CN102716260A - Medicine for fast improving sperm quality and sexual function - Google Patents
Medicine for fast improving sperm quality and sexual function Download PDFInfo
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- CN102716260A CN102716260A CN2012102156797A CN201210215679A CN102716260A CN 102716260 A CN102716260 A CN 102716260A CN 2012102156797 A CN2012102156797 A CN 2012102156797A CN 201210215679 A CN201210215679 A CN 201210215679A CN 102716260 A CN102716260 A CN 102716260A
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Abstract
The invention discloses medicine for fast improving the sperm quality and the sexual function. The medicine is prepared by using medlar, herba epimedii, polygonum multiflorum, salvia miltiorrhiza, cortex acanthopanacis, semen cuscutae, ginseng, liquorice and schisandra chinensis as raw materials through extraction according to a certain weight ratio. The medicine can be prepared into any one ordinary oral dosage form. Clinical observation and laboratory study prove that the medicine has the fast and obvious treatment efficacy on symptoms with smaller sperm quantity, lower vitality, survival rate insufficiency and many defective sperms, has a good effect of promoting the sexual desire and improving the sexual function and has a good heath-care effect on male impotence and premature ejaculation, and through clinical observation, the effect taking speed is high, and the toxic or side effect is avoided.
Description
Technical field
The present invention relates to the medicine of a kind of quick raising sperm quality and sexual function, particularly relate to a kind of with botanical herbs and all be that the Chinese medicine of Chinese medicine health care product or medicine-food two-purpose is that raw material is processed, as to have the treating both the principal and secondary aspects of a disease function raising sperm quality and the medicine of male's sexual.
Background technology
Sperm quality by factor initiation in many ways descends and sexual disorder, is common clinical disease.In recent years, since ecological deterioration, many-sided many reasons such as chemical contamination, physical factor, dietary factor, the sterile ascendant trend that appeared that the mankind spermatozoon downgrade causes, simultaneously, reduction in various degree also appears in male's sexual.The height of its sickness rate seriously has influence on the harmony of happy family life and love life.
Aspect the treatment male sterility; Although clinical existing WUZIYANZONG WAN, SHENGJING JIAONANG, compound recipe XUANJU capsule etc. have the medicine of Spermatogenic action; But these medicines are unsatisfactory to the dual raising of spermatogenesis effect and sexual function; Aspect safety, do not have with medicine-food two-purpose medicine and health care Chinese prescription person, not only can not improve sperm quality simultaneously but also can improve such medicine of male's sexual yet.
Aspect the treatment and health care of male sterility and male's sexual, Chinese medicine has certain advantage, but because kind is single, effect is non-again very good, has limited various selection of patient's different needs.For clinical safer, more resultful special-purpose medicaments being provided, is very necessary.
Clinical data is verified, and the average every 8-10 of China is to promptly there being 1 pair of appearance sterile among the Mr. and Mrs, and wherein male factor accounts for 40%-50%, and the male sees so that oligospermia, azoospermia more especially.Some western medicine male sterilities, types of drugs is on the low side, and lacks pointed Western medicine.Modern pharmacology is discovered; Chinese medicine can change sperm protein matter molecular structure, promotes the membrane structure change of pathologic sperm to make it reach the spermioteleosis state, and it is active to improve acrosin LDHX simultaneously; Promote DNA synthetic; Improve the sperm energy metabolism, suppress infected by microbes, reduce active oxygen and lipid peroxide level.
In China; Reason owing to aspects such as society, economy and tradition; Chinese medicine remains one of main means of treatment male sterility, further studies the curative effect and the drug effect mechanism of Chinese medicinal formulae, so as to develop effectively and reasonably, the novel drugs of safe and economic raising mankind spermatozoon quality.At present, the still weary clinically medicine that improves sperm quality and male's sexual fast.Make a general survey of Chinese medicine and western medicine market, such medicine still belongs to blank.
Summary of the invention
The object of the present invention is to provide the medicine of a kind of quick raising sperm quality and sexual function; Medicine of the present invention is less to sperm quantity, low sperm activity, sperm motility rate are not enough with teratospermia is too much etc. has a fast significant therapeutic efficiency; To promoting male's libido, sexual function improvement to have good action, impotence, premature ejaculation had the good health care effect simultaneously.
