CN104873778A - Otitis media treatment drops and preparation method - Google Patents
Otitis media treatment drops and preparation method Download PDFInfo
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Abstract
The invention discloses otitis media treatment drops and a preparation method. The raw materials of the drops include 11 to 15 parts of Chinese trichosanthes, 9 to 13 parts of common andrographis, 7 to 16 parts of carnose goldsaxifrage herb, 10 to 14 parts of semen benincasae, 8 to 15 parts of broadleaf ainsliaea herb, 6 to 12 parts of long stephania herb with root, 8 to 13 parts of acorus gramineus soland, 10 to 15 parts of cotton rose hibiscus leaf, 7 to 14 parts of starfish, 9 to 15 parts of clavateleaf oberonia herb, 8 to 16 parts of Chinese knotweed herb, 10 to 13 parts of common jasminorange, 7 to 16 parts of resina populi, 9 to 12 parts of divaricate carpesium herb, 11 to 14 parts of selfheal and 10 to 12 parts of pomegranate flower. The drops have the advantages of anti-bacterial, anti-viral, deswelling and pus expelling functions, the thoroughly healing effect of redness and swelling of different extents are provided for ear tympanums particularly, the raw materials interact in a compounded manner, and the drops further have the advantages of significant curative effect, safety, convenience and low cost.
Description
Technical field
The present invention relates to traditional Chinese medicine field, particularly relate to a kind of drop and method for making for the treatment of otitis media.
Background technology
Otitis media is commonly called as " rotten ear ", is the inflammation of mucosa of tympanic cavity.It shows as in ear pain (night increases the weight of), heating, aversion to cold, auditory dysesthesia etc.Otitis media is with body constitution, climate change, and in ear can regularly be suppurated liquid, time many time few, delay is for many years.Primary disease is most common sympton with the vexed swollen sense of in ear or blocking sense, auditory dysesthesia and tinnitus.After often betiding flu, or occur unconsciously.Sometimes head position variation can feel hearing improved.Some patients has slight otalgia.Child often shows as obedient blunt or absent minded.Otitis media has suppurative with apyetous two class, and apyetous person comprises secretory otitis media, barotraumatic otits media etc., and suppurative person has acute and chronic point.Specific inflammatory is shown in very little, as tuberculous otitis media etc.Chronic suppurative otitis media has pure again, cholesteatoma type and three kinds, caries type.Apyetous and pure suppurative otitis media are in general still safer, and serious complication can not occur.But various complication can be there is, if intracranial complication just has harm in cholesteatoma type and two kinds, caries type.
Primary disease is called " otopyosis ", " chronic suppurative otitis media " by the traditional Chinese medical science, thinks because of dampness-heat in the liver and gallbladder, and pathogen is prevailing draws.Chinese traditional treatment otitis media have deficiency and excess point, the cardinal symptom of excess syndrome is that in ear feeling of distension and oppression, otalgia, red complexion are red, auditory dysesthesia, tinnitus, auditory meatus pus Huang is thick, is more common in acute suppurative otitis media.
Application publication number CN 104257814 A(application number 201410470976.5) Chinese invention patent document disclose a kind of medicine for the treatment of otitis media, be prepared from by the raw material of following weight portion: Herba Hedyotidis Diffusae 2-6g, draw together Scolopendra one, Periostracum Serpentis 3-8g, Faeces Vespertilionis 2-6g, Fructus Psoraleae 10-20g, Thallus Laminariae (Thallus Eckloniae) 3-8g, cotton seed 5-10g, Herba Epimedii 4-8g, Flos Lonicerae 10-20g, Fructus Forsythiae 5-12g and glycerol 10-24g.Application publication number CN 103191213 A(application number 201310154572.0) Chinese invention patent document disclose a kind of Chinese medicine for the treatment of otitis media, be made up of the raw material of following parts by weight: wine Scorpio 2-4 part, stir-baked SQUAMA MANITIS 2-4 part, prepared PERIOSTRACUM SERPENIS with vino 1-3 part, dried Alumen 2-4 part, Bombyx bombycis 1-3 part, Endoconcha Sepiae 2-4 part, Borax 2-4 part, Rhizoma Coptidis 2-4 part, Indigo Naturalis 1-3 part, Os Draconis 2-4 part, MEIHUA BINGPIAN 1-3 part.Application publication number CN 103479823 A(application number 201310445950.0) Chinese invention patent document disclose a kind of Chinese medicine preparation for the treatment of otitis media, be made up of the raw material of following parts by weight: Folium Malloti Apeltae 64-89 part; Radix Berberidis Amurensis 59-84 part; Calendula officinalis 58-84 part; Radix Seu Herba Physochlainae Physaloidis 54-79 part; Herba Pothi Chinensis 50-77 part; Herba Hydrocotyles 49-74 part; Folium Citri grandis 46-69 part; Radix abutili indici 44-65 part; Borax 44-64 part; Asteriscus Pseudosciaenae 41-60 part; Herba Andrographis 39-59 part; Flos Granati 35-52 part; Concha 34-49 part; Armillaria mella tabescens (Scop.ex Fr.) Sing. 31-47 part; Radix Rubi sumatrani 24-44 part; Herba Agerati Conyzoidis 14-34 part.
The medicine for the treatment of otitis media in prior art is all generally the mode such as Western medicine, hydrogen peroxide cleaning adopting oral anti-inflammatory type, serious treatment of performing an operation; Although adopt Western medicine to have certain therapeutic effect, but there is slow curative effect, medical expense is high, toxic and side effects is large shortcoming, therefore its result of use or not ideal enough.
Summary of the invention
For the deficiencies in the prior art, the object of this invention is to provide and a kind ofly prepare simple, taking convenience, the drop for the treatment of otitis media safely and effectively and method for making.This drop determined curative effect and having no side effect.
Technical scheme of the present invention is:
Treat a drop for otitis media, be prepared from by following bulk drugs, be weight portion: Fructus Trichosanthis 11-15; Herba Andrographis 9-13; Chrysosplenium Hydrocotylifolium Levl. Et Van. 7-16; Semen Benincasae 10-14; Herba Ainsliaeae Latifoliae 8-15; Herba Stephaniae Longae 6-12; Rhizoma Acori Graminei 8-13; Folium Hibisci Mutabilis 10-15; Asterias amurensis Lutken 7-14; Herba Oberoniae Myosuri 9-15; Herb Polygoni Chinensis 8-16; Folium Et Cacumen Murrayae 10-13; Resina Populi Diversifoliae 7-16; Herba Carpesii Divaricati 9-12; Spica Prunellae 11-14; Flos Granati 10-12.
In preferred scheme, Fructus Trichosanthis 12-14; Herba Andrographis 10-12; Chrysosplenium Hydrocotylifolium Levl. Et Van. 10-13; Semen Benincasae 11-13; Herba Ainsliaeae Latifoliae 10-13; Herba Stephaniae Longae 8-10; Rhizoma Acori Graminei 9-12; Folium Hibisci Mutabilis 11-14; Asterias amurensis Lutken 9-12; Herba Oberoniae Myosuri 11-13; Herb Polygoni Chinensis 10-14; Folium Et Cacumen Murrayae 11-12; Resina Populi Diversifoliae 9-14; Herba Carpesii Divaricati 10-11; Spica Prunellae 12-13; Flos Granati 10.5-11.5.
