CN102886013A - Shiniu antipyretic oral liquid - Google Patents
Shiniu antipyretic oral liquid Download PDFInfo
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- CN102886013A CN102886013A CN2012104152998A CN201210415299A CN102886013A CN 102886013 A CN102886013 A CN 102886013A CN 2012104152998 A CN2012104152998 A CN 2012104152998A CN 201210415299 A CN201210415299 A CN 201210415299A CN 102886013 A CN102886013 A CN 102886013A
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Abstract
The application discloses a Shiniu antipyretic oral liquid which is prepared by processing the following traditional Chinese medicines and water, wherein the traditional Chinese medicines comprise the components by mass percent: 39% of raw gypsum, 6.5% of cornu bubali, 3.25% of radix scutellariae, 3.25% of coptidis rhizome, 6.5% of radix scrophulariae, 6.5% of radix rehmanniae, 1.96% of fructus forsythiae, 1.96% of platycodon grandiflorum, 1.96% of bupleurum, 1.96% of calvatia gigantea, 1.96% of fructus arctii, 1.96% of gardenia jasminoides, 0.67% of stiff silkworm, 0.67% of rhizoma cimicifugae, 1.96% of radix isatidis, 1.3% of tangerine peel, 1.3% of liquorice, 3.25% of rhizoma anemarrhenae, 2.17% of the root bark of the peony tree, 2.17% of red peony root, 6.5% of fresh bamboo leaves, 2.17% of American ginseng and 1.08% of fructus amomi. The Shiniu antipyretic oral liquid has the advantages of good heat clearing effect, low side effect and good patient tolerance.
Description
Technical field
The invention discloses a kind of health promoting beverage, specifically refer to a kind of stone cattle antipyretic oral liquid, the stone cattle is being collectively referred to as at the general of the field of Chinese medicines of Gypsum Fibrosum and Cornu Bubali.
Background technology
In the clinical treatment of the fervescence that influenza, suppurative tonsillitis or hand-foot-mouth disease etc. are caused, generally all adopt Western medicine to treat, such as acetyl aminophenol, dexamethasone injection or nimesulide granule etc., yet all there is following side effect in this class antipyretic:
(1) the main side effect of acetyl aminophenol is gastrointestinal reaction;
(2) major side effects of dexamethasone injection (being the glucocorticosteroid hormone) is to bring out gastric ulcer, dripping sweat so that dehydration, electrolyte disturbance.Share the blood glucose that to raise with antidiabetic drug, share with cardiac glycoside, can increase the generation of digitalis toxicity and cardiac arrhythmia, share with row's potassium diuretic, can cause serious hypokalemia, and weaken the natriuretic diuretic effect of diuretic owing to water-sodium retention.Therefore all careful usefulness or coolings of forbidding dexamethasone such as gastric ulcer, diabetes, hypertension, coronary heart disease and patients with heart failure;
(3) the main side effect of nimesulide granule be feel sick, stomachache and induced ulcer, so because of this product mainly by the careful usefulness of renal excretion renal insufficiency person, renal failure person's forbidding.So gastrointestinal disease patient and accept anticoagulant treatment or the careful usefulness of patient of medicament for resisting platelet aggregation.
Summary of the invention
The objective of the invention is the shortcoming and defect that exists in order to overcome prior art, and the stone cattle that a kind of heat clearing away is effective, side effect is little and patient's tolerance is good antipyretic oral liquid is provided.
For achieving the above object, technical scheme of the present invention is to include it to be processed by following Chinese medicine and water, and described Chinese medicine includes component, by percentage to the quality:
Gypsum Fibrosum 39% Cornu Bubali silk 6.5% Radix Scutellariae 3.25% Rhizoma Coptidis 3.25% Radix Scrophulariae 6.5% Radix Rehmanniae 6.5% Fructus Forsythiae 1.96% Radix Platycodonis 1.96% Radix Bupleuri 1.96% Lasiosphaera Seu Calvatia 1.96% Fructus Arctii 1.96% SHANZHIZI 1.96% Bombyx Batryticatus 0.67% Rhizoma Cimicifugae 0.67% Radix Isatidis 1.96% Pericarpium Citri Reticulatae 1.3% Radix Glycyrrhizae 1.3% Rhizoma Anemarrhenae 3.25% Cortex Moutan 2.17% Radix Paeoniae Rubra 2.17% bright Folium Bambusae 6.5% Radix Panacis Quinquefolii 2.17% Fructus Amomi 1.08%.
Of the present invention have a following effect: nourishing YIN and clearing away heat, supplementing QI for promoting the production of body fluid, replenishing vital QI with drugs of warm nature taste.The product of the large multiplex nourishing YIN to reduce heat of the selection of each component of the present invention are different from the product that diaphoresis expels the heat-evil.The product of YIN nourishing have guaranteed the full of body fluid in cooling, positive so-called sweat and blood being derived from the same source, and undue diaphoresis expels the heat-evil and can cause the qi-blood-body fluid loss, and healthy energy is not solid, and vigour is deficient.Have because the product of clearing up internal heat by using drugs of bitter in taste and cold in nature are arranged in the prescription, the cold product of fearing hardships injure one's stomach, therefore give the product of suitable QI invigorating nourishing the stomach, make heresy dispel and just do not hinder.After taking this drink slight sweating is only arranged, dangerous without dripping sweat and collapse.Unless serious the spleen and stomach illness is arranged, and outside cold-excess syndrome body constitution can not tolerate than severe one, more than have no any untoward reaction.
The present invention all has obvious cooling effect to the high heat that influenza, suppurative tonsillitis or hand-foot-mouth disease etc. cause, and influenza is had good preventive effect.And to some leukopenia, lower for the resistance, Multiple Classes of Antibiotics tolerance or irritated patient there are good therapeutic effect, meet the theory of Epidemic Febrile Disease treatment, side effect is little, and patient's tolerance is good, be fit to extensively promote, to reduce antibiotic abuse or excessive application.
Below in conjunction with the specific embodiment the present invention is done further introduction.
The specific embodiment
Below by embodiment the present invention is carried out concrete description; only be used for the present invention is further specified; can not be interpreted as the restriction to protection domain of the present invention, the technician in this field can make some nonessential improvement and adjustment to the present invention according to the content of foregoing invention.
[embodiment] is by following drug matching, by percentage to the quality:
Gypsum Fibrosum 39% Cornu Bubali silk 6.5% Radix Scutellariae 3.25% Rhizoma Coptidis 3.25% Radix Scrophulariae 6.5% Radix Rehmanniae 6.5% Fructus Forsythiae 1.96% Radix Platycodonis 1.96% Radix Bupleuri 1.96% Lasiosphaera Seu Calvatia 1.96% Fructus Arctii 1.96% SHANZHIZI 1.96% Bombyx Batryticatus 0.67% Rhizoma Cimicifugae 0.67% Radix Isatidis 1.96% Pericarpium Citri Reticulatae 1.3% Radix Glycyrrhizae 1.3% Rhizoma Anemarrhenae 3.25% Cortex Moutan 2.17% Radix Paeoniae Rubra 2.17% bright Folium Bambusae 6.5% Radix Panacis Quinquefolii 2.17% Fructus Amomi 1.08%.
