CN114699467B - Traditional Chinese medicine for clearing lung and reducing fever and application thereof - Google Patents

Abstract

The invention discloses a lung-heat clearing and defervescing traditional Chinese medicine and application thereof in preparing medicines for treating acute upper respiratory tract infection, wherein the lung-heat clearing and defervescing traditional Chinese medicine is prepared from, by weight, 15-30 parts of wild buckwheat rhizome, 9-15 parts of stir-fried baikal skullcap root, 4-9 parts of perilla leaf, 4-9 parts of peppermint, 4-9 parts of radix peucedani, 4-9 parts of radix bupleuri, 15-30 parts of sweet wormwood herb, 15-30 parts of dyers woad leaf, 4-9 parts of blackberry lily, 4-12 parts of platycodon root, 4-12 parts of white mulberry root-bark, 4-12 parts of fritillary bulb, 4-15 parts of dahurian angelica root and 9-15 parts of medicated leaven. The traditional Chinese medicine composition is used for treating acute upper respiratory tract infection, can obviously accelerate the alleviation of symptoms such as fever and the like, and promotes the recovery of diseases; the traditional Chinese medicine has the effects of clearing lung, bringing down fever and the like, and has reliable curative effect; the raw materials are easy to obtain, the price is low, the preparation is convenient, and the application range is wide.

Description

Traditional Chinese medicine for clearing lung and reducing fever and application thereof

Technical Field

The invention relates to the field of traditional Chinese medicine formulas for treating fever, in particular to a traditional Chinese medicine formula granule composition for treating patients with acute upper respiratory tract infection of 10 years old and older.

Background

Acute upper respiratory tract infection is a general expression of acute inflammation of nasal cavity, pharynx or larynx caused by virus or bacteria, often commonly called virus, is the most common infectious disease of respiratory tract, has stronger infectivity and can cause serious complications. The related literature shows that the infection caused by viruses accounts for 70% -80%, bacterial infection such as influenza virus (A, B and C), rhinovirus, parainfluenza virus, respiratory syncytial virus, adenovirus, epstein-Barr virus, measles virus, rubella virus and the like can be directly or secondarily caused by the virus infection, and hemolytic streptococcus is used as a common part, and the other parts are haemophilus influenzae, streptococcus pneumoniae, staphylococcus, mycoplasma, chlamydia and the like, and even gram negative bacillus divides rhinitis pharyngolaryngitis or tonsillitis according to the infection part

The disease is caused by the reasons of catching cold, rain, overfatigue and the like, the body has reduced defending function, or the body lacks immunity virus or bacteria to the mutated virus, can be rapidly propagated locally, and is especially more easily caused by the old, young, weak or chronic respiratory diseases, thus being the main cause of recurrent attacks of chronic bronchitis.

Symptoms such as fever, cough, pharyngalgia, nasal obstruction, running nose, headache, hypodynamia, aversion to cold and the like in the acute stage often affect the life of patients, and no ideal antiviral drugs and long-term effective antibacterial drugs are available in Western medicine so far, and symptomatic treatment is often mainly carried out.

Disclosure of Invention

The invention aims to provide a lung-heat clearing and defervescing traditional Chinese medicine formula granule composition capable of obtaining effective, obvious, sustained and stable treatment results for acute upper respiratory tract infection and application thereof.

The traditional Chinese medicine formula particle composition is used for treating acute upper respiratory tract infection, can obviously accelerate the alleviation of symptoms such as fever and the like, and promotes the recovery of diseases; the traditional Chinese medicine has the effects of clearing lung, bringing down fever and the like, and has reliable curative effect; the raw materials are easy to obtain, the price is low, the preparation is convenient, and the application range is wide.

In order to solve the problems, the invention adopts the following technical scheme:

The traditional Chinese medicine formula granule composition for clearing lung and reducing fever comprises, by weight, 15-30 parts of wild buckwheat rhizome, 9-15 parts of stir-fried baikal skullcap root, 4-9 parts of perilla leaf, 4-9 parts of peppermint, 4-9 parts of bupleurum chinense, 15-30 parts of sweet wormwood and 15-30 parts of dyers woad leaf. (the pharmaceutical formulation is a basic formulation for treating patients with acute upper respiratory tract infections).

The traditional Chinese medicine formula granule composition for treating acute upper respiratory tract infection comprises, by weight, 15-30 parts of wild buckwheat rhizome, 9-15 parts of stir-fried baikal skullcap root, 4-9 parts of perilla leaf, 4-9 parts of peppermint, 4-9 parts of radix bupleuri, 15-30 parts of sweet wormwood, 15-30 parts of dyers woad leaf, 4-9 parts of blackberry lily, 4-12 parts of platycodon root, 4-12 parts of white mulberry root-bark and 4-12 parts of thunberg fritillary bulb. (the medicine formula is mainly used for treating wind-cold type heat dissipation and phlegm-dampness obstructing the lung of patients suffering from acute upper respiratory tract infection).

The traditional Chinese medicine formula granule composition for treating acute upper respiratory tract infection comprises, by weight, 15-30 parts of wild buckwheat rhizome, 9-15 parts of stir-fried baikal skullcap root, 4-9 parts of perilla leaf, 4-9 parts of peppermint, 4-9 parts of radix bupleuri, 15-30 parts of sweet wormwood, 15-30 parts of dyers woad leaf and 4-15 parts of radix angelicae. (the medicine formula is mainly used for treating patients with acute upper respiratory tract infection which are attacked by wind-heat).

The traditional Chinese medicine formula granule composition for treating acute upper respiratory tract infection comprises, by weight, 15-30 parts of wild buckwheat rhizome, 9-15 parts of stir-fried baikal skullcap root, 4-9 parts of perilla leaf, 4-9 parts of peppermint, 4-9 parts of radix bupleuri, 15-30 parts of sweet wormwood, 15-30 parts of dyers woad leaf, 9-15 parts of medicated leaven, 9-15 parts of stir-fried malt and 9-15 parts of scorched hawthorn fruit. (the medicine formula is mainly used for treating wind-cold heat, acute upper respiratory tract infection patients with lung and stomach imbalance).

The traditional Chinese medicine formula particle composition for treating acute upper respiratory tract infection is composed of, by weight, 15-30 parts of wild buckwheat rhizome, 9-15 parts of stir-fried baical skullcap root, 4-9 parts of perilla leaf, 4-9 parts of mint, 4-9 parts of radix peucedani, 4-9 parts of north bupleurum, 15-30 parts of sweet wormwood, 15-30 parts of dyers woad leaf, 4-9 parts of blackberry lily, 4-12 parts of platycodon root, 4-12 parts of white mulberry root-bark, 4-12 parts of fritillary bulb, 4-15 parts of dahurian angelica root and 9-15 parts of medicated leaven (the medicine formula is mainly used for treating wind-cold type heat, phlegm-dampness and lung-stomach imbalance acute upper respiratory tract infection patients). Further preferably, 15 parts of stir-fried baical skullcap root, 9 parts of perilla leaf, 30 parts of dyers woad leaf, 9 parts of mint, 12 parts of platycodon grandiflorum, 9 parts of radix peucedani, 9 parts of radix bupleuri, 12 parts of white mulberry root-bark, 12 parts of thunberg fritillary bulb, 15 parts of dahurian angelica root, 15 parts of medicated leaven (namely, charred medicated leaven), 30 parts of sweet wormwood, 30 parts of wild buckwheat rhizome and 9 parts of blackberry lily.

The invention relates to a traditional Chinese medicine formula granule composition for treating acute upper respiratory tract infection, which comprises the following components: the traditional Chinese medicine formula granule composition for treating acute upper respiratory tract infection provided by the invention can be prepared for 1 person, is divided into 2 bags by taking g as a unit and 1 dose per day, and is taken 1 time according to the conventional traditional Chinese medicine formula granule, 100-200 ml of warm boiled water is taken each time, and 1 time in the morning and evening. The traditional Chinese medicine formula particle composition for treating acute upper respiratory tract infection provided by the invention can be prepared for a plurality of people, wherein the gram (g) is taken as a unit, the quantity of 1 person in the formula is multiplied by the number of people who need to take the formula particles, the corresponding needed traditional Chinese medicine formula particles are taken for brewing, the juice quantity is multiplied by the needed quantity of each person, and the traditional Chinese medicine formula particle composition for treating acute upper respiratory tract infection is taken for 1 time in the morning and evening.

