CN104958727A - Traditional Chinese medicine composition for treating pediatric asthma in paracmasia and application of traditional Chinese medicine composition - Google Patents

Abstract

The invention relates to traditional Chinese medicine composition for treating pediatric asthma in paracmasia. The traditional Chinese medicine composition is prepared by the following APIs(Active Pharmaceutical Ingredients) in parts by weight: 4-8 parts of semen brassicae, 4-8 parts of rhizoma corydalis, 2-4 parts of angelica dahurica, 2-4 parts of euphorbia kansui, 2-4 parts of asarum sieboldii, 2-20 parts of fresh ginger, 2-20 parts of syzygium aromaticum and 2-20 parts of cinnamomum cassia. The invention also relates to the application of the traditional Chinese medicine composition for treating the pediatric asthma in paracmasia. The traditional Chinese medicine composition disclosed by the invention has the advantages that 1, the preparation technology is simple, the total effective rate is high, and the use is convenient; 2, the blood serum EOS level can be reduced, the chronic inflammation in bronchus can be relived, and the occurrence and the development of asthma can be effectively reduced; 3, the lung function index of a children patient can be improved, resistance in an airway of the children patient can be reduced, and the asthma attacking degree can be reduced; 4, the syndrome integral of the children patient can be reduced, the asthma attacking frequency can be reduced, the living quality of the children patient can be obviously improved, and certain function for regulating biased constitution of the children patient can be obtained; 5, no wound can be generated, no toxic and side effects are generated, the asthma attacking can be delayed, the attacking degree can be relieved, and the living quality of the patient can be increased.

Description

One treats the paracmastic Chinese medicine composition of childhood asthma and application thereof

Technical field

The present invention relates to technical field of Chinese medicines, specifically, is that one treats the paracmastic Chinese medicine composition of childhood asthma and application thereof.

Background technology

Bronchial asthma (bronchial asthma) is the chronic airway inflammation illness jointly participated in by various kinds of cell (as acidophil, mastocyte, T lymphocyte, neutrophilic granulocyte and human airway epithelial cells etc.) and cellular component.In recent years, the sickness rate of bronchial asthma worldwide has the trend risen year by year, and developed country is higher than developing country, and higher than rural area, and there is obvious genetic predisposition in city.Chinese children asthma cooperative groups is in nineteen ninety and 2000 twice tissue whole nation childhood asthma prevalence Epidemiological study, and result shows, and the average prevalence of childhood asthma rises to 1.54% by 0.91%, on average rises 64.84% between 10 years.Find in the whole nation investigation of third time to 400,000 children in 2010 0-14 year childhood asthma prevalence reach 3.01%, comparatively within 2000, add 50%.Asthma have a strong impact on infant able-bodied while also bring huge financial burden and stress to the head of a family.

The treatment of doctor trained in Western medicine to bronchial asthma is divided into acute attack stage and catabasis.Stage of attack, drug main will play rapid recovery effect, as long acting β_2 agonistics, glucocorticoid, theophylline corrosion inhibiter, antihistamine drug, leukotrienes regulator and sodium cromoglicate etc.Catabasis drug main will play long-term control effect, as fugitive broxaterol, glucocorticoid, leukotrienes regulator, theophylline and anticholinergic agents etc.The treatment of Western medicine to asthma achieves very large effect, but the state of an illness easily repeatedly and the course for the treatment of long, and intestinal untoward reaction and the attached effect of Amplatzer duct occluder etc. can be produced.External treatment of Chinese medicine is all evident in efficacy to each phase treatment of asthma.Theory of Chinese medical science is thought " sick control ", for the traditional Chinese medical science to Asthma in Remission Stage prevention, alleviate asthma attack and provide theoretical foundation.Qing Dynasty doctor Zhang Lu is theoretical according to " treating winter disease in summer ", " taking good care of YANG in spring and summer ", initiative plastering therapy in dog days treatment asthma, record in " Zhang Shi doctor is logical ", dog days, Semen Sinapis Albae, Rhizoma Corydalis, Radix Kansui, Herba Asari, Moschus are adjusted in Sucus Zingberis, be applied to indwelling certain hour on acupuncture point, can make " old complaint is gone ".

The current traditional Chinese medical science is also proposed that multiple treatment children with asthma is paracmastic applies ointment or plaster, such as, Chinese patent literature 201410265894.7, disclosed in 2014 days for announcing JIUYUE 17 days, a kind of external application compound medicine being used for the treatment of catabasis of bronchitis asthma and its preparation method and application, is that raw material is made by the prepared slices of Chinese crude drugs of following parts by weight: Semen Sinapis Albae 6-12 part, Herba Asari 1-3 part, Rhizoma Arisaematis (processed) 6-12 part, Radix Kansui (processed) 2-5 part, Rhizoma Corydalis 6-12 part, Lignum Aquilariae Resinatum 3-6 part, Cortex Cinnamomi 3-6 part, Fructus Psoraleae 6-12 part; Preparation method: (1) medicine mixes, oven drying at low temperature, pulverizes, and crosses 60-100 mesh sieve; (2) CMC solution is prepared; (3) glycerol, nipagin ester, azone is added; (4) medicated powder mastic is mixed with in 1:3 ratio; (5) heat, non-woven fabrics bag, stripping and slicing.Chinese patent literature 201210003421.0, disclose a kind of outer plaster of Chinese medicinal magneto-therapy for the treatment of asthma of applying ointment or plaster for human acupoint July 4 2012 day for announcing, comprise: Semen Sinapis Albae 10-30, Rhizoma Corydalis 10-30, Radix Kansui 10-20, moxibustion Herba Asari 10-20, moxibustion Herba Ephedrae 5-15, Rhizoma Pinelliae 5-15, Radix Glycyrrhizae Preparata 5-10, Radix Stemonae (parched) 10-20, Cortex Cinnamomi 5-10, Semen Lepidii (Semen Descurainiae) 5-10, Sucus Zingberis 60-80, moxibustion Fructus Gleditsia 10-15, Moschus 1-1.5, Arisaema Cum Bile 10-15, Bulbus Fritillariae Cirrhosae 10 ~ 20, Pheretima 10 ~ 20, Borneolum Syntheticum 1 ~ 5, Semen Armeniacae Amarum 10 ~ 20, Rhizoma Cynanchi Stauntonii 10 ~ 20, honey-fried FLOS FARFARAE 10 ~ 20.Foregoing invention has certain curative effect for Asthma in Remission Stage, but these medicines still exist flavour of a drug are many, complicated process of preparation, therapeutic effect are not good enough shortcoming.Therefore, need that a kind of flavour of a drug are less, raw material is easy to get badly, the simple and obvious medicine of therapeutic effect of preparation technology, and this kind of medicine have not been reported.

Summary of the invention

The object of the invention is for deficiency of the prior art, provide one to treat the paracmastic Chinese medicine composition of childhood asthma.

Of the present invention again one object be that the purposes of above-mentioned Chinese medicine composition is provided.

Another object of the present invention is, provides above-mentioned Chinese medicine composition for the preparation of the preparation method of applying ointment or plaster.