Its processing method is that the Cornu Bubali silk soaks separately, and Gypsum Fibrosum soaks separately, and Fructus Amomi soaks separately, and all the other medicines soak together.Medicine soaked five hours with daily drinking water.The Cornu Bubali silk was decocted first one hour.Lower behind the Gypsum Fibrosum, little fire at present after second time intense fire of decocting boils.Fructus Amomi decocts to differ from when taking the dish out of the pot in ten minutes at second time and puts into.Except the medicine of special handling, remaining medicine need decoct twice, and the first pass intense fire is boiled, slow fire boiling 20 minutes.Second time intense fire is boiled, slow fire boiling 30 minutes.The medicine juice of twice decoction is converted together altogether 500ml, it is stirred evenly minute three decoction being taken warmly.
[testing clinical example]
Experiment number 50 people.A. women 26 people wherein, male 24 people.B. ethnic groups: 6 people, 44 people of Han nationality.C.1 to 12 years old 21 people, 12 to 20 years old 2 people, 20 to 30 years old 5 people, 22 people more than 30 years old.D. merge pneumonia 4 people, merge acute/chronic bronchitis 23 people, merge asthma 3 people, merge suppurative tonsillitis 15 people, merge hydrothorax 1 people, merge urinary tract infection 1 people, merge bleeding hemorrhoids 1 people, merge rhinitis 1 people, merge gastritis 1 people.E. body temperature is all between 39 ° of C to 40 ° of C.F. repeatedly had a fever 1 to 3 day.
Experimental result: except a people because merging gastric ulcer, can not tolerate medicine, cooling-down effect is not good, remaining all in two days temperature be down to normally.
Matched group: 50 people.1 to 12 years old 21 people, 29 people more than 12 years old.Above 50 people all use dexamethasone injection 3mg not wait to 5mg, and 2 to the 4 hours persistent period of bringing down a fever are not waited.Wherein child's great majority are initial used " acetaminophen suspension " cooling-down effect sustainable 1 to 2 hour.The child of adult and use " acetaminophen suspension " weak effect has used " nimesulide granule " 1 to 2 bag, sustainable 6 to 12 hours of its cooling-down effect in succession.The patient uses above-mentioned antipyretic continuously, and still repeatedly high heat to 39 is to 40 ℃ after 3 days, and the heat clearing away cold decoction that takes the application was all brought down a fever in one day not again repeatedly.
[pharmacology analysis]
Monarch drug: Gypsum Fibrosum (chemical composition: CaSO
4.2H
2O)
The property of medicine: acrid in the mouth, sweet, cold in nature.
Pharmacological property:
1. to central nervous system's effect: a refrigeration function: Gypsum Fibrosum has certain refrigeration function to the artificial fever animal, and to the normal body temperature animal without cooling effect; The induced by endotoxin heating has obvious refrigeration function, when Gypsum Fibrosum is analgesic, suppresses simultaneously sweat centers, and the not diaphoresis therefore it is analgesic is particularly suited for high heat.The b sedation: contained calcareous of Gypsum Fibrosum has inhibitory action to neuromuscular, therefore the tic that causes for irritated and high heat has certain effect.The c analgesic activity: zoopery shows that the intravenous fluid made from Gypsum Fibrosum has obvious analgesic activity.
2. to cardiovascular effect: when the Gypsum Fibrosum supernatant is heavy dose of cardiovascular system is presented inhibitory action.Intravenous injection Gypsum Fibrosum supernatant can make the blood flow of the thigh tremulous pulse of rabbit and cat be momentary minimizing, increases thereafter, and coronary artery blood flow is reduced; Respiration inhibition when increasing dosage, blood pressure drops, blood flow reduces, decreased heart rate.The tachycardia that this effect causes when hot to height, the nervous good therapeutical effect that has uncomfortable in chest; To suffering from hypertension, the patient's of sinus tachycardia high heat has very large benefit especially.
3. antiinflammatory action: the intravenous fluid so that Gypsum Fibrosum is made has obvious and lasting inhibitory action to the inflammation early reaction.
4. immunologic enhancement
Cornu Bubali silk (chemical composition: contain cholesterol, heart tonifying composition, peptide class, angle fiber, and the several amino acids such as serine, glycine, aspartic acid, arginine, threonine, glutamic acid, proline, leucine, tyrosine, phenylalanine.) property of medicine: bitter in the mouth, salty, cold in nature.
Pharmacological property:
1. calmness and anticonvulsant action: Cornu Bubali ether or ethanol extract all have obvious sedation to rat.The Cornu Bubali decoct can prolong the time-to-live of eclamptogenic incubation period of mice strychnine and mice, can work in coordination with the pentobarbital sodium Sleeping Time Prolong Ed, but the effect of pentetrazole and caffeine is without impact.
2. to the effect of blood system: the Cornu Bubali decoct can obviously shorten the mice bleeding time, shortens KPTT, prothrombin time, thrombin time in the DIC rat model blood, the increased platelets counts number.Cornu Bubali extract can reduce eosinophilic granulocyte's number, increases lymphocyte number.
3. to the effect of Pituitary Adrenal cortex system: the Cornu Bubali decoct also can prolong the large life span of adrenalectomy element rat.
4. to the effect of cardiovascular system: the aqueous solution of Cornu Bubali decoct or extract has the isolated heart of animal strengthens the effect of shrinking, and can make it to stop fighting in systole.Decoct descends after the blood pressure of anesthetized cat and rabbit is slightly raise, and recovers very soon at last normal, and minority is visible obviously to raise.
5. other effects: Cornu Bubali can obviously reduce the permeability of blood capillary, significantly strengthens the phagocytic function of reticuloendothelial system.Pulvis Cornus Bubali Concentratus decocting liquid can obviously reduce escherichia coli endotoxin induced mice mortality rate.The Cornu Bubali decoct can also excited isolated rabbit intestinal, and its tension force is increased.
Ministerial drug: (chemical composition: scutellariae,radix contains flavone compound to Radix Scutellariae: baicalin, neobaicalein, skullcapflavone I, baicalin, wogonin, wogonoside, oroxylin A, dihydro oroxylin A, 7-methoxyl group baicalin, wogonin-5-β-D-Glucose glycosides, chrysin, chrysin-6-C-beta-glucosidase-8-C-α-L-arabinose glycosides, oroxylin A-7-O-glucuronide, 5-hydroxyl-7,8-dimethoxy flavone, 5,2
'-dihydroxy-6,7,8-trimethoxy flavone, 2
', 5,8-trihydroxy-7-methoxy flavone, 5,7,2
', 6
'-kaempferol (2S)-2
', 5,6
', 7-tetrahydroxy flavanone, Norwogonin, dihydro baicalin, viscidulin I, II, III, tenaxin Ⅱ, left-handed eriodictyol, Herba Scutellariae Barbatae kind element etc.) property of medicine: bitter in the mouth, cold in nature.
