CN104147499A - Traditional Chinese medicine composition for treating spleen-stomach damp-heat type chronic gastritis and preparation method thereof - Google Patents

Abstract

The invention discloses a traditional Chinese medicine composition for treating spleen-stomach damp-heat type chronic gastritis and a preparation method thereof. The traditional Chinese medicine composition comprises the following raw medicinal materials: reed rhizome, radix scutellariae, coptis chinensis, root of chinese barberry, rhizoma imperatae, silkworm excrement, papaya, berba aristolochiae mollissimae, caulis sinomenii, erodium stephanianum willd, white hyacinth bean, agastache rugosus, herba eupatorii, cardamom, abrus cantoniensis hance, radix aristolochiae, paederia scandens, betel nut, lignum dalbergiae odoriferae, rhizoma fagopyri dibotryis, plum kernel, alysicarpus vaginalis, Chinese soapberry fruit, tea oil, herba urariae cnnita, fructus amomi, rhizoma cyperi, valerianae jatamansi rhizoma, potamogeton distinctus root, radix angelicae tuhuo, pummelo peel, a distilled liquid of oval kumquat fruit, and all-grass of swamp cudweed. The traditional Chinese medicine composition has the efficacies of clearing heat and resolving dampness, and regulating qi and middle warmer, and is used for treating spleen-stomach damp-heat type chronic gastritis. With utilization of the theory of traditional Chinese medicine and based on a holistic view, the traditional Chinese medicine composition performs syndrome differentiation and treatment, has stronger pertinence, is obvious in curative effects, can eradicate helicobacter pylori, protects gastric mucosa, relieves pain, does not easily produce drug resistance, reduces recurrence, reduces the complication rate, improves the cure rate, and meets clinical market needs.

Description

A kind of Chinese medicine composition for the treatment of spleen and stomach damp-heat type chronic gastritis and preparation method thereof

 

Technical field

The present invention relates to contain the medicinal preparation that derives from plant, animal or mineral component, particularly a kind of Chinese medicine composition for the treatment of spleen and stomach damp-heat type chronic gastritis and preparation method thereof.

 

Background technology

The pathological change of chronic gastritis, is confined to mucous layer substantially, therefore strictly says and should be referred to as " chronic gastric mucositis " or " gastric mucosa disease ".According to the record of Schindler, " chronic gastritis " is that first Stahl proposed in 1728, constantly reports to some extent thereafter.But be there is all the time to difference in this diagnosis.Especially after Cruveilhier in 1830 finds gastric ulcer, for the patient who has epigastrium pain, be often diagnosed as Peptic Ulcers or stomach neurosis and do not diagnose gastritis.Until 1932, Schindler can directly observe gastric mucosa variation preferably with bending gastroscope, after getting mucosa group inspection alive with operating gastroscope again, the diagnosis of gastritis has just been improved to a step.He is divided into constitutional and Secondary cases two classes chronic gastritis, and primary gastritis is divided into again 3 kinds of shallow, atrophic and plumpnesses.

Etiology and pathology: now clear and definite Hp infects the topmost cause of disease for chronic gastritis, and someone is referred to as Hp Gastritis.But the prolonged and repeated susceptible human body that acts on of other physical properties, chemical and biological harmful factor also can cause primary disease.Cause of disease sustainable existence or repeatedly generation can form chronic disease.Think that at present chronic gastritis is to be caused by many factors effect.1.Hp causes that the main mechanism of gastritis has the following aspects: (1) Hp twist, has flagellum structure, can free swimming in slime layer.(2) Hp has target position on mucus, can be combined with the glycoprotein of epithelial cell and mucus and glycolipid target position.(3) with mucosa cells close contact, (attachment pedestal) spline structure that can " contact base " with epithelial cell, and microvillus is come off, cytoskeleton destroys.(4) produce plurality of enzymes and metabolite, as urease and product ammonia thereof, superoxide dismutase, protein resolvase, phospholipase A2 and C.(5) cytotoxin (cytotoxin) can cause the vacuolar degeneration of cell.(6) Hp causes after infecting that gastric epithelial cell discharges IL-1, the factors such as cytokine and TNF2 such as 8, causes neutrophilic granulocyte from blood vessel internal migration to Weishang Pi Chu and is activated, and it can discharge metabolite and protein resolvase, makes Gastric mucosal lesion.It can also cause the activation such as mononuclear cell, basophil, oxyphil cell simultaneously, further increases the weight of the infringement of gastric mucosa.(7) after immunoreation: Hp infects, can and bring out the autoimmune response of body by cellular immunization, humoral immunization (generation antibody), cause or add the formation of hypergastritis.2. inherited genetic factors: the genetic predisposition of human body plays a role in chronic gastritis morbidity.3. the age: clinical statistics result shows that generation and the age of chronic gastritis are significant positive correlation.Age is larger, gastric mucosa function, and " resistance " is also poorer, is easily subject to the impact of extraneous unfavorable factor and causes damage.4. smoking: the incidence rate of serious smoker's gastritis can raise.5. drink: Beaumont observes ethanol the earliest by gastric fistula patient can make gastric mucosa produce lamellar flushing, has also confirmed this point again later, but recover after stopping drinking by gastroscopic observation.6. food stimulus: various condiment and irritable food can promote the secretion of gastric acid, but fail to prove to cause chronic gastritis.7. medicine: NSAID (non-steroidal anti-inflammatory drug) class (NSAIDs) can cause gastric mucosal erosion as aspirin and Phenylbutazone, can leave over chronic gastritis after rotten to the corn healing.9. Metal Contact: plumbous work operations person's Mechanism of Gastric Ulcer rate is high, finds that to gastric mucosa biopsy atrophic gastritis sickness rate also increases according to author.10. temperature: supercool overheated food or beverage or the ice water gastric lavage that is used for the treatment of object all can cause mucosal lesion.

Symptom and sign: the modal symptom of chronic gastritis is Upper abdominal pain and glutted.Contrary with Peptic Ulcers pleasant on an empty stomach, uncomfortable after meal, may be because of the diastolic dysfunction of holding, though the few feel satiety of feed.Patient often tells " stomach is weak " or " stomach is soft ".Often because of cold drinks and snachs, hard food, pungent or other irritable foods cause symptom or symptom is increased the weight of.These symptoms are difficult for alleviating by antacid and spasmolytic.Most patients tell inappetence.The inconsistent reason of symptom and biopsy has two probabilities: 1. blindly biopsy fails to get diseased region, under fibergastroscope direct-view at present, does biopsy, and positive rate has reached 80%～90%; 2. symptom not derives from stomach, may cause due to hepatobiliary system disease.The problem of asymptomatic " Healthy People " biopsy positive, must diagnose gastritis in addition.Because a lot of diseases can be asymptomatic or symptom is slight as Peptic Ulcers, liver cirrhosis, hepatocarcinoma and pulmonary carcinoma etc., pass through physical examination and be just found.Therefore part Gastritis is asymptomatic and not at all surprising.

Inspection method: lab testing: 1. gastric acid: superficial gastritis gastric acid is normal or lower slightly, atrophic gastritis obviously reduces, on an empty stomach normal anacidity.2. pepsinogen: secreted by chief cell, all can record in gastric juice, blood and urine.Protease level height is basic parallel with gastric acid.But chief cell is more than parietal cell quantity, so in the time of morbid state, gastric acid secretion is usually lower than the secretion of pepsinogen.3. intrinsic factor (IF): IF is secreted by parietal cell, parietal cell reduces IF secretion and also reduces, and both are strict parallel.4. gastrin: gastrin is secreted by G cell in gastric antrum.5. parietal cell antibody (PCA): PCA is higher at the positive rate of A type gastritis, the detection of this antibody contributes to the typing of chronic gastritis, to chronic gastritis occur pathological process understanding and treat helpful.6. gastrin secretion cell antibody (GCA).

Other auxiliary examinations: 1. gastroscopy: Sydney categorizing system has been made a series of regulation to gastroscopic descriptor, comprise edema, erythema, fragility, ooze out, flat erosion, protuberance erosion, tuberosity, pleat hypertrophy, pleat atrophy, blood vessel thoroughly sees and petechia is described.2.X ray examination: superficial gastritis x-ray is found without the positive.The visible pleat of atrophic gastritis tiny or disappear, hypotension.

Chinese medicine thinks, chronic gastritis belongs to the categories such as motherland's medical science " stomachache ", " feeling of fullness ", " vomiting ", " singultus ".Stomachache is due to gastric qi retardance, stomach network stasis blocking, and stomach is become homeless foster, and there is a kind of taste enteropathy card of pain as primary symptom taking upper abdomen gastral cavilty portion in what stagnation of QI and blood may bring about pain caused.Stomachache, claims again gastric abscess.

Etiology and pathogenesis: the cause of disease of stomachache is mainly diseases caused by exogenous pathogenic factor cold-evil, injury due to diet, feelings will is unsuccessful, weakness of the spleen and stomach etc.1. cold-evil visitor cold syndrome of the stomach belongs to YIN pathogen, its property spasm that stagnates.2. the diet stomach receiving food and drink digesting food that injures one's stomach, its gas with reduce to suitable, therefore generation and the eating and drinking without temperance relation of stomachache are the closest.Hyperactive liver-QI attacking the stomach taste received transporting, the lifting of middle burnt mechanism of qi, depends on the catharsis of liver, " Plain Questions, a precious life holotype opinion section " said " earth being dredged by wood " means this.4. weakness of the spleen and stomach spleen and stomach phase the exterior and the interior, with placed in the middle burnt, play altogether and is received the merit of transporting and transforming nutrients from foodstuff.Determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs: 1, cold-evil visitor stomach symptom: stomachache is done cruelly, and very contracture is had a pain, pain alleviated while getting warmth, pain increase in intensity under coldness, tastelessness and no thirst, or desire for hot drinks, white and thin fur, stringy and tense pulse.2, retention of food and drink symptom: after eating and drinking too much at one meal, gastralgia, distension does not disappear, and pain with tenderness obtains food more very, belching and acid regurgitation, or vomiting indigestion food, its taste is rancid, tells rear alleviation of pain, anorexia or anorexia, defecate not well, must vow gas and slightly easypro after an action of the bowels, thick fur is greasy, and rolling pulse is strong.3, hyperactive liver-QI attacking the stomach symptom: gastral cavilty distension, to attack support and have a pain, gastralgia connects the side of body, belch uncomfortable in chest, the happiness breath of sighing, defecate not smooth, obtains belch, vows that gas relaxes, and meets that worried disgruntled pain is done or bitterly very, white and thin fur, stringy pulse.4, syndrome of liver-stomach heat symptom: burning pain in the epigastrium, pain gesture is urgent, likes cold aversion to heat, obtain coolly to relax, susceptible to lose temper due to restlessness, pantothenic acid is noisy, dry mouth with bitter taste, the few tongue of red tongue, wiry and frequent pulse.5, blood stasis is stagnated symptom: gastralgia, and aching as needle stabbing lancinates, localized pain, the pain of pressing very, is aggravated after food, becoming severe at night, or see haematemesis, melena, purplish tongue or have ecchymosis, hesitant pulse.6, damp-heat in the spleen and stomach symptom: the scorching hot pain of gastral cavilty, noisy pantothenic acid, dry mouth with bitter taste, thirst but no desire to drink, sweet taste in the mouth is sticky turbid, and food sweet food emits sour water, and indigestion and loss of appetite nauseating, heavy sensation of the body limb is tired, and urine yellow skin is defecated not smooth, yellowish fur, the sliding number of pulse condition.7, stomach-Yin virtual loss symptom: the indistinct causalgia of gastral cavilty, like famine and loss of appetite, dryness of the mouth and throat, thirsty think of drink, becomes thin weak, constipation with dry stool, red tongue with a little fluid or light stripping no fur, thready and rapid pulse.8, Deficiency and coldness of spleen and stomach symptom: indistinctly, endlessly continuous, cold type of pain discomfort, likes warm cream and press in stomachache, and pain of empty stomach very, must eat slow, tired or eat cold or suffer from cold after pain outbreak or increase the weight of general vomiting watery fluid, lack of appetite, spiritlessness and weakness, hands and feet being not warm, large loose stool is thin, pale tongue with white fur, deficient and weak pulse.

Western medical treatment chronic gastritis: 1. avoid causing the factor of acute gastritis, avoid taking to stomach food excitatory and medicine as NSAID etc. as given up tobacco and wine.2. Diet Therapy: principle is similar to Peptic Ulcers, repeatedly eats less, and soft diet is main, avoids raw food and irritable food, the more important thing is according to patient's dietary habit and many years of experience, sums up a set of recipe that is applicable to oneself.3. Drug therapy: Hp Gastritis need be eradicated the treatment of Hp, can give dilute hydrochloric acid and pepsin in right amount.But chronic gastritis there is no specific short, generally advocate that asymptomatic person is without treating.After some therapeutic scheme drug withdrawal, Hp breeding once again very soon, easily produces drug resistance, causes disease relapse etc.

But Chinese medicine chronic gastritis possesses unique advantage and feature.Chinese medicine utilizes Traditional Chinese medical theory, on the basis of Overall View, carries out determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs; carry out " treating different diseases with the same therapeutic principle " according to similar disease, similar according to clinical manifestation, the clinical stage that disease is different will carry out " treating the same disease with different methods "; specific aim is stronger, evident in efficacy, can eliminating pylorus; protection gastric mucosa, alleviating pain, is difficult for producing drug resistance; reduce recurrence, reduce coincidence, improve cure rate; improve patient's quality of life, can carry out clinical market development, meet the demand in clinical market.

 

Summary of the invention

Technical problem to be solved by this invention is, provides one to have clearing away heat and eliminating dampness, and regulating the flow of Qi and the middle Jiao effect cures mainly the Chinese medicine composition of chronic gastritis syndrome of dampness-heat of spleen and stomach.The present invention utilizes Traditional Chinese medical theory, on the basis of Overall View, carries out determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs; carry out " treating different diseases with the same therapeutic principle " according to similar disease, similar according to clinical manifestation, the clinical stage that disease is different will carry out " treating the same disease with different methods "; specific aim is stronger, evident in efficacy, can eliminating pylorus; protection gastric mucosa; alleviating pain, is difficult for producing drug resistance, reduces coincidence; improve cure rate, meet the demand in clinical market.

For solving the problems of the technologies described above, the invention provides a kind of Chinese medicine composition for the treatment of spleen and stomach damp-heat type chronic gastritis, comprise following raw medicinal material: Rhizoma Phragmitis, Radix Scutellariae, Rhizoma Coptidis, Radix Berberidis, Rhizoma Imperatae, Bombyx mori L., Fructus Chaenomelis, Herba Aristolochiae Mollissimae, Caulis Sinomenii, geranium, Semen Lablab Album, Herba Pogostemonis, Herba Eupatorii, Fructus Amomi Rotundus, Herba Abri, Radix Aristolochiae, fevervine, Semen Arecae, Lignum Dalbergiae Odoriferae, Rhizoma Fagopyri Dibotryis, Semen Mume, Canis familiaris L. ant grass, Fructus Sapindi Mukouossi, Oleum Camelliae, Herba Urariae crinitae, Fructus Amomi, Rhizoma Cyperi, Rhizoma valerianae latifoliae, Herba potamogetonis distincti's root, Radix Angelicae Pubescentis, Exocarpium Citri Grandis, Liquor Fructus Fortunellae Distillata, Herba Gnaphalii uliginosi.

