CN102716260B - Medicine for fast improving sperm quality and sexual function - Google Patents
Medicine for fast improving sperm quality and sexual function Download PDFInfo
- Publication number
- CN102716260B CN102716260B CN201210215679.7A CN201210215679A CN102716260B CN 102716260 B CN102716260 B CN 102716260B CN 201210215679 A CN201210215679 A CN 201210215679A CN 102716260 B CN102716260 B CN 102716260B
- Authority
- CN
- China
- Prior art keywords
- medicine
- sexual function
- sperm quality
- quick
- sexual
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000003814 drug Substances 0.000 title claims abstract description 78
- 230000036299 sexual function Effects 0.000 title claims abstract description 32
- 229940079593 drug Drugs 0.000 title description 11
- 239000002994 raw material Substances 0.000 claims abstract description 5
- 238000000034 method Methods 0.000 claims description 13
- 239000003390 Chinese drug Substances 0.000 claims description 12
- 230000008569 process Effects 0.000 claims description 12
- 239000002775 capsule Substances 0.000 claims description 9
- 239000006187 pill Substances 0.000 claims description 9
- 239000000843 powder Substances 0.000 claims description 5
- 239000003795 chemical substances by application Substances 0.000 claims description 3
- 239000008187 granular material Substances 0.000 claims description 2
- 235000012907 honey Nutrition 0.000 claims description 2
- 239000007788 liquid Substances 0.000 claims description 2
- 239000000463 material Substances 0.000 claims description 2
- 235000015091 medicinal tea Nutrition 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 22
- 238000011282 treatment Methods 0.000 abstract description 18
- 201000001881 impotence Diseases 0.000 abstract description 7
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 abstract description 6
- 235000003140 Panax quinquefolius Nutrition 0.000 abstract description 6
- 235000008434 ginseng Nutrition 0.000 abstract description 6
- 210000000582 semen Anatomy 0.000 abstract description 6
- 230000001737 promoting effect Effects 0.000 abstract description 3
- 230000004083 survival effect Effects 0.000 abstract description 3
- 231100000331 toxic Toxicity 0.000 abstract description 3
- 230000002588 toxic effect Effects 0.000 abstract description 3
- 238000000605 extraction Methods 0.000 abstract description 2
- 206010036596 premature ejaculation Diseases 0.000 abstract description 2
- 241001289529 Fallopia multiflora Species 0.000 abstract 1
- 244000303040 Glycyrrhiza glabra Species 0.000 abstract 1
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 abstract 1
- 235000017784 Mespilus germanica Nutrition 0.000 abstract 1
- 244000182216 Mimusops elengi Species 0.000 abstract 1
- 235000000560 Mimusops elengi Nutrition 0.000 abstract 1
- 244000131316 Panax pseudoginseng Species 0.000 abstract 1
- 241000304195 Salvia miltiorrhiza Species 0.000 abstract 1
- 235000011135 Salvia miltiorrhiza Nutrition 0.000 abstract 1
- 240000006079 Schisandra chinensis Species 0.000 abstract 1
- 235000008422 Schisandra chinensis Nutrition 0.000 abstract 1
- 235000007837 Vangueria infausta Nutrition 0.000 abstract 1
- 230000002950 deficient Effects 0.000 abstract 1
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 abstract 1
- 235000011477 liquorice Nutrition 0.000 abstract 1
- 239000006186 oral dosage form Substances 0.000 abstract 1
- 230000035946 sexual desire Effects 0.000 abstract 1
- 208000024891 symptom Diseases 0.000 abstract 1
- 230000001568 sexual effect Effects 0.000 description 19
- 230000001225 therapeutic effect Effects 0.000 description 10
- 201000010099 disease Diseases 0.000 description 9
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 9
- 230000003203 everyday effect Effects 0.000 description 7
- 241000208340 Araliaceae Species 0.000 description 5
- 210000004369 blood Anatomy 0.000 description 5
- 239000008280 blood Substances 0.000 description 5
- 230000036541 health Effects 0.000 description 5
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 4
- 206010021929 Infertility male Diseases 0.000 description 4
- 208000007466 Male Infertility Diseases 0.000 description 4
- 230000004899 motility Effects 0.000 description 4
- 210000003899 penis Anatomy 0.000 description 4
- 210000001215 vagina Anatomy 0.000 description 4
- 208000010228 Erectile Dysfunction Diseases 0.000 description 3
- 206010003883 azoospermia Diseases 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 238000003748 differential diagnosis Methods 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 238000007689 inspection Methods 0.000 description 3