For achieving the above object, the technical scheme that the present invention takes is:

One treats the paracmastic Chinese medicine composition of childhood asthma, it is characterized in that, it is made up of the crude drug of following weight portion: Semen Sinapis Albae 4-8 part, Rhizoma Corydalis 4-8 part, Radix Angelicae Dahuricae 2-4 part, Radix Kansui 2-4 part, Herba Asari 2-4 part, Rhizoma Zingiberis Recens 2-20 part, Flos Caryophylli 2-20 part, Cortex Cinnamomi 2-20 part.

Described Chinese medicine composition is made up of the crude drug of following weight portion: Semen Sinapis Albae 5-7 part, Rhizoma Corydalis 5-7 part, the Radix Angelicae Dahuricae 3 parts, Radix Kansui 3 parts, Herba Asari 3 parts, Rhizoma Zingiberis Recens 2-10 part, Flos Caryophylli 2-10 part, Cortex Cinnamomi 2-10 part.

Described Chinese medicine composition is made up of the crude drug of following weight portion: Semen Sinapis Albae 6 parts, Rhizoma Corydalis 6 parts, the Radix Angelicae Dahuricae 3 parts, Radix Kansui 3 parts, Herba Asari 3 parts, Rhizoma Zingiberis Recens 2-10 part, Flos Caryophylli 2-10 part, Cortex Cinnamomi 2-10 part.

Described Chinese medicine composition is made up of the crude drug of following weight portion: Semen Sinapis Albae 6 parts, Rhizoma Corydalis 6 parts, the Radix Angelicae Dahuricae 3 parts, Radix Kansui 3 parts, Herba Asari 3 parts, 10 parts, Rhizoma Zingiberis Recens, Flos Caryophylli 10 parts, Cortex Cinnamomi 10 parts.

For realizing above-mentioned second object, the technical scheme that the present invention takes is:

As above the application of arbitrary described Chinese medicine composition in the paracmastic medicine of preparation treatment childhood asthma.

Described medicine, for reducing childhood asthma catabasis patients serum EOS level, reduces inflammatory cell infiltration in air flue, alleviates chronic inflammatory disease in bronchus.

State medicine for reducing childhood asthma catabasis Pulmonary Function index, reduce air flue internal resistance, improve pulmonary ventilation function.Described lung function index is PEF value.

Described medicine medicament be apply ointment or plaster.

Described is applied to noon in dog days by ion-introduction therapy in patient's bilateral Dingchuan, feishu, region below the heart Acupoint Application in Treating.

For realizing above-mentioned 3rd object, the technical scheme that the present invention takes is:

The preparation method of applying ointment or plaster as above, comprises the steps:

A) weigh medicine by weight, Semen Sinapis, Rhizoma Corydalis, the Radix Angelicae Dahuricae, Radix Kansui, Herba Asari are ground to form medicated powder;

B) by ginger crush, the medicated powder Sucus Zingberis in step a is modulated into pasty state and does patent medicine cake;

C) Flos Caryophylli, Cortex Cinnamomi are ground to form medicated powder, be spread on medicine cake and skin contact; Described Flos Caryophylli, Cortex Cinnamomi mass ratio are 1:1.

Semen Sinapis Albae: the property of medicine is pungent, temperature.Attach to the lung and stomach meridians, effect warming the lung for resolving phlegm, promoting the circulation of QI eliminating stagnation, removing obstruction in the collateral to relieve pain.Be used for the treatment of cold-phlegm and stop up lung, cough with asthma is uncomfortable in chest, carbuncle of yin nature multiple abscess, the card such as numb limbs and tense tendons, arthralgia.Compendium of Material Medica calls it, and " promoting the circulation of QI eliminating phlegm, removes in cold warming up, loose swollen pain relieving.Control and breathe heavily regurgitation of coughing, numbness wood beriberi, muscles and bones waist saves all pains." " medicineization justice ": " Semen Sinapis Albae ... walk crosswise very prompt ... current very sharp, special relieving accumulation of pathogens expectorant, expectorant belongs to hot person and can separate, and belonging to cold person can fall apart.Expectorant is outside flesh side film, and non-this does not reach, and coerces at extremity two, and non-this is obstructed ..., sincere promoting the circulation of QI the chest stuffiness relieving god agent." Semen Sinapis Albae curative effect is accurate rapidly, eliminating phlegm the chest stuffiness relieving is warming the lung simultaneously, is our monarch drug.

Rhizoma Corydalis: the property of medicine is pungent, bitter, temperature.GUIXIN, liver, spleen channel.The pain relieving of effect blood-activating and qi-promoting.Compendium of Material Medica: " Rhizoma Corydalis, the stagnation of QI in energy promoting the circulation of blood, stasis in gas, therefore specially control upper and lower all pains all over the body, among using, simply fantastic.Lid Rhizoma Corydalis is invigorated blood circulation activating QI, and the first product medicine also." " Thunder God bubble moxibustion opinion ": " pained for extremely, speed looks for Rhizoma Corydalis." Rhizoma Corydalis not only enters gas but also enter blood, can control altogether by blood system edema caused by disorder of QI, be effect of monarch drug, the pain relieving of row warming spleen and stomach for dispelling cold with Semen Sinapis Albae altogether.

The Radix Angelicae Dahuricae: the property of medicine is pungent, temperature.Return lung, spleen, stomach warp.Effect expelling wind and cold, understand things pain-stopping.Be used for the treatment of cold, headache, toothache, nasal sinusitis, rheumatic arthralgia etc.Compendium of Material Medica is said: " control nasal sinusitis, epistaxis, toothache, supraorbital bone pain, large intestine constipation due to pathogenic wind, bleeding urine, married woman's blood dizziness due to wind pathogen is transported, and regurgitation of food from the stomach tells food; Solution arsenic poison, snakebite, cutter arrow incised wound." " the southern regions of the Yunnan Province book on Chinese herbal medicine " say: " wind of skin migration of dispelling, the only cold pain of the cold stomachache of stomach, whole body cold-damp pain." Radix Angelicae Dahuricae is that the capable pungent temperature cold expelling effect of monarch drug assisted by ministerial drug.

Radix Kansui: the property of medicine is bitter, cold; Poisonous.Return lung, kidney, large intestine channel.Effect sluices by drink, dispersing swelling and dissipating binds.Be used for the treatment of edema, tympanites, the breast side of body stops drink, wind-phlegm epilepsy, sore and toxic." pearl sac " is said: " through part that hydro-thermal is tied is the panacea of sluicing.In accumulation of fluid in the chest, non-this can not remove, therefore Zhong Jing Daxianxiong Tang uses it." " medicine mirror " say: " and specially in Hang Shui, the water that can go directly knot part ... if stay expectorant prolonged fluid-retention dyspepsia, Disorder heavily fortified point gathers, can be by ... therefore be apt to control ... expectorant against epilepsy, dysphagic painful abdominal mass plug." Radix Kansui is that minister assists monarch drug expelling fluid-retention, dissipation expectorant is evil.