In described Chinese medicine composition, the ratio of weight and number of each raw medicinal material is: Rhizoma Phragmitis 10-30 weight portion, Radix Scutellariae 12-25 weight portion, Rhizoma Coptidis 10-20 weight portion, Radix Berberidis 4-9 weight portion, Rhizoma Imperatae 10-20 weight portion, Bombyx mori L. 13-28 weight portion, Fructus Chaenomelis 10-28 weight portion, Herba Aristolochiae Mollissimae 10-25 weight portion, Caulis Sinomenii 10-30 weight portion, geranium 10-27 weight portion, Semen Lablab Album 15-26 weight portion, Herba Pogostemonis 6-10 weight portion, Herba Eupatorii 10-20 weight portion, Fructus Amomi Rotundus 15-30 weight portion, Herba Abri 10-24 weight portion, Radix Aristolochiae 7-10 weight portion, fevervine 12-24 weight portion, Semen Arecae 10-20 weight portion, Lignum Dalbergiae Odoriferae 6-10 weight portion, Rhizoma Fagopyri Dibotryis 14-29 weight portion, Semen Mume 10-20 weight portion, Canis familiaris L. ant grass 15-30 weight portion, Fructus Sapindi Mukouossi 12-26 weight portion, Oleum Camelliae 10-20 weight portion, Herba Urariae crinitae 15-26 weight portion, Fructus Amomi 10-30 weight portion, Rhizoma Cyperi 14-25 weight portion, Rhizoma valerianae latifoliae 15-27 weight portion, the root 10-25 of Herba potamogetonis distincti weight portion, Radix Angelicae Pubescentis 10-30 weight portion, Exocarpium Citri Grandis 10-26 weight portion, Liquor Fructus Fortunellae Distillata 14-30 weight portion and Herba Gnaphalii uliginosi 10-20 weight portion.

In described Chinese medicine composition, the ratio of weight and number of each raw medicinal material is: Rhizoma Phragmitis 20-30 weight portion, Radix Scutellariae 12-20 weight portion, Rhizoma Coptidis 15-20 weight portion, Radix Berberidis 4-5 weight portion, Rhizoma Imperatae 15-20 weight portion, Bombyx mori L. 23-28 weight portion, Fructus Chaenomelis 20-28 weight portion, Herba Aristolochiae Mollissimae 15-25 weight portion, Caulis Sinomenii 20-30 weight portion, geranium 15-27 weight portion, Semen Lablab Album 15-20 weight portion, Herba Pogostemonis 6-7 weight portion, Herba Eupatorii 15-20 weight portion, Fructus Amomi Rotundus 25-30 weight portion, Herba Abri 10-20 weight portion, Radix Aristolochiae 7-8 weight portion, fevervine 15-24 weight portion, Semen Arecae 15-20 weight portion, Lignum Dalbergiae Odoriferae 6-8 weight portion, Rhizoma Fagopyri Dibotryis 14-20 weight portion, Semen Mume 15-20 weight portion, Canis familiaris L. ant grass 25-30 weight portion, Fructus Sapindi Mukouossi 22-26 weight portion, Oleum Camelliae 15-20 weight portion, Herba Urariae crinitae 15-20 weight portion, Fructus Amomi 20-30 weight portion, Rhizoma Cyperi 14-20 weight portion, Rhizoma valerianae latifoliae 15-20 weight portion, the root 15-25 of Herba potamogetonis distincti weight portion, Radix Angelicae Pubescentis 20-30 weight portion, Exocarpium Citri Grandis 15-26 weight portion, Liquor Fructus Fortunellae Distillata 24-30 weight portion and Herba Gnaphalii uliginosi 15-20 weight portion.

In described Chinese medicine composition, the ratio of weight and number of each raw medicinal material is: Rhizoma Phragmitis 15 weight portions, Radix Scutellariae 25 weight portions, Rhizoma Coptidis 10 weight portions, Radix Berberidis 9 weight portions, Rhizoma Imperatae 12 weight portions, Bombyx mori L. 18 weight portions, Fructus Chaenomelis 18 weight portions, Herba Aristolochiae Mollissimae 14 weight portions, Caulis Sinomenii 15 weight portions, geranium 14 weight portions, Semen Lablab Album 24 weight portions, Herba Pogostemonis 8 weight portions, Herba Eupatorii 14 weight portions, Fructus Amomi Rotundus 20 weight portions, Herba Abri 24 weight portions, Radix Aristolochiae 9 weight portions, fevervine 14 weight portions, Semen Arecae 14 weight portions, Lignum Dalbergiae Odoriferae 9 weight portions, Rhizoma Fagopyri Dibotryis 29 weight portions, Semen Mume 14 weight portions, Canis familiaris L. ant grass 20 weight portions, Fructus Sapindi Mukouossi 16 weight portions, Oleum Camelliae 14 weight portions, Herba Urariae crinitae 26 weight portions, Fructus Amomi 18 weight portions, Rhizoma Cyperi 25 weight portions, Rhizoma valerianae latifoliae 25 weight portions, Herba potamogetonis distincti's root 14 weight portions, Radix Angelicae Pubescentis 17 weight portions, Exocarpium Citri Grandis 14 weight portions, Liquor Fructus Fortunellae Distillata 20 weight portions and Herba Gnaphalii uliginosi 14 weight portions.

In described Chinese medicine composition, the ratio of weight and number of each raw medicinal material is: Rhizoma Phragmitis 25 weight portions, Radix Scutellariae 18 weight portions, Rhizoma Coptidis 20 weight portions, Radix Berberidis 5 weight portions, Rhizoma Imperatae 15 weight portions, Bombyx mori L. 23 weight portions, Fructus Chaenomelis 25 weight portions, Herba Aristolochiae Mollissimae 20 weight portions, Caulis Sinomenii 25 weight portions, geranium 17 weight portions, Semen Lablab Album 18 weight portions, Herba Pogostemonis 6 weight portions, Herba Eupatorii 20 weight portions, Fructus Amomi Rotundus 25 weight portions, Herba Abri 15 weight portions, Radix Aristolochiae 7 weight portions, fevervine 20 weight portions, Semen Arecae 18 weight portions, Lignum Dalbergiae Odoriferae 6 weight portions, Rhizoma Fagopyri Dibotryis 18 weight portions, Semen Mume 20 weight portions, Canis familiaris L. ant grass 28 weight portions, Fructus Sapindi Mukouossi 26 weight portions, Oleum Camelliae 20 weight portions, Herba Urariae crinitae 18 weight portions, Fructus Amomi 27 weight portions, Rhizoma Cyperi 18 weight portions, Rhizoma valerianae latifoliae 18 weight portions, Herba potamogetonis distincti's root 25 weight portions, Radix Angelicae Pubescentis 26 weight portions, Exocarpium Citri Grandis 26 weight portions, Liquor Fructus Fortunellae Distillata 27 weight portions and Herba Gnaphalii uliginosi 18 weight portions.

In order to solve the problems of the technologies described above, the present invention also provides a kind of preparation method of described Chinese medicine composition, and when the dosage form of described Chinese medicine composition is oral solutions, its preparation method is:

The first step, Rhizoma Phragmitis, Radix Scutellariae, Rhizoma Coptidis, Radix Berberidis and Rhizoma Imperatae are mixed, the alcohol reflux that to add with respect to 2 times～4 times, mixture amount determining alcohols be 75%～80% 2 times～4 times, each 2 hours～3 hours, filter, filtrate merges, and reclaims ethanol, be concentrated into the mastic that 70 DEG C of relative densities are 1.20～1.22, for subsequent use;

Second step, is mixed in proportion described residue raw medicinal material, adds with respect to 3～5 times of water gagings of mixture, boils 2～4 hours, filters, and is concentrated into the mastic that 70 DEG C of relative densities are 1.21～1.24;

The 3rd step, the described mastic that the first step, second step are obtained mixes, and 55 DEG C～65 DEG C reduced vacuum are dry, and powder gets dry extract;

The 4th step, will the 3rd add ethanol in the described dried cream powder that obtains of step, obtain containing alcohol mastic, and described is 75%～80% containing alcohol mastic containing alcohol amount; Carry out successively cold preservation processing, precipitation process, filtration treatment, recovery Ethanol Treatment by described containing alcohol mastic, obtain dealcoholysis mastic, wherein, the cold preservation processing time is 30～40 hours;

The 5th step, will add cane sugar powder, active carbon in described dealcoholysis mastic, carries out successively heat treated, filtration treatment, dilution process, obtains semi-finished product; The weight ratio of described dealcoholysis mastic and described cane sugar powder is 1: 0.12～0.3; The weight ratio of described dealcoholysis mastic and described active carbon is 1: 0.001～0.002; The time of described heat treated is 30～40 minutes, and temperature is 100 DEG C～110 DEG C;

The 6th step, the more described semi-finished product of the 5th step acquisition are carried out to filtration treatment, embedding processing, sterilization treatment successively, obtain described Chinese medicine preparation oral liquid finished product.

When the dosage form of described Chinese medicine composition is syrup, its preparation method is:

The first step, Rhizoma Phragmitis, Radix Scutellariae, Rhizoma Coptidis, Radix Berberidis, Rhizoma Imperatae, Bombyx mori L., Fructus Chaenomelis, Herba Aristolochiae Mollissimae, Caulis Sinomenii, geranium, Semen Lablab Album and Herba Pogostemonis are mixed in described ratio, use the dissolve with ethanol with respect to the determining alcohol 80%～90% of 2～4 times of the mixture quality obtaining, reflux was extracted after 2～4 hours, filter, obtain the first filtrate; Filtering residue is used to the dissolve with ethanol with respect to the determining alcohol 80%～90% of 1～2 times of the mixture quality obtaining again, and reflux was extracted after 1～2 hour, filtered, and obtained the second filtrate; Merge the first filtrate and the second filtrate, decompression recycling ethanol to be concentrated into liquor strength be 0.7～0.9g crude drug/mL, utilize the macroporous adsorptive resins eluting that volume is 5L, first use deionized water or the distilled water eluting of 6 times of resin column volumes, be 90%～95% ethanol elution with the determining alcohol of 3 times of resin column volumes again, collect ethanol elution, concentrating under reduced pressure is removed ethanol, is dried and is ground into powder;

Second step, Herba Eupatorii, Fructus Amomi Rotundus, Herba Abri and Radix Aristolochiae are mixed in described ratio, add with respect to obtain mixture quality the determining alcohol 85%～90% of 2～4 times alcohol heating reflux extract 1～2 time, extracting solution merges, with the centrifugal remove impurity of tube centrifuge, the mastic that when extracting solution after remove impurity is evaporated to 60 DEG C under the condition of 65 DEG C～70 DEG C, relative density is 1.22～1.25, is dried to powder by the mastic after concentrated with spray dryer;

The 3rd step, mixes surplus stock medical material in described ratio, add the water dissolution of 2～4 times with respect to the mixture quality obtaining, and heating decocts 2～3 hours, filters; Filtering residue is used to the water dissolution of 1～2 times with respect to the mixture quality obtaining again, and heating decocts 1～2 hour, filters; Merge the filtrate of twice, concentrating under reduced pressure is removed moisture, is dried and is ground into powder;

The 4th step, the powder that the first step, second step and the 3rd step are obtained mixes, add the water dissolution with respect to 1.5～3 times of mixture qualities, with 50% sodium hydroxide solution adjusting pH value to 7.0, stir evenly cold preservation 48 hours～72 hours under 10 DEG C～14 DEG C conditions, filter, filtrate adds the sucrose with respect to 0.3～0.4 times of the mixture quality obtaining, and stirs and dissolves, and regulates pH value to 7.0, add water appropriate, stir, static 12～20 hours, filter, fill, sterilizing, obtains syrup, and the crude drug concentration in described syrup is 1.2 g/mL～1.5g/mL.

The dosage form of described Chinese medicine composition is: sugar coated tablet, film coated tablet, enteric coated tablet, hard capsule, soft capsule, oral liquid, suck agent, granule, electuary, honey pill agent, powder, sublimed preparation, solution, injection, suppository, plaster, syrup, powder and patch.

Described Chinese medicine composition, medicine is decocted in use decoction and is taken, and 1 dose of every day, decocting takes at twice, and every 7 days is a course for the treatment of; In the time that this Chinese medicine composition is honey pill agent, tablet use, 2 times on the one, every 7 days is a course for the treatment of; In the time that this Chinese medicine composition is oral liquid use, 3 times on the one, every 7 days is a course for the treatment of.

The invention has the beneficial effects as follows: the present invention has clearing away heat and eliminating dampness that effect of regulating the flow of Qi and the middle Jiao is used for the treatment of various chronic gastritis syndrome of dampness-heat of spleen and stomach.The present invention utilizes Traditional Chinese medical theory, on the basis of Overall View, carries out determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs; carry out " treating different diseases with the same therapeutic principle " according to similar disease, similar according to clinical manifestation, the clinical stage that disease is different will carry out " treating the same disease with different methods "; specific aim is stronger, evident in efficacy, can eliminating pylorus; protection gastric mucosa, alleviating pain, is difficult for producing drug resistance; reduce coincidence, improve cure rate, treatment is fast; good effect, is free from side effects, and meets the demand in clinical market.

 

Detailed description of the invention

Chinese medicine thinks, primary disease is often by diseases caused by exogenous pathogenic factor cold-evil, and diet injures one's stomach, and feelings will is unsuccessful, weakness of the spleen and stomach, and due to the cause of disease such as the stagnation of QI, blood stasis, phlegm retention, can a kind of cause of disease cause a disease separately, also can Different types of etiopathogenises jointly cause a disease.Diseased region is mainly at stomach, in close relations with liver spleen, also relevant with gallbladder kidney.Basic pathogenesis is gastric qi retardance, stomach network stasis blocking, and stomach is become homeless foster, stagnation of QI and blood may bring about pain.At the beginning of primary disease, pathogenesis is more simple, mostly is cold-evil visitor stomach, retention of food and drink, hyperactive liver-QI attacking the stomach, syndrome of liver-stomach heat, damp-heat in the spleen and stomach etc., true card; Often Sthenia is transforming into asthenia for a long time, and see Deficiency and coldness of spleen and stomach, deficiency of stomach-Yin etc., belongs to deficiency syndrome.Also there is the onset person that sees Deficiency and coldness of spleen and stomach, also belong to deficiency syndrome.Disease causes void because of real for a long time, or excess caused by deficiency, and many factors influences each other, the complicated syndrome that can form cold and heat and asthenia and sthenia and see.Dialectical aspect to be to distinguish cold, hot, empty, real, and is main points at gas, at blood, in method for the treatment of often taking Activating Qi and regulating stomach to relieve pain as basic principle.Should abide by saying of Ye Tianshi " far away just with soft " and " avoiding firm use soft ", regulate the flow of vital energy and can not damage stomach-Yin.Primary disease prognosis is generally better, lapse to mainly contain the long-pending piece of gastral cavilty and have blood in stool, haematemesis etc.To stomachache patient, taking good care of oneself of lay special stress on diet and spiritual aspect, it is treatment and prevents indispensable measure.