- 238000011835 investigation Methods 0.000 description 3
- 210000003734 kidney Anatomy 0.000 description 3
- 230000000144 pharmacologic effect Effects 0.000 description 3
- 229940126680 traditional chinese medicines Drugs 0.000 description 3
- 241001251068 Formica fusca Species 0.000 description 2
- 229930003427 Vitamin E Natural products 0.000 description 2
- 208000027418 Wounds and injury Diseases 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 230000017531 blood circulation Effects 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 230000006870 function Effects 0.000 description 2
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 2
- 241000411851 herbal medicine Species 0.000 description 2
- 208000014674 injury Diseases 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 238000009781 safety test method Methods 0.000 description 2
- 230000021595 spermatogenesis Effects 0.000 description 2
- 210000000952 spleen Anatomy 0.000 description 2
- 238000007619 statistical method Methods 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 210000001550 testis Anatomy 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- 231100000041 toxicology testing Toxicity 0.000 description 2
- 229940046009 vitamin E Drugs 0.000 description 2
- 235000019165 vitamin E Nutrition 0.000 description 2
- 239000011709 vitamin E Substances 0.000 description 2
- 239000008783 wuzi yanzong Substances 0.000 description 2
- 102100026041 Acrosin Human genes 0.000 description 1
- 108090000107 Acrosin Proteins 0.000 description 1
- 101710153593 Albumin A Proteins 0.000 description 1
- 102000004625 Aspartate Aminotransferases Human genes 0.000 description 1
- 108010003415 Aspartate Aminotransferases Proteins 0.000 description 1
- 208000031404 Chromosome Aberrations Diseases 0.000 description 1
- 206010014328 Ejaculation failure Diseases 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 208000004930 Fatty Liver Diseases 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 108010023302 HDL Cholesterol Proteins 0.000 description 1
- 206010019708 Hepatic steatosis Diseases 0.000 description 1
- 101100510715 Homo sapiens LDHC gene Proteins 0.000 description 1
- 206010062767 Hypophysitis Diseases 0.000 description 1
- 206010021118 Hypotonia Diseases 0.000 description 1
- 229930010555 Inosine Natural products 0.000 description 1
- UGQMRVRMYYASKQ-KQYNXXCUSA-N Inosine Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C2=NC=NC(O)=C2N=C1 UGQMRVRMYYASKQ-KQYNXXCUSA-N 0.000 description 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 1
- 102100031357 L-lactate dehydrogenase C chain Human genes 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 244000046052 Phaseolus vulgaris Species 0.000 description 1
- 235000010627 Phaseolus vulgaris Nutrition 0.000 description 1
- 101710098398 Probable alanine aminotransferase, mitochondrial Proteins 0.000 description 1
- 206010050208 Teratospermia Diseases 0.000 description 1
- 208000002312 Teratozoospermia Diseases 0.000 description 1
- 102000003929 Transaminases Human genes 0.000 description 1
- 108090000340 Transaminases Proteins 0.000 description 1
- PNNCWTXUWKENPE-UHFFFAOYSA-N [N].NC(N)=O Chemical compound [N].NC(N)=O PNNCWTXUWKENPE-UHFFFAOYSA-N 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000000680 avirulence Effects 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 230000006735 deficit Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000000378 dietary effect Effects 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 238000002651 drug therapy Methods 0.000 description 1
- 230000009977 dual effect Effects 0.000 description 1
- 235000018927 edible plant Nutrition 0.000 description 1
- 208000030172 endocrine system disease Diseases 0.000 description 1
- 230000037149 energy metabolism Effects 0.000 description 1
- 230000009986 erectile function Effects 0.000 description 1
- 210000003743 erythrocyte Anatomy 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 208000010706 fatty liver disease Diseases 0.000 description 1
- 208000017561 flaccidity Diseases 0.000 description 1
- 229930003935 flavonoid Natural products 0.000 description 1
- 150000002215 flavonoids Chemical class 0.000 description 1
- 235000017173 flavonoids Nutrition 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 235000008216 herbs Nutrition 0.000 description 1
- 210000003016 hypothalamus Anatomy 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 208000021267 infertility disease Diseases 0.000 description 1
- 229960003786 inosine Drugs 0.000 description 1
- 230000003907 kidney function Effects 0.000 description 1
- 210000000265 leukocyte Anatomy 0.000 description 1
