CN104958727B - A kind of Chinese medicine composition for treating the childhood asthma paracmasis and its application - Google Patents

Abstract

The present invention relates to a kind of Chinese medicine composition for treating the childhood asthma paracmasis, and it is made up of the bulk drug of following parts by weight：48 parts of semen brassicae, 48 parts of corydalis tuber, 24 parts of the root of Dahurain angelica, 24 parts of the root of gansui, 24 parts of asarum, 2 20 parts of ginger, 2 20 parts of cloves, 2 20 parts of Chinese cassia tree.The invention further relates to application of the above-mentioned composition in the childhood asthma paracmasis is treated.Advantage is：1st, preparation technology is simple, total effective rate is high, easy to use；2nd, it is horizontal to reduce serum EOS, mitigates chronic inflammation in bronchus, effectively mitigates the occurrence and development of asthma；3rd, improve infant lung function index, make the reduction of infant air flue internal resistance, reduce asthma attack degree；4th, infant syndrome integral is reduced, asthma attack frequency is reduced, significantly improves infant quality of life, the adjustment biased constitution of infant is played a role；5th, hurtless measure, have no toxic side effect, delay asthma attack and mitigate attack degree, improve patients ' life quality.

Description

A kind of Chinese medicine composition for treating the childhood asthma paracmasis and its application

Technical field

The present invention relates to technical field of traditional Chinese medicines, is a kind of Chinese medicine composition for treating the childhood asthma paracmasis specifically And its application.

Background technology

Bronchial astehma (bronchial asthma) is that (such as acidophil, mast cell, T lymphs are thin by various kinds of cell Born of the same parents, neutrophil leucocyte and human airway epithelial cells etc.) and the chronic airway inflammation illness that participates in jointly of cellular component.In recent years, prop up The incidence of disease of san bronchial asthma worldwide has the trend risen year by year, and developed country is higher than developing country, and city is higher than Rural area, and have obvious genetic predisposition.Chinese children asthma cooperative groups organized national children twice in nineteen ninety and 2000 Asthma prevalence epidemiology survey, is as a result shown, the average illness rate of childhood asthma is risen between 1.54%, 10 years by 0.91% Averagely rise 64.84%.Whole nation third time in 2010 finds 0-14 year childhood asthma illness rate in the investigation to 400,000 children Up to 3.01%, 50% was added compared with 2000.Asthma have a strong impact on while infant physical and mental health also brought to parent it is huge Financial burden and stress.

Treatment of the doctor trained in Western medicine to bronchial astehma is divided into acute attack stage and paracmasis.Stage of attack, medicine mainly played rapid recovery Effect, as long acting β_2 agonistics, glucocorticoid, theophylline corrosion inhibiter, antihistamine drug, leukotriene modifer and color are sweet Sour sodium etc..Paracmasis medicine mainly plays long-term control action, such as short-acting broxaterol, glucocorticoid, leukotriene regulation Agent, theophylline and anticholinergic agents etc..Treatment of the Western medicine to asthma achieves very big effect, but the state of an illness is easily repeatedly and the course for the treatment of It is long, and enteron aisle adverse reaction and the attached effect of Amplatzer duct occluder etc. can be produced.External treatment of traditional Chinese medicine shows to the equal curative effect of each phase treatment of asthma Write.Theory of traditional Chinese medical science thinks " not disease preventing and treating ", and theoretical foundation is provided to Asthma in Remission Stage prevention, mitigation asthma attack for the traditional Chinese medical science. Qing Dynasty doctor Zhang Lu is theoretical according to " treating winter disease in summer ", " taking good care of YANG in spring and summer ", initiative dog days plastering therapy treatment asthma,《Zhang Shi is cured It is logical》Described in, semen brassicae, corydalis tuber, the root of gansui, asarum, Moschus are adjusted in ginger juice in dog days, it is certain to be applied to indwelling on acupuncture point Time, it can make " old complaint is gone ".