Therefore, the present invention treats chronic gastritis syndrome of dampness-heat of spleen and stomach, with clearing away heat and eliminating dampness, regulating the flow of Qi and the middle Jiao is primary treatment principle, selects prescription: Rhizoma Phragmitis, Radix Scutellariae, Rhizoma Coptidis, Radix Berberidis, Rhizoma Imperatae, Bombyx mori L., Fructus Chaenomelis, Herba Aristolochiae Mollissimae, Caulis Sinomenii, geranium, Semen Lablab Album, Herba Pogostemonis, Herba Eupatorii, Fructus Amomi Rotundus, Herba Abri, Radix Aristolochiae, fevervine, Semen Arecae, Lignum Dalbergiae Odoriferae, Rhizoma Fagopyri Dibotryis, Semen Mume, Canis familiaris L. ant grass, Fructus Sapindi Mukouossi, Oleum Camelliae, Herba Urariae crinitae, Fructus Amomi, Rhizoma Cyperi, Rhizoma valerianae latifoliae, Herba potamogetonis distincti's root, Radix Angelicae Pubescentis, Exocarpium Citri Grandis, Liquor Fructus Fortunellae Distillata, Herba Gnaphalii uliginosi.

Wherein, Rhizoma Phragmitis, Radix Scutellariae, Rhizoma Coptidis, Radix Berberidis heat clearing and damp drying; Rhizoma Imperatae, Bombyx mori L., Fructus Chaenomelis, Herba Aristolochiae Mollissimae, Caulis Sinomenii, geranium/Semen Mume, Canis familiaris L. ant grass, Fructus Sapindi Mukouossi, Oleum Camelliae, Herba Urariae crinitae, Fructus Amomi, Rhizoma Cyperi clearing away damp-heat, removing toxic substances pain relieving; The removing dampness of Semen Lablab Album stomach function regulating; Herba Pogostemonis, Herba Eupatorii, Fructus Amomi Rotundus, Herba Abri clearing heat and expelling damp; Radix Aristolochiae, fevervine, Semen Arecae, Lignum Dalbergiae Odoriferae, Rhizoma Fagopyri Dibotryis, Rhizoma valerianae latifoliae, Herba potamogetonis distincti's root, Radix Angelicae Pubescentis, Exocarpium Citri Grandis, Liquor Fructus Fortunellae Distillata, Herba Gnaphalii uliginosi regulating qi-flowing for strengthening spleen, relieving pain by regulating middle-JIAO.Full side's compatibility is rigorous, can eliminating pylorus, and gastric mucosa reparation, regulating QI to relieve pain etc., evident in efficacy, safe and effective, improve cure rate, reduce relapse rate etc.

Now each taste Chinese medicine is described below:

Rhizoma Phragmitis: sweet, cold; Return lung meridian, stomach warp." property of medicine opinion ": " can separate large heat, appetizing.Control the sound of vomiting of choking more than." " Japan hanako materia medica ": " and disease unhappiness while controlling cold and heat, good pregnant people's heat in the heart, and dysentery people is thirsty." clearing away heat and promoting production of body fluid, relieving restlessness, preventing or arresting vomiting, diuresis.Cure mainly: for calentura excessive thirst, gastropyretic vomiting, cough due to lung-heat, lung abscess vomiting pus, the puckery pain of pyretic stranguria.Rhizoma Phragmitis is for gastropyretic vomiting.Rhizoma Phragmitis can clearing heat to ease the stomach preventing or arresting vomiting, does not grow again the greasy stomach that hinders, therefore the key medicine of vomitting the sound of vomiting for controlling gastric heat.The lighter is alone, and severe one is often joined Caulis Bambusae In Taenia, Rhizoma Zingiberis Recens, Semen oryzae sativae etc., to strengthen heat clearing away sending down the abnormal ascending QI, and the merit of middle preventing or arresting vomiting, side is as Thousand Golden Prescriptions Rhizomatis Phragmitis Potion.Can suppress the caused contractile response of electricity irritation of frog neuromuscular specimen and the picked-up of the oxygen of diaphragm in rats and anaerobic glycolysis, in vitro Cavia porcellus intestinal tube is had to relexation.

Radix Scutellariae: property hardship, cold.Return lung, gallbladder, spleen, large intestine, small intestine meridian." book on Chinese herbal medicine converges and says ": " clear flesh is brought down a fever, and Radix Bupleuri the best, so can not reach table by cool flesh without Radix Scutellariae.The fire of the part of the body cavity above the diaphragm housing the heart and lungs, mountain mast can fall, and so gives up Radix Scutellariae and can not go up refresh oneself.So Fang Mai section with clear flesh bring down a fever, speciality of carbuncle and ulcers with removing toxic substances and promoting granulation, bright section with heat radiation improving eyesight, women section is with it antiabortive reason warp, agent also first of Ci Gaizhu section half exterior and half interior." can heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive, blood pressure lowering.For hygropyrexia, fever disease in summer vomiting and nausea uncomfortable in chest, damp and hot feeling of fullness, dysentery, jaundice, cough due to lung-heat, high hot excessive thirst, heat in blood is told nosebleed, carbuncle sore tumefacting virus, frequent fetal movement.That Radix Scutellariae has is antipyretic, calm, blood pressure lowering, diuresis, reduction capillary permeability, suppress the effects such as intestinal tube wriggling, staphylococcus, blood dissolubility streptococcus, Diplococcus pneumoniae, Bacillus typhi, dysentery coccus, newcastle, bacillus pyocyaneus are had to certain inhibitory action, upper respiratory tract infection, chronic bronchitis, bacillary dysentery etc. are had to good curative effect.

Rhizoma Coptidis: hardship, cold, nontoxic.GUIXIN, spleen, stomach, liver, gallbladder, large intestine channel." Yaoxing Fu ": " bitter in the mouth, flat, gas is cold, nontoxic.Sink also, the moon also.It is with having four: eliminating heart-fire, the shape of the epigastric fullness that disappears; Main intestinal Bleach is red except what mix in intestinal; Control order disease and break out suitable use, treat skin infection head and the tail all same." function heat clearing and damp drying, eliminating fire and detoxication.For damp and hot feeling of fullness, vomiting acid regurgitation, dysentery, jaundice, unconsciousness due to high fever, is longer than the fire of removing pathogen in the heart stomach, has the disappear merit of painful abdominal mass of preventing or arresting vomiting concurrently, can be used for treating the dysphoria and insomnia of heart-fire due to prosperous, and heat in blood is told nosebleed, conjunctival congestion, toothache, quenches one's thirst, carbuncle furuncle; External treatment eczema, eczema, auditory meatus is suppurated.The kind clear part of the body cavity above the diaphragm housing the heart and lungs of Rhizoma Coptidis (processed with wine) is burning hot.For conjunctival congestion, aphtha.Prepared RHIZOMA COPTIDIS with rhizoma zingiberis recens juice clearing stomach stomach function regulating preventing or arresting vomiting.Tie mutually damp and hot middle resistance, feeling of fullness vomiting for cold and heat.Cornel Rhizoma Coptidis soothing liver-QI stomach function regulating preventing or arresting vomiting.For incoordination between the liver and stomach, vomiting acid regurgitation.

Radix Berberidis: hardship, cold.Happiness light, resistance to the moon, happiness is loose, rich soil, barren-resistant, strong adaptability.Heat clearing and damp drying, eliminating fire and detoxication.For damp-heat dysentery, jaundice eczema, pharyngalgia conjunctival congestion, Ting discharging ear, carbuncle sore tumefacting virus.Main containing berberine (berberine), palmatine (palmatine palmatine), berbamine (berbamine).Berbamine has remarkable inhibitory action to rat sarcoma W256, share with cyclophosphamide, and effect is added, and both are all strong than alone.Isosinomenine has inhibitory action to ehrlich ascites tumor.Palmatine, jateorhizine, oxyacanthine have inhibitory action to mouse ascites cancerous cell to the picked-up of oxygen.Berbamine has the effect of obvious leukocyte increasing.Rat to caused by cyclophosphamide and canine leucocyte reduce, and lumbar injection berbamine all has obvious antagonism, and platelet is also had to rising trend.In addition, still there are the effects such as resisting pathogenic microbes, blood pressure lowering, function of gallbladder promoting, antiinflammatory.

Rhizoma Imperatae: sweet in the mouth, cold in nature, enter lung, stomach, urinary bladder channel." Bencao Tujing ": " Rhizoma Imperatae, the present has it everywhere.Spring sprouts, and cloth ground is as pin, and the thatch pin of calling between custom, also can eat, very beneficial children's.Xia Sheng spends in vain, and fine so to the autumn, and withered, its root is extremely pure white, also very sweet and refreshing, adopts root June and uses." Compendium of Material Medica: " emesis all blood of being defeated in battle, typhoid fever hiccup, lung-heat dyspnea with rapid respiration, edema, jaundice, alcoholic intoxication." have the effect of cooling blood for hemostasis, clearing away heat and promoting diuresis, being mainly used in lung stomach has haematemesis, the hemoptysis of accumulated heat, and damp invasion of lower energizer pents up the hematuria of bladder, calentura excessive thirst taking fluids profusely, gastropyretic vomiting, the cards such as jaundice due to damp-heat.Rhizoma Imperatae decoct and water logging agent gavage, and normal rabbits is had to diuresis, administration 5-10 days, and diuresis is the most obvious.Rhizoma Imperatae decoct has obvious inhibitory action to Fu Shi and sonne bacillus in vitro, but to will Hayes and the effect of easypro Shigella flexneri nothing.Contraction and the metabolism of the contained Coixol of Rhizoma Imperatae to skeletal muscle has inhibitory action.

Bombyx mori L.: acrid in the mouth, sweet, warm in nature.Compendium of Material Medica: " control and quench one's thirst, crux, and married woman's metrorrhagia, wind syndrome of head, blepharitis marginalis, goes wind dehumidifying." supplement to the Herbal: " and parching to brown, bag is contained infusing drugs in wine, goes the slow all joints of wind unsuccessful, the stupid paralysis of skin, Su Leng in abdomen, cold-blooded blood stasis, waist foot pain is cold." dispeiling pathogenic wind and removing dampness, heat clearing and blood circulation promoting.Dispelling the wind and dampness pathogens, munbness, joint is unsuccessful, the convulsion of sharply vomiting and diarrhoea, muscles and bones is unsuccessful, blood stasis, wind syndrome of head acute conjunctivitis in lumbar and pedal pain, abdomen.This product pungent and sweet flavors can be used for dispersing, can Eradicates wind, warm-dryness syndrome and leading to, and kind dehumidifying relaxing muscles and tendons again, effect relaxes, and can be used for various arthromyodynias." prescriptions worth thousand gold " alone steaming, more presses affected part, and with dispelling the wind and dampness pathogens arthralgia pain, limbs are unsuccessful.Enter taste, the removing dampness of energy stomach function regulating, wetting goes to have loose bowels can stop, muscle arteries and veins can relax.

Fructus Chaenomelis: sour in the mouth, warm in nature, nontoxic; Return liver, spleen channel." modern Practical Chinese medicinal ": " crude fruit liquid, controls gastric indigestion, and is nutriment, is again the agent of stimulating the secretion of milk.Ripe fruit, can sharp defecation, also can control red-white dysentery." " food book on Chinese herbal medicine ": " main promoting the circulation of QI, loose stagnant blood, treats painedly, separates heat stagnation." Fructus Chaenomelis has good relaxing muscles and tendons and activating QI and blood in the collateral effect, and energy removing dampness, by dispelling the wind and dampness pathogens arthralgia pain is commonly used, and particularly key medicine of muscle arteries and veins contracture person.Papaya powder can alleviate liver cell fatty degeneration and the hepatic necrosis that rat skin lower injection carbon tetrachloride causes, prevents that swelling of liver cell and balloon sample from becoming, and can promote hepatocellular reparation, and SGPT is significantly reduced.Multiple intestinal and staphylococcus are had to remarkable inhibitory action, Diplococcus pneumoniae and tubercule bacillus are also had to obvious inhibitory action.Carpaine has the effect of alleviating spasm pain, has obvious therapeutical effect for sural spasm.

Herba Aristolochiae Mollissimae: bitter in the mouth is flat.Return Liver Channel.Wind-damp dispelling, the meridian dredging, pain relieving.For rheumatic arthralgia, numb limbs and tense tendons, muscles and bones contracture, traumatic injury pain.In addition, this product is also available for cancer swollen, can control traumatic hemorrhage etc.

Caulis Sinomenii: bitter, pungent; Return liver, spleen channel.Compendium of Material Medica: " dispelling the wind and dampness pathogens multiple abscess, severe and migratory arthralgia crane knee joint, paralysis pruritus, damage skin ulcer is swollen, enters in yeast for brewing rice wine and uses." " Tianmu Mountains of Zhejiang Province medicine is planted will ": " row water diuresis rushes down part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels blood system damp and hot.Control edema caused by wind, beriberi, Fengshi Guanjie pain, facial hemiparalysis, carbuncle malignant boil." function wind-damp dispelling, the meridian dredging, diuresis.For rheumatic arthralgia, arthroncus, paralysis pruritus.Caulis Sinomenii dispersing wind and cold arthralgia chiefly caused by damp pathogen, can relaxing muscles and tendons to promote blood circulation, the sharp marrow that bonesets, thus syndrome caused by wind pathogen weakness, and the card attached undue importance to one thing to the neglect of the other by force of strength, take for a long time informal dress, make outstanding contributions greatly.

Geranium: bitter, micro-pungent, flat.Return liver, kidney, large intestine channel." the southern regions of the Yunnan Province book on Chinese herbal medicine ": " control meridian hectic fever, dizzy, be afraid of cold, limbs are aching and tired, poor appetite, the virgin infantile malnutrition of male geranium woman, deficient fever do not move back person with it, diuresis, buffalo meat is for drawing." dispel rheumatism, for rheumatic arthralgia.

Semen Lablab Album: sweet light, tepor, flat; Return spleen channel, stomach warp.Spleen invigorating, removing dampness, relieves summer heat.Cure mainly insufficiency of the spleen resulting in production of dampness, anorexia and loose stool, leukorrhagia, heat-damp in summer is vomited and diarrhoea, and excessive thirst is uncomfortable in chest.Semen Lablab Album control heat-damp in summer vomit and diarrhoea, summer heat usually accompanied with dampness, summer heat-damp in summer damaging the spleen and stomach, incoordination between the spleen and stomach, easily causes vomiting and diarrhoea.The invigorating the spleen for eliminating dampness of Semen Lablab Album energy with in.Semen Lablab Album is controlled syndrome of deficiency of spleen qi, and Semen Lablab Album energy QI invigorating is with spleen invigorating.Semen Lablab Album also can be used for the leukorrhagia of insufficiency of the spleen turbid damp bet.