Pharmacological actions of various crude drugs of the invention:

wild buckwheat rhizome:

it is slightly pungent and astringent in flavor, cool in nature and enters lung meridian. The product has effects of clearing heat and detoxicating, detumescence and relieving sore throat, and dispelling pathogenic wind and dampness. It is used for treating cough due to lung heat, lung abscess with purulent phlegm, sore throat, stomach ache, dyspepsia, dysentery, common cold, rheumatalgia, traumatic injury, lumbago, skelalgia, sore, carbuncle, swelling and toxin, insect poison, and rabies bite. The product contains wild buckwheat glycoside, and can be hydrolyzed to obtain coumaric acid, ferulic acid and glucose. Each part contains flavone components such as rutin, and leaves and fruits contain flavone components such as rutin, procyanidin, and the like, and also contains polyprocyanidin, hecogenin, beta-sitosterol, and the like. In addition, contains effective components such as tannins, volatile oil, etc. The product has pharmacological actions: 1. antibacterial action: jin Yang the extract of the wheat can obviously inhibit the activity of extracellular heat-resistant nuclease of staphylococcus aureus, escherichia coli, bacillus subtilis, bacillus thuringiensis and double-coccus kara, and has obvious antibacterial effects on fungi such as flagella, candida albicans and the like; 2. antitussive, expectorant, and antiinflammatory effects: the rhizoma Fagopyri Dibotryis extract has antitussive, expectorant and antiinflammatory effects; 3. antitumor effect: the wild buckwheat rhizome extract has obvious anti-tumor effect, and in-vitro cell direct killing method experiments prove that the wild buckwheat rhizome extract has obvious killing effect on lung adenocarcinoma cells (GLC), cervical squamous carcinoma cells (HeLa), gastric adenocarcinoma cells (SGC-7901), nasopharyngeal squamous carcinoma cells (KB) and other human cancer cells, and the killing effect and the inhibiting effect are obviously enhanced along with the increase of the mass concentration of the medicine. The wild buckwheat rhizome has the effects of obviously killing various human cancer cells, inhibiting the growth and proliferation of stem cells and inhibiting DNA synthesis, and the wild buckwheat rhizome extract can obviously inhibit the nucleic acid metabolism in the cancer cells, and the inhibition effect is similar to that of positive control fluorouracil with the same mass concentration; DFr4 and CTX combined application plays a role in adding the inhibition of the growth of the transplanted tumor S180 and the liver cancer H22, and can antagonize the bone marrow inhibition caused by CTX; 4. antioxidant effect: diboside A and lapath oside A separated from rhizoma Fagopyri Dibotryis have weak antioxidant effect, and 70% ethanol extract of rhizoma Fagopyri Dibotryis has in vitro lipid peroxidation resisting effect; 5. enhancing immune function: the wild buckwheat rhizome drug-containing serum has obvious quantitative effect and time effect relationship on the proliferation activity of chicken spleen lymphocytes; 6. h1 receptor blocking: the wild buckwheat rhizome tablet (wild buckwheat rhizome extract) can resist the isolated guinea pig ileum muscle contraction reaction caused by histamine, and has obvious dose-effect and aging relation; 7. Inhibiting platelet aggregation: in vitro flavanol can inhibit ADP and Staphylococcus aureus induced platelet aggregation in rats, and the action intensity is enhanced with the dosage.

Blackberry lily:

it is bitter and pungent in flavor, cold in nature, and enters lung, liver and spleen meridians. The product has effects of clearing heat and detoxicating, clearing lung-heat and eliminating phlegm, and dispelling blood and detumescence, and is mainly used for treating phlegm fire stagnation, laryngopharynx swelling and pain, phlegm cough and asthma etc. caused by heat toxin, and can be widely used for clinical upper respiratory tract infection, suppurative tonsillitis etc. The product contains flavonoids, isoflavone and its derivatives, ketones, phenols, benzoquinone, bicyclic triterpenes, steroids and volatile components. Wherein the isoflavone compound is irisin, tectorigenin, genistein, dimethyl tectorigenin, sub-tectorigenin, tectorigenin A, tectorigenin B, tectorigenin, 6 '-O-vanillin-wild tectorigenin, 2, 3-dihydro-wild tectorigenin, 6' -D-p-hydroxybenzoyl wild tectorigenin, wild tectorigenin, white tectorigenin, 5,7,3 '-trihydroxy-8, 4' -dimethoxy isoflavone, demethyl wild tectorigenin A. The flavonols include isorhamnetin and 3' -O-methyl rhamnetin. Triterpene fatty acids, etc. The product has pharmacological actions: 1. anti-inflammatory action and anti-tumor Activity: tectorigenin and tectoridin both inhibit prostaglandin E2 production in rat peritoneal macrophages induced by protein kinase C activator, 12-O-tetradecanoyl crotyl alcohol-13-acetate (TPA) or endomembrane Ca2+ -ATPase inhibitor; 2. scavenging free radical action: wild tectorigenin, tectorigenin and 5,6,7,4' -tetrahydroxy-8-methoxyisoflavone all have the function of scavenging free radicals; 3. estrogenic effects: tectorigenin and wild tectorigenin (50-100. Mu. Mol/L) are effective in reducing the cell number of these 3 cell lines. Two phytoestrogens inhibit proliferation of cancer cells by regulating cell cycle, thereby reducing the number of prostate cancer cells; 4. antioxidant and anti-hepatotoxic effects: tectoridin and aglycone thereof can remarkably reduce serum transaminase activity increased due to liver injury, and can greatly enhance the activities of antioxidant enzymes such as superoxide dismutase, catalase and glutathione peroxidase in liver cell fluid. Tectoridin and aglycone thereof have antioxidant effect and liver protecting effect; 5. Antibacterial action: the blackberry lily has a strong inhibition effect on the multi-drug resistant strain; 6. effects on digestive system and experimental thrombus: the blackberry lily 75% ethanol extract 5 and 15g/kg can inhibit the formation of mouse indometacin-ethanol gastric ulcer, and has only a trend of inhibiting the formation of hydrochloric acid and water-logging stress gastric ulcer; 7. toxic fish activity: both n-hexane and ether extracts showed toxic fish activity and they were found to have cytotoxic effects on P388 lymphocytes, but most of the single ring iris compounds did not show toxic fish activity.

Parching Scutellariae radix:

it is bitter in taste and cold in nature, enters spleen, lung, small intestine, gallbladder and large intestine meridians. The product has effects of clearing heat, eliminating dampness, purging pathogenic fire, removing toxic substances, stopping bleeding, and preventing miscarriage. Is commonly used for treating fever, chest distress, thirst, damp-heat diarrhea and jaundice; cough, dry cough with little phlegm, asthma, etc. caused by lung heat; epistaxis, hematemesis, hemoptysis, and hematemesis due to blood heat. The product mainly contains flavonoid components such as baicalin, baicalein (baicalein), wogonin, and baicalein. Also contains volatile oil components such as acetophenone, palmitic acid, oleic acid, etc., beta-sitosterol, and baicalein. The product has pharmacological actions: 1. antibacterial action: the baikal skullcap root decoction has inhibiting effect on staphylococcus aureus, hemolytic streptococcus, pneumococcus and other gram positive bacteria, colibacillus, dysentery bacillus, pseudomonas aeruginosa and other gram negative bacteria in vitro; 2. antiviral action: the radix Scutellariae decoction and water extract have inhibitory effect on influenza A virus and hepatitis B virus in vitro; 3. antiallergic effect: baicalin and baicalein have inhibiting effect on acute and chronic inflammation, and can reduce permeability of capillary vessel and reduce release of anaphylaxis medium; 4. antipyretic effect: baicalin, total flavonoids of radix scutellariae and the like have obvious antipyretic effect; 5. antidepressant effect: the radix Scutellariae aqueous extract can improve depression symptoms by reducing inflammatory cytokine level and regulating neurogenesis pathway; 6. anticancer effect: baicalin induces apoptosis of colon cancer cells and inhibits tumor growth by reducing expression of c-Myc (protooncogene) and onconirs (RNA molecules affecting energy supply of cancer cells).

