CN109432165A - A kind of anaesthetic and preparation method thereof for treating asthma - Google Patents

A kind of anaesthetic and preparation method thereof for treating asthma Download PDF

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Publication number
CN109432165A
CN109432165A CN201811575416.0A CN201811575416A CN109432165A CN 109432165 A CN109432165 A CN 109432165A CN 201811575416 A CN201811575416 A CN 201811575416A CN 109432165 A CN109432165 A CN 109432165A
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parts
anaesthetic
preparation
asthma
volatile oil
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不公告发明人
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AFFILIATED HOSPITAL OF INNER MONGOLIA UNIVERSITY FOR NATIONALITIES
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AFFILIATED HOSPITAL OF INNER MONGOLIA UNIVERSITY FOR NATIONALITIES
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Abstract

The present invention relates to a kind of drug and preparation method, i.e., a kind of anaesthetic and preparation method thereof for treating asthma.It is characterized by: the anaesthetic includes the bulk pharmaceutical chemicals of following parts by weight: 10-15 parts of oxtongue, 0.5-0.7 part of Banlangen, 0.06-0.08 part of alantolactone, 0.5-0.7 part of ursolic acid, 1-2 parts of crocin, 0.05-0.07 part of Kaempferol.Preparation method, it is characterised in that: the bulk pharmaceutical chemicals be crushed into 80 meshes, mix, powder or water-bindered pill agent or tablet is made.Beneficial effect is: providing a kind of pair of asthma with significant curative effect, and the mechanism of action is clear, active component is clear, taking dose is small, it is quickly effective, it has no toxic side effect, convenient for the anaesthetic for the treatment asthma taken, and the preparation method that the crude drug for breaking traditional mongolian medicine crushes, using modern science and technology, have developed a kind of environmentally protective, preparation method is simple, the preparation method to match with above-mentioned anaesthetic has played the maximum effect of above-mentioned anaesthetic.

Description

A kind of anaesthetic and preparation method thereof for treating asthma
Technical field
The present invention relates to a kind of drug and preparation method, i.e., a kind of anaesthetic and preparation method thereof for treating asthma.
Background technique
Asthma is the abbreviation of bronchial asthma.Bronchial asthma is that (such as eosinophil, hypertrophy are thin by various kinds of cell Born of the same parents, T lymphocyte, neutrophil leucocyte, human airway epithelial cells etc.) and cellular component participation chronic airway inflammation illness.It is this Chronic inflammation leads to the generation of airway hyperreactivity, generally occurs within reversible airflow limitation changeable extensively, and cause to send out repeatedly Make wheeze, be out of breath, the symptoms such as uncomfortable in chest or cough, often in night and (or) morning breaking-out, most of patients voluntarily can alleviate or pass through Treatment is alleviated.
Mongolian medicine thinks that for the disease mainly due to three unbalance, Xi La and Ba Dagan Xiang Bohou acts on airway walls, then Department's life is conspicuous according to dysfunction, leads to the disease.Be mainly shown as repeatability wheeze, be uncomfortable in chest, shortness of breath, cough, expectoration, expiratory dyspnea, Whistling sound in the throat etc..The common anaesthetic of Mongolian medicine has the equal drugs of Ah loud, high-pitched sound day -8, Ba Te -7, E and wood -8, equal to asthma With good therapeutic effect, as classical Mongolian medicine's proved recipe, although the treatment works well, due to lacking modern technologies hand Section, the mechanism of action of drug is relatively fuzzyyer, and effective component is mostly uncertain, and is all made of traditional preparation method, is mixed into effective component A large amount of invalid components, so that taking dose is big, slowly effective, toxic side effect is strong, and the equal flavour of a drug of anaesthetic are big, limits opening for anaesthetic Hair utilizes.
Summary of the invention
The object of the present invention is to provide a kind of pair of asthma to have significant curative effect, and the mechanism of action is clear, and active component is clear, Taking dose is small, quickly effective, has no toxic side effect, convenient for the preparation method of the anaesthetic for the treatment of asthma and this drug taken.
Above-mentioned purpose is realized by the following technical solutions: a kind of anaesthetic for treating asthma, it is characterised in that: the anaesthetic Bulk pharmaceutical chemicals including following parts by weight: 10-15 parts of oxtongue, 0.5-0.7 part of Banlangen, alantolactone 0.06-0.08 Part, 0.5-0.7 part of ursolic acid, 1-2 parts of crocin, 0.05-0.07 part of Kaempferol.
The raw material medicaments in part by weight is added: 5-7 parts of fructus choerospondiatis, 5-7 parts of falsespiraea tree bark, and 9-11 parts of Inula britannica chinensis, myrobalan 5-7 parts.
The raw material medicaments in part by weight is added: 5-7 parts of Radix picrorrhizae, 5-7 parts of common bombax flower, and 9-11 parts of nutmeg, Strychnos nux-vomica 9-11 parts, 6-8 parts of Fructus meliae toosendan of sub (system).
The raw material medicaments in part by weight is added: 5-7 parts of agalloch eaglewood, 12-13 parts of dalbergia wood, and 12-13 parts of mountain agalloch eaglewood, costus root 9-11 parts, 9-11 parts of cloves.
Described 0.5-0.7 part of Banlangen is substituted by 5-7 parts of kuh-seng, and 0.06-0.08 part of alantolactone by building Fragrant 5-6 parts of substitutions, 0.5-0.7 part of ursolic acid, 1-2 parts of crocin substituted by 38-42 parts of cape jasmines, Kaempferol 0.05- 0.07 part is substituted by 5-7 parts of kaempferia galamgas.
A kind of preparation method of anaesthetic that treating asthma, it is characterised in that: the bulk pharmaceutical chemicals be crushed into 80 meshes, mixed It is even, powder or water-bindered pill agent or tablet is made.
A kind of preparation method of anaesthetic that treating asthma, it is characterised in that: by the agalloch eaglewood in bulk pharmaceutical chemicals, dalbergia wood, mountain agalloch eaglewood, Costus root, cloves are ground into coarse powder, add distilled water, impregnate 30min, are placed in volatile oil extractor, add water, past medicine Material liquid level 3-4cm, heating water bath collect the volatile oil that above-mentioned raw materials medicine extracts, spare, then remaining drug crushed 80 Mesh adds 75% alcohol reflux to extract 1-2 hours, and filtrate is collected in filtering, and concentration obtains concentrate, uniform with above-mentioned volatile oil Mixing, adds auxiliary material, pill is made.
A kind of preparation method of anaesthetic that treating asthma, it is characterised in that: by the agalloch eaglewood in bulk pharmaceutical chemicals, dalbergia wood, mountain agalloch eaglewood, Costus root, cloves are ground into coarse powder, add distilled water, impregnate 30min, are placed in volatile oil extractor, add water, past medicine Material liquid level 3-4cm, heating water bath collect the volatile oil that above-mentioned raw materials medicine extracts, spare, then remaining drug crushed 80 Mesh filters first with being washed under the conditions of 70 DEG C of petroleum ether to it, discards filtrate, filter residue adds 75% alcohol reflux to extract 1-2 hours, filtrate was collected in filtering, and concentration obtains concentrate, uniformly mixes with above-mentioned volatile oil, add auxiliary material, pill is made.
The beneficial effects of the present invention are: providing a kind of pair of asthma with significant curative effect, and the mechanism of action is clear, effective portion Position is clear, and taking dose is small, quickly effective, has no toxic side effect, convenient for the anaesthetic for the treatment asthma taken, and breaks traditional mongolian medicine The preparation method that crushes of crude drug have developed a kind of environmentally protective using modern science and technology, preparation method is simple, with above-mentioned anaesthetic The preparation method to match has played the maximum effect of above-mentioned anaesthetic.
Specific embodiment
The first embodiment:
A kind of anaesthetic for treating asthma is developed, the bulk pharmaceutical chemicals including following parts by weight: 10-15 parts of oxtongue, Banlangen 0.5-0.7 part, 0.06-0.08 part of alantolactone, 0.5-0.7 part of ursolic acid, 1-2 parts of crocin, Kaempferol 0.05-0.07 part.It is preferred that 12.5 parts of oxtongue, 0.6 part of Banlangen, 0.07 part of alantolactone, 0.6 part of ursolic acid, hiding 1.5 parts of carthamin, 0.06 part of Kaempferol.