Herba Pogostemonis: pungent, tepor.Return spleen, stomach, lung meridian." pearl sac ": " benefit is defended gas, and stomach reinforcing gas, enters diet, controls again and tells contrary cholera." Li Shizhen (1518-1593 A.D.) says: " Herba Pogostemonis square-stem has in joint empty, and Ye Wei is like Folium Solani Melongenae.Clean Gu, Dong Yuan only use its leaf, need not branch stalk.Moderns branch obstruct with it, and therefore Yin Yeduo is pseudo-ear." removing dampness by means of aromatics, stomach function regulating preventing or arresting vomiting, dispelling summer-heat from superficies of the body.Gastral cavity abdomen painful abdominal mass Min of main retention of dampness in middle-JIAO, inappetence, vomiting, has loose bowels, the headache of the cold and heat of diseases caused by exogenous pathogenic factor heat-damp in summer, hygropyrexia from the beginning of heating body tired, feel sick in breast Min, nasal sinusitis, tinea manus and pedis.Agastache rugosa water decoct has inhibitory action to leptospira in the time that concentration is 15mg/ml; In the time that concentration increases to 31mg/ml, leptospira is had to killing action." Bencao Jingshu ": " hyperactivity of fire caused by deficiency of YIN, the weak nausea of stomach and gastric heat are felt sick, and middle burnt fire is contained thermoae, epidemic febrile disease calentura, the positive bright stomach man domination of pathogen is done swollen, and method is also forbidden.”

Herba Eupatorii: pungent, flat.Return spleen, stomach, lung meridian.Shennong's Herbal: " main dredging water passages, kills diseases due to noxious agents produced by various parasites, eliminating turbid pathogens.Take for a long time QI invigorating, make light of one's life by commiting suicide not old, being proficient in the law of natural movement." " Chinese medicinal herbal ": " deliver damp eliminating, and middleization is turbid.Control summer-heat headache, lossless heating, abdominal distention uncomfortable in chest, sweet greasy in mouthful, halitosis." expelling summer-heat and damp, ward off dirty and in.Be used for experiencing heat-damp in summer, cold and heat headaches, accumulates in moistening, and gastral cavity painful abdominal mass is not hungry, and nausea and vomiting is sweet greasy in mouthful, disappear truly, and turbid damp obstructing in middle-JIAO, gastral cavity painful abdominal mass vomiting and nausea, sweet greasy in mouthful, halitosis, sialism, heat-damp in summer table disease, feeling of fullness in the head is uncomfortable in chest.

Fructus Amomi Rotundus: pungent, temperature; Return lung meridian, spleen channel, stomach warp.Compendium of Material Medica: " control communicable subtropical diseases algid malaria, Sunstroke is told down and is let out dysentery, dysphagia and regurgitation, and feeling of fullness acid regurgitation, phlegm retention is gathered, married woman's malignant histocytosis leukorrhagia, except cold dampness, dissipating depression of QI dispelling the stagnated QI, kills ichthyosacrotoxin." " book on Chinese herbal medicine is original ": " and tonifying the spleen and stomach, mill is stagnant, adjusts very speed of cold scattering gas, and it is the most suitable that weakness can not be drunk trencherman, the alcoholic intoxication of holding concurrently." the function removing dampness painful abdominal mass that disappears, circulation of qi promoting warming middle-JIAO, appetite-stimulating indigestion-relieving.For turbid damp obstructing in middle-JIAO, anorexia, hygropyrexia from the beginning of, uncomfortable in chest not hungry, cold-damp vomiting, chest and abdomen swelling and pain, food stagnation does not disappear.

Herba Abri: sweet, bitter, cool, nontoxic; Enter the heart, lung, liver, stomach, kidney channel." south of the Five Ridges herbal ": " hot and suffocating clearly, soothing liver-QI, and spleen, continuous injured." clearing away heat-damp and promoting diuresis, eliminating stasis to stop pain.Main icterohepatitis, stomachache, rheumatic ostalgia, traumatic injury stasis of blood pain, mastalgia.For normal isolated rabbit ileum, Os Gallus domesticus grass roots decoct can significantly strengthen its shrinkage amplitude, and anesthetized rabbit gavage or intramuscular injection decoct also can make intestinal tube tension force in place improve, and wriggle and slightly strengthen.Os Gallus domesticus grass roots decoct 5g/kg gavages and can significantly strengthen Tolerance of Swimming.The thick Saponin of Herba Abri has remarkable protection effect to hepatic injury due to carbon tetrachloride (CCl4).Herba Abri is the medical herbs spreading among the people, and herbal medicine in ancient times is without record, mainly containing active chemicals such as yearning between lovers alkali, choline.Be applied to more at large at present treatment hepatitis B and fall enzyme.

Radix Aristolochiae: arduous, cold.Enter lung, stomach warp.Tang Materia Medica: " main gathering.All scorchingly hot swollen, snake venom, water rub into mudding it, days three, four; Treat furuncle enlargement effect." " vegetation is side just ": " delivers, except wind.The paralysis of (controlling) rheumatism, waist foot pain, traumatic injury." circulation of qi promoting, removing toxic substances, detumescence.Control chest and abdomen swelling and pain, acute filthy disease, enteritis dysentery, hypertension, hernia, Serpentis stings poison, carbuncle, furuncle, skin pruritus or wet rotten., Radix Aristolochiae (Radix Aristolochiae) crude preparation by using is to various animals, no matter intravenous injection or orally all can cause certain hypotensive effect, and general decoct effect is stronger.To anesthetized animal row vein, injection often causes rapid drawdown form, and intramuscular injection is slower, oral slower.Useful Radix Aristolochiae among the people is controlled stomachache person, uses clinically its crude preparation by using, side effect such as also causing nausea, vomit and be dizzy.The emetic action of Radix Aristolochiae causes mainly due to wherein contained ether soluble acidic composition, and Radix Aristolochiae crude preparation by using has sedation to mice.Chemoreceptor in spleen, the lower limb of refining extractum to rabbit isolated uterine and cat is all without very effect.In the time of heavy dose, there is the effect of some anti-fowl malaria and vitro inhibition dysentery bacterium.

Fevervine: property is flat, sweet in the mouth, micro-hardship." the SHENGCAO property of medicine is standby to be wanted ": " its head is controlled new internal injury, and pot is carnivorous, and tonify deficiency kidney tonifying, except fire is enriched blood; Wash skin ulcer pain relieving, the loose poison of the heat that disappears.Its leaf is beaten rice with confectionery, dysentery relieving." " Zhiwu Mingshi Tukao ": " be wash, removing toxic substances, removes wind, heat clearing away, cold expelling.Apply innominate toxic swelling, and mend muscles and bones." expelling wind and activating blood circulation, analgesic antidotal, dyspepsia and intestinal stasis relieving, dehumidifying detumescence.Dispelling the wind and dampness pathogens pain, diarrhoea dysentery, dirty abdomen pain, deficiency of vital energy edema, dizzy lack of appetite, hepatosplenomegaly, scrofula, acute appendicitis, innominate toxic swelling, traumatic injury.Fevervine total alkaloids lumbar injection can suppress mice voluntary activity, extends pentobarbital sodium length of one's sleep, has certain sedation.Fevervine total alkaloids can suppress myenteron and shrink, and can antagonism myenteron contracture due to acetylcholine.Fevervine decoct has inhibitory action to external staphylococcus aureus and Fu Shigella flexneri, and extractum also has bacteriostasis to staphylococcus aureus and streptococcus pneumoniae.

Semen Arecae: bitter in the mouth, pungent, warm in nature.Return stomach, large intestine channel.There is parasite killing, removing mass, sending down the abnormal ascending QI is capable stagnant, effect that row aquation is wet.Cure mainly rapid digestion of food and relieve oedema or abdominal distension through diuresis or purgation, kill intestinal volt corpse, proglottid of tapeworm; Except dampness, get round by bribery, sharp nine orifices, relieving restlessness, caking in broken abdomen; Also can control that beriberi, edema, chest pain, dysentery, abdominal distention stomachache, defecation are unfavorable, mental disorder dyspnea with rapid respiration, treat pernicious malaria, resist communicable subtropical diseases.Compendium of Material Medica: " semen arecae goes out ridge table, the southern regions of the Yunnan Province, i.e. flat the and puckery person of a kind of enlarged abdomen shape in Semen Arecae, and not like the good ear of the Semen Arecae long taste of point, so-called pig Semen Arecae person is.Cover the different of also local products, moderns very do not distinguish." press Liu Xun " ridge table record " cloud, hand over, wide survivor, Semen Arecae on non-oceangoing ship, all semen arecae also, know in that and exhale as Semen Arecae; delicate and old, adopt and eat it in fact, stay rattan, watt room ash with food to hold up, with the communicable subtropical diseases of dispelling; receive its skin and be used as medicine, black outside skin, Intradermal all muscle silk as Cortex cocois radicis (Cocos nucifera L.)." Yunnan note " cloud again, large every of abdomen Semen Arecae has three, 200, when blue or green, cuts open it, with a slice betel leaf and Pulvis concha Mactrae volume with eat it, subtracts astringent taste.See this and one say, semen arecae and Semen Arecae can be general, but the slightly bad ear of force rate Semen Arecae.

Lignum Dalbergiae Odoriferae: pungent, temperature.Return liver, spleen channel.Promoting flow of QI and blood, pain relieving, hemostasis.For epigastric pain, hypochondriac pain due to stagnation of liverQI, thoracic obstruction twinge, injury from falling down, traumatic hemorrhage.Volatile oil of Lignum Dalbergiae Odoriferae and Aromatic water thereof have anti thrombotic action, and yellow wingceltis have faint anticoagulation, can significantly increase coronary flow, and decreased heart rate, slightly increases heart beating amplitude, does not cause arrhythmia.Lignum Dalbergiae Odoriferae ethanol extraction has convulsion, analgesic activity.Experiment shows that its syndrome of blood stasis animal capable that high molecular dextran is injected to the blood high viscosity syndrome forming is showing whole blood viscosity and reduces, especially taking reduce under high shear rate whole blood viscosity effect as, also can reduce plasma viscosity, but to erythrocyte aggregation without significant impact, Lignum Dalbergiae Odoriferae reduces blood fat in addition, it reduces syndrome of blood stasis animal blood viscosity may be relevant with its effect for reducing fat, and the mechanism of its effect for reducing blood fat is with to suppress HMG CoA-reductase relevant.

Rhizoma Fagopyri Dibotryis: cool in nature, acrid in the mouth, hardship.Energy heat-clearing and toxic substances removing, the eliminating carbuncle of invigorating blood circulation, expelling wind and removing dampness sore, snake bite and insect sting.Main lung abscess, lung-heat cough with asthma, laryngopharynx swelling and pain, dysentery, rheumatism arthromyodynia, traumatic injury, carbuncle cancer.

Semen Mume: how cultivate China various places is maximum with various places on the south the Yangtze river basin.Chemical analysis: Fructus Mume core is containing amygdalin (Amygdalin) approximately 0.5%, Mei Renhan approximately 4.3%.Nature and flavor acid; Flat; Nontoxic.Return through lung; The heart; Liver; Large intestine channel.Function cures mainly the network clearly that drives away summer heat; Liver-benefiting eye-brightening; Clearing away heat and eliminating dampness.Main summer heat cholera; Dysphoria with smothery sensation; Blurring of vision.

Canis familiaris L. ant grass: pulse family Canis familiaris L. ant grass Alysicarpus vaginalis (L.) DC.[A. mummulariaefolius DC.], be used as medicine with herb, root, leaf.Habitats distribution Fujian, Taiwan, Guangxi, Guangdong and Hainan Island.Nature and flavor are sweet, bitter, flat.Function cures mainly promoting blood circulation to remove obstruction in the collateral, and clearing away heat and eliminating dampness is refuted atrophic debility of bones and swollen, removing the necrotic tissue and promoting granulation.Hemiplegia, femur is ached, chronic hepatitis, venom, traumatic injury, fracture, traumatic hemorrhage, skin infection festers and does not close up for a long time.

Fructus Sapindi Mukouossi: nature and flavor hardship, flat, poisonous.1. " herbal classic is met former ": " hardship, flat, nontoxic." 2. " Nanning City's medicine will ": " bitterness, slightly poisonous." function cures mainly heat clearing away, eliminates the phlegm, and removing food stagnancy, parasite killing.Control sore throat and swell and ache, cough with asthma, dyspepsia, leucorrhea, infantile malnutrition, skin ulcer numbness, toxic swelling.For diphtheria disease, seminal vesicle disease, stranguria with turbid discharge frequent micturition.Heat clearing away, eliminates the phlegm, removing food stagnancy, parasite killing.Sore throat swells and ache, cough with asthma, dyspepsia, leucorrhea, infantile malnutrition, skin ulcer tinea, toxic swelling.1. " the SHENGCAO property of medicine is standby to be wanted ": " hemostasis; Simmer food parasite killing, go greasy; Boiling plaster dispels the wind, subsides a swelling, draws out pus by applying a plaster to the affected part." 2. " Guangxi Chinese medicinal herbal ": " ashing is ground into powder and is blown larynx and control celostomia." 3. " Tianmu Mountains of Zhejiang Province medicine is planted will ": " controls various larynx diseases, cold, fever, pertussis, nebulousurine, leucorrhea, infantile malnutrition."

Oleum Camelliae: the fatty oil of chemical analysis (being the glyceride of oleic acid, stearic acid etc.).Nature and flavor are sweet, cool.

1. " agricultural administration book ": " cold in nature." 2. " detailed outline is picked up any lost article from the road ": " sweet in the mouth, cool in nature." 3. " Fujian Chinese herbal medicine ": " is sweet, flat." function cures mainly clearing away heat and eliminating dampness, parasite killing removing toxic substances.Control eruptive disease stomachache, acute ascarid obstructive intestinal obstruction, scabies, burn.1. " agricultural administration book ": " treat skin ulcer scabies, move back damp and hot." 2. " detailed outline is picked up any lost article from the road ": " intestine moistening clearing stomach, parasite killing removing toxic substances." 3. " occupying diet spectrum with trouble ": " moisturizes heat clearing away, endogenous wind stopping, the sharp head."

Herba Urariae crinitae: chemical analysis herb is containing flavonoid glycoside.Nature and flavor " the south of Fujian Province traditional herbal medicine ": " sweet micro-hardship, flat." function cures mainly heat clearing away, removing toxic substances, hemostasis, eliminating carbuncle.Control cough, lung abscess, spits blood, spitting of blood, hematuria, proctoptosis, uterine prolapse, toxic swelling.1. " the south of Fujian Province traditional herbal medicine ": " moisturize antipyretic, eliminating carbuncle removing toxic substances.The hemostasis of " 2. " Guangxi Chinese herbal medicine ": " dissipating blood stasis, clearing and antitussive.Control haematemesis, spitting of blood, hematuria, knife injury is hemorrhage, cough due to lung-heat, uterine prolapse, proctoptosis." 3. LongXi " practical Chinese herbal medicine ": " promoting blood circulation to remove obstruction in the collateral, regulating the flow of Qi and the middle Jiao.Control gastric and duodenal ulcers, pulmonary tuberculosis, leucorrhea, arthritis, infantile malnutrition."