Herba Asari: the property of medicine is pungent, warm, slightly poisonous, enters lung, kidney, heart channel.Effect is induced sweat cold expelling, and wind-expelling pain-stopping is sensible, warming the lung to resolve fluid-retention.Compendium of Material Medica cloud: " Herba Asari, Xin Wenneng fall apart, therefore all wind and cold headache due to pathogenic wind-dampness, phlegm retention, in the heart stagnant gas, infantile convulsion person, should be used it.Pungently lung can be let out, therefore the upper gas person of cough due to wind and cold should use it." " Mingyi Bielu " Yan Qineng " broken expectorant, dredging water passages, opens breast ... ".Shennong's Herbal records this medicine " main cough with dyspnea ... sharp nine orifices ".Asthma pathogenesis is dirty relevant to lung kidney two, and the pungent temperature disperse function of Herba Asari goes directly lung kidney, and complements each other with other drug.

Cortex Cinnamomi: the property of medicine is pungent, sweet, hot greatly.Return kidney, spleen, the heart, Liver Channel.It is supporing yang that effect mends fire, warming spleen and stomach for dispelling cold, antalgic, a surname's venting QI-blood, conducting fire back to its origin.Its medicinal beginning is loaded in Shennong's Herbal, is classified as top grade, " Your Majesty's gas cough with dyspnea ".Materia Medica of Decoction: " mend the gate of vitality not enough, boosting source of fire for eliminating abundance of yin." " book on Chinese herbal medicine is looked for the truth ": " the large benefit gate of vitality is mutually fiery, Yiyang Zhi Yin.All chronic diseaseses, battalion defend cold type of pain in wind and cold, spontaneous perspiration due to yang insufficiency, abdomen ..., because of cold because of the stagnant and person of obtaining, control with this and invariably imitate." Cortex Cinnamomi falls apart and directly contact skin on medicine cake, can draw all medicines enter through, the kidney warming sun, the heavy cold persistent ailment for the treatment of.

Flos Caryophylli: the property of medicine is pungent, warm, returns spleen, stomach, lung, kidney channel.Effect warming middle-JIAO to send down the adverse QI, dispersing cold for relieving pain, warming the kidney to activate YANG." Japan hanako materia medica ": " control implication, regurgitation, treat kidney qi, sensation of gas rushing, pain over the perineum, tonifying YANG, warm waist knee joint." " book on Chinese herbal medicine is just ": " the fast gas of warming middle-JIAO.Control part of the body cavity above the diaphragm housing the heart and lungs singultus, except cold syndrome of the stomach let out dysentery, seven emotions five are strongly fragrant." Flos Caryophylli and Cortex Cinnamomi draw altogether all medicines enter through, play the effect of warming the kidney to activate YANG cold expelling altogether.

Rhizoma Zingiberis Recens: the property of medicine is pungent, warm, returns lung, spleen, stomach warp.Effect relieving the exterior syndrome by diaphoresis, warming middle-JIAO to arrest vomiting, warming the lung to relieve cough, solving toxin of fish and crab, separates poison of drug." property of medicine opinion " says it: " main expectorant aqueous vapor is full, the therapeutic method to keep the adverse QI flowing downwards; Raw controlling with dry doubling is coughed, disease during treatment, the not lower food of anti-nausea." " Mingyi Bielu " say: " main cold headache nasal obstruction, cough with dyspnea." modern study finds that Rhizoma Zingiberis Recens chemical composition is containing volatile oil.By ginger crush coordinating the actions of various ingredients in a prescription in we, remain the property of medicine of the pungent temperature of Rhizoma Zingiberis Recens, the volatilization had because of it again helps in all medicine transdermals enter.

FEIYU acupoint is the back shu points of lungs, is that the gas infusion of lungs is in the acupuncture points on the human body of lower back.Belong to bladder meridian cave, be positioned at back, under third dorsal vertebra spinous process, side opens 1.5 cun.Fei shu position, near lung, cures mainly the diseases such as cough, asthma, hemoptysis, nasal obstruction." money raw ": " all have breathe heavily and heavy breathing person, for press fei shu, ache invariably, is all Miao thorn fei shu, makes moxibustion and heal." " copper people ": " pass corpse and steam labor, lung withers cough." modern study finds that acupuncture fei shu can strengthen respiratory function, pulmonary ventilation volume, pneusomete oxygen consumption are increased, obviously lowers airway resistance; And fei shu is improved the effect of immunity, to a lot of respiratory system disease, there is dual regulation.

Gaomang point is bladder meridian acupuncture point, is positioned at back, and under fourth dorsal vertebra spinous process, side opens 3 cun.Cure mainly cough, asthma, night sweat etc." prescriptions worth thousand gold ": " region below the heart Yu, without not controlling, main weakness and emaciation is deficient, consumption of essence in dream, upper gas cough with dyspnea, madly puzzledly forgets mistake." " poly-English ": " and go mad, forgetful, expectorant disease." Chang Zuowei asthenia and chronic disease wants cave in modern clinic.

DINGCHUAN acupoint belongs to extra nerve points, i.e. points not mentioned in the ancient medical classics, and under being positioned at back spinous process of the seventh cervical vertebrae, side opens 0.5 cun, cures mainly asthma, cough, stiff neck, pain in the shoulder and back etc., is the experience cave that treatment cough is panted.Modern study finds that acupuncture DINGCHUAN acupoint can reduce bronchial mucosa and ooze out, and removes bronchospasm, improves respiratory function.

The invention has the advantages that:

1, compared with prior art, simple, the good effect of pharmaceutical preparation of the present invention, easy to use.

2, medicine of the present invention can reduce the EOS level of asthmatic children in remission period serum, reduces inflammatory cell infiltration in air flue, alleviates chronic inflammatory disease in bronchus, reduces airway hyperreactivity, thus effectively alleviates developing of asthma.

3, Drug therapy Children with Asthma of the present invention can improve infant lung function index, infant air flue internal resistance is reduced, effectively improves pulmonary ventilation function, and prevention of asthma shows effect, and reduces asthma attack degree.

4, Drug therapy Children with Asthma of the present invention, can reduce infant syndrome integral, reduces asthma attack frequency, significantly improves infant quality of life, plays a role to the biased body constitution of adjustment infant.

5, medicine hurtless measure of the present invention, has no side effect, and can delay asthma attack and alleviate attack degree, improves patients ' life quality.

Accompanying drawing explanation

Accompanying drawing 1 is embodiment 1 treatment group and matched group Sex distribution com-parison and analysis.

Accompanying drawing 2 is embodiment 1 treatment group and matched group age distribution com-parison and analysis.

Accompanying drawing 3 compares with the distributional analysis of the matched group course of disease for embodiment 1 treatment group.

Accompanying drawing 4 is disease com-parison and analysis before embodiment 1 treatment group and treatment of control group.

Accompanying drawing 5 compares with disease integral analysis before and after treatment of control group for embodiment 1 treatment group.

Accompanying drawing 6 is PEF value com-parison and analysis before and after embodiment 1 treatment group and treatment of control group.

Accompanying drawing 7 is EOS value com-parison and analysis before and after embodiment 1 treatment group and treatment of control group.

Accompanying drawing 8 compares with matched group total effects for embodiment 1 treatment group.

Detailed description of the invention

Below in conjunction with detailed description of the invention, set forth the present invention further.Should be understood that these embodiments are only not used in for illustration of the present invention to limit the scope of the invention.In addition should be understood that those skilled in the art can make various changes or modifications the present invention, and these equivalent form of values fall within the application's appended claims limited range equally after the content of having read the present invention's instruction.