Preparation method: crushed 80 meshes for the bulk pharmaceutical chemicals, mixes, powder or water-bindered pill agent or tablet is made.It is preferred that water Ball.
Instructions of taking: oral, the amount of adult 0.5-1.5g(amount containing main ingredient — that is, the drug in addition to auxiliary material)/time, it takes daily 2-3 times.
Bulk pharmaceutical chemicals brief introduction:
Oxtongue, anaesthetic name, Xi Tu is such as ancient (Four-Volume Medical Code), alias: rifle knife dish, uncommon day one be bright to account for, Cha Xiba mono- its its Lattice, scientific name: PicrisjaponicaThunb. (composite family).Chemical component: aerial part contains flavone compound, alkaloid.Leaf, Colored and Pi Zhonghan oleanolic acid, taraxerol (Taraxerol), ursolic acid, betulic acid, Lupeol (Lupeol), β- Sitosterol, β-amyrin.Also contain terpene substances.Nature,taste and action: it is Chinese medicine bitter, pungent, it is cool in nature.Purging fire for removing toxin, stasis-dispelling and pain-killing, benefit Urine.Anaesthetic bitter is cool in nature, rough.Heat-clearing is detoxified, and detumescence is killed " viscous ", is relieved pain.Chinese medicine controls ulcerative carbuncle pyogenic infections, and traumatic injury is let out It rushes down, difficult urination.Anaesthetic controls pestilence, influenza, battle array shouting pain, " hair disease ", acute mastitis.
Banlangen is extracted from radix sophorae, Sophora alopecuroide, root of subprostrate sophora etc., and micro- smelly, taste is extremely bitter, have draw it is moist.In ethyl alcohol, chlorine It easily dissolves in imitative, acetone, is largely dissolved in ether.Pharmacological action are as follows: increasing leukocyte number reinforces immunity of organisms, and Play the infection such as anti-shigella dysenteriae, dermatophyte, Amoeba, trichomonad.Still there is diuresis, relieving asthma, hypnosis, the mistake of the anti-rhythm of the heart The effects of normal.It is for oral administration to treat acute bacillary dysentery, tonsillitis, mazoitis, pelvic inflammatory disease, lymphnoditis, upper sense, bronchitis, asthma Breath, arrhythmia cordis, leucocyte are low etc., can also be effective to psoriasis and insomnia.Kuh-seng external application can control trichomoniasis, women's vulva scabies Itch, cervicitis, eczema etc..(the medical grade matrine that Xi'an Sen Zhuo Biotechnology Co., Ltd improves)
Alantolactone, English name: alantolactone, molecular formula: C15H20O2, plant origin: compositae plant elecampane Dissolubility: the dry root of Inula helenium L is soluble in ethyl alcohol, chloroform, benzene, is practically insoluble in water.According to relevant information, The anthelmintic action of alantolactone is good compared with santonin effect and toxicity is lower.Antibacterial action exists through in vitro test, alantolactone When 0.1 μ g/ml concentration, the growth of tubercle bacillus can be inhibited.The cavy of Bacillus tuberculosis is infected, alantolactone is taken orally, Energy delayed onset, but cannot completely inhibit.Trichophyton mentagrophytes, size can be completely inhibited when concentration is 30,40,70 and 80ug/ml The growth of pityrosporion ovale, Paecilomycesliacinus and Rhizotonia.The spore of complete inhibition Fusar-iumsolani is sprouted Hair can block glucose-V-14C to seep synthetic macromolecule completely in 400ug/ml.
Ursolic acid, original name Ursolic Acid, also known as malol, ursolic acid, has special smell, is to be present in natural plant One of object pentacyclic triterpenoid.Still it is soluble in methanol, acetone, pyridine, not soluble in water and petroleum ether.Liver protection, anti-liver Inflammation effect, ursolic acid clinical manifestation have it is significant and reduce rapidly glutamic-pyruvic transaminase, serum transaminase, recession yellow subcutaneous ulcer, improve a poor appetite, Anti-fibrosis and the effect for restoring liver function, have the characteristics that quick, short treating period, effect stability." anti-hepatitis Chinese medicine is a kind of new The research and development of medicine malol and its preparation " project makes substantial progress, and is put into national " 863 " plan in 2002, obtains country 1,000,000 yuan of research fund funds, become national great research topic (2002AA2Z3217).Ursolic acid also to it is a variety of it is carcinogenic, Promoting cancer object has resistant function, and research finds that ursolic acid can obviously inhibit HL-60 cell Proliferation, and induces its apoptosis；It can make mouse The significant raising of macrophage phagocytic function, Human tongue cancer cell line strain TSCCa cell Proliferation can be inhibited, to the half of TSCCa cell The inhibition dosage of number growth is about 12.5 μm of olL-1, shows as a certain amount effect relationship interior for 24 hours；In situ hybridization is shown Ursolic acid is related with the original position expression of nuclear factor is inhibited to the inhibiting effect of TSCCa cell.In vivo studies proves ursolic acid Body's immunity can be remarkably reinforced.Illustrate that the antitumor action of ursolic acid is extensive, ursolic acid, which very likely becomes low toxicity, to be had The new anticancer drug of effect.Ursolic acid is a stronger antioxidant.There is experiment to show that ursolic acid can inhibit arachidonic acid 5-LO, peroxidase activity in metabolic process prevent prostaglandin and leukotriene from generating, this may be ursolic acid suppression The reason of inflammatory reaction processed, anti-lipid peroxidation object.Subbaramaiah etc. is research shows that ursolic acid can inhibit on human milk gland Thus the transcription of Cycloxygenase in chrotoplast also inhibits prostaglandin to generate.The antioxidation of ursolic acid resists human body Aging, skin nti-freckle, pigment of dispelling have positive effect；Antibacterial, anti-inflammatory and antiviral, it is real that Tapondjou etc. passes through acetic acid twisting It tests with hot plate method it is experimentally confirmed that ursolic acid has similar antiinflammatory and bacteriostatic functions with hydroxyursolicacid.Ursolic acid can inhibit first respectively The generation of the superoxides of acyl methionyl-leucyl-phenylalanine (fMLP) and arachidonic acid-induction.By ursolic acid and FMLP is added in cell culture fluid, and ursolic acid is in the 45ku protein tyrosine phosphatase that dose-dependent inhibition is induced by fMLP. Ursolic acid also has trypanocidal activity, and after 2 h are incubated under the concentration of 2gL, the activity of schizotrypanum cruzi flagellated body is pressed down completely System；Reducing blood lipid, antiatherosclerosis, the effect for reducing blood glucose: ursolic acid can reduce rabbit and rat cholesterolemia (44%) and B- lipoprotein levels (50%), there is reducing blood lipid, study of anti-atherogenic effect.Ursolic acid can improve dyslipidemia The caused deficiency of liver-yin and kidney-yin, tinnitus, dry, few bedroom, irritable, limb fiber crops are cold, just diseases, the blood lipid curative effect total effective rate such as knot are 95% .To the inhibiting effect of AIDS virus: human immunodeficiency virus (HIV) is Immune Deficiency Syndrome (AIDS) virulence factor.Ursolic acid has strong inhibiting effect to HIV-1 proteinase activity to field English etc. through clinical trials, Its 50% inhibition concentration (IC50) is 8 μm of ol/L.HIV-1 protease is a homodimer enzyme, and ursolic acid may be by The dimerization of HIV-1 protease is inhibited to be used to inhibit the activity of HIV-1 protease, so that hiv protease be inhibited to play a role.Bear Tartaric acid Central nervous system has apparent stable and cooling effect.
Crocin (Crocin) is the ester that crocetin and two molecule gentiobioses are combined into, and contains crocetin Dimethyl ester, Picrocrocin about 2%, volatile oil 0.4~1.3%.Pharmacological action: cholagogue.
Kaempferol, yellow fine powder.Kaempferol belongs to flavonols, yellow needles, 276 DEG C of -278 DEG C of kaempferia galangas of fusing point Phenol is slightly soluble in water, is dissolved in hot ethanol, ether and alkali.Pharmacological action: antibacterial, to staphylococcus aureus and Pseudomonas aeruginosa, typhoid fever bar Bacterium, shigella dysenteriae have inhibiting effect.Bronchitis is treated in cough-relieving.Press down enzyme, inhibits eye aldose reductase, be conducive to diabetes The treatment of cataract.It can inhibit lymphopoiesis when concentration is 1 × 10-4mol/L with mutagens activity.It is main to use In anticancer, inhibit fertility, anti-epileptic, anti-inflammatory, antioxidant, spasmolysis, antiulcer, cholagogue diuretics, cough-relieving.Kaempferol has anti- Cancer inhibits fertility, anti-epileptic, anti-inflammatory, antioxidant, spasmolysis, antiulcer, cholagogue diuretics, cough-relieving and other effects.
