CN103071138B - Chinese medicinal composition for treating chronic gastritis as well as preparation method and application - Google Patents

Chinese medicinal composition for treating chronic gastritis as well as preparation method and application Download PDF

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CN103071138B
CN103071138B CN201310044585.2A CN201310044585A CN103071138B CN 103071138 B CN103071138 B CN 103071138B CN 201310044585 A CN201310044585 A CN 201310044585A CN 103071138 B CN103071138 B CN 103071138B
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parts
rhizoma
radix
fructus
chronic gastritis
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CN103071138A (en
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陈建章
王小平
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Jiangxi College of Traditional Chinese Medicine
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Jiangxi College of Traditional Chinese Medicine
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Abstract

The invention discloses a Chinese medicinal composition for treating chronic gastritis. The Chinese medicinal composition is characterized by comprising the following bulk pharmaceutical herbs in parts by weight: 10-14 parts of heterophylly falsestarwort root, 10-20 parts of white atractylodes rhizome, 10-20 parts of poria cocos, 8-12 parts of ginger processed pinellia, 1-5 parts of medicinal evodia fruit, 8-12 parts of Chinese thorowax root, 8-16 parts of akebia fruit, 2-6 parts of dried ginger, 10-20 parts of immature bitter orange, 6-10 parts of dried tangerine or orange peel, 6-10 parts of officinal magnolia bark, 8-12 parts of baical skullcap root, 2-6 parts of coptis root, 12-18 parts of cuttlefish bone, 9-15 parts of corydalis tuber, and 12-18 parts of common bletilla pseudobulb. A better effect can be achieved by adding notholirion bulbuliferum, bract machilus bark, angelica polymorpha Maxim and lovely hemsleya root. Meanwhile, a modern superfine grinding technology and a cell disruption technology are adopted to prepare Chinese medicinal superfine powder, and the Chinese medicinal composition can be orally taken directly or taken after being mixed with boiled water, can be used to rapidly alleviate symptoms of the chronic gastritis, has stronger effects of invigorating spleen, supplementing qi, warming and harmonizing stomach, and promoting qi circulation to relieve pain, treats both symptoms and root causes, has a rapid curative effect, and is convenient to produce and take and low in preparation cost at the same time, thereby having good popularization values.

Description

A kind of Chinese medicine composition and preparation method and application that treat chronic gastritis
Technical field
The present invention relates to a kind of Chinese medicine composition and preparation method and application that treat chronic gastritis, belong to the field of Chinese medicines.
Background technology
Chronic gastritis refers to that the chronic inflammatory disease of the gastric mucosa that a variety of causes causes sexually revises, a kind of commonly encountered diseases, frequently-occurring disease, its generation and drinking and eating irregularly, psychentonia factors are relevant, quickening along with people's rhythm of life, being growing more intense of various competitions, the sickness rate of chronic gastritis has the trend of continuous rising.Although there is no at present the report of the sickness rate in a large amount of crowds, it is generally acknowledged that its morbidity increases with age growth.There is data to show in the people of 20~40 years old that people's gastric mucosa of 47% still belongs to normally, and in above crowd, only have for 18% Genus Homo normal range in 60 years old.When old people becomes celestial, concurrent chronic gastritis person is very common.There is this sick sickness rate of external report may account for entire population's 30%.Although China there is not yet report, according to the routine fibergastroscopy in Jiangsu 49226, to find, chronic gastritis accounts for 54.92%.Also have 80~90% inflammation that have a gastric mucosa in the gastroscopic patient of report, and male is more than women.
The touching delay of the normal state of an illness of chronic gastritis, although modern medicine has the method for numerous treatment chronic gastritiss, there is no so far specific treatment, moreover can there is the complication such as gastric ulcer, upper gastrointestinal hemorrhage, anemia, gastric cancer, polyp of stomach in chronic gastritis.Therefore, take active and effective measure, it is very necessary that chronic gastritis is carried out to effectively treatment.
Motherland's medical science has just had the record of chronic gastritis (claiming " gastric abscess " in < < in > >) in < < in > >.Chronic gastritis belongs to the categories such as Chinese medicine " gastric abscess ", " feeling of fullness ", wherein mainly with " gastric abscess ", discusses more." gastric abscess " claims again " stomachache ", is that to take under the heart be that gastral cavilty portion pain is main a kind of syndrome on umbilicus.It is the closest that the generation of gastric abscess and cold-evil violate stomach, eating and drinking without temperance and the uncomfortable relation of feelings will.In < <, through > >, first the pathogenic viewpoint of cold-evil has been proposed, " cold limbs enters stomach; raw pained ... heart stomach is raw cold; chest and diaphragm is unfavorable; pained feeling of fullness " [Plain Questions the most pure virginity will be discussed greatly], " cold visitor is between gastrointestinal ... little network draws urgency, therefore pain ", " cold visitor is in the intestines and stomach ... thus pain and vomit also " [Plain Questions lift pain opinion], having set forth cold-evil, to violate stomach be the main cause that causes gastric abscess.In < <, through > >, injury due to diet has also been proposed simultaneously, it is also the major reason that causes gastric abscess that feelings will is lost freely, as " eating twice as usual; the intestines and stomach is wound " [Plain Questions numbness opinion], " strongly fragrant the sending out of wood ..., therefore the sick epigastralgia right below the heart of the people; inappetence " [the hexa-atomic large opinion of just recording of Plain Questions], " the nether world sky of fainting, wind is excessive to be won ..., the sick epigastralgia right below the heart of the people ... inappetence " and [Plain Questions the most pure virginity will be discussed greatly].The cold-evil who proposes through > > in < < is caused a disease, established the etiologic etiological basis of gastric abscess due to injury due to diet and feelings will.Later many doctors continue to use the etiology viewpoint through > > in < < more and instruct Coryza Treated by Syndrome Differentiation, and have many doctors further to bring into play on this basis, make it more perfect.As gold dollar period, Liu Wansu is in disease > >, to be loaded with " or heat stagnation is in interior, and the hard knot of abdominal distention pain person can not say and tremble with fear also " at < < cause of disease formula six gas; Clear leaf sky scholar has clearly proposed the viewpoint of heat transformed from stagnated cold, " examine interior through all pains, all main cold visitor, but pain of a specified duration for years, cold must heat-dissipating " [Linzheng Zhinan Yi], and it take blood stasis theory as foundation, has proposed the famous theory argument of " sick just at warp, pain enters network for a long time ".
