusae delicate fragrance of good hydrothermal stability, antioxidative stabilizer and uniqueness.Without any harmful components and antinutritional factor, without toxicity, side effect, it it is a kind of very good pure natural health-care.

Rhizoma Coptidis: bitter, cold, nontoxic.GUIXIN, spleen, stomach, liver, gallbladder, large intestine channel." Yaoxing Fu ": " bitter in the mouth, flat, gas is trembled with fear, nontoxic.Sinking also, the moon is also.It is with having four: eliminating heart-fire, the shape of the epigastric fullness that disappears;Main intestinal, red except what intestinal mixed;Control order disease to break out and should use, treat skin infection head and the tail all same." function heat clearing and damp drying, eliminating fire and detoxication.For damp and hot feeling of fullness, vomitting acid regurgitation, dysentery, jaundice, unconsciousness due to high fever, be longer than the fire of removing pathogen in the heart stomach, have preventing or arresting vomiting concurrently and disappear the merit of painful abdominal mass, can be used for treating the prosperous caused dysphoria and insomnia of heart-fire, heat in blood tells nosebleed, conjunctival congestion, toothache, quenches one's thirst, carbuncle furuncle；External treatment eczema, eczema, auditory meatus is suppurated.It is burning hot that Rhizoma Coptidis (processed with wine) is apt to the clear part of the body cavity above the diaphragm housing the heart and lungs.For conjunctival congestion, aphtha.Prepared RHIZOMA COPTIDIS with rhizoma zingiberis recens juice clearing stomach stomach function regulating preventing or arresting vomiting.Tying mutually for cold and heat, damp and hot middle resistance, feeling of fullness is vomitted.Cornel Rhizoma Coptidis soothing liver-QI stomach function regulating preventing or arresting vomiting.For incoordination between the liver and stomach, vomit acid regurgitation.

Rhizoma Bistortae: bitter is cool；Return lung, liver, large intestine channel." modern Practical Chinese medicinal ": " take orally and control bloody dysentery；Rinsing the mouth makes the astringent of stomatitis；Hemorrhoid and abscess are controlled in external." " Chinese medicinal herbal ": " heat-clearing and toxic substances removing, mass dissipating and swelling eliminating.Control calentura infantile convulsion, tetany, tetanus, carbuncle scrofula, snake bite and insect sting." heat clearing away is relieving convulsion, the wet detumescence of reason.Control that calentura is frightened jerks, tetanus, bloody dysentery, carbuncle, scrofula.Rhizoma Bistortae is oozed Rhizoma Bistortae and filters clean No. 1 of the hemostasis that liquid and gelatin etc. make, and all has certain haemostatic effect for the various hemostasis experiment of dog and sheep (femoral artery cuts off, liver clip, splenectomy etc. hemorrhage).In vitro staphylococcus aureus, bacillus pyocyaneus, bacillus subtilis, escherichia coli etc. all there is antibacterial action.

The Radix Rehmanniae: sweet, cold；GUIXIN, liver, kidney channel.Shennong's Herbal: " sweet in the mouth, cold.Cure mainly folding to fall, exhausted muscle, damaging the spleen and stomach, by arthralgia due to stagnation of blood, fill out bone marrow, longue meat.Make soup and gather except cold and heat, eliminating impediment.Survivor is especially good." heat clearing away, promote the production of body fluid, moisturize, laxation, removing blood stasis with potent drugs, tissue regeneration promoting, pain relieving, regulating menstruation, removing heat from blood, hemostasis are invigorated blood circulation.The Radix Rehmanniae is cold in nature, and function is heat clearing and blood cooling, enriching yin and nourishing kidney, promoting the production of body fluid to quench thirst, is usually used in the diseases such as treatment steaming bone and consumptive fever, throat pain, sputum mixed with blood.By by the Radix Rehmanniae with Fructus Amomi, wine, Pericarpium Citri Reticulatae for adjuvant, repeatedly steaming and shine to color blackening, quality softness is namely for Radix Rehmanniae Preparata, and has the LIUWEI DIHUANG WAN that Radix Rehmanniae Preparata makes, being exactly famous the kidney invigorating good medicine, clinic is also commonly used for the treatment that chronic nephritis, hypertension, neurasthenia, pulmonary tuberculosis etc. are sick.

Radix Scrophulariae: sweet, cold；GUIXIN, liver, kidney channel.Shennong's Herbal: " sweet in the mouth, cold.Cure mainly folding to fall, exhausted muscle, damaging the spleen and stomach, by arthralgia due to stagnation of blood, fill out bone marrow, longue meat.Make soup and gather except cold and heat, eliminating impediment.Survivor is especially good." heat clearing away, promote the production of body fluid, moisturize, laxation, removing blood stasis with potent drugs, tissue regeneration promoting, pain relieving, regulating menstruation, removing heat from blood, hemostasis are invigorated blood circulation.The Radix Rehmanniae is cold in nature, and function is heat clearing and blood cooling, enriching yin and nourishing kidney, promoting the production of body fluid to quench thirst, is usually used in the diseases such as treatment steaming bone and consumptive fever, throat pain, sputum mixed with blood.By by the Radix Rehmanniae with Fructus Amomi, wine, Pericarpium Citri Reticulatae for adjuvant, repeatedly steaming and shine to color blackening, quality softness is namely for Radix Rehmanniae Preparata, and has the LIUWEI DIHUANG WAN that Radix Rehmanniae Preparata makes, being exactly famous the kidney invigorating good medicine, clinic is also commonly used for the treatment that chronic nephritis, hypertension, neurasthenia, pulmonary tuberculosis etc. are sick.

Cornu Bubali: bitter salty, cold.Enter the heart, liver, spleen, stomach four warp." Luchuan book on Chinese herbal medicine ": " removing pathogenic heat from blood and toxic substance from the body, only nosebleed.Control calentura stupor, fiber crops pox macule, spit blood, epistaxis, heat in blood, dark coloured urine." heat clearing away, removing heat from blood, removing toxic substances.Control calentura headache, high fever coma, macule, tell nosebleed, infantile convulsion, sore throat pharyngeal swelling.Isolated Toad Heart and extrasomatic rabbit heart are all had potentiation by the aqueous solution (hereinafter referred to as extract) of Cornu Bovis seu Bubali decoct or ether extract, and can so as to stop at systole, this kind of cardiotonic is not caused by the inorganic salt contained by Cornu Bovis seu Bubali, occurs cardiotonic too because of extract.Cornu Bubali has the effect substantially shortening the bleeding time, and has the effect of blood pressure lowering.Its LVFS is 14.5%.Cornu Bubali ether or 95% ethanol extract, all have obvious sedation to rat.

Lapis Micae Aureus: salty is flat；Enter liver, lung, stomach warp." book on Chinese herbal medicine question and answer ": " Lapis Micae Aureus, must forge with Sal Nitri, and property begins to send out, and is to fall expectorant, does not forge, and stone matter is not changed, and the property of medicine is not sent out, and poison does not dissipate again, therefore must with forging." Miao Xiyong: " and Lapis Micae Aureus reports property just violent in stone, body weight and drop, disappearing, all gather expectorant knot, and removing food stagnancy is stagnant, fall sputum, are really key medicine." pendant expectorant, help digestion, the therapeutic method to keep the adverse QI flowing downwards, suppressing the hyperactive liver.Control the pertinacious phlegm hypochondriac lump, dyspepsia lump in the abdomen, demented infantile convulsion, dyspnea with rapid respiration of coughing, sputum is stopped up.Lapis Micae Aureus matter heavily falls and drops, salty in the mouth softening the hard mass, the kind disease controlling pertinacious phlegm glue admittedly, often joins Lignum Aquilariae Resinatum, Radix Scutellariae, the equivalent use of Radix Et Rhizoma Rhei.Control heat-phlegm to be jammed the convulsion with spasms caused, to forge Lapis Micae Aureus for end, be taken after mixing with liquid with Herba Menthae juice and whitish honey.If accumulation of phlegm is shied, constipation person, available Mengshi Guntan Wan is to calm the frightened by expectorant pathogenic fire reducing；Clinical in control insane and schizophrenia, to controlling outbreak and to slow down mania shape effective.

Pheretima: heat clearing away, spasmolytic, diuresis, removing toxic substances.For diseases such as calentura mania and irritation, infantile convulsion, cough with asthma, headache conjunctival congestion, laryngopharynx swelling and pain, urinary obstruction, Fengshi Guanjie pain, hemiplegia Pheretima dishes.External is coated with the disease such as erysipelas, dermatitis rhus.Lumbar injection earthworm injection 10g/kg in advance, surveys the pre-always cerebral infarction that artery ligation causes and has certain preventive effect, can alleviate the symptom of cerebral infarction mongolian gerbils one；Mice only gavages Pheretima extract l1mg/ every day, and continuous 58d, to the euphorbia egg decoctum transplanted.Having obvious inhibitory action, not only tumor body significantly reduces, and can extend the life cycle of mice.

Radix Polygoni Multiflori Preparata: bitter, sweet, puckery, temperature.Return liver, the heart, kidney channel.Function cures mainly: removing toxic substances, eliminating carbuncle, loosening bowel to relieve constipation.For scrofula carbuncle sore, rubella pruritus, dryness of the intestine constipation；Hyperlipidemia.

Flos Rosae Rugosae: warm in nature, sweet and slightly bitter taste, return liver spleen channel.Supplementary Amplifications of the Compendium of Materia Medica: " and blood, promoting the circulation of blood, regulate the flow of vital energy.Control migratory arthralgia." " book on Chinese herbal medicine is new again ": " the strongly fragrant gas of soothing liver-QI gallbladder, spleen invigorating pathogenic fire reducing.Controlling cold type of pain in abdomen, gastral cavilty is long-pending cold, and holding concurrently can removing blood stasis." promoting the circulation of QI, promoting the circulation of blood, control migratory arthralgia, dissipate tired pain relieving.Flos Rosae Rugosae and Herb have convergence, can be used for woman in menstrual period too much, and leucorrhea with red and white discharge and enteritis, dysentery, the red half of intestinal are hemorrhage.Regulate the flow of vital energy resolving depression and blood dissipating blood stasis.Cure mainly stomachache due to hyperactive liver-QI attacking the stomach, new lingering pathogenic wind numbness, spitting of blood of spitting blood, menoxenia, leucorrhea with red and white discharge, dysentery, acute mastitis, toxic swelling.Containing 300 various chemical components in Flos Rosae Rugosae, such as the alcohol of fragrance, aldehyde, fatty acid, phenol and the oil containing essence and fat, often food Flos Rosae Rugosae goods are waken up stomach with easing the affected liver, have a respite and invigorate blood circulation, looks improving and the skin nourishing, makes us refreshing refreshing.