The present invention realizes with following technical scheme.The medicine of a kind of quick raising sperm quality and sexual function is characterized in that it is to be prepared from the following raw medicaments in portion by weight thing: Fructus Lycii 6-60 part, Herba Epimedii 6-60 part; Radix Polygoni Multiflori 6-60 part, Radix Salviae Miltiorrhizae 6-60 part, Cortex Acanthopancis 3-45 part; Semen Cuscutae 6-60 part; Radix Ginseng 3-45 part, Radix Glycyrrhizae 6-36 part, Fructus Schisandrae Chinensis 6-60 part.
Said a kind of quick raising sperm quality with the preferred component ratio of each raw material of medicine of sexual function is: Fructus Lycii 10-45 part, Herba Epimedii 10-45 part, Radix Polygoni Multiflori 10-50 part; Radix Salviae Miltiorrhizae 10-50 part; Cortex Acanthopancis 10-35 part, Semen Cuscutae 10-50 part, Radix Ginseng 10-30 part; Radix Glycyrrhizae 10-30 part, Fructus Schisandrae Chinensis 10-36 part.
The present invention is the prescription criterion with the traditional organic conception of the traditional Chinese medical science, and invigorating kidney qi is with replenishing essence, and blood stasis dispelling is invigorated blood circulation and stagnated to remove, and short smart the generation educated with benefit.Fructus Lycii, Herba Epimedii, Radix Polygoni Multiflori, Semen Cuscutae invigorating kidney qi in the side to promoting spermatogenesis, improve sperm quality and have mastery reaction; Radix Salviae Miltiorrhizae, Cortex Acanthopancis blood stasis dispelling are invigorated blood circulation, and strong rigidity of soft tissues bone is mended five kinds of strain and seven kinds of impairment; Radix Ginseng, Radix Glycyrrhizae invigorating the spleen and replenishing QI remove and stagnate, and emphatically auxiliary the foundation of acquired constitution is so that the kidney spleen nourishes synchronously; Fructus Schisandrae Chinensis promotes the metabolic function of testis tissue cell, and the arrenotoky ability is had the effect of significantly improving.
Make a general survey of full side, medication is made a distinction between the important and the lesser one, and it is ingenious reasonable to fill a prescription; Effect brings out the best in each other, and dialectically combines with differential diagnosis of diseases, and Chinese and Western medicine is closed ginseng; All it promotes the produce effects property and the reliability of sperm quality to institute's medicament through the relevant pharmacological evaluation proof of modern medicine; And every herbal medicine is all within health care Chinese medicine or medicinal and edible Chinese medicine category, and safety well guaranteed, pharmacology also all prompting do not have obvious toxic and side effects.
Medicine of the present invention embodies the dialectical characteristics that combine with differential diagnosis of diseases, and meets the basic principle of middle medical drugs fully.
Moreover, the pharmacological action of said medicine all has relevant pharmacological research and animal experiment conclusion to confirm.
The medicine of above-mentioned quick raising sperm quality and sexual function can adopt the conventional method of Chinese medicine preparation to process any dosage form for oral administration.
The medicine of above-mentioned a kind of quick raising sperm quality and sexual function adopts the pharmaceutics of Chinese drugs common process to process capsule.
The medicine of above-mentioned a kind of quick raising sperm quality and sexual function adopts the pharmaceutics of Chinese drugs common process to process tablet.
The medicine of above-mentioned a kind of quick raising sperm quality and sexual function adopts the pharmaceutics of Chinese drugs common process to process powder or granule.
The medicine of above-mentioned a kind of quick raising sperm quality and sexual function adopts the pharmaceutics of Chinese drugs common process to process watered pill, honey pill agent, water-honeyed pill, concentrated pill or drop pill.
The medicine of above-mentioned a kind of quick raising sperm quality and sexual function adopts the pharmaceutics of Chinese drugs common process to process oral liquid.
The medicine of above-mentioned a kind of quick raising sperm quality and sexual function adopts the pharmaceutics of Chinese drugs common process to process medicinal tea.
The pharmaceutical formulation of above-mentioned a kind of quick raising sperm quality and sexual function also can adopt method effective component extractings such as semi-bionic extraction, supercritical fluid extraction, microwave extraction, enzyme engineering technology, ultrasonic extraction, macroporous adsorbent resin method, and these extracting modes are all within protection scope of the present invention.