Therefore, the etiology and pathogenesis of gastric abscess is mainly cold-evil visitor stomach, eating and drinking without temperance, and taste are injured, thereby cause weakness of the spleen and stomach, or the double stagnation of QI, or double food stagnation, or it is hot and suffocating to hold concurrently, or double blood stasis etc., affect the transporting of taste, retention of heat due to blockage of dampness, as met again feelings will, stimulate depression of liver-QI, horizontal criminal's taste, therefore the vexed distension of gastral cavilty portion painful abdominal mass, and often after feed, occur or aggravation, or have noisy burn feeling, pain is without syndrome of stagnation of QI such as timing grade, and the stagnation of QI can the hyperamization stasis of blood, and then causes gastralgia.Based on this, chronic gastritis should be take invigorating the spleen and benefiting QI, warming middle-JIAO for easing the stomach, the promoting the circulation of QI to relieve pain basic rule for the treatment of that heat clearing away is its treatment of holding concurrently.
In the prior art, it is the one of the main reasons that causes gastric abscess that < < Chinese medicine composition for the treatment of gastritis and preparation method thereof > > CN1919331 has ignored " cold-evil violates stomach ", proposition take regulate the flow of vital energy, invigorating middle warmer, damp eliminating be the rule for the treatment of, if exopathogen does not remove and the invigorating middle warmer of only regulating the flow of vital energy, clinical efficacy is probably difficult to be guaranteed; In the etiology and pathogenesis of gastric abscess, cold-evil, diet, emotion are all risk factors, its disease be originally weakness of the spleen and stomach, the Chinese medicine > > CN101332285A of a < < formula for treating gastropathy proposes dissipating depression and moistening for dryness, sending down the abnormal ascending QI removing dampness, soothing liver-QI stomach function regulating method for the treatment of, only emphasize that emotion, diet cause a disease, ignored the basic and risk factor cold-evil of the disease of weakness of the spleen and stomach; Because of the long deficient symptom that easily causes weakness of the spleen and stomach of most chronic gastritis course of disease, < < Chinese medicine composition > > CN102397516A who treats chronic gastritis has taken into full account cold-evil, the impact of emotion in gastric abscess causes a disease in prescription, but has ignored invigorating the spleen and benefiting QI to entangle weakness of the spleen and stomach originally.
Before the prepared slices of Chinese crude drugs are prepared into various dosage forms, generally need be through pretreatment procedures such as extracting separation, concentrate and be dried, all be accompanied by long-time heating process, easily causing wherein chemical composition changes, especially be rich in the Chinese medicine that is subject to thermally labile or volatile component, cause active constituent content to decline, and then drug absorption reduce, bioavailability reduces, and curative effect of medication weakens.Meanwhile, due to complex procedures, the operating time is long, and production efficiency declines, and causes production cost significantly to improve, and affects economic benefit and the capability of sustainable development of enterprise.
Summary of the invention
Object of the present invention be exactly to provide a kind of have better curative effect, take into account Chinese medicine composition and preparation method and application that the treatment chronic gastritis of dialectical prescription is carried out in the aspects such as void, reality, cold, heat, gas, blood.
The present invention is achieved in that from aspects such as empty, real, cold, heat, gas, blood chronic gastritis (i.e. " gastric abscess ") is carried out to dialectical prescription, obtains clinically better effects.We are comprised of 20 kinds of Chinese medicines such as Radix Pseudostellariae, the Rhizoma Atractylodis Macrocephalae, Poria, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), Fructus Evodiae, Radix Bupleuri, Bullus Notholirionis Bulbuliferi, Fructus Akebiae, Rhizoma Zingiberis, Fructus Aurantii Immaturus, Radix seu Cortex Machili bracteatae, Pericarpium Citri Reticulatae, Zijin sand, Cortex Magnoliae Officinalis, Radix Scutellariae, Rhizoma Coptidis, Radix Hemsleyae Macrospermae, Endoconcha Sepiae, Rhizoma Corydalis, Pseudobulbus Bletillae (Rhizoma Bletillae).Radix Pseudostellariae, the Rhizoma Atractylodis Macrocephalae, Poria in side, invigorating the spleen and benefiting QI is monarch drug, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), Fructus Evodiae, Rhizoma Zingiberis, Radix Bupleuri, Bullus Notholirionis Bulbuliferi, Fructus Akebiae, warming middle-JIAO to send down the adverse QI, depressed liver-energy dispersing and QI regulating stomach function regulating are ministerial drug, be equipped with Radix seu Cortex Machili bracteatae, Pericarpium Citri Reticulatae, Zijin sand, Fructus Aurantii Immaturus, Cortex Magnoliae Officinalis, promoting the circulation of QI to relieve pain, removing food stagnancy are except full, and Radix Scutellariae, Rhizoma Coptidis, Radix Hemsleyae Macrospermae bitter cold are with hot and suffocating clearly, Endoconcha Sepiae antacid cuticula, Rhizoma Corydalis, Pseudobulbus Bletillae (Rhizoma Bletillae) are invigorated blood circulation, hemostasis, blood stasis dispelling.All medicines share, and play altogether the merit of invigorating the spleen and benefiting QI, warming middle-JIAO for easing the stomach, promoting the circulation of QI to relieve pain.Cure mainly weakness of the spleen and stomach, incoordination between the liver and stomach, cold and heat are also shown in, chronic gastritis due to simulataneous insufficiency and excessive.
