CN106421554A - Traditional Chinese medicine preparation for treating tonsillitis - Google Patents
Traditional Chinese medicine preparation for treating tonsillitis Download PDFInfo
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- CN106421554A CN106421554A CN201610792847.7A CN201610792847A CN106421554A CN 106421554 A CN106421554 A CN 106421554A CN 201610792847 A CN201610792847 A CN 201610792847A CN 106421554 A CN106421554 A CN 106421554A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/19—Acanthaceae (Acanthus family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/90—Smilacaceae (Catbrier family), e.g. greenbrier or sarsaparilla
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Abstract
The invention discloses a traditional Chinese medicine preparation for treating tonsillitis, and belongs to the technical field of traditional Chinese medicine. By combining years of clinical treatment experience, according to pathogenesis of the tonsillitis and the theory of traditional Chinese medicine for diagnosis and treatment based on an overall analysis of the illness and the patient's condition, an applicant selects Blin's embelia roots, rhizomes of glabrous greenbrier, acanthus ilicifolius, bur beggarticks herb, herb of divaricate carpesium and rose-of-sharon roots to be prepared into a traditional Chinese medicine decoction. According to the clinical tests, the total effective rate reaches 100% which is obviously superior to that of a control group, and no side or toxic effect exists.
Description
Technical field
The present invention relates to technical field of traditional Chinese medicines, particularly relate to one and treat tonsillitic Chinese medicine preparation.
Content of the invention
Tonsillitis is amygdaline inflammation.Be divided into acute and chronic two kinds clinically, cardinal symptom be pharyngalgia, heating and
Pharyngeal sense of discomfort etc..This disease can cause the complication locally or systemically such as ear, nose and the heart, kidney, joint, therefore should pay attention to.Flat
Based on scorching pathogenic former of peach body is with hemolytic streptococcus, other are such as staphylococcus, pneumococcus, Bacillus influenzae and virus etc. also
Can cause.For the treatment of tonsil inflammation, currently mainly taking or injecting anti-inflammation drugs and carry out anti-inflammatory to it, severe patient is even
Need to carry out tonsil resection operation, and drug main Western medicine to be used, Western medicine side effect is big, is easily generated the resistance to the action of a drug, result for the treatment of
Not good, easily repeatedly, and surgery excision tonsillotome, it is easily destroyed the immunologic mechanism of body, bring a series of looking back to patient
Sorrow.Chinese pharmacology, as the traditional medicine of China, has advantages such as effect strong, instant effect, lasting medicine, and do not have dependence,
Drug resistance and toxic and side effect.Applicant, through clinical experience for many years, continuous exploratory development, develops one and treats tonsillotome
Scorching Chinese medicine preparation, is applied to clinic and achieves preferable result for the treatment of.
Content of the invention
It is an object of the invention to provide one and treat tonsillitic Chinese medicine preparation.The traditional Chinese medical science thinks that tonsillitis is many by wind-heat
Evil poison is invaded, caused by interior heat crosses Sheng, also can be pungent because of many foods, and taste intrinsic heat, heat poison is attacked, fights and send out in larynx core.Therefore in treatment
Preferably use wind and heat dispersing, the profit pharynx of cool blood, the method for detoxicating, relieving inflammation.
It is an object of the invention to be achieved through the following technical solutions, the tonsillitic Chinese medicine preparation of this treatment is by following heavy
The Chinese medicine of amount part is made：Laxflower embelia root 7-11 part, red Bi 15-25 part, mouse 10-14 part, bur beggar-ticks 8-12 part, gold are picked one's ears
10-16 part, shrubalthea root 4-8 part.
Preferably：Laxflower embelia root 9 parts, red Bi 20 parts, mouse 12 parts, bur beggar-ticks 10 parts, gold earpick 13 parts, shrubalthea root
6 parts.
Preparation method：Traditionally make decoction.
Fang Zhong：Laxflower embelia root eliminate the phlegm removing toxic substances, promoting circulation of blood detumescence；Red Bi dispels rheumatism, stranguria treating and diuresis inducing, eliminating inflammation and expelling toxin；Mouse
Scattered stasis detumescence, eliminating phlegm pain relieving；Bur beggar-ticks yin-nourishing benefit lung, clearing heat and detoxicating, cures mainly tracheitis, pulmonary tuberculosis, sphagitis, tonsillotome
Inflammation, dysentery, erysipelas, tinea sore；Gold clearing heat and detoxicating, the throat of earpick；Shrubalthea root is clearing heat and detoxicating, inducing diuresis and reducing edema.
Detailed description of the invention
Embodiment one：Weigh laxflower embelia root 7g, red Bi 15g, mouse 10g, bur beggar-ticks 8g, gold earpick 10g, the rose of Sharon
Root 4g, traditionally makes decoction.