- -1 lipid peroxide Chemical class 0.000 description 1
- 230000003908 liver function Effects 0.000 description 1
- 230000033001 locomotion Effects 0.000 description 1
- 206010025482 malaise Diseases 0.000 description 1
- 235000012054 meals Nutrition 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 230000007102 metabolic function Effects 0.000 description 1
- 238000000874 microwave-assisted extraction Methods 0.000 description 1
- 239000011664 nicotinic acid Substances 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 208000008634 oligospermia Diseases 0.000 description 1
- 230000036616 oligospermia Effects 0.000 description 1
- 231100000528 oligospermia Toxicity 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 230000035935 pregnancy Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 201000007094 prostatitis Diseases 0.000 description 1
- 238000001671 psychotherapy Methods 0.000 description 1
- 230000005180 public health Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 208000012201 sexual and gender identity disease Diseases 0.000 description 1
- 208000015891 sexual disease Diseases 0.000 description 1
- 239000008925 shengjing Substances 0.000 description 1
- 230000000391 smoking effect Effects 0.000 description 1
- 210000004872 soft tissue Anatomy 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 230000019100 sperm motility Effects 0.000 description 1
- 230000000920 spermatogeneic effect Effects 0.000 description 1
- 231100000240 steatosis hepatitis Toxicity 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000000194 supercritical-fluid extraction Methods 0.000 description 1
- 238000002636 symptomatic treatment Methods 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
- 238000002137 ultrasound extraction Methods 0.000 description 1
- 201000004822 varicocele Diseases 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses medicine for fast improving the sperm quality and the sexual function. The medicine is prepared by using medlar, herba epimedii, polygonum multiflorum, salvia miltiorrhiza, cortex acanthopanacis, semen cuscutae, ginseng, liquorice and schisandra chinensis as raw materials through extraction according to a certain weight ratio. The medicine can be prepared into any one ordinary oral dosage form. Clinical observation and laboratory study prove that the medicine has the fast and obvious treatment efficacy on symptoms with smaller sperm quantity, lower vitality, survival rate insufficiency and many defective sperms, has a good effect of promoting the sexual desire and improving the sexual function and has a good heath-care effect on male impotence and premature ejaculation, and through clinical observation, the effect taking speed is high, and the toxic or side effect is avoided.
Description
Technical field
The present invention relates to the medicine of the high sperm quality of a kind of Quick and sexual function, particularly relate to a kind of taking botanical herbs and be all the Chinese medicine raising sperm quality that make as raw material, that there is treating both the principal and secondary aspects of a disease function of Chinese medicine health care product or medicine-food two-purpose and the medicine of male's sexual.
Background technology
Being declined and sexual disorder by the sperm quality that factor causes in many ways, is common clinical disease.In recent years, due to ecological deterioration, many-sided many reasons such as chemical contamination, physical factor, dietary factor, the sterile ascendant trend that presented that mankind spermatozoon Quality Down causes, meanwhile, also there is reduction in various degree in male's sexual.The height of its sickness rate, seriously has influence on the harmony of happy family life and love life.
Aspect treatment male sterility, although clinical existing WUZIYANZONG WAN, SHENGJING JIAONANG, compound recipe Formica fusca capsule etc. have the medicine of Spermatogenic action, but these medicines are unsatisfactory to the dual raising of spermatogenesis effect and sexual function, aspect safety, do not have with medicine-food two-purpose medicine and health care Chinese medicine prescription person, not only can not improve sperm quality simultaneously yet but also can improve such medicine of male's sexual.
Aspect the treatment and health care of male sterility and male's sexual, Chinese medicine has certain advantage, but because kind is single, effect is non-very good again, has limited the different various selections that need of patient.Providing safer, more resultful special-purpose medicaments for clinical, is very necessary.