One of technical solution of the present invention: a kind of Chinese medicine composition for the treatment of chronic gastritis, it is comprised of the crude drug of following weight portion: 10-14 parts of Radix Pseudostellariaes, 10-20 parts of the Rhizoma Atractylodis Macrocephalaes, 10-20 parts, Poria, 8-12 parts of Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens)s, 1-5 parts of Fructus Evodiaes, 8-12 parts of Radix Bupleuri, 8-16 parts of Fructus Akebiaes, 2-6 parts of Rhizoma Zingiberiss, 10-20 parts of Fructus Aurantii Immaturuss, 6-10 parts of Pericarpium Citri Reticulataes, 6-10 parts of Cortex Magnoliae Officinalis, 8-12 parts of Radix Scutellariaes, 2-6 parts of Rhizoma Coptidis, 12-18 parts of Endoconcha Sepiaes, 9-15 parts of Rhizoma Corydalis, 12-18 parts of Pseudobulbus Bletillae (Rhizoma Bletillae).
Preferred: the consumption of each crude drug is: 12 parts of Radix Pseudostellariaes, 15 parts of the Rhizoma Atractylodis Macrocephalaes, 15 parts, Poria, 10 parts of Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens)s, 3 parts of Fructus Evodiaes, 10 parts of Radix Bupleuri, 12 parts of Fructus Akebiaes, 4 parts of Rhizoma Zingiberiss, 15 parts of Fructus Aurantii Immaturuss, 8 parts of Pericarpium Citri Reticulataes, 8 parts of Cortex Magnoliae Officinalis, 10 parts of Radix Scutellariaes, 4 parts of Rhizoma Coptidis, 15 parts of Endoconcha Sepiaes, 12 parts of Rhizoma Corydalis, 15 parts of Pseudobulbus Bletillae (Rhizoma Bletillae).
Further: a kind of Chinese medicine composition for the treatment of chronic gastritis, it is comprised of the crude drug of following weight portion: 10-14 parts of Radix Pseudostellariaes, 10-20 parts of the Rhizoma Atractylodis Macrocephalaes, 6-12 parts, Poria, 3-9 parts of Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens)s, 1-5 parts of Fructus Evodiaes, 6-12 parts of Radix Bupleuri, 3-9 parts of Bullus Notholirionis Bulbuliferi, 6-12 parts of Fructus Akebiaes, 2-6 parts of Rhizoma Zingiberiss, 5-15 parts of Fructus Aurantii Immaturuss, 6-12 parts of Radix seu Cortex Machili bracteataes, 6-10 parts of Pericarpium Citri Reticulataes, 6-10 parts, Zijin sand, 6-10 parts of Cortex Magnoliae Officinalis, 3-9 parts of Radix Scutellariaes, 2-6 parts of Rhizoma Coptidis, 3-9 parts of Radix Hemsleyae Macrospermae, 12-18 parts of Endoconcha Sepiaes, 6-12 parts of Rhizoma Corydalis, 6-12 parts of Pseudobulbus Bletillae (Rhizoma Bletillae).
Further preferably: the consumption of each crude drug is: 12 parts of Radix Pseudostellariaes, 15 parts of the Rhizoma Atractylodis Macrocephalaes, 9 parts, Poria, 6 parts of Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens)s, 3 parts of Fructus Evodiaes, 9 parts of Radix Bupleuri, 6 parts of Bullus Notholirionis Bulbuliferi, 9 parts of Fructus Akebiaes, 4 parts of Rhizoma Zingiberiss, 10 parts of Fructus Aurantii Immaturuss, 9 parts of Radix seu Cortex Machili bracteataes, 8 parts of Pericarpium Citri Reticulataes, husky 8 parts of Zijin, 8 parts of Cortex Magnoliae Officinalis, 6 parts of Radix Scutellariaes, 4 parts of Rhizoma Coptidis, 6 parts of Radix Hemsleyae Macrospermae, 15 parts of Endoconcha Sepiaes, 9 parts of Rhizoma Corydalis, 9 parts of Pseudobulbus Bletillae (Rhizoma Bletillae).
Above-mentioned Chinese medicine composition has following dosage form: powder, hard capsule, soft capsule, tablet, pill.
Two of technical solution of the present invention: a kind of preparation technology who treats the Chinese medicine composition of chronic gastritis, comprises the steps:
By the prepared slices of Chinese crude drugs of each crude drug, in 60 ℃ dry 12 hours, mixed powder is broken into coarse powder, then puts into super micron mill, pulverizes 1~75 μ m superfine powder, obtains; Or get superfine powder and record capsule or soft capsule; Or get superfine powder and be pressed into tablet; Or get superfine powder and make pill.
Preparation technology uses the specification requirement > > of < < new Chinese medicine Study on Preparation in principle, the micron order medicine that uses superfine communication technique, Ultracytochemical wall breaking technology and modern preparation technique to be prepared from is used as medicine, and makes powder; Or add some accessory substances, as water, sugar, starch etc., make hard capsule, soft capsule, tablet, pill.
Three of technical solution of the present invention: the application of above-mentioned a kind of Chinese medicine composition for the treatment of chronic gastritis in treatment chronic gastritis Chinese medicine composition.
The application of above-mentioned a kind of Chinese medicine composition for the treatment of chronic gastritis in the Chinese medicine composition of preparation treatment chronic gastritis.
When oral the or boiled water of this Chinese medicine composition is taken after mixing it with water, every part adopts Ke Wei unit, every day potion, minute secondary is oral, be 2 months the course for the treatment of, can reach clinical cure effect.
The present invention adopts the hold concurrently method of heat clearing away of invigorating the spleen and benefiting QI, warming middle-JIAO for easing the stomach, promoting the circulation of QI to relieve pain, treatment chronic gastritis, and curative effect is better, and cure rate is high, and few side effects is 96.3% through clinical observation total effective rate.
beneficial effect of the present invention:
(1) the present invention link closely ancient Chinese medicine doctor about epigastric pain because of Pathogenesis Theory, i.e. " cold-evil visitor stomach, eating and drinking without temperance, feelings will are lost smooth; cause weakness of the spleen and stomach ", from aspect dialectical prescriptions such as empty, real, cold, heat, gas, blood, proposition be take invigorating the spleen and benefiting QI, warming middle-JIAO for easing the stomach, regulating qi to disperse stagnation and is held concurrently heat clearing away as basic therapy, both considered invigorating the spleen and benefiting QI with entangle weakness of the spleen and stomach this, take into account again cold-evil, diet and feelings will because of, realize treating both the principal and secondary aspects of a disease.Outstanding by clinical observation result proved compositions curative effect.