Pharmacological property: 1. resisting pathogenic microbes effect, the antimicrobial spectrum of Radix Scutellariae is wider, and water decoction all has in various degree inhibition or killing action external to staphylococcus aureus, streptococcus pneumoniae, Hemolytic streptococcus, meningococcus, dysentery bacterium, diphtheria corynebacterium, anthrax bacillus, escherichia coli, bacillus pyocyaneus, Bacillus typhi, Salmonella paratyphi, Bacillus proteus, helicobacter pylori, vibrio cholera etc.Bacillary inflammatory swelling has certain effect to Radix Scutellariae to department of otorhinolaryngology in vivo, and its pathogenic bacterium are take staphylococcus as main.The Radix Scutellariae decoct has certain inhibitory action to the Asia influenza A virus; Epidemic Hemorrhagic Fever viral infection neonatal rat has certain protective role.5,7,4
'Trihydroxy-8-methoxy flavone is one of effective ingredient of Radix Scutellariae resisiting influenza virus.Radix Scutellariae water decoction and alcohol extract can suppress leptospira, during high concentration leptospira are had killing action.
2. to the immune system effect: the Radix Scutellariae water extract can suppress antigen is combined with IgE, suppresses histamine release of mast cell, to the models of passive skin irritability of rats reaction with to the Cavia porcellus allergic asthma inhibitory action is arranged all.Baicalin and baicalin are effective to experimental asthma, and antihistamine is still arranged, cholinolytic and the effect of papaverine sample.
3. the central nervous system is acted on: the Radix Scutellariae decoct has refrigeration function to typhoid fever paratyphoid fever mixed vaccine pyrogenicity rabbit.Baicalin with contain Radix Scutellariae serum the effect that stops endogenous pyrogen to generate all arranged.Radix Scutellariae has obvious sedation.
4. to Cardiovascular System: the intravenous injection of Radix Scutellariae alcohol extract dog can make anaesthetized dog blood pressure descend.Radix Scutellariae preserved material gavage makes chronic renal hypertension dog blood pressure drops, decreased heart rate.
Rhizoma Coptidis (chemical composition: rhizome Han Xiao ?alkali, Biao Xiao ?alkali, coptisine, 13-methyl-.psi.-coptisine. ， Xiao ?red alkali, palmatine, Columbamine, jateorhizine, magnoflorine, ferulic acid, obacunone, obakulactone.）
The property of medicine: bitter in the mouth, cold in nature.
Pharmacological property: 1. resisting pathogenic microbes effect: antibacterial action: experiment in vitro proves, Rhizoma Coptidis He Xiao ?alkali all have broad-spectrum antibacterial action, to staphylococcus, streptococcus, streptococcus pneumoniae, vibrio cholera, anthrax bacillus and in Song the dysentery bacterium the Salmonella stronger antibacterial action is all arranged; Bacillus subtilis, bordetella pertussis, diphtheria corynebacterium, bacillus pestis, Brucella, tubercule bacillus also there is antibacterial action.
Antiinflammatory, promote immunization of cell: the Rhizoma Coptidis methanolic extract has the effect that suppresses granulation tissue hyperplasia.Experiment in vitro confirm Xiao ?alkali have and suppress the effect that the human polymorphonuclear leukocyte produces leukotriene B4, also can suppress the granulation tissue growth.Xiao ?alkali can strengthen the phagocytic function of rabbit reticuloendothelial system, be a kind of cellular immunization promoter.
(chemical composition: Folium Bambusae contains alkaloid to bright Folium Bambusae, aminoacid, organic acid, phenolic compound and tannin, saponin, reducing sugar, protein, polysaccharide and glycoside, anthraquinone, coumarin and terpene lactone chemical compound, steroidal and chlorophyll.Also contain 18 kinds of elements of aluminum, barium, zirconium, titanium, lead, stannum, gallium, strontium, ferrum, zinc, magnesium, calcium, manganese, nickel, copper, silver and boron and silicon.
The property of medicine: sweet in the mouth, light, cold in nature.
Radix Scrophulariae (chemical composition: root contains cyclenes fan terpenoid, such as rhinanthin, and Harpagide, aucubin, 6-O-methycatalpol, 3,4
'-dimethyl Angola glycosides A, Radix Scrophulariae cyclic ethers and Radix Scrophulariae three ester glycosides.Still contain the cyclopenta furan compound, such as Radix Scrophulariae kind aglycon, Radix Scrophulariae kind glycosides A, B.Also contain agedoite, volatile oil and fatty acid etc.）
The property of medicine: sweet in the mouth, hardship, salty, cold nature.
Pharmacological property: 1. resisting pathogenic microbes effect: Radix Scrophulariae has significant antibacterial action to staphylococcus aureus, bacillus pyocyaneus, Bacillus typhi, group B streptococcus, escherichia coli, diphtheria corynebacterium, shigella flexneri etc.Radix Scrophulariae water logging agent is external to have certain inhibitory action to ulotrichy denticle born of the same parents tinea bacterium, acrothesium floccosum, trichophyton mentagrophytes, Du's big belly denticle born of the same parents tinea bacterium difficult to understand.
The Radix Rehmanniae (chemical composition: Radix Rehmanniae contains multiple methods of glycosides, wherein again take cyclenes fan terpene and glycoside thereof as main)
The property of medicine: sweet-bitter flavor, cold nature.
Pharmacological property: 1. antiinflammatory action: rat paw edema has obvious inhibitory action due to Rehmannia glutinosa Libosch Water decoct and the pure preserved material PARA FORMALDEHYDE PRILLS(91,95), and the Rehmannia glutinosa Libosch Water extract has obvious inhibitory action to the mice capillary permeability increase that histamine and acetic acid cause.
2. on central nervous system's impact: Radix Rehmanniae has obvious sedation,, suppress the mice autonomic activities, strengthen the syngignoscism of subliminal hypnosis amount pentobarbital sodium and penthiobarbital, the excitation of antagonism caffeine.
(chemical composition: rhizome contains 1-timosaponin A-1-I, A-II, A-III, A-IV, B-I, B-II to the Rhizoma Anemarrhenae, also contains 1-timosaponin A-1 2, goes galactose to replace and accuses saponin etc.）
The property of medicine: bitter in the mouth, little sweet, cold in nature.
