CN105998843A - Traditional Chinese medicine preparation for treating recurring type dental ulcers - Google Patents
Traditional Chinese medicine preparation for treating recurring type dental ulcers Download PDFInfo
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- CN105998843A CN105998843A CN201610566124.5A CN201610566124A CN105998843A CN 105998843 A CN105998843 A CN 105998843A CN 201610566124 A CN201610566124 A CN 201610566124A CN 105998843 A CN105998843 A CN 105998843A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/85—Verbenaceae (Verbena family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/86—Violaceae (Violet family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/90—Smilacaceae (Catbrier family), e.g. greenbrier or sarsaparilla
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Abstract
The invention discloses a traditional Chinese medicine preparation for treating recurring type dental ulcers and belongs to the technical field of traditional Chinese medicines. Through clinical practice for many years, in accordance with a pathogenic mechanism of the recurring type dental ulcers, and according to a theory of determining the treatment based on differentiation of symptoms and signs through traditional Chinese medicines, an inventor selects traditional Chinese medicines having the efficacies of clearing heat, removing toxicity, promoting blood circulation and promoting diuresis, such as knotted flower phyla herbs, littleleaf sida herbs, common eulaliopsis juvenile rhizomes, globose phaenosperma herbs, Philippine violet herbs, kohlrabi leaves and scabrousstem greenbrier rhizomes, to make decoction. Clinical tests prove that the total effective rate achieves 100%, and the traditional Chinese medicine preparation is free from toxic and side effects, and also has a good treatment effect for patients suffering with skin sensibility.
Description
Technical field
The present invention relates to technical field of Chinese medicines, particularly relate to a kind of Chinese medicine preparation treating recurrent oral ulceration.
Background technology
Recurrent oral ulceration (recurrent aphthous ulcer, RAU) is also known as recurrent aphthous stomatitis, recurrence
Property aphtha, is a kind of oral keritonocytes that sickness rate is higher, and the situation such as common cold, dyspepsia, psychentonia all can be drawn
Play the generation of this disease.RAU is apt to occur in lip, cheek, lingual margin etc., and local has obvious pain scorching hot, hinders feed and speaks, to patient
Work, life and psychology all bring the biggest impact.This disease cause of disease is the brightest, may be with heredity, dysimmunity, malnutrition, sense
The factors such as dye, social mentality are relevant.Applicant obtains significant curative effect with treatment by Chinese herbs RAU.Primary disease disease damage is positioned at body surface more, and often
Recurrent exerbation, typically takes western medicine, and side effect is big, is easily generated drug resistance.Therefore the present inventor have developed one and treats recurrence
The Chinese medicine preparation of property oral ulcer, not only has preferable curative effect, and has no side effect.
Summary of the invention
It is an object of the invention to provide a kind of Chinese medicine preparation treating recurrent oral ulceration.Chinese medicine thinks that primary disease belongs to
The traditional Chinese medical science " aphtha ", " aphtha " category, primary disease occurs relevant with eating and drinking without temperance, fate alternation, the heart that its pathogenesis is mainly blamed, functions of spleen and stomach
Can be not normal, pyretic toxicity smoulders, and in burning hot inflammation, fumigates dispute and causes a disease.
It is an object of the invention to be achieved through the following technical solutions, this Chinese medicine preparation is by the Chinese medicine system of following weight
Become: Herba Phylae Samentosea 40-60 part, Herba Sidae alnifoliae 100-120 part, Rhizoma eulatiopsis binatae 30-40 part, Herba Phaenospermatis globosae 50-60 part, Herba Violae dissectae 12-20 part,
Folium Brassicae caulorapae 50-70 part, Rhizoma Smilacis Scobinicaulis 9-15 part.
Preferred: Herba Phylae Samentosea 50 parts, Herba Sidae alnifoliae 110 parts, Rhizoma eulatiopsis binatae 35 parts, Herba Phaenospermatis globosae 55 parts, Herba Violae dissectae 16 parts, Corm Brassicae caulorapae
60 parts of leaf, Rhizoma Smilacis Scobinicaulis 12 parts.
Compound method: traditionally make decoction.