Be more preferably, Fructus Trichosanthis 13; Herba Andrographis 11; Chrysosplenium Hydrocotylifolium Levl. Et Van. 11.5; Semen Benincasae 12; Herba Ainsliaeae Latifoliae 11.5; Herba Stephaniae Longae 9; Rhizoma Acori Graminei 10.5; Folium Hibisci Mutabilis 12.5; Asterias amurensis Lutken 10.5; Herba Oberoniae Myosuri 12; Herb Polygoni Chinensis 12; Folium Et Cacumen Murrayae 11.5; Resina Populi Diversifoliae 11.5; Herba Carpesii Divaricati 10.5; Spica Prunellae 12.5; Flos Granati 11.
Treat a preparation method for the drop of otitis media, step is as follows:
(1) Fructus Trichosanthis is cleaned, and puts in hot pot, and slow fire heats, and fry to heaving, taking-up cools, for subsequent use; Rhizoma Acori Graminei is cleaned, and is placed in rice-washed water, and soak under room temperature 3-5 hour (soaking 4 hours under being preferable over room temperature), taking-up cools, for subsequent use;
(2) Resina Populi Diversifoliae is smashed to pieces, puts in frying pan, and slow fire stir-fries to being outward be spend in sepia in burnt brown, and taking-up cools, for subsequent use; Flos Granati is cleaned, and adds the refined honey diluted, mixes thoroughly, vexed 5-10 minute (preferably vexed 8 minutes), and slow fire adds to be propagandized hotly to tack-free for spending, and taking-up is dry, for subsequent use;
(3) crude drug after step (1) and (2) process is placed in Chinese medicament extracting device with surplus stock medicine, add the pure water (preferably adding the pure water of 8 times amount) of 6-10 times amount, soak under room temperature 4-6 hour (soaking 5 hours under preferred room temperature), then reflux, extract, three times, each each reflux, extract, 30-50 minute (preferred each each reflux, extract, 40 minutes), merges three extracting solution, filters, it is the thick paste of 1.30-1.33 that filtrate is concentrated into 80 DEG C of relative densities, for subsequent use;
(4) in above-mentioned thick paste, add the ethanol (preferably adding the ethanol of 4.5 times amount) of 3-6 times amount, stir once along same direction, leave standstill 10-18 hour (preferably leaving standstill 14 hours), get supernatant, reclaim ethanol, concentrating under reduced pressure, dry, sieve, obtain fine powder, for subsequent use;
(5) in above-mentioned fine powder, add the purified water of 3-6 times amount and the mixed liquor (preferably adding the purified water of 4.5 times amount and the mixed liquor of propylene glycol) of propylene glycol, wherein the volume ratio of purified water and propylene glycol is 3:1, then the cosolvent that mass fraction is 0.5% is added, stirring makes it abundant dissolving, finally add mass fraction be 2.3% stabilizing agent and mass fraction be the correctives of 3.5%, mix homogeneously, through ultrafiltration membrance filter, subpackage, to obtain final product.
Above-mentioned a kind of preparation method for the treatment of the drop of otitis media, preferred scheme is, in step (4), the mass concentration of added ethanol is the mass concentration of the preferred added ethanol of 45%-75%(is 55%-65%, and the mass concentration of the added ethanol be more preferably is 60%).
Above-mentioned a kind of preparation method for the treatment of the drop of otitis media, preferred scheme is, the middle 100-160 mesh sieve excessively of step (4) (preferred 120-140 mesh sieve excessively, mistake 130 mesh sieve be more preferably).
Above-mentioned a kind of preparation method for the treatment of the drop of otitis media, preferred scheme is, cosolvent described in step (5) is one in tween 80, Borax and hexadecanol (preferred described cosolvent is the one in tween 80 and Borax, and the described cosolvent be more preferably is tween 80).
Above-mentioned a kind of preparation method for the treatment of the drop of otitis media, preferred scheme is, stabilizing agent described in step (5) is one in glycerol, Polyethylene Glycol and sodium pyrosulfite (preferred described stabilizing agent is the one in glycerol and Polyethylene Glycol, and the described stabilizing agent be more preferably is glycerol).
Above-mentioned a kind of preparation method for the treatment of the drop of otitis media, preferred scheme is, correctives described in step (5) is one in sorbitol, Herba Menthae Haplocalycis volatile oil and Folium Stevlae Rebaudianae (preferred described correctives is the one in sorbitol and Herba Menthae Haplocalycis volatile oil, and the described correctives be more preferably is sorbitol).
Above-mentioned a kind of preparation method for the treatment of the drop of otitis media, preferred scheme is, in step (5), the aperture of ultrafilter membrane is 0.008-0.02 μm (aperture of preferred ultrafilter membrane is 0.012-0.16 μm, and the aperture of the ultrafilter membrane be more preferably is 0.014 μm).
Chinese medicine preparation scientific formula provided by the invention, the preparation method of various dosage form is simple, products obtained therefrom taking convenience, is easy to carry.In addition, excellent results of the present invention also shows:
1,medicine of the present invention supplements and complements each other, and penetrates with absorbability strong, and through affected part, curative effect is fast and lastingly, external is convenient, safe and reliable, has no side effect.
2,medicine of the present invention, except having the effects such as antibacterial, antiviral, detumescence and apocenosis, particularly has the effect of thoroughly curing to the hyperemia in various degree of ear's tympanum, swelling etc.;
3,the present invention develops in conjunction with latest modern technological scientific achievement on the basis of traditional tcm syndrome differentiation and treatment, and all medicines share, and has evident in efficacy, safe ready, cheap feature.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited thereto.
The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:
Fructus Trichosanthis: base is former: be the fruit of cucurbitaceous plant Fructus Trichosanthis.Chemical analysis: fruit is containing triterpenoid saponin, organic acid, resin, saccharide and pigment.The fatty oil of seed.Pharmacological action: antibacterial, antitumaous effect.Nature and flavor: sweetness and bitterness, cold.Gui Jing: enter lung, stomach, large intestine channel.Function cures mainly: lung moistening, reduces phlegm, eliminating stagnation, laxation.Control phlegm-heat cough, the thoracic obstruction, blocked-up chest, consumptive lung disease hemoptysis, quenches one's thirst, jaundice, constipation, carbuncle from the beginning of.
