CN106214863A - A kind of Chinese medicine preparation treating chronic pharyngitis - Google Patents
A kind of Chinese medicine preparation treating chronic pharyngitis Download PDFInfo
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- CN106214863A CN106214863A CN201610716777.7A CN201610716777A CN106214863A CN 106214863 A CN106214863 A CN 106214863A CN 201610716777 A CN201610716777 A CN 201610716777A CN 106214863 A CN106214863 A CN 106214863A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/87—Vitaceae or Ampelidaceae (Vine or Grape family), e.g. wine grapes, muscadine or peppervine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
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Abstract
The invention discloses a kind of Chinese medicine preparation treating chronic pharyngitis, belong to technical field of Chinese medicines.Applicant is in clinical practice for many years, the cause of disease produced according to chronic pharyngitis, select Chinese medicine Radix Picridis Japonicae, Herba Hippuridis Vulgaris, Herba Cissi Javanae, Herba Epilobii palustris, Herba Bidentis Bipinnate (Herba Bidentis Pilosae, Herba Bidentis Pilosae), Herba Veronicae javanicae, decocting becomes decoction, through clinical trial, the therapeutic effect of chronic pharyngitis is reached 100%, hence it is evident that be better than single medicinal material and matched group, show preferable synergistic function, particularly skin allergy is also had preferable therapeutic effect.
Description
Technical field
The present invention relates to technical field of Chinese medicines, particularly relate to a kind of Chinese medicine preparation treating chronic pharyngitis.
Background technology
Pharyngitis is pharyngeal mucosa, the inflammation of submucous tissue, is often a part for upper respiratory tract infection.Length according to the course of disease
The short difference with pathological change character, is divided into acute pharyngitis, the big class of chronic pharyngitis two.Wherein, chronic pharyngitis is that a kind of course of disease is sent out
Open up chronic inflammatory disease slowly, often with adjacent organs or systemic disease deposit, as sinusitis, proventriculus type remains or retention abscess,
Pharyngeal bursitis etc..Conscious pharyngeal discomfort, does, itches, swollen, and secretions is many and causalgia, easy to dry, has foreign body sensation, not out, gulp down no
Under, above symptom speak the most, after edible irritable food, tired or Changes in weather time increase the weight of.Breathe the most not smooth have different
Thing resistance shelves.Chronic pharyngitis is more common in adult, and child also may occur in which, General Symptoms is the most inconspicuous, based on local symptom.Mesh
Before, doctor trained in Western medicine many employings antibiotics, anti-inflammatory agent control microorganism infection and inflammation, or use iodine preparation, vitamin to improve symptom, or adopt
With interferon therapy, use the external treatment such as laser, radio frequency if desired, although foreign body in pharynx sense is made moderate progress, but because destroying
The reasons such as the glandular secretion of mucosa and scar contracture, often bring dry pharynx and make pharyngalgia increase the weight of, to radical cure chronic pharyngitis effect
The best, easy recurrent exerbation.We, according to theory of Chinese medical science, make full use of the Chinese herbal medicine resource of China's abundant, suit the remedy to the case, develop
A kind of Chinese medicine preparation treating chronic pharyngitis, and in clinical trial, obtained preferable therapeutic effect.
Summary of the invention
It is an object of the invention to provide a kind of Chinese medicine preparation treating chronic pharyngitis.The traditional Chinese medical science thinks that chronic pharyngitis with the deficiency of YIN is
This, the domination of pathogen is mark, and determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs in treatment, with Yin-nourishing and body fluid promoting, promoting the circulation of QI and reducing phlegm, heat-clearing and toxic substances removing, promoting blood circulation to remove blood stasis as the rule for the treatment of.
It is an object of the invention to be achieved through the following technical solutions, the Chinese medicine preparation of this treatment chronic pharyngitis is by following heavy
The Chinese medicine of amount part is made: Radix Picridis Japonicae 11-15 part, Herba Hippuridis Vulgaris 8-12 part, Herba Cissi Javanae 3-7 part, Herba Epilobii palustris 14-20 part, gold
Small cup silver plate 12-16 part, Herba Veronicae javanicae 9-15 part.
Preferred: Radix Picridis Japonicae 13 parts, Herba Hippuridis Vulgaris 10 parts, Herba Cissi Javanae 5 parts, Herba Epilobii palustris 17 parts, Herba Bidentis Bipinnate (Herba Bidentis Pilosae, Herba Bidentis Pilosae) 14 parts,
Herba Veronicae javanicae 12 parts.