Clinical data is verified, and the average every 8-10 of China to there being 1 pair of appearance sterile in Mr. and Mrs, and wherein male factor accounts for 40%-50%, and male is especially common with oligospermia, azoospermia.Some western medicine male sterilities, types of drugs is on the low side, and lacks pointed Western medicine.Modern pharmacology research is found, Chinese medicine can change sperm protein matter molecular structure, promote the membrane structure change of pathologic sperm to make it reach spermioteleosis state, improve acrosin LDHX activity simultaneously, promote DNA synthetic, improve sperm energy metabolism, suppress infected by microbes, reduce active oxygen and lipid peroxide level.
In China, due to the reason of the aspects such as society, economy and tradition, Chinese medicine remains one of Main Means for the treatment of male sterility, further curative effect and the Pharmacodynamical mechanism of Study of Traditional Chinese Medicine prescription so as to develop effectively and reasonably, the novel drugs of safe and economic raising mankind spermatozoon quality.At present, the medicine of the high sperm quality of weary Quick and male's sexual still clinically.Make a general survey of Chinese medicine and western medicine market, it is blank that such medicine still belongs to.
Summary of the invention
The object of the present invention is to provide the medicine of the high sperm quality of a kind of Quick and sexual function, medicine of the present invention is less to sperm quantity, low sperm activity, sperm motility rate are not enough has a fast significant therapeutic efficiency with teratospermia is too much etc., to promoting male's libido, raising sexual function to there is good action, impotence, premature ejaculation are had to good health-care effect simultaneously.
The present invention realizes with following technical scheme.The medicine of the high sperm quality of a kind of Quick and sexual function, it is characterized in that it is to be prepared from by the material medicine of following weight parts: Fructus Lycii 6-60 part, Herba Epimedii 6-60 part, Radix Polygoni Multiflori 6-60 part, Radix Salviae Miltiorrhizae 6-60 part, Cortex Acanthopancis 3-45 part, Semen Cuscutae 6-60 part, Radix Ginseng 3-45 part, Radix Glycyrrhizae 6-36 part, Fructus Schisandrae Chinensis 6-60 part.
The high sperm quality of described a kind of Quick with the preferred component ratio of the each raw material of medicine of sexual function is: Fructus Lycii 10-45 part, Herba Epimedii 10-45 part, Radix Polygoni Multiflori 10-50 part, Radix Salviae Miltiorrhizae 10-50 part, Cortex Acanthopancis 10-35 part, Semen Cuscutae 10-50 part, Radix Ginseng 10-30 part, Radix Glycyrrhizae 10-30 part, Fructus Schisandrae Chinensis 10-36 part.
The present invention is taking the traditional organic conception of the traditional Chinese medical science as prescription criterion, and invigorating kidney qi is with replenishing essence, and blood stasis dispelling is invigorated blood circulation with except stagnant, and short essence generates educates with benefit.Fructus Lycii, Herba Epimedii, Radix Polygoni Multiflori, Semen Cuscutae invigorating kidney qi in side, to promoting spermatogenesis, improve sperm quality and have mastery reaction; Radix Salviae Miltiorrhizae, Cortex Acanthopancis blood stasis dispelling are invigorated blood circulation, and strong rigidity of soft tissues bone, mends five kinds of strain and seven kinds of impairment; Radix Ginseng, Radix Glycyrrhizae invigorating the spleen and replenishing QI are except stagnant, and emphatically auxiliary the foundation of acquired constitution, so that kidney spleen synchronously nourishes; Fructus Schisandrae Chinensis promotes the metabolic function of testis tissue cell, and arrenotoky ability is had to the effect of significantly improving.
Make a general survey of full side, medication is made a distinction between the important and the lesser one, fill a prescription ingenious reasonable, effect brings out the best in each other, and is dialectically combined with differential diagnosis of diseases, and Chinese and Western medicine is closed ginseng, medicine used all proves through the relevant pharmacological evaluation of modern medicine effective property and the reliability that it promotes sperm quality, and every herbal medicine is all within health care Chinese medicine or medicinal and edible Chinese medicine category, safety well ensured, pharmacology also all prompting there is no obvious toxic and side effects.
Medicine of the present invention embodies the dialectical feature combining with differential diagnosis of diseases, and meets the basic principle of middle medical drugs completely.