Pharmacological property: 1. resisting pathogenic microbes effect: the Rhizoma Anemarrhenae all has stronger inhibitory action to gram positive bacterias such as Bacillus typhi, Salmonella paratyphi, dysentery bacterium, Bacillus proteus, escherichia coli, bacillus pyocyaneus and staphylococcus, Hemolytic streptococcus, streptococcus pneumoniae, bordetella pertussis.Rhizoma Anemarrhenae ethanol, ether extractum has very strong inhibitory action to H37Rr Bacillus tuberculosis subspecies, and Rhizoma Anemarrhenae water decoction also has stronger inhibitory action to Candida albicans.
2. antiinflammatory action: the Rhizoma Anemarrhenae has significant antiinflammatory action, and Rhizoma Anemarrhenae water extract and total polysaccharides can obviously suppress capillary permeability, and becomes dose dependent.Total polysaccharides may be the anti-inflammatory activity main component of the Rhizoma Anemarrhenae.The Fructus Mangifera Indicae glycosides has immunosuppressive action, but does not affect cell viability.
Cortex Moutan (chemical composition: root bark contains paeonol, paeonoside, the former glycosides of paeonol, the new glycosides of paeonol, peoniflorin, oxypaeoniflorin etc.)
The property of medicine: acrid in the mouth, hardship, cold nature.
Pharmacological property: 1. the analgesia, antiinflammatory action: the paeonol lumbar injection can improve the threshold of pain, its effect without the tolerance phenomenon.Paeonol has inhibitory action to animal abdominal cavity, capillary of skin permeability.Cortex Moutan can suppress the biosynthesis of PGE2 by the permeability of inflammation-inhibiting tissue, thereby suppresses various inflammatory reactions, and its antiinflammatory action does not rely on pitutary-adrenal system.
2. resisting pathogenic microbes effect: paeonol, peoniflorin, oxypaeoniflorin have antibacterial action.Cortex Moutan is external all to have stronger antibacterial action to Bacillus typhi, escherichia coli, Bacillus proteus, bacillus subtilis, staphylococcus, streptococcus pneumoniae, Hemolytic streptococcus etc.The Cortex Moutan infected by influenza has direct repression, and antiviral effective ingredient is 1,2,3,4,6-Penta-O-galloyl-D-glucopyranose.
Radix Paeoniae Rubra (chemical composition: the root master contains peoniflorin, and other contains benzoylpaeoniflorin)
The property of medicine: acid, hardship is slightly cold.
Pharmacological property: 1. resisting pathogenic microbes effect: the Radix Paeoniae Rubra preparation is external to have stronger inhibitory action to dysentery bacterium, bacillus pyocyaneus, escherichia coli, staphylococcus, streptococcus pneumoniae, Hemolytic streptococcus, vibrio cholera and some pathomycete.The Radix Paeoniae Rubra decoct in vitro has inhibitory action to herpesvirus, influenza virus, parainfluenza virus and enterovirus.
2. the central nervous system is acted on: peoniflorin has sedation and weak anti-pentetrazole convulsion effect is arranged.Peoniflorin and Radix Paeoniae extractum preparation can resist the convulsions that strychnine brings out, and mice normal body temperature and artificial fever body temperature are had cooling effect.Peoniflorin has analgesic activity.
Adjuvant drug: (fruit contains wooden lipoid substance to Fructus Forsythiae: phillyrin, Fructus Forsythiae aglycon, dextrorotation pinoresinol, dextrorotation (+)-Pinoresinol glucoside.Flavone compound: rutin.Vinylbenzene analog derivative: Fructus Forsythiae fat glycosides A, C, D, E, Fructus Forsythiae kind glycosides, salidroside.Ethyl cyclohexanol analog derivative: cornine, Fructus Forsythiae Hexalin, different Fructus Forsythiae Hexalin, Fructus Forsythiae Hexalin oxide, Fructus Forsythiae hexamethylene alcohol ketone, Fructus Forsythiae Hexalin glycosides A, B, C.Triterpenoid compound: betulic acid, oleanolic acid, ursolic acid, β-Amyrin acetic acid fat, different Lignum Dalbergiae Odoriferae terpenol acetas, 20-(S)-and Da Ma-24-alkene-3 β, 20-glycol-3-acetas etc.）
The property of medicine: bitter in the mouth, suffering, cold nature.
Pharmacological property: 1. resisting pathogenic microbes effect: the antimicrobial spectrum of Fructus Forsythiae is wider, multiple Grain-positive and negative bacterium all there is inhibitory action, such as staphylococcus aureus, streptococcus pneumoniae, Hemolytic streptococcus, dysentery bacterium, history Shigella flexneri, bacillus pestis, Bacillus tuberculosis, Bacillus typhi, vibrio cholera, Salmonella paratyphi, shigella flexneri, escherichia coli, Bacillus proteus, diphtheria corynebacterium, helicobacter pylori etc.Antibiotic effective ingredient is phillyrin.Volatile Oil of Forsythia Suspensa Seeds Emulsion dialogue normal complexion Oidium tropicale all has obvious inhibitory action, and Asia influenza A virus and rhinovirus-17 type are had inhibitory action.
2. analgesic, antiinflammatory action: Fructus Forsythiae decoct gavage can make heating rabbit body temperature significantly descend, and recovers normal after 1 hour, also can be down to below the normal body temperature subsequently.Forsythinol solution of extract lumbar injection has very significantly exudation effect and reduces the effect of scorching kitchen range wall of micrangium fragility.Fructus Forsythiae still can promote the formation of inflammatory barrier.Fructus Forsythiae injection lumbar injection has obvious inhibitory action to rat Ovum Gallus domesticus album pedal swelling, and can promote the phagocytosis to the mice inflammatory cell.
Radix Platycodonis (chemical composition: root contains multiple saponin, has got 18 kinds of triterpene saponin: platycodin A, C, D, D2, D3, remove celery glycosyl Platycodin D, D3,2
' '-O-acetyl group Platycodin D 2,3 ' '-O-acetyl group Platycodin D 2, polygalic acid D, D2,2
' '-O-acetyl group polygalic acid D, D2,3 ' '-O-acetyl group polygalic acid D, D2, Radix Platycodonis thuja acid-A methyl ester, 2-O-methyl Radix Platycodonis thuja acid-A methyl ester, Radix Platycodonis thuja acid-A lactone, wherein main constituent Platycodin D.）
The property of medicine: bitter in the mouth, suffering, property is flat.
Pharmacological property: 1. eliminate the phlegm, antitussive effect: the Radix Platycodonis decoct can make the respiratory tract secretion of anesthetized dog and cat strengthen.Platycodin can reflexive cause mild nausea to the stimulation of gastric mucosa and pharyngolaryngeal mucosa, strengthens the respiratory tract glandular secretion, and the dilution sputum makes the sputum that is stranded in the bronchus be easy to discharge, thus the performance phlegm-dispelling functions.Platycodin still has certain antitussive effect.