FLOS MUME: sour and astringent, flat.Return liver, stomach, lung meridian.Supplementary Amplifications of the Compendium of Materia Medica: " " all sorts of flowers mirror ": powder for improving appetite is evil, food of cooking congee, helps the gas of clear sun to rise, and distillation point tea, promoting the production of body fluid to quench thirst, expelling summer-heat is washed tired." soothing liver-QI, stomach function regulating, reduces phlegm.Control globus hystericus, stomachache due to hyperactive liver-QI attacking the stomach, inappetence, dizziness, scrofula.Stomachache due to hyperactive liver-QI attacking the stomach.This product fragrance circulation of qi promoting enters liver stomach, can dispersing the stagnated live-QI to relieve the stagnation of QI, be amusing, regulate the flow of vital energy and in.

Nidus Vespae: sweet is flat.Return stomach warp.Function cures mainly: dispel the wind, merit poison, parasite killing, pain relieving.For toothache due to dental caries, sore swollen toxin, acute mastitis, scrofula, skin stubborn dermatitis, fungal infection of hand and foot.

Radix Ranunculi Ternati: sweet, pungent, tepor.Return liver, lung meridian.Dissipating phlegm and resolving masses, removing toxic substances and promoting subsidence of swelling.Cure mainly scrofula sucutaneous nodule, furuncle, worm venom, migraine, malaria, toothache.Pulmonary tuberculosis, tuberculous lymphadenitis, lymphadenitis, pharyngolaryngitis.For the mechanism of Radix Ranunculi Ternati anti-tubercle bacillus, Zhan Li etc. adopts reverse transcriptional PCR sxemiquantitative (QC-RT-PCR) method and PCR method, and Radix Ranunculi Ternati effective ingredient Seynuns Kugelann lactone (Tern) has carried out the research of anti-tubercle bacillus molecular immunology mechanism.

Bombyx Batryticatus: salty, pungent is flat；Return liver, lung, stomach warp.Shennong's Herbal: " main pediatric epilepsy scared, night cry, go three worms, goes out black, and it is good to make us complexion, and man's the moon infections is sick." Compendium of Material Medica: " and dissipating wind-phlegm tuberculosis, scrofula, wind syndrome of head, wind worm toothache, skin wind skin ulcer, erysipelas is had an itch ... all incised wounds, furuncle swells wind hemorrhoid." mice, rabbit all have hypnosis, anticonvulsant action by Bombyx Batryticatus alcohol water-leach liquor；Its extracting solution in vivo, outer all have stronger anticoagulation；Bombyx Batryticatus powder has good hypoglycemic activity；In vitro tests, has slight bacteriostasis to staphylococcus aureus, bacillus pyocyaneus, the external breathing suppressing human hepatoma cell of its alcohol extract, can be used for the treatment of rectum tumor type polyp.

Succus Bambusae: sweetness and bitterness, cold；Enter the heart, stomach warp.Essentials of Matea Medica: " pathogenic wind expelling pathogenic fire reducing, moisturizes row expectorant, and nourish blood tonifying YIN, profit key tomorrow.Controlling apoplexy locked mouth, the big heat of expectorant fan, puerperal tetanus is demented, and unhappiness is quenched one's thirst, spontaneous sweating due to deficientcy of blood." " book on Chinese herbal medicine is new again ": " clearing away heart-fire, drops liver-fire, reduces phlegm and quench the thirst, and toothache, bright eyes are controlled in antipyretic relieving restlessness." fire of the lung stomach that clears away heart-fire has eliminating phlegm to moisturize, the effect of arresting convulsion.Being mainly used in controlling middle wind-phlegm fan, lung-heat expectorant is stopped up, infantile convulsion, epilepsy, high fever excessive thirst, restlessness during pregnancy, tetanus.

Concretio Silicea Bambusae: sweet, cold；Enter the heart, liver, lung meridian." Japan hanako materia medica ": " control middle wind-phlegm to stop up, acute aphasia in silence, convulsive seizure induced by terror in children and epilepsy expectorant." " Kaibao Bencao ": " main infantile convulsion sky hangs, relieving palpitation improving eyesight, goes all wind heat, treats incised wound hemostasis, nourishes the five internal organs." function clear heat and eliminate phlegm, the cool heart is calmed the frightened.Curing mainly calentura coma delirium, middle wind-phlegm fan in silence, twitch, epilepsy by infantile convulsion.Phlegm-heat cough.Fungus Zhuhuang water decoction extract 2-3.1g/kg subcutaneous injection, has good analgesic activity to mice acetic acid zest pain.Hepatitis, through pharmacology preliminary test, is had certain curative effect by Fungus Zhuhuang polysaccharide SB1 and SB2, can dramatically prolongation blood plasma recalcification time, and in blood coagulation tests, this medicine can extend clotting time, it is possible to relevant with recalcification time prolongation.

Radix Platycodonis: bitter in the mouth, pungent, property is put down.Return lung meridian.There is lung qi dispersing, eliminate the phlegm, sore-throat relieving, evacuation of pus, profit the five internal organs, effect of filling blood, mending five kinds of over strain, foster the spirit of nobility.Cure mainly cough with copious phlegm, laryngopharynx swelling and pain, lung abscess vomiting pus, fullness in the chest and hypochondriac pain, dysentery stomachache, aphtha of the mouth and tongue, conjunctival congestion and swelling pain, uroschesis.For cough with copious phlegm, uncomfortable in chest not smooth, pharyngalgia, hoarseness, lung abscess vomiting pus, skin infection difficulty in discharging of pus." herbal classic " is said: " main chest and hypochondrium such as lancination, abdominal distention, borborygmus are faint, gas of throbbing with fear in terror "." Japan hanako materia medica " is said: " all gas lower, only cramp caused by acute vomiting and diarrhea, trusted subordinate's distending pain, mend five kinds of over strain, foster the spirit of nobility, and evil removing wards off temperature, qi-restoratives expectorant, broken lump in the abdomen, evacuation of pus of nourishing blood, and mends internal hemorrhage due to trauma and sore throat ".Modern pharmacological research shows, Radix Platycodonis has and eliminates the phlegm and antitussive effect；Hypoglycemic activity；Suppress gastric secretion and antiulcer action；Antiinflammatory action；Calmness, analgesia and refrigeration function.

Bulbus Lilii: Bulbus Lilii is except containing protein 21.29%, fat 12.43%, reducing sugar 11.47%, starch 1.61%, and calcium, phosphorus, ferrum, every hectogram containing nutrients such as 1.443 milligrams of vitamin Bs, 21.2 milligrams of vitamin Cs outside, possibly together with the nutritional labeling that some are special, such as multiple alkaloids such as colchicine.These composition comprehensive functions, in human body, not only have the merit of good nutritious tonifying, but also multiple Seasonal diseases that is dry in autumn and that cause are had certain preventive and therapeutic effect.The traditional Chinese medical science being said, fresh Bulbus Lilii has tranquilizing by nourishing the heart, effect of nourishing the lung to arrest cough, weakling after being ill is highly profitable.

Radix Asparagi: cold in nature, sweet and slightly bitter taste；Enter liver, lung, kidney channel." property of medicine opinion ": " main lung qi cough with dyspnea, pants short anxious, heat extraction, and logical kidney qi is treated the raw carbuncle vomiting pus of consumptive lung disease, controlled scabies humida, only quench one's thirst, apoplexy of reducing phlegm and internal heat, and should take for a long time." " Japan hanako materia medica ": " relieving palpitation, moistening five ZANG-organs, benefit skin, improving healthy complexion, mend five kinds of strain and seven kinds of impairment, control lung qi and cough, expectorant, migratory arthralgia pyretic toxicity, urticaria, unhappy haematemesis." to general benign breast tumor, especially breast lobule hyperplasia, no matter Tumor size, prove effective rapidly, great majority can obtain healing.Have and calm the nerves, nourish heart, lung moistening, tonification, nourishing kidney, the curative effect such as blood pressure lowering and loosening bowel to relieve constipation.Anthrax bacillus, A type and beta hemolytic streptococcus, diphtheria corynebacterium, diphtheroid, Diplococcus pneumoniae, staphylococcus aureus, Staphylococcus citreus, Staphylococcus albus and bacillus subtilis are all had bacteriostasis in various degree by decoct in vitro tests.

Rhizoma Polygonati Odorati: sweet in the mouth, property is put down；Attach to the lung and stomach meridians." property of medicine opinion ": " disease cold and heat time main, interior tonifying for the deficiency, remove asthenia exopathogenic heat, headache uneasiness, add and with good." " Japan hanako materia medica ": " relieving restlessness is vexed, quenches the thirst, and moistens cardiopulmonary, mends five kinds of strain and seven kinds of impairment, deficient, and waist foot pain pain, sky row is fanatical." Compendium of Material Medica: " main air temperature spontaneous perspiration is scorching hot, and malaria with general debility cold and heat, taste void is weary, man's frequent micturition, and consumption of essence, all are deficient." Rhizoma Polygonati Odorati sweet in the mouth greasiness, matter is soft and moistens, and is the good medicine of YIN nourishing and the production of body fluid promoting simply.. the steroid glycoside that Rhizoma Polygonati Odorati contains, the effect of cardiac muscle is similar with Herba Convallariae preparation.Isolated frog heart is had cardiotonic by Rhizoma Polygonati Odorati glycocide, and the effect of Rhizoma Polygonati Odorati decoct is similar with Rhizoma Polygonati Odorati glycocide.Rhizoma Polygonati Odorati extractum lumbar injection, can strengthen burned mice Peritoneal macrophages Phagocytosis, improves Hemolysin level, improves the splenocyte breeder reaction to ConA.These product have promotion laboratory animal antibody tormation, improve phagocytic percentage and the phagocytic index of macrophage, promote interferon synthesis, it is suppressed that growth of bacillus tubercle, blood sugar lowering, blood fat reducing, alleviates atherosclerotic plaque and is formed, make peripheral blood vessel and coronary dilation, extend hypoxia endurance time, heart tonifying, antioxidation, the anti-ageing effect of waiting for a long time.Also has similar adrenocortical hormone sample effect.