Moreover, the pharmacological action of said medicine, all has relevant pharmacological research and animal experiment conclusion to confirm.
The medicine of the high sperm quality of above-mentioned Quick and sexual function, can adopt the conventional method of Chinese medicine preparation to make any dosage form for oral administration.
The medicine of the high sperm quality of above-mentioned a kind of Quick and sexual function adopts pharmaceutics of Chinese drugs common process to make capsule.
The medicine of the high sperm quality of above-mentioned a kind of Quick and sexual function adopts pharmaceutics of Chinese drugs common process to make tablet.
The medicine of the high sperm quality of above-mentioned a kind of Quick and sexual function adopts pharmaceutics of Chinese drugs common process to make powder or granule.
The medicine of the high sperm quality of above-mentioned a kind of Quick and sexual function adopts pharmaceutics of Chinese drugs common process to make watered pill, honey pill agent, water-honeyed pill, concentrated pill or drop pill.
The medicine of the high sperm quality of above-mentioned a kind of Quick and sexual function adopts pharmaceutics of Chinese drugs common process to make oral liquid.
The medicine of the high sperm quality of above-mentioned a kind of Quick and sexual function adopts pharmaceutics of Chinese drugs common process to make medicinal tea.
The pharmaceutical formulation of the high sperm quality of above-mentioned a kind of Quick and sexual function also can adopt the method effective component extractings such as semi-bionic extraction, supercritical fluid extraction, microwave extraction, enzyme engineering technology, ultrasonic extraction, Flavonoids by Macroporous Adsorption Resin, and these extracting modes are all within protection scope of the present invention.
The medicine of the high sperm quality of a kind of Quick and sexual function shows to have following advantage through result in clinical application:
1, the choice of drug natural edible-plant medicine of the high sperm quality of a kind of Quick and sexual function is raw material, each component meets Medicine Act regulation and tcm prescription principle, the outstanding basic characteristic that Chinese medical discrimination combines with doctor trained in Western medicine differential diagnosis of diseases, etiological treatment combines with symptomatic treatment;
2, a medicine finished product oral agents for the high sperm quality of Quick and sexual function, mouthfeel is better, taking convenience, all nontoxic before and after each herbal medicine prescription, normal dose is taken and is not found any toxic and side effects;
3, the transaminase that the medicine of the high sperm quality of Quick and sexual function causes liver function injury raises and has a good therapeutic effect with fatty liver, also has good functions of prevention and health care, applied widely;
4, all selected kinds that specifies to do Chinese medicine health-care or medicine-food two-purpose in Ministry of Public Health of the medicine of the high sperm quality of Quick and sexual function, safety is higher, when treatment, can take the long period;
5, a medicine treating both the principal and secondary aspects of a disease for the high sperm quality of Quick and sexual function, takes effect rapidly, and cure rate is high.
Detailed description of the invention
Medicine of the present invention is through clinical observation on the therapeutic effect and safety testing, shows for oral administration safe and reliablely, and therapeutic effect is remarkable, has certain popularization and practical value.
Embodiment 1
Fructus Lycii 10-45 part Herba Epimedii 10-45 part Radix Polygoni Multiflori 10-50 part Radix Salviae Miltiorrhizae 10-50 part
Cortex Acanthopancis 10-35 part Semen Cuscutae 10-50 part Radix Ginseng 10-30 part Radix Glycyrrhizae 10-30 part
Fructus Schisandrae Chinensis 10-36 part.
Produce and make every containing the capsule that extracts 0.45 gram, medicated powder by Jiangsu Yi Hai Pharmaceutical Co.
Clinical experiment example 1: low sperm activity (azoospermia)
Physical data
Hospital is Continuous Observation low sperm activity patient 396 examples within a period of time, are divided at random two groups.Two groups of patients are all from outpatient service, the course of disease 6 months to 3 years 5 months.Observation group's 198 examples, age 23-37 year; Matched group 198 examples, age 24-37 year.Two groups have comparability.