The medicine of a kind of quick raising sperm quality and sexual function shows to have following advantage through clinical use result:
1, the choice of drug natural edible-plant medicine of a kind of quick raising sperm quality and sexual function is a raw material; Each component meets Medicine Act regulation and tcm prescription principle, the outstanding basic characteristic that Chinese medical discrimination combines with the doctor trained in Western medicine differential diagnosis of diseases, etiological treatment combines with symptomatic treatment;
2, the medicine finished product oral agents of a kind of quick raising sperm quality and sexual function, mouthfeel is better, taking convenience, all nontoxic before and after each herbal medicine prescription, normal dose is taken and is not found any toxic and side effects;
3, the medicine of a kind of quick raising sperm quality and sexual function has excellent curative to transaminase's rising that liver function injury causes with fatty liver, and the good preventing health-care effect is also arranged, and the scope of application is extensive;
4, the medicine of a kind of quick raising sperm quality and sexual function is all selected can do the kind of Chinese medicine health-care or medicine-food two-purpose in Ministry of Public Health regulation, and safety is higher, but the long period takes during treatment;
5, the medicine treating both the principal and secondary aspects of a disease of a kind of quick raising sperm quality and sexual function takes effect rapidly, and cure rate is high.
The specific embodiment
Medicine of the present invention is through clinical observation on the therapeutic effect and safety testing, shows for oral administration safe and reliablely, and therapeutic effect is remarkable, has certain popularization and practical value.
Embodiment 1
Fructus Lycii 10-45 part Herba Epimedii 10-45 part Radix Polygoni Multiflori 10-50 part Radix Salviae Miltiorrhizae 10-50 part
Cortex Acanthopancis 10-35 part Semen Cuscutae 10-50 part Radix Ginseng 10-30 part Radix Glycyrrhizae 10-30 part
Fructus Schisandrae Chinensis 10-36 part.
Nourish the production of extra large Pharmaceutical Co by Jiangsu and process every capsule that contains extraction medicated powder 0.45 gram.
Clinical experiment example 1: low sperm activity (azoospermia)
Physical data
Hospital observes low sperm activity patient 396 examples continuously in a period of time, be divided into two groups at random.Two groups of patients are all from outpatient service, the course of disease 6 months to 3 years 5 months.Observation group's 198 examples, age 23-37 year; Matched group 198 examples, age 24-37 year.Two groups have comparability.
Case is selected
Two groups of low sperm activity persons; Through check sperm a level b level sum be less than 50% or the sperm of a level motion be less than 25%, get rid of sperm antibody (AsAb) is positive, moderate is above varicocele, prostatitis, seminal fluid not liquefaction, testicualr development is unusual, deferent duct blocks, testis wound, functional anejaculation, clearly diseases such as hypothalamus, hypophysis, testis endocrinopathy and chromosomal abnormality are arranged.Wherein motility of sperm is normal value minimum >=70% 147 examples,＜70% 136 examples,＜30% 113 examples.Patient's random packet, two groups of there was no significant differences.
Therapeutic Method
Medicament capsule of the present invention is taken by observation group, every day 3 times, each 4 (every contains extraction medicated powder 0.45 gram, nourishes extra large Pharmaceutical Co by Jiangsu and produces, down together), and take continuously, 3 months was 1 course of treatment.
Matched group oral administered compound XUANJU capsule (the accurate word H13021485 of traditional Chinese medicines, Shineway Pharmaceutical Co., Ltd produces, lot number: 20051201, the 20mg/ grain) 40mg, every day 3 times; Vitamin E capsule (the accurate word H36020414 of traditional Chinese medicines, Jiangxi Tian Hai pharmaceutcal corporation, Ltd, lot number: 20051201,1 100mg), and each 1, every day 2 times.Take continuously, 3 months was 1 course of treatment.
Equal wine for giving off smoking, fasting Herba Apii graveolentis during two groups of treatments are prohibited a large amount of edible bean product, prohibit pungent stimulation food.