Rhizoma Polygonati: sweet in the mouth, property is put down, and enters lung, spleen, kidney channel, there is enriching qi and yin, spleen invigorating lung moistening, effect of enriching kidney essence, for taste deficiency of qi and yin, lack of appetite is unable, lung-dryness syndrome due to deficiency of YIN, the few expectorant of dry cough, dry cough expectorant is few, polydipsia of quenching one's thirst, weakness of the spleen and stomach, deficiency of spleen-QI or deficiency of spleen-YIN, quenching one's thirst of yin asthenia generating intrinsic heat, deficiency of kidney essence, impotence and seminal emission, dizziness and tinnitus, blurred vision dim eyesight etc. are demonstrate,proved.In vitro tests shows, Rhizoma Polygonati water proposes liquid (1:320) has inhibitory action to Bacillus typhi, staphylococcus aureus, acid-fast bacilli, and common causative fungus is had inhibitory action in various degree by 2% Rhizoma Polygonati in sabouraud culture medium.Rabbit gavage Rhizoma Polygonati extractum, its blood sugar content increases gradually, then reduces.The blood glucose that epinephrine is caused by Rhizoma Polygonati extractum is too high in notable inhibitory action.

Fructus Lycii: sweet is flat.Enter liver, kidney, lung meridian." Treatise on Dietetic Therapy ": " hard muscle is resistance to always, except wind, tonification muscles and bones, energy benefit people, removes asthenia." control hepatic and renal YIN deficiency, replenishing vital essence to improve eyesight.For asthenia damage of essence, soreness of waist and knee joint, vertigo and tinnitus, impotence and seminal emission, interior-heat is quenched one's thirst, blood deficiency and yellow complexion, and blurred vision is failed to understand.Lycium barbarum polysaccharide has promotion immunity, defying age, antitumor, scavenging free radicals, resisting fatigue, radioprotective, protects the liver, reproductive function protection and improvement etc. act on.Carotene is the main active of wolfberry pigment, has antioxidation and the synthesis important physiological function such as precursor as vitamin A.Mouse gavaging Fructus Lycii water extract or intramuscular injection alcohol extract and lycium barbarum polysaccharide, the phagocytic function of the macrophage that is improved, strengthen the effect of serum lysozyme, improve the titer of anti-sheep red blood cell (SRBC) antibody in serum.

Fructus Ligustri Lucidi: sweet in the mouth, hardship, is slightly cold, and enters liver, kidney channel, has strong liver kidney tonifying, the effect of clearing away heat to improve acuity of vision, is mainly used in treatment hepatic and renal YIN deficiency, the symptoms such as the head loses foster giddy tinnitus, yin asthenia generating intrinsic heat.This product energy tonifying liver kidney yin, but the efficacy of a drug is gentle, must slowly take effect.Controlling poor vision, often join Radix Rehmanniae Preparata, Semen Cuscutae, Fructus Lycii is equal to use, controls early whitening of beard and hair, often joins Herba Ecliptae, and Fructus Mori are equal to use, control fever due to yin deficiency, often joins Cortex Lycii, and Radix Rehmanniae is equivalent to be used.Compendium of Material Medica is recorded: " it is verdant that winter insulted by this wood, has the behaviour that chastity is kept, therefore with Fructus Ligustri Lucidi shape it ... to put wax insect time near, therefore be commonly called as wax tree." Fructus Ligustri Lucidi can promote leukocyte, strengthens effect of immunologic function, staphylococcus aureus, dysentery bacterium are had stronger inhibitory action.Modern medicine study proves, Fructus Ligustri Lucidi includes ursolic acid, mannitol, glucose, fat wet goods, has heart tonifying, diuresis and hepatoprotective effect, the leukopenia quantity caused because of chemotherapy can be made to raise, and staphylococcus aureus, escherichia coli are had inhibitory action.

Fructus Mori: bitter in the mouth, sweet, cold in nature；Return lung, Liver Channel.Supplement to the Herbal: " main abdominal pain due to acute vomiting and diarrhea is told down, and the eleventh month of the lunar calendar takes it with dry dense the boiling of person.Smooth file, takes such as red sugar, removes old wind and stagnated blood in big still." " Japan hanako materia medica ": " profit the five internal organs, get round by bribery, the therapeutic method to keep the adverse QI flowing downwards, decoction；Except wind pain is perspired, and flutter damage blood stasis, and after steaming；Scolopendra stings snakeworm, and salt applies." Folium Mori energy dispelling wind and heat pathogens, heat clearing away of inducing sweat, YIN nourishing and the production of body fluid promoting；Fructus Mori energy nourishing YIN and benefiting blood, qi-restoratives is moisturized；Cortex Mori energy eliminating pathogen from the lung for relieving asthma, inducing diuresis to remove edema；Ramulus Mori energy dredge the meridian passage, eliminating impediment pain relieving；And the ash that mulberry burns till is Pulvis Lignum Mori, can be used for treatment conjunctival congestion and swelling pain, optic atrohic blindness, body face edema, sitting and lying must not, the disease such as vitiligo, seborrheic dermatitis of the scalp, leprosy.Containing trypsininhibitory substance in Fructus Mori, cause the digestive enzyme in intestinal can not destroy C type and produce bacillus capsulatus B toxin, and causing bleeding property enteritis.Fructus Mori fatty acids, digestive tract can be produced irritation by excessive eating.

Carapax Et Plastrum Testudinis: salty, sweet, is slightly cold；Return liver, kidney, heart channel.Compendium of Material Medica: " reinforcing the heart, the kidney invigorating, enriching blood, all with yin nourishing also ... see Carapax Et Plastrum Testudinis and led all diseases, all genus deficiency of YIN blood is weak." nourishing YIN for suppressing the hyperactive YANG, kidney tonifying bone strengthening, reinforcing the heart of nourishing blood.For deficiency of YIN hectic fever, hectic fever due to YIN-deficiency night sweat, having a dizzy spell, stirring-up of pathogenic wind in the interior resulting from deficiency, muscles and bones flaccidity is soft, has a guilty conscience forgetful.During decoct high concentration, Isolated Rat Uterus is had certain contraction；Bacillus tuberculosis there is inhibitory action；Rat hormonal system is had impact in 6 days by the continuous gavage of Carapax Et Plastrum Testudinis decoct.Carapax Et Plastrum Testudinis can improve animal " deficiency of YIN " and demonstrate,prove pathology animal functional status, so as to recover normal；Immunologic function can be strengthened；There is the effect of two-ways regulation DNA synthetic ratio；In vitro and Uterus in vivo all there is excitation；Have antipyretic, enrich blood, sedation；Still there is anticoagulation, increase coronary flow and improve the effects such as hypoxia-bearing capability；Colla Plastri Testudinis has certain effect promoting leukocyte count.

Folium Artemisiae Argyi: pungent, bitter, temperature.Return liver,spleen,kidney warp.Function cures mainly: dispersing cold for relieving pain, warming the meridian for stopping bleeding.For few abdomen cold type of pain, coldness and unbalance in meridians, cold womb is infertile, spit blood, epistaxis, metrorrhagia through many, gestation hemorrhage；External treatment skin pruritus.Vinegar Chinese mugwort charcoal warming the meridian for stopping bleeding.Hemorrhage for deficient cold type.

Radix Trichosanthis: hardship sweet, micro-, is slightly cold.Attach to the lung and stomach meridians.Function cures mainly: clearing away heat and promoting production of body fluid, detumescence and apocenosis.For calentura excessive thirst, lung-heat type cough, interior-heat is quenched one's thirst, sore swollen toxin.

Semen Ziziphi Spinosae: sweet, sour, property is put down.GUIXIN warp, spleen channel, Liver Channel, gallbladder meridian.Shennong's Herbal: " invigorating middle warmer the liver benefiting, hard muscles and bones help cloudy gas, and all the merit of Semen Ziziphi Spinosae is also." " herbal classic ": " main trusted subordinate's cold and heat, pathogens agglomerating gas gathers, painful limbs, arthralgia chiefly caused by damp pathogen." " not Lu ": " main vexatious insomnia, umbilicus is pain up and down, and blood turns chronic diarrhea, sweating due to debility excessive thirst, invigorating middle warmer, the liver benefiting gas, hard muscles and bones, helps cloudy gas, makes us fertile strong." " property of medicine opinion ": " main muscles and bones wind is fried end and is taken it as soup.Function " nourishing the liver, mind calming, calm the nerves, arresting sweating.There are calmness, hypnosis, analgesia, anticonvulsant action；There is certain hypotensive effect；Uterus there is excitation.For deficiency of YIN-blood, severe palpitation, insomnia forgetfulness；Body void hyperhidrosis.Semen Ziziphi Spinosae decoct is oral to rat or lumbar injection all behaves with composure and somnolence, no matter daytime or night, and Semen Ziziphi Spinosae all can show above-mentioned effect.

Semen Platycladi: sweet is flat.GUIXIN, kidney, large intestine channel.Shennong's Herbal: " cypress is real, and sweet in the mouth is put down, and main palpitation with fear, settling five organs, QI invigorating, except rheumatism numbness, clothes of a specified duration make us moist, beauty, normal hearing and eyesight." Compendium of Material Medica: " nourish heart gas, and profit kidney is dry, and peace soul determines soul, and Fructus Alpiniae Oxyphyllae is allayed excitement." " Semen Platycladi is flat and cold not dry, sweet in the mouth and mend, pungent and can moisten, its gas delicate fragrance, the saturating heart kidney of energy, strengthening the spleen stomach." tranquilizing by nourishing the heart, loosening bowel to relieve constipation.For diseases such as restlessness of asrhenia type and insomnia, severe palpitation, dryness of the intestine constipation.Semen Platycladi folk prescription injection can make the S sleep sound sleep phase of cat be obviously prolonged, and has the effect of regaining one's strength significantly.

Rhizoma et radix valerianae: pungent, sweet, warm；GUIXIN, Liver Channel." Traditional Chinese Medicine in Sichuan will ": " controlling cranial nerve and the heart, stomach weak, chronic forms is not normal and urine collapses." controlling irritability, stomach is weak, lumbago, menoxenia, traumatic injury.Apply its effect calmed the nerves to can be used to treat the disease such as malaise, cardiopalmus dreaminess, can with compatibilities such as Semen Ziziphi Spinosae, Cortex Albiziae, Caulis Polygoni Multiflori；Another and Radix Salviae Miltiorrhizae, Herba Leonuri, Herba Lycopi, the same use of Flos Carthami, can be used to treat the disease of abdominal pain in menstruation, soreness of the waist and knees, bone fracture and injury.Central nervous system is had quelling to act on by Rhizoma et radix valerianae, can stabilize nerve when excited, then can help when fatigue to refresh.Rhizoma et radix valerianae epoxy three ester contained by Rhizoma et radix valerianae root can help to alleviate spasm and pain, contributes to relaxing neuropathic dyspepsia, stomach spasm or enteritis.Total alkaloids in Rhizoma et radix valerianae has antibacterial action, especially can resist the infection that gram-positive bacterium is caused.The pink flowers Rhizoma et radix valerianae of Rhizoma et radix valerianae can relieving insomnia, sleep disorder, flurried, anxiety neurosis and other disorder, also can relax one's muscles simultaneously, make environment oil recover stable state.