Embodiment 1 treats the preparation () of the paracmastic Chinese medicine composition of childhood asthma

Semen Sinapis Albae 6 parts, Rhizoma Corydalis 6 parts, the Radix Angelicae Dahuricae 3 parts, Radix Kansui 3 parts, Herba Asari 3 parts, 10 parts, Rhizoma Zingiberis Recens, Flos Caryophylli 10 parts, Cortex Cinnamomi 10 parts.

Embodiment 2 treats the preparation (two) of the paracmastic Chinese medicine composition of childhood asthma

Semen Sinapis Albae 4 parts, Rhizoma Corydalis 8 parts, the Radix Angelicae Dahuricae 2 parts, Radix Kansui 4 parts, Herba Asari 2 parts, 20 parts, Rhizoma Zingiberis Recens, Flos Caryophylli 2 parts, Cortex Cinnamomi 20 parts.

Embodiment 3 treats the preparation (three) of the paracmastic Chinese medicine composition of childhood asthma

Semen Sinapis Albae 8 parts, Rhizoma Corydalis 4 parts, the Radix Angelicae Dahuricae 4 parts, Radix Kansui 2 parts, Herba Asari 4 parts, 2 parts, Rhizoma Zingiberis Recens, Flos Caryophylli 20 parts, Cortex Cinnamomi 2 parts.

Embodiment 4 treats the preparation (four) of the paracmastic Chinese medicine composition of childhood asthma

Semen Sinapis Albae 4 parts, Rhizoma Corydalis 4 parts, the Radix Angelicae Dahuricae 4 parts, Radix Kansui 4 parts, Herba Asari 3 parts, 12 parts, Rhizoma Zingiberis Recens, Flos Caryophylli 15 parts, Cortex Cinnamomi 12 parts.

Embodiment 5 treats the preparation (five) of the paracmastic Chinese medicine composition of childhood asthma

Semen Sinapis Albae 5 parts, Rhizoma Corydalis 7 parts, the Radix Angelicae Dahuricae 3 parts, Radix Kansui 4 parts, Herba Asari 2 parts, 10 parts, Rhizoma Zingiberis Recens, Flos Caryophylli 15 parts, Cortex Cinnamomi 15 parts.

Embodiment 6 treats the preparation (six) of the paracmastic Chinese medicine composition of childhood asthma

Semen Sinapis Albae 6 parts, Rhizoma Corydalis 5 parts, the Radix Angelicae Dahuricae 3 parts, Radix Kansui 2 parts, Herba Asari 4 parts, 17 parts, Rhizoma Zingiberis Recens, Flos Caryophylli 7 parts, Cortex Cinnamomi 15 parts.

Embodiment 7 treats the preparation (seven) of the paracmastic Chinese medicine composition of childhood asthma

Semen Sinapis Albae 7 parts, Rhizoma Corydalis 7 parts, the Radix Angelicae Dahuricae 2 parts, Radix Kansui 4 parts, Herba Asari 3 parts, 5 parts, Rhizoma Zingiberis Recens, Flos Caryophylli 10 parts, Cortex Cinnamomi 6 parts.

Embodiment 8 treats the preparation (eight) of the paracmastic Chinese medicine composition of childhood asthma

Semen Sinapis Albae 6 parts, Rhizoma Corydalis 4 parts, the Radix Angelicae Dahuricae 4 parts, Radix Kansui 3 parts, Herba Asari 4 parts, 10 parts, Rhizoma Zingiberis Recens, Flos Caryophylli 10 parts, Cortex Cinnamomi 8 parts.

Embodiment 9 treats the preparation that the childhood asthma catabasis applies ointment or plaster

A) preparation method: the arbitrary described Chinese medicine composition of Example 1-8, grinds to form medicated powder by Semen Sinapis, Rhizoma Corydalis, the Radix Angelicae Dahuricae, Radix Kansui, Herba Asari;

B) by ginger crush, step a) in medicated powder Sucus Zingberis be modulated into pasty state and do patent medicine cake;

C) Flos Caryophylli, Cortex Cinnamomi are ground to form medicated powder, be spread on medicine cake and skin contact.

Embodiment 10 clinical research

1. clinical data

1.1 case sources

Collect summer 18 days-August 16 July in 2014 to go to a doctor during dog days in the patient of Shanghai University of Chinese Medicine Affiliated Yueyang Integrated Traditional and Western Medicine Hospital's Pediatric Clinic, asthmatic children in remission period totally 64 examples of capable apply ointment or plaster iontophoresis and MK treatment.

1.2 diagnostic criteria

1.2.1 Western medicine diagnose standard

Formulate with reference to the related content in department of pediatrics branch of Chinese Medical Association pneumatology group revision in 2008 " conventional (trying) diagnosis and treatment guide of children with asthma control ".

(1) recurrent exerbation pant, cough, tachypnea, uncomfortable in chest, many with contact allergen, cold air, physics, chemical irritation, respiratory tract infection and motion etc. relevant, be everlasting night and (or) early morning show effect or aggravate.

(2) during outbreak at two lung audible and be dispersed in or diffusivity, the wheezing sound based on expiratory phase, expiratory phase prolongation.

(3) above-mentioned symptom and the sign effective or spontaneous remission through asthma treatment.

(4) panting except caused by other diseases, cough, tachypnea and uncomfortable in chest.

(5) its atypical clinical manifestations person's (as without obviously panting or wheezing sound), at least should possess following 1: [1] brinchial provocation test or the motion activated test positive; [2] alleged occurrence reversible airflow limitation: 1. Bronchodilation Test is positive: suck quick-acting beta 2 receptor agonist [as albuterol (Salutation)] afterwards 15min forced expiratory volume in first second (FEV1) increase >=12% or 2. asthma treatment is effectively: use bronchodilators and oral (or suction) after glucocorticoid treatment 1-2 week, FEV1 increases >=12%; [3] maximal expiratory flow (PEF) aberration rate every day (monitoring 1 ~ 2 week continuously) 20%.

Meet 1-4 article or the 4th, 5 article of person, can asthma be diagnosed as.

1.2.2 the diagnostic criteria of childhood asthma catabasis

Formulate with reference to the related content in department of pediatrics branch of Chinese Medical Association pneumatology group revision in 2008 " children with asthma diagnosis and treatment guide (revision in 2008) ".

Clinical relieving period means and to disappear through treatment or untreated symptom, sign, and pulmonary function returns to level before acute attack, and maintains more than 3 months.

1.2.3 traditional Chinese medical science asthma and disease typing

Traditional Chinese medical science asthma and asthenia of pulmonosplenic qi are demonstrate,proved, the diagnosis of syndrome of yang deficiency of spleen and kidney is formulated with reference to New Century higher institutions of Chinese medicine 2004 editions seven-year system programming textbook " Pediatrics of Chinese Medicine ".

