CN106309770A

CN106309770A - Traditional Chinese medicine preparing for treating otitis media

Info

Publication number: CN106309770A
Application number: CN201610717057.2A
Authority: CN
Inventors: 郭修军; 范学丽
Original assignee: Individual
Current assignee: Individual
Priority date: 2016-08-15
Filing date: 2016-08-15
Publication date: 2017-01-11

Abstract

The invention discloses a traditional Chinese medicine preparing for treating otitis media, which is incorporated into the technical field of traditional Chinese medicine. In the years of clinical treatment practice, according to the etiology of otitis media and traditional Chinese medicine theory of dialectical treatment, inventor chooses Chinese medicine wall pellitory root, stellaria media, blue flower common knotweed, schisandraceae kadsura oblongifolia and gluey bark litse to prepare the Chinese medicine decoction. The clinical trial shows that the total effective rate is 96.7 0%, which are significantly better than a single drug group of the control group. It has better curative effect, and the compatibility of the herbs shows well synergistic effect.

Description

A kind of Chinese medicine preparation treating otitis media

Technical field

The present invention relates to technical field of Chinese medicines, particularly relate to a kind of Chinese medicine preparation treating otitis media.

Background technology

Otitis media is the inflammatory disease involving all or part of structure of middle ear (including tubotympanum tympanic antrum and mastoid air cell) Becoming, the overwhelming majority is non-specific arrangement inflammation, is especially apt to occur in child.Apyetous and suppurative two big classes can be divided into.Its Show as that in ear pain, heating, aversion to cold, bitter taste, urine is red or yellow, constipation, auditory dysesthesia etc..Primary disease is referred to as by the traditional Chinese medical science " otopyosis ", " chronic suppurative otitis media ", it is believed that be because of dampness-heat in the liver and gallbladder, pathogen is prevailing and causes, and Chinese traditional treatment otitis media has dividing of deficiency and excess, excess syndrome Cardinal symptom be that in ear feeling of distension and oppression, otalgia, red complexion be red, auditory dysesthesia, tinnitus, auditory meatus pus Huang is thick, and common have in secreted Otitis, acute suppurative otitis media and Cholesteatomatous Tympanitis and barotraumatic otits media；Acute otitis media is middle-ear mucosa Acute suppurative inflammation, course of eustachian tube infect, inflammation pharyngeal after flu, nose spreads to pharyngotympanic tube, pharyngotympanic tube swallow There is congested, swelling, ciliary movement generation obstacle in mouth and tube chamber mucosa, cause otitis media, common pathogenic bacterium to be mainly pneumonia Coccus, hemophilus influenza etc..At present, the medicine treating otitis media in prior art is typically all the west using oral anti-inflammatory type The modes such as medicine, hydrogen peroxide cleaning, serious treatment of performing an operation；Although using Western medicine to have certain therapeutic effect, but deposit The shortcoming high at medical expense, toxic and side effects is big, therefore its using effect or not ideal enough.We in clinical practice, no Disconnected summing up experience, according to theory of Chinese medical science, utilizes the Chinese herbal medicine resource of China's abundant, develops a kind of Chinese medicine system treating otitis media Agent, this Chinese medicine preparation is in clinical practice, the most evident in efficacy, and has no side effect, clinic popularization and application.

Summary of the invention

It is an object of the invention to provide a kind of Chinese medicine preparation treating otitis media.

It is an object of the invention to be achieved through the following technical solutions, the Chinese medicine preparation of this treatment otitis media is by following weight The Chinese medicine of part is made: Radix parietariae micranthae 10-14 part, Herba malachii aquatici 8-12 part, Rhizoma iridis confusae 7-11 part, Caulis Kadsurae Coccineae 3-7 part, residual withered 12- 16 parts.

Preferred: Radix parietariae micranthae 12 parts, Herba malachii aquatici 10 parts, Rhizoma iridis confusae 9 parts, Caulis Kadsurae Coccineae 5 parts, residual withered 14 parts.

Preparation method: traditionally make decoction.

Fang Zhong: Radix parietariae micranthae is drawn out the pus detumescence；Herba malachii aquatici heat-clearing and toxic substances removing, promoting blood circulation and detumescence；Rhizoma iridis confusae heat clearing and inflammation relieving；Caulis Kadsurae Coccineae connects Bone dissipating blood stasis, subduing swelling and detoxicating, promoting the circulation of QI to relieve pain；Residual withered clearing away damp-heat, detumescence poison, removing food stagnancy wind-damp dispelling.