Perilla leaf:

this herb is pungent in flavor, slightly warm in nature, nontoxic, and enters spleen and lung meridians. The product has effects of relieving exterior syndrome, dispelling cold, activating qi-flowing and regulating stomach, and can be used for treating common cold due to wind-cold, cough and emesis, vomiting of pregnancy, and poisoning of fish and crab. The product contains volatile oil, flavone and anthocyanin, phenolic acids, glycosides, triterpenes and steroids. Wherein the volatile oil comprises linalool, linalyl acetate, neryl acetate, geranyl acetate, citral, geranial, vanillyl alcohol, stachyone, iso-stachyone, perillyl ketone, perillyl alkene and elsholtzia ketone, menthane (menthane) L-limonene, gamma terpinene, iso-terpinene, terpinene acetate. The aromatic components include methyl eugenol, apigenin, myristyl ether, asarone, dill oleoyl, safrole, styrene, dimethyl phthalate and 1, 3-dimethyl benzene, and the aliphatic components include neophytadiene, 7-octene-4-alcohol and jasmone. The flavonoid component comprises apigenin, apigenin-7-glucoside, apigenin-7-O-diglucoside, apigenin-7-caffeoyl glucoside, luteolin-7-glucoside, luteolin-7-O-diglucoside, luteolin-7-caffeoyl glucoside, chrysoeriol, high baicalein-7-O-diglucoside, scutellarin and baicalein-7-methyl ether. The anthocyanin comprises pelargonidin, cyanidin, paeoniflorin-3-glucoside, paeoniflorin-3- (6' -acetyl) glucoside, caffeoyl anthocyanin, perillanine, cis-perillanine, malonic acid single acyl-cis-perillanine. Phenolic acid components are classified into rosmarinic acid and cinnamic acid derivatives. Glycoside compounds including monoterpene glycoside, phenylpropanoid glycoside, cyanoside, elder glycoside, alcohol glycoside, phenylpentanoic acid-3-beta-D-glucopyranoside, and carrot glycoside. Triterpenes and steroid compounds, including oleanane (oleanane) triterpenes, bearberry alkane triterpenes and sterols. The product has pharmacological actions: 1. protecting cardiovascular and cerebrovascular systems, perillae herba can inhibit platelet aggregation, nourish myocardium, increase coronary artery blood flow, perillaldehyde can dilate rat arterial blood vessel, linolenic acid can resist thrombosis, and Perillae herba essential oil has effect in relieving focal cerebral ischemia injury of mice; 2. the flavonoids can effectively remove oxygen free radicals, the rosmarinic acid can effectively remove superoxide, and the perilla extract has the effect of preventing lipid peroxidation. Perilla extract has wide antibacterial activity, and it is presumed that its antibacterial active ingredient may exist in flavone, volatile oil, organic acid, phenol, etc. The perilla essential oil can inhibit the growth of bacteria to a certain extent, and can completely kill the bacteria when the concentration is high enough; 3. reducing blood lipid and blood sugar: purple Su Zifu contains alpha-linolenic acid, has the effects of reducing blood fat and blood pressure, and arachidonic acid in platelets can be converted into thromboxane and prostacyclin under the action of cyclooxygenase, and alpha-linolenic acid in purple perilla can reduce the level of arachidonic acid so as to play an antithrombotic role.

Peppermint:

it is pungent in flavor and cool in nature, entering lung and liver meridians. The product has effects of dispelling pathogenic wind and heat, clearing head and eyes, relieving sore throat, promoting eruption, dispersing stagnated liver qi, and activating qi-flowing. It is mainly used for treating wind-heat, headache, laryngopharynx swelling and pain, food stagnation and flatulence, aphtha, toothache, sore and scabies, urticaria, epidemic febrile at the beginning of epidemic febrile disease, pruritis, liver depression and qi stagnation, chest distress and hypochondriac pain. The product contains volatile oil, flavonoids, amino acids, organic acids, terpenes, and quinones. Wherein the volatile oil contains sesquiterpene volatile components such as L-menthol, isopulegol, L-mentha, and pulegone. The flavonoids include luteolin-7-glucoside, locust bean gum-7-O-neohesperidin, isoflavone glycoside, isoraffinyl, hesperidin, geraniin-7-O-glucoside, beta-daucosterol, etc. Amino acids include lysine, histidine, tyrosine, valine, arginine, aspartic acid, etc. The organic acid component includes: rosmarinic acid, caffeic acid, benzoic acid, trans cinnamic acid, and the like. Terpenes are classified into pentacyclic triterpenes and monocyclic monoterpenes. The quinones include emodin, chrysophanol, physcion, aloe-emodin, ursolic acid, daucosterol, trans cinnamic acid, benzoic acid, and beta-Gu You alcohol. Pharmacological action of the product: 1. acting on the central nervous system: the peppermint essential oil can regulate and control the content of amino acid neurotransmitters in brain areas related to mental fatigue by using smell. Menthol can block sodium ion inflow, thereby generating local nerve block and playing an analgesic role; 2. antiviral and antibacterial effects: the peppermint polysaccharide and the peppermint oil have strong inhibition effect on respiratory syncytial virus and also have strong inhibition effect on herpes simplex virus. The herba Menthae decoction can be used for resisting Staphylococcus epidermidis, staphylococcus aureus, proteus, pseudomonas aeruginosa, escherichia coli, streptococcus pneumoniae, etc. Peppermint oil also has fungicidal activity; 3. action on the digestive system: menthol and menthone have cholagogic effect; 4. action on respiratory system: menthol can increase secretion of respiratory tract mucus, reduce foam sputum of respiratory tract, reduce secretion weight, increase effective ventilation cavity, and dilute thick mucus for easy discharge; 5. local anesthetic action: menthol and menthone both have skin irritation. Menthone has local anesthetic and analgesic effects, and is more irritating to skin than menthol, and antiseptic in ethanol solution.

Radix Platycodi:

it is bitter and pungent in flavor, neutral in nature, and enters lung meridian. The product has effects of dispersing lung qi, relieving sore throat, eliminating phlegm, and expelling pus. Is mainly suitable for cough with excessive phlegm, chest distress, sore throat, hoarseness, pulmonary abscess and vomiting pus. The product mainly contains saponins, flavonoids, polysaccharides, fatty acids, and inorganic elements. Wherein the saponins include oleanolic acid type pentacyclic triterpene saponin, platycodin (platycodin A) and mandelic acid (platycodin B), and platycodin D. Flavonoid compounds mainly include flavanone, flavone and flavonoid glycoside compounds. The polysaccharide comprises platycodon grandiflorum GF 2-GF and inulin. Fatty oil fatty acids include linoleic acid, palmitic acid, linolenic acid and stearic acid, oleic acid, and brown resting acid among fatty acids. The radix Platycodi contains inorganic elements such as Fe, mn, co, zn, cr, mg, ca, sr, li. Pharmacological action of the product: 1. cough and asthma relieving: the platycodon grandiflorum water extract achieves the purpose of eliminating phlegm by increasing the secretion of the mucous membrane of the respiratory tract. The platycodon grandiflorum has a promoting effect on the release of LXA4 from asthmatic guinea pigs, can promote the secretion of IFN-gamma, and indirectly plays a role in regulating Th1/Th2 balance; meanwhile, the generation and release of oxygen free radicals can be reduced; 2. anti-inflammatory and antibacterial effects: with the increase of the concentration of the platycodin D, the change of the candida albicans from spore phase to mycelium phase is gradually reduced, and the adhesion number and the bacterial activity of the candida albicans are gradually reduced; 3. antitumor effect: platycodin D, platycodin D3 and polygalasaponin D can inhibit proliferation of human liver cancer Bel-7402 cell lines, human gastric cancer BGC-823 cell lines and human breast cancer MCF-7 cell lines, wherein platycodin D has the strongest inhibition effect; 4. hypoglycemic effect: the platycodon grandiflorum polysaccharide can also improve the activity of superoxide dismutase of liver tissues, reduce the content of malondialdehyde, improve the fasting insulin level and improve the antioxidant capacity; 5. antioxidant effect: the total platycodin and platycodin D have better capability of scavenging free radicals in vitro and have stronger activity than ascorbic acid with the same concentration; 6. liver protection effect: the platycodin substance has better protection effect on liver injury, and platycodin D has the effect of resisting liver fibrosis, and the effect of resisting liver fibrosis is achieved by inhibiting cell proliferation and activation of hepatic stellate cells, down regulating the expression level of hepatic tissue transforming growth factor-beta 1 (TGF-beta 1) and increasing the expression level of bone morphogenetic protein-7 (BMP-7).