(2) the present invention selects some to imitate the special characteristic medicine of power, as Bullus Notholirionis Bulbuliferi, and the effect of tool the chest stuffiness relieving regulating QI to relieve pain; be usually used in heart peratodynia disease, and confirm through testing [Zhao Yinping, Li Ying. the progress of Chinese medicine Bullus Notholirionis Bulbuliferi [J]. Xi'an Joint Univ.'s journal; 2002,5 (1): 104-106; Geng Zengyan, Huang Yue, Chen Jinming. Bullus Notholirionis Bulbuliferi n-butyl alcohol extract is to the experimentation of rat chronic gastritis effect [J]. Jilin Chinese medicine, 2009,29 (6): 527-528], Bullus Notholirionis Bulbuliferi can obviously suppress the acute attack of gastric antrum portion mucosal inflammation, alleviates the gastric antrum portion inflammatory damage that ammonia causes, the damaging action that can improve and delay gastric mucosa, has good therapeutic effect to the treatment of chronic gastritis, atrophic gastritis; Radix Hemsleyae Macrospermae, have heat-clearing and toxic substances removing, the effect of benefiting stomach and stopping pain, is usually used in treatment stomachache, and confirm [as if flower bud through experiment, Qin Renan. Radix Hemsleyae Macrospermae is to the research of Experimental Gastric Ucler effect [J]. Chinese pharmacology communication, 2003,20 (1): 64], Radix Hemsleyae Macrospermae can make the ulcer area and the ulcer index that reduce Experimental Gastric Ulcer in Rats reduce, reduce rat gastric secretion, reduce gastric acidity and pepsin activity, and helicobacter pylori etc. is had to better antibacterial and bactericidal action, and anti-inflammatory and analgesic effect is outstanding; Zijin is husky, tool cold expelling, regulate the flow of vital energy, the merit of pain relieving, be exclusively used in treatment stomachache, stomachache, chest and hypochondrium, alone effectively [Xie Zongwan. national Chinese herbal medicine compilation. volume two [M]. Beijing: People's Health Publisher, 1996:615]; Radix seu Cortex Machili bracteatae, has the effect of warming middle-JIAO to promote flow of QI pain relieving, be exclusively used in stomach abdominal distention and pain, acute gastroenteritis treatment [Xie Zongwan. national Chinese herbal medicine compilation. volume two [M]. Beijing: People's Health Publisher, 1996:399]; Etc..
(3) the present invention is in conjunction with Study on Supermicro-pulverization of Traditional Chinese Drugs technology, Ultracytochemical wall breaking technology and modern preparation technique, the novel micron order Chinese medicine that this Chinese medicine composition is developed mutually, directly oral or increase mixing in water for oral taking, or be prepared into powder, hard capsule, soft capsule, tablet, pill etc.In preparation technology, there is not chemical change in raw material of Chinese medicine substantially, just changes physical behavior, retained the original characteristic of Chinese medicine, produces, takes very convenient, and can overcome it and decoct to extract trouble, take inconvenient shortcoming.By cell wall breaking, medicament effective component is fully discharged simultaneously, further improved clinical efficacy.
The specific embodiment
The present invention can specifically implement by the technology contents illustrating in summary of the invention, can conduct further description the present invention, yet scope of the present invention is not limited to following embodiment by the following examples.
Embodiment 1:
The crude drug of getting each composition weight portion is: 12 parts of Radix Pseudostellariaes, 15 parts of the Rhizoma Atractylodis Macrocephalaes, 15 parts, Poria, 10 parts of Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens)s, 3 parts of Fructus Evodiaes, 10 parts of Radix Bupleuri, 12 parts of Fructus Akebiaes, 4 parts of Rhizoma Zingiberiss, 15 parts of Fructus Aurantii Immaturuss, 8 parts of Pericarpium Citri Reticulataes, 8 parts of Cortex Magnoliae Officinalis, 10 parts of Radix Scutellariaes, 4 parts of Rhizoma Coptidis, 15 parts of Endoconcha Sepiaes, 12 parts of Rhizoma Corydalis, 15 parts of Pseudobulbus Bletillae (Rhizoma Bletillae).
Embodiment 2:
The crude drug of getting each composition weight portion is: 10 parts of Radix Pseudostellariaes, 20 parts of the Rhizoma Atractylodis Macrocephalaes, 20 parts, Poria, 10 parts of Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens)s, 4 parts of Fructus Evodiaes, 12 parts of Radix Bupleuri, 15 parts of Fructus Akebiaes, 2 parts of Rhizoma Zingiberiss, 18 parts of Fructus Aurantii Immaturuss, 10 parts of Pericarpium Citri Reticulataes, 10 parts of Cortex Magnoliae Officinalis, 9 parts of Radix Scutellariaes, 5 parts of Rhizoma Coptidis, 12 parts of Endoconcha Sepiaes, 15 parts of Rhizoma Corydalis, 16 parts of Pseudobulbus Bletillae (Rhizoma Bletillae).
Embodiment 3:
The crude drug of getting each composition weight portion is: 14 parts of Radix Pseudostellariaes, 14 parts of the Rhizoma Atractylodis Macrocephalaes, 16 parts, Poria, 8 parts of Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens)s, 2 parts of Fructus Evodiaes, 8 parts of Radix Bupleuri, 10 parts of Fructus Akebiaes, 4 parts of Rhizoma Zingiberiss, 12 parts of Fructus Aurantii Immaturuss, 9 parts of Pericarpium Citri Reticulataes, 9 parts of Cortex Magnoliae Officinalis, 12 parts of Radix Scutellariaes, 4 parts of Rhizoma Coptidis, 18 parts of Endoconcha Sepiaes, 18 parts of Rhizoma Corydalis, 15 parts of Pseudobulbus Bletillae (Rhizoma Bletillae).