Traditional Chinese medical science asthma diagnosis reference standard:

(1) there is infancy stage eczema history, allergies, family's asthma history more;

(2) medical history of recurrent exerbation is had.Outbreak is how relevant with some risk factor, as weather cataclysm, suffers from cold and is heated, take food or contact some allergin.There is the tendency such as sneeze, nasal obstruction, cough before outbreak more;

(3) often break out, paroxysm of cough during outbreak, dyspnea with rapid and short breath, out of breath, wheezing sound in the throat, even can not put down sleeping, dysphoria, cyanotic lips;

(4) auscultation of lung two lung audible and wheezing sound, during to exhale obviously, prolonged expiration.If bronchial asthma has secondary infection, audible and moist rales.

Asthma asthenia of pulmonosplenic qi card reference standard: many repeated colds, spontaneous perspiration of breathing hard, coughs unable, the few China of pallor, spiritlessness and sparing of words, the thin poor appetite of shape, large loose stool, pale tongue, white and thin fur, thready and soft pulse.

Asthma syndrome of yang deficiency of spleen and kidney reference standard: pale complexion, coldness of the body with chills, foot is soft unable, dynamic then cardiopalmus of breathing hard, abdominal distention poor appetite, diarrhea with loose stool, clear urine in large amounts, pale tongue, white and thin fur, thready and weak pulse.

Because the how pungent temperature of Chinese medicine composition of the present invention disperses medicine, therefore do not consider including in of YIN-deficiency of the lung and kidney pattern of syndrome, only include asthenia of pulmonosplenic qi card and syndrome of yang deficiency of spleen and kidney in

1.3 test inclusive criterias

(1) meet the diagnosis of traditional Chinese medical science asthma, and belong to asthenia of pulmonosplenic qi pattern of syndrome and deficiency of spleen-YANG and kidneyYANG pattern of syndrome;

(2) doctor trained in Western medicine childhood asthma and catabasis diagnostic criteria is met;

(3) 5-14 year infant, and the person that can coordinate with completed treatment;

(4) other underlying disease of nonjoinder, as: the purple paralysis of congenital heart disease, diabetes, nephrotic syndrome, anaphylaxis etc.;

(5) inform and agree to participate in this experimenter, guardian signs Informed Consent Form.

1.4 test exclusion standards

(1) age is below 5 years old or the patient of more than 14 years old;

(2) be in the seizure of disease phase have heating, cough, the symptom such as to pant, or original symptom sharp deterioration person;

(3) the clear and definite heart, liver, kidney illness and nerve, psychosis, malignant tumor, congenital diseases patient is diagnosed;

(4) row application therapy patient is to drug allergy, or there are furuncle, skin ulcer, furuncle and phyma and skin injury person in acupuncture point place of applying ointment or plaster;

(5) hormone preparation person was used in nearly two weeks.

1.5 test termination criteria

(1) infant compliance is poor, non-completed treatment, or initiative exits this experimenter;

(2) asthma or other diseases outbreak during clinical treatment, can not carry out therapist;

(3) during clinical research there is severe allergic reaction or untoward reaction person in patient.

1.6 research method

1.6.1 case grouping

The infant meeting inclusive criteria is divided into treatment group and matched group, and sample size is according to formula: N1=N2=12.365 × P (1-P)/δ ², according to curative effect and statistics General Requirements in the past, get equivalence margin δ=0.15, average effectiveness level P=0.95, calculate often group and need at least 66 examples, this research finally enters the routine case of group 64 altogether, and infant is divided into treatment group, matched group according to table of random number.

1.6.2 the selection of medicine

Applying ointment or plaster prepared by the Chinese medicine composition of embodiment 1; Menglusitena.

1.6.3 required medicine and device fabrication producer and lot number

Montelukast sodium chewable tablet (Singulair): Hangzhou Mo Shadong pharmaceutical Co. Ltd, the accurate word of traditional Chinese medicines: 4mg:J20130048; 5mg:J20130054;

Semen Sinapis Albae, Rhizoma Corydalis, the Radix Angelicae Dahuricae, Radix Kansui, Herba Asari, Rhizoma Zingiberis Recens, Flos Caryophylli, Cortex Cinnamomi: Shanghai Hua Ying pharmaceutcal corporation, Ltd, HY2013111301; All Chinese medicine grinds preparation by Yueyang hospital pharmacy, fresh ginger juice furnishing pasty state, and the same day was prepared patent medicine cake in treatment.

NPD5AS type ion introducing apparatus: big gun garden, Nanjing electronic technology institute, Soviet Union's food medicine prison tool is produced and is permitted No. 2001-0034;

Mini peak flow meter: PAPI Mini-Wright AFS PEAK FLOW METER;

Routine analysis of blood instrument measures: Sysmex XS-800I.

1.6.4 acupuncture point is selected

Bilateral Dingchuan, feishu, region below the heart is chosen for convenience of operation according to science of acupuncture and moxibustion acupunctare-point locating principle.

1.6.5 treatment group is specifically applied ointment or plaster the time

Treatment group is to last day (on August 16th, 2014) from dog days' first day (on July 18th, 2014), and the next day of from Monday to Saturday, one pastes, and selects the period of the day from 11 a.m. to 1 p.m that in one day, yang-energy is contained most, namely at 11 at noon to afternoon 1 point; Do full dog days totally 9 times, the course for the treatment of of applying ointment or plaster terminates.

1.6.6 application therapy method

The prostrate exposure skin of infant, is directly placed in medicine cake on acupuncture point (6), above puts wet paper towel, electrodes plate, is communicated with ion introducing apparatus." importing " pattern of employing, mixes up " intensity " (tolerating situation according to patient to regulate) and " time " (20 minutes).After machine sends the prompt tone for the treatment of end, take off battery lead plate and medicine cake, wiping infant skin is to clean.

1.6.7 Menglusitena Therapeutic Method

Treatment group and matched group are all taken MK and are amounted to 3 months from dog days' first day; Wherein >=6 years old infant 5mg, Qn, oral; 5 years old infant 4mg, Qn, oral.

1.7 points for attention

Application therapy terminate in latter 2 hours keep apply ointment or plaster place xerosis cutis clean.As skin occurs that local flushing or pigmentation, slightly pruritus are normal phenomenon after applying ointment or plaster, can continual cure.There is skin pain, blister if apply ointment or plaster or after applying ointment or plaster, fester, violent pruritus, stop immediately applying ointment or plaster, note protection wound surface, the infection that avoiding scratches causes, and seek medical advice in time.The food such as period fasting of applying ointment or plaster is raw and cold, pungent, fried, fasting shrimp Eriocheir sinensis seafood etc. easily send out food, the product of the rich easy raw phlegm-damp of fasting.Notice in treatment that wind sheltering is cold, summer-heat.The asthma attack in the course for the treatment of if apply ointment or plaster, stops applying ointment or plaster, uses asthma controller medications in time, if desired to hospital admission.