Fang Zhong: Herba Phylae Samentosea removing blood stasis to promote tissue regeneration；Herba Sidae alnifoliae clearing away damp-heat, solution sore；Rhizoma eulatiopsis binatae circulation of qi promoting removing blood stasis；Herba Phaenospermatis globosae qi-restoratives is good for
Spleen, regulating menstruation by adjusting the flow of blood；Herba Violae dissectae heat-clearing and toxic substances removing, subduing inflammation；Folium Brassicae caulorapae clearing away heat and promoting diuresis, removing toxic substances hemostasis；Rhizoma Smilacis Scobinicaulis removes rheumatism, solution of invigorating blood circulation
Poison.
Detailed description of the invention
Embodiment one: weigh Herba Phylae Samentosea 40g, Herba Sidae alnifoliae 100g, Rhizoma eulatiopsis binatae 30g, Herba Phaenospermatis globosae 50g, Herba Violae dissectae 12g,
Folium Brassicae caulorapae 50g, Rhizoma Smilacis Scobinicaulis 9g, traditionally make decoction.
Embodiment two: weigh Herba Phylae Samentosea 50g, Herba Sidae alnifoliae 110g, Rhizoma eulatiopsis binatae 35g, Herba Phaenospermatis globosae 55g, Herba Violae dissectae 16g,
Folium Brassicae caulorapae 60g, Rhizoma Smilacis Scobinicaulis 12g, preparation method is with embodiment one.
Embodiment three: weigh Herba Phylae Samentosea 60g, Herba Sidae alnifoliae 120g, Rhizoma eulatiopsis binatae 40g, Herba Phaenospermatis globosae 60g, Herba Violae dissectae 20g,
Folium Brassicae caulorapae 70g, Rhizoma Smilacis Scobinicaulis 15g, preparation method is with embodiment one.
Toxicity test
1, laboratory animal cleaning grade healthy SD female rats 40, weight (200 ± 6) g, as chronic toxicity；
The female white mice in cleaning grade health Kunming 20, weight (20 ± 4) g, as acute toxicological experiment.Feed with normal diet, general
Logical drinking-water.Room temperature controls in (24 ± 4) DEG C, humidity (51 ± 10) %, natural lighting.
2, acute toxicological experiment is according to (Chinese medicine, researches on natural drugs registration service manual), selects cleaning grade health Kunming
Female little from Mus 20, it is randomly divided into 2 groups, Chinese drug-treated group and each 10 of blank group.Chinese drug-treated group is administered orally 8g/d by adult normal
(being equivalent to crude drug 160g) is converted to the dosage of white mice, gavages Chinese medicine every day 1 time.Being administered volume is 1mL/20g weight, little
Mus dosage is equivalent to crude drug amount 1.01g.Blank group is given 1mL/20g weight 0.9% sodium chloride injection and is gavaged.
3, long term toxicity test cleaning grade healthy SD female rats 40, is randomly divided into 4 groups, Normal group and Chinese medicine
Group little, in, heavy dose of each 10.Normal group gives 1ml/20g weight 0.9% sodium chloride injection, Chinese drug-treated group little,
In, heavy dose of group be the 5 of adult normal consumption, 10,30 times, i.e. 0.17g, 0.34g, 0.98g.It is gastric infusion.Every day 1
Secondary, experimental period is 3 months.
4, acute toxicity testing result white mice nothing in being administered 7d is dead, to observation post administration mice outward appearance, hair color, light
Pool is normal, and social behavior, reaction are all normal, ingests, drains normally.Manually put to death dissection after 7d, observe its heart, liver, spleen
Dirty, lungs, kidney, brain, ovary, uterus are showed no exception.Pathological examination: dyeing in single-minded Yihong of Lignum Sappan (HE), Chinese drug-treated group is dirty
Device smooth surface, in order, cell size, form are normal in organizational structure arrangement, and the dyeing of endochylema, karyon is clear, with blank group
Comparing difference not statistically significant (P ＞ 0.05).The present invention is treated recurrent oral ulceration by result of calculation display white mice
The maximal tolerance times of Chinese medicine preparation is 180 times of adult.