Embodiment two：Weigh laxflower embelia root 9g, red Bi 20g, mouse 12g, bur beggar-ticks 10g, gold earpick 13g, wood
Rose of Sharon root 6g, traditionally makes decoction.
Embodiment three：Weigh laxflower embelia root 11g, red Bi 25g, mouse 14g, bur beggar-ticks 12g, gold earpick 16g, wood
Rose of Sharon root 8g, traditionally makes decoction.
Toxicity test
1st, animal used as test cleaning grade healthy SD female rats 80, weight (210 ± 5) g, it is used as chronic toxicity；
The female small white mouse in the healthy Kunming of cleaning grade 60, weight (28 ± 4) g, it is used as acute toxicological experiment.Feed with normal diet, general
Logical drinking-water.Room temperature controls in (24 ± 3) DEG C, humidity (51 ± 4) %, natural lighting.
2nd, acute toxicological experiment is according to (Chinese medicine, researches on natural drugs registration operation manuals), selects the healthy Kunming of cleaning grade
Female small white mouse 60, is randomly divided into 2 groups, Chinese drug-treated group and each 30 of blank group.Chinese drug-treated group is rolled over by adult normal's oral dose
It is counted as the dosage of small white mouse, gavage Chinese medicine every day 1 time.Blank group is given 1mL/20g weight 0.9% sodium chloride injection and is filled
Clothes.
3rd, long term toxicity test cleaning grade healthy SD female rats 80, is randomly divided into 4 groups, Normal group and Chinese medicine
Group little, in, heavy dose of each 20.Control group gives 1ml/20g weight 0.9% sodium chloride injection, Chinese drug-treated group little, in,
Heavy dose of group is the 5th, the 15th, 50 times that adult normal consumption is converted to rat dosage, is gastric infusion, every day 1 time, experimental period
It is 3 months.
4th, acute toxicity testing result small white mouse is without dead in being administered 7d, gives observation post administration mouse outward appearance, hair color, light
Pool is normal, and social action, reaction are all normal, ingests, drains normally.After 7d, artificial putting to death is dissected, and observes its heart, liver, spleen
Dirty, lungs, kidney, brain, ovary, uterus are showed no exception.Pathological examination：Single-minded Yihong of bush (HE) is dyeed, and Chinese drug-treated group is dirty
Device smooth surface, in order, cell size, form are normal in institutional framework arrangement, and endochylema, karyon dyeing are clear, with blank group
Comparing difference not statistically significant (P ＞ 0.05).
5th, chronic toxicity result Chinese drug-treated group little, in, the outward appearance of heavy dose of group and rats in normal control group, hair color,
Social action, excitant etc. and to surrounding environment, food, the equal not statistically significant of comparing difference (P ＞ 0.05) such as interest of water.
Increase (P ＜ 0.05) before the experiment of weight all relatively this group after 4 groups of rat experiments, but the equal nothing of weight comparing difference after 4 groups of experiments
Statistical significance (P ＞ 0.05), blood cytology index, blood biochemical analysis index, important organ coefficient ratio after 4 groups of rat experiments
Compared with the equal not statistically significant of difference (P ＞ 0.05).At 4 groups of rats, after death important organ row staining pathologic section checks, HE dyes.
In order, cell size, form are normal for the arrangement of Chinese drug-treated group Rats Organs and Tissues institutional framework, and endochylema, karyon dyeing are clear, with normal control
Group comparing difference not statistically significant (P ＞ 0.05).
6th, toxicity test shows, the tonsillitic Chinese medicine preparation for the treatment of of the present invention has no toxic reaction after being administered.
Clinical data
1st, this group of physical data case is the court out-patient 320 case, wherein male 190 cases, female 130 case；Age 19～
59 years old, the course of disease 5～34 months, average 18 ± 1.2 months；On the basis of patient knows the inside story and be voluntary, patient is divided into 8 groups by us；
Only take laxflower embelia root simple group be A group, only take red Bi simple group be B group, only to take mouse simple group be C
Group, only take bur beggar-ticks simple group and be D group, only take gold earpick simple group and be E group, only take shrubalthea root simple group and be
F group, take the present invention by embodiment two preparation group be treatment group, use routine treatment be control group.Each group in age, sex
Compare not statistically significant (P ＞ 0.05) etc. physical data, there is comparativity.
2nd, treatment method treatment group is taken and is treated by the medicament that embodiment of the present invention two prepares；Control group is taken
Folium isatidis mixture, by specification use, the person of being in a bad way follows the doctor's advice the meal with wine amount of adding；Weigh A, B, C, D, E each simple group respectively
Weight, traditionally makes the medicament with treatment group same volume and is treated, and each group one week is a course for the treatment of, and each group patient is equal
Carry out comparitive study after treating two courses for the treatment of.