The traditional Chinese medical science is also proposed the application of a variety for the treatment of children with asthma paracmasises at present, for example, Chinese patent literature 201410265894.7, a kind of outer patch for being used to treat catabasis of bronchitis asthma disclosed in 2014 days for announcing September 17 days is answered Prescription thing and its preparation method and application, it is made up of the prepared slices of Chinese crude drugs of following parts by weight of raw material：Semen brassicae 6-12 parts, asarum 1-3 parts, Rhizoma Arisaematis (processed) 6-12 parts, processed radix kansui 2-5 parts, corydalis tuber 6-12 parts, agalloch eaglewood 3-6 parts, Chinese cassia tree 3-6 parts, psoralea corylifolia 6-12 parts； Preparation method：(1) medicine mixes, low temperature drying, crushes, and crosses 60-100 mesh sieves；(2) CMC solution is prepared；(3) glycerine, Ni Bo are added The golden ethyl ester of that, azone；(4) 1 is pressed:3 ratios are mixed with medicinal powder lotion；(5) heat, nonwoven cloth bag, stripping and slicing.Chinese patent literature 201210003421.0, disclose a kind of Chinese medicine magnetic of the treatment asthma for human acupoint application July 4 2012 day for announcing Outer emplastrum is treated, including：Semen brassicae 10-30, corydalis tuber 10-30, root of gansui 10-20, moxibustion asarum 10-20, moxibustion Chinese ephedra 5-15, dried pinellia 5-15, moxibustion radix glycyrrhizae 5-10, moxibustion tuber of stemona 10-20, Chinese cassia tree 5-10, lepidium seed 5-10, ginger juice 60-80, moxibustion Chinese honey locust 10-15, Moschus 1- 1.5th, arisaema cum bile 10-15, bulbus fritillariae cirrhosae 10~20, earthworm 10~20, borneol 1~5, semen armeniacae amarae 10~20, Cynanchum glaucescens 10~20, process money Coltsfoot 10~20.Foregoing invention has a certain curative effect for Asthma in Remission Stage, but these medicines still have that flavour of a drug are more, prepare work The shortcomings that skill is complicated, therapeutic effect is not good enough.Therefore, need that a kind of flavour of a drug are less, raw material are easy to get, preparation technology is simple and treat badly The medicine of positive effect, and this kind of medicine has not been reported.

The content of the invention

The purpose of the present invention is to be directed to deficiency of the prior art, there is provided a kind of Chinese medicine group for treating the childhood asthma paracmasis Compound.

Another purpose of the present invention is to provide the purposes of above-mentioned Chinese medicine composition.

Another purpose of the present invention is to provide above-mentioned Chinese medicine composition in the preparation method for preparing application.

To achieve the above object, the present invention adopts the technical scheme that：

A kind of Chinese medicine composition for treating the childhood asthma paracmasis, it is characterised in that it is by the raw material of following parts by weight Medicine is made：Semen brassicae 4-8 parts, corydalis tuber 4-8 parts, root of Dahurain angelica 2-4 parts, root of gansui 2-4 parts, asarum 2-4 parts, ginger 2-20 parts, cloves 2-20 parts, Chinese cassia tree 2-20 parts.

Described Chinese medicine composition is made up of the bulk drug of following parts by weight：Semen brassicae 5-7 parts, corydalis tuber 5-7 parts, the root of Dahurain angelica 3 parts, 3 parts of the root of gansui, 3 parts of asarum, ginger 2-10 parts, cloves 2-10 parts, Chinese cassia tree 2-10 parts.

Described Chinese medicine composition is made up of the bulk drug of following parts by weight：6 parts of semen brassicae, 6 parts of corydalis tuber, 3 parts of the root of Dahurain angelica, 3 parts of the root of gansui, 3 parts of asarum, ginger 2-10 parts, cloves 2-10 parts, Chinese cassia tree 2-10 parts.

Described Chinese medicine composition is made up of the bulk drug of following parts by weight：6 parts of semen brassicae, 6 parts of corydalis tuber, 3 parts of the root of Dahurain angelica, 3 parts of the root of gansui, 3 parts of asarum, 10 parts of ginger, 10 parts of cloves, 10 parts of Chinese cassia tree.

To realize above-mentioned second purpose, the present invention adopts the technical scheme that：

As above application of any described Chinese medicine composition in the medicine for preparing the treatment childhood asthma paracmasis.

The medicine is used to reduce childhood asthma paracmasis patients serum EOS levels, reduces inflammatory cell infiltration in air flue, Mitigate chronic inflammation in bronchus.