Prescription analysis: in above-mentioned prescription, oxtongue, flavour of a drug are bitter, cool in nature, rough, heat-clearing, detoxify, and detumescence is killed " viscous ", relieve pain, With antibacterial, there is the Kaempferol of inhibiting effect to control for we staphylococcus aureus and Pseudomonas aeruginosa, typhoid bacillus, shigella dysenteriae The main ingredient for treating asthma is aided with Banlangen increasing leukocyte number, reinforces immunity of organisms, the further antibacterial of alantolactone, bear Tartaric acid Central nervous system has the ursolic acid of apparent stable effect to alleviate the complication such as asthma bring palpitaition, crocin Cholagogue is used to alleviate asthma bring complication.Said medicine complements each other, co-therapies asthma.
Experimental example brief introduction:
Since 2010, on the basis of not finding toxic side effect by toxicological experiment, a large amount of clinic trial is carried out, has been taken Obtained satisfied curative effect.Experimental conditions are as follows:
Diagnostic criteria: " diagnostic criteria of bronchial asthma " (the China's knot formulated referring to Chinese Medical Association's respirology meeting branch Core and breathing magazine, 2003,26(3): 132) and " Mongolian medicine's Illnesses Diagnoses criterion of therapeutical effect " (Beijing: Nationalities Press, 2007: 420-421).
Criterion of therapeutical effect: referring to the curative effect mark for the bronchial asthma that Chinese Medical Association's respirology meeting branch's asthma group is formulated Standard is drafted.Clinic control: patient's asthma symptoms complete incidence graph, and 80% or more of the reachable predicted value of FEVI (respiratory capacity), or exhale 15% or less gas peak flow velocity diurnal fluctuation；It is effective: patient's asthma attack with it is substantially reduced before treatment, and FEVI is in predicted value Between 60% -79% or End--tidal PCO_2 diurnal fluctuation is between 15% -20%；Improve: patient's asthma symptoms mitigate, but FEVI Predicted value 60% hereinafter, or End--tidal PCO_2 diurnal fluctuation 20% or more；It is invalid: the clinical symptoms and FEVI of patient, or The equal no significant improvement or aggravation of climacteric flow velocity.
Since 2010, clinic aspiration asthmatic patient 40, male 20, women 20, the age at 26-70 years old, the course of disease 1-10 years, take drug of the present invention, 0.5-1.5g(amount containing main ingredient)/time, it 3 times a day, takes 3 course for the treatment of, a course for the treatment of 15 days, The good medicine of disease stops.Experimental result is shown in the following table 1:
Clinic control rate=[clinic control (example)/sum (example)] * 100%
Obvious effective rate=[effective (example)/total (example)] * 100%
Improvement rate=[improve (example)/total (example)] * 100%
Total effective rate=[total (example)-is invalid (example)] * 100%
By table as it can be seen that there is good curative effect with drug therapy asthma of the present invention.
The above-mentioned patient of follow-up 1 year, without any toxicity, more after recidivist 2 people, led by enviromental allergen stimulation It causes.
Second of embodiment:
On the basis of the first embodiment, the raw material medicaments in part by weight is added: 5-7 parts of fructus choerospondiatis, 5-7 parts of falsespiraea tree bark, 9-11 parts of Inula britannica chinensis, 5-7 parts of myrobalan.That is 10-15 parts of oxtongue, 0.5-0.7 part of Banlangen, alantolactone 0.06- 0.08 part, 0.5-0.7 part of ursolic acid, 1-2 parts of crocin, 0.05-0.07 part of Kaempferol, 5-7 parts of fructus choerospondiatis, falsespiraea tree bark 5-7 parts, 9-11 parts of Inula britannica chinensis, 5-7 parts of myrobalan.It is preferred that 12.5 parts of oxtongue, 0.6 part of Banlangen, alantolactone It 0.07 part, 0.6 part of ursolic acid, 1.5 parts of crocin, 0.06 part of Kaempferol, 6 parts of fructus choerospondiatis, 6 parts of falsespiraea tree bark, 10 parts of Inula britannica chinensis, scolds 6 parts of son.
Preparation method: crushed 80 meshes for the bulk pharmaceutical chemicals, mixes, powder or water-bindered pill agent or tablet is made.It is preferred that water Ball.
Instructions of taking: oral, the amount of adult 1-2g(amount containing main ingredient — that is, the drug in addition to auxiliary material)/time, take daily 2-3 It is secondary.
Bulk pharmaceutical chemicals brief introduction:
Fructus choerospondiatis, such as very-Chinese herbaceous peony is husky, peaceful Chinese herbaceous peony is husky, pearl as looked into a bar loud, high-pitched sound very much for Mongolian name pearl.For Anacardiaceae plant Spondias axillaris The drying fruit stone of (Choerospondias axillaris<Roxb.>Burtt et Hill).Sample it is sour, sweet, mild-natured, greasy, It is heavy, soft.The effect of having clearing away the heart-fire, improving heart function.For heart shouting pain, angina pectoris, heart failure disease etc..
Pearl does also known as falsespiraea tree bark, and Mongolian name Bo Rele gigue is slow, and different name, which is done, reaches loud, high-pitched sound day, cold-black day Gus of A Ersi, For the stem of rosaceous plant library leaf raspberry.Sweet in flavor, micro-pungent, it is mild-natured, it imitates soft.Major function: refining epidemic disease heat, cough-relieving, conditioning engine body. Cure mainly warm disease initial stage heat, intermal comflict heat, flu, oldness lung heat, coughing with a lot of sputum, asthma etc..
Inula britannica chinensis, from the drying of compositae plant Inula britannica chinensis Thunb. or Inula britannica Inula bntannica L. Capitulum.Chemical component: 1. flavonoids: Quercetin, quercimeritrin, Isoquercitrin, quercetagitrin, luteolin, Mongolian oak Pi Su-7-glucuronic acid glycoside etc..2. organic acid: P-hydroxybenzoic acid, protocatechuic acid, the blue acid of fragrant first, syringic acid, P-hydroxyphenylaceticacid, p-coumaric acid, caffeic acid, ferulic acid, salicylic acid.3. esters: 3/3,16/3-dihydroxy lupeol-3 The neat pier -13 (18) of palmitate-alkene -3- acetic acid esters, Sesquiterpene etc..4. other: table is without bridle alcohol armomadendrin, paddy steroid Base -3- glycoside etc..
Myrobalan, Mongolian name arrara, must circle it is refined, A Malida, volume wood mattress is cried out, Da Lalaha, it is old it is emerging not.For combretaceae Plant myrobalan (Terminalia chebula Retz), villus myrobalan (Terminalia chebula Retz.Var.tomentella Kurt), Henghe myrobalan (Terminalia chebula Retz.Var.gengetica Roxb dry mature fruit).(up to 20% -40%) containing a large amount of tannins, myrobalan mainly contains triterpene acids, nutgall acyl grape The substances such as sugar, the simple ester type compound of nutgall acyl and Anthraquinones have the pharmacology such as antibacterial, heart tonifying, anti-oxidant and anticancer living Property.Its main component is chebulinic acid, terchebin etc..This product puckery, it is mild-natured.There are all diseases caused by three numbness, improves voxel I.e. three, the effect of removing toxic substances, it is suitable for conspicuous according to, Xi La, Ba Dagan complication and all diseases of polymerism.
Prescription analysis: it in above-mentioned prescription, joined on the basis of the first embodiment: falsespiraea tree bark, Inula britannica chinensis, fructus choerospondiatis, Myrobalan, wherein falsespiraea tree bark, Inula britannica chinensis, further enhance the cough-relieving of prescription, the function of sending down abnormally ascending, further treat asthma, are added Fructus choerospondiatis auxiliary ursolic acid further alleviate the complication such as asthma bring palpitaition, myrobalan is used to coordinating the drug actions of a prescription.Said medicine phase It is auxiliary to coordinate, co-therapies asthma.