Fructus Amomi: nature and flavor are pungent, temperature.1. " property of medicine opinion ": " bitter in the mouth is pungent." 2. " Haiyao Bencao, Oversea Materia Medica ": " acrid in the mouth is flat, salty." 3. " Kaibao Bencao ": " acrid in the mouth, temperature, nontoxic." 4. " detailed outline ": " is pungent, and temperature is puckery, nontoxic." return through entering spleen, stomach warp.1. Materia Medica of Decoction: " start with, too bright, the sun of yin, yang of foot, meridian of Foot-SHAO YIN." 2. " Bencao Jingshu ": " enters too too bright, the moon of fainting of yin, yang of bright, the moon of fainting of yin, yang, hands of foot." 3. " book on Chinese herbal medicine is new again ": " enters the heart, spleen two warps." function cures mainly in circulation of qi promoting tune, and stomach function regulating, is amusing.Control stomachache painful abdominal mass swollen, anorexia dyspepsia, dysphagic vomiting, diarrhea due to cold pathogen cold-dysentery, pregnant fetal movement.1. " property of medicine opinion ": " main cold air stomachache, only rest diarrhea due to disorder of qi, strain, the digesting and absorbing the essence of foodstuff that disappears, warm taste.The cough of " 2. supplement to the Herbal: " Your Majesty's gas, renal mass, infantile convulsion pathogen." 3. " Japan hanako materia medica ": " controls all gas, cramp caused by acute vomiting and diarrhea, cardiac and abdominal pain.It is depressed stagnant not loose that " 4. Zhang Yuansu: " controls taste." 5. Yang Shiying: " and in, circulation of qi promoting, pain relieving, antiabortive." 6. " book on Chinese herbal medicine covers bamboo fish trap ": " only feels sick, but stomachache." 7. " detailed outline ": " tonifying the lung is amusing, nourishing the stomach kidney tonifying, and reason vigour, dispelling stagnant Qi, cold expelling time swollen painful abdominal mass, dysphagic vomiting, only woman's metrorrhagia, except throat ability to speak superficial heat, changes copper gagger and chokes." 8. " medical center bun is wanted ": " profit kidney, tonifying liver, mends the gate of vitality, and taste, relieving stagnation."

Rhizoma Cyperi: the pungent micro-hardship of nature and flavor is sweet, flat.1. not " not Lu ": " sweet in the mouth, is slightly cold, nontoxic." 2. amplification on Canon of Materia Medica: " bitter in the mouth." 3. " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " slightly warm in nature, acrid in the mouth." 4. " detailed outline ": " gas is flat, and the micro-hardship of acrid in the mouth is micro-sweet." return through entering liver, tri-jiao channel.1. " detailed outline ": " brothers are silent cloudy, the few sun of hands, and the row 12 of holding concurrently is through, eight arteries and veins edema caused by disorder of QI." 2. " Thunder God is concocted property of medicine solution ": " enters lung, liver, spleen, stomach four warps." function cures mainly the resolving depression of regulating the flow of vital energy, pain relieving regulating menstruation.Treating the liver discomfort in the stomach, depression of QI, breast abdomen distending pain over the hypochondrium, phlegm retention feeling of fullness, menoxenia, bleeding not during menses.(1) resolving depression of regulating the flow of vital energy: for the breast side of body and the stomach abdominal distention and pain of depression of liver-QI.Join Radix Bupleuri, Pericarpium Citri Reticulatae Viride is controlled chest and hypochondrium.Join Rhizoma Alpiniae Officinarum (name Liang Fu Wan) and control cold syndrome of the stomach pain.(2) menstruction regulating and pain relieving: for menoxenia, the lower abdominal distention pain of depression of liver-QI.Join Folium Artemisiae Argyi and control the menalgia of QI stagnated by cold.1. not " not Lu ": " mainly fill fur except feverish sensation in the chest, take for a long time sharp people, QI invigorating, long man." 2. Tang Materia Medica: " large therapeutic method to keep the adverse QI flowing downwards, except breast heat in the abdomen." 3. " medicine origin ": " fast gas." 4. Li Gao: " controls all gas, and cholera vomiting and diarrhoea stomachache, kidney qi, and bladder is cold, removing stagnancy of indigested food and making QI downward." 5. Materia Medica of Decoction: " controls metrorrhagia." 6. " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " adjusts the gas in blood, dissipating depression of QI, and alleviating distention in middle-JIAO, helps digestion, and preventing or arresting vomiting is told.The cold epidemic disease of " 7. " detailed outline ": " loose seasonal epidemic pathogens, sharp three warmers, separate six kinds of stagnation-syndromes, and the diet that disappears gathers, phlegm retention feeling of fullness, edema of dorsum of the foot, abdominal distention, beriberi, only trusted subordinate, limbs, head, order, tooth, all pains of ear, ulcer sores, spits blood, hematochezia, hematuria, married woman's bleeding not during menses, month time is uncomfortable, tire all kinds of diseases and ailments in front puerperal."

Rhizoma valerianae latifoliae: nature and flavor are " detailed outline " 1.: " pungent, temperature, nontoxic." 2. " Kweiyang medicinal herbs among the people ": " are arduous, and temperature is nontoxic." return through 1. " Traditional Chinese Medicine in Sichuan will ": " enters lung, stomach two warps." 2. " Guangxi Chinese medicinal herbal ": " enters spleen, stomach two warps." function cures mainly circulation of qi promoting, and cold expelling is invigorated blood circulation, regulating menstruation.Control sun stroke abdominal distention, vomiting is had loose bowels, lung qi edema, anemofrigid cold, menoxenia, the cough of consumptive disease wound.1. " detailed outline ": " ward off pestilence, attacked by pestiferous factors." 2. " Guizhou side's medicine among the people collection ": " calmness, pleasant, help digestion.Control abdominal distention and pain, peratodynia.Control again infantile convulsion." 3. " Kweiyang medicinal herbs among the people ": " control flatulence, sun stroke, and stomachache, sealing rushes down." 4. " Guangxi Chinese medicinal herbal ": " dehumidifying cold expelling, controls beriberi edema, taste dyspepsia, external application furuncle." 5. " Shaanxi Chinese herbal medicine ": " invigorates blood circulation, regulating menstruation.Control headache, arthralgia, menoxenia, traumatic injury, furuncle." 6. " Yunnan Chinese herbal medicine ": " controls dyspepsia, infantile cough, infantile malnutrition, influenza, malaria."

Herba potamogetonis distincti's root: ecological environment: be 1. born in paddy field or pool.2. be born in hydrostatic pond.Resource distribution: be 1. distributed in national most areas.2. be distributed in northeast and Jiangsu, Zhejiang, Jiangxi, Fujian, Taiwan, Henan, Hubei, Hunan, Sichuan.Function cures mainly regulating the flow of Qi and the middle Jiao; Hemostasis.Main flatulence due to stagnation of QI stomachache; Lumbago; Bleeding hemorrhoids.

Radix Angelicae Pubescentis: nature and flavor are arduous, temperature.1. " herbal classic ": " hardship, flat." 2. " not Lu ": " is sweet, and tepor is nontoxic." 3. " property of medicine opinion ": " bitter in the mouth is pungent." 4. " book on Chinese herbal medicine is just ": " bitter in the mouth, slightly cool in nature." return through entering kidney, urinary bladder channel.1. " pearl sac ": " kidney meridian, heart channel of Hand-Shaoyin." 2. " Thunder God is concocted property of medicine solution ": " enters lung, kidney two warps." 3. " explaining abstruseness of the canon of materia medica ": " hands, the sufficient sun, few cloudy, the moon of fainting of foot." 4. " medicine justice ": " enters the heart, liver, kidney, bladder four warps." function cures mainly and dispels the wind, and victory is wet, cold expelling, pain relieving.Control anemofrigid-damp arthralgia, soreness of waist and knee joint, trick spasm and pain, chronic tracheitis, headache, toothache.1. " herbal classic ": " the cold institute of main air is hit, incised wound pain relieving, renal mass ， Xian Chi, woman's hernia abdominal mass." 2. " not Lu ": " controls all wind, and hundred arthralgia wind are without for a long time new person." 3. " property of medicine opinion ": " control in all rheumatism cold, the dyspnea gas of running quickly, musculus cutaneus hardship is itched, brothers' spasm and pain, strain, main air poison toothache." 4. " medicine origin ": " cures mainly the secret cloud of wanting: energy dampness, and hardship is dazzle the eyes fortune, and non-this can not remove." 5. Zhang Yuansu: " the carbuncle deteriorated blood that falls apart." 6. Li Gao: " controls anemofrigid-damp arthralgia, aches meciless, all wind trembling and dizziness, and head term difficulty is stretched." 7. Wang Haogu: " goes ailment said due to cold or exposure between kidney, searches liver-wind, and eliminating pathogen in the liver gas is controlled stiffness of the nape pain along the spinal column." 8. " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " diaphoresis, controls two sides of body, the cold pain of face." 9. " explaining abstruseness of the canon of materia medica ": " controls aphonia in silence, and brothers are not with, facial hemiparalysis, and conjunctival congestion skin is itched." 10. " book on Chinese herbal medicine is just ": " reason part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels rheumatism, two pain in foot numbness, pruritus due to damp pathogen contracture." " modern Practical Chinese medicinal ": " diaphoresis, diuresis, edema disappears."

Exocarpium Citri Grandis: chemical analysis fruit is containing naringin, naringin unit; Peel is containing citral, geraniol, linalool, phosphorus Methyl anthranilate etc.Decontamination is chosen in the process of preparing Chinese medicine, outwash, and used time thumb is broken.Nature and flavor toil, temperature.1. " detailed outline is picked up any lost article from the road ": " bitter in the mouth is pungent." 2. " south of the Five Ridges gather medicinal herbs record ": " bitter in the mouth is pungent, warm in nature flat, nontoxic." function cures mainly and reduces phlegm, and regulates the flow of vital energy, and stomach invigorating, helps digestion.Control that expectorant is stagnant in the heart, cough and asthma, vomiting singultus, eating accumulation." detailed outline is picked up any lost article from the road ": " control phlegm syndrome, greasy, the paddy food stagnation that disappears, relieving alcoholic intoxication, alleviating distention in middle-JIAO, separates Eriocheir sinensis poison."

Liquor Fructus Fortunellae Distillata: habitats distribution ecological environment: mostly be cultivation.Resource distribution: 1. there is cultivation in Zhejiang, Jiangxi, Fujian, Taiwan, Hubei, Guangdong, Hainan, Guangxi, Sichuan.2. the North Guangdong common cultivation in area.3. be distributed in Anhui, Zhejiang, Fujian, Taiwan, Guangdong, Guizhou.Nature and flavor are sweet; Pungent; Micro-hardship; Temperature function cures mainly liver-smoothing, qi-regulating; Reduce phlegm and in.Main energy-stagnation stomachache; Vomiting due to retention of food; Cough with copious phlegm.

Herba Gnaphalii uliginosi: nature and flavor are " Chinese herbal medicine handbook is commonly used in northeast " 1.: " sweet, flat." 2. " plateau Chinese herbal treatment handbook ": " is sweet, is slightly cold." returning through " plateau Chinese herbal treatment handbook ": " enters lung, intestine and small intestine warp." function cures mainly relieving cough and resolving phlegm, damp eliminating, and in tune, blood pressure lowering, the skin ulcer that disappears is swollen.Control cough and asthma, bones and muscles pain, hygropyretic dysentery, gastric ulcer, hypertension, carbuncle pyogenic infections from tumour or sore.1. " northeast medicine is planted will ": " relieving cough and resolving phlegm.Control asthma and bronchitis, gastric ulcer, hypertension, burn, abscess.QI invigorating in " 2. " Chinese herbal medicine handbook is commonly used in northeast ": " tune, relieving cough and resolving phlegm." 3. " the conventional Chinese herbal medicine handbook in the north ": " controls dysmenorrhea." 4. " plateau Chinese herbal treatment handbook ": " controls laryngopharynx swelling and pain, and tuberculosis pneumonia is red white under dysentery, carbuncle pyogenic infections from tumour or sore."

In described Chinese medicine composition, the ratio of weight and number of each raw medicinal material is: Rhizoma Phragmitis 10-30 weight portion, Radix Scutellariae 12-25 weight portion, Rhizoma Coptidis 10-20 weight portion, Radix Berberidis 4-9 weight portion, Rhizoma Imperatae 10-20 weight portion, Bombyx mori L. 13-28 weight portion, Fructus Chaenomelis 10-28 weight portion, Herba Aristolochiae Mollissimae 10-25 weight portion, Caulis Sinomenii 10-30 weight portion, geranium 10-27 weight portion, Semen Lablab Album 15-26 weight portion, Herba Pogostemonis 6-10 weight portion, Herba Eupatorii 10-20 weight portion, Fructus Amomi Rotundus 15-30 weight portion, Herba Abri 10-24 weight portion, Radix Aristolochiae 7-10 weight portion, fevervine 12-24 weight portion, Semen Arecae 10-20 weight portion, Lignum Dalbergiae Odoriferae 6-10 weight portion, Rhizoma Fagopyri Dibotryis 14-29 weight portion, Semen Mume 10-20 weight portion, Canis familiaris L. ant grass 15-30 weight portion, Fructus Sapindi Mukouossi 12-26 weight portion, Oleum Camelliae 10-20 weight portion, Herba Urariae crinitae 15-26 weight portion, Fructus Amomi 10-30 weight portion, Rhizoma Cyperi 14-25 weight portion, Rhizoma valerianae latifoliae 15-27 weight portion, the root 10-25 of Herba potamogetonis distincti weight portion, Radix Angelicae Pubescentis 10-30 weight portion, Exocarpium Citri Grandis 10-26 weight portion, Liquor Fructus Fortunellae Distillata 14-30 weight portion and Herba Gnaphalii uliginosi 10-20 weight portion.

In described Chinese medicine composition, the ratio of weight and number of each raw medicinal material is: Rhizoma Phragmitis 20-30 weight portion, Radix Scutellariae 12-20 weight portion, Rhizoma Coptidis 15-20 weight portion, Radix Berberidis 4-5 weight portion, Rhizoma Imperatae 15-20 weight portion, Bombyx mori L. 23-28 weight portion, Fructus Chaenomelis 20-28 weight portion, Herba Aristolochiae Mollissimae 15-25 weight portion, Caulis Sinomenii 20-30 weight portion, geranium 15-27 weight portion, Semen Lablab Album 15-20 weight portion, Herba Pogostemonis 6-7 weight portion, Herba Eupatorii 15-20 weight portion, Fructus Amomi Rotundus 25-30 weight portion, Herba Abri 10-20 weight portion, Radix Aristolochiae 7-8 weight portion, fevervine 15-24 weight portion, Semen Arecae 15-20 weight portion, Lignum Dalbergiae Odoriferae 6-8 weight portion, Rhizoma Fagopyri Dibotryis 14-20 weight portion, Semen Mume 15-20 weight portion, Canis familiaris L. ant grass 25-30 weight portion, Fructus Sapindi Mukouossi 22-26 weight portion, Oleum Camelliae 15-20 weight portion, Herba Urariae crinitae 15-20 weight portion, Fructus Amomi 20-30 weight portion, Rhizoma Cyperi 14-20 weight portion, Rhizoma valerianae latifoliae 15-20 weight portion, the root 15-25 of Herba potamogetonis distincti weight portion, Radix Angelicae Pubescentis 20-30 weight portion, Exocarpium Citri Grandis 15-26 weight portion, Liquor Fructus Fortunellae Distillata 24-30 weight portion and Herba Gnaphalii uliginosi 15-20 weight portion.