2. eliminate the phlegm, antitussive effect: platycodin has preferably antiinflammatory action, and foot swelling has stronger antiphlogistic effects due to the thick platycodin on Carrageenan of rats gavaged and the acetic acid, and granuloma induced by implantation of cotton pellets is remarkable inhibitory action.Platycodin can also significantly reduce the saturating property of blood capillary of anaphylactic shock mice.The Radix Platycodonis water extract can strengthen M φ phagocytic function, strengthens the sterilizing power of neutrophilic leukocyte, improves the activity of lysozyme, improves the inflammation part blood circulation, impels inflammation to take a turn for the better.
3. analgesic, analgesic activity: Radix Platycodonis can suppress the rat temperature that beer yeast causes and raise, and the zoopery pain reaction is all had obvious inhibitory action.The effect of oral thick saponin 200mg/kg and aspirin and aminophenazone is suitable.
Radix Bupleuri (chemical composition: Radix Bupleuri: contain volatile oil in the root, in valeric acid is arranged, caproic acid, enanthic acid, the 2-heptenoic acid, sad, 2-heptenoic acid, n-nonanoic acid, 2-nonenoic acid, phenol, ortho-, meta-or p-methoxyphenol etc.）
The property of medicine: bitter in the mouth, suffering, cold nature.
Pharmacological property: 1. 1. refrigeration function of couple central nervous system's effect: the aqueous solution of subcutaneous injection bupleurumol extractum causes that to the intravenous rabbit Escherichia Coli Injection heating has obvious refrigeration function.The water decoction of Radix Bupleuri is sent out expired typhoid fever polyvalent vaccine caused rabbit also same refrigeration function.Radix Bupleuri root decocting liquid can make the rabbit body temperature of intramuscular injection fermented milk pyrogenicity obviously descend to the rabbit gavage.Oral saikoside not only can make Typhoid and paratyphoid mixed vaccine pyrogenicity rat temperature descend, and can make the normal rat cooling of body temperature.Saikogenin A also has the cooling effect of bringing down a fever significantly.Radix Bupleuri total volatile oil lumbar injection can make the rat temperature of beer yeast suspension pyrogenicity significantly descend.2. sedation: saikoside and Saikogenin A etc. all has obvious sedation.
3. analgesic activity: the thick saponin of Radix Bupleuri has obvious analgesic activity to Experimental Mice
2. antiinflammatory action: rat paw edema all has obvious inhibitory action due to saikoside and the Radix Bupleuri volatile oil lumbar injection, on Carrageenan. and it is swollen that saikoside still can suppress the Mus foot that dextran, 5-HT, Oleum Tiglii or acetic acid causes.Saikoside a and b have exudation and anti-granuloma effect.Saikoside is to many inflammatory processes, comprise ooze out, capillary permeability, the release that causes scorching medium, leukoplania and connective tissue proliferation etc. be all influential.
3, resisting pathogenic microbes Radix Bupleuri decoct has inhibitory action external to growth of bacillus tubercle, and staphylococcus aureus is had slight inhibitory action, and plasmodium and leptospira are also had inhibitory action.Radix Bupleuri decocting liquid infected by influenza A3 also has inhibitory action; Saikoside a, d infected by influenza also have inhibitory action.
(chemical composition: the purple Calvatia contains cavatic acid to Lasiosphaera Seu Calvatia; Calvatia gigantea contains α-amylase; Reticulate pattern Ma Bo Han Ma Bo acid, melanin, lipoid, fatty acid, aromatic acid and protein etc.)
The property of medicine: acrid in the mouth, property is flat.
Pharmacological property: 1, antibacterial action extracts the acid of De Ma Bo bacterium from the fermentation liquid of purple Tu Ma Bo antibacterial activity.Metabolite in its culture fluid has antibiotic and antifungal activity.The water logging agent has inhibitory action to Microsporum ferrugineum etc.
2, anastalsis can be stopped blooding Ma Bo spore spreading in hemorrhage part.Yin Ma Bo can not be absorbed by tissue, therefore be not used in hemostasis in the tissue.
(chemical composition: fruit contains Arctiin to Fructus Arctii, and hydrolysis generates aretigenin and glucose.Contain again matairesinol, trachelospermum jasminoide aglycon, times hemilignin AL-D and AL-F.Seed contains Arctiin, arctigenin-4'-gentiobioside A, B, C, D, E, F, H; Fatty oil again, wherein fatty acid composition has: arachidic acid, stearic acid, Palmic acid and linoleic acid etc.)
The property of medicine: acrid in the mouth, hardship, cold nature.
Pharmacological property: 1, resisting pathogenic microbes effect Fructus Arctii water logging agent to Pilus Caprae seu Ovis sample microspore tinea bacterium, Trichophyton concentricunm, trichophyton, permitted the dermatophytes such as Lan Shi achorion, Microsporon audouini, rust microspore's tinea bacterium, epidermophyton inguinale, epidermophyton rubrum, star nocardia and staphylococcus aureus in various degree inhibitory action all arranged.There is the activity of anti-HIV in Fructus Arctii extract.
2, on immunologic function affect Fructus Arctii extract can enhancing human body immunity function, can significantly improve mouse lymphocyte conversion ratio and α-naphthyl acetate esterase positive rate, and can increase the antibody-producting cell number, strengthen cytophagous phagocytic function.
3, renal effect aretigenin lumbar injection is improved effect to the adriamycin-induced nephropathy in Wistar rats due to the aminonucleoside, can suppresses the increase of urinary protein excretion, and can improve Biochemical Indices In Serum.Oral administration can improve urine protein, and the N-acetyl-β during intravenous injection can suppress to urinate-glucamine acyl enzymatic activity and urine amount increase.
(chemical composition: fruit contains the iridoid constituents to Fructus Gardeniae: jasminoidin; square rafter glycosides all; square rafter element-1-gentiobioside with cape jasmines all, Fructus Gardeniae glycosides, Fructus Gardeniae ketoside; Herba Paederiae time glycosides methyl ester; all sweet acid of square rafter, deacetylate asperuloside acid, deacetyl asperulosidic acid methyl ester; the 10-acetyl group is square rafter glycosides all, 6 "-p-coumaroyl plain gentiobioside with cape jasmine of square rafter all.Still contain the acids composition: chlorogenic acid, 3,4-, two-O-caffeoyl quinic acid; 3-O-coffee acyl-4-O-mustard acyl quininic acid, 3,5-, two-O-coffee acyl-4-O-(3-hydroxy-3-methyl) glutaryl quininic acid; 3,4-, two coffee acyls-5-(3-hydroxy-3-methyl glutaryl base) quininic acid, crocetin; crocin, ursolic acid, crocin glucose glucosides etc.; also contain flavones ingredient: rutin, PEARLITOL 25C, cupreol; choline, nonacosane and phylloxanthin etc.)