Experimental example brief introduction:
Since 2010, on the basis of not finding toxic side effect by toxicological experiment, a large amount of clinic trial is carried out, has been taken Obtained satisfied curative effect.Experimental conditions are as follows:
Diagnostic criteria: " diagnostic criteria of bronchial asthma " (the China's knot formulated referring to Chinese Medical Association's respirology meeting branch Core and breathing magazine, 2003,26(3): 132) and " Mongolian medicine's Illnesses Diagnoses criterion of therapeutical effect " (Beijing: Nationalities Press, 2007: 420-421).
Criterion of therapeutical effect: referring to the curative effect mark for the bronchial asthma that Chinese Medical Association's respirology meeting branch's asthma group is formulated Standard is drafted.Clinic control: patient's asthma symptoms complete incidence graph, and 80% or more of the reachable predicted value of FEVI (respiratory capacity), or exhale 15% or less gas peak flow velocity diurnal fluctuation；It is effective: patient's asthma attack with it is substantially reduced before treatment, and FEVI is in predicted value Between 60% -79% or End--tidal PCO_2 diurnal fluctuation is between 15% -20%；Improve: patient's asthma symptoms mitigate, but FEVI Predicted value 60% hereinafter, or End--tidal PCO_2 diurnal fluctuation 20% or more；It is invalid: the clinical symptoms and FEVI of patient, or The equal no significant improvement or aggravation of climacteric flow velocity.
Since 2010, clinic aspiration asthmatic patient 39, male 19, women 20, the age at 26-70 years old, the course of disease 1-10 years, take drug of the present invention, 1-2g(amount containing main ingredient)/time, it 3 times a day, takes 3 course for the treatment of, a course for the treatment of 15 days, disease is good Medicine stops.Experimental result is shown in the following table 2:
Clinic control rate=[clinic control (example)/sum (example)] * 100%
Obvious effective rate=[effective (example)/total (example)] * 100%
Improvement rate=[improve (example)/total (example)] * 100%
Total effective rate=[total (example)-is invalid (example)] * 100%
By table as it can be seen that there is good curative effect with drug therapy asthma of the present invention.Clinic control rate, total effective rate are above first Kind of embodiment, it is seen that added fructus choerospondiatis, falsespiraea tree bark, Inula britannica chinensis, myrobalan enhance the effect of prescribed treatment asthma.
The above-mentioned patient of follow-up 1 year, without any toxicity, more after recidivist 2 people, led by enviromental allergen stimulation It causes.
The third embodiment:
On the basis of second of embodiment, the raw material medicaments in part by weight is added: 5-7 parts of Radix picrorrhizae, common bombax flower 5-7 Part, 9-11 parts of nutmeg, 9-11 parts, 6-8 parts of Fructus meliae toosendan of vomiting nut (system).That is: 10-15 parts of oxtongue, Banlangen 0.5-0.7 part, 0.06-0.08 part of alantolactone, 0.5-0.7 part of ursolic acid, 1-2 parts of crocin, Kaempferol 0.05-0.07 part, 5-7 parts of fructus choerospondiatis, 5-7 parts of falsespiraea tree bark, 9-11 parts of Inula britannica chinensis, 5-7 parts of myrobalan, 5-7 parts of Radix picrorrhizae, wood 5-7 parts of cotton, 9-11 parts of nutmeg, 9-11 parts, 6-8 parts of Fructus meliae toosendan of vomiting nut (system).It is preferred that 12.5 parts of oxtongue, it is bitter 0.6 part of total alkali of ginseng, 0.07 part of alantolactone, 0.6 part of ursolic acid, 1.5 parts of crocin, 0.06 part of Kaempferol, 6 parts of fructus choerospondiatis, 6 parts of falsespiraea tree bark, 10 parts of Inula britannica chinensis, 6 parts of myrobalan, 6 parts of Radix picrorrhizae, 6 parts of common bombax flower, 10 parts of nutmeg, 10 parts of vomiting nut (system), river 7 parts of chinaberry.
Preparation method: crushed 80 meshes for the bulk pharmaceutical chemicals, mixes, powder or water-bindered pill agent or tablet is made.It is preferred that water Ball.
Instructions of taking: oral, adult 1.5-2.0g(amounts containing main ingredient)/time, it takes daily 2-3 times.
Bulk pharmaceutical chemicals brief introduction:
Alias: Radix picrorrhizae cuts lonely dew pool, Hu Lian, Tibet picrorhiza rhizome, is the root of scrophulariaceae Tibet picrorhiza rhizome and Radix picrorrhizae Stem.Latin name PicrorhizascrophulariifloraPennell.Main component: root contains kutkin (Kutkin), D- Mannitol (D-Mannitol), vanillic acid (Vanillic acid), kutkinol (Kutkiol), kutkisterol (Kutkisterol) and acetovanilone (Apocynin), still isolate bitter principle kutkin I (Picroside I), Piperonyl methyl acetone, III, of kutkin still analyse to obtain cinnamoyl-α-D- glucopyranose (Cinnamoyl- α-D- ) and 6- cinnamoyl-β-D- glucopyranose (6-Cinnamoyl- β-D-gluco- pyranose) glucopyranose.It is recklessly yellow Acetovanillone (Apocynine) is analysed to obtain in extract even.Radix picrorrhizae has reducing the asthenic fever, the infantile malnutrition with fever that disappears, cool blood eliminating dampness, purging fire for removing toxin Effect, the major functions: deficiency of Yin hectic fever due to yin；Hectic fever night sweat；Infant malnutrition；Damp-heat dysentery；Jaundice；It spits blood；Bleeding from five sense organs or subcutaneous tissue；Red eye, swell pain；Carbuncle swells sore Ulcer；Hemorrhoid pyogenic infections.
Common bombax flower, i.e. kapok petal, Mongolian name Mao Dun-haler it is special this, Ahmedabad Ma-Gus you, Lu Xingmaodun be-its Its lattice.For the drying petal of Bombacaceae plant kapok.This product is sweet in flavor, cool in nature, puckery, blunt.There is the effect of clearing away heart-fire, lung, hot liver.For Heart shouting pain, the cardiopyretic syndromes such as asthma.
Nutmeg, Mongolian name circle enlightening, that Ma of different name derive from the myristic seed of myristicaceae plant.Pharmacological property: acrid flavour, It is warm-natured.Imitate it is greasy, again, it is soft.Major function: suppression is conspicuous according to tune stomach fire helps digestion, whets the appetite.Heart He Yi is cured mainly, heart shouting pain faints, is nervous, Department's life is conspicuous according to disease, the diseases such as indigestion.
Vomiting nut (system), Mongolian name public affairs Ziller, Gao Jila, all wood up to gram, letter Pu Lebu.For before horse previous conviction plant horse or Dry mature seed before long seed horse.It burns and makes: taking net sand to set in pot, after generally making popular with high heat, net vomiting nut is added, constantly It stirs, scalds to taking-up when heaving and show sepia or dark-brown, weed out sand, cool, it is spare to scrape unhairing.This product bitter, cool in nature, Gently, blunt, have and relieving asthma, heat-clearing, removing toxic substances, the effect of analgesic.For thoracic dorsal shouting pain, asthma uncomfortable in chest.
Fructus meliae toosendan, Mongolian name Ba Rula, different name cloth and-Cha Gan-Mao Dunnai-crow heat.Pharmacological property: puckery, hardship, cool in nature.Effect Gently, light, dry, blunt.Major function: clear bar is assisted day up to dry, and scorching property Xieri Wusu Symptom, desinsection, analgesic, improving eyesight.Cure mainly hot association's day Black element disease, Ba Dagan assist day complication, turbid heat, new heat, old heat etc..
Prescription analysis: this prescription joined nutmeg, common bombax flower enhancing treatment asthma on the basis of second of embodiment Caused heart shouting pain, the cardiopyretic syndromes such as asthma, vomiting nut (system) are used to treat the complication thoracic dorsal shouting pain of asthma, asthma uncomfortable in chest, Hu Coptis reducing the asthenic fever, for assisting in the treatment of complication caused by the longer patient of asthma medical history-abnormal heat disease, clear bar of Fructus meliae toosendan is assisted up to dry Day, scorching property Xieri Wusu Symptom assists heat-clearing, and above-mentioned all medicines are combined with the medicine of second of embodiment, complemented each other, and co-therapies are roared Asthma.