Preparation method: traditionally make decoction.
Fang Zhong: Radix Picridis Japonicae eliminating fire and detoxication, stasis-dispelling and pain-killing；Herba Hippuridis Vulgaris clearing away heat and cooling blood, nutrient solution of promoting the production of body fluid；Herba Cissi Javanae dispelling wind solution
Poison, detumescence dissipating blood stasis, reunion of bone；Herba Epilobii palustris controls laryngopharynx swelling and pain, wind heat hoarseness, high heat are dropped；Herba Bidentis Bipinnate (Herba Bidentis Pilosae, Herba Bidentis Pilosae) relieving the exterior syndrome heat clearing away,
Removing toxic substances dissipating blood stasis；Herba Veronicae javanicae wind and heat eliminating, removing toxic substances and promoting subsidence of swelling.
Detailed description of the invention
Embodiment one: weigh Radix Picridis Japonicae 11g, Herba Hippuridis Vulgaris 8g, Herba Cissi Javanae 3g, Herba Epilobii palustris 14g, Herba Bidentis Bipinnate (Herba Bidentis Pilosae, Herba Bidentis Pilosae)
12g, Herba Veronicae javanicae 9g, traditionally make decoction.
Embodiment two: weigh Radix Picridis Japonicae 13g, Herba Hippuridis Vulgaris 10g, Herba Cissi Javanae 5g, Herba Epilobii palustris 17g, Herba Bidentis Bipinnate (Herba Bidentis Pilosae, Herba Bidentis Pilosae)
14g, Herba Veronicae javanicae 12g, traditionally make decoction.
Embodiment three: weigh Radix Picridis Japonicae 15g, Herba Hippuridis Vulgaris 12g, Herba Cissi Javanae 7g, Herba Epilobii palustris 20g, Herba Bidentis Bipinnate (Herba Bidentis Pilosae, Herba Bidentis Pilosae)
16g, Herba Veronicae javanicae 15g, traditionally make decoction.
Toxicity test
1, laboratory animal cleaning grade healthy SD female rats 40, weight (200 ± 5) g, as chronic toxicity；
The female white mice in cleaning grade health Kunming 30, weight (27 ± 2) g, as acute toxicological experiment.Feed with normal diet, general
Logical drinking-water.Room temperature controls in (23 ± 3) DEG C, humidity (50 ± 2) %, natural lighting.
2, acute toxicological experiment is according to (Chinese medicine, researches on natural drugs registration service manual), selects cleaning grade health Kunming
Female white mice 30, is randomly divided into 2 groups, Chinese drug-treated group and each 15 of blank group.Chinese drug-treated group is by the oral conversion of adult normal
Become the dosage of white mice, gavage Chinese medicine every day 1 time.Blank group is given 1mL/20g weight 0.9% sodium chloride injection and is filled
Clothes.
3, long term toxicity test cleaning grade healthy SD female rats 40, is randomly divided into 4 groups, Normal group and Chinese medicine
Group little, in, heavy dose of each 10.Matched group gives 1ml/20g weight 0.9% sodium chloride injection, Chinese drug-treated group little, in,
Heavy dose of group is that adult normal consumption is converted to the 5 of rat dosage, 15,50 times, is gastric infusion, every day 1 time, experimental period
It it is 3 months.
4, acute toxicity testing result white mice nothing in being administered 7d is dead, to observation post administration mice outward appearance, hair color, light
Pool is normal, and social behavior, reaction are all normal, ingests, drains normally.Manually put to death dissection after 7d, observe its heart, liver, spleen
Dirty, lungs, kidney, brain, ovary, uterus are showed no exception.Pathological examination: dyeing in single-minded Yihong of Lignum Sappan (HE), Chinese drug-treated group is dirty
Device smooth surface, in order, cell size, form are normal in organizational structure arrangement, and the dyeing of endochylema, karyon is clear, with blank group
Comparing difference not statistically significant (P ＞ 0.05).
5, chronic toxicity result Chinese drug-treated group little, in, heavy dose of group and the outward appearance of rats in normal control group, hair color,
Social behavior, zest etc. and to surrounding, food, the equal not statistically significant of comparing difference (P ＞ 0.05) such as interest of water.