State medicine to be used to reduce childhood asthma paracmasis Pulmonary Function index, reduce air flue internal resistance, improve pulmonary ventilation Function.The lung function index is PEF values.

The medicament of described medicine is application.

The described noon in dog days that is applied to is applied by ion-introduction therapy in patient's bilateral Dingchuan, feishu, region below the heart acupuncture point Patch treatment.

To realize above-mentioned 3rd purpose, the present invention adopts the technical scheme that：

The preparation method applied as described above, comprises the following steps：

A) medicine is weighed by weight, and mustard seed, corydalis tuber, the root of Dahurain angelica, the root of gansui, asarum are ground into medicinal powder；

B) by ginger crush, the medicinal powder in step a is modulated into pasty state with ginger juice and does patent medicine cake；

C) cloves, Chinese cassia tree are ground into medicinal powder, are spread on medicine cake and skin contact；Described cloves, Chinese cassia tree mass ratio are 1:1。

Semen brassicae：The property of medicine is pungent, temperature.Attach to the lung and stomach meridians, effect is warming lung and reducing phlegm, profit gas dissipating bind, removes obstruction in channels to relieve pain.It is cold for treating Phlegm stops up lung, and cough and asthma is uncomfortable in chest, cloudy subcutaneous ulcer streamer, the card such as extremity numbness, painful swelling of joints.《Compendium of Materia Medica》Call its " sharp gas slit phlegm, except cold warm In, dissipate swollen analgesic.Control asthma to cough gastric disorder causing nausea, numbness wood tinea pedis, all pains of muscles and bones waist section.”《Medicineization justice》：" semen brassicae ... row is very It is prompt ... ... current very sharp, knot phlegm is specially opened, phlegm, which belongs to hot person, to be solved, and belonging to cold person can dissipate.Phlegm is outside flesh side film, and non-this does not reach, in four limbs Two sides of body, non-this is obstructed ..., the sincere sharp wide chest god agent of gas." semen brassicae curative effect is accurate rapidly, the wide chest of slit phlegm warm lung simultaneously, for we Monarch drug in a prescription.

Corydalis tuber：The property of medicine is pungent, bitter, temperature.The thoughts of returning home, liver, the spleen channel.Effect blood-activating and qi-promoting relieves pain.《Compendium of Materia Medica》：" corydalis tuber, Can the stagnation of the circulation of vital energy in promoting circulation of blood, stasis in gas, therefore specially control all pains up and down all over the body is simply fantastic among.Lid corydalis tuber promoting blood circulationization gas, First product medicine.”《Thunder God steeps moxibustion opinion》：" pained to be intended to extremely, speed, which is looked for, prolongs recklessly." corydalis tuber not only entered gas but also entered blood, can blood system qi leel be total to Control, be monarch drug in a prescription altogether with semen brassicae, the effect of row warming spleen and stomach for dispelling cold relieves pain.

The root of Dahurain angelica：The property of medicine is pungent, temperature.Return lung, spleen, stomach.Effect expelling wind and clearing away cold, sensible analgesic.For treating cold, head Bitterly, dentalgia, nasosinusitis, arthralgia pain due to rheumatism etc..《Compendium of Materia Medica》Say：" nasosinusitis, nosebleed epistaxis, dentalgia, pain in the supra-orbital bone are controlled, big intestines wind is secret, urine Bleeding, the dizzy fortune of married woman's blood wind, regurgitation tell food；Solve arsenic poison, snakebite, knife arrow metal-inflicted wound.”《The southern regions of the Yunnan Province book on Chinese herbal medicine》Say：" dispel skin migration it Wind, only the cold stomachache of stomach is cold bitterly, whole body cold-dampness pain." radix angelicae is used as the minister materials medicine auxiliary monarch drug in a prescription row pungent-warm cold dispelling effect.

The root of gansui：The property of medicine is bitter, trembles with fear；It is poisonous.Return lung, kidney, large intestine channel.Effect sluices by drink, dispersing swelling and dissipating binds.For treating water Swollen, tympanites, chest side of body stops drinking, wind phlegm epilepsy, sore and toxic.《Pearl sac》Say：" through hydro-thermal ties part, is the panacea of sluicing. In syndrome caused by accumulation of fluid in the thorax, non-this can not remove, therefore Zhong Jing Daxianxiong Tangs use it.”《Medicine reflects》Say：" specially in water-filling, can go directly water knot it If place ... ... stays phlegm to stay drink place food, the hard accumulations of Disorder, can not be by ... ... Gu Shanzhi ... phlegm is against epilepsy, dysphagic ruffian plug." root of gansui Monarch drug in a prescription purgating excessive fluid, dissipation phlegm heresy are aided in for minister.