Radix peucedani:

it is bitter and pungent in flavor, slightly cold in nature, and enters lung meridian. The product has effects of reducing qi and phlegm, dispelling pathogenic wind and clearing heat. It is indicated for dyspnea due to phlegm-heat, yellow and thick phlegm, cough due to wind-heat and excessive phlegm. The product mainly contains coumarin, inorganic element, volatile oil, etc. Wherein the coumarin is peucedanum praeruptorum first, peucedanum praeruptorum first Hu Dingsu, peucedanum praeruptorum first E, bergapten, palmitic acid, imperatorin, tetracosanoic acid, 2, 6-dimethylquinoline, and daucosterol; inorganic elements include phosphorus, sulfur, silicon, barium, aluminum, chromium, zinc, manganese, rubidium, selenium, chromium, titanium, iron, palladium, cerium, zirconium, lanthanum, copper, tin, nickel, cesium, vanadium, yttrium, niobium, and the like; the volatile oils are respectively beta-elemene, vanillin, beta-biotene, alpha-farnesene and the like; the other components include tanshinone IIA and tanshinone, daucosterol, peucedanin, tetracosanoic acid and palmitic acid. The product has pharmacological actions: 1. anti-myocardial ischemia and myocardial protecting effects: the pre-white flower Hu Diqu liquid can regulate the expression of myocardial apoptosis related genes caused by abdominal aortic constriction, so as to inhibit myocardial remodeling and exert biological treatment effect on heart failure; 2. improving cardiac function: the white flower front Hu Diqu liquid can effectively improve the left ventricle comfort function of a patient, improve the blood supply of the organism and relieve the heart failure symptom; 3. dilating blood vessel, lowering blood pressure: pra-C can inhibit smooth muscle cell proliferation caused by angiotensin II, reduce [ Ca2+ ] in vascular smooth muscle cells, and restore abnormal response of blood vessels to voltage-dependent and receptor-operated calcium channel agonists. Improving vascular hyperplasia and hypertrophy in terms of reducing smooth muscle cell area, reducing collagen content, reducing [ Ca < 2+ > ] and increasing NO release, and the like, thereby treating spontaneous hypertension; 4. antioxidant effect: coumarin (TCP) in peucedanum praeruptorum dunn can obviously inhibit the generation of mouse liver homogenate Malondialdehyde (MDA), and the TCP is suggested to effectively inhibit lipid peroxidation; 5. phlegm eliminating effect: the peucedanin and the violaxoside can enhance the tracheal excretion of phenol red of mice, and have the function of eliminating phlegm; 6. antibacterial action: the volatile oil component in the peucedanum praeruptorum dunn has a certain antibacterial activity on escherichia coli, salmonella typhi and shigella flexneri.

Radix bupleuri:

it is bitter in flavor, cool in nature, entering heart, liver and spleen meridians. It has effects of relieving exterior syndrome, relieving fever, dispersing stagnated liver qi, relieving qi stagnation, and raising yang qi. Is mainly used for treating exogenous fever, cold and heat, malaria, liver Yu Xie pain and distention, headache and dizziness, irregular menstruation, rectocele due to qi deficiency and sinking, uterine prolapse and gastroptosis. The product mainly contains triterpene saponins, volatile oils, flavonoids, polysaccharides, etc. Triterpene saponins: saikosaponin is one of the main components of bupleurum chinense and also one of the important activities of bupleurum chinense. The Saikosaponin separated so far is oleanane type derivative, comprises Saikosaponin (Saikosaponin-nin) a, d, c, S1, b2, v-2, 1, t, b3, f, q-1, q-2,2 '-O-acetyl Saikosaponin a, 2' -O-acetyl Saikosaponin b2 3 '-O-acetylsaikosaponin b2, 3' -O-acetylsaikosaponin d [ 9-14 ], saikosaponin v-1, 6 '-O-acetylsaikosaponin b2, 6' -O-acetylsaikosaponin d. Wherein, the saikosaponin a has deeper pharmacological study and multiple nerve inhibition effect; the volatile oil mainly comprises gamma-juniper, beta-ionone, lauric acid and myristic acid; the flavonoids are kaempferol, kaempferol-7-O-alpha-L-rhamnoside, kaempferol-3-O-alpha-L-furan, arabinose-7-O-alpha-L-furanrhamnose, kaempferide, quercetin-3-O-beta-D-glucoside, quercetin, rutin, patchoulide, isorhamnetin-3-O-beta-D-glucoside, narcistin, cactus glycoside, soybean glycoside, puerarin glycoside, 7-hydroxy-2, 5-dimethyl-chromanone and bupleurum chromone A; the polysaccharide component in polysaccharide North Bupleurum consists of L-ara, D-rib, D-xyl, L-hra, D-glc, D-gal and other monosaccharides. The product has pharmacological actions: 1. antipyretic effect: the effective components with antipyretic effect in the north bupleurum root are volatile oil components and saikosaponin components contained in the bupleurum root, and the components have obvious antipyretic effect on fever caused by typhoid, paratyphoid vaccine, escherichia coli liquid, fermented milk, yeast and the like; 2. sedative, analgesic and antitussive effects: the crude saikosaponin has obvious sedative and hypnotic effects, and can prolong hypnotic time of barbital sodium and cyclohexene barbital sodium; 3. anti-inflammatory action: the anti-inflammatory active ingredients of bupleurum are considered as saikosaponin, and the ingredients have inhibiting effects on ankle joint swelling and connective tissue hyperplasia inflammation caused by various inflammatory agents, can reduce capillary permeability, reduce exudation of inflammatory factors, inhibit histamine release and leukocyte migration of inflammatory tissues, and have inhibiting effects on a plurality of links of inflammation occurrence and development; 4. antiviral action: the effective components of saikosaponin and secondary saikosaponin in North Bupleurum have good inhibiting effect on influenza virus, hepatitis virus, vaccinia virus, type I polio virus, herpes virus, etc. The compound can inhibit Na+ -K+ -ATPase of virus, influence energy and water salt metabolism of virus, and thus has antiviral effect.

Cortex Mori:

it is sweet and cold in flavor and enters lung and spleen meridians. The product has effects in purging lung qi, relieving asthma, inducing diuresis, relieving swelling, tonifying deficiency, promoting blood circulation, removing blood stasis, eliminating phlegm, relieving cough, stopping bleeding, promoting salivation, quenching thirst, relieving constipation, expelling parasite, promoting digestion, dispelling pathogenic wind, treating stranguria, and relieving pain. It is used for treating edema, diabetes, tracheitis, pleurisy, pertussis, epistaxis, etc. The product mainly comprises benzofurans, stilbenes, flavonoids, coumarin, other components and the like. The benzofurans compound takes 2-phenyl benzofurans as main parent nucleus, and the parent nucleus is generally connected with common substituent groups or flavonoid compounds; stilbene compounds mainly include:

alboctalol, andelalasin B and macrourin B, D, etc.; the flavonoids mainly comprise Sang Su, sanguisorbate, sang Se alkene, ring Sang Su, ring Sang Se alkene, cyclosanguinarine, sanguisorbate A-L, sanguisorbate C, D, sanguisorbanone A-P, sanguisorbate ketol, sanguisorbate alcohol, cyclosanolol, sanguisorbate leukonin, hydroxydihydrosanguisorbate, sang Pigen hydroperoxide, etc.; the coumarin compound mainly comprises 5, 7-hydroxycoumarin, scopoletin, umbelliferone, scopoletin, etc. The other compounds include 3, 4-dihydroxybenzoic acid ethyl ester, sang Duotang, mulberry furan, betulinic acid, stilbene glycoside compounds, chitosan, mucin, chitin, tannin, volatile oil, etc. Pharmacological action of the product: 1. analgesic and anti-inflammatory effects: the main component of the mulberry bark total flavone (400 mg.kg < -1 >) can obviously inhibit mouse auricle swelling caused by dimethylbenzene and capillary permeability increase caused by acetic acid, which indicates that the mulberry bark total flavone has stronger anti-inflammatory effect; 2. antitussive, expectorant, antiasthmatic, diuretic effects: the mulberry bark glycoside can obviously reduce the times of sulfur dioxide (SO 2), citric acid and strong ammonia water cough, has obvious asthma relieving effect on guinea pig bronchial asthma caused by histamine, can obviously increase the output of tracheal phenol red, can obviously increase the NO content in bronchus, and has the asthma relieving action mechanism related to bronchial relaxation caused by increasing the NO content in bronchus. 3. Hypoglycemic effect: the MTF has particularly remarkable hypoglycemic effect, and has better improving effect on osteoporosis and femoral head lesions caused by diabetes; 4. diastolic effect: the effective parts such as ethyl acetate extract and non-acetone extract of cortex Mori have cardiovascular dilating effect; 5. liver protection effect: cortex Mori Polysaccharide (PCM) can inhibit Vascular Endothelial Growth Factor (VEGF), platelet Derived Growth Factor (PDGF) and messenger RNA (mRNA) expression in liver; 6. anticancer effect: the cortex mori oligosaccharide and the volatile oil can effectively inhibit the growth of tumor cells, and have obvious anticancer effect; 7. immunomodulatory effects: the 30% ethanol fraction of cortex Mori has effects in promoting humoral immunity and cellular immunity. The 50% ethanol component can inhibit the growth of thymus, has an inhibitory effect on nonspecific immunity and cellular immunity, and the fatty oil component can promote humoral immunity; 8. antioxidant effect: the white mulberry root-bark flavone and 3 stilbenes (resveratrol, resveratrol and mulberroside) have stronger biological activities of resisting oxidization and scavenging free radicals.

Thunberg fritillary bulb:

it is bitter in flavor, cold in nature, enters heart and lung meridians. The product has effects of clearing heat, resolving hard mass, eliminating phlegm and relieving cough. It is mainly used for treating wind-heat invading lung, cough due to phlegm-fire, pulmonary abscess, acute mastitis, scrofula, sore and the like. The product mainly contains alkaloid and total saponin, wherein the alkaloid comprises peimine, peiminine, fritillaria, thunberg fritillary, thunberg Bei Tong, fritillaria, choline, fritillaria, phytosterol, dehydro-Bei Ding, sibiricin, ibacterine, zhe Bei Bingsu, jaw Bei Ding, thunberg fritillary, dehydro-thunberg fritillary, and isoperidin A. The saponin comprises fritillary bulb alkali glycoside, western Bei Sugan, zhejiang Ningoside, peimine, ibandroside A, ping Beijian glycoside, etc.; also contains polysaccharide component. Pharmacological action of the product: 1. Cough relieving and phlegm dispelling: five steroid alkaloids of fritillary bulb effective components, namely peimine, sibiricin, western Bei Sugan and Pu Beitong alkali, have antagonism on the tracheal M receptor, and alkaloids in fritillary bulb act on the tracheal M receptor to antagonize the tracheal M receptor and inhibit the contraction of the trachea; 2. pain-relieving and antibacterial: the peimine can play a role in reversing bacterial drug resistance by inhibiting an active efflux pump on a bacterial cell membrane, increasing accumulation of antibiotics in drug-resistant staphylococcus aureus, and the reversing effect is mainly played by regulating the immunity of organisms and improving the sensitivity of the drug-resistant staphylococcus aureus to the antibiotics; anti-ulcer, anti-inflammatory and antidiarrheal: the Bulbus Fritillariae Thunbergii ethanol extract can inhibit water immersion stress and hydrochloric acid gastric ulcer formation, inhibit acetic acid to improve capillary permeability of abdominal cavity, and has antiinflammatory effect; 4. antitumor: the antineoplastic components in fritillaria are mainly alkaloids, wherein the antineoplastic components mainly comprise peimine and peiminine, which have a reverse effect on the drug resistance of tumor cells, can have a synergistic effect with other antineoplastic drugs, and provide an effective way for treating tumors.

Radix angelicae:

it is pungent in flavor and warm in nature, enters lung, spleen and stomach meridians. The product has effects of relieving exterior syndrome, dispelling cold, dispelling pathogenic wind, relieving pain, relieving stuffy nose, eliminating dampness, stopping leukorrhagia, and relieving swelling and pus. Is mainly used for treating headache, glabellar bone pain, odontalgia, nasosinusitis, cold-dampness abdominal pain, intestinal wind and anal fistula, red and white leucorrhea, carbuncle, sore, skin dryness and itching, and scabies. The main components of the product comprise coumarin, volatile oil, glycosides, polysaccharides, amino acids, alkaloids and the like, wherein the coumarin mainly comprises imperatorin, isoimperatorin, oxidized imperatorin, hydrated oxidized imperatorin, xanthotoxin, white angelica brain and isopsoralen, and the volatile oil mainly comprises pentadecanol, dodecanol and oleyl alcohol, and 3 volatile components; the glycosides mainly comprise fructus Aurantii Immaturus glycoside, isofraxidin-7-O-beta-D-glucopyranoside, benzyl-O-beta-D-glucopyranoside, scopolamine, (2 'R) -5' -hydroxy-fructus Aurantii Immaturus aglycone-5 '-O-beta-D-glucopyranoside, (2' S,3 'R) -3' -hydroxy-fructus Aurantii Immaturus glycoside, skimmia japonica glycoside, etc.; the polysaccharides mainly comprise 6 monosaccharides including rhamnose, arabinose, xylose, mannose, glucose and galactose; amino acids: the arginine content in the non-essential amino acid is the highest, the leucine content in the essential amino acid is the highest, and the alkaloids mainly comprise desmodium styracifolium, angelica dahurica alkali A-F and the like. Pharmacological action of the product: 1. anti-inflammatory action: radix Angelicae Dahuricae can treat acne by acting on interleukin, metalloproteinase tissue inhibitor, serum insulin-like growth factor, androgen receptor target, interfering phosphatidylinositol-3-kinase/serine threonine protein kinase, nuclear factor kappa B, mitogen activated protein kinase, fibroblast growth factor receptor 2 signal pathway to mediate organism inflammatory reaction, immune reaction, sebum secretion, etc.; 2. analgesic effect: the coumarin components of radix Angelicae Dahuricae such as imperatorin and isoimperatorin can be combined with 5-hydroxytryptamine, acetylcholine, thromboxane-prostaglandin, etc., and can assist rhizoma corydalis in relieving pain by mediating signal paths related to spasm and inflammation; 3. whitening: radix Angelicae Dahuricae has whitening effect by inhibiting tyrosinase activity; 4. photosensitivity: some coumarin components such as bergamot lactone in radix Angelicae Dahuricae have the effect of activating tyrosine kinase, and the use of radix Angelicae Dahuricae photosensitivity for treating psoriasis has been reported in the early years. 5. Antibacterial: the radix Angelicae Dahuricae extract has inhibiting effect on Staphylococcus aureus, staphylococcus epidermidis, proteus, salmonella typhi, bacillus subtilis, pseudomonas aeruginosa, escherichia coli, klebsiella pneumoniae, porphyromonas, anaerobic Streptococcus mutans, and Gardnerella vaginalis; 6. antiallergic: more than 10 coumarin components such as oxypeucedanin, bergamot lactone, sarcodictyins and the like can inhibit the release of histamine, and reduce the secretion of inflammatory cytokines IL-1 beta, IL-4 and TNF-alpha by inhibiting the activation of NF- κB channels; 7. vasodilation, the vasodilation activity of which is mediated by endothelial dependent pathways, including blocking extracellular calcium influx via receptor-mediated ca2+ channels and voltage-dependent calcium channels; 8. antitumor: the radix Angelicae Dahuricae ethanol extract can inhibit the growth of B16F10 melanoma cells by promoting the down regulation of Matrix Metalloproteinase (MMP) activity and its expression, and inducing mitochondrial mediated endogenous apoptosis pathway.