Case selection
Two groups of low sperm activity persons, through inspection sperm a level b level sum be less than 50% or the sperm of a level motion be less than 25%, get rid of that sperm antibody (AsAb) is positive, more than moderate varicocele, prostatitis, seminal fluid not liquefaction, testicualr development is abnormal, deferent duct blocks, Tesicle injury, functional anejaculation, clearly have diseases such as hypothalamus, hypophysis, testis endocrinopathy and chromosomal abnormality.Wherein motility of sperm is normal value minimum >=70% 147 examples, < 136 examples, < 113 examples.Patient's random packet, two groups of there was no significant differences.
Therapeutic Method
Medicament capsule of the present invention is taken by observation group, and every day 3 times, each 4 (every containing extracting 0.45 gram, medicated powder, by Jiangsu, Yi Hai Pharmaceutical Co produces, lower same), takes continuously, within 3 months, is 1 course for the treatment of.
Matched group oral administered compound Formica fusca capsule 40mg, every day 3 times; Vitamin E capsule (the accurate word H36020414 of traditional Chinese medicines, Jiangxi Tian Hai pharmaceutcal corporation, Ltd, lot number: 20051201,1 100mg), each 1, every day 2 times.Taking continuously, 3 months was 1 course for the treatment of.
Equal wine for giving off smoking, fasting Herba Apii graveolentis during two groups of treatments, prohibit a large amount of edible bean product, prohibits pungent stimulation food.
Therapeutic outcome
Criterion of therapeutical effect: evaluate according to relevant criterion of therapeutical effect in WHO " infertile couples standard checks and diagnosis handbook " reference " new Chinese medicine guideline of clinical investigations ".Effective: after motility of sperm treatment, a level adds b level > 50% or a level > 25%, survival rate 1h > 60%; Effective: motility of sperm a adds b level or a level promotes > 30%, and survival rate 1h promotes > 30%; Invalid: after treatment, motility of sperm promotes less than 30% or unchanged.
Statistical method: application SPSS13.0 statistics software, calculating chart with
represent, between group relatively with user documents (shipped with equipment) t inspection, enumeration data chi-square criterion, P < 0.05 has statistical significance for difference.
Efficacy analysis: treat after 1 course for the treatment of, result observation group obvious effective rate and total effective rate are all higher than matched group, and two groups have significant difference, P < 0.05.For details see attached table 1.
The contrast of 1 liang of group low sperm activity therapeutic effect of subordinate list
Clinical experiment example 2: sexual impotence
Physical data
Case selection: observe impotence case 122 examples.Age is 22-55 year, and the course of disease is 9 months-33 months.Once Drug therapy 26 examples, psychotherapy's 16 examples.
Case, all from outpatient service, is divided into two groups at random, there was no significant difference between group.
Observation caliber: the diagnostic criteria with reference to " new Chinese medicine guideline of clinical investigations " about sexual impotence.And according to patient's different clinical manifestation on individuality, there are one of following 3 kinds of situations, and can include observation in: 1. under sex drive and property require, penis anorthosis, normally sexual intercourse; 2. when sexual requirement, penis can erect, but erection intensity or hardness are inadequate, and penis is difficult to insert intravaginal and completes normal sexual intercourse; 3. when sexual requirement, penis can erect and erection degree or hardness still can, hold time of short durationly but erect, after not yet inserting vagina or inserting vagina, be the soft normally sexual intercourse of flaccidity.
Therapeutic Method
Treatment group: take medicament capsule of the present invention, every day 3 times, each 4 (every containing extracting 0.45 gram, medicated powder), takes continuously, 3 months is 1 course for the treatment of.
Matched group: take WUZIYANZONG WAN (Luoyang Junshan Pharmaceutical Co., Ltd., the accurate word Z21020225 of traditional Chinese medicines) each 6g, every day 2 times, vitamin E (Beijing Double-Crane Pharmaceutical Co., Ltd, the accurate word H11021397 of traditional Chinese medicines) each 100mg, every day 2 times.Taking continuously, 3 months was 1 course for the treatment of.
