CN104352973A - Chinese patent medicine for postpartum depression - Google Patents
Chinese patent medicine for postpartum depression Download PDFInfo
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- CN104352973A CN104352973A CN201410631039.3A CN201410631039A CN104352973A CN 104352973 A CN104352973 A CN 104352973A CN 201410631039 A CN201410631039 A CN 201410631039A CN 104352973 A CN104352973 A CN 104352973A
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- fructus
- herba
- chinese patent
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Abstract
The invention belongs to the technical field of medicines, and relates to a Chinese patent medicine for postpartum depression. The Chinese patent medicine is prepared from the following raw materials: caltrop, red rhodobryum, foldleaf daylily root, poria cocos, uncaria rhynchophylla, dandelion, medicated leaven, bamboo shavings, trichosanthes kirilowii maxim, rhizoma acori graminei, centella, glossy privet fruit, spina date seed, acanthopanax, asparagus fern, fructus forsythia, sticktight, mangnolia officinalis, herba epimedii, humifuse euphorbia herb, mulberry fruit, radix curcumae, radix stemonae, inula flower root, ligusticum wallichii and cassia twig. The dosage forms such as capsules, tablets and granules are prepared according to a conventional pharmaceutical method. The medicine disclosed by the invention is capable of treating both symptoms and root causes of postpartum depression, and is free of a side effect, low in price, easy to prepare, and wide in application prospect.
Description
Technical field
The invention belongs to medical art, concrete, relate to a kind of Chinese patent medicine for postpartum depression.
Background technology
Depression is also known as depressive disorder, low for main clinical characteristics with remarkable and lasting mental state, is the main Types of mood disorders.Clinical visible mental state is low unbecoming with its situation, and the downhearted of emotion can from depressed to extremely grieved, and depression of feeling oneself inferior is even pessimistic and worldweary, can have suicidal attempt or behavior; Even occur numb; Some cases have obvious anxiety and mobility intense; The psychotic symptoms such as hallucination, vain hope can be there is in severe patient.The cause of disease of depression is also unclear, but certainly, and biological, psychology and all many factors of social environment take part in the pathogenic process of depression.Biological factor relates generally to the aspect such as heredity, neural biochemistry, neuroendocrine, neuranagenesis; It is premorbid personality feature that the psychology in close relations with depression easily suffers from quality, as depressed makings.Manhood meets with irritable life events, is the important trigger condition of the paralepsy causing occurring having clinical meaning.But these factors above are not work separately, emphasize reciprocal action between nature-nurture or stressors at present and thisly interactively occur that time point has important impact in depression generating process.
Postpartum depression is, anorexia depressed with puerperal, tired, sleep disorder, absent minded and deal with baby uncomfortable etc. for a kind of nervous symptoms of feature depressed.Hallucination, autotomy, suicide can be there is time serious.Along with the progress in epoch, increasing people follows late marriage and childbirth, lying-in woman advanced in years is allowed to increase year by year, the sickness rate of postpartum depression in recent years is thereupon caused constantly to increase, the course of disease can delay the several months to the several years, the not only physical and mental health of serious harm puerpera, and cognitive competence, personality, emotion, the behavior disorder that may cause baby.
Current western medical treatment mainly takes antidepressant drug, though there is certain curative effect, such medicine likely produces drug dependence and has certain toxic and side effects.
The traditional Chinese medical science thinks that postpartum depression belongs to the categories such as " puerperal goes mad ", " puerperal is demented " " hysteria in puerperal " by its clinical manifestation.Puerperal blood deficiency, internal organs lose support, internal injury caused by excess of seven emotions, internal organs imbalance of YIN and YANG, the deficient or double expectorant of QI and blood is held concurrently in fire, wet, the stasis of blood etc. and is disturbed the main pathogenesis that gods are primary disease.Patient's ferritic is weak insufficiency of the spleen, or vomiting during pregnancy, and essence and blood biochemistry is passive, and after gestation, the poly-lower fetus nourishing of blood, loses blood when producing in addition, to puerperal blood deficiency more very, blood deficiency the liver failing to be nourished, depression of liver-QI, catharsis neglect one's duty, or puerperal hinder in seven emotions, depressed emotion, liver lose bar reach, develop into postpartum depression.Syndrome of stagnation of liver qi, syndrome of disharmony between heart and kidney, syndrome of deficiency of both heart and spleen.Its pathogenesis, many genus QI and blood and visceral dysfunction, deficiency of vital energy blood fortune is smooth, and channels and collaterals running is obstructed.Treatment then, nourish blood reinforcing the heart unobstructed with QI-blood circulation, tranquilizing the mind, waking up the patient from unconsciousness by clearing away phlegm are principle.