Embodiment 4:
The crude drug of getting each composition weight portion is: 14 parts of Radix Pseudostellariaes, 12 parts of the Rhizoma Atractylodis Macrocephalaes, 14 parts, Poria, 12 parts of Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens)s, 5 parts of Fructus Evodiaes, 9 parts of Radix Bupleuri, 8 parts of Fructus Akebiaes, 5 parts of Rhizoma Zingiberiss, 10 parts of Fructus Aurantii Immaturuss, 6 parts of Pericarpium Citri Reticulataes, 6 parts of Cortex Magnoliae Officinalis, 10 parts of Radix Scutellariaes, 3 parts of Rhizoma Coptidis, 16 parts of Endoconcha Sepiaes, 15 parts of Rhizoma Corydalis, 12 parts of Pseudobulbus Bletillae (Rhizoma Bletillae).
Embodiment 5:
The crude drug of getting each composition weight portion is: 12 parts of Radix Pseudostellariaes, 15 parts of the Rhizoma Atractylodis Macrocephalaes, 9 parts, Poria, 6 parts of Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens)s, 3 parts of Fructus Evodiaes, 9 parts of Radix Bupleuri, 6 parts of Bullus Notholirionis Bulbuliferi, 9 parts of Fructus Akebiaes, 4 parts of Rhizoma Zingiberiss, 10 parts of Fructus Aurantii Immaturuss, 9 parts of Radix seu Cortex Machili bracteataes, 8 parts of Pericarpium Citri Reticulataes, husky 8 parts of Zijin, 8 parts of Cortex Magnoliae Officinalis, 6 parts of Radix Scutellariaes, 4 parts of Rhizoma Coptidis, 6 parts of Radix Hemsleyae Macrospermae, 15 parts of Endoconcha Sepiaes, 9 parts of Rhizoma Corydalis, 9 parts of Pseudobulbus Bletillae (Rhizoma Bletillae).
Embodiment 6:
The crude drug of getting each composition weight portion is: 10 parts of Radix Pseudostellariaes, 12 parts of the Rhizoma Atractylodis Macrocephalaes, 8 parts, Poria, 8 parts of Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens)s, 5 parts of Fructus Evodiaes, 12 parts of Radix Bupleuri, 6 parts of Bullus Notholirionis Bulbuliferi, 12 parts of Fructus Akebiaes, 5 parts of Rhizoma Zingiberiss, 12 parts of Fructus Aurantii Immaturuss, 10 parts of Radix seu Cortex Machili bracteataes, 6 parts of Pericarpium Citri Reticulataes, husky 6 parts of Zijin, 9 parts of Cortex Magnoliae Officinalis, 8 parts of Radix Scutellariaes, 3 parts of Rhizoma Coptidis, 5 parts of Radix Hemsleyae Macrospermae, 12 parts of Endoconcha Sepiaes, 8 parts of Rhizoma Corydalis, 8 parts of Pseudobulbus Bletillae (Rhizoma Bletillae).
Embodiment 7:
The crude drug of getting each composition weight portion is: 14 parts of Radix Pseudostellariaes, 20 parts of the Rhizoma Atractylodis Macrocephalaes, 12 parts, Poria, 9 parts of Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens)s, 3 parts of Fructus Evodiaes, 9 parts of Radix Bupleuri, 5 parts of Bullus Notholirionis Bulbuliferi, 9 parts of Fructus Akebiaes, 3 parts of Rhizoma Zingiberiss, 10 parts of Fructus Aurantii Immaturuss, 12 parts of Radix seu Cortex Machili bracteataes, 9 parts of Pericarpium Citri Reticulataes, husky 9 parts of Zijin, 9 parts of Cortex Magnoliae Officinalis, 6 parts of Radix Scutellariaes, 5 parts of Rhizoma Coptidis, 8 parts of Radix Hemsleyae Macrospermae, 14 parts of Endoconcha Sepiaes, 10 parts of Rhizoma Corydalis, 10 parts of Pseudobulbus Bletillae (Rhizoma Bletillae).
Embodiment 8:
The crude drug of getting each composition weight portion is: 12 parts of Radix Pseudostellariaes, 10 parts of the Rhizoma Atractylodis Macrocephalaes, 10 parts, Poria, 8 parts of Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens)s, 4 parts of Fructus Evodiaes, 10 parts of Radix Bupleuri, 9 parts of Bullus Notholirionis Bulbuliferi, 12 parts of Fructus Akebiaes, 3 parts of Rhizoma Zingiberiss, 14 parts of Fructus Aurantii Immaturuss, 12 parts of Radix seu Cortex Machili bracteataes, 6 parts of Pericarpium Citri Reticulataes, husky 9 parts of Zijin, 8 parts of Cortex Magnoliae Officinalis, 6 parts of Radix Scutellariaes, 4 parts of Rhizoma Coptidis, 4 parts of Radix Hemsleyae Macrospermae, 12 parts of Endoconcha Sepiaes, 12 parts of Rhizoma Corydalis, 12 parts of Pseudobulbus Bletillae (Rhizoma Bletillae).
The present invention is described further by pharmacological testing, clinical observation test.
test example 1, the test of pesticide effectiveness
One, object: observe the therapeutical effect of we to experimental chronic gastritis rat.
Two, method: application fresh pig bile glycerol adding gavage copies rat chronic gastritis model.Rat model is divided into positive control SANJIU WEITAI group, this compositions group and this prescription prepared slices of Chinese crude drugs group, prior art matched group one (patent CN101332285A), prior art matched group two (patent CN102397516A) at random, gavage is respectively organized test liquid respectively, blank group and model group gavage equivalent distilled water, each organizes all continuously gavage 1 month; Observe rat body weight and gastric mucosa pathological histology and change, and detect rat stomach liquid measure, gastric acidity, pepsin activity and barrier mucus.Adopt mice caused by dimethylbenzene xylene ear swelling and acetic acid to cause mouse writhing reaction model, observe our antiinflammatory, analgesic activity.