Herba Andrographis: base is former: be herb or the leaf of acanthaceous plant Herba Andrographis.Chemical analysis: leaf is containing diterpenic lactone: dexyandrographolide and desoxyandrographolide more than 0.1%, andrographolide and andrographolide more than 1.5%, Neoandrographolide and neoandrographolide more than 0.2%; And homoandrographolide, panicolide.Also containing andnrographan, andrographon, phosterin, cupreol-D-Glucose glycoside etc.Herb is still oxidized andrographolide, 14-deoxidation-11,12-bis-dehydrogenation andrographolide containing 14-deoxidation-11-, according to another preliminary analysis, also containing aldehydes matters such as sterol Saponin, saccharide and condensed tannins.Pharmacological action: 1. antibacterial action; 2. antivirus action; Nature and flavor: " Quanzhou book on Chinese herbal medicine ": " bitter in the mouth, cold in nature, nontoxic." return through " Quanzhou book on Chinese herbal medicine ": " enter the heart, lung two warp." function cures mainly: heat-clearing and toxic substances removing, removing heat from blood is subsided a swelling.Control acute bacillary dysentery, gastroenteritis, flu, epidemic encephalitis, tracheitis, pneumonia, pertussis, pulmonary tuberculosis, lung abscess, cholecystitis, hypertension, epistaxis, oropharynx swells and ache, furuncle carbuncle, burn due to hot liquid or fire, venom.
Chrysosplenium Hydrocotylifolium Levl. Et Van.: base is former: be the herb of saxifragaceae plant Chrysosplenium Hydrocotylifolium Levl. Et Van..Nature and flavor: micro-hardship, pungent; Cold; Mild toxicity.Gui Jing: the heart; Lung meridian.Function cures mainly: heat-clearing and toxic substances removing; Promoting blood circulation and hemostasis.Djumah rash, high heat, cough, otitis media, bronchitis, spitting of blood, spits blood, skin allergy, menoxenia, parotitis, mastitis, innominate toxic swelling, venom, skin ulcer, eczema, burn and scald.
Semen Benincasae: base is former: be the seed of cucurbitaceous plant Fructus Benincasae.Chemical analysis: seed is containing Saponin 0.68%, fat, carbamide, citrulline etc.Nature and flavor: sweet are cool.Gui Jing: " must book on Chinese herbal medicine be joined ": " enter meridian of Foot-JUE YIN." function cures mainly: lung moistening, reduce phlegm, eliminating carbuncle, diuretic.Control phlegm-heat cough, lung abscess, acute appendicitis, gonorrhea, edema, beriberi, hemorrhoid, nasal surface wine Zha.
Herba Ainsliaeae Latifoliae: base is former: be the herb of feverfew Herba Ainsliaeae Latifoliae.Nature and flavor: acrid in the mouth; Micro-hardship; Warm in nature.Function cures mainly: expelling wind and cold; Promoting blood circulation and detumescence.Main anemofrigid cold; Headache; Lumbago; Intestinal fire; Dysentery; Traumatic injury congestive edema; Traumatic hemorrhage; Otitis media; Mastitis.
Herba Stephaniae Longae: base is former: be the herb of menispermaceous plants Herba Stephaniae Longae or rhizome and root.Chemical analysis: Herba Stephaniae Longae root is containing Radix Stephaniae Japonicae ripple woods alkali, and longanine, longanone, cycleanine, homoaromoline alkali, Radix Stephaniae Japonicae is worshipped stars alkali, and former Radix Stephaniae Japonicae is worshipped stars alkali.Nature and flavor: bitter; Cold.Gui Jing: liver; Gallbladder; Large intestine channel.Function cures mainly: heat-clearing and toxic substances removing; Inducing diuresis and reducing edema; Dispelling, collateral-activating.Main dysentery; Urine leaching is puckery; Edema; Jaundice; Rheumatic arthralgia; Sore throat; Ting ear; Sore and toxic; Venom.
Rhizoma Acori Graminei: another name Rhizoma Anemones Altaicae, water Rhizoma Acori Graminei, powder Chang, mountain Rhizoma Acori Graminei, small stream Chang, stone Scolopendra, wild leek.Base is former: be the rhizome of ranunculaceae plant anemone altaica.Nature and flavor: pungent, flat or tepor.Gui Jing: GUIXIN, liver, spleen channel.Fresh goods strong flavor, pungent loose power more wins than dry product, therefore the good merchantable brand for declaring gas sensible.This product had both been longer than removing dampness by means of aromatics, activating spleen and strengthening stomach, was used for the treatment of cloudy stagnant middle Jiao of turbid damp, vexed swollen, all diseases of anorexia of functional activity of QI being not smooth, breast gastral cavity; And again can fragrant magnificent expectorant turbid, resuscitation inducing and mind tranquilizing, is used for the treatment of the mind that turbid damp hoodwinks clearly caused by key dazed and confused, the disease of white and greasy fur; And arrogate to oneself the unconsciousness controlled expectorant heat and fall caused by stagnant pericardium, the diseases such as tic.
Folium Hibisci Mutabilis: base is former: be the leaf of Malvaceae plant Hibisci Mutabilis.Chemical analysis: containing flavonoid glycoside, phenols, aminoacid, reducing sugar, phlegmatic temperament.Nature and flavor: cool in nature, taste is micro-pungent.Function cures mainly: Qingfei Liangxue, detumescence and apocenosis.For cough due to lung-heat, hypertrophic rhinitis, lymphadenitis, appendicitis, carbuncle furuncle abscess, acute otitis media, burn, scald.
Asterias amurensis Lutken: medical material Ji Yuan: for Astropectinidae animal Craspidaster hesperus (mulleret Troschel). and he plant the entirety of Asterias amurensis Lutken.Chemical analysis: containing Asterias amurensis Lutken Saponin A and B.Pharmacological action: Asterias amurensis Lutken Saponin can make sperm lose vigor, and can induce ovulation and ejaculation effect.Nature and flavor: salty in the mouth; Property is put down.Gui Jing: the heart; Stomach; Large intestine channel.Function cures mainly: detoxicating and resolving stagnation of pathogens; And stomach and alleviating pain.Main thyromegaly; Scrofula; Stomachache pantothenic acid; Diarrhoea otitis media.
Herba Oberoniae Myosuri: base is former: be the herb of orchid rod leaf mandarin duck tail orchid.Nature and flavor: pungent; Micro-hardship; Cool.Gui Jing: kidney; Urinary bladder channel.Function cures mainly: heat-clearing and toxic substances removing; Dissipating blood stasis stops blooding.Main bronchus is scorching; Pneumonia; Hepatitis; Urinary tract infection; Otitis media; Carbuncle sore; Fracture; Traumatic hemorrhage.
Herb Polygoni Chinensis: base is former: be the herb of polygonaceae plant Herb Polygoni Chinensis.Chemical analysis: contain β-paddy in leaf from alcohol, kaempferol, Quercetin, benzoaric acid, gallic acid, 3-O-methyl benzoaric acid, nimbecetin-7-O-glycoside, Kaempferol-O-glucuronide.Pharmacological action: 1. antibacterial action: this product decoct all has stronger antibacterial action to staphylococcus aureus, escherichia coli, anthrax bacillus, group B streptococcus, diphtheria corynebacterium, Bacillus typhi, bacillus pyocyaneus and dysentery bacterium in vitro; 2. Anti-hepatitis B virus effects; 3. the effect of pair smooth muscle and skeletal muscle; 4. hypotensive effect; 5. central inhibitory action.Nature and flavor: pungent; Bitter; Cool in nature; Poisonous.Function cures mainly: clearing away heat-damp and promoting diuresis; Removing pathogenic heat from blood and toxic substance from the body; Suppressing the hyperactive liver improving eyesight; Relaxing muscles and tendons to promote blood circulation.Main dysentery; Have loose bowels; Laryngopharynx swelling and pain; Diphtheria; Cough due to lung-heat; Pertussis; Hepatitis; Leukorrhagia; Cancerous protuberance; Otitis media; Eczema; Vertigo and tinnitus; Corneal nebula; Traumatic injury.