Detailed description of the invention

Embodiment one: weigh Radix parietariae micranthae 10g, Herba malachii aquatici 8g, Rhizoma iridis confusae 7g, Caulis Kadsurae Coccineae 3g, residual withered 12g, by passing System method makes decoction.

Embodiment two: weigh Radix parietariae micranthae 12g, Herba malachii aquatici 10g, Rhizoma iridis confusae 9g, Caulis Kadsurae Coccineae 5g, residual withered 14g, by passing System method makes decoction.

Embodiment three: weigh Radix parietariae micranthae 14g, Herba malachii aquatici 12g, Rhizoma iridis confusae 11g, Caulis Kadsurae Coccineae 7g, residual withered 16g, press Traditional method makes decoction.

Toxicity test

1, laboratory animal cleaning grade healthy SD female rats 40, weight (190 ± 8) g, as chronic toxicity； The female white mice in cleaning grade health Kunming 30, weight (27 ± 3) g, as acute toxicological experiment.Feed with normal diet, general Logical drinking-water.Room temperature controls in (24 ± 2) DEG C, humidity (50 ± 4) %, natural lighting.

2, acute toxicological experiment is according to (Chinese medicine, researches on natural drugs registration service manual), selects cleaning grade health Kunming Female white mice 30, is randomly divided into 2 groups, Chinese drug-treated group and each 15 of blank group.Chinese drug-treated group is administered orally 12g/d by adult normal (being equivalent to crude drug 180g) is converted to the dosage of white mice, gavages Chinese medicine every day 1 time.Blank group gives 1mL/20g weight 0.9% sodium chloride injection gavages.

3, long term toxicity test cleaning grade healthy SD female rats 40, is randomly divided into 4 groups, Normal group and Chinese medicine Group little, in, heavy dose of each 10.Matched group gives 1ml/20g weight 0.9% sodium chloride injection, Chinese drug-treated group little, in, Heavy dose of group is that adult normal consumption is converted to the 5 of rat dosage, 15,50 times, i.e. 0.21g, 0.63g, 2.1g, be gavage to Medicine, every day 1 time, experimental period is 3 months.

4, acute toxicity testing result white mice nothing in being administered 7d is dead, to observation post administration mice outward appearance, hair color, light Pool is normal, and social behavior, reaction are all normal, ingests, drains normally.Manually put to death dissection after 7d, observe its heart, liver, spleen Dirty, lungs, kidney, brain, ovary, uterus are showed no exception.Pathological examination: dyeing in single-minded Yihong of Lignum Sappan (HE), Chinese drug-treated group is dirty Device smooth surface, in order, cell size, form are normal in organizational structure arrangement, and the dyeing of endochylema, karyon is clear, with blank group Comparing difference not statistically significant (P ＞ 0.05).

5, chronic toxicity result Chinese drug-treated group little, in, heavy dose of group and the outward appearance of rats in normal control group, hair color, Social behavior, zest etc. and to surrounding, food, the equal not statistically significant of comparing difference (P ＞ 0.05) such as interest of water. (P ＜ 0.05) is increased before the experiment of weight the most relatively this group after 4 groups of rat experiments, but the equal nothing of weight comparing difference after 4 groups of experiments Statistical significance (P ＞ 0.05), blood cytology index, blood biochemical analysis index, important organ coefficient ratio after 4 groups of rat experiments Compared with the equal not statistically significant of difference (P ＞ 0.05).At 4 groups of rats, after death important organ row staining pathologic section checks, HE dyes. In order, cell size, form are normal for the arrangement of Chinese drug-treated group Rats Organs and Tissues organizational structure, and the dyeing of endochylema, karyon is clear, with normal control Group comparing difference not statistically significant (P ＞ 0.05).

6, toxicity test shows, the Chinese medicine preparation of the treatment otitis media of the present invention has no toxic reaction after being administered.