Medicated leaven:

it is sweet and pungent in flavor, warm in nature, and enters spleen and stomach meridians. The product has effects of invigorating spleen, regulating stomach function, promoting digestion, and regulating middle warmer, and has vitamin B group-like effects such as stimulating appetite, and maintaining normal digestion. Is mainly used for treating dyspepsia and heart pain, summer-heat and sudden diarrhea, food injury, chest and diaphragm stuffiness and oppression, infantile diarrhea, abdominal pain or diarrhea, dysphagia and puerperal galactorrhea of large people. The main ingredients of the product comprise volatile oil, vitamin B group, ergosterol, glycosides, amylase, protease, etc. As the medicated leaven is a medicine obtained by co-fermenting a plurality of raw materials, the chemical components are extremely complex and the content is low, and the trace active substances in the medicated leaven are difficult to be obtained efficiently by the existing chemical separation means. Pharmacological action of the product: can increase secretion of gastrin and cholinesterase, reduce NO content in serum, repair intestinal ulcer, enhance contraction of intestinal smooth muscle, increase beneficial flora, and inhibit growth of enterobacteria. The medicated leaven also contains abundant digestive enzymes, and amylase, protease and the like are produced by decomposing a fermentation matrix by special microorganisms or microorganism groups in the fermentation process, so that the effects of invigorating stomach and promoting digestion are achieved.

Sweet wormwood herb:

it is bitter and pungent in flavor, cold in nature, enters liver and gallbladder meridians. The product has effects of clearing away deficiency heat, cooling blood, removing heat, relieving summer-heat, and stopping malaria, and is mainly used for treating pathogenic warm injury yin, night fever, yin deficiency fever, bone steaming fatigue heat, summer-heat, malaria cold heat, and damp-heat jaundice. The main components of the product are sesquiterpene, diterpene, flavone, phenylpropionic acid, coumarin, volatile oil and the like. Sesquiterpenes: the main chemical components in sweet wormwood herb, especially artemisinin with antimalarial effect, are the best known. Sesquiterpenes are sequentially separated from herba Artemisiae Annuae, such as arteannuin A, arteannuin B, arteannuin C, dihydrodeoxyarteannuin B, deoxyarteannuin B, and arteannuin. Pharmacological action of the product: 1. antimalarial effect: the action mechanisms of artemisinin compounds for antimalarial activity include: (1) The peroxy bridge bond is an important part artemisinin which plays an antimalarial activity, and generates peroxy bridge bond rupture under the catalysis of hemoglobin Fe & lt2+ & gt to generate oxygen and carbon free radicals which can block nutrition absorption of plasmodium along with amino acid residues near an organic alkylation binding site, and simultaneously, autophagosomes are rapidly formed to lack nutrition to cause amino acid starved protozoon excretions so as to play a role in eliminating the plasmodium; (2) Under the catalysis of a certain amount of Fe & lt2+ & gt, artemisinin generates free radicals with carbon as a center, activated artemisinin acts on plasmodium calcium ATP protein 6 (PfATP 6) in a targeted manner by virtue of a hydrophobic framework of the artemisinin, so that the concentration of calcium ions in plasmodium cytoplasm is increased, and the insecticidal antimalarial effect is exerted. 2. Antitumor effect: the sesquiterpene lactone and flavonoid components in the sweet wormwood herb have good anti-tumor activity, and the sweet wormwood herb derivative can inhibit proliferation of cervical cancer HeLa cells in vitro and promote apoptosis of the cervical cancer HeLa cells. 3. Antibacterial and insecticidal effects: the volatile oil in the sweet wormwood herb has remarkable inhibition effect on enterococcus, candida albicans and microzyme, and the scheme of combining the sweet wormwood herb derivative preparation (dihydrosweet wormwood herb piperaquine phosphate tablet and sweet wormwood herb tiger lipid tablet) and the compound sulfamethoxazole with azithromycin is an effective medicament for treating toxoplasmosis. 4. Antipyretic and antiinflammatory effects: the water extract of sweet wormwood, ethyl acetate and n-butyl alcohol have obvious effects of relieving fever and resisting high temperature. Artemisinin exerts anti-inflammatory effects by modulating nuclear transcription factor- κb (NF- κb) and mitogen-activated protein kinase (MAPK) signaling pathways. 5. Immunomodulatory effects: the method directly or indirectly reduces the serum R97-116 antibody level, inhibits the secretion of gamma interferon (IFN-gamma) and IL-17 pro-inflammatory factors by lymph node mononuclear cells, and has better curative effect on systemic lupus erythematosus by artemisinin and derivatives thereof.

Folium Isatidis

It is bitter in property and cold in flavor, entering liver, heart and stomach meridians. The product has effects of clearing heat, removing toxic substances, cooling blood, and stopping bleeding, and can be used for treating excessive heat, polydipsia, influenza, acute infectious hepatitis, bacillary dysentery, acute gastroenteritis, acute pneumonia, erysipelas, hematemesis, epistaxis, jaundice, dysentery, pharyngitis, aphtha, carbuncle, and pyogenic infections. The main components of the product are indole compounds, quinazolinone compounds, glucosinolate compounds, organic acid compounds and the like. The indole compounds all contain indigo blue and indirubin, isatis tinctoria leaves contain Isatis tinctoria glycoside B, and Isatis tinctoria leaves contain isoindigo blue; the quinazolinone compounds include 4 (3H) quinazolinone, 2,4 (1H, 2H) quinazolinone and tryptanthrin; the glucosinolates include glucosinolates, neoglucosinolates, 1-sulfoglucosinolates; the organic acid compound comprises 1-thiocyanate-2-hydroxy-3-butene, anthranilic acid, benzoic acid, syringic acid, salicylic acid, palmitic acid and the like. The pharmacological action of the product is as follows: 1. antibacterial action: the dyers woad leaf extracts (water extract, ethanol extract and n-butanol extract) have different degrees of antibacterial effect on experimental bacteria, wherein the antibacterial effect on staphylococcus aureus is most obvious. 2. Antiviral action: the 4 (3H) quinazolinone in folium Isatidis has effects in inhibiting influenza virus and Coxsackie virus, inhibiting infection of influenza A virus, japanese encephalitis virus, mumps virus and influenza virus, and inhibiting proliferation. 3. Antiendotoxin activity: the n-butanol extraction part of the dyers woad leaf can directly neutralize and degrade endotoxin, the pyrogenicity and lethality of the endotoxin are obviously reduced, the activity strength of the dyers woad leaf against the endotoxin is closely related to chemical components such as organic acids, amino acids and the like contained in the dyers woad leaf, and the components directly inactivate bacterial endotoxin, inhibit the toxic biological effect of the bacterial endotoxin or enhance the immunity of an organism to resist toxin invasion, thereby playing a durable and beneficial role of resisting the endotoxin. 4. Action on the immune system: the dyers woad leaf decoction can up-regulate immune function by promoting secretion of lymphocyte IL-2, and has no obvious influence on inflammatory effect and immunopathogenic injury caused by secretion of TNF by macrophages. 5. Anticancer effect: indirubin participates in regulating the metabolism of lung cancer cells by inducing the activities of cytochrome P450A 1 and 1B1 mRNA enzymes in MCF-7 lung cancer cells, achieves the anti-tumor effect, has a strong inhibition effect on animal transplantable tumors, and has a good curative effect on chronic granulocytic leukemia.

Compared with the prior art, the invention has the following beneficial effects:

the traditional Chinese medicine formula particle composition is used for treating acute upper respiratory tract infection, can obviously accelerate the relief of symptoms such as fever and the like, and promotes the recovery of diseases; the traditional Chinese medicine has the effects of clearing lung, bringing down fever and the like, and has reliable curative effect; the raw materials are easy to obtain, the price is low, the preparation is convenient, and the application range is wide.