Experimental example brief introduction:
Since 2010, on the basis of not finding toxic side effect by toxicological experiment, a large amount of clinic trial is carried out, has been taken Obtained satisfied curative effect.Experimental conditions are as follows:
Diagnostic criteria: " diagnostic criteria of bronchial asthma " (the China's knot formulated referring to Chinese Medical Association's respirology meeting branch Core and breathing magazine, 2003,26(3): 132) and " Mongolian medicine's Illnesses Diagnoses criterion of therapeutical effect " (Beijing: Nationalities Press, 2007: 420-421).
Criterion of therapeutical effect: referring to the curative effect mark for the bronchial asthma that Chinese Medical Association's respirology meeting branch's asthma group is formulated Standard is drafted.Clinic control: patient's asthma symptoms complete incidence graph, and 80% or more of the reachable predicted value of FEVI (respiratory capacity), or exhale 15% or less gas peak flow velocity diurnal fluctuation；It is effective: patient's asthma attack with it is substantially reduced before treatment, and FEVI is in predicted value Between 60% -79% or End--tidal PCO_2 diurnal fluctuation is between 15% -20%；Improve: patient's asthma symptoms mitigate, but FEVI Predicted value 60% hereinafter, or End--tidal PCO_2 diurnal fluctuation 20% or more；It is invalid: the clinical symptoms and FEVI of patient, or The equal no significant improvement or aggravation of climacteric flow velocity.
Since 2010, clinic aspiration asthmatic patient 40, male 20, women 20, the age at 26-70 years old, the course of disease 1-10 years, take drug of the present invention, 1.5-2.0g(amounts containing main ingredient)/time, it 3 times a day, takes 3 course for the treatment of, a course for the treatment of 15 days, The good medicine of disease stops.Experimental result is shown in the following table 3:
Clinic control rate=[clinic control (example)/sum (example)] * 100%
Obvious effective rate=[effective (example)/total (example)] * 100%
Improvement rate=[improve (example)/total (example)] * 100%
Total effective rate=[total (example)-is invalid (example)] * 100%
By table as it can be seen that there is good curative effect with drug therapy asthma of the present invention.Clinic control rate, obvious effective rate, total effective rate are equal Higher than second embodiment, it is seen that Radix picrorrhizae, common bombax flower, nutmeg, vomiting nut (system), the Fructus meliae toosendan of addition can be further Enhance the effect of prescribed treatment asthma.
The above-mentioned patient of follow-up 1 year, without any toxicity, more after recidivist 1 people, caused by enviromental allergen stimulation.
4th kind of embodiment: on the basis of the third embodiment, the raw material medicaments in part by weight is added: agalloch eaglewood 5-7 Part, 12-13 parts of dalbergia wood, 12-13 parts of mountain agalloch eaglewood, 9-11 parts of costus root, 9-11 parts of cloves.That is: 10-15 parts of oxtongue, it is bitter 0.5-0.7 part of total alkali of ginseng, 0.06-0.08 part of alantolactone, 0.5-0.7 part of ursolic acid, 1-2 parts of crocin, kaempferia galamga 0.05-0.07 part of phenol, 5-7 parts of fructus choerospondiatis, 5-7 parts of falsespiraea tree bark, 9-11 parts of Inula britannica chinensis, 5-7 parts of myrobalan, 5-7 parts of Radix picrorrhizae, 5-7 parts of common bombax flower, 9-11 parts of nutmeg, 9-11 parts of vomiting nut (system), 6-8 parts of Fructus meliae toosendan, 5-7 parts of agalloch eaglewood, dalbergia wood 12- 13 parts, 12-13 parts of mountain agalloch eaglewood, 9-11 parts of costus root, 9-11 parts of cloves.It is preferred that 12.5 parts of oxtongue, Banlangen 0.6 Part, 0.07 part of alantolactone, 0.6 part of ursolic acid, 1.5 parts of crocin, 0.06 part of Kaempferol, 6 parts of fructus choerospondiatis, 6 parts of falsespiraea tree bark, 10 parts of Inula britannica chinensis, 6 parts of myrobalan, 6 parts of Radix picrorrhizae, 6 parts of common bombax flower, 10 parts of nutmeg, 10 parts of vomiting nut (system), sinks by 7 parts of Fructus meliae toosendan It is 6 parts, 12.5 parts of dalbergia wood, 12.5 parts of mountain agalloch eaglewood, 10 parts of costus root, 10 parts of cloves fragrant.
Preparation method one: crushed 80 meshes for the bulk pharmaceutical chemicals, mixes, powder or water-bindered pill agent or tablet is made.It is preferred that The water-bindered pill.
Instructions of taking: oral, the amount of adult 1.5-2.5g(amounts containing main ingredient — that is, the drug in addition to auxiliary material)/time, it takes daily 2-3 times.
Preparation method two: by the agalloch eaglewood in bulk pharmaceutical chemicals, dalbergia wood, mountain agalloch eaglewood, costus root, cloves is ground into coarse powder, adds steaming Distilled water impregnates 30min, is placed in volatile oil extractor, adds water, past medicinal material liquid level 3-4cm, heating water bath, in collection The volatile oil that bulk pharmaceutical chemicals extract is stated, it is spare, then remaining drug be crushed into 80 meshes, add 75% alcohol reflux to extract 1- 2 hours, filtrate was collected in filtering, and concentration obtains concentrate, uniformly mixes with above-mentioned volatile oil, add auxiliary material, pill is made.
Instructions of taking: oral, the amount of adult 0.5-1.5g(amount containing main ingredient — that is, the drug in addition to auxiliary material)/time, it takes daily 2-3 times.
Preparation method three: by the agalloch eaglewood in bulk pharmaceutical chemicals, dalbergia wood, mountain agalloch eaglewood, costus root, cloves is ground into coarse powder, adds distillation Water impregnates 30min, is placed in volatile oil extractor, adds water, and past medicinal material liquid level 3-4cm, heating water bath is collected above-mentioned The volatile oil that bulk pharmaceutical chemicals extract, it is spare, then remaining drug be crushed into 80 meshes, to it under the conditions of first using 70 DEG C of petroleum ether It is washed, is filtered, discard filtrate, filter residue adds 75% alcohol reflux to extract 1-2 hours, and filtrate is collected in filtering, and concentration obtains Concentrate uniformly mixes with above-mentioned volatile oil, adds auxiliary material, pill is made.
Instructions of taking: oral, the amount of adult 0.5-1.5g(amount containing main ingredient — that is, the drug in addition to auxiliary material)/time, it takes daily 2-3 times.
Bulk pharmaceutical chemicals brief introduction:
Agalloch eaglewood, Mongolian name Ah loud, high-pitched sound are the timber containing resin of Isolated From Thymelaeaceae Species agalloch eaglewood or suspension culture of Aquilaria sinensis such as.Acrid flavour, hardship, it is cool in nature. It imitates heavy, soft, greasy, dry, blunt, soft.Major function: suppression is conspicuous according to, heat-clearing, only shouting pain, benefit breathing.It is hot to cure mainly the heart, heart shouting pain, palpitaition, Asthma, master pulse it is conspicuous according to.
Mountain agalloch eaglewood, Mongolian name Alxa Ah loud, high-pitched sound such as, Ao youth Ah loud, high-pitched sound is such as.For the dry duramen of Oleaceae plants Helan Mountain cloves Or root, the same agalloch eaglewood of this product nature and flavor, effect.
Dalbergia wood, such as, different name A Maer, Ah loud, high-pitched sound are pulse family such as-Gao Wude " errorless anaesthetic mirror " to Mongolian name Ulan-Ah loud, high-pitched sound The root heartwood of plant dalbergia wood wingceltis.Pharmacological property: acrid flavour, it is cool in nature.It imitates greasy.Major function: suppression is conspicuous according to heat-clearing relieves pain.It is conspicuous to cure mainly the heart According to, lifeblood is conspicuous to tremble according to disease, and dizzy, insomnia is ill at ease and full of dread, and it is conspicuous mutually to be won according to blood, it is hot between mountains and rivers.
Radix aucklandiae is the common name of compositae plant Aplotaxis auriculata and radix jurineae.Aplotaxis auriculata (scientific name: auureacotu) also known as costus root Or dutchmanspipe root, belong to composite family Genus Saussurea.Radix aucklandiae Aucklandia lappa Decne, Mongolian name such as reach, sand bubble such as reach, Ma slave Such as reach.For the dry root of compositae plant radix aucklandiae (Aucklandia lappa Decen.).This product acrid flavour, hardship, warm-natured, greasy, puckery, Gently；Dispel Ba Dagan, broken ruffian, adjusts voxel, restrains purulence, phlegm, anti-erosion, flat qi and blood is mutually won, analgesic and other effects.Radix aucklandiae containing dehydrogenation Lactone (dehydrocostuslactone), the volatile oil such as costunolide (costunolide) and a variety of amino acid.