Radix Polygalae: bitter, pungent, tepor；GUIXIN, kidney, lung meridian.Shennong's Herbal: " main cough with dyspnea damaging the spleen and stomach, tonifying for the deficiency, evil removing gas, profit nine orifices, Fructus Alpiniae Oxyphyllae is intelligent, normal hearing and eyesight, does not forget, strong will times power." " Japan hanako materia medica ": " the frightened black mole of main diaphragm gas, longue meat help muscles and bones, married woman's blood to keep silent aphonia, convulsive seizure induced by terror in children." Fructus Alpiniae Oxyphyllae of calming the nerves, eliminate the phlegm, insomnia and dreamful sleep of subsiding a swelling, forgetful palpitation with fear, staring spells.Insomnia and dreamful sleep, severe palpitation, forgetful.Epilepsy mania and irritation, spasm is twitched, skin sore.Modern pharmacological research shows, Radix Polygalae xylem haemolysis relatively skin zone is low.

Rhizoma Acori Graminei: nature and flavor are pungent, bitter, temperature.GUIXIN, stomach warp.Can removing dampness whet the appetite, eliminating phlegm of having one's ideas straightened out, refreshment Fructus Alpiniae Oxyphyllae., keep silent a mouthful dysentery not hungry for gastral cavity painful abdominal mass, coma epilepsy, forgetful deafness.Regulate the flow of vital energy, invigorate blood circulation, dissipate wind, dry.Controlling epilepsy, syncope due to accumulation of phlegm, calentura coma, forgetful, deafness with qi stagnation, ambition is unhappy, stomachache, stomachache, anemofrigid-damp arthralgia, swollen ulcer drug, traumatic injury." not Lu " records it: " main deafness, ulcerative carbuncle, warming intestines and stomach, only normal urination, extremity arthralgia chiefly caused by damp pathogen, must not bend and stretch, children's's pyrexial malaria, and body accumulated heat is not understood, and can make bath soup.Audition improvement order, benefit intelligence." secretion of Rhizoma Acori Graminei decoct energy for oral administration facilitating digestion liquid and prevention gastrointestinal abnormal fermentation, and have the effect alleviating intestinal tube smooth muscle spasm.In Rhizoma Acori Graminei containing asaricin can resist the excitation of the intestine in vitro that barium chloride causes.

In above-mentioned external used medicine, the pharmacology of each raw medicinal material is as follows:

Radix Angelicae Sinensis: sweet, acrid, warm.Return liver, the heart, spleen channel.Replenishing and activating blood, menstruction regulating and pain relieving, loosening bowel to relieve constipation.For blood deficiency and yellow complexion, dizziness cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores.Radix Angelicae Sinensis (processed with wine) promoting blood circulation to restore menstrual flow.For amenorrhea dysmenorrhea, rheumatic arthralgia, injury from falling down.

Pericarpium Zanthoxyli: pungent, temperature.Return spleen, stomach, kidney channel.Function cures mainly: warming middle-JIAO to relieve pain, killing parasites for relieving itching.For coldness and pain in the epigastrium, vomiting is had loose bowels, abdominal pain due to worm stagnation, ascariasis；External treatment eczema pruritus.

Radix Polygalae: bitter, pungent, tepor；GUIXIN, kidney, lung meridian.Shennong's Herbal: " main cough with dyspnea damaging the spleen and stomach, tonifying for the deficiency, evil removing gas, profit nine orifices, Fructus Alpiniae Oxyphyllae is intelligent, normal hearing and eyesight, does not forget, strong will times power." " Japan hanako materia medica ": " the frightened black mole of main diaphragm gas, longue meat help muscles and bones, married woman's blood to keep silent aphonia, convulsive seizure induced by terror in children." Fructus Alpiniae Oxyphyllae of calming the nerves, eliminate the phlegm, insomnia and dreamful sleep of subsiding a swelling, forgetful palpitation with fear, staring spells.Insomnia and dreamful sleep, severe palpitation, forgetful.Epilepsy mania and irritation, spasm is twitched, skin sore.Modern pharmacological research shows, Radix Polygalae xylem haemolysis relatively skin zone is low.

Cortex Cinnamomi: extremely hot in nature, acrid in the mouth, sweet.Return kidney, spleen, the heart, Liver Channel.Mend fire supporing yang, let the fire back to its origin, dispersing cold for relieving pain, promoting blood circulation to restore menstrual flow.Warming the spleen and stomach, removing accumulated cold, promoting blood circulation.Controlling decline of the fire from the gate of life, cold extremities faint pulse, YANG-depletion is collapsed, and stomachache is had loose bowels, colic of cold type renal mass, chills and pain of the waist and kness, amenorrhea lump in the abdomen, carbuncle of yin nature, multiple abscess, and empty sun is floating more, heat in the upper and cold in the lower.For sexual impotence, cold womb, trusted subordinate's cold type of pain, deficiency and coldness vomiting and diarrhoea, amenorrhea, dysmenorrhea, warming the meridian and promoting blood circulation." Bencao Jingshu " is recorded: Ramulus Cinnamomi, Cortex Cinnamomi, Cortex Cinnamomi, husband's five tastes sweet and pungent flavors inducing perspiration and pertaining to yang, four gas heat are also positive；The pure sun of taste, therefore can dispersing wind and cold；Outside interior filling, therefore can real table；Pungent to dissipate it, heat with row, sweet with and it, therefore blood blood can be entered, moisten kidney dry.Its main benefitting liver and lung gas, headache, perspiration, only tired, only saliva, cough, nose, reason dredge deficiency, exterior deficiency spontaneous perspiration, migratory arthralgia joint spasm and pain person, the institute of Ramulus Cinnamomi controls also.With its disease all exterior deficiency do not appoint wind and cold, caused by cold-evil visitor, thus in knowing it, with its can reality table eliminating evil also.Its main cold disease of trusted subordinate's cold and heat, cramp caused by acute vomiting and diarrhea, lumbago, induced abortion, warming middle-JIAO, hard muscles and bones, promoting blood circulation, a surname lead hundred medicines without being feared, mended again that the part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels is not enough, control chronic diseases, ooze let out, quench the thirst, only wind and cold, autumn and winter bottom stomachache affection of cold in Rong Wei, mend the gate of vitality, boosting source of fire for eliminating abundance of yin person, the institute of Cortex Cinnamomi controls also.Gas is thin to lightly float, and floats and reaches table, thus Ramulus Cinnamomi control that evil visitor's table divides for disease.Rich sweet pungent big heat, and in lower walking, therefore Cortex Cinnamomi, Cortex Cinnamomi control the kidney-yang deficiency of the gate of vitality, yang deficiency is cold move in, and all interior deficiency YIN-cold, in cold-evil visitor is disease.Cover with Cortex Cinnamomi, Cortex Cinnamomi sweet pungent and hot greatly, so Yiyang；Sweet enter blood system, pungent energy horizontal walk, heat is then passed through, and closes this three, therefore benefaction blood.

Amylum Nelumbinis Rhizomatis: benefit blood, hemostasis, in tune, appetizing.Control deficient losing blood, dysentery lack of appetite.1. " explaining abstruseness of the canon of materia medica ": " calm the nerves, appetizing." 2. " herbal classic is met former ": " controls deficient losing blood, vomiting and diarrhea hematochezia.Dysentery locked mouth can not be eaten again, be taken in small doses at short intervals then knot excrement under, gastric qi from opening, just can be taken food." 3. " detailed outline is picked up any lost article from the road ": " whets the appetite in adjusting, and mends marrow benefit blood, ventilation point, clear exterior heat, often eats raw wisdom of calming the nerves, and expelling summer-heat promotes the production of body fluid, and help digestion antidiarrheal."

The Rhizoma Atractylodis Macrocephalae: for the dry rhizome of the feverfew Rhizoma Atractylodis Macrocephalae.Return spleen, stomach warp, bitter in the mouth, sweet and warm in nature.Function invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive." medicine origin " records the Rhizoma Atractylodis Macrocephalae " dehumidifying benefit is dry, and middle QI invigorating, warming middle-JIAO, goes in taste wet, except gastric heat, strong taste, enter diet, quench the thirst, antiabortive "；Shennong's Herbal records the Rhizoma Atractylodis Macrocephalae " the sweet temperature of abnormal smells from the patient, nontoxic, control anemofrigid-damp arthralgia, dead flesh, convulsion subcutaneous ulcer, hidroschesis, heat extraction, help digestion "；" Yaoxing Fu " record the Rhizoma Atractylodis Macrocephalae " sweet in the mouth, temperature, nontoxic.Can rising and can drop, sun is also.It is with having four: dredging water passages, has the merit of dehumidifying；Strong taste, have the effect of feed, and assistant Radix Scutellariae has antiabortive energy, and monarch's Fructus Aurantii Immaturus has the wonderful of the painful abdominal mass that disappears ".

Aloe: under rushing down；Liver heat removing；Parasite killing.Main constipation with heat retention；Liver-fire is had a headache；Conjunctival congestion infantile convulsion；Abdominal pain due to worm stagnation；Scabies；Hemorrhoid complicated by anal fistula；Solution Fructus Crotonis poison.For constipation, infantile malnutrition, infantile convulsion；External treatment exudative dermatitis.1. " property of medicine opinion ": kill children's infantile malnutrition ascarid.Head boil of malnutrition infant is killed in main nasal insufflation, except rhinocnesmus.2. " Haiyao Bencao, Oversea Materia Medica ": all infantile malnutrition with fever of main children's.3. " Kaibao Bencao ": main hot blast is unhappy, steam between chest and diaphragm, improving eyesight relieving palpitation, children epilepsy infantile convulsion, treat five kinds of child malnutrition, kill three worms and hemorrhoid disease skin ulcer fistula.Solution Fructus Crotonis poison.4. " Bencao Tujing ": control pruritus due to damp pathogen, that scratches has yellow juice person；Control again tooth of hideing.5. " must joining book on Chinese herbal medicine ": dissipate scrofula, control infantile convulsion, diuretic is except swollen.6. " book on Chinese herbal medicine is new again ": treating the liver fire, town liver-wind, clear away heart-fire heat, and relaxing vexation is slaked thirst and help produce saliva, hearing-improing and eyesight improving, and the tooth that disappears swells, and solves fire-toxin.