Therapeutic outcome
Criterion of therapeutical effect: " inspection of infertile couples standard is evaluated with the diagnosis handbook and with reference to relevant criterion of therapeutical effect in " new Chinese medicine clinical research guideline " according to WHO.Produce effects: motility of sperm treatment back a level adds b level＞50% or a level＞25%, survival rate 1h＞60%; Effectively: motility of sperm a adds the b level or a level promotes＞30%, and survival rate 1h promotes＞30%; Invalid: treatment back motility of sperm promotes less than 30% or no change.
Statistical method: use SPSS13.0 statistics software; Calculating chart is represented with
; Relatively check between group with user documents (shipped with equipment) t; Enumeration data is used chi-square criterion, and there is statistical significance P＜0.05 for difference.
Efficacy analysis: after treating 1 course of treatment, observation group's obvious effective rate and total effective rate all are higher than matched group as a result, and two groups have significant difference, P＜0.05.For details see attached table 1.
The contrast of 1 liang of group of subordinate list low sperm activity therapeutic effect
Clinical experiment example 2: sexual impotence
Physical data
Case is selected: observe impotence case 122 examples.Age is 22-55 year, and the course of disease is 9 months-33 months.Drug therapy 26 examples once, psychotherapy's 16 examples.
Case is divided into two groups at random all from outpatient service, there was no significant difference between group.
Observation caliber: with reference to " new Chinese medicine clinical research guideline " diagnostic criteria about sexual impotence.And according to patient's different clinical performance on individuality, one of following 3 kinds of situation appear, and can include observation in: 1. under sex drive and property requirement, penis anorthosis, normally sexual intercourse; 2. during sexual the requirement, penis can erect, but erection intensity or hardness are not enough, and penis is difficult to insert intravaginal and accomplishes normal sexual intercourse; 3. during sexual the requirement, penis can erect and erection degree or hardness still can, hold time of short durationly but erect, be the soft normally sexual intercourse of flaccidity after not inserting vagina as yet or inserting vagina.
Therapeutic Method
The treatment group: take medicament capsule of the present invention, every day 3 times, each 4 (every contains extraction medicated powder 0.45 gram), and take continuously, 3 months was 1 course of treatment.
Matched group: take the each 6g of WUZIYANZONG WAN (Luoyang Junshan Pharmaceutical Co., Ltd., the accurate word Z21020225 of traditional Chinese medicines), every day 2 times, each 100 mg of vitamin E (Beijing Double-Crane Pharmaceutical Co., Ltd, the accurate word H11021397 of traditional Chinese medicines), every day 2 times.Take continuously, 3 months was 1 course of treatment.
Therapeutic outcome
Curative effect determinate standard: criterion of therapeutical effect is drafted the efficacy assessment standard of sexual impotence with reference to curative effect grade, the relevant industries standard of " new Chinese medicine clinical research guideline ".Clinical cure: erection can get into vagina naturally and accomplish normal sexual intercourse, and sexual life is satisfied, success rate of sexual intercourse >=75%; Produce effects: erection is with the hand steered entering vaginal intercourse of holding, and sexual life is satisfied in the main, and success rate of sexual intercourse is 50%-74%; Effectively: penile erectile function is treated preceding improvement but can not be got into vagina smoothly, and idol can hand steeredly be held the entering vaginal intercourse, and sexual life is dissatisfied, and success rate of sexual intercourse is 26%-49%; Invalid: with no change or increase the weight of relatively before the treatment, non-access, sexual life is not satisfied at all, and success rate of sexual intercourse is less than 25%.
Statistical method: use SPSS13.0 statistics software; Calculating chart is represented with
; Relatively check between group with user documents (shipped with equipment) t; Enumeration data is used chi-square criterion, and there is statistical significance P＜0.05 for difference.
Efficacy analysis: after treating 1 course of treatment, observation group's clinical cure rate and total effective rate all are higher than matched group as a result, and two groups have significant difference, P＜0.05.For details see attached table 2.
2 liang of groups of subordinate list impotence treatment effect comparison
Clinical implementation example 3: safety testing
Test method
The test crowd: in order to observe this medicine the normal human is had avirulence, we select 40 examples (average 32 ± 5.9 years old of age) healthy premenopausal volunteers (except gestation or the women breast-feeding their children), adopt self cross-reference form.
Instructions of taking: every day 3 times, each 4-6 grain, every 0.45 gram, one after each meal, continuous 3 weeks.Medicament capsule is nourished extra large Pharmaceutical Co by Jiangsu and is provided.