The object of this invention is to provide that a kind for the treatment of both the principal and secondary aspects of a disease, side effect are little, safe ready, cheap Chinese medicine composition.Its objective is to solve treatment postpartum depression, overcome Western medicine toxic and side effects large, easily repeatedly, the inapparent problem of therapeutic effect, reaches the object for the treatment of both the principal and secondary aspects of a disease in drug withdrawal.
The defect that present inventor exists based on the medicine of existing Cure of depression, by the research to Chinese medicine, and in conjunction with dialectical demonstration, in many ways the length of many families is collected, seek therapeutic regimen, from motherland's medical treasure-house, filter out reinforcing the heart of nourishing blood, tranquilizing the mind, the natural Chinese medicine of waking up the patient from unconsciousness by clearing away phlegm, by theory of Chinese medical science prescription, skim the cream off milk, it is made to play to clear away heart-fire place tired, YIN nourishing and the production of body fluid promoting, to calm the nerves the effect nourished heart, adopt natural Chinese medicines raw material, through systematic study, scientific compatibility, the Chinese medicine composition for postpartum depression of the present invention is meticulously mixed with in conjunction with Traditional Chinese Medicine technology, postpartum depression is had to effect of rapid healing.
For achieving the above object, the technical solution used in the present invention is as follows:
For a Chinese patent medicine for postpartum depression, it is characterized in that it is prepared by following raw material and obtains,
Fructus Tribuli, Rhodobryum roseum Limpr., Radix hemerocalis plicatae, Poria, Ramulus Uncariae Cum Uncis, Herba Taraxaci, Massa Medicata Fermentata, Caulis Bambusae In Taenia, Fructus Trichosanthis, Rhizoma Acori Graminei, Herba Centellae, Fructus Ligustri Lucidi, Semen Ziziphi Spinosae, Radix Et Caulis Acanthopanacis Senticosi, Radix Asparagi, Fructus Forsythiae, Herba Bidentis Bipinnatae, Cortex Magnoliae Officinalis, Herba Epimedii, Herba Euphorbiae Humifusae, Fructus Mori, Radix Curcumae, the Radix Stemonae, Radix Inulae, Rhizoma Chuanxiong, Ramulus Cinnamomi.
For a Chinese patent medicine for postpartum depression, it is characterized in that it is prepared by following weight proportioning raw material and obtains,
Fructus Tribuli 30 parts, Rhodobryum roseum Limpr. 30 parts, Radix hemerocalis plicatae 30 parts, 30 parts, Poria,
Ramulus Uncariae Cum Uncis 25 parts, Herba Taraxaci 25 parts, Massa Medicata Fermentata 25 parts, Caulis Bambusae In Taenia 25 parts,
Fructus Trichosanthis 22 parts, Rhizoma Acori Graminei 22 parts, Herba Centellae 22 parts, Fructus Ligustri Lucidi 22 parts,
Semen Ziziphi Spinosae 20 parts, Radix Et Caulis Acanthopanacis Senticosi 20 parts, Radix Asparagi 20 parts, Fructus Forsythiae 20 parts,
Herba Bidentis Bipinnatae 18 parts, Cortex Magnoliae Officinalis 18 parts, Herba Epimedii 15 parts, Herba Euphorbiae Humifusae 15 parts,
Fructus Mori 10 parts, Radix Curcumae 10 parts, the Radix Stemonae 10 parts, Radix Inulae 8 parts,
Rhizoma Chuanxiong 5 parts, Ramulus Cinnamomi 5 parts.