The Radix Aucklandiae: promoting the circulation of QI to relieve pain；Intestinal stasis relieving in tune.Main born of the same parents coerce distension foot；Abdominal distention；Tell and have loose bowels；Weight after dysentery.For weighing after breast gastral cavity distending pain, dysentery, food stagnation does not disappear, anorexia.1. the distension and fullness in the abdomen of stagnation of QI in spleen and stomach or pain, belch, nausea and vomiting.2. the abdominal distention uncomfortable in chest of turbid damp obstructing in middle-JIAO, indigestion and loss of appetite loose stool.3. phlegm-damp stops up the cough and asthma of lung.4. pathogen, wards off poison epidemic disease temperature ghost, and Qiang Zhi, main pouring is revealed.Take not dream awake horrible nightmare for a long time.5. sterilization, kill ghost essence thing, pyrexial malaria diseases due to noxious agents produced by various parasites, the bad QI-insufficiency of gas, partially cold in flesh, the essence of priming.

nullIn described endo-medicine, the parts by weight of each raw medicinal material are: Mirabilitum crystallina 5-9 weight portion、Fructus Gardeniae 10-15 weight portion、Folium Bambusae 10-20 weight portion、Rhizoma Coptidis 15-25 weight portion、Rhizoma Bistortae 10-15 weight portion、Radix Rehmanniae 5-15 weight portion、Radix Scrophulariae 10-15 weight portion、Cornu Bubali 3-9 weight portion、Lapis Micae Aureus 3-10 weight portion、Pheretima 10-15 weight portion、Radix Polygoni Multiflori Preparata 10-20 weight portion、Flos Rosae Rugosae 15-25 weight portion、FLOS MUME 10-15 weight portion、Nidus Vespae 10-25 weight portion、Radix Ranunculi Ternati 5-10 weight portion、Bombyx Batryticatus 15-25 weight portion、Succus Bambusae 10-15 weight portion、Concretio Silicea Bambusae 5-15 weight portion、Radix Platycodonis 10-20 weight portion、Bulbus Lilii 15-25 weight portion、Radix Asparagi 10-20 weight portion、Rhizoma Polygonati Odorati 5-15 weight portion、Rhizoma Polygonati 10-15 weight portion、Fructus Lycii 15-25 weight portion、Fructus Ligustri Lucidi 10-17 weight portion、Fructus Mori 15-25 weight portion、Carapax Et Plastrum Testudinis 3-8 weight portion、Folium Artemisiae Argyi 10-15 weight portion、Radix Trichosanthis 5-10 weight portion、Semen Ziziphi Spinosae 10-25 weight portion、Semen Platycladi 15-25 weight portion、Rhizoma et radix valerianae 9-16 weight portion、Radix Polygalae 10-15 weight portion and Rhizoma Acori Graminei 5-12 weight portion；

In described medicine for external use thing, the parts by weight of each raw medicinal material are: Radix Angelicae Sinensis 10-20 weight portion, Pericarpium Zanthoxyli 5-10 weight portion, Radix Polygalae 5-12 weight portion, Cortex Cinnamomi 5-8 weight portion, Amylum Nelumbinis Rhizomatis 5-20 weight portion, Rhizoma Atractylodis Macrocephalae 5-9 weight portion, Aloe 10-20 weight portion and Radix Aucklandiae 5-12 weight portion.

nullIn described endo-medicine, the parts by weight of each raw medicinal material are preferably: Mirabilitum crystallina 7 weight portion、Fructus Gardeniae 12 weight portion、Folium Bambusae 15 weight portion、Rhizoma Coptidis 21 weight portion、Rhizoma Bistortae 12 weight portion、The Radix Rehmanniae 7 weight portion、Radix Scrophulariae 12 weight portion、Cornu Bubali 5 weight portion、Lapis Micae Aureus 7 weight portion、Pheretima 12 weight portion、Radix Polygoni Multiflori Preparata 15 weight portion、Flos Rosae Rugosae 22 weight portion、FLOS MUME 12 weight portion、Nidus Vespae 17 weight portion、Radix Ranunculi Ternati 7 weight portion、Bombyx Batryticatus 19 weight portion、Succus Bambusae 12 weight portion、Concretio Silicea Bambusae 11 weight portion、Radix Platycodonis 15 weight portion、Bulbus Lilii 21 weight portion、Radix Asparagi 15 weight portion、Rhizoma Polygonati Odorati 11 weight portion、Rhizoma Polygonati 12 weight portion、Fructus Lycii 21 weight portion、Fructus Ligustri Lucidi 14 weight portion、Fructus Mori 21 weight portion、Carapax Et Plastrum Testudinis 6 weight portion、Folium Artemisiae Argyi 13 weight portion、Radix Trichosanthis 6 weight portion、Semen Ziziphi Spinosae 22 weight portion、Semen Platycladi 21 weight portion、Rhizoma et radix valerianae 12 weight portion、Radix Polygalae 12 weight portion and Rhizoma Acori Graminei 7 weight portion；

In described medicine for external use thing, the parts by weight of each raw medicinal material are preferably: Radix Angelicae Sinensis 15 weight portion, Pericarpium Zanthoxyli 7 weight portion, Radix Polygalae 8 weight portion, Cortex Cinnamomi 6 weight portion, Amylum Nelumbinis Rhizomatis 12 weight portion, the Rhizoma Atractylodis Macrocephalae 7 weight portion, Aloe 15 weight portion and the Radix Aucklandiae 7 weight portion.

nullIn described endo-medicine, the parts by weight of each raw medicinal material can also be preferably: Mirabilitum crystallina 5 weight portion、Fructus Gardeniae 15 weight portion、Folium Bambusae 20 weight portion、Rhizoma Coptidis 25 weight portion、Rhizoma Bistortae 10 weight portion、The Radix Rehmanniae 5 weight portion、Radix Scrophulariae 10 weight portion、Cornu Bubali 3 weight portion、Lapis Micae Aureus 10 weight portion、Pheretima 10 weight portion、Radix Polygoni Multiflori Preparata 10 weight portion、Flos Rosae Rugosae 25 weight portion、FLOS MUME 15 weight portion、Nidus Vespae 25 weight portion、Radix Ranunculi Ternati 5 weight portion、Bombyx Batryticatus 25 weight portion、Succus Bambusae 10 weight portion、Concretio Silicea Bambusae 5 weight portion、Radix Platycodonis 10 weight portion、Bulbus Lilii 25 weight portion、Radix Asparagi 10 weight portion、Rhizoma Polygonati Odorati 15 weight portion、Rhizoma Polygonati 10 weight portion、Fructus Lycii 15 weight portion、Fructus Ligustri Lucidi 10 weight portion、Fructus Mori 15 weight portion、Carapax Et Plastrum Testudinis 3 weight portion、Folium Artemisiae Argyi 15 weight portion、Radix Trichosanthis 10 weight portion、Semen Ziziphi Spinosae 25 weight portion、Semen Platycladi 25 weight portion、Rhizoma et radix valerianae 16 weight portion、Radix Polygalae 10 weight portion and Rhizoma Acori Graminei 5 weight portion；

In described medicine for external use thing, the parts by weight of each raw medicinal material can also be preferably: Radix Angelicae Sinensis 20 weight portion, Pericarpium Zanthoxyli 10 weight portion, Radix Polygalae 5 weight portion, Cortex Cinnamomi 8 weight portion, Amylum Nelumbinis Rhizomatis 15 weight portion, the Rhizoma Atractylodis Macrocephalae 9 weight portion, Aloe 20 weight portion and the Radix Aucklandiae 12 weight portion.

When the dosage form of endo-medicine is oral solutions, its preparation method comprises the following steps:

The first step, Fructus Gardeniae, Folium Bambusae, Pheretima, Radix Polygoni Multiflori Preparata and Flos Rosae Rugosae are mixed, adding relative to mixture 3 times～5 times amount determining alcohol is the ethanol of 55%～65%, reflux, extract, 2～4 times, each 2 hours～3 hours, filters, filtrate merges, reclaiming ethanol, being concentrated into 70 DEG C of relative densities is the mastic of 1.30～1.32, standby；

Second step, is mixed in proportion surplus stock medical material, adds relative to mixture 3～5 times amount water, boils 2～4 hours, filters, and being concentrated into 70 DEG C of relative densities is the mastic of 1.27～1.29；

3rd step, the described mastic mixing first step, second step obtained, 55 DEG C～65 DEG C reduced vacuum dry, and get dry extract powder；

4th step, added ethanol in the described dried cream powder the 3rd step obtained, obtains containing alcohol mastic, and the alcohol content of described containing alcohol mastic is 65%～70%；Described containing alcohol mastic being sequentially carried out chilling treatment, precipitation process, filtration treatment, recovery Ethanol Treatment, obtains dealcoholysis mastic, wherein, the chilling treatment time is 30～40 hours；

5th step, will add cane sugar powder, activated carbon in described dealcoholysis mastic, be sequentially carried out heat treated, filtration treatment, dilution process, obtain semi-finished product；The weight ratio of described dealcoholysis mastic and described cane sugar powder is 1: 0.1～0.3；The weight ratio of described dealcoholysis mastic and described activated carbon is 1: 0.001～0.002；The time of described heat treated is 20～40 minutes, and temperature is 100 DEG C～110 DEG C；

6th step, the more described semi-finished product that the 5th step obtains are sequentially carried out filtration treatment, embedding process, sterilization treatment, obtain described Chinese medicine preparation oral liquid finished product.

When the dosage form of endo-medicine is tablet, its preparation method comprises the following steps:

The first step, is mixed in proportion described each raw medicinal material, adds the ethanol that determining alcohol is 85%～95% relative to mixture quality 2～4 times, is heated to reflux 1～3 hour, extracts, and filters and obtains the first extracting solution；Filter the medicinal residues obtained and add the ethanol that determining alcohol is 85%～95% relative to described medicinal residues quality 1～2 times, be heated to reflux 1～3 hour, extract, filter and obtain the second extracting solution；First extracting solution and the second extracting solution being merged, concentrating under reduced pressure removes alcohol solvent, dry, it is thus achieved that dry cream；

Second step, is placed in super micron mill by the dry cream that the first step obtains and pulverizes 1～2 hour, pulverizes, sieves, it is thus achieved that the micropowders of 300 order～400 orders；

3rd step, the micropowders that second step is obtained, add relative to the microcrystalline Cellulose of its quality 0.1～0.3 times, 0.05～0.15 times of lactose, the starch of 0.1～0.3 times, sieve, mix homogeneously, granulate, dry, add relative to 0.005～0.05 times of magnesium stearate of micropowders quality, granulate, tabletting, makes.