In described Chinese medicine composition, the ratio of weight and number of each raw medicinal material is: Rhizoma Phragmitis 15 weight portions, Radix Scutellariae 25 weight portions, Rhizoma Coptidis 10 weight portions, Radix Berberidis 9 weight portions, Rhizoma Imperatae 12 weight portions, Bombyx mori L. 18 weight portions, Fructus Chaenomelis 18 weight portions, Herba Aristolochiae Mollissimae 14 weight portions, Caulis Sinomenii 15 weight portions, geranium 14 weight portions, Semen Lablab Album 24 weight portions, Herba Pogostemonis 8 weight portions, Herba Eupatorii 14 weight portions, Fructus Amomi Rotundus 20 weight portions, Herba Abri 24 weight portions, Radix Aristolochiae 9 weight portions, fevervine 14 weight portions, Semen Arecae 14 weight portions, Lignum Dalbergiae Odoriferae 9 weight portions, Rhizoma Fagopyri Dibotryis 29 weight portions, Semen Mume 14 weight portions, Canis familiaris L. ant grass 20 weight portions, Fructus Sapindi Mukouossi 16 weight portions, Oleum Camelliae 14 weight portions, Herba Urariae crinitae 26 weight portions, Fructus Amomi 18 weight portions, Rhizoma Cyperi 25 weight portions, Rhizoma valerianae latifoliae 25 weight portions, Herba potamogetonis distincti's root 14 weight portions, Radix Angelicae Pubescentis 17 weight portions, Exocarpium Citri Grandis 14 weight portions, Liquor Fructus Fortunellae Distillata 20 weight portions and Herba Gnaphalii uliginosi 14 weight portions.

In described Chinese medicine composition, the ratio of weight and number of each raw medicinal material is: Rhizoma Phragmitis 25 weight portions, Radix Scutellariae 18 weight portions, Rhizoma Coptidis 20 weight portions, Radix Berberidis 5 weight portions, Rhizoma Imperatae 15 weight portions, Bombyx mori L. 23 weight portions, Fructus Chaenomelis 25 weight portions, Herba Aristolochiae Mollissimae 20 weight portions, Caulis Sinomenii 25 weight portions, geranium 17 weight portions, Semen Lablab Album 18 weight portions, Herba Pogostemonis 6 weight portions, Herba Eupatorii 20 weight portions, Fructus Amomi Rotundus 25 weight portions, Herba Abri 15 weight portions, Radix Aristolochiae 7 weight portions, fevervine 20 weight portions, Semen Arecae 18 weight portions, Lignum Dalbergiae Odoriferae 6 weight portions, Rhizoma Fagopyri Dibotryis 18 weight portions, Semen Mume 20 weight portions, Canis familiaris L. ant grass 28 weight portions, Fructus Sapindi Mukouossi 26 weight portions, Oleum Camelliae 20 weight portions, Herba Urariae crinitae 18 weight portions, Fructus Amomi 27 weight portions, Rhizoma Cyperi 18 weight portions, Rhizoma valerianae latifoliae 18 weight portions, Herba potamogetonis distincti's root 25 weight portions, Radix Angelicae Pubescentis 26 weight portions, Exocarpium Citri Grandis 26 weight portions, Liquor Fructus Fortunellae Distillata 27 weight portions and Herba Gnaphalii uliginosi 18 weight portions.

In order to solve the problems of the technologies described above, the present invention also provides a kind of preparation method of described Chinese medicine composition, and when the dosage form of described Chinese medicine composition is oral solutions, its preparation method is:

The first step, Rhizoma Phragmitis, Radix Scutellariae, Rhizoma Coptidis, Radix Berberidis and Rhizoma Imperatae are mixed, the alcohol reflux that to add with respect to 2 times～4 times, mixture amount determining alcohols be 75%～80% 2 times～4 times, each 2 hours～3 hours, filter, filtrate merges, and reclaims ethanol, be concentrated into the mastic that 70 DEG C of relative densities are 1.20～1.22, for subsequent use;

Second step, is mixed in proportion described residue raw medicinal material, adds with respect to 3～5 times of water gagings of mixture, boils 2～4 hours, filters, and is concentrated into the mastic that 70 DEG C of relative densities are 1.21～1.24;

The 3rd step, the described mastic that the first step, second step are obtained mixes, and 55 DEG C～65 DEG C reduced vacuum are dry, and powder gets dry extract;

The 4th step, will the 3rd add ethanol in the described dried cream powder that obtains of step, obtain containing alcohol mastic, and described is 75%～80% containing alcohol mastic containing alcohol amount; Carry out successively cold preservation processing, precipitation process, filtration treatment, recovery Ethanol Treatment by described containing alcohol mastic, obtain dealcoholysis mastic, wherein, the cold preservation processing time is 30～40 hours;

The 5th step, will add cane sugar powder, active carbon in described dealcoholysis mastic, carries out successively heat treated, filtration treatment, dilution process, obtains semi-finished product; The weight ratio of described dealcoholysis mastic and described cane sugar powder is 1: 0.12～0.3; The weight ratio of described dealcoholysis mastic and described active carbon is 1: 0.001～0.002; The time of described heat treated is 30～40 minutes, and temperature is 100 DEG C～110 DEG C;

The 6th step, the more described semi-finished product of the 5th step acquisition are carried out to filtration treatment, embedding processing, sterilization treatment successively, obtain described Chinese medicine preparation oral liquid finished product.

When the dosage form of described Chinese medicine composition is syrup, its preparation method is:

The first step, Rhizoma Phragmitis, Radix Scutellariae, Rhizoma Coptidis, Radix Berberidis, Rhizoma Imperatae, Bombyx mori L., Fructus Chaenomelis, Herba Aristolochiae Mollissimae, Caulis Sinomenii, geranium, Semen Lablab Album and Herba Pogostemonis are mixed in described ratio, use the dissolve with ethanol with respect to the determining alcohol 80%～90% of 2～4 times of the mixture quality obtaining, reflux was extracted after 2～4 hours, filter, obtain the first filtrate; Filtering residue is used to the dissolve with ethanol with respect to the determining alcohol 80%～90% of 1～2 times of the mixture quality obtaining again, and reflux was extracted after 1～2 hour, filtered, and obtained the second filtrate; Merge the first filtrate and the second filtrate, decompression recycling ethanol to be concentrated into liquor strength be 0.7～0.9g crude drug/mL, utilize the macroporous adsorptive resins eluting that volume is 5L, first use deionized water or the distilled water eluting of 6 times of resin column volumes, be 90%～95% ethanol elution with the determining alcohol of 3 times of resin column volumes again, collect ethanol elution, concentrating under reduced pressure is removed ethanol, is dried and is ground into powder;

Second step, Herba Eupatorii, Fructus Amomi Rotundus, Herba Abri and Radix Aristolochiae are mixed in described ratio, add with respect to obtain mixture quality the determining alcohol 85%～90% of 2～4 times alcohol heating reflux extract 1～2 time, extracting solution merges, with the centrifugal remove impurity of tube centrifuge, the mastic that when extracting solution after remove impurity is evaporated to 60 DEG C under the condition of 65 DEG C～70 DEG C, relative density is 1.22～1.25, is dried to powder by the mastic after concentrated with spray dryer;

The 3rd step, mixes surplus stock medical material in described ratio, add the water dissolution of 2～4 times with respect to the mixture quality obtaining, and heating decocts 2～3 hours, filters; Filtering residue is used to the water dissolution of 1～2 times with respect to the mixture quality obtaining again, and heating decocts 1～2 hour, filters; Merge the filtrate of twice, concentrating under reduced pressure is removed moisture, is dried and is ground into powder;

The 4th step, the powder that the first step, second step and the 3rd step are obtained mixes, add the water dissolution with respect to 1.5～3 times of mixture qualities, with 50% sodium hydroxide solution adjusting pH value to 7.0, stir evenly cold preservation 48 hours～72 hours under 10 DEG C～14 DEG C conditions, filter, filtrate adds the sucrose with respect to 0.3～0.4 times of the mixture quality obtaining, and stirs and dissolves, and regulates pH value to 7.0, add water appropriate, stir, static 12～20 hours, filter, fill, sterilizing, obtains syrup, and the crude drug concentration in described syrup is 1.2 g/mL～1.5g/mL.

Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure of reaching technique effect can fully understand and implement according to this.

Embodiment 1 oral solutions

Rhizoma Phragmitis 15 weight portions, Radix Scutellariae 25 weight portions, Rhizoma Coptidis 10 weight portions, Radix Berberidis 9 weight portions, Rhizoma Imperatae 12 weight portions, Bombyx mori L. 18 weight portions, Fructus Chaenomelis 18 weight portions, Herba Aristolochiae Mollissimae 14 weight portions, Caulis Sinomenii 15 weight portions, geranium 14 weight portions, Semen Lablab Album 24 weight portions, Herba Pogostemonis 8 weight portions, Herba Eupatorii 14 weight portions, Fructus Amomi Rotundus 20 weight portions, Herba Abri 24 weight portions, Radix Aristolochiae 9 weight portions, fevervine 14 weight portions, Semen Arecae 14 weight portions, Lignum Dalbergiae Odoriferae 9 weight portions, Rhizoma Fagopyri Dibotryis 29 weight portions, Semen Mume 14 weight portions, Canis familiaris L. ant grass 20 weight portions, Fructus Sapindi Mukouossi 16 weight portions, Oleum Camelliae 14 weight portions, Herba Urariae crinitae 26 weight portions, Fructus Amomi 18 weight portions, Rhizoma Cyperi 25 weight portions, Rhizoma valerianae latifoliae 25 weight portions, Herba potamogetonis distincti's root 14 weight portions, Radix Angelicae Pubescentis 17 weight portions, Exocarpium Citri Grandis 14 weight portions, Liquor Fructus Fortunellae Distillata 20 weight portions and Herba Gnaphalii uliginosi 14 weight portions.

Its preparation method comprises the following steps:

The first step, mixes Rhizoma Phragmitis, Radix Scutellariae, Rhizoma Coptidis, Radix Berberidis and Rhizoma Imperatae, the alcohol reflux that to add with respect to 2 times of amount determining alcohols of mixture be 75% 2 times, each 3 hours, to filter, filtrate merges, reclaim ethanol, be concentrated into the mastic that 70 DEG C of relative densities are 1.22, for subsequent use;

Second step, is mixed in proportion described residue raw medicinal material, adds with respect to 3 times of water gagings of mixture, boils 2 hours, filters, and is concentrated into the mastic that 70 DEG C of relative densities are 1.21;

The 3rd step, the described mastic that the first step, second step are obtained mixes, and 65 DEG C of reduced vacuum are dry, and powder gets dry extract;

The 4th step, will the 3rd add ethanol in the described dried cream powder that obtains of step, obtain containing alcohol mastic, and described is 75% containing alcohol mastic containing alcohol amount; Carry out successively cold preservation processing, precipitation process, filtration treatment, recovery Ethanol Treatment by described containing alcohol mastic, obtain dealcoholysis mastic, wherein, the cold preservation processing time is 40 hours;

The 5th step, will add cane sugar powder, active carbon in described dealcoholysis mastic, carries out successively heat treated, filtration treatment, dilution process, obtains semi-finished product; The weight ratio of described dealcoholysis mastic and described cane sugar powder is 1: 0.12; The weight ratio of described dealcoholysis mastic and described active carbon is 1: 0.001; The time of described heat treated is 40 minutes, and temperature is 110 DEG C;

The 6th step, the more described semi-finished product of the 5th step acquisition are carried out to filtration treatment, embedding processing, sterilization treatment successively, obtain described Chinese medicine preparation oral liquid finished product.

Embodiment 2 syrups

Rhizoma Phragmitis 25 weight portions, Radix Scutellariae 18 weight portions, Rhizoma Coptidis 20 weight portions, Radix Berberidis 5 weight portions, Rhizoma Imperatae 15 weight portions, Bombyx mori L. 23 weight portions, Fructus Chaenomelis 25 weight portions, Herba Aristolochiae Mollissimae 20 weight portions, Caulis Sinomenii 25 weight portions, geranium 17 weight portions, Semen Lablab Album 18 weight portions, Herba Pogostemonis 6 weight portions, Herba Eupatorii 20 weight portions, Fructus Amomi Rotundus 25 weight portions, Herba Abri 15 weight portions, Radix Aristolochiae 7 weight portions, fevervine 20 weight portions, Semen Arecae 18 weight portions, Lignum Dalbergiae Odoriferae 6 weight portions, Rhizoma Fagopyri Dibotryis 18 weight portions, Semen Mume 20 weight portions, Canis familiaris L. ant grass 28 weight portions, Fructus Sapindi Mukouossi 26 weight portions, Oleum Camelliae 20 weight portions, Herba Urariae crinitae 18 weight portions, Fructus Amomi 27 weight portions, Rhizoma Cyperi 18 weight portions, Rhizoma valerianae latifoliae 18 weight portions, Herba potamogetonis distincti's root 25 weight portions, Radix Angelicae Pubescentis 26 weight portions, Exocarpium Citri Grandis 26 weight portions, Liquor Fructus Fortunellae Distillata 27 weight portions and Herba Gnaphalii uliginosi 18 weight portions.

Its preparation method comprises the following steps:

The first step, Rhizoma Phragmitis, Radix Scutellariae, Rhizoma Coptidis, Radix Berberidis, Rhizoma Imperatae, Bombyx mori L., Fructus Chaenomelis, Herba Aristolochiae Mollissimae, Caulis Sinomenii, geranium, Semen Lablab Album and Herba Pogostemonis are mixed in described ratio, use the dissolve with ethanol with respect to the determining alcohol 90% of 2 times of the mixture quality obtaining, reflux was extracted after 2 hours, filter, obtain the first filtrate; Filtering residue is used to the dissolve with ethanol with respect to the determining alcohol 80% of 2 times of the mixture quality obtaining again, and reflux was extracted after 2 hours, filtered, and obtained the second filtrate; Merge the first filtrate and the second filtrate, decompression recycling ethanol to be concentrated into liquor strength be 0.9g crude drug/mL, utilize the macroporous adsorptive resins eluting that volume is 5L, first use deionized water or the distilled water eluting of 6 times of resin column volumes, use again determining alcohol 95% ethanol elution of 3 times of resin column volumes, collect ethanol elution, concentrating under reduced pressure is removed ethanol, is dried and is ground into powder;

Second step, Herba Eupatorii, Fructus Amomi Rotundus, Herba Abri and Radix Aristolochiae are mixed in described ratio, add with respect to obtain mixture quality the determining alcohol 85% of 2 times alcohol heating reflux extract 2 times, extracting solution merges, with the centrifugal remove impurity of tube centrifuge, the mastic that when extracting solution after remove impurity is evaporated to 60 DEG C under the condition of 70 DEG C, relative density is 1.25, is dried to powder by the mastic after concentrated with spray dryer;

The 3rd step, mixes surplus stock medical material in described ratio, add the water dissolution of 2 times with respect to the mixture quality obtaining, and heating decocts 3 hours, filters; Filtering residue is used to the water dissolution of 2 times with respect to the mixture quality obtaining again, and heating decocts 2 hours, filters; Merge the filtrate of twice, concentrating under reduced pressure is removed moisture, is dried and is ground into powder;

The 4th step, the powder that the first step, second step and the 3rd step are obtained mixes, and adds the water dissolution with respect to 3 times of mixture qualities, with 50% sodium hydroxide solution adjusting pH value to 7.0, stir evenly cold preservation 72 hours under 14 DEG C of conditions, filter, filtrate adds the sucrose with respect to 0.4 times of the mixture quality obtaining, and stirs and dissolves, regulate pH value to 7.0, add water appropriate, stir, static 12 hours, filter fill, sterilizing, obtains syrup, and the crude drug concentration in described syrup is 1.2 g/mL.