Therapeutic outcome
Curative effect determinate standard: criterion of therapeutical effect, with reference to curative effect grade, the relevant industries standard of " new Chinese medicine guideline of clinical investigations ", is drafted the efficacy assessment standard of sexual impotence.Clinical cure: erection can naturally enter vagina and complete normal sexual intercourse, sexual life is satisfied, success rate of sexual intercourse >=75%; Effective: erection enters vaginal intercourse with hand steered holding, and sexual life is satisfied in the main, success rate of sexual intercourse is 50%-74%; Effective: penile erectile function is treated front improvement but can not be entered smoothly vagina, occasionally can hand steeredly hold and enter vaginal intercourse, sexual life is dissatisfied, and success rate of sexual intercourse is 26%-49%; Invalid: with more unchanged or increase the weight of before treatment, non-access, sexual life is not satisfied at all, and success rate of sexual intercourse is less than 25%.
Statistical method: application SPSS13.0 statistics software, calculating chart with
represent, between group relatively with user documents (shipped with equipment) t inspection, enumeration data chi-square criterion, P < 0.05 has statistical significance for difference.
Efficacy analysis: treat after 1 course for the treatment of, result observation group clinical cure rate and total effective rate are all higher than matched group, and two groups have significant difference, P < 0.05.For details see attached table 2.
2 liang of group impotence treatment effect comparisons of subordinate list
Clinical example 3: safety testing
Test method
Test crowd: in order to observe this medicine, normal human is had to avirulence, we select 40 examples (average 32 ± 5.9 years old of age) healthy premenopausal volunteers (except gestation or women breast-feeding their children), adopt self cross-reference form.
Instructions of taking: every day 3 times, each 4-6 grain, 0.45 gram every, one after each meal, continuous 3 weeks.Medicament capsule is provided by Jiangsu Yi Hai Pharmaceutical Co.
Observation index
Safety observation index mainly comprises total protein TP, albumin A LB, darling renal function (glutamic oxaloacetic transaminase, GOT AST, glutamate pyruvate transaminase ALT, blood urea nitrogen BUN, inosine CRE), blood glucose GLU, blood fat (T-CHOL TC, triglyceride TG, HDL-C HDL-C), Hb H GB, erythrocyte RBC, leukocyte WBC, urinates ten.
Result of the test
Tested volunteer fore-and-aft observing achievement data is learned by statistics and is processed there was no significant difference (P ﹥ 0.05).
Observed result for details see attached table 3.
Subordinate list 3 safety indexes detection case
Claims (8)
1. a medicine for the high sperm quality of Quick and sexual function, is characterized in that it is to be prepared from by the material medicine of following weight parts:
2. the medicine of the high sperm quality of Quick and sexual function as claimed in claim 1, is characterized in that: the weight portion of the each raw material of described Chinese medicine composition is:
3. the medicine of the high sperm quality of a kind of Quick and sexual function as claimed in claim 1, is characterized in that adopting pharmaceutics of Chinese drugs common process to make capsule.
4. the medicine of the high sperm quality of a kind of Quick and sexual function as claimed in claim 1, is characterized in that adopting pharmaceutics of Chinese drugs common process to make tablet.
5. the medicine of the high sperm quality of a kind of Quick and sexual function as claimed in claim 1, is characterized in that adopting pharmaceutics of Chinese drugs common process to make powder or granule.
6. the medicine of the high sperm quality of a kind of Quick and sexual function as claimed in claim 1, is characterized in that adopting pharmaceutics of Chinese drugs common process to make watered pill, honey pill agent, concentrated pill or drop pill.
7. the medicine of the high sperm quality of a kind of Quick and sexual function as claimed in claim 1, is characterized in that adopting pharmaceutics of Chinese drugs common process to make oral liquid.