Cloves, Mongolian name Gao Ledou-Bao Ru, different name Li Xi, Li Xisangsi " errorless anaesthetic mirror ", volume day-Gao Ledou- Treasured is eaten.From hill gooseberry can plant of clove bud.Acrid flavour, slight bitter, it is warm-natured.It imitates heavy, greasy, solid, soft, dry.Major function: dispelling It is cold, it dispels conspicuous according to fire tuning helps digestion, appetizing, removing toxic substances, table rash, throat.It is conspicuous according to, heart He Yi to cure mainly master pulse, demented, acne rash is silent.
Prescription analysis: this prescription is the addition agalloch eaglewood, dalbergia wood, mountain agalloch eaglewood, costus root, fourth on the basis of the third embodiment Perfume (or spice), this five kinds of Chinese medicine all have pungent scattered gas, and wherein agalloch eaglewood, dalbergia wood, mountain agalloch eaglewood, cloves can press down conspicuous according to heat-clearing, only shouting pain is assisted Help fructus choerospondiatis, ursolic acid further to alleviate the complication such as asthma bring palpitaition, costus root dispel Ba Dagan, adjust voxel, flat qi and blood Asthma bring pectoralgia is further alleviated in Xiang Bo, analgesic, and said medicine complements each other co-therapies asthma.
Preparation method analysis: first is that traditional anaesthetic preparation method the water-bindered pill is made in said medicine crushing by preparation method；System Preparation Method two improves preparation method, by due to the dissolubility for the effective component that effect is played in prescription it is different, according to Characteristic is first extracted the effective component of performance curative effect of agalloch eaglewood, dalbergia wood, mountain agalloch eaglewood, costus root, cloves this five kinds of Chinese medicine, There is the ingredient by the performance curative effect of remaining drug to be extracted, then again mix the two, suitable dosage form-ball is made Agent.By this preparation method, the submember for not playing main function in prescription is eliminated, the performance in prescription has been refined The ingredient of main function, specifies active component, reduces taking dose, facilitates patients, thus from another point of view indirectly Enhance the therapeutic effect of drug, expand therapeutic domain, because of anaesthetic flavour of a drug, medication dose is big, cannot adhere to taking and It refuses to take medicine, therapeutic effect reduction, therapeutic domain is caused to be substantially reduced；Preparation method three is on the basis of preparation method two to medicine The active component of object has carried out further refining, and agalloch eaglewood, dalbergia wood, mountain agalloch eaglewood, costus root, cloves five kinds of Chinese medicine are dissolved in petroleum ether Invalid components reject, keep effective component more accurate, medication dose can further decrease, and also eliminate invalid components to trouble Other ill-effects of person.
Experimental example brief introduction:
Since 2010, on the basis of not finding toxic side effect by toxicological experiment, a large amount of clinic trial is carried out, has been taken Obtained satisfied curative effect.Experimental conditions are as follows:
Diagnostic criteria: " diagnostic criteria of bronchial asthma " (the China's knot formulated referring to Chinese Medical Association's respirology meeting branch Core and breathing magazine, 2003,26(3): 132) and " Mongolian medicine's Illnesses Diagnoses criterion of therapeutical effect " (Beijing: Nationalities Press, 2007: 420-421).
Criterion of therapeutical effect: referring to the curative effect mark for the bronchial asthma that Chinese Medical Association's respirology meeting branch's asthma group is formulated Standard is drafted.Clinic control: patient's asthma symptoms complete incidence graph, and 80% or more of the reachable predicted value of FEVI (respiratory capacity), or exhale 15% or less gas peak flow velocity diurnal fluctuation；It is effective: patient's asthma attack with it is substantially reduced before treatment, and FEVI is in predicted value Between 60% -79% or End--tidal PCO_2 diurnal fluctuation is between 15% -20%；Improve: patient's asthma symptoms mitigate, but FEVI Predicted value 60% hereinafter, or End--tidal PCO_2 diurnal fluctuation 20% or more；It is invalid: the clinical symptoms and FEVI of patient, or The equal no significant improvement or aggravation of climacteric flow velocity.
Since 2010, clinic aspiration asthmatic patient 119, male 60, women 59, the age is sick at 26-70 years old Journey 1-10 years, three groups, under the same terms are randomly divided into, drug made from three kinds of preparation methods of this prescription is taken respectively, takes preparation The instructions of taking of drug made from method one: 1.5-2.5g(amounts containing main ingredient)/time, it 3 times a day, takes 3 course for the treatment of, a course for the treatment of 15 days, the good medicine of disease stopped；Take the instructions of taking of drug made from preparation method two: 0.5-1.5g(amount containing main ingredient)/time, one day 3 It is secondary, it takes 3 course for the treatment of, a course for the treatment of 15 days, the good medicine of disease stops；Take the instructions of taking of drug made from preparation method two: 0.5- 1.5g(amount containing main ingredient)/time, it 3 times a day, takes 3 course for the treatment of, a course for the treatment of 15 days, the good medicine of disease stops；Experimental result is shown in the following table 4:
Clinic control rate=[clinic control (example)/sum (example)] * 100%
Obvious effective rate=[effective (example)/total (example)] * 100%
Improvement rate=[improve (example)/total (example)] * 100%
Total effective rate=[total (example)-is invalid (example)] * 100%
By table as it can be seen that there is good curative effect with drug therapy asthma of the present invention.By above-mentioned three kinds of preparation methods to having a competition Test as it can be seen that preparation method also have a large impact on the drug effect of prescription, and preparation method three better than preparation method two due to Preparation method one, and each dose of preparation method two, three is greatly lowered compared with preparation method one, facilitates patients.
The above-mentioned patient of follow-up 1 year, without any toxicity, more after recidivist 1 people, caused by enviromental allergen stimulation.
5th kind of embodiment:
On the basis of previous embodiment, described 0.5-0.7 part of Banlangen is substituted by 5-7 parts of kuh-seng, in elecampane 0.06-0.08 part of ester is substituted by 5-6 parts of elecampane, and 0.5-0.7 part of ursolic acid, 1-2 parts of crocin by 38-42 parts of Cape jasmines Son substitution, 0.05-0.07 part of Kaempferol is substituted by 5-7 parts of kaempferia galamgas.It is preferred that on the basis of the 4th kind of embodiment, it is described 0.5-0.7 part of Banlangen is substituted by 5-7 parts of kuh-seng, and 0.06-0.08 part of alantolactone is substituted by 5-6 parts of elecampane, 0.5-0.7 part of ursolic acid, 1-2 parts of crocin are substituted by 38-42 parts of cape jasmines, and 0.05-0.07 part of Kaempferol by 5-7 parts Kaempferia galamga substitution, that is, form prescription: 10-15 parts of oxtongue, 5-7 parts of kuh-seng, and 5-6 parts of elecampane, 38-42 parts of cape jasmine, kaempferia galamga 5-7 parts, 5-7 parts of fructus choerospondiatis, 5-7 parts of falsespiraea tree bark, 9-11 parts of Inula britannica chinensis, 5-7 parts of myrobalan, 5-7 parts of Radix picrorrhizae, common bombax flower 5-7 parts, 9-11 parts of nutmeg, 9-11 parts of vomiting nut (system), 6-8 parts of Fructus meliae toosendan, 5-7 parts of agalloch eaglewood, 12-13 parts of dalbergia wood, 12-13 parts of mountain agalloch eaglewood, 9-11 parts of costus root, 9-11 parts of cloves.
Preparation method one: crushed 80 meshes for the bulk pharmaceutical chemicals, mixes, powder or water-bindered pill agent or tablet is made.It is preferred that The water-bindered pill.
Instructions of taking: oral, the amount of adult 2-3g(amounts containing main ingredient — that is, the drug in addition to auxiliary material)/time, take daily 2-3 It is secondary.