The traditional Chinese medicine composition has reasonable formula, proper and scientific compatibility of medicines, abundant medicinal material sources, moderate price, convenient material acquisition, convenient preparation and mastery, and can be used for distinguishing symptoms and signs. Is suitable for treating and preventing upper respiratory tract infection. Clinical researches show that the medicine has obvious treatment effect on acute upper respiratory tract infection.

The invention is an add-drop prescription based on the Xu Zhiying effect checking prescription of the medical famous chef in Zhejiang province, and has definite curative effect through clinical application. In addition, the medicine for treating acute upper respiratory tract infection has obvious clinical treatment effect after clinical research and observation of hundreds of patients. The medicine of the present invention is used in treating acute upper respiratory tract infection, and has the advantages of fever elimination, stable symptom control, and 0-4 days in advance from fever to normal body temperature. Stable disease state, reliable lung-heat clearing and antipyretic effects.

The traditional Chinese medicine formula particle composition can be used for combining four diagnoses of traditional Chinese medicine for patient symptoms before explicit diagnosis is performed in modern medicine, has definite curative effect and has good compliance.

Drawings

FIG. 1 is a box diagram of each group of defervescence time;

figure 2 is a bar graph of the efficacy of each group.

Detailed Description

15g of stir-fried baical skullcap root, 9g of perilla leaf, 30g of dyers woad leaf, 9g of mint, 12g of platycodon grandiflorum, 9g of radix peucedani, 9g of north bupleurum, 12g of white mulberry root-bark, 12g of thunberg fritillary bulb, 15g of dahurian angelica root, 15g of medicated leaven (namely, burnt medicated leaven), 30g of sweet wormwood, 30g of wild buckwheat rhizome and 9g of blackberry lily prescription granule are selected, evenly mixed and divided into 2 bags, and each bag is divided into morning and evening. When in use, a bag is torn open, poured into a cup, added with boiled water for brewing, and fully stirred until dissolved.

The invention relates to partial clinical data for treating acute upper respiratory tract infection

The effect of treating acute upper respiratory tract infection by using the traditional Chinese medicine composition of the invention is illustrated, and the traditional Chinese medicine formula particle composition is applied to treating patients suffering from acute upper respiratory tract infection, wherein the specific content is as follows:

a treatment object: 200 patients with fever from 30 days 1 month in 2020 to 8 months 30 days in 2020 are divided into 50 patients in traditional Chinese medicine treatment groups (traditional Chinese medicine formula particle composition of the invention is used for adding western medicines for conventional treatment) and 150 patients in conventional treatment groups (western medicines for conventional treatment). The treatment is carried out according to the treatment scheme, and records are made according to the follow-up result after the treatment. Patients with the falling-off failure and failure to complete the given treatment scheme according to the doctor's advice are removed, and meanwhile, misdiagnosis cases (1 perianal abscess and 2 appendicitis) and adverse drug reaction cases (1 left ofloxacin) are removed. 167 cases of patient data were recorded, of which 97 cases for men and 70 cases for women; 24 cases of 10-19 years old, 46 cases of 20-29 years old, 37 cases of 30-39 years old, 24 cases of 40-49 years old, 16 cases of 50-59 years old, 10 cases of 60-69 years old, 8 cases of 70-79 years old and 2 cases above 80 years old. The most common symptoms counted were fever 155/167 (92.8%), cough 51/167 (30.5%), sore throat 34/167 (20.4%), hypodynamia 29/167 (17.4%), headache 29/167 (17.4%), aversion to cold 29/167 (17.4%), nasal obstruction 28/167 (16.8%), runny nose 25/167 (15.0%), dizziness 16/167 (9.6%), expectoration 13/167 (7.8%).

Of these, 38 cases in the traditional Chinese medicine treatment group and 129 cases in the conventional treatment group. There were no statistical differences in age, sex, and condition (P > 0.05) between the two groups.

The treatment method comprises the following steps: the conventional treatment group can give symptomatic treatment such as oxygen inhalation, antivirus, anti-infection, phlegm eliminating, cough relieving and the like according to the specific illness state of patients and basically support treatment. The traditional Chinese medicine treatment group is added with the traditional Chinese medicine formula granule composition for oral administration on the basis of the treatment scheme of the conventional treatment group, and is treated for 3-6 days.

Determination of efficacy (formulated according to the guidelines for clinical research on New Chinese medicine (trial) 2002, zhengyu main code):

and (3) healing: the body temperature returns to normal within 3 days after treatment, and the symptoms of upper respiratory tract infection completely disappear.

The effect is shown: the body temperature is normal within 3 days of treatment, and the symptoms of upper respiratory tract infection are mostly disappeared.

The method is effective: the body temperature is reduced within 3 days of treatment compared with the prior art, and the main symptom part of the upper respiratory tract infection disappears.

Invalidation: the body temperature is not reduced or increased within 3 days of treatment, and the main symptoms of the upper respiratory tract infection are not improved.

And (3) statistical treatment: the distribution of the data of the metering data adopts t test or nonparametric statistics. X for counting data ² And (5) checking, wherein rank sum checking is adopted for the grade data. At p<0.05 indicates that the difference is statistically significant.

Treatment results:

(1) Antipyretic effect: the defervescence time of the traditional Chinese medicine treatment group is 0.5-3 days, and the median is as follows: 1 (0.5 to 1) day; the conventional treatment group had an defervescence time of 0.5-7 days, median: 1 (0.5-2) day. The data are found to be non-normal distribution by inspection, and the antipyretic effect of the traditional Chinese medicine treatment group is obvious by comparison of Mannheimia detection, and the antipyretic effect of the traditional Chinese medicine treatment group is obviously different from that of the traditional treatment group (p is less than 0.05), and the detailed table 1 is shown. The respective sets of defervescence time-box diagrams are shown in fig. 1.

Table 1 comparison of antipyretic time in granule group with conventional treatment group

	Time of defervescence	Z	p
				Traditional Chinese medicine	1(0.5～1)	-2.073	0.038
Conventional method	1(0.5～2)

(2) The main symptom treatment effect is as follows:

167 patients recorded were treated, cured 94 (56.29%), developed 24 (14.37%), effective 27 (16.17%), and ineffective 22 (13.17%). After comparison, the curative effect of the traditional Chinese medicine treatment group is superior to that of the conventional treatment group, and the traditional Chinese medicine treatment group has obvious difference (p < 0.01), and is shown in Table 2.

Table 2 comparison of efficacy of granule group with conventional treatment group

Typical cases:

1. the patient Zhou Mou, men, 18 years old, is diagnosed by 'pharyngalgia fever 1 day' on 3 months and 3 days in 2020, and the pharyngalgia fever appears under no obvious causes before 1 day, and is accompanied by poor appetite, nasal obstruction, headache, cough, expectoration, chest distress, and dyspnea, and physical examination: 38.9 ℃, P96/min, R22/min, BP:120/70mmhg, clear mind, no facial macula, 2020.3.3 chest CT plain scan did not see obvious abnormalities. 2020/3/3 blood test routine shows: white blood cells 12.54 x 10≡9/L; 6.00mg/L of C-reactive protein; neutrophil% 75.8%; neutrophil count 9.5110≡9/L; lymphocyte count 1.5810≡9/L; lymphocyte% 12.6%; 2020/3/3 influenza A virus antigen (colloidal gold method) negative; influenza b virus antigen (colloidal gold method) negative; primary diagnosis: acute pharyngolaryngitis and hyponatremia. The Chinese medicinal composition granule is taken after instant transfusion, anti-infection and symptomatic treatment, and comprises the following components: 15g of fried baikal skullcap root, 9g of perilla leaf, 30g of dyers woad leaf, 9g of peppermint, 12g of platycodon root, 9g of radix peucedani, 9g of north bupleurum root, 12g of white mulberry root-bark, 12g of fritillaria thunbergii, 15g of dahurian angelica root, 15g of medicated leaven, 30g of sweet wormwood herb, 30g of wild buckwheat rhizome and 9g of blackberry lily. 3 doses are taken orally twice a day, after taking for one day, the self-induced symptoms are obviously reduced, the body temperature is reduced to be normal, and after taking for three days, other symptoms such as pharyngalgia disappear, and the disease is cured.