Clinical data

1, this group of physical data case is the court out-patient 210 example, the maleest 110 examples, female 100 example；Age 18～ 58 years old, the course of disease 5～39 months, average 18 ± 1.6 months；On the basis of patient knows the inside story and be voluntary, patient is divided into 7 groups by us； Only take Radix parietariae micranthae single medicinal material group be A group, only take Herba malachii aquatici single medicinal material group be B group, only to take Rhizoma iridis confusae single medicinal material group be C Group, only take Caulis Kadsurae Coccineae single medicinal material group and be D group, only take residual withered single medicinal material group and be E group, take the present invention by embodiment two Preparation group be treatment group, employing routine treatment be matched group.Each group is compared not statistically significant in the physical data such as age, sex (P ＞ 0.05), has comparability.

2, Therapeutic Method treatment group is taken and is treated by the prepared medicament of embodiment of the present invention two；Matched group uses The roxithromycin dispersing tablet of conventional therapy otitis media is treated；Weigh the weight of A, B, C, D, E each single medicinal material group respectively, by passing The medicament that system method is made with treatment group same volume is treated, respectively the group homogeneous Zhou Weiyi course for the treatment of, and each group patient all treats two Comparitive study is carried out after the individual course for the treatment of.

3, curative effect judging standard is cured: clinical symptom disappearance, and tympanum recovery situation is good, auditory rehabilitation normal level；Aobvious Effect: clinical symptom disappearance, tympanum reverts to normal condition, the pharyngotympanic tube person of keeping clear；Take a turn for the better: clinical symptoms makes moderate progress, pharynx Tympanic canal function is improved substantially, and tympanum recovery extent is close with normal condition；Invalid: clinical symptoms is without improvement, even aggravation.

4, therapeutic outcome total effective rate includes cure rate and obvious effective rate, and result is as shown in table 1.

Group	Number of cases	Dose (g)	Recovery from illness	Take a turn for the better	Invalid	Side effect	Total effective rate (%)
								A	30	70	2	3	25	8 examples	20.0
B	30	60	0	2	28	4 examples	6.70
								C	30	60	6	1	23	6 examples	23.3
D	30	65	1	1	28	3 examples	6.70
								E	30	70	2	2	26	0 example	13.3
Treatment group	30	50	20	9	1	0 example	96.70
								Matched group	30	Convention amount	12	8	10	1 example	66.70

By above clinical data, although treatment group takes less dose, but achieve and preferably treat effect Really, total effective rate is higher than each single medicinal material total effective rate sum, also significantly better than matched group, more the good news is that toxicity reduces, nontoxic Side effect occurs, it follows that each medicine develops to the direction of beneficially human health under synergistic function, clinic pushes away Wide application.

When following up a case by regular visits to above patient, " after taking the preparation of the present invention, not only otitis media obtains wherein 3 example readmes Arrived rehabilitation, and night sweat symptom might as well ".After obtaining this message, we suffer from night sweat in various degree immediately and suffer from 20 examples Person, uses the Chinese medicine preparation that embodiment of the present invention two prepares, and every day, potion, divided the method sooner or later taken for twice to be treated, According to curative effect judging standard: recovery from illness refers to that night sweat stops completely, and concomitant symptom disappears substantially, nothing recurrence in 1 year after drug withdrawal；Effective finger is stolen Antiperspirant stops substantially, and concomitant symptom has been alleviated, nothing recurrence in 6 months after drug withdrawal；Invalid finger night sweat and concomitant symptom are all without improving.Knot Fruit is in 20 example patients, and 12 examples of fully recovering (60%), effective 8 examples (40%), invalid 0 example, total effective rate is calculated as with effective by recovery from illness 100%.It follows that take the Chinese medicine preparation of the present invention, not only treatment otitis media is evident in efficacy, and has night sweat very well Therapeutic effect, clinic popularization and application.

Claims

1. the Chinese medicine preparation treating otitis media, it is characterised in that this Chinese medicine preparation is made up of the Chinese medicine of following weight portion: wall Grass roots 10-14 part, Herba malachii aquatici 8-12 part, Rhizoma iridis confusae 7-11 part, Caulis Kadsurae Coccineae 3-7 part, residual withered 12-16 part.

A kind of Chinese medicine preparation treating otitis media, it is characterised in that this Chinese medicine preparation is by following heavy Amount part Chinese medicine make: Radix parietariae micranthae 12 parts, Herba malachii aquatici 10 parts, Rhizoma iridis confusae 9 parts, Caulis Kadsurae Coccineae 5 parts, residual withered 14 parts.