Preparation method two: by the agalloch eaglewood in bulk pharmaceutical chemicals, dalbergia wood, mountain agalloch eaglewood, costus root, cloves is ground into coarse powder, adds steaming Distilled water impregnates 30min, is placed in volatile oil extractor, adds water, past medicinal material liquid level 3-4cm, heating water bath, in collection The volatile oil that bulk pharmaceutical chemicals extract is stated, it is spare, then remaining drug be crushed into 80 meshes, add 75% alcohol reflux to extract 1- 2 hours, filtrate was collected in filtering, and concentration obtains concentrate, uniformly mixes with above-mentioned volatile oil, add auxiliary material, pill is made.
Instructions of taking: oral, adult 1.0-1.5g(amounts containing main ingredient)/time, it takes daily 2-3 times.
Preparation method three: by the agalloch eaglewood in bulk pharmaceutical chemicals, dalbergia wood, mountain agalloch eaglewood, costus root, cloves is ground into coarse powder, adds distillation Water impregnates 30min, is placed in volatile oil extractor, adds water, and past medicinal material liquid level 3-4cm, heating water bath is collected above-mentioned The volatile oil that bulk pharmaceutical chemicals extract, it is spare, then remaining drug be crushed into 80 meshes, to it under the conditions of first using 70 DEG C of petroleum ether It is washed, is filtered, discard filtrate, filter residue adds 75% alcohol reflux to extract 1-2 hours, and filtrate is collected in filtering, and concentration obtains Concentrate uniformly mixes with above-mentioned volatile oil, adds auxiliary material, pill is made.
Instructions of taking: oral, adult 1.0-1.5g(amounts containing main ingredient)/time, it takes daily 2-3 times.
Bulk pharmaceutical chemicals brief introduction:
Kuh-seng, Mongolian name road bone Le-Wu Busi, Li Derui.For leguminous plant kuh-seng (Sophora flavescens Ait.) Dry root.Containing alkaloid: matrine (matrine), oxymatrine, the alkaloid compounds such as Iosmatrine.Bitter, property It is flat, greasy, soft.Have and promote hot maturation, sweating, dry yellow water, reconcile three the effect of.It is such as hit by stick for overall pain, dry cough is breathed out It owes more, often stretches oneself, bitter taste, headache, the unformed heat symptom-complex such as palpitaition, epidemic disease: flu does, dutchmanspipe root, kaempferia galamga etc. are matched with pearl With.
Elecampane: its its lattice of anaesthetic name Ma Nu, different name Ma Nubadala, Gao You-haler De Situ-.From composite family The root of plant elecampane.Pharmacological property: it is sweet in flavor, bitter, pungent, it is mild-natured.It imitates greasy, sharp, dry, again.Major function: clear bar reaches xeothermic, Xie Heyi Blood phase intermal comflict, middle benefit gas help digestion, appetizing, only shouting pain.Cold headache is cured mainly, pernicious shiver with cold is conspicuous to cause asthma uncomfortable in chest according to blood phase intermal comflict, vomiting Sour regurgitation, He Yixi headache and blood-head headache.Chemical component: contain synanthrin, volatile oil, oil in main component be in elecampane Ester, isoalantolactone, alantol etc..
Cape jasmine, Mongolian name pearl such as drawing, Gao Mosile.For the dry fruit of madder wort cape jasmine.Pharmacological property: bitter, cool in nature, It is blunt, puckery.There is the effect of removing heat from blood, improving eyesight, the Ba Dagan that dispels is uncommon to be drawn, and nourishing is strong and adjusts voxel.For liver heat, appearance jaundice blood Heat, bladder heat etc..It is downloaded from " Chinese pharmacy encyclopedia ".Alias: Yellow Fructus Gardeniae, mountain Cape jasmine, white toad are the fruits of madder wort cape jasmine It is real.Constituents containing iridoid: gardenoside (gardenoside), all square rafter glucoside (geniposide), all square rafter element gentiobiose Glucoside (genipin-1-gentiobioside), shanzhiside (shanzhiside), cape jasmine ketone glucoside (gardo-side), Paederia scandens Glucoside methyl esters (scandoside methyl ester), all square rafter glucoside (geniposidic acid), deacetylate asperuloside Sour (deacetyl asperulosidic acid), deacetylasperulosidic acid methyl esters (methyl deacetyl Asperulosidate), 6 〃 of 10- acetyl group all square rafter glucoside (10-acetylgeniposide)-is to coumaric acyl square rafter elements Gentiobiose glucoside (6 〃-p-coumaroyl genipin gentiobio-side).Contain acrylic component: chlorogenic acid again (chlorogenic acid), its quininic acid (3, -4-di-O-caffeoyl quinic acid) of 3,4- bis--O- caffeoyls, 3- O- coffee acyl -4-O- mustard acyl quininic acid (3-O-caffeoyl-4-O-sinapoyl quinic acid), 3,5- bis- - O- coffee acyl -4-O- (- 3 methyl of 3- hydroxyl) glutaryl quininic acid [3,5-di-O-caffeoyl-4-O- (3-hydroxy- 3-methyl) glutaroyl quinic acid], 3,4- bis- coffee acyl -5- (3- hydroxy-3-methyl glutaryl base) quinine Sour [3,4-dicaffeovl-5- (3-hydroxy-3-methyl glutaroyl) quinic acid], crocetin (cro- Cetin), crocin (crocin), ursolic acid (ursolic acid), crocin glycoside (crocin Glucoside) etc..Also contain flavones ingredient: rutin (rutin) and PEARLITOL 25C (D-mannitol), cupreol (β- Sitosterol), choline (choline), nonacosane (nonacosane), lutein (xanthophyll) etc..Pericarp and kind Also contain gardenoside, all square rafter glucoside, all square rafter glucoside, all square rafter in son.Flower contains Triterpenoid: gardenia acid (gradenlic acid) A, B and gardenia acid (gardenic acid) leaf contain gardenoside, all square rafter glucoside, cape jasmine aldehyde (cerbinal), dihydrojasmonate (methyl dihydrojasmonate), acetic acid benzyl lemon imonene (limonene), fragrant camphor tree Alcohol (linalool) etc..Rhizome contains PEARLITOL 25C, oleanolic acid (oleanolic acid), stigmasterol (sing-masterol). It is bitter in taste, cold, nontoxic.With purging intense heat relieving restlessness, reducing fever and causing diuresis, swelling and pain relieving, cooling blood and hemostasis, protect liver, cholagogue, decompression, calmness, only The effects of blood, detumescence.It is usually used in treating icteric hepatitis, headache in tcm clinical practice；Jaundice with damp-heat pathogen；Stranguria；Bloody flux hematuria；Dispute Raw sore；Sore swollen toxin；The diseases such as bruise, hypertension, diabetes.
Kaempferia galamga, alias: husky ginger, three a kind of apples, mountain are peppery, perennial herb, be Zingiber kaempferia galanga platymiscium kaempferia galanga ( Kaempferia galanga Linn.) rhizome, kaempferia galamga volatile oil, Kaempferol are contained in kaempferia galamga.Anaesthetic name Cha Gan-loud, high-pitched sound, For the rhizome of zingiberaceous plant kaempferia galamga Kaemp feria galangal L..Pharmacological property: acrid flavour, hardship, puckery, property is hot.Imitate it is light, sharp, dry, It is rough.Major function: except Ba Dagan is conspicuous according to, middle benefit gas, stagnation resolvation.Cure mainly indigestion, stomach trouble, nausea, extravesated blood stasis of blood hematocele ruffian etc..
Prescription analysis: in this prescription, on the basis of previous embodiment, the Banlangen is substituted by kuh-seng, soil Constuslactone is substituted by elecampane, and ursolic acid, crocin are substituted by cape jasmine, and Kaempferol is substituted by kaempferia galamga, this prescription purpose is Under the premise of basic holding drug effect, drug cost is reduced, is replaced to drug dispensing with bulk pharmaceutical chemicals.