5, chronic toxicity result Chinese drug-treated group little, in, heavy dose of group and the outward appearance of rats in normal control group, hair color,
Social behavior, zest etc. and to surrounding, food, the equal not statistically significant of comparing difference (P ＞ 0.05) such as interest of water.
(P ＜ 0.05) is increased before the experiment of weight the most relatively this group after 4 groups of rat experiments, but the equal nothing of weight comparing difference after 4 groups of experiments
Statistical significance (P ＞ 0.05), blood cytology index, blood biochemical analysis index, important organ coefficient ratio after 4 groups of rat experiments
Compared with the equal not statistically significant of difference (P ＞ 0.05).At 4 groups of rats, after death important organ row staining pathologic section checks, HE dyes.
In order, cell size, form are normal for the arrangement of Chinese drug-treated group Rats Organs and Tissues organizational structure, and the dyeing of endochylema, karyon is clear, with normal control
Group comparing difference not statistically significant (P ＞ 0.05).
Toxicity test shows, the Chinese medicine preparation for the treatment of recurrent oral ulceration of the present invention has no that toxicity is anti-after being administered
Should.
Clinical data
1, physical data: choose in August, 2011 in JIUYUE ,-2014, connects subject Blood of Patients with Recurrent Oral 200 example,
The maleest 106 examples, female 94 example, age 23-60 year, average 39 years old.On the basis of patient knows the inside story and be voluntary, patient is divided into 9
Group, each group patient's physical data compares not statistically significant (P ＞ 0.05), has comparability.Only take Herba Phylae Samentosea single medicinal material
Group is A group, only take Herba Sidae alnifoliae single medicinal material group is B group, only take Rhizoma eulatiopsis binatae single medicinal material group is C group, only takes Herba Phaenospermatis globosae single
Medicine group be D group, only take Herba Violae dissectae single medicinal material group be E group, only to take Folium Brassicae caulorapae single medicinal material group be F group, only takes Rhizoma Smilacis Scobinicaulis list
Taste medicine group is G group, and taking invention formulation group is treatment group, is matched group by tradition western medicine treatment；Single medicinal material group patient
Being respectively 10 examples, treatment group and matched group patient are respectively 15 examples.
2, Therapeutic Method: treatment group takes the decoction made by embodiment of the present invention two；Weigh A group, B group, C respectively
Group, D group, E group, F group, the single medicinal material of G group, add suitable quantity of water, endure out and the treatment same amount of decoction of group same concentrations, respectively organize by
The decoction prepared divides to be taken for twice sooner or later；Matched group patient gives regular western medicine external used medicine and oral cavity cleaning treatment, gives
Patient's customary physiological saline is gargled, and oral cavity ulcer powder medicine is applied to patient's oral ulcer position, 2-3 time/d, and each group 7d is 1
The individual course for the treatment of.
3, efficacy determination: recovery from illness: after treatment 7d, patient's oral ulcer surface thoroughly heals, and does not affect patient and normally takes food；Aobvious
Effect: after treatment 10d, patient's oral ulcer area is obviously reduced, and pain substantially reduces, can influent stream food；It is invalid: after treatment 14d,
Patient's oral ulcer area is without being obviously reduced, and pain is not apparent from alleviating, and meal situation does not obtains and is effectively improved.
4, therapeutic outcome: after one course for the treatment of of oral ulcer patient treatment, the therapeutic effect for the treatment of group is significantly better than other groups,
Difference has statistical significance.
| Group | n | Recovery from illness | Effective | Invalid | Total effective rate (%) |
| Treatment group | 30 | 22 | 8 | 0 | 100.0 |
| Matched group | 30 | 14 | 6 | 10 | 66.7 |
| A group | 20 | 0 | 5 | 15 | 33.3 |
| B group | 20 | 1 | 4 | 15 | 33.3 |
| C group | 20 | 0 | 6 | 14 | 42.8 |
| D group | 20 | 1 | 3 | 16 | 25.0 |
| E group | 20 | 0 | 0 | 20 | 0 |
| F group | 20 | 0 | 3 | 17 | 17.6 |
| G group | 20 | 0 | 2 | 18 | 11.1 |
When treatment group patient is followed up a case by regular visits to, wherein there are 3 example patients to teach their another experience to us, take this
After the Chinese medicine preparation of invention, not only oral ulcer has obtained effective treatment, and the anaphylaxis often shown effect also disappears.