Asarum：The property of medicine is pungent, warm, slightly poisonous, enters lung, kidney, the heart channel of Hang-Shaoyin.Effect relieving exterior syndrome and dispelling cold, wind-expelling pain-stopping is sensible, warm lung Drink.《Compendium of Materia Medica》Cloud：" asarum, pungent-warm can dissipate, therefore all chill headache due to wind-wetness evil, in the heart phlegm and retained fluid, stagnant gas, frightened epilepsy person, preferably use it. It is pungent to let out lung, therefore the upper gas person of cough due to wind-cold evil preferably uses it.”《Mingyi Bielu》Yan Qineng " broken phlegm, dredging water passages, open chest ... ".《The legendary god of farming Book on Chinese herbal medicine warp》Record this medicine " main cough is inverse ... sharp nine orifices ".The asthma interpretation of the cause, onset and process of an illness is dirty related to lung kidney two, and asarum pungent-warm disperse function goes directly Lung kidney, and complemented each other with other drugs.

Chinese cassia tree：The property of medicine is pungent, sweet, big heat.Return kidney, spleen, the heart, Liver Channel.Effect mends fire supporing yang, warming spleen and stomach for dispelling cold, antalgic, a surname Venting QI-blood, conducting the fire back to its origin.Its it is medicinal first recorded in《Sheng Nong's herbal classic》, top grade is classified as, " Your Majesty's gas cough is inverse ".《The Decoction and Material Medica》：" mend Gate of vitality's deficiency, boosting source of fire for eliminating abundance of yin.”《Book on Chinese herbal medicine is looked for the truth》：It is " big to mend the gate of vitality's mutually fire, Yiyang Zhi Yin.All chronic diseaseses, battalion defend chill, the deficiency of yang Crymodynia ... in spontaneous perspiration, abdomen, because of the cold person of obtaining because stagnant, controlled with this and imitated invariably." Chinese cassia tree dissipate on medicine cake directly contact skin, can Draw all medicines to enter through warm kidney sun, treating heavy cold persistent ailment.

Cloves：The property of medicine is pungent, warm, returns spleen, stomach, lung, kidney channel.Inverse, eliminating cold to stop pain, warming kidney and enhancing yang drop in effect middle benefit gas.《Solar corona Book on Chinese herbal medicine》：" implication is controlled, gastric disorder causing nausea, kidney qi is treated, up-rushing gas syndrome, cloudy pain, establishing-Yang, warms up waist and knee.”《Book on Chinese herbal medicine is just》：" the fast gas of middle benefit gas.Control the part of the body cavity above the diaphragm housing the heart and lungs Hiccup, except stomach cold, to let out dysentery, seven feelings five strongly fragrant." cloves and Chinese cassia tree draw all medicines and enter through playing the effect of warming kidney and enhancing yang cold dispelling altogether altogether.

Ginger：The property of medicine is pungent, warm, return lung, spleen, stomach.Effect inducing sweat and dispelling exogenous evils, warming middle energizer to arrest vomiting, warm lung cough-relieving, solving toxin of fish and crab, Antidote poison.《Haigoushen》Yan Qi：" main phlegm aqueous vapor expires, lower gas；Raw controlled with dry doubling is coughed, and disease during treatment, anti-nausea is not lower to eat.”《Name doctor Do not record》Say：" main cold headache nasal obstruction, cough with dyspnea." modern study find ginger chemical composition contain volatile oil.Will be raw in we Ginger is squeezed the juice coordinating the drug actions of a prescription, remains the property of medicine of ginger pungent-warm, but because its volatilization having help all medicines it is transdermal enter in.