When the dosage form of external used medicine is navel patch, its preparation method comprises the following steps:

The first step, is mixed in proportion described each raw medicinal material, is ground into the powder of 40 order～60 orders, adds the ethanol that determining alcohol is 85～95% relative to mixture quality 2～4 times, is heated to reflux 1～3 hour, extracts, and filters and obtains the first extracting solution；Filter the medicinal residues obtained and add the ethanol that determining alcohol is 85～95% relative to described medicinal residues quality 1～2 times, be heated to reflux 1～3 hour, extract, filter and obtain the second extracting solution；First extracting solution and the second extracting solution being merged, concentrating under reduced pressure removes alcohol solvent, dry, it is thus achieved that dry cream, is ground into the powder of 100 order～200 orders；

Second step, dissolves stearic acid heating, and being maintained at temperature is 70 DEG C～80 DEG C, it is thus achieved that stearic acid liquid；It addition, potassium hydroxide, glycerol, ethyl hydroxybenzoate and distilled water to be pressed the part by weight mixing of 5:500:1:600, heating, maintain the temperature at 70 DEG C～80 DEG C, it is thus achieved that distilled water mixed liquor；Stearic acid liquid is slowly added in distilled water mixed liquor according to the part by weight of 1:100, stirs cooling, it is thus achieved that substrate simultaneously；

3rd step, the substrate obtained to second step adds the Chinese medicinal powder that the first step of equivalent obtains, and is constantly ground to uniformly, and heating obtains sticky paste, granulates, and after drying, obtains pill, coordinates medical proof fabric or special navel paster that pill is attached to umbilicus place.

Hereinafter adopting embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the process that realizes reaching technique effect can fully understand and implement according to this.

Embodiment 1 oral solutions

nullEmbodiments provide a kind of for treating the heart schizoid endo-medicine of kidney disorder type，Dosage form is oral solutions，In this medicine, the parts by weight of each raw medicinal material are: Mirabilitum crystallina 7 weight portion、Fructus Gardeniae 12 weight portion、Folium Bambusae 15 weight portion、Rhizoma Coptidis 21 weight portion、Rhizoma Bistortae 12 weight portion、The Radix Rehmanniae 7 weight portion、Radix Scrophulariae 12 weight portion、Cornu Bubali 5 weight portion、Lapis Micae Aureus 7 weight portion、Pheretima 12 weight portion、Radix Polygoni Multiflori Preparata 15 weight portion、Flos Rosae Rugosae 22 weight portion、FLOS MUME 12 weight portion、Nidus Vespae 17 weight portion、Radix Ranunculi Ternati 7 weight portion、Bombyx Batryticatus 19 weight portion、Succus Bambusae 12 weight portion、Concretio Silicea Bambusae 11 weight portion、Radix Platycodonis 15 weight portion、Bulbus Lilii 21 weight portion、Radix Asparagi 15 weight portion、Rhizoma Polygonati Odorati 11 weight portion、Rhizoma Polygonati 12 weight portion、Fructus Lycii 21 weight portion、Fructus Ligustri Lucidi 14 weight portion、Fructus Mori 21 weight portion、Carapax Et Plastrum Testudinis 6 weight portion、Folium Artemisiae Argyi 13 weight portion、Radix Trichosanthis 6 weight portion、Semen Ziziphi Spinosae 22 weight portion、Semen Platycladi 21 weight portion、Rhizoma et radix valerianae 12 weight portion、Radix Polygalae 12 weight portion and Rhizoma Acori Graminei 7 weight portion.

Its preparation method comprises the following steps:

The first step, Fructus Gardeniae, Folium Bambusae, Pheretima, Radix Polygoni Multiflori Preparata and Flos Rosae Rugosae are mixed, adding relative to mixture 3 times～5 times amount determining alcohol is the ethanol of 55%～65%, reflux, extract, 2～4 times, each 2 hours～3 hours, filters, filtrate merges, reclaiming ethanol, being concentrated into 70 DEG C of relative densities is the mastic of 1.30～1.32, standby；

Second step, is mixed in proportion surplus stock medical material, adds relative to mixture 3～5 times amount water, boils 2～4 hours, filters, and being concentrated into 70 DEG C of relative densities is the mastic of 1.27～1.29；

3rd step, the described mastic mixing first step, second step obtained, 55 DEG C～65 DEG C reduced vacuum dry, and get dry extract powder；

4th step, added ethanol in the described dried cream powder the 3rd step obtained, obtains containing alcohol mastic, and the alcohol content of described containing alcohol mastic is 65%～70%；Described containing alcohol mastic being sequentially carried out chilling treatment, precipitation process, filtration treatment, recovery Ethanol Treatment, obtains dealcoholysis mastic, wherein, the chilling treatment time is 30～40 hours；

5th step, will add cane sugar powder, activated carbon in described dealcoholysis mastic, be sequentially carried out heat treated, filtration treatment, dilution process, obtain semi-finished product；The weight ratio of described dealcoholysis mastic and described cane sugar powder is 1: 0.1～0.3；The weight ratio of described dealcoholysis mastic and described activated carbon is 1: 0.001～0.002；The time of described heat treated is 20～40 minutes, and temperature is 100 DEG C～110 DEG C；

6th step, the more described semi-finished product that the 5th step obtains are sequentially carried out filtration treatment, embedding process, sterilization treatment, obtain described Chinese medicine preparation oral liquid finished product.

Embodiment 2 tablet

nullEmbodiments provide a kind of for treating the heart schizoid endo-medicine of kidney disorder type，Its dosage form is tablet，In this medicine, the parts by weight of each raw medicinal material are: Mirabilitum crystallina 5 weight portion、Fructus Gardeniae 15 weight portion、Folium Bambusae 20 weight portion、Rhizoma Coptidis 25 weight portion、Rhizoma Bistortae 10 weight portion、The Radix Rehmanniae 5 weight portion、Radix Scrophulariae 10 weight portion、Cornu Bubali 3 weight portion、Lapis Micae Aureus 10 weight portion、Pheretima 10 weight portion、Radix Polygoni Multiflori Preparata 10 weight portion、Flos Rosae Rugosae 25 weight portion、FLOS MUME 15 weight portion、Nidus Vespae 25 weight portion、Radix Ranunculi Ternati 5 weight portion、Bombyx Batryticatus 25 weight portion、Succus Bambusae 10 weight portion、Concretio Silicea Bambusae 5 weight portion、Radix Platycodonis 10 weight portion、Bulbus Lilii 25 weight portion、Radix Asparagi 10 weight portion、Rhizoma Polygonati Odorati 15 weight portion、Rhizoma Polygonati 10 weight portion、Fructus Lycii 15 weight portion、Fructus Ligustri Lucidi 10 weight portion、Fructus Mori 15 weight portion、Carapax Et Plastrum Testudinis 3 weight portion、Folium Artemisiae Argyi 15 weight portion、Radix Trichosanthis 10 weight portion、Semen Ziziphi Spinosae 25 weight portion、Semen Platycladi 25 weight portion、Rhizoma et radix valerianae 16 weight portion、Radix Polygalae 10 weight portion and Rhizoma Acori Graminei 5 weight portion.

Its preparation method comprises the following steps:

The first step, is mixed in proportion described each raw medicinal material, adds the ethanol that determining alcohol is 85%～95% relative to mixture quality 2～4 times, is heated to reflux 1～3 hour, extracts, and filters and obtains the first extracting solution；Filter the medicinal residues obtained and add the ethanol that determining alcohol is 85%～95% relative to described medicinal residues quality 1～2 times, be heated to reflux 1～3 hour, extract, filter and obtain the second extracting solution；First extracting solution and the second extracting solution being merged, concentrating under reduced pressure removes alcohol solvent, dry, it is thus achieved that dry cream；

Second step, is placed in super micron mill by the dry cream that the first step obtains and pulverizes 1～2 hour, pulverizes, sieves, it is thus achieved that the micropowders of 300 order～400 orders；

3rd step, the micropowders that second step is obtained, add relative to the microcrystalline Cellulose of its quality 0.1～0.3 times, 0.05～0.15 times of lactose, the starch of 0.1～0.3 times, sieve, mix homogeneously, granulate, dry, add relative to 0.005～0.05 times of magnesium stearate of micropowders quality, granulate, tabletting, makes.

Embodiment 3 navel patch

Embodiments provide a kind of for treating the heart schizoid external used medicine of kidney disorder type, its dosage form is navel patch, and in this medicine, the parts by weight of each raw medicinal material are: Radix Angelicae Sinensis 15 weight portion, Pericarpium Zanthoxyli 7 weight portion, Radix Polygalae 8 weight portion, Cortex Cinnamomi 6 weight portion, Amylum Nelumbinis Rhizomatis 12 weight portion, the Rhizoma Atractylodis Macrocephalae 7 weight portion, Aloe 15 weight portion and the Radix Aucklandiae 7 weight portion.

Its preparation method comprises the following steps:

The first step, is mixed in proportion described each raw medicinal material, is ground into the powder of 40 order～60 orders, adds the ethanol that determining alcohol is 85～95% relative to mixture quality 2～4 times, is heated to reflux 1～3 hour, extracts, and filters and obtains the first extracting solution；Filter the medicinal residues obtained and add the ethanol that determining alcohol is 85～95% relative to described medicinal residues quality 1～2 times, be heated to reflux 1～3 hour, extract, filter and obtain the second extracting solution；First extracting solution and the second extracting solution being merged, concentrating under reduced pressure removes alcohol solvent, dry, it is thus achieved that dry cream, is ground into the powder of 100 order～200 orders；

Second step, dissolves stearic acid heating, and being maintained at temperature is 70 DEG C～80 DEG C, it is thus achieved that stearic acid liquid；It addition, potassium hydroxide, glycerol, ethyl hydroxybenzoate and distilled water to be pressed the part by weight mixing of 5:500:1:600, heating, maintain the temperature at 70 DEG C～80 DEG C, it is thus achieved that distilled water mixed liquor；Stearic acid liquid is slowly added in distilled water mixed liquor according to the part by weight of 1:100, stirs cooling, it is thus achieved that substrate simultaneously；

3rd step, the substrate obtained to second step adds the Chinese medicinal powder that the first step of equivalent obtains, and is constantly ground to uniformly, and heating obtains sticky paste, granulates, and after drying, obtains pill, coordinates medical proof fabric or special navel paster that pill is attached to umbilicus place.

Toxicity test

One, acute oral toxicity test

(1) experiment purpose: the peroral tablets of the embodiment of the present invention 2 is to the acute oral toxicity effect of mice and intensity.

(2) material and method:

A, tested material: peroral tablets of the present invention；

B, sample pre-treatments: weigh 15 parts of samples, add 500ml boiled water, soak 2 hours, as stock solution；

C, experimental animal: I grade of Kunming mouse, 20, female, male half and half, body weight 18-22g；Thered is provided by Shandong medical college Experimental Animal Center.

(3) test method: dose design is female for 6000m part/k part BW, male for 6000m part/k part BW, give tested material by 0.1ml/10 part BW per os gavage.Before gavage, animal fasting 12 hours, freely drink water.Give normal diet after gavage, observe two weeks, record poisoning symptom and death condition.