Medicine of the present invention can add one or more pharmaceutically acceptable carriers and be mixed and made into any one clinically or pharmaceutically acceptable dosage form, preferred oral preparation.When being applied in the mode of oral administration the patient needing this treatment, conventional solid preparation can be made into, as tablet, capsule, soft capsule etc.
Preferably, its preparation method is:
(1) get Fructus Tribuli, Rhodobryum roseum Limpr., Radix hemerocalis plicatae, Poria, Ramulus Uncariae Cum Uncis, Herba Taraxaci, Massa Medicata Fermentata, Caulis Bambusae In Taenia, Fructus Trichosanthis, Herba Epimedii, Herba Euphorbiae Humifusae, Fructus Mori, Radix Curcumae, the Radix Stemonae, Radix Inulae mix in described ratio, add the ethanol relative to mixture 3-5 times amount 95%, reflux, extract, 3 times, each 2 hours, extracting solution merges, and is concentrated into the clear paste that density is 1.25g/ml, 80 DEG C of oven dry, be ground into powder, be complex A;
(2) get surplus stock medicine and add 5 times of soak by water twice, 2 hours first times, second time 1 hour, merges twice decoction liquor, and it is the extractum of 1.25g/ml that drying under reduced pressure obtains density, after 80 DEG C of oven dry, is ground into powder, is complex B;
(3) by complex A and complex B mixing and stirring, sterilization obtains capsule product.
Chinese medicine mind tranquilizing and the heart calming of the present invention, reinforcing the heart of nourishing blood, tranquilizing the mind, waking up the patient from unconsciousness by clearing away phlegm nourishing the liver and kidney, have definite curative effect to postpartum depression, side effect is little.Fill blood, nourish heart kidney.
Usage and dosage: oral, a 1g, three times on the one.
Attention: hyperpietic avoids clothes, warm water delivery service.Period in a medicine avoids pungent food and cold and cool food, and avoid emotional stimulation, life is regular.
The Chinese patent medicine excellent results that the present invention is used for postpartum depression is:
1. the present invention meets Chinese medicine " monarch " principle for the Chinese medicine preparation compatibility of postpartum depression, be made up of pure Chinese medicine, each component meets pharmaceutical control law regulation, utilize the comprehensive function of each taste Chinese medicine, not containing chemical components, not containing hormone, have no side effect, treating both the exterior and interior, reaches better enriching yin and nourishing kidney, tranquilizing by nourishing the heart effect;
2. this medicament short treating period, total effective rate is high, not easily recurs more.
3. technique of the present invention is simple, reduces production cost, alleviates the financial burden of patient.
Detailed description of the invention
Embodiment 1
For a Chinese patent medicine for postpartum depression, it is prepared by following weight proportioning raw material and obtains
Fructus Tribuli 30 parts, Rhodobryum roseum Limpr. 30 parts, Radix hemerocalis plicatae 30 parts, 30 parts, Poria,
Ramulus Uncariae Cum Uncis 25 parts, Herba Taraxaci 25 parts, Massa Medicata Fermentata 25 parts, Caulis Bambusae In Taenia 25 parts,
Fructus Trichosanthis 22 parts, Rhizoma Acori Graminei 22 parts, Herba Centellae 22 parts, Fructus Ligustri Lucidi 22 parts,
Semen Ziziphi Spinosae 20 parts, Radix Et Caulis Acanthopanacis Senticosi 20 parts, Radix Asparagi 20 parts, Fructus Forsythiae 20 parts,
Herba Bidentis Bipinnatae 18 parts, Cortex Magnoliae Officinalis 18 parts, Herba Epimedii 15 parts, Herba Euphorbiae Humifusae 15 parts,
Fructus Mori 10 parts, Radix Curcumae 10 parts, the Radix Stemonae 10 parts, Radix Inulae 8 parts,
Rhizoma Chuanxiong 5 parts, Ramulus Cinnamomi 5 parts.