Folium Et Cacumen Murrayae: base is former: be the branch and leaf of rutaceae Folium Et Cacumen Murrayae.Pharmacological action: 1. stem and leaf decoct has local anesthesia effect; 2. from this product ligroin extraction, get a kind of unazotized crystallinity composition (decomposition point 91-92 DEG C), have obvious relexation to Isolated Rat intestinal, can to the smooth muscle spasm caused by antihistamine, barium chloride; 4. congener Murraya koenigii(L)Spreng. is to the pathogenic fungus of people, has special inhibitory action.Nature and flavor: acrid in the mouth; Micro-hardship; Warm in nature; Mild toxicity.Gui Jing: the heart; Liver; Lung meridian.Function cures mainly: promoting flow of QI and blood; Eliminating stasis to stop pain; Removing toxic substances and promoting subsidence of swelling.Main gastralgia; Tumbling and swelling; Carbuncle sore; Snake bite and insect sting.
Resina Populi Diversifoliae: base is former: be the resin of Salicaceous Plants Populus euphratica, retain in soil and form for many years.Nature and flavor: Tang Materia Medica: " salty in the mouth is bitter, Great Cold, nontoxic." return through: enter stomach warp.Function cures mainly: heat clearing away, reduces phlegm, softening the hard mass.Control laryngopharynx swelling and pain, toothache, gingival atrophy, ulcerative gingivitis, the osteomyelitis of the maxillary bone, scrofula.
Herba Carpesii Divaricati: base is former: be the herb of feverfew Herba Carpesii Divaricati.Chemical analysis: dig Wei Su A, B, C containing gold.Nature and flavor: bitter in the mouth; Pungent; Cold in nature.Function cures mainly: heat-clearing and toxic substances removing; Reducing swelling and alleviating pain.Main cold, fever; Wind syndrome of head; The scorching acute conjunctivitis of wind; Laryngopharynx swelling and pain; Zha rib; Toothache; Acute mastitis; Furuncle toxic swelling; Haemorrhoids is hemorrhage; Stomachache is had loose bowels; Acute infantile convulsion.
Flos Granati: base is former: the alabastrum of Punicaceae plant Punica granatum L..Nature and flavor: sour in the mouth; Puckery; Property is put down.Function cures mainly: removing heat from blood; Hemostasis.Main epistaxis; Spit blood; Traumatic hemorrhage; Menoxenia; Redly collapse leucorrhea; Otitis media.
Spica Prunellae: base is former: this product is the dry fruit ear of labiate Spica Prunellae.Chemical analysis: herb is containing triterpenoid saponin, its glycoside unit is oleanolic acid, still containing free oleanolic acid, ursolic acid, globulariacitrin, hyperin, cis-caffeic acid, trans-caffeic acid, vitamin B1, vitamin C, vitamin K, carotene, resin, amaroid, tannin, volatile oil, alkaloid, water soluble salt (about 3.5%, wherein about 63% is potassium chloride) etc.Nature and flavor: pungent, bitter, cold.Gui Jing: return liver, gallbladder meridian.Pharmacological action: 1. hypotensive effect, 2. antibacterial action.Effect: relieve inflammation or internal heat, improving eyesight, eliminating stagnation, detumescence.Cure mainly: for conjunctival congestion and swelling pain, order pearl nyctalgia, has a headache dizzy, scrofula, goiter, and acute mastitis swells and ache; Thyromegaly, tuberculous lymphadenitis, cyclomastopathy, hypertension.
embodiment 1treat a drop for otitis media, be prepared from by following bulk drugs, be weight portion (every part of 10g): Fructus Trichosanthis 11 parts; Herba Andrographis 9 parts; Chrysosplenium Hydrocotylifolium Levl. Et Van. 7 parts; Semen Benincasae 10 parts; Herba Ainsliaeae Latifoliae 8 parts; Herba Stephaniae Longae 6 parts; Rhizoma Acori Graminei 8 parts; Folium Hibisci Mutabilis 10 parts; Asterias amurensis Lutken 7 parts; Herba Oberoniae Myosuri 9 parts; Herb Polygoni Chinensis 8 parts; Folium Et Cacumen Murrayae 10 parts; Resina Populi Diversifoliae 7 parts; Herba Carpesii Divaricati 9 parts; Spica Prunellae 11 parts; Flos Granati 10 parts.
A kind of preparation method for the treatment of the drop of otitis media is:
(1) Fructus Trichosanthis is cleaned, and puts in hot pot, and slow fire heats, and fry to heaving, taking-up cools, for subsequent use; Rhizoma Acori Graminei is cleaned, and is placed in rice-washed water, and soak 3 hours under room temperature, taking-up cools, for subsequent use;
(2) Resina Populi Diversifoliae is smashed to pieces, puts in frying pan, and slow fire stir-fries to being outward be spend in sepia in burnt brown, and taking-up cools, for subsequent use; Flos Granati is cleaned, and adds the refined honey diluted, mixes thoroughly, vexed 5 minutes, and slow fire adds to be propagandized hotly to tack-free for spending, and taking-up is dry, for subsequent use;
(3) crude drug after step (1) and (2) process is placed in Chinese medicament extracting device with surplus stock medicine, add the pure water of 6 times amount, soak 4 hours under room temperature, then reflux, extract, three times, each each reflux, extract, 30 minutes, merges three extracting solution, filters, it is the thick paste of 1.30-1.33 that filtrate is concentrated into 80 DEG C of relative densities, for subsequent use;
(4) in above-mentioned thick paste, the mass concentration adding 3 times amount is the ethanol of 45%, stirs once along same direction, leaves standstill 10 hours, gets supernatant, reclaims ethanol, concentrating under reduced pressure, dry, crosses 100 mesh sieves, obtains fine powder, for subsequent use;
(5) in above-mentioned fine powder, the purified water of 3 times amount and the mixed liquor of propylene glycol is added, wherein the volume ratio of purified water and propylene glycol is 3:1, then the cosolvent (described cosolvent is tween 80) that mass fraction is 0.5% is added, stirring makes it abundant dissolving, finally add mass fraction be 2.3% stabilizing agent (described stabilizing agent is glycerol) and mass fraction be 3.5% correctives (described correctives is sorbitol), mix homogeneously, via hole diameter is 0.008 μm of ultrafiltration membrance filter, subpackage, to obtain final product.
The using method of gained drop of the present invention is: every day 3 times, each 3-5 drips, 10 days courses for the treatment of.(suffer from ear external auditory meatus upward, by auricle tractive rearwardly and upwardly, ear drop slowly flows in ear along external auditory meatus.Drip medicine future trouble ear and should keep 3-5 minute upward, so that medicine plays one's part to the full).