8. the medicine of the high sperm quality of a kind of Quick and sexual function as claimed in claim 1, is characterized in that adopting pharmaceutics of Chinese drugs common process to make medicinal tea.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210215679.7A CN102716260B (en) | 2012-06-27 | 2012-06-27 | Medicine for fast improving sperm quality and sexual function |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210215679.7A CN102716260B (en) | 2012-06-27 | 2012-06-27 | Medicine for fast improving sperm quality and sexual function |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102716260A CN102716260A (en) | 2012-10-10 |
| CN102716260B true CN102716260B (en) | 2014-12-10 |
Family
ID=46942214
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201210215679.7A Active CN102716260B (en) | 2012-06-27 | 2012-06-27 | Medicine for fast improving sperm quality and sexual function |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102716260B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104873594A (en) * | 2014-02-28 | 2015-09-02 | 曾正 | Traditional Chinese medicine liquor for treating male kidney deficiency |
| CN106421601A (en) * | 2016-10-25 | 2017-02-22 | 孙光周 | Traditional Chinese medicine potion for treating teratospermia and preparation method thereof |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1119117A (en) * | 1995-07-22 | 1996-03-27 | 万乙妙 | Dachengzhuangyang wine for strengthening yang |
| CN1370457A (en) * | 2001-02-23 | 2002-09-25 | 梁晨 | Health food |
| CN102475800A (en) * | 2010-11-27 | 2012-05-30 | 叶奉奇 | Tablets used for controlling aspermia infertility |
-
2012
- 2012-06-27 CN CN201210215679.7A patent/CN102716260B/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CN102716260A (en) | 2012-10-10 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102526474B (en) | Chinese medicine composition for treating neurasthenia | |
| CN100493597C (en) | Medicine composition for treating neurosis | |
| CN101670060A (en) | Traditional Chinese medicine composition for treating such diseases as hepatic stagnation, chest stuffiness and distension and preparation method | |
| CN104027529A (en) | Traditional Chinese medicine composition for regulating blood lipids, blood pressure and blood glucose and preparation method thereof | |
| CN104274789A (en) | Traditional Chinese medicine composition for treating depression | |
| CN102698077A (en) | Traditional Chinese medicine composition for treating sub-health | |
| CN102716260B (en) | Medicine for fast improving sperm quality and sexual function | |
| CN101628104B (en) | Traditional Chinese medicine composition used for treating melancholia | |
| CN103142754A (en) | Traditional Chinese medicine for treating kidney deficiency | |
| CN104383421A (en) | Pharmaceutical preparation for treating insomnia and dreaminess | |
| CN104383420A (en) | Preparation method of pharmaceutical preparation for treating insomnia and dreaminess | |
| CN100509043C (en) | Chinese medicine composition for eliminating drug addication | |
| CN104352973A (en) | Chinese patent medicine for postpartum depression | |
| CN112741890A (en) | Traditional Chinese medicine composition for treating vertigo and preparation method thereof | |
| CN101658626A (en) | Chinese herba preparation for treating depression | |
| CN101406625B (en) | Chinese medicinal composition for treating cancer as well as preparation method and use thereof | |
| CN109758559A (en) | A kind of Chinese medicine composition and its preparation method and application for treating chronic fatigue syndrome | |
| CN102727730B (en) | Traditional Chinese medicinal compound preparation for treating male infertility and its preparation method | |
| CN104324134A (en) | Traditional Chinese medicine composition for improving microcirculation and preparation method of traditional Chinese medicine composition | |
| CN104645246B (en) | A kind of pharmaceutical preparation depressed for Menopause | |
| CN102416147B (en) | Medicinal composition for treating mania of patients abstained from drugs | |
| CN111671795B (en) | Traditional Chinese medicine composition for treating diabetic peripheral neuropathy, traditional Chinese medicine preparation and application | |
| CN100571722C (en) | Treatment is suffered from a deficiency of the kidney and the pharmaceutical composition of climacteric syndrome and preparation method thereof | |
| CN104383441A (en) | Method for preparing Chinese patent medicine for treating postpartum depression | |
| CN105941773A (en) | Health care tea and application thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20190724 Address after: 511458 X1301-E2535, No. 106 Fengze East Road, Nansha District, Guangzhou City, Guangdong Province Patentee after: Yuanshengtai (Guangzhou) Biotechnology Co.,Ltd. Address before: Room 101, Unit 3, Building 4, Hongrun Garden, Gulou District, Xuzhou City, Jiangsu Province, 221008 Patentee before: Wang Zhongmin |
|
| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20240222 Address after: Room 401, Building 1, No. 10 Huancui South Road, Liwan District, Guangzhou City, Guangdong Province, 510000 Patentee after: Fengmao Holdings (Guangdong) Co.,Ltd. Country or region after: China Patentee after: Wang Zhongmin Address before: 511458, No.106 Fengze East Road, Nansha District, Guangzhou City, Guangdong Province (self designated Building 1) X1301-E2535 Patentee before: Yuanshengtai (Guangzhou) Biotechnology Co.,Ltd. Country or region before: China |