1.8 observation index

With reference to the new Chinese medicine guideline of clinical investigations 2002 editions that National Drug Administration formulates, the guideline of clinical investigations of new Chinese medicine treatment bronchial wheezing:

(1) before treatment and treat the syndrome integral of latter 6 months:

Main syndromes integration:

Asthma attack number of times (half a year): count 0 point 0 time; Count 2 points 1 time; Count 4 points 2 times; Count 6 points 3 times;

To pant during outbreak degree: without tachypnea meter 0 point; After aggravating activities, tachypnea is panted meter 2 points; After coughing or slightly movable after tachypnea to pant meter 4 points; During rest, tachypnea is panted and can not be put down sleeping meter 6 points;

Times of common cold at ordinary times: count 0 point >=60 days 1 time; Count 2 points 40-60 days 1 time; Count 4 points 30-40 days 1 time; Count 6 points >=30 days 1 time;

Nasal obstruction, rhinocnesmus, sneeze at ordinary times: normal meter 0 point; Every day counts 2 points 1-3 time; Every day more than 4 times counts 4 points; Every day makes meter 6 points frequently;

Secondary syndrome integral:

To breathe hard hyperhidrosis: gas flat movable after normal perspiration meter 0 point; Clothing meter 1 point is made greatly soaked with sweat after aggravating activities; Slightly make greatly clothing meter 2 points after activity soaked with sweat; Clothing meter 3 points is made greatly soaked with sweat during rest;

Spiritlessness and sparing of words: meter 0 point of bracing up; There is feeling of fatigue meter 1 point; There is fatigue and limbs fatigue meter 2 points; Limbs fatigue is drowsy, and lazyness says meter 3 points;

The thin poor appetite of shape: stomach is received and normally counted 0 point; Appetite does not subtract but feels dull meter 1 point; Appetite difference appetite reduces 1/3 2 points; Without appetite; Appetite reduces >=1/2 3 point;

Lustreless complexion: complexion is glossy meter 0 point; Complexion slightly owes gloss meter 1 point; Complexion owes gloss meter 2 points; Dim complexion pool meter 3 points;

Poor appetite loose stool: stomach is received and can be counted 0 point without loose stool; Appetite does not subtract, but feels dull loose stool meter 1 point; Appetite difference loose stool meter 2 points; Without appetite loose stool meter 3 points;

Coldness of the body with chills: the warm meter of limbs 0 point; Chronognosis health cold meter 1 point; The not warm meter of cold four skins of health 2 points; Fear the cool happiness of cold skin and wrap up in clothing meter 3 points;

Pale complexion: meter 0 point of having rosy cheeks; The simple and unadorned meter of pale white complexion 1 point; Mian Se Koushi counts 2 points in vain; Pale complexion meter 3 points

Dynamic then pant: breath steadily counts 0 point; After aggravating activities, tachypnea is panted meter 1 point; After normal activity, tachypnea is panted meter 2 points; Pause movable after tachypnea to pant meter 3 points;

(2) pulmonary function End--tidal PCO_2 (PEF): treatment before and treatment 6 months after compare PEF value.

(3) eosinophil count (EOS): treatment before and treatment 6 months after compare EOS value.

1.9 curative effect determinate standard

With reference to the new Chinese medicine guideline of clinical investigations 2002 editions that National Drug Administration formulates, the guideline of clinical investigations of new Chinese medicine treatment asthma:

(1) clinic control (recovery from illness): PEF recruitment > 35%; Clinical symptoms, sign disappears or substantially disappears, and symptom integral declines >=95%;

(2) effective: PEF recruitment is between 25%-35%; Clinical symptoms, sign significantly take a turn for the better, and symptom integral declines >=70%;

(3) effective: PEF recruitment is between 15%-24%; Clinical symptoms, sign make moderate progress, and symptom integral declines >=30%;

(4) invalid: PEF, without improvement, even reduces; Clinical symptoms, sign, without improvement, are even aggravated, and symptom integral reduces <30%.

1.10 statistical analysis technique

Data acquisition Excel typing, arrangement, adopting the analysis of SPSS17.0 software statistics, is that difference has statistical significance with P<0.05.Measurement data, if data Normal Distribution, adopts mean ± standard deviation to represent; Enumeration data adopts frequency and percentage to form expression.Compare between measurement data group and adopt t inspection.Enumeration data adopts X 2 test.

2. result of study

2.1 general clinical datas

Through screening, 64 examples observe infant all from Yueyang hospital-based outpatient pediatic clinic case, all meet inclusive criteria.Wherein treatment group 33 example, because traditional Chinese medicinal cake allergy exits treatment 1 example, does not adhere to taking Menglusitena treatment 1 example, finally includes research totally 31 examples in, expulsion rate 6.06%.Matched group 31 example, to come off 1 example because following up a case by regular visits to disappearance, finally studies 30 routine altogether, expulsion rate 3.2%.

2.2 harmonious analyses

2.2.1 Sex distribution

This investigates 61 infants altogether, boy student 33 people, schoolgirl 28 people, two groups of sex composition no difference of science of statistics (see table 1 and Fig. 1).

Table 1 Sex distribution com-parison and analysis

Note: through χ ²inspection, P > 0.05, equals 0.05 inspection level according to α, two group difference not statistically significants.

2.2.2 age distribution

Two groups of age recklings 5 years old, the maximum 13 years old, two groups of age distribution no difference of science of statistics (see table 2 and Fig. 2).

Table 2 age distribution com-parison and analysis

Note: through independent samples t-test, P > 0.05, equals 0.05 inspection level according to α, two groups of no significant difference.

2.2.3 course of disease com-parison and analysis

The course of disease the shortest person half a year, most elder 7 years, two groups of courses of disease distribution no difference of science of statistics (see table 3 and Fig. 3).

Table 3 course of disease com-parison and analysis

Note: through χ ²inspection, P > 0.05, two groups of no significant difference.

2.2.4 disease integral contrast before two groups of treatments

Treatment before syndrome integral treatment group be 14.13 ± 3.030, matched group be 12.73 ± 3.912, two groups of Chinese medicine syndrome integral without significant difference, there is comparability (see table 4 and Fig. 4).

Front disease integral contrast treated by table 4

Note: through t inspection, P > 0.05, two groups of no significant difference.

Through inspection display: syndrome integral there was no significant difference (P > 0.05) before the sex of two groups, age, the course of disease and treatment.

2.3 therapeutic outcome analyses

2.3.1 disease integral contrast before and after two groups of treatments

TCM syndrome integral contrast before and after two groups of treatments, in two groups of groups, comparing difference has remarkable statistical significance (P<0.01), before the TCM syndrome integration after treatment is significantly less than treatment; After treatment group and treatment of control group, between group, comparing difference has statistical significance (P<0.05), and the improvement for the treatment of group to disease total mark is better than matched group (see table 5 and Fig. 5).

Syndrome integral com-parison and analysis before and after table 5 liang group treatment

Group	Before treatment	After treatment	t
				Treatment group	14.13±3.030	6.68±2.535	16.767
Matched group	12.73±3.912	7.17±3.860	9.789

Note: through paired t-test, more equal P < 0.01 in treatment group and matched group group; Compare through independent samples t-test, compare between group after two groups of treatments, t=2.622, P=0.01, P < 0.05.Two groups of therapies all can reduce infant syndrome integral, and treatment group is better than matched group.

2.3.2 PEF value com-parison and analysis before and after two groups of treatments

Before and after treatment group and matched group group internal therapy, PEF value compares, equal <0.05, and two groups are all improved PEF value; After treatment group and treatment of control group, between group, PEF value compares, P<0.05, and difference has statistical significance, and treatment group to the improvement of PEF value be better than matched group (see comparatively 6 and Fig. 6).