(P ＜ 0.05) is increased before the experiment of weight the most relatively this group after 4 groups of rat experiments, but the equal nothing of weight comparing difference after 4 groups of experiments
Statistical significance (P ＞ 0.05), blood cytology index, blood biochemical analysis index, important organ coefficient ratio after 4 groups of rat experiments
Compared with the equal not statistically significant of difference (P ＞ 0.05).At 4 groups of rats, after death important organ row staining pathologic section checks, HE dyes.
In order, cell size, form are normal for the arrangement of Chinese drug-treated group Rats Organs and Tissues organizational structure, and the dyeing of endochylema, karyon is clear, with normal control
Group comparing difference not statistically significant (P ＞ 0.05).
6, toxicity test shows, the Chinese medicine preparation of the treatment chronic pharyngitis of the present invention has no toxic reaction after being administered.
Clinical data
1, physical data is originally organized 240 examples and is my Out-patient Department patient, male 125 examples, female 115 example, age 19～58 years old, puts down
Equal 35 years old；The course of disease 3 months～5 years, average 29 months；On the basis of patient knows the inside story and be voluntary, patient is divided into 7 groups by us；
Only take Radix Picridis Japonicae single medicinal material group be A group, only take Herba Hippuridis Vulgaris single medicinal material group be B group, only to take Herba Cissi Javanae single medicinal material group be C
Group, only take Herba Epilobii palustris single medicinal material group and be D group, only take Herba Bidentis Bipinnate (Herba Bidentis Pilosae, Herba Bidentis Pilosae) single medicinal material group and be E group, only take Herba Veronicae javanicae list
Taste medicine group is F group, take the present invention by embodiment two preparation group be treatment group, employing routine treatment be matched group.Each group
The physical data such as age, sex compares not statistically significant (P ＞ 0.05), has comparability.
2, diagnostic criteria meets the diagnostic criteria of chronic pharyngitis, and gets rid of the concealment sexually transmitted disease (STD) of nose, pharynx, larynx, esophagus and cervical region
Become and mental sickness etc..
3, Therapeutic Method treatment group is taken and is treated by the prepared medicament of embodiment of the present invention two；Matched group is taken
Each 3 of QINGRE XIAOYANNING JIAONANG, 3 times/d；Weigh the weight of A, B, C, D, E each single medicinal material group respectively, traditionally make
Being treated with the medicament for the treatment of group same volume, each group one week is a course for the treatment of, and each group patient is carried out after all treating two courses for the treatment of
Comparitive study.
4, criterion of therapeutical effect (1) recovery from illness: pharyngalgia, be dried and foreign body sensation symptom is wholly absent, pharyngeal mucosa recovers normal；(2)
Effective: pharyngalgia, be dried and foreign body sensation symptom substantially disappear, pharyngeal mucosa acute congestion disappears；(3) invalid: above-mentioned symptom is without changing
Become, pharyngeal still congested.
5, therapeutic outcome such as following table
| Group | Number of cases | Dose (g) | Recovery from illness | Effective | Invalid | Side effect | Total effective rate (%) |
| A | 30 | 95 | 2 | 2 | 26 | 5 examples | 13.3 |
| B | 30 | 90 | 1 | 2 | 27 | 4 examples | 10.0 |
| C | 30 | 95 | 3 | 1 | 26 | 6 examples | 13.3 |
| D | 30 | 95 | 2 | 3 | 25 | 3 examples | 16.7 |
| E | 30 | 100 | 2 | 2 | 26 | 3 examples | 13.3 |
| F | 30 | 88 | 3 | 3 | 24 | 2 examples | 20.0 |
| Treatment group | 30 | 71 | 27 | 3 | 0 | 0 example | 100.0 |
| Matched group | 30 | Convention amount | 17 | 8 | 5 | 0 example | 83.3 |
By the dose of single medicinal material each in upper table, do toxicity test by the above-mentioned method doing toxicity test respectively, experiment tie
Fruit understands each single medicinal material group and is nontoxic level.By above clinical data, although treatment group takes less dose, but
Achieving preferable therapeutic effect, total effective rate is higher than each single medicinal material total effective rate sum, also significantly better than matched group, more gratifying
Be toxicity reduce, have no side effect appearance, it follows that each medicine under synergistic function to the side of beneficially human health
To development, clinic popularization and application.