Model case: Song XX, man, 16 years old, patient's readme: the obvious pruritus of external ear on the left of two weeks causes, after digging scratch with hands, have obvious pain, nearby pharmacy is inquired and is bought the medicine treatments such as Cefixime Capsules subsequently, after one week for the treatment of, symptom has no alleviation, recently the pain increased to feel left ear, the difficult peace of sleep, to our hospital upon somebody's introduction.Check: patient's take temperature 38.8 DEG C, otoscopy is without bleeding property of auditory meatus or bean curd slag specimen secretions, and tympanum is congested, and swelling, is diagnosed as otitis media.
Use a kind of drop for the treatment of otitis media of the present embodiment gained, using method: every day 3 times, each 3-5 drips, 10 days courses for the treatment of.(suffer from ear external auditory meatus upward, by auricle tractive rearwardly and upwardly, ear drop slowly flows in ear along external auditory meatus.Drip medicine future trouble ear and should keep 3-5 minute upward, so that medicine plays one's part to the full).
After using two courses for the treatment of, patient's otalgia is obviously alleviated, sleep can, other symptom takes a turn for the better, and continues two courses for the treatment of of use, and check that patient's tympanum is congested, swelling phenomenon, patient's self-induction is fully recovered, and pay a return visit after half a year, patient is without recurrence.
embodiment 2treat a drop for otitis media, be prepared from by following bulk drugs, be weight portion (every part of 10g): Fructus Trichosanthis 15 parts; Herba Andrographis 13 parts; Chrysosplenium Hydrocotylifolium Levl. Et Van. 16 parts; Semen Benincasae 14 parts; Herba Ainsliaeae Latifoliae 15 parts; Herba Stephaniae Longae 12 parts; Rhizoma Acori Graminei 13 parts; Folium Hibisci Mutabilis 15 parts; Asterias amurensis Lutken 14 parts; Herba Oberoniae Myosuri 15 parts; Herb Polygoni Chinensis 16 parts; Folium Et Cacumen Murrayae 13 parts; Resina Populi Diversifoliae 16 parts; Herba Carpesii Divaricati 12 parts; Spica Prunellae 14 parts; Flos Granati 12 parts.
A kind of preparation method for the treatment of the drop of otitis media is:
(1) Fructus Trichosanthis is cleaned, and puts in hot pot, and slow fire heats, and fry to heaving, taking-up cools, for subsequent use; Rhizoma Acori Graminei is cleaned, and is placed in rice-washed water, and soak 5 hours under room temperature, taking-up cools, for subsequent use;
(2) Resina Populi Diversifoliae is smashed to pieces, puts in frying pan, and slow fire stir-fries to being outward be spend in sepia in burnt brown, and taking-up cools, for subsequent use; Flos Granati is cleaned, and adds the refined honey diluted, mixes thoroughly, vexed 10 minutes, and slow fire adds to be propagandized hotly to tack-free for spending, and taking-up is dry, for subsequent use;
(3) crude drug after step (1) and (2) process is placed in Chinese medicament extracting device with surplus stock medicine, add the pure water of 10 times amount, soak 6 hours under room temperature, then reflux, extract, three times, each each reflux, extract, 50 minutes, merges three extracting solution, filters, it is the thick paste of 1.30-1.33 that filtrate is concentrated into 80 DEG C of relative densities, for subsequent use;
(4) in above-mentioned thick paste, the mass concentration adding 6 times amount is the ethanol of 75%, stirs once along same direction, leaves standstill 18 hours, gets supernatant, reclaims ethanol, concentrating under reduced pressure, dry, crosses 160 mesh sieves, obtains fine powder, for subsequent use;
(5) in above-mentioned fine powder, the purified water of 6 times amount and the mixed liquor of propylene glycol is added, wherein the volume ratio of purified water and propylene glycol is 3:1, then the cosolvent (described cosolvent is tween 80) that mass fraction is 0.5% is added, stirring makes it abundant dissolving, finally add mass fraction be 2.3% stabilizing agent (described stabilizing agent is glycerol) and mass fraction be 3.5% correctives (described correctives is sorbitol), mix homogeneously, via hole diameter is 0.02 μm of ultrafiltration membrance filter, subpackage, to obtain final product.
The using method of gained drop of the present invention is: every day 3 times, each 3-5 drips, 10 days courses for the treatment of.(suffer from ear external auditory meatus upward, by auricle tractive rearwardly and upwardly, ear drop slowly flows in ear along external auditory meatus.Drip medicine future trouble ear and should keep 3-5 minute upward, so that medicine plays one's part to the full).
embodiment 3treat a drop for otitis media, be prepared from by following bulk drugs, be weight portion (every part of 10g): Fructus Trichosanthis 12 parts; Herba Andrographis 10 parts; Chrysosplenium Hydrocotylifolium Levl. Et Van. 10 parts; Semen Benincasae 11 parts; Herba Ainsliaeae Latifoliae 10 parts; Herba Stephaniae Longae 8 parts; Rhizoma Acori Graminei 9 parts; Folium Hibisci Mutabilis 11 parts; Asterias amurensis Lutken 9 parts; Herba Oberoniae Myosuri 11 parts; Herb Polygoni Chinensis 10 parts; Folium Et Cacumen Murrayae 11 parts; Resina Populi Diversifoliae 9 parts; Herba Carpesii Divaricati 10 parts; Spica Prunellae 12 parts; Flos Granati 10.5 parts.
A kind of preparation method for the treatment of the drop of otitis media is:
(1) Fructus Trichosanthis is cleaned, and puts in hot pot, and slow fire heats, and fry to heaving, taking-up cools, for subsequent use; Rhizoma Acori Graminei is cleaned, and is placed in rice-washed water, and soak 3.5 hours under room temperature, taking-up cools, for subsequent use;
(2) Resina Populi Diversifoliae is smashed to pieces, puts in frying pan, and slow fire stir-fries to being outward be spend in sepia in burnt brown, and taking-up cools, for subsequent use; Flos Granati is cleaned, and adds the refined honey diluted, mixes thoroughly, vexed 6 minutes, and slow fire adds to be propagandized hotly to tack-free for spending, and taking-up is dry, for subsequent use;
(3) crude drug after step (1) and (2) process is placed in Chinese medicament extracting device with surplus stock medicine, add the pure water of 7 times amount, soak 4.5 hours under room temperature, then reflux, extract, three times, each each reflux, extract, 35 minutes, merges three extracting solution, filters, it is the thick paste of 1.30-1.33 that filtrate is concentrated into 80 DEG C of relative densities, for subsequent use;
(4) in above-mentioned thick paste, the mass concentration adding 4 times amount is the ethanol of 55%, stirs once along same direction, leaves standstill 12 hours, gets supernatant, reclaims ethanol, concentrating under reduced pressure, dry, crosses 120 mesh sieves, obtains fine powder, for subsequent use;
(5) in above-mentioned fine powder, the purified water of 4 times amount and the mixed liquor of propylene glycol is added, wherein the volume ratio of purified water and propylene glycol is 3:1, then the cosolvent (described cosolvent is tween 80) that mass fraction is 0.5% is added, stirring makes it abundant dissolving, finally add mass fraction be 2.3% stabilizing agent (described stabilizing agent is glycerol) and mass fraction be 3.5% correctives (described correctives is sorbitol), mix homogeneously, via hole diameter is 0.12 μm of ultrafiltration membrance filter, subpackage, to obtain final product.