2. The patient Wang Mou, the woman and the 19 years old are diagnosed by 'febrile day 1' in month 4 and 18 of 2020, and the patient has febrile, nasal discharge and nasal obstruction with cough, headache, no muscle ache, no improvement of self-taking medicine and current diagnosis before 1 day. Last menstruation 2020.02.05, check body: 39.6 ℃, P98/min, R23/min, BP:126/75mmhg,2020/4/18 white blood cells 10.70 x 10≡9/L; 6.4% of monocytes; 21mg/L of C-reactive protein; neutrophil% 82.5%; basophil% 0.2%;2020/4/18 influenza A virus antigen (colloidal gold method) negative; influenza b virus antigen (colloidal gold method) negative; chest CT was not seen with obvious abnormalities. Primary diagnosis: the invention relates to a Chinese medicinal composition granule for treating acute upper respiratory tract infection, which is prepared by immediately carrying out infusion, anti-infection and symptomatic treatment, and comprises the following components: 15g of fried baikal skullcap root, 9g of perilla leaf, 30g of dyers woad leaf, 9g of peppermint, 12g of platycodon root, 9g of radix peucedani, 9g of north bupleurum root, 12g of white mulberry root-bark, 12g of fritillaria thunbergii, 15g of dahurian angelica root, 15g of medicated leaven, 30g of sweet wormwood herb, 30g of wild buckwheat rhizome and 9g of blackberry lily. 3. The preparation is taken orally twice a day, after one day, the self-induced symptoms are relieved, the body temperature is reduced to be normal in the second day, and other symptoms are relieved after two or three days.

3. Patients Li Mou, 23 years old, were diagnosed by "fever 1 day" on day 14, 4, 2020, and had fever discomfort with nasal obstruction, nasal discharge, and pharyngalgia before 1 day. Checking: 38.6 ℃, P86/min, R21/min, BP:118/78mmhg,2020/4/14 white blood cells 10.16 x 10≡9/L; hemoglobin 168g/L; 7mg/L of C-reactive protein; neutrophil% 87.6%; 3.5% of monocytes; influenza a virus antigen (colloidal gold method) negative; influenza b virus antigen (colloidal gold method) negative; there was no obvious abnormality in chest CT plain scan. Primary diagnosis: the invention relates to a Chinese medicinal composition granule for treating acute upper respiratory tract infection, which is prepared by immediately carrying out infusion, anti-infection and symptomatic treatment, and comprises the following components: 15g of fried baikal skullcap root, 9g of perilla leaf, 30g of dyers woad leaf, 9g of peppermint, 12g of platycodon root, 9g of radix peucedani, 9g of north bupleurum root, 12g of white mulberry root-bark, 12g of fritillaria thunbergii, 15g of dahurian angelica root, 15g of medicated leaven, 30g of sweet wormwood herb, 30g of wild buckwheat rhizome and 9g of blackberry lily. 3 doses are taken orally twice daily, after one day, the symptoms are relieved before, and after the third day, the body temperature symptoms and other symptoms are relieved.

4. The patient is 1 day old and is diagnosed by "pharyngalgia fever 1 day" on 4 months and 7 days in 2020, and the patient starts to feel pharyngalgia discomfort in 1 morning with subjective fever discomfort, cough, no phlegm, no nasal obstruction and nasal discharge, no nausea and vomiting. Body temperature measurement: chest CT at 39.4 ℃): the two lung textures are slightly increased; the upper right lung and lower left lung are slightly scattered in infection; please review the follow-up visit in combination with the clinic and if necessary. Primary diagnosis: the invention relates to a Chinese medicinal composition granule for treating acute upper respiratory tract infection and pulmonary infection, which is prepared by immediately carrying out transfusion, anti-infection and symptomatic treatment, and comprises the following components: 15g of fried baikal skullcap root, 9g of perilla leaf, 30g of dyers woad leaf, 9g of peppermint, 12g of platycodon root, 9g of radix peucedani, 9g of north bupleurum root, 12g of white mulberry root-bark, 12g of fritillaria thunbergii, 15g of dahurian angelica root, 15g of medicated leaven, 30g of sweet wormwood herb, 30g of wild buckwheat rhizome and 9g of blackberry lily. 3 doses are taken orally twice a day, after one day, the symptoms are relieved before, and after the third day, the body temperature symptoms and other symptoms are relieved.

5. Patients Wang Mou, 35 years old, were diagnosed by "cough, fever 1 day" in 3 months and 15 days in 2020, and had no obvious causes before 1 day, with cough, fever, debilitation, general muscular soreness, no obvious expectoration, no nasal obstruction, and no pharyngalgia. Measuring the body temperature at 38.0 ℃,2020/3/15 blood normal white blood cells at 14.2810A 9/L; 17.00mg/L of C-reactive protein; neutrophil% 85.1%; neutrophil count 12.1610≡9/L; lymphocyte% 5.2%; lymphocyte count 0.7410≡9/L;2020/3/15 influenza A virus antigen (colloidal gold method) negative; influenza b virus antigen (colloidal gold method) negative; 2020/3/15 emergency sodium (acute) 131.1mmol/L; primary diagnosis: the invention relates to a Chinese medicinal composition granule for treating acute upper respiratory tract infection, which is prepared by immediately carrying out infusion, anti-infection and symptomatic treatment, and comprises the following components: 15g of fried baikal skullcap root, 9g of perilla leaf, 30g of dyers woad leaf, 9g of peppermint, 12g of platycodon root, 9g of radix peucedani, 9g of north bupleurum root, 12g of white mulberry root-bark, 12g of fritillaria thunbergii, 15g of dahurian angelica root, 15g of medicated leaven, 30g of sweet wormwood herb, 30g of wild buckwheat rhizome and 9g of blackberry lily. 3 doses are taken orally twice daily, after taking one dose, the patient feels that the symptoms are obviously improved, the body temperature is normal in the day, and other symptoms are relieved.

The invention relates to a traditional Chinese medicine for clearing lung and reducing fever, which comprises the following components in parts by weight: 15-30 parts of wild buckwheat rhizome, 9-15 parts of stir-fried baical skullcap root, 4-9 parts of perilla leaf, 4-9 parts of mint, 4-9 parts of north bupleurum root, 15-30 parts of sweet wormwood herb and 15-30 parts of dyers woad leaf. The traditional Chinese medicine composition is used for treating acute upper respiratory tract infection, can obviously accelerate the relief of fever symptoms, and effectively treats various common symptoms caused by upper respiratory tract infection. The medicine of the invention has reliable curative effect of clearing lung and bringing down fever, and has the advantages of easily available materials, low price, convenient acquisition and wide application range. The medicine for treating acute upper respiratory tract infection has obvious clinical treatment effect after years of research and clinical observation of hundreds of patients. The medicine of the present invention can treat acute upper respiratory tract infection, and has fast fever subsidence, normal fever and body temperature, and different time period from 0-4 days. The other upper respiratory tract infection symptoms subside steadily, and the curative effect is obvious compared with other treatment groups.

Claims (2)

1. A traditional Chinese medicine for clearing lung and reducing fever is characterized in that: the traditional Chinese medicine composition comprises, by weight, 15-30 parts of wild buckwheat rhizome, 9-15 parts of stir-fried baical skullcap root, 4-9 parts of perilla leaf, 4-9 parts of peppermint, 4-9 parts of radix peucedani, 4-9 parts of north bupleurum, 15-30 parts of sweet wormwood herb, 15-30 parts of dyers woad leaf, 4-9 parts of blackberry lily, 4-12 parts of platycodon root, 4-12 parts of white mulberry root-bark, 4-12 parts of thunberg fritillary bulb, 4-15 parts of dahurian angelica root and 9-15 parts of medicated leaven.

2. The use of the lung-heat clearing and defervescing traditional Chinese medicine according to claim 1 in the preparation of a medicament for treating acute upper respiratory tract infection.