When treatment group patient is followed up a case by regular visits to by applicant, 5 example patients are wherein had to teach their another experience to us,
After taking the Chinese medicine preparation of the present invention, not only chronic pharyngitis has obtained effective treatment, and the anaphylaxis often shown effect is also
Disappear." after entering the woods, arising that skin allergy every time, play pimple, itches in pole to have 2 example patients to say；Since taking this
After the Chinese medicine preparation of invention, above phenomenon disappears ".Another 3 patient's readmes " eat shrimp at ordinary times, during oxya chinensis, can be at 10-20 minute
Pain of itching inside occur, occur that red pimple, sensation skin have hotness subsequently, its pain is unbearably；After the Chinese medicine preparation taking the present invention,
Not only cure chronic pharyngitis, and, when they do not note again eating shrimp, during oxya chinensis, anaphylaxis does not occurs ".Obtain this
After one information, we utilize the Chinese medicine preparation of the present invention to have allergies patient to control 28 example autopaths and 28 examples immediately
Treating, 28 example autopaths recover normal after taking medicine in 15-30 minute, 28 examples had allergies patient to carry out allergic condition after taking medicine
Stimulate, anaphylaxis does not occurs；Following up a case by regular visits to 3 years, all there is not anaphylaxis in above patient.
It follows that take the Chinese medicine preparation of the present invention, not only evident in efficacy to treatment chronic pharyngitis, and to skin mistake
Quick disease has elimination effect, clinic popularization and application.
Claims (2)
1. the Chinese medicine preparation treating chronic pharyngitis, it is characterised in that this Chinese medicine preparation is made up of the Chinese medicine of following weight portion:
Radix Picridis Japonicae 11-15 part, Herba Hippuridis Vulgaris 8-12 part, Herba Cissi Javanae 3-7 part, Herba Epilobii palustris 14-20 part, Herba Bidentis Bipinnate (Herba Bidentis Pilosae, Herba Bidentis Pilosae) 12-16 part, little
Relieve inflammation or internal heat grass 9-15 part.
A kind of Chinese medicine preparation treating chronic pharyngitis, it is characterised in that this Chinese medicine preparation is by following
The Chinese medicine of weight portion is made: Radix Picridis Japonicae 13 parts, Herba Hippuridis Vulgaris 10 parts, Herba Cissi Javanae 5 parts, Herba Epilobii palustris 17 parts, Herba Bidentis Bipinnate (Herba Bidentis Pilosae, Herba Bidentis Pilosae) 14
Part, Herba Veronicae javanicae 12 parts.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201610716777.7A CN106214863A (en) | 2016-08-15 | 2016-08-15 | A kind of Chinese medicine preparation treating chronic pharyngitis |
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| CN201610716777.7A CN106214863A (en) | 2016-08-15 | 2016-08-15 | A kind of Chinese medicine preparation treating chronic pharyngitis |
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| CN201610716777.7A Withdrawn CN106214863A (en) | 2016-08-15 | 2016-08-15 | A kind of Chinese medicine preparation treating chronic pharyngitis |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101181393A (en) * | 2007-11-22 | 2008-05-21 | 张树球 | Chinese medicine preparation for curing common cold and producing method thereof |
| CN103961549A (en) * | 2014-05-17 | 2014-08-06 | 刘群 | Traditional Chinese medicinal composition for treating infant suppurative tonsillitis |
| CN104225405A (en) * | 2014-10-04 | 2014-12-24 | 王子乐 | Chinese medicinal buccal tablet for treating respiratory tract infection and preparation method |
| CN105535551A (en) * | 2016-02-15 | 2016-05-04 | 葛传芳 | Traditional Chinese medicine for treating amygdalitis |
-
2016
- 2016-08-15 CN CN201610716777.7A patent/CN106214863A/en not_active Withdrawn
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101181393A (en) * | 2007-11-22 | 2008-05-21 | 张树球 | Chinese medicine preparation for curing common cold and producing method thereof |
| CN103961549A (en) * | 2014-05-17 | 2014-08-06 | 刘群 | Traditional Chinese medicinal composition for treating infant suppurative tonsillitis |
| CN104225405A (en) * | 2014-10-04 | 2014-12-24 | 王子乐 | Chinese medicinal buccal tablet for treating respiratory tract infection and preparation method |
| CN105535551A (en) * | 2016-02-15 | 2016-05-04 | 葛传芳 | Traditional Chinese medicine for treating amygdalitis |
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Application publication date: 20161214 |