The using method of gained drop of the present invention is: every day 3 times, each 3-5 drips, 10 days courses for the treatment of.(suffer from ear external auditory meatus upward, by auricle tractive rearwardly and upwardly, ear drop slowly flows in ear along external auditory meatus.Drip medicine future trouble ear and should keep 3-5 minute upward, so that medicine plays one's part to the full).
Model case: Qin XX, man, 27 years old, patient was to our hospital on August 9th, 2011.Patient's readme: to suppurate symptom because auris dextra appears in respiratory tract infection the year before, pus is thinner, odorless, once treated at certain examination in hospital, gave oral anti-infective drugs thing and the treatment of external drop, after treatment, auris dextra is suppurated stopping, and nearly two weeks, auris dextra auditory dysesthesia appearred in patient, there is symptom of suppurating again after ear's water inlet, introduce my institute by friend and check treatment.Check: patient's membrana tympana auris dextrae tense part large perforation, visible granulation in tympanum, auris dextra pus is thin, free from extraneous odour, patient mental and sleep still can, temporal bone CT shows left side tympanum, visible soft tissue shadow in tympanic antrum, the focal destruction of periphery sclerotin, auditory ossicles partial destruction, is diagnosed as chronic suppurative otitis media.
Use a kind of drop for the treatment of otitis media of the present embodiment gained, using method: every day 3 times, each 3-5 drips, 10 days courses for the treatment of.(suffer from ear external auditory meatus upward, by auricle tractive rearwardly and upwardly, ear drop slowly flows in ear along external auditory meatus.Drip medicine future trouble ear and should keep 3-5 minute upward, so that medicine plays one's part to the full).After using two courses for the treatment of, patient's auris dextra pus obviously reduces, and audition obviously promotes, other symptom and sign all take a favorable turn, after using four courses for the treatment of, patient's auris dextra is dry, without pus, partial symptoms disappears or obviously alleviates, after using a course for the treatment of again, patient fully recovers, and does not occur any discomfort when patient uses, pay a return visit after half a year, without recurrence.
embodiment 4treat a drop for otitis media, be prepared from by following bulk drugs, be weight portion (every part of 10g): Fructus Trichosanthis 14 parts; Herba Andrographis 12 parts; Chrysosplenium Hydrocotylifolium Levl. Et Van. 13 parts; Semen Benincasae 13 parts; Herba Ainsliaeae Latifoliae 13 parts; Herba Stephaniae Longae 10 parts; Rhizoma Acori Graminei 12 parts; Folium Hibisci Mutabilis 14 parts; Asterias amurensis Lutken 12 parts; Herba Oberoniae Myosuri 13 parts; Herb Polygoni Chinensis 14 parts; Folium Et Cacumen Murrayae 12 parts; Resina Populi Diversifoliae 14 parts; Herba Carpesii Divaricati 11 parts; Spica Prunellae 13 parts; Flos Granati 11.5 parts.
A kind of preparation method for the treatment of the drop of otitis media is:
(1) Fructus Trichosanthis is cleaned, and puts in hot pot, and slow fire heats, and fry to heaving, taking-up cools, for subsequent use; Rhizoma Acori Graminei is cleaned, and is placed in rice-washed water, and soak 4.5 hours under room temperature, taking-up cools, for subsequent use;
(2) Resina Populi Diversifoliae is smashed to pieces, puts in frying pan, and slow fire stir-fries to being outward be spend in sepia in burnt brown, and taking-up cools, for subsequent use; Flos Granati is cleaned, and adds the refined honey diluted, mixes thoroughly, vexed 9 minutes, and slow fire adds to be propagandized hotly to tack-free for spending, and taking-up is dry, for subsequent use;
(3) crude drug after step (1) and (2) process is placed in Chinese medicament extracting device with surplus stock medicine, add the pure water of 9 times amount, soak 5.5 hours under room temperature, then reflux, extract, three times, each each reflux, extract, 45 minutes, merges three extracting solution, filters, it is the thick paste of 1.30-1.33 that filtrate is concentrated into 80 DEG C of relative densities, for subsequent use;
(4) in above-mentioned thick paste, the mass concentration adding 5 times amount is the ethanol of 65%, stirs once along same direction, leaves standstill 16 hours, gets supernatant, reclaims ethanol, concentrating under reduced pressure, dry, crosses 140 mesh sieves, obtains fine powder, for subsequent use;
(5) in above-mentioned fine powder, the purified water of 5.5 times amount and the mixed liquor of propylene glycol is added, wherein the volume ratio of purified water and propylene glycol is 3:1, then the cosolvent (described cosolvent is tween 80) that mass fraction is 0.5% is added, stirring makes it abundant dissolving, finally add mass fraction be 2.3% stabilizing agent (described stabilizing agent is glycerol) and mass fraction be 3.5% correctives (described correctives is sorbitol), mix homogeneously, via hole diameter is 0.16 μm of ultrafiltration membrance filter, subpackage, to obtain final product.
The using method of gained drop of the present invention is: every day 3 times, each 3-5 drips, 10 days courses for the treatment of.(suffer from ear external auditory meatus upward, by auricle tractive rearwardly and upwardly, ear drop slowly flows in ear along external auditory meatus.Drip medicine future trouble ear and should keep 3-5 minute upward, so that medicine plays one's part to the full).
embodiment 5treat a drop for otitis media, be prepared from by following bulk drugs, be weight portion (every part of 10g): Fructus Trichosanthis 13 parts; Herba Andrographis 11 parts; Chrysosplenium Hydrocotylifolium Levl. Et Van. 11.5 parts; Semen Benincasae 12 parts; Herba Ainsliaeae Latifoliae 11.5 parts; Herba Stephaniae Longae 9 parts; Rhizoma Acori Graminei 10.5 parts; Folium Hibisci Mutabilis 12.5 parts; Asterias amurensis Lutken 10.5 parts; Herba Oberoniae Myosuri 12 parts; Herb Polygoni Chinensis 12 parts; Folium Et Cacumen Murrayae 11.5 parts; Resina Populi Diversifoliae 11.5 parts; Herba Carpesii Divaricati 10.5 parts; Spica Prunellae 12.5 parts; Flos Granati 11 parts.