Its preparation method is:
(1) get Fructus Tribuli, Rhodobryum roseum Limpr., Radix hemerocalis plicatae, Poria, Ramulus Uncariae Cum Uncis, Herba Taraxaci, Massa Medicata Fermentata, Caulis Bambusae In Taenia, Fructus Trichosanthis, Herba Epimedii, Herba Euphorbiae Humifusae, Fructus Mori, Radix Curcumae, the Radix Stemonae, Radix Inulae mix in described ratio, add the ethanol relative to mixture 3 times of weight 95%, reflux, extract, 3 times, each 2 hours, extracting solution merges, and is concentrated into the clear paste that density is 1.25g/ml, 80 DEG C of oven dry, be ground into powder, be complex A;
(2) surplus stock medicine and Rhizoma Acori Graminei, Herba Centellae, Fructus Ligustri Lucidi, Semen Ziziphi Spinosae, Radix Et Caulis Acanthopanacis Senticosi, Radix Asparagi, Fructus Forsythiae, Herba Bidentis Bipinnatae, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong, Ramulus Cinnamomi is got, add 5 times of soak by water twice, 2 hours first times, second time 1 hour, merge twice decoction liquor, it is the extractum of 1.25g/ml that decoction liquor drying under reduced pressure is obtained density, after 80 DEG C of oven dry, be ground into powder, be complex B;
(3) by complex A and complex B mixing and stirring, sterilization obtains capsule product.
Usage and dosage: oral, a 1g, three times on the one.
Embodiment 2
Studies on acute toxicity
Acute toxicity testing: application mice 40, male and female half and half, body weight 30 ~ 40g, carries out acute toxicity test.Mice is divided into two groups at random, i.e. matched group and administration group, often organize 20, fasting 12 hours before experiment, Chinese patent medicine prepared by embodiments of the invention 1 is dissolved in gastric infusion in water (gavage unit dosage form is 50g crude drug/kg), matched group gives normal saline, administration in one day 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record mice toxic reaction and death toll.Experimental result shows: compare with matched group, and after administration, mice has no notable difference, and experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increase all normal.Therefore Chinese patent medicine acute toxicity of the present invention is extremely low, clinical drug safety.
Long term toxicity test: Chinese medicine embodiment 1 capsule of the present invention is to mice continuous use 15 weeks and drug withdrawal after 3 weeks, result shows: the index such as hair, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of Chinese medicine of the present invention to mice all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 15 weeks and drug withdrawal are after 3 weeks, and Organs of Mice is all without obviously changing.Illustrate that Chinese medicine of the present invention is little to toxicity after mice long-term prescription, also there is no difference reaction after drug withdrawal, application safety.
Embodiment 3
1, clinical data
Choose patient 107 example with complete data, be divided into two groups immediately, treatment group and matched group, wherein treatment group 53 people, 21 ~ 40 years old age, primipara 39 example, multipara 14 example; Cesarean 31 example, spontaneous labor 22 example; Patients with mild 7 example, moderate patient 37 example, severe patient 9 example; Matched group 54 people, 20 ~ 39 years old age, primipara 38 example, multipara 16 example; Cesarean 30 example, spontaneous labor 24 example; Patients with mild 8 example, moderate patient 36 example, severe patient 10 example.Two groups in age, childbirth options, parturition number, symptom and coincident with severity degree of condition etc. through statistical analysis there was no significant difference (p>0.05).There is comparability.
1, diagnostic criteria: the diagnostic criteria according to postpartum depression in Americanism association " diagnostic & statistical manual of mental sickness ": the symptom (at least one item in first 2 must be possessed) occurring following more than 5 or 5 within two weeks puerperal: be 1. in a very depressed state; 2. to all or most movable interest and joyful of obviously lacking; 3. body weight significantly declines or increases; 4. insomnia or hypersomnia; 5. psychomotor excitement or retardance; 6. tired or weak; 7. all feel meaningless when anything crops up or have from crime sense; 8. thinking ability go down or attention defeated and dispersed; 9. repeatedly there is dead idea.All patients get rid of brain disorder, mental disorder history, mental disorder family history.Depressive illness is divided into 3 degree according to Hamilton depressive scale (HAMD scale) standards of grading: slight: total score at 8 ~ 20 points, moderate: total score at 21 ~ 35 points, severe: total score is more than 35 points.