(4) result of the test: in 14 day observation period, animal subject reaction without exception, without dead, postmortem no abnormality seen.Female, male mice acute oral LD50 is more than 5000m part/k part/BW.Judge according to acute toxicity grading criteria in " disinfection technology standard " (1999), the nontoxic level in the true border of peroral tablets of the present invention.

Two, cumulative toxicity test report

(1) test method: tested material is the oral solutions of the embodiment of the present invention 1；Select I grade of Kunming mouse of 20 health, female, male each 10, dose design is a phase in every 4 days, each issue dosage respectively 0.10LD50,0.15LD50,0.22LD50,0.34LD50,0.50LD50, the LD50 female, male mice of this sample be 5000m part/k part BW (five dosage is 500,750,1100,1700,2500m part/k part BW).Within every 4 days, weigh once, adjust dosage, by 0.1ml/10 part BW per os gavage.After 20 days, animal occurs without death condition, off-test, calculates cumulative coefficient.

(2) result of the test: by ascending-dose to 20 days handss of tested material, female, buck all occurs without death condition.Calculate cumulative coefficient more than 5.Judging according to cumulative toxicity grade scale in " disinfection technology standard " (1999), mice cumulative toxicity is belonged to weak cumulative toxicity by Tablets.

Three, acute skin irritation test report

(1) experiment purpose: detection navel patch is to the stimulation/corrosiveness of laboratory animal skin and intensity.

(2) material and method:

A, tested material: the navel patch of the embodiment of the present invention 3；

B, tested material sample pre-treatments: weigh 15 parts of samples, heating is to melting；

C, laboratory animal: I grade of big ear white race rabbit, 4, female, body weight 2.1-2.3k part；Thered is provided by Shandong medical college biology department Experimental Animal Center.

(3) its spinal column both sides, back are cut by test method: the healthy family selecting skin intact exempts from 4 in test for first 24 hours by hair, the left and right each about 3cm × 3cm of unhairing area.Taking tested material 0.2ml during test to be applied on two layers of gauze of 2.5cm × 2.5cm, be applied to skin of unhairing surface, side, oilpaper covers, immobilization with adhesive tape.Opposite side skin is as blank.After closing 4 hours, dismantling, and go residual tested material with warm water cleaning, 1,24 and 48 hours after removing tested material are observed and are smeared position dermoreaction, and mark.

(4) experimental result: any erythema does not occur in laboratory animal skin, red and swollen, inflammation phenomenon.Judging according to skin wound repair standards of grading in " disinfection technology standard " (1999), animal skin stimulus intensity is belonged to nonirritant by ointment of the present invention.

Four, the repeatedly Skin Irritation Test testing result of the present invention is as follows:

(1) material and method:

A, experimental animal feeding environment room temperature 22 DEG C ± 2 DEG C, relative humidity: 60%-70%；

B, experimental animal: Japan large ear rabbit；Animal rank: regular grade；4, male；Body weight 2kg-3kg；

C, animal origin: Shandong medical college biology laboratory provides.

(2) method: according to Ministry of Public Health " cosmetics health specification " (version in 2002) " skin irritation/corrosion test " the 6.4th article " repeatedly Skin Irritation Test ".Sample treatment: tested material (navel patch of the embodiment of the present invention 3) heating is to melting.Test procedure: 24h before test, removes the hair of back part of animal spinal column both sides by hair clipper for children, removes scope 3cm × 3cm.Taking tested material 0.5mL, spread upon on the skin of unhairing of animal side, opposite side is as comparison, application area 2.5cm × 2.5cm；Smear every day once, smear 14d continuously.Smear cropping every time, remove residual tested material.Observed result after 1h, with reference to the scoring of " cosmetics health specification " (version in 2002) " skin irritation/corrosion test " skin wound repair standards of grading.

(3) result: all animals were smeared in process at 14 days, there is not erythema and edema phenomenon in tested skin.Animal subject repeatedly skin wound repair every animal integral mean value average every day is " 0 ".

Clinical data

Case selection: case selection heart kidney disorder type schizophrenic 168 example, male 80 examples, female 88 example, age 26-58 year, average 41.5 years old, the most elder of medical history 4 years, the shortest person 4 months.168 example patients being randomly divided into 4 groups, often organizes 42 example patients, respectively treatment group 1, treatment group 2, treatment group 3 and matched group, each group sex of patient, age, the course of disease and condition of illness are different in nature without significance difference after contrasting, and have statistical significance.

Diagnostic criteria: 1, have at least following two to be not secondary to disturbance of consciousness, disturbance of intelligence, elation or low, (1) recurrent verbal auditory ballucination；(2) significantly loosening of association, splitting of thought, speech are discontinuous, or the poverty of thought or poverty of content of thought；(3) thought be inserted into, withdrawn, sent out, thinking interruption or forced thinking；(4) passively, controlled, or known clearly experience；(5) vain hope of primary delusion or other absurdities；(6) thinking logic perversion, morbid symbolic thinking or neologism；(7) parathymia or substantially apathy；(8) tension syndrome, strange behavior or unwise behavior；(9) obvious hypobulia or shortage.2 and hope, hear, ask, cut dialectical further diagnosis to be qi stagnation and blood stasis type prolapse of lumbar intervertebral disc according to the traditional Chinese medical science.Meet above-mentioned 1,2 two conditions, be namely diagnosed as heart kidney disorder type schizophrenia.Exclusion standard: get rid of organic mental disorders, psychoactive drug substance and non-addictive substance caused by mental disorder.

Therapeutic Method:

Treatment group 1: take the tablet of the embodiment of the present invention 2, every day 3 times, each 4,4 weeks be a course for the treatment of, take 2-6 the course for the treatment of continuously；

Treatment group 2: the navel patch of the external embodiment of the present invention 3, every day twice, each one is affixed on umbilicus place, within 4 weeks, is a course for the treatment of, takes 2-6 the course for the treatment of continuously；

Treatment group 3: take the oral solutions of the embodiment of the present invention 1 navel patch of the external embodiment of the present invention 3, oral solutions every day three times, each 30ml, navel patch every day twice, each one is affixed on umbilicus place；Within 4 weeks, it is a course for the treatment of, takes 2-6 the course for the treatment of continuously；

Matched group: take Clozaril, every day twice, each 25mg, 4 weeks be a course for the treatment of, take 2-6 the course for the treatment of continuously.

Criterion of therapeutical effect: recovery from illness: psychotic symptoms is wholly absent, thinking compared with normal, is emotionally stable, social function recovers normal；Effective: psychotic symptoms major part disappears, thinking compared with normal is emotionally stable, and social function is substantially recovered, and insight has part to recover；Effective: psychotic symptoms partial disappearance, thinking is relatively random, and emotion is flat, and insight part is recovered；Invalid: symptom is without improvement.

Therapeutic outcome:

Referring to table 1 and table 2, as it can be seen from table 1 adopt the Drug therapy heart kidney disorder type schizophrenia of the present invention, relative to conventional medicament on therapeutic effect, have and be markedly improved；From table 2 it can be seen that adopt the Drug therapy heart kidney disorder type schizophrenia of the present invention, relative to conventional medicament, treating, the course for the treatment of significantly shortens.

Table 1 respectively organize respectively treatment 6 courses for the treatment of after Clinical efficacy comparison example

Group	Number of cases	Recovery from illness	Effective	Effectively	Invalid	Recovery from illness and obvious effective rate	Effective percentage
								Treatment group 1	42	13	14	10	5	(27) 64.3%	88.1%
Treatment group 2	42	14	15	10	3	(29) 69.0%	92.9%
								Treatment group 3	42	16	17	8	1	(33) 78.6%	97.6%
Matched group	42	5	9	15	13	(14) 33.3%	69.0%

The treatment respectively of 2 liang of table group was cured and effective number and time comparative example (%) after 3 courses for the treatment of

Group	Number of cases	The 2-3 course for the treatment of	The 4-5 course for the treatment of	6th course for the treatment of
					Treatment group 1	27	8(29.6%)	11(40.7%)	8(29.6%)
Treatment group 2	29	9(31.0%)	12(41.4%)	8(27.6%)
					Treatment group 3	33	11(33.3%)	15(45.6%)	7(21.2%)
Matched group	14	3(21.4%)	5(35.7%)	6(42.9%)

According to the clinical statistics in above table it can be seen that medicine provided by the invention have rapid-action, effective percentage is high, determined curative effect, safety is high, the advantage that has no side effect；Curing each group and effective follow-up of patients 1 year half, result is added up, 27 example patient in treatment group 1 simultaneously, 1 example recurrence in 13 examples of recovery from illness, and 1 example recurrence in 14 effective example patients, relapse rate is 7.4%；29 example patient in treatment group 2, without recurrence in 14 examples of recovery from illness, 1 example recurrence in 15 effective example patients, relapse rate is 3.4%；33 example patient in treatment group 3, without recurrence in 16 examples of recovery from illness, 1 example recurrence in 17 effective example patients, relapse rate is 3%；14 example patient in matched group, 1 example recurrence in 5 examples of recovery from illness, 2 example recurrence in 9 effective example patients, relapse rate is 21.4%；And over the course for the treatment of, matched group has patient the side effect such as Nausea and vomiting in various degree occur, and treatment group 1-3 does not find any untoward reaction.

The foregoing is only presently preferred embodiments of the present invention, not in order to limit the present invention, all within the spirit and principles in the present invention, any amendment of making, equivalent replacement, improvement etc., should be included within protection scope of the present invention.