PEF value com-parison and analysis before and after table 6 liang group treatment

Group	PEF value before treatment	PEF value after treatment	t	P
					Treatment group	316.21±17.811	333.79±12.688	-5.753	0.000
Matched group	315.00±16.330	321.61±18.158	-2.163	0.040

Note: compare through paired t-test, compares the equal P < 0.05 of PEF value in treatment group and matched group group; Compare through independent samples t-test, after treatment group and treatment of control group, between group, PEF value compares, t=0.014, P < 0.05.Two groups of therapies all can improve infant pulmonary function PEF level, and treatment group is better than matched group.

2.3.3 EOS value com-parison and analysis before and after two groups of treatments

Before and after treatment group and matched group group internal therapy, EOS value compares, equal P<0.05, and two groups are all improved EOS value; After treatment group and treatment of control group, between group, EOS value compares, and P<0.05, difference has statistical significance, can think that two groups have statistical significance to EOS value difference is different, and treatment group is better than matched group (see table 7 and Fig. 7) to the improvement of EOS value.

EOS value com-parison and analysis before and after table 7 liang group treatment

Group	EOS value before treatment	EOS value after treatment	t	P
					Treatment group	0.243±0.485	0.194±0.060	6.301	0.000
Matched group	0.243±0.066	0.218±0.061	2.702	0.012

Note: compare through paired t-test, compares EOS value P < 0.05 in group before and after two groups of treatments; Compare through independent samples t-test, after two groups of treatments, between group, EOS value compares, t=2.089, P=0.041, P < 0.05.Two groups of therapies all can improve infant serum EOS level, and treatment group is better than matched group.

2.3.4 two groups of total effects com-parison and analysis

Two groups of total effectses compare P=0.023, P<0.05, and two groups of differences have statistical significance, and treatment group total effective rate 96.8%, matched group total effective rate 76.7%, treatment group total effective rate is due to matched group (see table 8 and Fig. 8).

A table 8 liang group total effects compares

Note: through χ ²inspection, P < 0.05, two groups of differences have statistical significance.Two groups of total effectses compare, and the total efficiently individual quantity for the treatment of group is more than matched group, and invalid number is less than matched group.

3. treating winter disease in summer is applied ointment or plaster ion-introduction therapy treatment asthma Exploration of Mechanism

The improvement result of 3.1 pairs of pulmonary functions

Bronchial asthma causes airway hyper-reaction, makes air flue flow limitation, is chronic airway inflammation disease.China's " prevention and control of bronchial asthma guide " and " global asthma control " are using the goldstandard of lung function as asthma.Lung function tests is the mensuration of the respiratory function be based upon on clinical physiology basis, can be used for clarifying a diagnosis, differentiates mutually with Other diseases, evaluates the order of severity of bronchial asthma, for the formulation for the treatment of asthma scheme and adjustment provide foundation.PEF (pulmonary function End--tidal PCO_2) can the patency of page turning air flue, the coincident with severity degree of condition of judgement asthma and therapeutic effect etc.Namely one of diagnostic criteria of bronchial asthma is aberration rate every day of PEF.

This result of study shows: to apply ointment or plaster ion-introduction therapy and medicine co-therapy children with bronchial asthma disease with treating winter disease in summer, treat latter 6 months compared with before treatment, lung function index PEF value is significantly improved before comparatively treating, contrast before and after treatment difference has statistical significance (P<0.05), and treatment group and simple western medicine matched group comparing difference have statistical significance (P<0.05), prompting treating winter disease in summer apply ointment or plaster ion-introduction therapy treatment children with bronchial asthma disease can improve its PEF level, reduce infant airway resistance and improve pulmonary ventilation with energy, reduce asthma attack number of times and attack degree, improve the quality of life of infant.

3.2 impacts on chronic airway inflammation

The air flue basic pathological changes of Bronchial Asthmas is exactly the infiltration of inflammatory cell, modern medicine finds that the asthma common etiology feature in various typing various period is exactly airway allergy inflammation, the air flue of Bronchial Asthmas is in chronic inflammatory state all the time, EOS (serum oxyphil cell) is a kind of important inflammatory mediator in airway inflammation forming process, reflecting airway inflammation activity, is the most important Histopathological Characteristics that air flue mucosa infiltrates.The main clinical manifestation of asthma is exactly airway obstruction, can be alleviated by rest or various treatment obstructive symptom, Patients with Lung ventilatory function improves, but airway inflammation does not disappear, and lung function can not demonstrate the degree of asthma patient airway hyperreactivity inflammation.Serum EOS reacts air flue course inflammatory activity, the treatment of asthma can be instructed to evaluate therapeutic effect by detecting serum EOS level.

This result of study show: treatment group with after treatment of control group 6 months with treatment before compared with, serum EOS value reduces before comparatively treating, contrast before and after treatment difference has statistical significance (P<0.05), to apply ointment or plaster and treated with combined medication and simple western medicine matched group comparing difference have statistical significance (P<0.05), apply ointment or plaster ion-introduction therapy and the reduction of Western medicine therapeutic alliance to serum of children with asthma EOS level of prompting treating winter disease in summer is better than simple western medicine group, ion-introduction therapy of applying ointment or plaster can alleviate the infiltration of patient airway inflammatory cell, reduce airway allergy inflammation, effectively prevent and treat asthma.

4. conclusion

(1) this research shows that treating winter disease in summer ion-introduction therapy of applying ointment or plaster can reduce the EOS level of asthmatic children in remission period serum, reduce inflammatory cell infiltration in air flue, alleviate chronic inflammatory disease in bronchus, reduce airway hyperreactivity, thus effectively alleviate developing of asthma.

(2) this research shows that treating winter disease in summer ion-introduction therapy treatment Children with Asthma of applying ointment or plaster can improve infant lung function index, and infant air flue internal resistance is reduced, effectively improves pulmonary ventilation function, prevention of asthma shows effect, reduction asthma attack degree.

(3) this research shows that treating winter disease in summer is applied ointment or plaster ion-introduction therapy treatment Children with Asthma, can reduce infant syndrome integral, reduce asthma attack frequency, significantly improve infant quality of life, play a role to the biased body constitution of adjustment infant.

(4) treating winter disease in summer is applied ointment or plaster ion-introduction therapy hurtless measure, has no side effect, can delay asthma attack and alleviate attack degree, improves patients ' life quality.

Embodiment 11 contrast test

1. physical data

In infant 150 example of hospitals of Shanghai Pediatric Clinic during collecting dog days in summer 18 days-August 16 July in 2014, be divided into 5 groups at random, often organize 30 examples; Before the sex of four groups of infants, age, the course of disease, treatment, syndrome integral is through statistical procedures, and no statistical significance, has comparability (P>0.05).The diagnostic criteria of childhood asthma catabasis, observation index, curative effect determinate standard, medicament sources and equipment identical with embodiment 1.