Preparation method analysis: first is that traditional anaesthetic preparation method the water-bindered pill is made in said medicine crushing by preparation method；System Preparation Method two improves preparation method, by due to the dissolubility for the effective component that effect is played in prescription it is different, according to Characteristic is first extracted the effective component of performance curative effect of agalloch eaglewood, dalbergia wood, mountain agalloch eaglewood, costus root, cloves this five kinds of Chinese medicine, There is the ingredient by the performance curative effect of remaining drug to be extracted, then again mix the two, suitable dosage form-ball is made Agent.By this preparation method, the submember for not playing main function in prescription is eliminated, the performance in prescription has been refined The ingredient of main function, specifies active component, reduces taking dose, facilitates patients, thus from another point of view indirectly Enhance the therapeutic effect of drug, expand therapeutic domain, because of anaesthetic flavour of a drug, medication dose is big, cannot adhere to taking and It refuses to take medicine, therapeutic effect reduction, therapeutic domain is caused to be substantially reduced；Preparation method three is on the basis of preparation method two to medicine The active component of object has carried out further refining, and agalloch eaglewood, dalbergia wood, mountain agalloch eaglewood, costus root, cloves five kinds of Chinese medicine are dissolved in petroleum ether Invalid components reject, keep effective component more accurate, medication dose can further decrease, and also eliminate invalid components to trouble Other ill-effects of person.
Experimental example brief introduction:
Since 2010, on the basis of not finding toxic side effect by toxicological experiment, a large amount of clinic trial is carried out, has been taken Obtained satisfied curative effect.Experimental conditions are as follows:
Diagnostic criteria: " diagnostic criteria of bronchial asthma " (the China's knot formulated referring to Chinese Medical Association's respirology meeting branch Core and breathing magazine, 2003,26(3): 132) and " Mongolian medicine's Illnesses Diagnoses criterion of therapeutical effect " (Beijing: Nationalities Press, 2007: 420-421).
Criterion of therapeutical effect: referring to the curative effect mark for the bronchial asthma that Chinese Medical Association's respirology meeting branch's asthma group is formulated Standard is drafted.Clinic control: patient's asthma symptoms complete incidence graph, and 80% or more of the reachable predicted value of FEVI (respiratory capacity), or exhale 15% or less gas peak flow velocity diurnal fluctuation；It is effective: patient's asthma attack with it is substantially reduced before treatment, and FEVI is in predicted value Between 60% -79% or End--tidal PCO_2 diurnal fluctuation is between 15% -20%；Improve: patient's asthma symptoms mitigate, but FEVI Predicted value 60% hereinafter, or End--tidal PCO_2 diurnal fluctuation 20% or more；It is invalid: the clinical symptoms and FEVI of patient, or The equal no significant improvement or aggravation of climacteric flow velocity.
Since 2010, clinic aspiration asthmatic patient 118, male 58, women 60, the age is sick at 26-70 years old Journey 1-10 years, three groups, under the same terms are randomly divided into, drug made from three kinds of preparation methods of this prescription is taken respectively, takes preparation The instructions of taking of drug made from method one: 2-3g(amounts containing main ingredient)/time, it 3 times a day, takes 3 course for the treatment of, a course for the treatment of 15 days, The good medicine of disease stops；Take the instructions of taking of drug made from preparation method two: 1.0-1.5g(amounts containing main ingredient)/time, 3 times a day, clothes With 3 courses for the treatment of, a course for the treatment of 15 days, the good medicine of disease stops；Take the instructions of taking of drug made from preparation method two: 1.0-1.5g(contain Main ingredient amount)/time, it 3 times a day, takes 3 course for the treatment of, a course for the treatment of 15 days, the good medicine of disease stops；Experimental result is shown in the following table 5:
Clinic control rate=[clinic control (example)/sum (example)] * 100%
Obvious effective rate=[effective (example)/total (example)] * 100%
Improvement rate=[improve (example)/total (example)] * 100%
Total effective rate=[total (example)-is invalid (example)] * 100%
By table as it can be seen that the clinic control rate of the present embodiment, total effective rate differ 1-4 percentages not as good as the 4th kind of embodiment Point, under the premise of saving raw material, be using the method that bulk pharmaceutical chemicals are replaced to drug dispensing it is feasible, improve cost performance.
The above-mentioned patient of follow-up 1 year, without any toxicity, more after recidivist 1 people, caused by enviromental allergen stimulation.

Claims (10)

1. a kind of anaesthetic for treating asthma, it is characterised in that: the anaesthetic includes the bulk pharmaceutical chemicals of following parts by weight: oxtongue 10- 15 parts, 0.5-0.7 part of Banlangen, 0.06-0.08 part of alantolactone, 0.5-0.7 part of ursolic acid, crocin 1-2 Part, 0.05-0.07 part of Kaempferol.
2. a kind of anaesthetic for treating asthma according to claim 1, it is characterised in that: the raw material medicaments in part by weight adds Enter: 5-7 parts of fructus choerospondiatis, 5-7 parts of falsespiraea tree bark, 9-11 parts of Inula britannica chinensis, 5-7 parts of myrobalan.
3. a kind of anaesthetic for treating asthma according to claim 2, it is characterised in that: the raw material medicaments in part by weight adds Enter: 5-7 parts of Radix picrorrhizae, 5-7 parts of common bombax flower, 9-11 parts of nutmeg, 9-11 parts, 6-8 parts of Fructus meliae toosendan of vomiting nut (system).
4. a kind of anaesthetic for treating asthma according to claim 3, it is characterised in that: the raw material medicaments in part by weight adds Enter: 12-13 parts of agalloch eaglewood, 12-13 parts of dalbergia wood, 12-13 parts of mountain agalloch eaglewood, 9-11 parts of costus root, 9-11 parts of cloves.
5. a kind of conspicuous anaesthetic according to analgesic of relievining asthma of suppression described in any one according to claim 1-4, it is characterised in that: institute 0.5-0.7 part of the Banlangen stated is substituted by 5-7 parts of kuh-seng, and 0.06-0.08 part of alantolactone is replaced by 5-6 parts of elecampane Generation, 0.5-0.7 part of ursolic acid, 1-2 parts of crocin are substituted by 38-42 parts of cape jasmines, and 0.05-0.07 part of Kaempferol by 5-7 Part kaempferia galamga substitution.
6. a kind of preparation method for the anaesthetic for treating asthma, feature described in any one according to claim 1-4 exist In: the bulk pharmaceutical chemicals be crushed into 80 meshes, mix, powder or water-bindered pill agent or tablet is made.
7. a kind of preparation method of anaesthetic for treating asthma according to claim 5, it is characterised in that: by the bulk pharmaceutical chemicals It crushed 80 meshes, mix, powder or water-bindered pill agent or tablet is made.
8. a kind of preparation method of anaesthetic for treating asthma according to claim 4, it is characterised in that: will be in bulk pharmaceutical chemicals Agalloch eaglewood, dalbergia wood, mountain agalloch eaglewood, costus root, cloves is ground into coarse powder, adds distilled water, impregnates 30min, is placed in volatile oil extractor In, add water, past medicinal material liquid level 3-4cm, heating water bath collects the volatile oil that above-mentioned raw materials medicine extracts, and it is spare, then Remaining drug be crushed into 80 meshes, 75% alcohol reflux is added to extract 1-2 hours, filtrate is collected in filtering, and concentration must be concentrated Object uniformly mixes with above-mentioned volatile oil, adds auxiliary material, pill is made.
9. a kind of preparation method of anaesthetic for treating asthma according to claim 5, it is characterised in that: will be in bulk pharmaceutical chemicals Agalloch eaglewood, dalbergia wood, mountain agalloch eaglewood, costus root, cloves is ground into coarse powder, adds distilled water, impregnates 30min, is placed in volatile oil extractor In, add water, past medicinal material liquid level 3-4cm, heating water bath collects the volatile oil that above-mentioned raw materials medicine extracts, and it is spare, then Remaining drug be crushed into 80 meshes, 75% alcohol reflux is added to extract 1-2 hours, filtrate is collected in filtering, and concentration must be concentrated Object uniformly mixes with above-mentioned volatile oil, adds auxiliary material, pill is made.
10. a kind of preparation method of anaesthetic for treating asthma according to claim 5, it is characterised in that: will be in bulk pharmaceutical chemicals Agalloch eaglewood, dalbergia wood, mountain agalloch eaglewood, costus root, cloves is ground into coarse powder, adds distilled water, impregnates 30min, is placed in volatile oil extractor In, add water, past medicinal material liquid level 3-4cm, heating water bath collects the volatile oil that above-mentioned raw materials medicine extracts, and it is spare, then Remaining drug be crushed into 80 meshes, first with being washed to it under the conditions of 70 DEG C of petroleum ether, filter, discard filtrate, filter residue adds 75% alcohol reflux extracts 1-2 hours, filtering, collects filtrate, and concentration obtains concentrate, uniformly mixes, add with above-mentioned volatile oil Pill is made in auxiliary material.
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