The property of medicine: bitter in the mouth, cold in nature.
Pharmacological property: 1, calm, analgesic, analgesic activity Fructus Gardeniae alcohol extract can reduce spontaneous activity in mice to mouse peritoneal injection or gavage, has sedation, and significant prolongation hexobarbital length of one's sleep of receiving.Fructus Gardeniae and different processed product alcohol extract all have refrigeration function, and be the strongest to give birth to the product refrigeration function.Fructus Gardeniae water extract, jasminoidin, geniposide etc. can suppress the mouse writhing reaction that lumbar injection acetic acid causes, analgesic activity is arranged.
2, the ethyl acetate of antiinflammatory action Fructus Gardeniae alcohol extract dissolving part, dissolve with methanol part and water-soluble part xylol and Oleum Tiglii causes mice auricle swelling, formaldehyde causes the subacute ankle swelling of rat that obvious inhibitory action is all arranged.
3, the effect Fructus Gardeniae water extract of resisting pathogenic microbes and alcohol extract have inhibitory action to staphylococcus aureus, meningococcus, micrococcus catarrhalis, diphtheria corynebacterium, Bacillus typhi and various skin fungus, and can kill leptospira and imago of blood fluke, suppress the propagation of cells of coxsackie B 3 virus, have the activity of certain anti-simian immunodeficiency virus.
(chemical composition: Bombyx Batryticatus contains protein to Bombyx Batryticatus, ammonium oxalate, 17 seed amino acids such as lysine, leucine, aspartic acid, 28 kinds of elements such as magnesium, calcium, zinc, and abnormal active stimulin, ecdysterone, 3-hydroxyl cynruin and 6-N-ethoxy adenine etc.）
The property of medicine: acrid in the mouth, salty, property is flat.
Pharmacological property: 1, central nervous system's the Bombyx Batryticatus that affects had hypnosis and anticonvulsant action.Bombyx Batryticatus alcohol water-leach liquor mice is subcutaneous, lumbar injection or gavage and the intravenous rabbit injection all has syngignoscism.The effect of its syngignoscism and subcutaneous injection phenobarbital is similar.Bombyx Batryticatus can reduce the death toll that the strychnine induced mice is fainted from fear.But the convulsions that galvanic shock, pentetrazole and caffeine are caused is without obvious antagonism.
2, the bacteriostasis Bombyx Batryticatus has weak bacteriostasis to staphylococcus aureus, escherichia coli, bacillus pyocyaneus.
(chemical composition: the rhizoma cimicifugae dahuricae rhizome contains ferulic acid to Rhizoma Cimicifugae, Hesperetic acid, caffeic acid, cimifugin, cimicifugoside, rhizoma cimicifugae dahuricae terpene, visnagin, nor-visnagin, visamminol, 12-hydroxyl Rhizoma Cimicifugae epoxy alcohol galactoside, cupreol, Rhizoma Cimicifugae epoxy alcohol, Rhizoma Cimicifugae epoxy alcohol xyloside, the glucosides and the indole ketone that also contain take Cimicifuga Dahurica alcohol as aglycon become to grade)
The property of medicine: acrid in the mouth, sweet, cold nature.
Pharmacological property: 1, antipyretic effect rhizoma cimicifugae dahuricae extract or its composition Hesperetic acid all can make the rat normal body temperature reduce, and the rat experiment heat pyrexia is also had refrigeration function.Rhizoma Cimicifugae or rhizoma cimicifugae dahuricae water extract have analgesic activity to mouse stomach.
2, the toes edema has inhibitory action due to antiinflammatory action rhizoma cimicifugae dahuricae and effective ingredient Hesperetic acid on Carrageenan or the dextran.Can make the rat gastric ulcer area reducing due to lactic acid or the acetic acid.
3, calm, anticonvulsant action Rhizoma Cimicifugae decoct can make the mice autonomic activities reduce, and presents sedation.The dahurinol extract has inhibitory action to fainting from fear due to Camphora or the strychnine.
4, on the affecting the Rhizoma Cimicifugae triterpenoid compound and can reduce lymphocytic activity of immunologic function, the lymphocyte transformation that ConA is induced has very strong inhibitory action.Cimigenol xyloside can suppress cellular uptake nucleotide by selectivity, suppresses lymphocyte transformation.And Rhizoma Cimicifugae water extract induction of lymphocyte produces IFN, and in the external lymphocyte transformation that can promote that phytohaemagglutinin or ConA induce.
5, spasmolysis rhizoma cimicifugae dahuricae methanolic extract can resist the contraction of the guinea pig in vitro jejunum that Ach, histamine, BaCL2 cause, the spasmolysis of its active component visamminol is 1/3 of papaverin hydrochloride.
Radix Isatidis (chemical composition: Isatis indigotica Fort. root: contain indigo, cupreol, clionasterol.And contain several amino acids: arginine, glutamic acid, tyrosine, proline, valine, γ-aminobutyric acid.Also contain the indigo glycosides, sinigrin, couroupitine A, 1-Hydrogen thiocyanate-2-hydroxyl fourth-3-alkene, table is accused Yichun, adenosine, Palmic acid, sucrose and proteoglycan.
Rhizoma Et Radix Baphicacanthis Cusiae: contain chrysophanol, the indigo glycosides, indirubin, indigo, cupreol, lupeol, betulin, lupenone.)
The property of medicine: bitter in the mouth, cold in nature.
Pharmacological property: 1, antibacterial action Radix Isatidis decoct experiment in vitro has inhibitory action to staphylococcus aureus, staphylococcus epidermidis.Radix Isatidis has the effect of the remarkable enterobacteria O111B4 of Chinese People's Anti-Japanese Military and Political College endotoxin.
2, immunoregulation effect Banlangen Polysaccharide lumbar injection can strengthen mice to the DTH of DNCB, the cell transformation of inductor endolymph and enhancing spleen nk cell activity.Can also promote immune function of mice, strengthen antibody forming cell's function, increase the mouse mainline carbon granule and clean up speed.
(chemical composition: mature peel contains volatile oil to Pericarpium Citri Reticulatae, and wherein main constituent is limonene, still contains beta-myrcene, α-and nopinene, α-and γ-terpinene, α-thujene, α-phellandrene, sabinene, octanal, cymol, α-ocimene, terpinolene, linalool, 3,7-dimethyl-7-octenal, the 4-terpineol, alpha-terpineol, capraldehyde, citronellol, α-farnesene, perillaldehyde, carvacrol, and benzyl alcohol, nerol, neral, capryl alcohol, thymol, citronellal, aquation sabinene etc.Contain again flavones ingredient: 5,7,4'-trimethoxyflavone, 5,7,8,4 '-tetramethoxy flavones, senensetin, Nobiletin, Su Daqi flavone, tangerine produced in fujian province element, xanthomicrol, and Hesperidin, neohesperidin, rice Fructus Citri tangerinae element, the nor-rice of 5-Fructus Citri tangerinae element etc.Also contain cupreol, limonin, ferulic acid etc.）
The property of medicine: acrid in the mouth, hardship, warm in nature.