Therapeutic Method:
Matched group: oral paroxetine, every day 20mg, 1 time on the 1st, 8 weeks courses for the treatment of.
Treatment group: give Chinese medicine embodiment 1 capsule of the present invention each 1g, every day 3 times, 8 weeks courses for the treatment of.
Two groups all give psychological counseling, and adjustment patient emotion, establishes the confidence of Fighting Disease.
Curative effect judging standard: before treating, treated for 2,4,8 weekends, using the deduction rate of HAMD scale score as parameters for observation on effect, total mark before deduction rate=(before treatment the rear total mark of total mark-treatment)/treatment, adopt 4 grade standards that the whole nation is unified: clinical cure: transference cure, HAMD (deduction to 7 point below) deduction rate >=80%;
Effective: symptom major part disappears, 50%≤HAMD deduction rate <80%;
Take a turn for the better: symptom partial disappearance or degree alleviate, 25%≤HAMD deduction rate <50%;
Invalid: symptom is unchanged or increase the weight of, HAMD deduction rate <25%.
Therapeutic outcome: treatment group and comparing, in table 1 complying total effects.
| Group | Example time | Recovery from illness | Effective | Effectively | Invalid | Total effective rate (%) |
| Treatment group | 53 | 20 | 19 | 10 | 4 | 92.4 |
| Matched group | 54 | 9 | 20 | 13 | 12 | 77.7 |
As seen from the above table: cure rate and the total effective rate for the treatment of group are all obviously better than matched group, have significant difference.
Embodiment 3
Exemplary embodiments
Jiang, 37 years old, advanced age multipara, Cesarean esction.Occur depression phenomenon in puerperal, it is postpartum depression that doctor is diagnosed as, and treat for Jiang opens medicine, take medicine after 3 wheat harvesting periods, the state of an illness does not take a turn for the better; After giving the capsule preparations of embodiment 1 preparation, through about 2 months take, and the psychological auxiliary treatment of necessity, conditions of patients is clearly better, and checks, substantially fully recover through doctor.Follow up a case by regular visits to half a year without recurrence.
Liu, 29 years old, primipara.Cesarean before 3 months, postpartum hemorrhage is many, depressed because occurring after house hold affairs quarrel, bradyphrenia, insomnia and dreamful sleep, and tired weak, the symptoms such as attention is defeated and dispersed, get rid of brain diseases and mental disorder history, be diagnosed as postpartum depression.Give the capsule preparations of Chinese medicine embodiment 1 of the present invention preparation, give psychological consultation treatment simultaneously.After treating 8 weeks, clinical cure.Follow up a case by regular visits to and do not recur half a year.
Above-mentioned each Chinese medicinal components that the present invention adopts makes compatibility mutually, its collaborative effect of curing the disease can be played, there is between each composition of raw material of Chinese medicine used drug effect be interweaved and mutually promote and coordinate usefulness, through clinical verification, have good therapeutic effect to postpartum depression, in the applicant's medical practice for many years, the case Numerous of curing, all obtains good effect, and with low cost, alleviate the burden of patient, have broad application prospects.
Claims (4)
1. for a Chinese patent medicine for postpartum depression, it is characterized in that, described Chinese patent medicine is prepared by following crude drug and obtains,
Fructus Tribuli, Rhodobryum roseum Limpr., Radix hemerocalis plicatae, Poria, Ramulus Uncariae Cum Uncis, Herba Taraxaci, Massa Medicata Fermentata, Caulis Bambusae In Taenia, Fructus Trichosanthis, Rhizoma Acori Graminei, Herba Centellae, Fructus Ligustri Lucidi, Semen Ziziphi Spinosae, Radix Et Caulis Acanthopanacis Senticosi, Radix Asparagi, Fructus Forsythiae, Herba Bidentis Bipinnatae, Cortex Magnoliae Officinalis, Herba Epimedii, Herba Euphorbiae Humifusae, Fructus Mori, Radix Curcumae, the Radix Stemonae, Radix Inulae, Rhizoma Chuanxiong, Ramulus Cinnamomi.