Embodiment 3 tablets

Rhizoma Phragmitis 15g, Radix Scutellariae 25g, Rhizoma Coptidis 10g, Radix Berberidis 9g, Rhizoma Imperatae 12g, Bombyx mori L. 18g, Fructus Chaenomelis 18g, Herba Aristolochiae Mollissimae 14g, Caulis Sinomenii 15g, geranium 14g, Semen Lablab Album 24g, Herba Pogostemonis 8g, Herba Eupatorii 14g, Fructus Amomi Rotundus 20g, Herba Abri 24g, Radix Aristolochiae 9g, fevervine 14g, Semen Arecae 14g, Lignum Dalbergiae Odoriferae 9g, Rhizoma Fagopyri Dibotryis 29g, Semen Mume 14g, Canis familiaris L. ant grass 20g, Fructus Sapindi Mukouossi 16g, Oleum Camelliae 14g, Herba Urariae crinitae 26g, Fructus Amomi 18g, Rhizoma Cyperi 25g, Rhizoma valerianae latifoliae 25g, the root 14g of Herba potamogetonis distincti, Radix Angelicae Pubescentis 17g, Exocarpium Citri Grandis 14g, Liquor Fructus Fortunellae Distillata 20g and Herba Gnaphalii uliginosi 14g.

Its preparation method comprises the following steps;

The first step, is mixed in proportion each described Chinese medicine raw medicinal material, the ethanol that to add with respect to the determining alcohol of 4 times of mixture qualities be 85%, and reflux 3 hours, extracts, and filters and obtains the first extracting solution; The ethanol that it is 85% that the medicinal residues that filtration obtains add with respect to the determining alcohol of 2 times of described medicinal residues quality again, reflux 1 hour, extracts, and filters and obtains the second extracting solution; The first extracting solution and the second extracting solution are merged, and concentrating under reduced pressure is removed alcohol solvent, dry, obtains and gets dry extract;

Second step, the dry cream that the first step is obtained is placed in super micron mill to be pulverized 2 hours, pulverizes, and sieves, and obtains 400 object micropowders;

The 3rd step, the micropowders that second step is obtained, adds with respect to the microcrystalline Cellulose of 0.3 times of its quality, 0.05 times of lactose, the starch of 0.1 times, sieves, mix homogeneously, granulates, dry, adds with respect to 0.005 times of magnesium stearate of micropowders quality, granulate, tabletting, makes.

Toxicity test

1. acute toxicity test

40 of application NIH mices, SPF level, male and female half and half, body weight 18～22g, tests.Mice is divided into two groups at random, and 20 every group, i.e. matched group and administration group, fasting 12 hours before experiment; (concentration is 6.5g crude drug/ml to oral solutions prepared by embodiments of the invention 1, maximum concentration) gavage, gavage volume is that 5ml/kg(is that single-dose dosage is 32.5 crude drugs/kg), matched group gives equivalent normal saline, administration in one day 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record mice toxic reaction and death toll.Experimental result shows: with matched group comparison, after administration, mice has no notable difference, experiment Continuous Observation 14 days, and mice overall health of patients, diet, drinking-water, body weight gain are all normal.Mice oral administration gavage oral solutions LD50>32.5 of the present invention crude drug/kg, every day, maximum dosage-feeding was 65.0g crude drug/kg/ day.Chinese medicine clinical application amount of the present invention is 4.4g crude drug/day/people, becomes body weight for humans in 60KG, and average dosage is 0.073g crude drug/kg/ day.By weighing machine: the dosis tolerata of mice (average weight is taking 20g) oral administration gavage Chinese medicine of the present invention is 890 times of quantity.Therefore Chinese medicine composition acute toxicity of the present invention is low, clinical drug safety.

2. cumulative toxicity test

Test method: select 20 healthy mices, female, male each 10, taking the syrup of the embodiment of the present invention 2 as object, it is first phase that dosage designs every 5 days, each issue dosage is respectively 0.10LD50,0.15LD50,0.20LD50,0.25LD50,0.30LD50, and the LD 50 female, male mice of this sample is 6000m part/k part BW (five dosage be 600,900,1200,1500,1800m part/k part BW).Within every 5 days, weigh once, adjust dosage, by 0.1ml/10 part BW per os gavage.After 20 days, animal occurs without death condition, off-test, and by ascending-dose, to tested material after 20 days, female, buck all occurs without death condition.Illustrate, Chinese medicine composition of the present invention does not have intoxicating.

 

Clinical trial

Data and method

During choosing in May, 2011-2012 year May, the patient of the spleen and stomach damp-heat type chronic gastritis that my institute receives amounts to 200 examples, course of disease 1-3 not etc., in patient, male patient is 110 examples, female patient is 90 examples, and wherein age distribution is 20-40 50 people in year, 60 people in 40-55 year, 55 years old 90 above people, all meet the diagnostic criteria of spleen and stomach damp-heat type chronic gastritis.This 200 routine patient is carried out to random packet, be divided into 100 examples for treatment by Chinese herbs group, 100 examples are tested for other drug matched group.Two groups of patients, at physical data comparing difference not statistically significants such as sex, age, the state of an illness, have comparability.

Diagnostic criteria

Primary symptom: the 1. scorching hot distending pain of gastral cavilty.2. bitter to the taste, halitosis.3. yellowish urine.4. gastral cavity abdomen painful abdominal mass is vexed, thirst but no desire to drink.

Inferior disease: 1. acute, the Active inflammation of gastric mucosa, congested obviously rotten to the corn.2. picture of the tongue pulse condition: red tongue, limit point is dark red, and yellow fur is thick or greasy, rolling pulse, tense pulse.

Pattern of syndrome is determined: 1. possess 2 of primary symptoms, tongue arteries and veins meets substantially.2. possess 1 of primary symptom and inferior disease, tongue arteries and veins meets substantially.Possessing in two one can determine.

Therapeutic Method:

Treatment by Chinese herbs group: this is organized 100 routine patients and uses the oral solutions of embodiments of the invention 1 to treat.3 times on the one oral medications, take for 2 ~ 3 hours after meal, within every 7 days, are 1 course for the treatment of, and treatment is carried out 3 courses for the treatment of.

Western medicine group: this is organized 100 routine patients and uses Compound Allantoin sheet treatment: one time 2 ~ 3,3 times on the one, within 2 ~ 3 hours after meal, take, within every 7 days, be 1 course for the treatment of, treat 3 courses for the treatment of.

Efficacy evaluation

1. Short Term Clinical is cured: comprise following all indexs: 1. clinical cardinal symptom disappears, and inferior disease disappears or substantially disappears.2. gastroscope check Active inflammation disappears, and chronic inflammatory disease is pass on well slightly.3. biopsy proved by pathology gastroscope finding, body of gland atrophy, intestinalization life and dysplasia recover normal or disappear.4. gastric acid recovers normally substantially, and bile reflux disappears.

2. effective: 1. clinical cardinal symptom disappears, and inferior disease disappears substantially.2. gastroscope check mucosa acute inflammation disappears substantially, and chronic inflammatory disease takes a turn for the better.3. biopsy proved by pathology gastroscope finding, more than the raw and dysplasia of body of gland atrophy, intestinalization recovers or alleviates two level degree.4. Acid Secretion and bile reflux are improved, and reach the more than 2/3 of former sick exceptional value amount.

3. effective: 1. cardinal symptom obviously alleviates.2. gastroscopy mucosa infection scope is dwindled more than 1/2, and inflammation alleviates to some extent.3. biopsy proved by pathology gastroscope finding, more than Acute and chronic inflammation alleviates a level degree, body of gland atrophy, intestinalization life and dysplasia alleviate.4. Acid Secretion and bile reflux are improved, and reach the more than 1/2 of former exceptional value amount.

4. invalid: do not reach the case of effective standard, and deterioration person not.

5. worsen: have one of following index: 1. main and minor symptom obviously increases the weight of.2. the expansion of stomach through mucous membrane extent of disease reaches more than 1/2, or pathological changes performance increases the weight of to some extent.Or other pathological changes that occurred together.3. biopsy pathology increases the weight of, and body of gland atrophy, intestinalization life and dysplasia, worsen the level degree that rises.4. Acid Secretion and bile reflux worsen, and reach the more than 1/2 of former sick exceptional value amount.

Therapeutic outcome

Table 1 is the therapeutic outcome contrast of each group

Group	Short Term Clinical is cured	Effective	Effectively	Invalid	Worsen
						Treatment by Chinese herbs group	97（97%）	2（2%）	1（1%）	0（0%）	0（0%）
Western medicine group	70（70%）	2（2%）	4（4%）	10（10%）	14（14%）

As can be seen from Table 1, the Short Term Clinical for the treatment of by Chinese herbs group is cured number will be far away higher than western medicine group, and hence one can see that, Chinese medicine composition of the present invention, and in treatment spleen and stomach damp-heat type chronic gastritis, therapeutic effect is good, determined curative effect.

Table 2 is that the Short Term Clinical of each group is cured and effective number treatment time contrast

Group	Short Term Clinical is cured and effective number	The 1st course for the treatment of	The 2nd course for the treatment of	The 3rd course for the treatment of
					Treatment by Chinese herbs group	99	60（60.61%）	30（30.30%）	9（9.09%）
Western medicine group	72	20（27.78%）	32（44.44%）	20（27.78%）

As can be seen from Table 2, the Short Term Clinical for the treatment of by Chinese herbs group is cured and effective number, and on treatment time, after the treatment of the 1st, 2 courses for the treatment of, effect is just good compared with the treatment situation of western medicine group.Hence one can see that, Chinese medicine composition of the present invention, and in treatment spleen and stomach damp-heat type chronic gastritis, treatment time is short, and treatment speed is fast.

Table 3 is that the Short Term Clinical of each group is cured and the side effect in therapeutic process of effective number contrasts

Group	Short Term Clinical is cured and effective number	Side effect
			Treatment by Chinese herbs group	99	0
Western medicine group	72	10（13.89%）

Can be found out by table, in therapeutic process, there is not any side effect in treatment by Chinese herbs group, and side effect appears in western medicine group: slight xerostomia 5 examples, 4 examples of stomach discomfort sense, 1 example of mammary swelling pain.Hence one can see that, and Chinese medicine composition of the present invention, in treatment spleen and stomach damp-heat type chronic gastritis, is free from side effects, more safer than Western medicine.

To sum up, Chinese medicine composition of the present invention, the hot gastritis for the treatment of spleen and stomach damp-heat type, therapeutic effect is good, determined curative effect, treatment time is short, and is free from side effects.

Model case: Wang, male, 35 years old, suffers from spleen and stomach damp-heat type chronic gastritis existing 2 years, Symptoms is: the scorching hot distending pain of gastral cavilty, and bitter to the taste, halitosis, yellowish urine, gastral cavity abdomen painful abdominal mass is vexed, thirst but no desire to drink, gastric mucosa is acute, Active inflammation, congested obviously rotten to the corn, is diagnosed as spleen and stomach damp-heat type chronic gastritis.Take the syrup of Chinese medicine composition embodiment 2 of the present invention, 2 times on the one 7 days is a course for the treatment of, treats 3 the Short Term Clinical healings course for the treatment of, and clinical cardinal symptom disappears, and no side effects in treatment, follows up a case by regular visits to and do not recur half a year.

 

The foregoing is only preferred embodiment of the present invention, in order to limit the present invention, within the spirit and principles in the present invention not all, any amendment of doing, be equal to replacement, improvement etc., within all should being included in protection scope of the present invention.

Claims (10)

1. treat the Chinese medicine composition of spleen and stomach damp-heat type chronic gastritis for one kind, it is characterized in that, comprise following raw medicinal material: Rhizoma Phragmitis, Radix Scutellariae, Rhizoma Coptidis, Radix Berberidis, Rhizoma Imperatae, Bombyx mori L., Fructus Chaenomelis, Herba Aristolochiae Mollissimae, Caulis Sinomenii, geranium, Semen Lablab Album, Herba Pogostemonis, Herba Eupatorii, Fructus Amomi Rotundus, Herba Abri, Radix Aristolochiae, fevervine, Semen Arecae, Lignum Dalbergiae Odoriferae, Rhizoma Fagopyri Dibotryis, Semen Mume, Canis familiaris L. ant grass, Fructus Sapindi Mukouossi, Oleum Camelliae, Herba Urariae crinitae, Fructus Amomi, Rhizoma Cyperi, Rhizoma valerianae latifoliae, Herba potamogetonis distincti's root, Radix Angelicae Pubescentis, Exocarpium Citri Grandis, Liquor Fructus Fortunellae Distillata, Herba Gnaphalii uliginosi.

2. Chinese medicine composition as claimed in claim 1, is characterized in that, in described Chinese medicine composition, the ratio of weight and number of each raw medicinal material is: Rhizoma Phragmitis 10-30 weight portion, Radix Scutellariae 12-25 weight portion, Rhizoma Coptidis 10-20 weight portion, Radix Berberidis 4-9 weight portion, Rhizoma Imperatae 10-20 weight portion, Bombyx mori L. 13-28 weight portion, Fructus Chaenomelis 10-28 weight portion, Herba Aristolochiae Mollissimae 10-25 weight portion, Caulis Sinomenii 10-30 weight portion, geranium 10-27 weight portion, Semen Lablab Album 15-26 weight portion, Herba Pogostemonis 6-10 weight portion, Herba Eupatorii 10-20 weight portion, Fructus Amomi Rotundus 15-30 weight portion, Herba Abri 10-24 weight portion, Radix Aristolochiae 7-10 weight portion, fevervine 12-24 weight portion, Semen Arecae 10-20 weight portion, Lignum Dalbergiae Odoriferae 6-10 weight portion, Rhizoma Fagopyri Dibotryis 14-29 weight portion, Semen Mume 10-20 weight portion, Canis familiaris L. ant grass 15-30 weight portion, Fructus Sapindi Mukouossi 12-26 weight portion, Oleum Camelliae 10-20 weight portion, Herba Urariae crinitae 15-26 weight portion, Fructus Amomi 10-30 weight portion, Rhizoma Cyperi 14-25 weight portion, Rhizoma valerianae latifoliae 15-27 weight portion, the root 10-25 of Herba potamogetonis distincti weight portion, Radix Angelicae Pubescentis 10-30 weight portion, Exocarpium Citri Grandis 10-26 weight portion, Liquor Fructus Fortunellae Distillata 14-30 weight portion and Herba Gnaphalii uliginosi 10-20 weight portion.