Three, material
1, laboratory animal: SD rat, male and female half and half, body weight 18O~200g; Kunming kind female mice, body weight 18~22g.
2, medicine: press this compositions of the present embodiment 5 preparation superfine powder, prepare test liquid 16g/kg(and be equivalent to 5 times of people's consumption); By embodiment 5 prescription, take the prepared slices of Chinese crude drugs, make prepared slices of Chinese crude drugs group test liquid 16g/kg(and be equivalent to 5 times of people's consumption); By the Chinese medicine > > CN101332285A of a < < formula for treating gastropathy, prepare matched group one test liquid 10.5g/kg(and be equivalent to 5 times of people's consumption); Chinese medicine composition > > CN102397516A embodiment 1 method for the treatment of chronic gastritis by mono-kind of < < is prepared matched group two test liquid 0.36g/kg(and is equivalent to 5 times of people's consumption); SANJIU WEITAI KELI (Sanjiu Pharmaceutical Co., Ltd) 4g/kg(is equivalent to 5 times of people's consumption).
3, main pharmacological evaluation and result thereof
(1) impact rat body weight being changed
Model group rat is few compared with blank group body weight gain, and outward appearance fur lacks gloss, and movable minimizing, becomes thin.Each administration group rat body weight rate of increase increases compared with model group.Wherein this compositions group, prepared slices of Chinese crude drugs group, the increase of SANJIU WEITAI group extremely significantly (P < 0.01), matched group one increases significantly (P < 0.05), and matched group two increases there was no significant differences.
(2) gastric mucosa pathological histology is observed
1. perusal
Normal rat gastric mucosa pinkiness, surfacing is smooth, and coat of the stomach muscular tension is stronger.Model group gastric mucosa color is more shallow, and surface lacks gloss, and under gastric mucosa, blood vessel is easily shown in, coat of the stomach muscular tension is poor.Each administration group gastric mucosa color and coat of the stomach muscular tension are between between the two, and wherein this compositions group, prepared slices of Chinese crude drugs group, SANJIU WEITAI group more approach normal group.
2. om observation
Normal rats gastric epithelial is complete, without hyperemia, edema and erosion, has the body of gland of dense arrangement in lamina propria, and body of stomach is without obvious cell infiltration, and muscularis mucosae is thinner.Model group gastric mucosa is imperfect, mucosa attenuation or erosion, and body of stomach lamina propria endolymph cell and neutrophilic infiltration, muscularis mucosae thickens, and became uneven.Visible a small amount of lymphocyte, plasmocyte infiltrating in this combination object height group lamina propria, muscularis mucosae is thicker, compared with model group, has clear improvement, and is better than SANJIU WEITAI group; Prepared slices of Chinese crude drugs group, SANJIU WEITAI group mucosa thicken, visible a small amount of granulation tissue hyperplasia in lamina propria, and chronic inflammatory cell infiltrates less, compared with model group, is improved; Two groups of mucosa gland structures of matched group destroy obviously, and chronic inflammatory cell infiltrates more obvious, and muscularis mucosae obviously thickens; One group of matched group is between two groups of SANJIU WEITAI group and matched groups.Experimental result shows, this compositions group can obviously be improved the pathology damage of rat model gastric mucosa, and the gastric mucosa of atrophy is had to good repair, and matched group two repairs are not obvious.Wherein prepared slices of Chinese crude drugs group effect is suitable with SANJIU WEITAI group, but is better than matched group one, matched group two.
(3) gastric analysis
With model group comparison, this compositions group, prepared slices of Chinese crude drugs group, matched group one all obviously reduce with SANJIU WEITAI group gastric juice amount (P < 0.05), matched group two affects without significance gastric juice amount, points out this compositions to be conducive to promote model mice gastric juice to measure recovery normal level.Each administration group and model group rat stomach acidity there was no significant difference.Model group pepsin activity obviously reduces (P < 0.001) compared with blank group; With model group comparison, this compositions group, prepared slices of Chinese crude drugs group, matched group one and SANJIU WEITAI group pepsin activity significantly improve, compositions group difference extremely significantly (P < 0.01) wherein, matched group one, prepared slices of Chinese crude drugs group, the safe group of nine stomaches significant difference (P < 0.05), matched group two affects without significance.Model group barrier mucus obviously reduces (P < 0.001) compared with blank group, this compositions group, prepared slices of Chinese crude drugs group and matched group one barrier mucus increase obviously, wherein compositions group is compared with model group and SANJIU WEITAI group difference tool significance (P < 0.01) extremely, prepared slices of Chinese crude drugs group, matched group one are compared with model group and SANJIU WEITAI group difference tool significance (P < 0.05), matched group two there was no significant differences.The results are shown in Table 1.
Table 1 pair rat gastric juice analysis result ( )
Note: with the comparison of blank group, warp tcheck, * * p < 0.01, * * * p < 0.001; With model group △ P < 0.05, △ △ P < 0.01; With SANJIU WEITAI group #P < 0.05, ##P < 0.01
(4) anti-inflammatory and analgesic effect
1.the impact of xylol induced mice ear swelling
Adopt gastric infusion mode, this compositions dosage is 16g/kg, prepared slices of Chinese crude drugs group 16g/kg, matched group one 10.5g/kg, matched group two 0.36g/kg, positive controls gives SANJIU WEITAI 4g/kg, continuous use 3 days, blank group gives isopyknic normal saline.After last administration, 30min only drips in mouse right ear front-back with dimethylbenzene 0.05ml/.After lh, dislocation is put to death and to be cut ears, with 8mm belt puncher, mouse ear is laid to round auricle with position, accurately weighs, and the difference of same mice left and right auricle of take is swelling.The results are shown in Table 2.