Fei shu cave is the back shu points of lungs, is that the gas of lungs is transfused the acupuncture points on the human body in the small of the back.Belong to urinary bladder channel of foot-Taiyang cave, It is positioned at back, under third dorsal vertebra spinous process, side opens 1.5 cun.Fei shu is located proximate to lung, cures mainly cough, asthma, hemoptysis, nasal obstruction etc. Disease.《Money life》：" it is all to have asthma and heavy breathing person, for by fei shu, ache, is all Miao thorn fei shus, makes moxibustion and be cured invariably.”《Copper people》：" pass Corpse steams labor, and lung withers cough." modern study find acupuncture fei shu can strengthen respiratory function, make pulmonary ventilation volume, pneusomete oxygen consumption Amount increase, hence it is evident that lower airway resistance；And fei shu is improved the effect of immunity, have to many respiratory diseases two-way Adjustment effect.

Gaomang point is urinary bladder channel of foot-Taiyang acupuncture point, is positioned at back, and under fourth dorsal vertebra spinous process, side opens 3 cun.Cure mainly cough, Asthma, night sweat etc..《Prescriptions worth thousand gold》：" region below the heart Yu, without not controlling, master is thin thin deficient, and essence is lost in dream, and upper gas cough is inverse, mad puzzled to forget to miss.” 《Poly- English》：" go mad, forgetful, phlegm disease." cave is wanted frequently as consumptive disease and chronic disease in modern clinic.

DINGCHUAN acupoint belongs to extra nerve points, i.e. points not mentioned in the ancient medical classics, other under the spinous process of the seventh cervical vertebrae of back to open 0.5 cun, cures mainly asthma, coughs, falls Pillow, painful shoulder and back etc., it is the experience cave that treatment cough is panted.Modern study finds that acupuncture DINGCHUAN acupoint can reduce bronchial mucosa and ooze Go out, release bronchial spasm, improve respiratory function.

The invention has the advantages that：

1st, compared with prior art, pharmaceutical preparation of the invention is simple, good effect, easy to use.

2nd, medicine of the invention can reduce the EOS levels of asthmatic children in remission period serum, reduce inflammatory cell leaching in air flue Profit, mitigate chronic inflammation in bronchus, reduce airway hyperreactivity, so as to effectively mitigate the occurrence and development of asthma.

3rd, drug therapy Children with Asthma of the invention can improve infant lung function index, make infant air flue internal resistance Reduce, be effectively improved pulmonary ventilation function, prevention of asthma breaking-out, reduce asthma attack degree.

4th, drug therapy Children with Asthma of the invention, infant syndrome integral can be reduced, reduces asthma attack frequency, Infant quality of life is significantly improved, the adjustment biased constitution of infant is played a role.

5th, medicine hurtless measure of the invention, has no toxic side effect, and can delay asthma attack and mitigate attack degree, improve and suffer from Person's quality of life.

Brief description of the drawings

Accompanying drawing 1 is the treatment group of embodiment 1 and control group Sex distribution com-parison and analysis.

Accompanying drawing 2 is the treatment group of embodiment 1 and control group age distribution com-parison and analysis.

Accompanying drawing 3 is the treatment group of embodiment 1 compared with control group course of disease distributional analysis.

Accompanying drawing 4 is the treatment group of embodiment 1 and disease com-parison and analysis before control group treatment.

Accompanying drawing 5 is the treatment group of embodiment 1 and the pretherapy and post-treatment disease integration com-parison and analysis of control group.

Accompanying drawing 6 is the treatment group of embodiment 1 and the pretherapy and post-treatment PEF values com-parison and analysis of control group.

Accompanying drawing 7 is the treatment group of embodiment 1 and the pretherapy and post-treatment EOS values com-parison and analysis of control group.

Accompanying drawing 8 is the treatment group of embodiment 1 compared with control group total effectses.

Embodiment

The invention will be further elucidated with reference to specific embodiments.It should be understood that these embodiments are merely to illustrate this hair Bright rather than limitation the scope of the present invention.In addition, it is to be understood that after the content of the invention lectured has been read, art technology Personnel can make various changes or modifications to the present invention, and these equivalent form of values equally fall within the application appended claims and limited Fixed scope.

Embodiment 1 treats the preparation (one) of the Chinese medicine composition of childhood asthma paracmasis

6 parts of semen brassicae, 6 parts of corydalis tuber, 3 parts of the root of Dahurain angelica, 3 parts of the root of gansui, 3 parts of asarum, 10 parts of ginger, 10 parts of cloves, Chinese cassia tree 10 Part.