Pharmacological property: 1, antiinflammatory immunity function Hesperidin and hesperidin methyl have the effect of Citrin sample, and can resist the caused capillary permeability of kistrin and LYSOLECITHIN SUNLECITHIN A increases.The cutaneous permeability that hesperidin methyl causes chloroform increases also inhibitory action.Hesperidin has inhibitory action to rat Fructus Crotonis oleogranuloma.Nobiletin can significantly resist isolated ileum segments in guinea pigs and the bronchial anaphylaxis of Ovum Gallus domesticus album sensitization and shrink.Oral Hesperidin has inhibitory action to perfecting the rat response to passive immunization, and can suppress the abdominal cavity histamine release of mast cell.Therefore think that Hesperidin is the effective ingredient of resisting I-type allergic reaction.Pericarpium Citri tangerinae water decoction-alcohol sedimentation injection subcutaneous injection all has remarkable potentiation, but the T lymhocyte transformation rate is had obvious inhibitory action guinea pig serum lysozyme content, serum coagulation antibody titre, cardiac blood T lymphocyte E rosette forming rate.
Make medicine: Radix Glycyrrhizae (the chemical composition Radix Glycyrrhizae: root and rhizome master contain triterpene saponin, wherein main a kind of be glycyrrhizin, be potassium salt and the calcium salt of glycyrrhizic acid.Other triterpene saponin has: Glycyrrhiza uralensis Fisch. saponin A, B and glycyrrhizin A3, B2, C2, D3, E2, F3, G2, H2, J2, K2.Contain again the flavone compounds, such as 4',7-Dihydroxyflavanone, liquirtin, isoliquiritin unit, isoliquiritin, Neoliquiritin, Neoisoliquiritin, licoricidin (+)-Licoricidin., Licoricone, formoononetin, puriri glycosides II, ononin, Isolicoflavonol..Also contain the Coumarins chemical compound, such as the Radix Glycyrrhizae coumarin, glycyol, isoglycyol, Radix Glycyrrhizae coumarin-7-methyl ether, neoglycyrol, Radix Glycyrrhizae pyrans coumarin, licocoumarone etc.Contain again alkaloid, such as 5,6,7,8-tetrahydrochysene-4-methylquinoline, 3-methyl-6,7,8-three hydrogen pyrrolo-es (1,2-a) pyrimidine-3-ketone.Also contain licobenzofuran, cupreol, n-tricosanes etc., other contains Angelica Polysaccharide UA, UB, the UC of the tool RE activity of 3 kinds of neutrality of Radix Glycyrrhizae glucosan, polysaccharide GR-2 II a, GR-2 II b, GR-2 II c and the polysaccharide GPS etc. of multiple tool immunologic enhancement.）
The property of medicine: sweet in the mouth, property is flat.
Pharmacological property: 1, antiinflammatory action liquorice beverage extractum subcutaneous injection can resist auricle edema and the acetic acid twisting reaction that Oleum Tiglii brings out, and the chronic inflammatory disease of granulation tissue hyperplasia is also had obvious inhibitory action.The main component of Radix Glycyrrhizae antiinflammatory is glycyrrhizin and enoxolone, and licoflavone, zinc glycyrrhizate, Licochalcone A etc. also have certain effect.
2, resisting pathogenic microbes effect glycyrrhizin, Radix Glycyrrhizae phenols, chalcone derivative, glycyrrhizin, licoflavone etc. have the effect of anti-HIV in various degree, and are especially the most obvious with the licoflavone effect.Angelica Polysaccharide, glycyrrhizic acid, enoxolone, glycyrrhizin have inhibitory action to vesicular stomatitis virus, adenovirus, herpes simplex virus, vaccinia virus, varicella zoster virus, influenza A virus etc. respectively.FM100, Monosodium glycyrrhetin, enoxolone etc. all have inhibitory action to golden yellow glucose coccus, tubercule bacillus, escherichia coli, ameba and infusorian etc.
3, to 1. anti-allergic effects of immune effect: Radix Glycyrrhizae extract has preferably anti-allergic effects, can obviously reduce the incidence rate of anaphylactic shock guinea-pigs.The glycyrrhizin lumbar injection also has stronger anti-allergic effects.2. on the impact of nonspecific immunity: Radix Glycyrrhizae, Radix Glycyrrhizae (processed with honey), glycyrrhizin can significantly improve the mice carbon granule and clean up index, stimulate cytophagous phagocytosis.The liquorice beverage decoct of doses is dual regulation to the function of macrophage, can promote phagocytic function under stress state, and shows as inhibition rest state is next.Ammonium glycyrrhizinate can make the active significantly enhancing of NK cells in mice.3. on the impact of specific immunity: certain density glycyrrhizic acid can make antibody significantly increase.The generation of ammonium glycyrrhizinate antagonist has inhibitory action.Ammonium glycyrrhizinate also can significantly suppress the synthetic of lung and kidney PGE2, PGF2, makes the active significantly enhancing of NK cells in mice.Glycyrrhizin can improve the level of ConA induction of lymphocyte human spleen cell γ-IFN, strengthens the generation of ConA induction of lymphocyte secretion IFN, but the IFN level that phytohaemagglutinin is induced is without impact.Glycyrrhizin can also suppress complementary reaction.In a word, Radix Glycyrrhizae has dual regulation to immunomodulating, namely there is potentiation the reaction of antigen, again unusual immunoreation is inhibitory action.