Observation index
The safety observation index mainly comprises total protein TP, albumin A LB, darling renal function (glutamic oxaloacetic transaminase, GOT AST, glutamate pyruvate transaminase ALT; Blood urea nitrogen BUN, inosine CRE), blood glucose GLU, blood fat (T-CHOL TC; Triglyceride TG, HDL-C HDL-C), Hb H GB; Erythrocyte RBC, leukocyte WBC urinates ten.
Result of the test
Tried to observe achievement data through statistical procedures there was no significant difference (P ﹥ 0.05) before and after the volunteer.
Observed result for details see attached table 3.
Subordinate list 3 safety indexes detection case
Claims (8)
1. medicine that improves fast sperm quality and sexual function is characterized in that it is to be prepared from the following raw medicaments in portion by weight thing:
Fructus Lycii 6-60 part Herba Epimedii 6-60 part Radix Polygoni Multiflori 6-60 part Radix Salviae Miltiorrhizae 6-60 part
Cortex Acanthopancis 3-45 part Semen Cuscutae 6-60 part Radix Ginseng 3-45 part Radix Glycyrrhizae 6-36 part
Fructus Schisandrae Chinensis 6-60 part.
2. improve the medicine of sperm quality and sexual function according to claim 1 fast, it is characterized in that: the weight portion of said each raw material of Chinese medicine composition is:
Fructus Lycii 10-45 part Herba Epimedii 10-45 part Radix Polygoni Multiflori 10-50 part Radix Salviae Miltiorrhizae 10-50 part
Cortex Acanthopancis 10-35 part Semen Cuscutae 10-50 part Radix Ginseng 10-30 part Radix Glycyrrhizae 10-30 part
Fructus Schisandrae Chinensis 10-36 part.
3. the medicine of a kind of according to claim 1 quick raising sperm quality and sexual function is characterized in that adopting the pharmaceutics of Chinese drugs common process to process capsule.
4. the medicine of a kind of according to claim 1 quick raising sperm quality and sexual function is characterized in that adopting the pharmaceutics of Chinese drugs common process to process tablet.
5. the medicine of a kind of according to claim 1 quick raising sperm quality and sexual function is characterized in that adopting the pharmaceutics of Chinese drugs common process to process powder or granule.
6. the medicine of a kind of according to claim 1 quick raising sperm quality and sexual function is characterized in that adopting the pharmaceutics of Chinese drugs common process to process watered pill, honey pill agent, water-honeyed pill, concentrated pill or drop pill.
7. the medicine of a kind of according to claim 1 quick raising sperm quality and sexual function is characterized in that adopting the pharmaceutics of Chinese drugs common process to process oral liquid.
8. the medicine of a kind of according to claim 1 quick raising sperm quality and sexual function is characterized in that adopting the pharmaceutics of Chinese drugs common process to process medicinal tea.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104873594A (en) * | 2014-02-28 | 2015-09-02 | 曾正 | Traditional Chinese medicine liquor for treating male kidney deficiency |
| CN106421601A (en) * | 2016-10-25 | 2017-02-22 | 孙光周 | Traditional Chinese medicine potion for treating teratospermia and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1119117A (en) * | 1995-07-22 | 1996-03-27 | 万乙妙 | Dachengzhuangyang wine for strengthening yang |
| CN1370457A (en) * | 2001-02-23 | 2002-09-25 | 梁晨 | Health food |
| CN102475800A (en) * | 2010-11-27 | 2012-05-30 | 叶奉奇 | Tablets used for controlling aspermia infertility |
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2012
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1119117A (en) * | 1995-07-22 | 1996-03-27 | 万乙妙 | Dachengzhuangyang wine for strengthening yang |
| CN1370457A (en) * | 2001-02-23 | 2002-09-25 | 梁晨 | Health food |
| CN102475800A (en) * | 2010-11-27 | 2012-05-30 | 叶奉奇 | Tablets used for controlling aspermia infertility |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104873594A (en) * | 2014-02-28 | 2015-09-02 | 曾正 | Traditional Chinese medicine liquor for treating male kidney deficiency |
| CN106421601A (en) * | 2016-10-25 | 2017-02-22 | 孙光周 | Traditional Chinese medicine potion for treating teratospermia and preparation method thereof |
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