A kind of preparation method for the treatment of the drop of otitis media is:
(1) Fructus Trichosanthis is cleaned, and puts in hot pot, and slow fire heats, and fry to heaving, taking-up cools, for subsequent use; Rhizoma Acori Graminei is cleaned, and is placed in rice-washed water, and soak 4 hours under room temperature, taking-up cools, for subsequent use;
(2) Resina Populi Diversifoliae is smashed to pieces, puts in frying pan, and slow fire stir-fries to being outward be spend in sepia in burnt brown, and taking-up cools, for subsequent use; Flos Granati is cleaned, and adds the refined honey diluted, mixes thoroughly, vexed 8 minutes, and slow fire adds to be propagandized hotly to tack-free for spending, and taking-up is dry, for subsequent use;
(3) crude drug after step (1) and (2) process is placed in Chinese medicament extracting device with surplus stock medicine, add the pure water of 8 times amount, soak 5 hours under room temperature, then reflux, extract, three times, each each reflux, extract, 40 minutes, merges three extracting solution, filters, it is the thick paste of 1.30-1.33 that filtrate is concentrated into 80 DEG C of relative densities, for subsequent use;
(4) in above-mentioned thick paste, the mass concentration adding 4.5 times amount is the ethanol of 60%, stirs once along same direction, leaves standstill 14 hours, gets supernatant, reclaims ethanol, concentrating under reduced pressure, dry, crosses 130 mesh sieves, obtains fine powder, for subsequent use;
(5) in above-mentioned fine powder, the purified water of 4.5 times amount and the mixed liquor of propylene glycol is added, wherein the volume ratio of purified water and propylene glycol is 3:1, then the cosolvent (described cosolvent is tween 80) that mass fraction is 0.5% is added, stirring makes it abundant dissolving, finally add mass fraction be 2.3% stabilizing agent (described stabilizing agent is glycerol) and mass fraction be 3.5% correctives (described correctives is sorbitol), mix homogeneously, via hole diameter is the ultrafiltration membrance filter of 0.014 μm, subpackage, to obtain final product.
The using method of gained drop of the present invention is: every day 3 times, each 3-5 drips, 10 days courses for the treatment of.(suffer from ear external auditory meatus upward, by auricle tractive rearwardly and upwardly, ear drop slowly flows in ear along external auditory meatus.Drip medicine future trouble ear and should keep 3-5 minute upward, so that medicine plays one's part to the full).
test example 1the clinical practice of the Chinese medicine preparation (embodiment 5) of gained treatment pharyngitis of the present invention: in August ,-2014 in March, 2010, screen 300 routine otitis media patients in 5 hospital's department of otorhinolaryngologys.In all patients male 168 example, women 132 example, the age 12-31 year, wherein acute suppurative otitis media patient totally 160 example, chronic suppurative otitis media patient totally 83 example, non-suppurative otitis media patient totally 57 example.All patients are divided into two groups at random, experimental group and matched group.Two groups of patients in sex, age, the state of an illness etc. difference there are no significant (P), there is comparability.Therapeutic Method: experimental group uses products obtained therefrom of the present invention, using method: every day 3 times, each 3-5 drips, 10 days courses for the treatment of.(suffer from ear external auditory meatus upward, by auricle tractive rearwardly and upwardly, ear drop slowly flows in ear along external auditory meatus.Drip medicine future trouble ear and should keep 3-5 minute upward, so that medicine plays one's part to the full).Matched group uses other drug (as ofloxacin ear drops, Tarivid Otic Solution, the conventional medicines such as Powder medicine for otitis media).Observe four courses for the treatment of of treatment altogether.Efficacy assessment standard: clinical cure: clinical symptoms and sign all disappear, the phenomenons such as the tympanum hyperemia of otoscopy known ear, swelling disappear, and test room and check normal, have no recurrence in half a year; Effective: clinical symptoms and sign disappear substantially, check that known ear tympanum is congested, swelling phenomenon is obviously alleviated, lab testing improves; Invalid: clinical symptoms and sign are without improvement or increase the weight of.Total effective rate=(clinical cure number of cases+effectively number of cases) ∕ total inspection case load × 100%.Therapeutic outcome is as shown in table 1:
Table 1: the therapeutic outcome of experimental group and matched group patient
Therapeutic effect: experimental group clinical cure 145 example (72.5%), effective 51 examples (25.5%), invalid 4 examples (2%), total effective rate 98%.Successful is better than matched group.
By Fructus Trichosanthis, Herba Andrographis, Chrysosplenium Hydrocotylifolium Levl. Et Van., Semen Benincasae, Herba Ainsliaeae Latifoliae, Herba Stephaniae Longae, Rhizoma Acori Graminei, Folium Hibisci Mutabilis, Asterias amurensis Lutken, Herba Oberoniae Myosuri, Herb Polygoni Chinensis, Folium Et Cacumen Murrayae, Resina Populi Diversifoliae, Herba Carpesii Divaricati, Spica Prunellae and Flos Granati 16, totally 16 taste primary raw material medicines are formulated in the present invention.Fang Zhong, Herba Andrographis heat-clearing and toxic substances removing, removing heat from blood is subsided a swelling; Semen Benincasae eliminating carbuncle, diuretic; Herba Ainsliaeae Latifoliae expelling wind and cold; Promoting blood circulation and detumescence; Herba Stephaniae Longae is inducing diuresis and reducing edema; Dispelling, collateral-activating; It is dazed and confused etc. that Rhizoma Acori Graminei treatment turbid damp hoodwinks mind clearly caused by key; Folium Hibisci Mutabilis Qingfei Liangxue, detumescence and apocenosis; Asterias amurensis Lutken detoxicating and resolving stagnation of pathogens; And stomach and alleviating pain; Herb Polygoni Chinensis all has stronger antibacterial action to staphylococcus aureus, escherichia coli, anthrax bacillus, group B streptococcus, diphtheria corynebacterium, Bacillus typhi, bacillus pyocyaneus and dysentery bacterium; Folium Et Cacumen Murrayae promoting flow of QI and blood; Eliminating stasis to stop pain; Removing toxic substances and promoting subsidence of swelling; Spica Prunellae eliminating stagnation, detumescence.The ingenious prescription of each Chinese herbal medicine, scientific compatibility, medicine is coordinated mutually, plays the specially good effect of heat-clearing and toxic substances removing, detumescence and apocenosis altogether.Treat four courses for the treatment of in experimental group, effective percentage can reach 98%, and matched group is only 76%.
It should be pointed out that detailed description of the invention is the more representational example of the present invention, obvious technical scheme of the present invention is not limited to above-described embodiment, can also have a lot of distortion.Those of ordinary skill in the art, with the present invention clear and definite disclosed or according to undoubted the obtaining of the written description of file, the claimed scope of this patent all should be thought.
Claims (10)
1. treat a drop for otitis media, it is characterized in that, be prepared from by following bulk drugs, be weight portion: Fructus Trichosanthis 11-15; Herba Andrographis 9-13; Chrysosplenium Hydrocotylifolium Levl. Et Van. 7-16; Semen Benincasae 10-14; Herba Ainsliaeae Latifoliae 8-15; Herba Stephaniae Longae 6-12; Rhizoma Acori Graminei 8-13; Folium Hibisci Mutabilis 10-15; Asterias amurensis Lutken 7-14; Herba Oberoniae Myosuri 9-15; Herb Polygoni Chinensis 8-16; Folium Et Cacumen Murrayae 10-13; Resina Populi Diversifoliae 7-16; Herba Carpesii Divaricati 9-12; Spica Prunellae 11-14; Flos Granati 10-12.