(chemical composition Radix Panacis Quinquefolii master contains triterpene saponin to Radix Panacis Quinquefolii, having take oleanane as aglycon: ginsenoside-R0; Take 20(S) protopanoxadiol has as aglycon: ginsenoside-Rb1 ,-Rb2 ,-Rb3 ,-Rc ,-Rd ,-RAo ,-F2, malonyl ginsenoside-Rb1 ,-Rb2 ,-Rd, Radix Panacis Quinquefolii saponin-R1, gypenoside X, X I, VII; Take 20(S) Protopanaxatriol has as aglycon: panax saponin-Re ,-Rf ,-Rg1 ,-Rg2 ,-Rg3 ,-Rh1 ,-F3; Take omeprazole ladder alcohol having as aglycon: Panax pseudoginseng Wall. saponin F11.The total saponin content of wild species is 11.74%, cultigen be 7.06%.Contain again volatile oil, wherein main constituent is β-farnesene, and content can reach 26.45%, also contains capryl alcohol, acid, hendecane, 10-Pinen-3-ol is sad, dodecane, 3-hexane phenyl, 1-hexane phenyl, pulegone, Mentha piperita alkene, β-gurjunene, longifolene, α-curcumene, eneα-cedar, β-bisabolence, β-Flos Caryophylli alkene, 3-phenyl decane, hexadecane, 3,4,6-phenyl hendecane, 2,3,4,5,6-phenyl dodecane, 4,5-phenyl tridecane etc., also contain the polyacetylene constituents: sickleleaf celery alcohol, panaxytiol, panaxydol and polyacetylene PQ-1, PQ-2, PQ-3, PQ-4, PQ-5, PQ-6.From oils and fats, obtain in addition fatty acid composition: caproic acid, enanthic acid, sad, n-nonanoic acid, Palmic acid, n-heptadecane acid, n-octadecane acid, oleic acid, oleanolic acid, linolenic acid etc., wherein linolenic acid content accounts for 44.78% of total oil mass; Contain again phospholipid, what content was maximum is diphosphatidylglycerol, is phosphatidylcholine secondly, and the two closes and accounts for 88% of total amount, also contains LYSO-PHOSPHATIDYLCHOLINE LYSOPC, phosphatidylinositols etc.; Contain again saccharide, total amount reaches 68.2%-74.3%, in the panose is arranged, sorbose, fructose, glucose, sucrose, maltose; Other contains pectin 2.27%-3.98%, still contains several amino acids, such as aspartic acid, and threonine, serine, glutamic acid, glycine, methionine, TYR, lysine, arginine, proline etc., total amount is 11.70%, wherein essential amino acids is 6.97%; Also contain the Hu Luobu glycosides, stigmastenol, 3,5-bean steroid diene-3-ketone, vitamin A, B1, B2, B6, and the inorganic elements such as ferrum, aluminum, calcium, barium, ketone, manganese, phosphorus, strontium, titanium, zirconium, cadmium, chromium, nickel.）
The property of medicine: sweet in the mouth, little hardship, cool in nature.
Pharmacological property: 1, central nervous system's effect PQS can significantly suppress the spontaneous activity of mice, prolongs the pentobarbital sodium hypnosis time of sub-threshold dose, has sedation.Radix Panacis Quinquefolii has sedation to brain, and vital center is then had the moderate excitation.
2, affect the damage that Radix Panacis Quinquefolii or PBS can resist the mouse immune organ that cyclophosphamide causes to immune, can also promote the growth of young Mus thymus organ.PQS can work in coordination with in vivo and in vitro ConA and promote mouse boosting cell propagation; Collaborative ConA strengthens the ability that the mice splenic t-cell produces lymphokine; Obviously strengthen mice spleen NK cytoactive.PQS can also strengthen the breeder reaction that LPS stimulates mouse boosting cell in vivo; Strengthen mice to the primary antibody response ability of thymus dependent antigen.The American ginseng root crude polysaccharides can resist alleviating of immunologic hypofunction mouse peripheral blood leukopenia and Thymus and spleen weight, and can strengthen the phagocytic function of normal and immunologic hypofunction mice reticuloendothelial system, the simultaneously lymphocyte transformation of energy Promote immunity hypofunction mice.
(chemical composition: kernel contains nearly 30 kinds of volatile oil to Fructus Amomi, mainly contains acetyl borneol fat, Camphora, limonene, lauro lene, linalool, α-and nopinene, Borneolum Syntheticum, beta-elemene, β-Flos Caryophylli alkene, β-bergmot oil alkene, α-thujene, myrcene, α-phellandrene, α-farnesene, β-farnesene, β-bisabolence, γ-cadinene, Humuleno, Palmic acid etc.Fruit is various trace elements still, such as zinc, copper, ferrum, violent, cobalt, chromium, molybdenum, nickel, titanium, vanadium etc.）
The property of medicine: acrid in the mouth, warm in nature.
Pharmacological property: 1, can remove carbachol fully to the spasm effect of isolated rabbit intestinal to the neural main component Camphora 1:25000 that affects in the Fructus Amomi; Give mice 100mg/kg, can strengthen trembling due to the arecoline; 50mg/kg can prevent the spasm effect of nicotinamide.
2, other effect Fructus Amomis have remarkable inhibitory action to the reduction of the caused peripheral blood leucocyte of cyclophosphamide, erythrocyte, Hb value.Fructus Amomi has obvious analgesic activity, can also significantly reduce the mouse antibodies cell number.
The present invention is applicable to the drug of first choice that infects due to responsive G+ bacterium, G-coccus and the spirillum.
(1) streptococcal infection: such as cellulitis, pharyngitis, tonsillitis, scarlet fever, endocarditis etc.
(2) epidemic encephalitis: first-selected benzylpenicillin+sulfadiazine
(3) pneumococcal infection: lobar pneumonia, empyema, bronchitis
(4) spirochaete infection: leptospirosis, syphilis, relapsing fever
(5) actinobascillosis.
(6) tetanus, diphtheria: need to share with antitoxin
Most G+ coccuses: such as Hemolytic streptococcus, Streptococcus viridans, streptococcus pneumoniae does not produce enzyme staphylococcus etc.
G+ bacillus: diphtheria corynebacterium, anthrax bacillus, bacillus perfringens, clostridium tetani, lactobacillus etc.
G-coccus: Neisseria meningitidis, non-drug resistance Diplococcus gonorrhoeae.
Spirillum, Actinobacillus.
Claims (1)
1. stone cattle antipyretic oral liquid, it is characterized in that: it is processed by following Chinese medicine and water, and described Chinese medicine includes component, by percentage to the quality:
Gypsum Fibrosum 39% Cornu Bubali silk 6.5% Radix Scutellariae 3.25% Rhizoma Coptidis 3.25% Radix Scrophulariae 6.5% Radix Rehmanniae 6.5% Fructus Forsythiae 1.96% Radix Platycodonis 1.96% Radix Bupleuri 1.96% Lasiosphaera Seu Calvatia 1.96% Fructus Arctii 1.96% SHANZHIZI 1.96% Bombyx Batryticatus 0.67% Rhizoma Cimicifugae 0.67% Radix Isatidis 1.96% Pericarpium Citri Reticulatae 1.3% Radix Glycyrrhizae 1.3% Rhizoma Anemarrhenae 3.25% Cortex Moutan 2.17% Radix Paeoniae Rubra 2.17% bright Folium Bambusae 6.5% Radix Panacis Quinquefolii 2.17% Fructus Amomi 1.08%.
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| CN106692195A (en) * | 2016-12-28 | 2017-05-24 | 重庆金邦动物药业有限公司 | Florfenicol dry suspension agent and preparation method thereof |
| CN106539822A (en) * | 2016-12-29 | 2017-03-29 | 重庆金邦动物药业有限公司 | Florfenicol powder and preparation method thereof |
| CN111050556A (en) * | 2017-08-02 | 2020-04-21 | 诺瓦蒙特股份公司 | Herbicidal composition based on pelargonic and nonenoic acids |
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