3rd, Outcome measure：
Cure：Tonsillotome inflammation, swelling and the transference cure such as the heating being caused because of tonsil inflammation, pain, body
Immunocompetence recovers normal；Take a turn for the better：Above-mentioned symptom has been alleviated, and body immunity has recovered；Invalid：Symptom is unchanged.
4th, treatment results such as following table
| Group | Number of cases | Dose (g) | Cure | Take a turn for the better | Invalid | Side effect | Total effective rate (%) |
| A | 40 | 85 | 2 | 3 | 35 | 8 cases | 12.5 |
| B | 40 | 85 | 1 | 2 | 37 | 4 cases | 7.5 |
| C | 40 | 85 | 6 | 1 | 33 | 6 cases | 17.5 |
| D | 40 | 85 | 1 | 1 | 38 | 3 cases | 5.0 |
| E | 40 | 85 | 2 | 2 | 36 | 3 cases | 10.0 |
| F | 40 | 85 | 3 | 1 | 36 | 2 cases | 10.0 |
| Treatment group | 40 | 70 | 38 | 2 | 0 | 0 case | 100.0 |
| Control group | 40 | Convention amount | 22 | 11 | 7 | 0 case | 82.5 |
By the dose of each simple in upper table, do toxicity test by the above-mentioned method doing toxicity test respectively, tied by experiment
Fruit understands that each simple group is nontoxic level.By above clinical data, although treatment group takes less dose, but
Achieving preferable result for the treatment of, total effective rate is higher than each simple total effective rate sum, is also significantly better than control group, more gratifying
Be toxicity reduce, have no side effect appearance, it follows that each medicine under synergistic function to the side of beneficially human health
To development, clinic popularization and application.
When following up a case by regular visits to above patient, wherein treatment group has 6 case readmes " after taking the preparation of the present invention, not only flat
Peach body inflammation has obtained rehabilitation, and night sweat symptom might as well ".After obtaining this message, we suffer from different journey to 30 cases immediately
Degree night sweat patient, uses the Chinese medicine preparation that embodiment of the present invention two prepares, and every day, potion, divided the method sooner or later taken twice to add
With treatment, according to curative effect judging standard：Recovery from illness refers to that night sweat stops completely, and concomitant symptom disappears substantially, nothing recurrence in 1 year after drug withdrawal；
Effective finger night sweat stops substantially, and concomitant symptom has been alleviated, nothing recurrence in 6 months after drug withdrawal；Invalid finger night sweat and concomitant symptom are equal
Without improving.Result is in 30 case patients, and 18 cases of fully recovering (60%), effective 12 cases (40%), invalid 0 case, total effective rate is by recovery from illness
It is calculated as 100% with effective.It follows that take the Chinese medicine preparation of the present invention, not only treatment tonsillitis is evident in efficacy, and right
Night sweat has good result for the treatment of, clinic popularization and application.
Claims (2)
1. treat tonsillitic Chinese medicine preparation for one kind, it is characterised in that this Chinese medicine preparation is made up of the Chinese medicine of following weight portion：
Laxflower embelia root 7-11 part, red grass 15-25 part, mouse 10-14 part, bur beggar-ticks 8-12 part, gold earpick 10-16 part, shrubalthea root
4-8 part.
2. one as claimed in claim 1 treats tonsillitic Chinese medicine preparation, it is characterised in that this Chinese medicine preparation is by following
The Chinese medicine of weight portion is made：Laxflower embelia root 9 parts, red careless 20 parts, mouse 12 parts, bur beggar-ticks 10 parts, gold pick one's ears 13 parts, the rose of Sharon
Root 6 parts.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610792847.7A CN106421554A (en) | 2016-08-24 | 2016-08-24 | Traditional Chinese medicine preparation for treating tonsillitis |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610792847.7A CN106421554A (en) | 2016-08-24 | 2016-08-24 | Traditional Chinese medicine preparation for treating tonsillitis |
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| Publication Number | Publication Date |
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| CN106421554A true CN106421554A (en) | 2017-02-22 |
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ID=58163888
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| Application Number | Title | Priority Date | Filing Date |
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| CN201610792847.7A Withdrawn CN106421554A (en) | 2016-08-24 | 2016-08-24 | Traditional Chinese medicine preparation for treating tonsillitis |
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106334024A (en) * | 2016-08-24 | 2017-01-18 | 刘红 | Traditional Chinese medicine preparation for treating lower extremity thrombophlebitis |
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2016
- 2016-08-24 CN CN201610792847.7A patent/CN106421554A/en not_active Withdrawn
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106334024A (en) * | 2016-08-24 | 2017-01-18 | 刘红 | Traditional Chinese medicine preparation for treating lower extremity thrombophlebitis |
Non-Patent Citations (1)
| Title |
|---|
| 李文瑞等: "《中药别名辞典》", 30 September 1994, 中国科学技术出版社 * |
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Application publication date: 20170222 |
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| WW01 | Invention patent application withdrawn after publication |