Claims (6)

1. null1. it is used for treating the heart schizoid medicine of kidney disorder type，It is characterized in that，Described medicine includes endo-medicine and external used medicine，Described endo-medicine is made up of the raw medicinal material of following parts by weight: Mirabilitum crystallina 5-9 weight portion、Fructus Gardeniae 10-15 weight portion、Folium Bambusae 10-20 weight portion、Rhizoma Coptidis 15-25 weight portion、Rhizoma Bistortae 10-15 weight portion、Radix Rehmanniae 5-15 weight portion、Radix Scrophulariae 10-15 weight portion、Cornu Bubali 3-9 weight portion、Lapis Micae Aureus 3-10 weight portion、Pheretima 10-15 weight portion、Radix Polygoni Multiflori Preparata 10-20 weight portion、Flos Rosae Rugosae 15-25 weight portion、FLOS MUME 10-15 weight portion、Nidus Vespae 10-25 weight portion、Radix Ranunculi Ternati 5-10 weight portion、Bombyx Batryticatus 15-25 weight portion、Succus Bambusae 10-15 weight portion、Concretio Silicea Bambusae 5-15 weight portion、Radix Platycodonis 10-20 weight portion、Bulbus Lilii 15-25 weight portion、Radix Asparagi 10-20 weight portion、Rhizoma Polygonati Odorati 5-15 weight portion、Rhizoma Polygonati 10-15 weight portion、Fructus Lycii 15-25 weight portion、Fructus Ligustri Lucidi 10-17 weight portion、Fructus Mori 15-25 weight portion、Carapax Et Plastrum Testudinis 3-8 weight portion、Folium Artemisiae Argyi 10-15 weight portion、Radix Trichosanthis 5-10 weight portion、Semen Ziziphi Spinosae 10-25 weight portion、Semen Platycladi 15-25 weight portion、Rhizoma et radix valerianae 9-16 weight portion、Radix Polygalae 10-15 weight portion and Rhizoma Acori Graminei 5-12 weight portion；

   Described external used medicine is made up of the raw medicinal material of following parts by weight: Radix Angelicae Sinensis 10-20 weight portion, Pericarpium Zanthoxyli 5-10 weight portion, Radix Polygalae 5-12 weight portion, Cortex Cinnamomi 5-8 weight portion, Amylum Nelumbinis Rhizomatis 5-20 weight portion, Rhizoma Atractylodis Macrocephalae 5-9 weight portion, Aloe 10-20 weight portion and Radix Aucklandiae 5-12 weight portion.
2. null2. according to claim 1 for treating the heart schizoid medicine of kidney disorder type，It is characterized in that，In described endo-medicine, the parts by weight of each raw medicinal material are: Mirabilitum crystallina 7 weight portion、Fructus Gardeniae 12 weight portion、Folium Bambusae 15 weight portion、Rhizoma Coptidis 21 weight portion、Rhizoma Bistortae 12 weight portion、The Radix Rehmanniae 7 weight portion、Radix Scrophulariae 12 weight portion、Cornu Bubali 5 weight portion、Lapis Micae Aureus 7 weight portion、Pheretima 12 weight portion、Radix Polygoni Multiflori Preparata 15 weight portion、Flos Rosae Rugosae 22 weight portion、FLOS MUME 12 weight portion、Nidus Vespae 17 weight portion、Radix Ranunculi Ternati 7 weight portion、Bombyx Batryticatus 19 weight portion、Succus Bambusae 12 weight portion、Concretio Silicea Bambusae 11 weight portion、Radix Platycodonis 15 weight portion、Bulbus Lilii 21 weight portion、Radix Asparagi 15 weight portion、Rhizoma Polygonati Odorati 11 weight portion、Rhizoma Polygonati 12 weight portion、Fructus Lycii 21 weight portion、Fructus Ligustri Lucidi 14 weight portion、Fructus Mori 21 weight portion、Carapax Et Plastrum Testudinis 6 weight portion、Folium Artemisiae Argyi 13 weight portion、Radix Trichosanthis 6 weight portion、Semen Ziziphi Spinosae 22 weight portion、Semen Platycladi 21 weight portion、Rhizoma et radix valerianae 12 weight portion、Radix Polygalae 12 weight portion and Rhizoma Acori Graminei 7 weight portion；

   In described external used medicine, the parts by weight of each raw medicinal material are: Radix Angelicae Sinensis 15 weight portion, Pericarpium Zanthoxyli 7 weight portion, Radix Polygalae 8 weight portion, Cortex Cinnamomi 6 weight portion, Amylum Nelumbinis Rhizomatis 12 weight portion, the Rhizoma Atractylodis Macrocephalae 7 weight portion, Aloe 15 weight portion and the Radix Aucklandiae 7 weight portion.
3. null3. according to claim 1 for treating the heart schizoid medicine of kidney disorder type，It is characterized in that，In described endo-medicine, the parts by weight of each raw medicinal material are: Mirabilitum crystallina 5 weight portion、Fructus Gardeniae 15 weight portion、Folium Bambusae 20 weight portion、Rhizoma Coptidis 25 weight portion、Rhizoma Bistortae 10 weight portion、The Radix Rehmanniae 5 weight portion、Radix Scrophulariae 10 weight portion、Cornu Bubali 3 weight portion、Lapis Micae Aureus 10 weight portion、Pheretima 10 weight portion、Radix Polygoni Multiflori Preparata 10 weight portion、Flos Rosae Rugosae 25 weight portion、FLOS MUME 15 weight portion、Nidus Vespae 25 weight portion、Radix Ranunculi Ternati 5 weight portion、Bombyx Batryticatus 25 weight portion、Succus Bambusae 10 weight portion、Concretio Silicea Bambusae 5 weight portion、Radix Platycodonis 10 weight portion、Bulbus Lilii 25 weight portion、Radix Asparagi 10 weight portion、Rhizoma Polygonati Odorati 15 weight portion、Rhizoma Polygonati 10 weight portion、Fructus Lycii 15 weight portion、Fructus Ligustri Lucidi 10 weight portion、Fructus Mori 15 weight portion、Carapax Et Plastrum Testudinis 3 weight portion、Folium Artemisiae Argyi 15 weight portion、Radix Trichosanthis 10 weight portion、Semen Ziziphi Spinosae 25 weight portion、Semen Platycladi 25 weight portion、Rhizoma et radix valerianae 16 weight portion、Radix Polygalae 10 weight portion and Rhizoma Acori Graminei 5 weight portion；

   In described medicine for external use thing, the parts by weight of each raw medicinal material are: Radix Angelicae Sinensis 20 weight portion, Pericarpium Zanthoxyli 10 weight portion, Radix Polygalae 5 weight portion, Cortex Cinnamomi 8 weight portion, Amylum Nelumbinis Rhizomatis 15 weight portion, the Rhizoma Atractylodis Macrocephalae 9 weight portion, Aloe 20 weight portion and the Radix Aucklandiae 12 weight portion.
4. 4. the preparation method for treating the heart schizoid medicine of kidney disorder type according to any one of claim 1-3, it is characterised in that the dosage form of described endo-medicine is oral solutions, and its preparation method comprises the following steps:

   The first step, Fructus Gardeniae, Folium Bambusae, Pheretima, Radix Polygoni Multiflori Preparata and Flos Rosae Rugosae are mixed, adding relative to mixture 3 times～5 times amount determining alcohol is the ethanol of 55%～65%, reflux, extract, 2～4 times, each 2 hours～3 hours, filters, filtrate merges, reclaiming ethanol, being concentrated into 70 DEG C of relative densities is the mastic of 1.30～1.32, standby；

   Second step, is mixed in proportion surplus stock medical material, adds relative to mixture 3～5 times amount water, boils 2～4 hours, filters, and being concentrated into 70 DEG C of relative densities is the mastic of 1.27～1.29；

   3rd step, the described mastic mixing first step, second step obtained, 55 DEG C～65 DEG C reduced vacuum dry, and get dry extract powder；

   4th step, added ethanol in the described dried cream powder the 3rd step obtained, obtains containing alcohol mastic, and the alcohol content of described containing alcohol mastic is 65%～70%；Described containing alcohol mastic being sequentially carried out chilling treatment, precipitation process, filtration treatment, recovery Ethanol Treatment, obtains dealcoholysis mastic, wherein, the chilling treatment time is 30～40 hours；

   5th step, will add cane sugar powder, activated carbon in described dealcoholysis mastic, be sequentially carried out heat treated, filtration treatment, dilution process, obtain semi-finished product；The weight ratio of described dealcoholysis mastic and described cane sugar powder is 1: 0.1～0.3；The weight ratio of described dealcoholysis mastic and described activated carbon is 1: 0.001～0.002；The time of described heat treated is 20～40 minutes, and temperature is 100 DEG C～110 DEG C；

   6th step, the more described semi-finished product that the 5th step obtains are sequentially carried out filtration treatment, embedding process, sterilization treatment, obtain described Chinese medicine preparation oral liquid finished product.
5. 5. the preparation method for treating the heart schizoid medicine of kidney disorder type according to any one of claim 1-3, it is characterised in that the dosage form of described endo-medicine is tablet, and its preparation method comprises the following steps:

   The first step, is mixed in proportion described each raw medicinal material, adds the ethanol that determining alcohol is 85%～95% relative to mixture quality 2～4 times, is heated to reflux 1～3 hour, extracts, and filters and obtains the first extracting solution；Filter the medicinal residues obtained and add the ethanol that determining alcohol is 85%～95% relative to described medicinal residues quality 1～2 times, be heated to reflux 1～3 hour, extract, filter and obtain the second extracting solution；First extracting solution and the second extracting solution being merged, concentrating under reduced pressure removes alcohol solvent, dry, it is thus achieved that dry cream；

   Second step, is placed in super micron mill by the dry cream that the first step obtains and pulverizes 1～2 hour, pulverizes, sieves, it is thus achieved that the micropowders of 300 order～400 orders；

   3rd step, the micropowders that second step is obtained, add relative to the microcrystalline Cellulose of its quality 0.1～0.3 times, 0.05～0.15 times of lactose, the starch of 0.1～0.3 times, sieve, mix homogeneously, granulate, dry, add relative to 0.005～0.05 times of magnesium stearate of micropowders quality, granulate, tabletting, makes.
6. 6. the preparation method for treating the heart schizoid medicine of kidney disorder type according to any one of claim 1-3, it is characterised in that the dosage form of described external used medicine is navel patch, and its preparation method comprises the following steps:

   The first step, is mixed in proportion described each raw medicinal material, is ground into the powder of 40 order～60 orders, adds the ethanol that determining alcohol is 85～95% relative to mixture quality 2～4 times, is heated to reflux 1～3 hour, extracts, and filters and obtains the first extracting solution；Filter the medicinal residues obtained and add the ethanol that determining alcohol is 85～95% relative to described medicinal residues quality 1～2 times, be heated to reflux 1～3 hour, extract, filter and obtain the second extracting solution；First extracting solution and the second extracting solution being merged, concentrating under reduced pressure removes alcohol solvent, dry, it is thus achieved that dry cream, is ground into the powder of 100 order～200 orders；

   Second step, dissolves stearic acid heating, and being maintained at temperature is 70 DEG C～80 DEG C, it is thus achieved that stearic acid liquid；It addition, potassium hydroxide, glycerol, ethyl hydroxybenzoate and distilled water to be pressed the part by weight mixing of 5:500:1:600, heating, maintain the temperature at 70 DEG C～80 DEG C, it is thus achieved that distilled water mixed liquor；Stearic acid liquid is slowly added in distilled water mixed liquor according to the part by weight of 1:100, stirs cooling, it is thus achieved that substrate simultaneously；

   3rd step, the substrate obtained to second step adds the Chinese medicinal powder that the first step of equivalent obtains, and is constantly ground to uniformly, and heating obtains sticky paste, granulates, and after drying, obtains pill, coordinates medical proof fabric or special navel paster that pill is attached to umbilicus place.