2. Chinese patent medicine according to claim 1, is characterized in that, described Chinese patent medicine is prepared by the crude drug of following weight portion and obtains,
Fructus Tribuli 30 parts, Rhodobryum roseum Limpr. 30 parts, Radix hemerocalis plicatae 30 parts, 30 parts, Poria,
Ramulus Uncariae Cum Uncis 25 parts, Herba Taraxaci 25 parts, Massa Medicata Fermentata 25 parts, Caulis Bambusae In Taenia 25 parts,
Fructus Trichosanthis 22 parts, Rhizoma Acori Graminei 22 parts, Herba Centellae 22 parts, Fructus Ligustri Lucidi 22 parts,
Semen Ziziphi Spinosae 20 parts, Radix Et Caulis Acanthopanacis Senticosi 20 parts, Radix Asparagi 20 parts, Fructus Forsythiae 20 parts,
Herba Bidentis Bipinnatae 18 parts, Cortex Magnoliae Officinalis 18 parts, Herba Epimedii 15 parts, Herba Euphorbiae Humifusae 15 parts,
Fructus Mori 10 parts, Radix Curcumae 10 parts, the Radix Stemonae 10 parts, Radix Inulae 8 parts,
Rhizoma Chuanxiong 5 parts, Ramulus Cinnamomi 5 parts.
3. the preparation method of Chinese patent medicine described in claim 1-2, is characterized in that, described preparation method comprises the steps:
(1) Fructus Tribuli, Rhodobryum roseum Limpr., Radix hemerocalis plicatae, Poria, Ramulus Uncariae Cum Uncis, Herba Taraxaci, Massa Medicata Fermentata, Caulis Bambusae In Taenia, Fructus Trichosanthis, Herba Epimedii, Herba Euphorbiae Humifusae, Fructus Mori, Radix Curcumae, the Radix Stemonae, Radix Inulae is got, mixing, add the ethanol relative to mixture 3-5 times weight 95%, reflux, extract, 3 times, each 2 hours, extracting solution merged, be concentrated into the clear paste that density is 1.25g/ml, 80 DEG C of oven dry, are ground into powder, are complex A;
(2) get surplus stock medicine, add 5 times of soak by water twice, 2 hours first times, second time 1 hour, merges twice decoction liquor, and it is the extractum of 1.25g/ml that drying under reduced pressure obtains density, after 80 DEG C of oven dry, is ground into powder, is complex B;
(3) by complex A and complex B mixing and stirring, sterilization obtains capsule product.
4. Chinese patent medicine described in claim 1-3 is used for the purposes in postpartum depression Drug therapy.
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| CN105617279A (en) * | 2016-03-03 | 2016-06-01 | 林炜 | Preparation method of traditional Chinese medicine for treating depression |
| AU2015203074B1 (en) * | 2015-06-10 | 2016-10-20 | Thisherb Health Pty Ltd | Pharmaceutical composition for treatment of depression and preparation method thereof |
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2014
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| 王秀珍 等: "中西医结合治疗产后抑郁症60例", 《中国中医药现代远程教育》 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2015203074B1 (en) * | 2015-06-10 | 2016-10-20 | Thisherb Health Pty Ltd | Pharmaceutical composition for treatment of depression and preparation method thereof |
| EP3307294A4 (en) * | 2015-06-10 | 2018-05-30 | Thisherb Health Pty Ltd. | Pharmaceutical composition for treatment of depression and preparation method thereof |
| JP2018516995A (en) * | 2015-06-10 | 2018-06-28 | ディスハーブ ヘルス ピーティーワイ リミテッドＴｈｉｓｈｅｒｂ Ｈｅａｌｔｈ Ｐｔｙ Ｌｔｄ | Pharmaceutical composition for the treatment of depression and method for its preparation |
| CN105617279A (en) * | 2016-03-03 | 2016-06-01 | 林炜 | Preparation method of traditional Chinese medicine for treating depression |
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