2. a kind of drop for the treatment of otitis media as claimed in claim 1, is characterized in that, be prepared from by following bulk drugs, be weight portion: Fructus Trichosanthis 12-14; Herba Andrographis 10-12; Chrysosplenium Hydrocotylifolium Levl. Et Van. 10-13; Semen Benincasae 11-13; Herba Ainsliaeae Latifoliae 10-13; Herba Stephaniae Longae 8-10; Rhizoma Acori Graminei 9-12; Folium Hibisci Mutabilis 11-14; Asterias amurensis Lutken 9-12; Herba Oberoniae Myosuri 11-13; Herb Polygoni Chinensis 10-14; Folium Et Cacumen Murrayae 11-12; Resina Populi Diversifoliae 9-14; Herba Carpesii Divaricati 10-11; Spica Prunellae 12-13; Flos Granati 10.5-11.5.
3. a kind of drop for the treatment of otitis media as claimed in claim 1, is characterized in that, be prepared from by following bulk drugs, be weight portion: Fructus Trichosanthis 13; Herba Andrographis 11; Chrysosplenium Hydrocotylifolium Levl. Et Van. 11.5; Semen Benincasae 12; Herba Ainsliaeae Latifoliae 11.5; Herba Stephaniae Longae 9; Rhizoma Acori Graminei 10.5; Folium Hibisci Mutabilis 12.5; Asterias amurensis Lutken 10.5; Herba Oberoniae Myosuri 12; Herb Polygoni Chinensis 12; Folium Et Cacumen Murrayae 11.5; Resina Populi Diversifoliae 11.5; Herba Carpesii Divaricati 10.5; Spica Prunellae 12.5; Flos Granati 11.
4. a kind of preparation method for the treatment of the drop of otitis media as described in claim 1-3, it is characterized in that, step is as follows:
(1) Fructus Trichosanthis is cleaned, and puts in hot pot, and slow fire heats, and fry to heaving, taking-up cools, for subsequent use; Rhizoma Acori Graminei is cleaned, and is placed in rice-washed water, and soak under room temperature 3-5 hour (soaking 4 hours under being preferable over room temperature), taking-up cools, for subsequent use;
(2) Resina Populi Diversifoliae is smashed to pieces, puts in frying pan, and slow fire stir-fries to being outward be spend in sepia in burnt brown, and taking-up cools, for subsequent use; Flos Granati is cleaned, and adds the refined honey diluted, mixes thoroughly, vexed 5-10 minute (preferably vexed 8 minutes), and slow fire adds to be propagandized hotly to tack-free for spending, and taking-up is dry, for subsequent use;
(3) crude drug after step (1) and (2) process is placed in Chinese medicament extracting device with surplus stock medicine, add the pure water (preferably adding the pure water of 8 times amount) of 6-10 times amount, soak under room temperature 4-6 hour (soaking 5 hours under preferred room temperature), then reflux, extract, three times, each each reflux, extract, 30-50 minute (preferred each each reflux, extract, 40 minutes), merges three extracting solution, filters, it is the thick paste of 1.30-1.33 that filtrate is concentrated into 80 DEG C of relative densities, for subsequent use;
(4) in above-mentioned thick paste, add the ethanol (preferably adding the ethanol of 4.5 times amount) of 3-6 times amount, stir once along same direction, leave standstill 10-18 hour (preferably leaving standstill 14 hours), get supernatant, reclaim ethanol, concentrating under reduced pressure, dry, sieve, obtain fine powder, for subsequent use;
(5) in above-mentioned fine powder, add the purified water of 3-6 times amount and the mixed liquor (preferably adding the purified water of 4.5 times amount and the mixed liquor of propylene glycol) of propylene glycol, wherein the volume ratio of purified water and propylene glycol is 3:1, then the cosolvent that mass fraction is 0.5% is added, stirring makes it abundant dissolving, finally add mass fraction be 2.3% stabilizing agent and mass fraction be the correctives of 3.5%, mix homogeneously, through ultrafiltration membrance filter, subpackage, to obtain final product.
5. a kind of preparation method for the treatment of the drop of otitis media according to claim 4, it is characterized in that, in step (4), the mass concentration of added ethanol is the mass concentration of the preferred added ethanol of 45%-75%(is 55%-65%, and the mass concentration of the added ethanol be more preferably is 60%).
6. a kind of preparation method for the treatment of the drop of otitis media according to claim 4, is characterized in that, the middle 100-160 mesh sieve excessively of step (4) (preferred 120-140 mesh sieve excessively, mistake 130 mesh sieve be more preferably).
7. a kind of preparation method for the treatment of the drop of otitis media according to claim 4, it is characterized in that, cosolvent described in step (5) is one in tween 80, Borax and hexadecanol (preferred described cosolvent is the one in tween 80 and Borax, and the described cosolvent be more preferably is tween 80).
8. a kind of preparation method for the treatment of the drop of otitis media according to claim 4, it is characterized in that, stabilizing agent described in step (5) is one in glycerol, Polyethylene Glycol and sodium pyrosulfite (preferred described stabilizing agent is the one in glycerol and Polyethylene Glycol, and the described stabilizing agent be more preferably is glycerol).
9. a kind of preparation method for the treatment of the drop of otitis media according to claim 4, it is characterized in that, correctives described in step (5) is one in sorbitol, Herba Menthae Haplocalycis volatile oil and Folium Stevlae Rebaudianae (preferred described correctives is the one in sorbitol and Herba Menthae Haplocalycis volatile oil, and the described correctives be more preferably is sorbitol).
10. a kind of preparation method for the treatment of the drop of otitis media according to claim 4, it is characterized in that, in step (5), the aperture of ultrafilter membrane is 0.008-0.02 μm (aperture of preferred ultrafilter membrane is 0.012-0.16 μm, and the aperture of the ultrafilter membrane be more preferably is 0.014 μm).
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105250571A (en) * | 2015-10-10 | 2016-01-20 | 济南高天机械设备有限公司 | Spray preparation for treating liver and gall fire exuberance type acute suppurative otitis media |
| CN106309770A (en) * | 2016-08-15 | 2017-01-11 | 郭修军 | Traditional Chinese medicine preparing for treating otitis media |
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| CN103432243A (en) * | 2013-09-03 | 2013-12-11 | 陈爱美 | Traditional Chinese medicinal preparation for treating infantile exudative otitis media and preparation method thereof |
| CN103495046A (en) * | 2013-08-26 | 2014-01-08 | 许其树 | Traditional Chinese medicine composition for treating tympanitis |
| CN104257945A (en) * | 2014-09-01 | 2015-01-07 | 张晓艳 | Externally applied liniment for treating otitis media |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103495046A (en) * | 2013-08-26 | 2014-01-08 | 许其树 | Traditional Chinese medicine composition for treating tympanitis |
| CN103432243A (en) * | 2013-09-03 | 2013-12-11 | 陈爱美 | Traditional Chinese medicinal preparation for treating infantile exudative otitis media and preparation method thereof |
| CN104257945A (en) * | 2014-09-01 | 2015-01-07 | 张晓艳 | Externally applied liniment for treating otitis media |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105250571A (en) * | 2015-10-10 | 2016-01-20 | 济南高天机械设备有限公司 | Spray preparation for treating liver and gall fire exuberance type acute suppurative otitis media |
| CN106309770A (en) * | 2016-08-15 | 2017-01-11 | 郭修军 | Traditional Chinese medicine preparing for treating otitis media |
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