Embodiment 2 treats the preparation (two) of the Chinese medicine composition of childhood asthma paracmasis

4 parts of semen brassicae, 8 parts of corydalis tuber, 2 parts of the root of Dahurain angelica, 4 parts of the root of gansui, 2 parts of asarum, 20 parts of ginger, 2 parts of cloves, Chinese cassia tree 20 Part.

Embodiment 3 treats the preparation (three) of the Chinese medicine composition of childhood asthma paracmasis

8 parts of semen brassicae, 4 parts of corydalis tuber, 4 parts of the root of Dahurain angelica, 2 parts of the root of gansui, 4 parts of asarum, 2 parts of ginger, 20 parts of cloves, 2 parts of Chinese cassia tree.

Embodiment 4 treats the preparation (four) of the Chinese medicine composition of childhood asthma paracmasis

4 parts of semen brassicae, 4 parts of corydalis tuber, 4 parts of the root of Dahurain angelica, 4 parts of the root of gansui, 3 parts of asarum, 12 parts of ginger, 15 parts of cloves, Chinese cassia tree 12 Part.

Embodiment 5 treats the preparation (five) of the Chinese medicine composition of childhood asthma paracmasis

5 parts of semen brassicae, 7 parts of corydalis tuber, 3 parts of the root of Dahurain angelica, 4 parts of the root of gansui, 2 parts of asarum, 10 parts of ginger, 15 parts of cloves, Chinese cassia tree 15 Part.

Embodiment 6 treats the preparation (six) of the Chinese medicine composition of childhood asthma paracmasis

6 parts of semen brassicae, 5 parts of corydalis tuber, 3 parts of the root of Dahurain angelica, 2 parts of the root of gansui, 4 parts of asarum, 17 parts of ginger, 7 parts of cloves, Chinese cassia tree 15 Part.

Embodiment 7 treats the preparation (seven) of the Chinese medicine composition of childhood asthma paracmasis

7 parts of semen brassicae, 7 parts of corydalis tuber, 2 parts of the root of Dahurain angelica, 4 parts of the root of gansui, 3 parts of asarum, 5 parts of ginger, 10 parts of cloves, 6 parts of Chinese cassia tree.

Embodiment 8 treats the preparation (eight) of the Chinese medicine composition of childhood asthma paracmasis

6 parts of semen brassicae, 4 parts of corydalis tuber, 4 parts of the root of Dahurain angelica, 3 parts of the root of gansui, 4 parts of asarum, 10 parts of ginger, 10 parts of cloves, Chinese cassia tree 8 Part.

Embodiment 9 treats the preparation of childhood asthma paracmasis application

A) preparation method：Any described Chinese medicine compositions of Example 1-8, by mustard seed, corydalis tuber, the root of Dahurain angelica, the root of gansui, thin It is pungent to be ground into medicinal powder；

B) by ginger crush, the medicinal powder in step a) is modulated into pasty state with ginger juice and does patent medicine cake；

C) cloves, Chinese cassia tree are ground into medicinal powder, are spread on medicine cake and skin contact.

The clinical research of embodiment 10

1. clinical data

1.1 case sources

18 days-August July in 2014 is collected to go to a doctor during summer dog days within 16th in the attached Yueyang Chinese and Western of Shanghai Univ. of Traditional Chinese Medicine Doctor is with reference to the patient of hospital-based outpatient pediatic clinic, and row applies iontophoresis and the asthmatic children in remission period of MK treatment is total to 64.

1.2 diagnostic criteria

1.2.1 Western medicine diagnostic criteria

With reference to paediatrics branch of Chinese Medical Association pneumatology group revision in 2008《Children with asthma preventing and treating is conventional (tentative) Diagnosis and treatment guide》In relevant content formulate.

(1) recurrent exerbation pant, cough, shortness of breath, it is uncomfortable in chest, more with contact allergen, cold air, physics, chemical irritation, Respiratory tract infection and motion etc. are relevant, often in night and (or) early morning breaking-out or aggravation.

(2) in double lung audibles and it is dispersed in or diffusivity, the wheezing sound based on expiratory phase when breaking out, expiratory phase extends.

(3) above-mentioned symptom and sign effectively or are voluntarily alleviated through anti-treating asthma.