Treatment group one uses applying ointment or plaster prepared by the Chinese medicine composition of embodiment 2, to last day (on August 16th, 2014) from dog days' first day (on July 18th, 2014), the next day of from Monday to Saturday, one pastes, select the period of the day from 11 a.m. to 1 p.m that in one day, yang-energy is contained most, namely at 11 at noon to afternoon 1 point; Do full dog days totally 9 times; Medicine cake is directly placed on acupuncture point (6), above puts wet paper towel, electrodes plate, be communicated with ion introducing apparatus, import 20 minutes.Treatment group two uses applying ointment or plaster prepared by the Chinese medicine composition of embodiment 3, to last day (on August 16th, 2014) from dog days' first day (on July 18th, 2014), the next day of from Monday to Saturday, one pastes, select the period of the day from 11 a.m. to 1 p.m that in one day, yang-energy is contained most, namely at 11 at noon to afternoon 1 point; Do full dog days totally 9 times, medicine cake is directly placed on acupuncture point (6), above puts wet paper towel, electrodes plate, be communicated with ion introducing apparatus, import 20 minutes.Treatment group three infant is used applies ointment or plaster: get 10 parts, Rhizoma Zingiberis Recens and squeeze the juice, and Semen Sinapis Albae 6 parts, Rhizoma Corydalis 6 parts, Radix Kansui 3 parts, Herba Asari 3 is ground to form medicated powder, is modulated into thick paste does patent medicine cake with Sucus Zingberis; Flos Caryophylli 10 parts, Cortex Cinnamomi 10 parts are ground to form medicated powder, be spread on medicine cake and skin contact, to last day (on August 16th, 2014) from dog days' first day (on July 18th, 2014), the next day of from Monday to Saturday, one pastes, select the period of the day from 11 a.m. to 1 p.m that in one day, yang-energy is contained most, namely at 11 at noon to afternoon 1 point; Do full dog days totally 9 times; Medicine cake is directly placed on acupuncture point (6), above puts wet paper towel, electrodes plate, be communicated with ion introducing apparatus, import 20 minutes.Treatment group four infant is used applies ointment or plaster: get 10 parts, Rhizoma Zingiberis Recens and squeeze the juice, Semen Sinapis Albae 6 parts, Rhizoma Corydalis 6 parts, the Radix Angelicae Dahuricae 3 parts, Radix Kansui 3 parts, Herba Asari 3 parts are ground to form medicated powder, be modulated into thick paste with Sucus Zingberis and do patent medicine cake, to last day (on August 16th, 2014) from dog days' first day (on July 18th, 2014), the next day of from Monday to Saturday, one pastes, select the period of the day from 11 a.m. to 1 p.m that in one day, yang-energy is contained most, namely at 11 at noon to afternoon 1 point; Do full dog days totally 9 times; Medicine cake is directly placed on acupuncture point (6), above puts wet paper towel, electrodes plate, be communicated with ion introducing apparatus, import 20 minutes.Treatment group five uses applying ointment or plaster prepared by the Chinese medicine composition of embodiment 1, to last day (on August 16th, 2014) from dog days' first day (on July 18th, 2014), the next day of from Monday to Saturday, one pastes, select the period of the day from 11 a.m. to 1 p.m that in one day, yang-energy is contained most, namely at 11 at noon to afternoon 1 point; Do full dog days totally 9 times; Medicine cake is directly placed on acupuncture point (6), 40 minutes.All treatment groups all amount to 3 months with MK from dog days' first day, wherein >=6 years old infant 5mg, Qn, oral; 5 years old infant 4mg, Qn, oral.

2. curative effect of disease compares

Curative effect of disease comparative result is in table 9, and as can be seen from Table 9, embodiment 1 is the highest for childhood asthma catabasis total effective rate, has significant difference compared with treatment group, and effect is more obvious.

Table 9 six groups of curative effect of disease comparative examples (%)

Group	n	Effective	Effectively	Invalid	Total effective rate (%)
						Embodiment 1	31	3	27	1	96.8
Treatment group one	30	2	23	5	83.3*
						Treatment group two	30	2	23	5	83.3*
Treatment group three	30	1	22	7	76.7*
						Treatment group four	30	2	22	6	80.0*
Treatment group five	30	2	21	7	76.7*

Note: compare * P<0.05 with embodiment 1 total effective rate.

The above is only the preferred embodiment of the present invention; it should be pointed out that for those skilled in the art, under the prerequisite not departing from the inventive method; can also make some improvement and supplement, these improve and supplement and also should be considered as protection scope of the present invention.

Claims (10)

1. the paracmastic Chinese medicine composition for the treatment of childhood asthma, it is characterized in that, it is made up of the crude drug of following weight portion: Semen Sinapis Albae 4-8 part, Rhizoma Corydalis 4-8 part, Radix Angelicae Dahuricae 2-4 part, Radix Kansui 2-4 part, Herba Asari 2-4 part, Rhizoma Zingiberis Recens 2-20 part, Flos Caryophylli 2-20 part, Cortex Cinnamomi 2-20 part.

2. Chinese medicine composition according to claim 1, it is characterized in that, it is made up of the crude drug of following weight portion: Semen Sinapis Albae 5-7 part, Rhizoma Corydalis 5-7 part, the Radix Angelicae Dahuricae 3 parts, Radix Kansui 3 parts, Herba Asari 3 parts, Rhizoma Zingiberis Recens 2-10 part, Flos Caryophylli 2-10 part, Cortex Cinnamomi 2-10 part.

3. Chinese medicine composition according to claim 1, is characterized in that, it is made up of the crude drug of following weight portion: Semen Sinapis Albae 6 parts, Rhizoma Corydalis 6 parts, the Radix Angelicae Dahuricae 3 parts, Radix Kansui 3 parts, Herba Asari 3 parts, Rhizoma Zingiberis Recens 2-10 part, Flos Caryophylli 2-10 part, Cortex Cinnamomi 2-10 part.

4. the application of the arbitrary described Chinese medicine composition of claim 1-3 in the paracmastic medicine of preparation treatment childhood asthma.

5. application according to claim 4, its feature is taken notice of, described medicine, for reducing childhood asthma catabasis patients serum EOS level, reduces inflammatory cell infiltration in air flue, alleviates chronic inflammatory disease in bronchus.

6. application according to claim 4, its feature is taken notice of, described medicine, for reducing childhood asthma catabasis Pulmonary Function index, reduces air flue internal resistance, improves pulmonary ventilation function.

7. application according to claim 6, is characterized in that, described lung function index is PEF value.

8. application according to claim 4, is characterized in that, described medicine medicament be apply ointment or plaster.

9. application according to claim 8, is characterized in that, described is applied to noon in dog days by ion-introduction therapy in patient's bilateral Dingchuan, feishu, region below the heart Acupoint Application in Treating.

10. the preparation method of applying ointment or plaster described in claim 8-9, is characterized in that, comprise the steps:

A) weigh medicine by weight, Semen Sinapis, Rhizoma Corydalis, the Radix Angelicae Dahuricae, Radix Kansui, Herba Asari are ground to form medicated powder;

B) by ginger crush, the medicated powder Sucus Zingberis in step a is modulated into pasty state and does patent medicine cake;

C) Flos Caryophylli, Cortex Cinnamomi are ground to form medicated powder, be spread on medicine cake and skin contact; Described Flos Caryophylli, Cortex Cinnamomi mass ratio are 1:1.