" after entering the woods, arising that skin allergy every time, play pimple, itches in pole to have 2 example patients to say；Since taking the present invention's
After Chinese medicine preparation, above phenomenon disappears ".Another 1 patient's readme " is eaten shrimp at ordinary times, during oxya chinensis, can be occurred in 10-20 minute
Itching bitterly, occur that red pimple, sensation skin have hotness subsequently, its pain is the most unbearably；After the Chinese medicine preparation taking the present invention, not only control
Get well oral ulcer, and, when they do not note again eating shrimp, during oxya chinensis, anaphylaxis does not occurs ".Obtain this information
After, we utilize the Chinese medicine preparation of the present invention to have allergies patient to treat 28 example autopaths and 40 examples immediately, and 28
Recovering normal after example autopath is for oral administration in 15-30 minute, 40 examples carried out allergic condition stimulation after having allergies patient for oral administration,
Anaphylaxis does not occurs；Following up a case by regular visits to 3 years, all there is not anaphylaxis in above patient.
It follows that take the Chinese medicine preparation of the present invention, not only evident in efficacy to treatment oral ulcer, and to skin mistake
Quick disease has elimination effect, clinic popularization and application.
Claims (2)
1. the Chinese medicine preparation treating recurrent oral ulceration, it is characterised in that this Chinese medicine preparation is by following weight portion
Medicine is made: Herba Phylae Samentosea 40-60 part, Herba Sidae alnifoliae 100-120 part, Rhizoma eulatiopsis binatae 30-40 part, Herba Phaenospermatis globosae 50-60 part, Herba Violae dissectae 12-
20 parts, Folium Brassicae caulorapae 50-70 part, Rhizoma Smilacis Scobinicaulis 9-15 part.
A kind of Chinese medicine preparation treating recurrent oral ulceration, it is characterised in that this Chinese medicine preparation
It is made up of the Chinese medicine of following weight portion: Herba Phylae Samentosea 50 parts, Herba Sidae alnifoliae 110 parts, Rhizoma eulatiopsis binatae 35 parts, Herba Phaenospermatis globosae 55 parts, furunculosis
Grass 16 parts, Folium Brassicae caulorapae 60 parts, Rhizoma Smilacis Scobinicaulis 12 parts.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610566124.5A CN105998843A (en) | 2016-07-09 | 2016-07-09 | Traditional Chinese medicine preparation for treating recurring type dental ulcers |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610566124.5A CN105998843A (en) | 2016-07-09 | 2016-07-09 | Traditional Chinese medicine preparation for treating recurring type dental ulcers |
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| Publication Number | Publication Date |
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| CN105998843A true CN105998843A (en) | 2016-10-12 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106177038A (en) * | 2016-07-30 | 2016-12-07 | 孟庆美 | A kind of Chinese medicine preparation treating recurrent oral ulceration |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104208189A (en) * | 2014-08-25 | 2014-12-17 | 孙大龙 | Traditional Chinese medicine preparation for treating recurrent oral ulceration |
| CN105362382A (en) * | 2015-12-08 | 2016-03-02 | 中国人民解放军第二军医大学 | Traditional Chinese medicine composition for treating recurrent oral ulcer and application thereof |
-
2016
- 2016-07-09 CN CN201610566124.5A patent/CN105998843A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104208189A (en) * | 2014-08-25 | 2014-12-17 | 孙大龙 | Traditional Chinese medicine preparation for treating recurrent oral ulceration |
| CN105362382A (en) * | 2015-12-08 | 2016-03-02 | 中国人民解放军第二军医大学 | Traditional Chinese medicine composition for treating recurrent oral ulcer and application thereof |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106177038A (en) * | 2016-07-30 | 2016-12-07 | 孟庆美 | A kind of Chinese medicine preparation treating recurrent oral ulceration |
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