Table 2 xylol induced mice ear swelling affect result of the test ( , n=10)
Group Sample number (only) Dosage (g/kg) Swelling
Blank group 10 / 19.4±5.8
This compositions group 10 16 13.5±4.3**
Prepared slices of Chinese crude drugs group 10 16 15.0±4.3*
Matched group one 10 10.5 16.9±3.6*
Matched group two 10 0.36 17.2±5.4
SANJIU WEITAI group 10 4 14.6±4.7*
Note: with the comparison of blank group, warp tcheck, * p< 0.05, * * p< 0.01.
As shown in Table 2, each administration group swelling is all less than blank group, wherein this compositions group and blank group have utmost point significant difference ( p< 0.01), prepared slices of Chinese crude drugs group, one group of matched group, SANJIU WEITAI group and blank group have significant difference ( p< 0.05), matched group two there was no significant differences.This compositions of experiment prompting has good antiinflammatory action, and prepared slices of Chinese crude drugs group is suitable with SANJIU WEITAI group, and matched group two does not present obvious antiinflammatory action.
2. the impact on thermostimulation induced pain due to hot plate method
Adopt gastric infusion mode, this compositions dosage is 16g/kg, prepared slices of Chinese crude drugs group 16g/kg, matched group one 10.5g/kg, matched group two 0.36g/kg, positive controls gives SANJIU WEITAI 4g/kg, continuous use 3 days, blank group gives isopyknic normal saline.Within 15,30,60 minutes after last administration, survey respectively mice pain threshold, for preventing scalding, setting deadline is 60 s.Calculate the threshold of pain and improve percentage rate.The results are shown in Table 3.
Table 3 on thermostimulation induced pain due to hot plate method affect result of the test ( , n=10)
Note: with the comparison of blank group, warp tcheck, * p< 0.05, * * p< 0.01, * * * p< 0.001.
As shown in Table 3, with the comparison of blank group, this compositions group, prepared slices of Chinese crude drugs group and SANJIU WEITAI group all can significantly improve pain threshold, have extremely significant difference ( p< 0.001).Matched group one when 60min compared with blank group difference tool extremely significance ( p< 0.001), matched group two there was no significant differences.This compositions of experiment prompting is good to the inhibitory action of thermostimulation induced pain, rapid-action, and effect is strong, and matched group one onset is slow, and matched group more than two is without effect.This compositions group, prepared slices of Chinese crude drugs group drug effect strengthen in time gradually simultaneously, and SANJIU WEITAI group is the strongest when administration 30min, during 60min, weakens to some extent.
4, test of pesticide effectiveness brief summary
Wherein this compositions group can significantly increase rat body weight, obviously improve rat model gastric mucosa color and coat of the stomach muscular tension, alleviate cell infiltration and mucosa pathology damage, the gastric mucosa of atrophy is had to good repair, significantly improve pepsin activity, drug effect is suitable with SANJIU WEITAI group.This compositions can obviously increase barrier mucus simultaneously, is better than SANJIU WEITAI group.Prepared slices of Chinese crude drugs group drug effect is weaker than this compositions group, but obviously than matched group one and matched group the last two.The every test index of matched group two is all not improved, may be little relevant with dosage.
test example 2, clinical observation on the therapeutic effect data
The treatment clinical method of chronic gastritis is a lot of, there is no definite curative effect.We adopted the present invention to treat one group of case in nearly 3 years, obtained good curative effect, and existing report is as follows:
1, clinical data
(1) physical data: this is tested 164 routine Patients with Chronic Gastritis and is my Out-patient Department patient, all patients all meet the diagnostic criteria of " gastric abscess " in the revision < < of State Administration of Traditional Chinese Medicine traditional Chinese medical science disease Standardization of diagnosis and curative effect > >, and patient is divided into two groups at random according to the odd or even number for the treatment of.
Treatment group 82 examples, male 48 examples wherein, female's 34 examples, patient age is between 23~74 years old; The course of disease was in 1~27 year.Matched group 82 examples, male 43 examples wherein, female's 39 examples, patient age is between 25~71 years old; The course of disease was in 1~22 year.
The no significant differences such as two groups of patients' sex, age, gastritis type and the course of disease, P > 0.05, has comparability.
(2) Therapeutic Method: matched group gives western medicine, comprises 2 times/d of omeprazole, each 20mg; 2 times/the d in amoxicillin, each 500mg; 3 times/d of metronidazole, each 0.2g; Treatment group be take invigorating the spleen and benefiting QI, warming middle-JIAO for easing the stomach, promoting the circulation of QI to relieve pain and is held concurrently heat clearing away as method for the treatment of, and directly oral or boiled water is taken after mixing it with water, and 1 dose of every day, minute sooner or later takes for 2 times.Prescription adjusts accordingly in following scope endogenous cause of ill symptom:
10-14 parts of Radix Pseudostellariaes, 10-20 parts of the Rhizoma Atractylodis Macrocephalaes, 10-20 parts, Poria, 8-12 parts of Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens)s, 1-5 parts of Fructus Evodiaes, 8-12 parts of Radix Bupleuri, 8-16 parts of Fructus Akebiaes, 2-6 parts of Rhizoma Zingiberiss, 10-20 parts of Fructus Aurantii Immaturuss, 6-10 parts of Pericarpium Citri Reticulataes, 6-10 parts of Cortex Magnoliae Officinalis, 8-12 parts of Radix Scutellariaes, 2-6 parts of Rhizoma Coptidis, 12-18 parts of Endoconcha Sepiaes, 9-15 parts of Rhizoma Corydalis, 12-18 parts of Pseudobulbus Bletillae (Rhizoma Bletillae).
Continuous use 2 months.
Two groups of patients all avoid and use raw and cold food during treating, and do not eat pungent irritable food, and regular diet, has more meals a day but less food at each, and chews carefully and swallow slowly, and give up tobacco and wine, fasting coffee, strong tea and overheated food.
(3) curative effect determinate standard: according to curative effect determinate standard evaluation in " diagnosis basis of gastric abscess, card marquis classification, efficacy evaluation " in the revision < < of State Administration of Traditional Chinese Medicine traditional Chinese medical science disease Standardization of diagnosis and curative effect > >.