3. Chinese medicine composition as claimed in claim 1 or 2, is characterized in that, in described Chinese medicine composition, the ratio of weight and number of each raw medicinal material is: Rhizoma Phragmitis 20-30 weight portion, Radix Scutellariae 12-20 weight portion, Rhizoma Coptidis 15-20 weight portion, Radix Berberidis 4-5 weight portion, Rhizoma Imperatae 15-20 weight portion, Bombyx mori L. 23-28 weight portion, Fructus Chaenomelis 20-28 weight portion, Herba Aristolochiae Mollissimae 15-25 weight portion, Caulis Sinomenii 20-30 weight portion, geranium 15-27 weight portion, Semen Lablab Album 15-20 weight portion, Herba Pogostemonis 6-7 weight portion, Herba Eupatorii 15-20 weight portion, Fructus Amomi Rotundus 25-30 weight portion, Herba Abri 10-20 weight portion, Radix Aristolochiae 7-8 weight portion, fevervine 15-24 weight portion, Semen Arecae 15-20 weight portion, Lignum Dalbergiae Odoriferae 6-8 weight portion, Rhizoma Fagopyri Dibotryis 14-20 weight portion, Semen Mume 15-20 weight portion, Canis familiaris L. ant grass 25-30 weight portion, Fructus Sapindi Mukouossi 22-26 weight portion, Oleum Camelliae 15-20 weight portion, Herba Urariae crinitae 15-20 weight portion, Fructus Amomi 20-30 weight portion, Rhizoma Cyperi 14-20 weight portion, Rhizoma valerianae latifoliae 15-20 weight portion, the root 15-25 of Herba potamogetonis distincti weight portion, Radix Angelicae Pubescentis 20-30 weight portion, Exocarpium Citri Grandis 15-26 weight portion, Liquor Fructus Fortunellae Distillata 24-30 weight portion and Herba Gnaphalii uliginosi 15-20 weight portion.

4. the Chinese medicine composition as described in claims 1 to 3 any one, it is characterized in that, in described Chinese medicine composition, the ratio of weight and number of each raw medicinal material is: Rhizoma Phragmitis 15 weight portions, Radix Scutellariae 25 weight portions, Rhizoma Coptidis 10 weight portions, Radix Berberidis 9 weight portions, Rhizoma Imperatae 12 weight portions, Bombyx mori L. 18 weight portions, Fructus Chaenomelis 18 weight portions, Herba Aristolochiae Mollissimae 14 weight portions, Caulis Sinomenii 15 weight portions, geranium 14 weight portions, Semen Lablab Album 24 weight portions, Herba Pogostemonis 8 weight portions, Herba Eupatorii 14 weight portions, Fructus Amomi Rotundus 20 weight portions, Herba Abri 24 weight portions, Radix Aristolochiae 9 weight portions, fevervine 14 weight portions, Semen Arecae 14 weight portions, Lignum Dalbergiae Odoriferae 9 weight portions, Rhizoma Fagopyri Dibotryis 29 weight portions, Semen Mume 14 weight portions, Canis familiaris L. ant grass 20 weight portions, Fructus Sapindi Mukouossi 16 weight portions, Oleum Camelliae 14 weight portions, Herba Urariae crinitae 26 weight portions, Fructus Amomi 18 weight portions, Rhizoma Cyperi 25 weight portions, Rhizoma valerianae latifoliae 25 weight portions, Herba potamogetonis distincti's root 14 weight portions, Radix Angelicae Pubescentis 17 weight portions, Exocarpium Citri Grandis 14 weight portions, Liquor Fructus Fortunellae Distillata 20 weight portions and Herba Gnaphalii uliginosi 14 weight portions.

5. the Chinese medicine composition as described in claim 1 to 4 any one, it is characterized in that, in described Chinese medicine composition, the ratio of weight and number of each raw medicinal material is: Rhizoma Phragmitis 25 weight portions, Radix Scutellariae 18 weight portions, Rhizoma Coptidis 20 weight portions, Radix Berberidis 5 weight portions, Rhizoma Imperatae 15 weight portions, Bombyx mori L. 23 weight portions, Fructus Chaenomelis 25 weight portions, Herba Aristolochiae Mollissimae 20 weight portions, Caulis Sinomenii 25 weight portions, geranium 17 weight portions, Semen Lablab Album 18 weight portions, Herba Pogostemonis 6 weight portions, Herba Eupatorii 20 weight portions, Fructus Amomi Rotundus 25 weight portions, Herba Abri 15 weight portions, Radix Aristolochiae 7 weight portions, fevervine 20 weight portions, Semen Arecae 18 weight portions, Lignum Dalbergiae Odoriferae 6 weight portions, Rhizoma Fagopyri Dibotryis 18 weight portions, Semen Mume 20 weight portions, Canis familiaris L. ant grass 28 weight portions, Fructus Sapindi Mukouossi 26 weight portions, Oleum Camelliae 20 weight portions, Herba Urariae crinitae 18 weight portions, Fructus Amomi 27 weight portions, Rhizoma Cyperi 18 weight portions, Rhizoma valerianae latifoliae 18 weight portions, Herba potamogetonis distincti's root 25 weight portions, Radix Angelicae Pubescentis 26 weight portions, Exocarpium Citri Grandis 26 weight portions, Liquor Fructus Fortunellae Distillata 27 weight portions and Herba Gnaphalii uliginosi 18 weight portions.

6. the Chinese medicine composition as described in claim 1 to 5 any one, is characterized in that, when the dosage form of described Chinese medicine composition is oral solutions, its preparation method is:

The first step, Rhizoma Phragmitis, Radix Scutellariae, Rhizoma Coptidis, Radix Berberidis and Rhizoma Imperatae are mixed, the alcohol reflux that to add with respect to 2 times～4 times, mixture amount determining alcohols be 75%～80% 2 times～4 times, each 2 hours～3 hours, filter, filtrate merges, and reclaims ethanol, be concentrated into the mastic that 70 DEG C of relative densities are 1.20～1.22, for subsequent use;

Second step, is mixed in proportion described residue raw medicinal material, adds with respect to 3～5 times of water gagings of mixture, boils 2～4 hours, filters, and is concentrated into the mastic that 70 DEG C of relative densities are 1.21～1.24;

The 3rd step, the described mastic that the first step, second step are obtained mixes, and 55 DEG C～65 DEG C reduced vacuum are dry, and powder gets dry extract;

The 4th step, will the 3rd add ethanol in the described dried cream powder that obtains of step, obtain containing alcohol mastic, and described is 75%～780% containing alcohol mastic containing alcohol amount; Carry out successively cold preservation processing, precipitation process, filtration treatment, recovery Ethanol Treatment by described containing alcohol mastic, obtain dealcoholysis mastic, wherein, the cold preservation processing time is 30～40 hours;

The 5th step, will add cane sugar powder, active carbon in described dealcoholysis mastic, carries out successively heat treated, filtration treatment, dilution process, obtains semi-finished product; The weight ratio of described dealcoholysis mastic and described cane sugar powder is 1: 0.12～0.3; The weight ratio of described dealcoholysis mastic and described active carbon is 1: 0.001～0.002; The time of described heat treated is 30～40 minutes, and temperature is 100 DEG C～110 DEG C;

The 6th step, the more described semi-finished product of the 5th step acquisition are carried out to filtration treatment, embedding processing, sterilization treatment successively, obtain described Chinese medicine preparation oral liquid finished product.

7. the Chinese medicine composition as described in claim 1 to 5 any one, is characterized in that, when the dosage form of described Chinese medicine composition is syrup, its preparation method is:

The first step, Rhizoma Phragmitis, Radix Scutellariae, Rhizoma Coptidis, Radix Berberidis, Rhizoma Imperatae, Bombyx mori L., Fructus Chaenomelis, Herba Aristolochiae Mollissimae, Caulis Sinomenii, geranium, Semen Lablab Album and Herba Pogostemonis are mixed in described ratio, use the dissolve with ethanol with respect to the determining alcohol 80%～90% of 2～4 times of the mixture quality obtaining, reflux was extracted after 2～4 hours, filter, obtain the first filtrate; Filtering residue is used to the dissolve with ethanol with respect to the determining alcohol 80%～90% of 1～2 times of the mixture quality obtaining again, and reflux was extracted after 1～2 hour, filtered, and obtained the second filtrate; Merge the first filtrate and the second filtrate, decompression recycling ethanol to be concentrated into liquor strength be 0.7～0.9g crude drug/mL, utilize the macroporous adsorptive resins eluting that volume is 5L, first use deionized water or the distilled water eluting of 6 times of resin column volumes, be 90%～95% ethanol elution with the determining alcohol of 3 times of resin column volumes again, collect ethanol elution, concentrating under reduced pressure is removed ethanol, is dried and is ground into powder;

Second step, Herba Eupatorii, Fructus Amomi Rotundus, Herba Abri and Radix Aristolochiae are mixed in described ratio, add with respect to obtain mixture quality the determining alcohol 85%～90% of 2～4 times alcohol heating reflux extract 1～2 time, extracting solution merges, with the centrifugal remove impurity of tube centrifuge, the mastic that when extracting solution after remove impurity is evaporated to 60 DEG C under the condition of 65 DEG C～70 DEG C, relative density is 1.22～1.25, is dried to powder by the mastic after concentrated with spray dryer;

The 3rd step, mixes surplus stock medical material in described ratio, add the water dissolution of 2～4 times with respect to the mixture quality obtaining, and heating decocts 2～3 hours, filters; Filtering residue is used to the water dissolution of 1～2 times with respect to the mixture quality obtaining again, and heating decocts 1～2 hour, filters; Merge the filtrate of twice, concentrating under reduced pressure is removed moisture, is dried and is ground into powder;

The 4th step, the powder that the first step, second step and the 3rd step are obtained mixes, add the water dissolution with respect to 1.5～3 times of mixture qualities, with 50% sodium hydroxide solution adjusting pH value to 7.0, stir evenly cold preservation 48 hours～72 hours under 10 DEG C～14 DEG C conditions, filter, filtrate adds the sucrose with respect to 0.3～0.4 times of the mixture quality obtaining, and stirs and dissolves, and regulates pH value to 7.0, add water appropriate, stir, static 12～20 hours, filter, fill, sterilizing, obtains syrup, and the crude drug concentration in described syrup is 1.2 g/mL～1.5g/mL.

8. a preparation method for the Chinese medicine composition described in claim 1 to 5 any one, is characterized in that, the dosage form of described Chinese medicine composition is oral solutions, and its preparation method is:

The first step, Rhizoma Phragmitis, Radix Scutellariae, Rhizoma Coptidis, Radix Berberidis and Rhizoma Imperatae are mixed, the alcohol reflux that to add with respect to 2 times～4 times, mixture amount determining alcohols be 75%～80% 2 times～4 times, each 2 hours～3 hours, filter, filtrate merges, and reclaims ethanol, be concentrated into the mastic that 70 DEG C of relative densities are 1.20～1.22, for subsequent use;

Second step, is mixed in proportion described residue raw medicinal material, adds with respect to 3～5 times of water gagings of mixture, boils 2～4 hours, filters, and is concentrated into the mastic that 70 DEG C of relative densities are 1.21～1.24;

The 3rd step, the described mastic that the first step, second step are obtained mixes, and 55 DEG C～65 DEG C reduced vacuum are dry, and powder gets dry extract;

The 4th step, will the 3rd add ethanol in the described dried cream powder that obtains of step, obtain containing alcohol mastic, and described is 75%～80% containing alcohol mastic containing alcohol amount; Carry out successively cold preservation processing, precipitation process, filtration treatment, recovery Ethanol Treatment by described containing alcohol mastic, obtain dealcoholysis mastic, wherein, the cold preservation processing time is 30～40 hours;

The 5th step, will add cane sugar powder, active carbon in described dealcoholysis mastic, carries out successively heat treated, filtration treatment, dilution process, obtains semi-finished product; The weight ratio of described dealcoholysis mastic and described cane sugar powder is 1: 0.12～0.3; The weight ratio of described dealcoholysis mastic and described active carbon is 1: 0.001～0.002; The time of described heat treated is 30～40 minutes, and temperature is 100 DEG C～110 DEG C;

The 6th step, the more described semi-finished product of the 5th step acquisition are carried out to filtration treatment, embedding processing, sterilization treatment successively, obtain described Chinese medicine preparation oral liquid finished product.

9. a preparation method for the Chinese medicine composition described in claim 1 to 5 any one, is characterized in that, the dosage form of described Chinese medicine composition is syrup, and its preparation method is:

The first step, Rhizoma Phragmitis, Radix Scutellariae, Rhizoma Coptidis, Radix Berberidis, Rhizoma Imperatae, Bombyx mori L., Fructus Chaenomelis, Herba Aristolochiae Mollissimae, Caulis Sinomenii, geranium, Semen Lablab Album and Herba Pogostemonis are mixed in described ratio, use the dissolve with ethanol with respect to the determining alcohol 80%～90% of 2～4 times of the mixture quality obtaining, reflux was extracted after 2～4 hours, filter, obtain the first filtrate; Filtering residue is used to the dissolve with ethanol with respect to the determining alcohol 80%～90% of 1～2 times of the mixture quality obtaining again, and reflux was extracted after 1～2 hour, filtered, and obtained the second filtrate; Merge the first filtrate and the second filtrate, decompression recycling ethanol to be concentrated into liquor strength be 0.7～0.9g crude drug/mL, utilize the macroporous adsorptive resins eluting that volume is 5L, first use deionized water or the distilled water eluting of 6 times of resin column volumes, be 90%～95% ethanol elution with the determining alcohol of 3 times of resin column volumes again, collect ethanol elution, concentrating under reduced pressure is removed ethanol, is dried and is ground into powder;

Second step, Herba Eupatorii, Fructus Amomi Rotundus, Herba Abri and Radix Aristolochiae are mixed in described ratio, add with respect to obtain mixture quality the determining alcohol 85%～90% of 2～4 times alcohol heating reflux extract 1～2 time, extracting solution merges, with the centrifugal remove impurity of tube centrifuge, the mastic that when extracting solution after remove impurity is evaporated to 60 DEG C under the condition of 65 DEG C～70 DEG C, relative density is 1.22～1.25, is dried to powder by the mastic after concentrated with spray dryer;

The 3rd step, mixes surplus stock medical material in described ratio, add the water dissolution of 2～4 times with respect to the mixture quality obtaining, and heating decocts 2～3 hours, filters; Filtering residue is used to the water dissolution of 1～2 times with respect to the mixture quality obtaining again, and heating decocts 1～2 hour, filters; Merge the filtrate of twice, concentrating under reduced pressure is removed moisture, is dried and is ground into powder;

The 4th step, the powder that the first step, second step and the 3rd step are obtained mixes, add the water dissolution with respect to 1.5～3 times of mixture qualities, with 50% sodium hydroxide solution adjusting pH value to 7.0, stir evenly cold preservation 48 hours～72 hours under 10 DEG C～14 DEG C conditions, filter, filtrate adds the sucrose with respect to 0.3～0.4 times of the mixture quality obtaining, and stirs and dissolves, and regulates pH value to 7.0, add water appropriate, stir, static 12～20 hours, filter, fill, sterilizing, obtains syrup, and the crude drug concentration in described syrup is 1.2 g/mL～1.5g/mL.

10. the Chinese medicine composition as described in claim 1 to 5 any one, it is characterized in that, the dosage form of described Chinese medicine composition is: sugar coated tablet, film coated tablet, enteric coated tablet, hard capsule, soft capsule, oral liquid, suck agent, granule, electuary, honey pill agent, powder, sublimed preparation, solution, injection, suppository, plaster, syrup, powder and patch.