1. cure: gastric abscess and other transference cure, x-ray canel barium meal contrast examination or gastroscopy are normal;
2. take a turn for the better: stomachache is alleviated, attack times reduces, and other symptoms alleviate, and x-ray canel barium meal contrast examination or gastroscopy take a favorable turn;
3. do not heal: symptom is without improvement, and x-ray canel barium meal contrast examination or gastroscopy are unchanged.
(4) statistical method: adopt tcheck and x 2check.
2, result
The comparison of two groups of patient clinical curative effects, cures 15 examples in treatment group 82 examples, 64 examples that take a turn for the better, and 3 examples that do not heal, total effective rate is 96.3%; In matched group 82 examples, cure 7 examples, 63 examples that take a turn for the better, 12 examples that do not heal, total effective rate 85.4 %.Epidemiological Analysis by statistics, treatment group and matched group on clinical efficacy, exist extremely significant difference ( p < 0.01).

Claims (6)

1. treat a Chinese medicine composition for chronic gastritis, it is characterized in that it is comprised of the crude drug of following weight portion: 10-14 parts of Radix Pseudostellariaes, 10-20 parts of the Rhizoma Atractylodis Macrocephalaes, 10-20 parts, Poria, 8-12 parts of Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens)s, 1-5 parts of Fructus Evodiaes, 8-12 parts of Radix Bupleuri, 8-16 parts of Fructus Akebiaes, 2-6 parts of Rhizoma Zingiberiss, 10-20 parts of Fructus Aurantii Immaturuss, 6-10 parts of Pericarpium Citri Reticulataes, 6-10 parts of Cortex Magnoliae Officinalis, 8-12 parts of Radix Scutellariaes, 2-6 parts of Rhizoma Coptidis, 12-18 parts of Endoconcha Sepiaes, 9-15 parts of Rhizoma Corydalis, 12-18 parts of Pseudobulbus Bletillae (Rhizoma Bletillae).
2. a kind of Chinese medicine composition for the treatment of chronic gastritis according to claim 1, is characterized in that the consumption of each crude drug is: 12 parts of Radix Pseudostellariaes, 15 parts of the Rhizoma Atractylodis Macrocephalaes, 15 parts, Poria, 10 parts of Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens)s, 3 parts of Fructus Evodiaes, 10 parts of Radix Bupleuri, 12 parts of Fructus Akebiaes, 4 parts of Rhizoma Zingiberiss, 15 parts of Fructus Aurantii Immaturuss, 8 parts of Pericarpium Citri Reticulataes, 8 parts of Cortex Magnoliae Officinalis, 10 parts of Radix Scutellariaes, 4 parts of Rhizoma Coptidis, 15 parts of Endoconcha Sepiaes, 12 parts of Rhizoma Corydalis, 15 parts of Pseudobulbus Bletillae (Rhizoma Bletillae).
3. treat a Chinese medicine composition for chronic gastritis, it is characterized in that it is comprised of the crude drug of following weight portion: 10-14 parts of Radix Pseudostellariaes, 10-20 parts of the Rhizoma Atractylodis Macrocephalaes, 6-12 parts, Poria, 3-9 parts of Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens)s, 1-5 parts of Fructus Evodiaes, 6-12 parts of Radix Bupleuri, 3-9 parts of Bullus Notholirionis Bulbuliferi, 6-12 parts of Fructus Akebiaes, 2-6 parts of Rhizoma Zingiberiss, 5-15 parts of Fructus Aurantii Immaturuss, 6-12 parts of Radix seu Cortex Machili bracteataes, 6-10 parts of Pericarpium Citri Reticulataes, 6-10 parts, Zijin sand, 6-10 parts of Cortex Magnoliae Officinalis, 3-9 parts of Radix Scutellariaes, 2-6 parts of Rhizoma Coptidis, 3-9 parts of Radix Hemsleyae Macrospermae, 12-18 parts of Endoconcha Sepiaes, 6-12 parts of Rhizoma Corydalis, 6-12 parts of Pseudobulbus Bletillae (Rhizoma Bletillae).
4. a kind of Chinese medicine composition for the treatment of chronic gastritis according to claim 3, is characterized in that the consumption of each crude drug is: 12 parts of Radix Pseudostellariaes, 15 parts of the Rhizoma Atractylodis Macrocephalaes, 9 parts, Poria, 6 parts of Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens)s, 3 parts of Fructus Evodiaes, 9 parts of Radix Bupleuri, 6 parts of Bullus Notholirionis Bulbuliferi, 9 parts of Fructus Akebiaes, 4 parts of Rhizoma Zingiberiss, 10 parts of Fructus Aurantii Immaturuss, 9 parts of Radix seu Cortex Machili bracteataes, 8 parts of Pericarpium Citri Reticulataes, husky 8 parts of Zijin, 8 parts of Cortex Magnoliae Officinalis, 6 parts of Radix Scutellariaes, 4 parts of Rhizoma Coptidis, 6 parts of Radix Hemsleyae Macrospermae, 15 parts of Endoconcha Sepiaes, 9 parts of Rhizoma Corydalis, 9 parts of Pseudobulbus Bletillae (Rhizoma Bletillae). ?
5. according to the arbitrary described a kind of Chinese medicine composition for the treatment of chronic gastritis of claim 1-4, it is characterized in that this Chinese medicine composition has following dosage form: powder, hard capsule, soft capsule, tablet, pill. ?
6. according to the arbitrary described a kind of preparation technology who treats the Chinese medicine composition of chronic gastritis of claim 1-4, it is characterized in that this preparation technology comprises the steps:
By the prepared slices of Chinese crude drugs of each crude drug, in 60 ℃ dry 12 hours, mixed powder is broken into coarse powder, then puts into super micron mill, is ground into 1~75 μ m superfine powder, obtains; Or get superfine powder and record capsule; Or get superfine powder and be pressed into tablet; Or get superfine powder and make pill.
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CN103316129B (en) * 2013-07-08 2015-07-29 王晓枫 A kind of Chinese medicine composition for the treatment of acute gastritis and preparation method thereof
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