(4) panting, coughing caused by other diseases except, shortness of breath and uncomfortable in chest.

(5) its atypical clinical manifestations person's (such as nothing is substantially panted or wheezing sound), should at least possess following 1：[1] bronchus Provocative test or motion activated experiment are positive；[2] it is confirmed the existence of reversible airflow limitation：1. Bronchodilation Test is positive：Inhale Enter quick-acting β 2 receptor agonists [such as salbutamol (Salutation)] afterwards 15min forced expiratory volume in first second (FEV1) increase >= 12% or 2. anti-treating asthma is effective：After bronchodilators and oral (or suction) glucocorticoid treatment 1-2 weeks, FEV1 increases >=12%；[3] the daily aberration rate (continuous monitoring 1~2 week) 20% of maximum expiratory flow volume (PEF).

Meet the 1-4 articles or the 4th, 5 article of person, asthma can be diagnosed as.

1.2.2 childhood asthma paracmasis diagnostic criteria

With reference to paediatrics branch of Chinese Medical Association pneumatology group revision in 2008《Children with asthma diagnosis and treatment guide (revising within 2008)》In relevant content formulate.

Clinical relieving period is meant to disappear by treatment or untreated symptom, sign, before PFT returns to acute attack Level, and maintain more than 3 months.

1.2.3 traditional Chinese medical science asthma and disease parting

The diagnosis of traditional Chinese medical science asthma and asthenia of pulmonosplenic qi card, syndrome of yang deficiency of spleen and kidney is with reference to New Century higher institutions of Chinese medicine 2004 editions seven-year system programming textbooks《Pediatrics of Chinese Medicine》Formulate.

Traditional Chinese medical science asthma diagnoses normative reference：

(1) there are infancy eczema history, allergies, family's asthma history more；

(2) there is the medical history of recurrent exerbation.Breaking-out is how relevant with some risk factors, such as weather cataclysm, suffers from cold heated, feeds Or some allergins of contact.It is before breaking-out to have the tendencys such as sneeze, nasal obstruction, cough more；

(3) often break out, paroxysm of cough during breaking-out, syndrome characterized by dyspnea is out of breath, wheezing sound in the throat, or even can not lie down, it is irritated not Peace, cyanotic lips；

(4) the lung audible of auscultation of lung two and wheezing sound, obvious, expiratory flow retard during exhaling.If bronchial astehma has secondary Infection, audible and moist rales.

Asthma asthenia of pulmonosplenic qi demonstrate,proves normative reference：More repeated colds, shortness of breath spontaneous perspiration, cough is powerless, the few China of colourless, and god is tired Speech, shape is thin to receive difference, and big loose stool, tongue nature is light, and tongue is thin white, thready and soft pulse.

Asthma syndrome of yang deficiency of spleen and kidney normative reference：Pale complexion, shape is trembled with fear, and limb is cold, and pin is soft powerless, and dynamic then shortness of breath palpitations, abdominal distension is received Difference, diarrhea with loose stool, clear abundant urine, tongue nature is light, and tongue is thin white, and arteries and veins is thin and delicate.

Because of the more pungent-warm diverging medicines of Chinese medicine composition of the present invention, therefore including for syndrome of yin deficiency of lung and kidney type is not considered, only include lung spleen Syndrome of qi deficiency and syndrome of yang deficiency of spleen and kidney

1.3 experiment inclusive criterias

(1) meet the diagnosis of traditional Chinese medical science asthma, and belong to asthenia of pulmonosplenic qi card type and syndrome of yang deficiency of spleen and kidney type；

(2) doctor trained in Western medicine childhood asthma and paracmasis diagnostic criteria are met；

(3) 5-14 year infant, and can coordinate and complete curer；

(4) other underlying diseases of nonjoinder, such as：The purple paralysis of congenital heart disease, diabetes, nephrotic syndrome, anaphylaxis Deng；

(5) inform and agree to participate in this experimenter, guardian signs informed consent form.

1.4 experiment exclusion standards

(1) age is below 5 years old or the patient of more than 14 years old；

(2) symptom, or original symptom sharp deterioration person such as there is heating, coughs, pants in the seizure of disease phase；

(3) the clear and definite heart, liver, kidney illness and nerve, psychosis, malignant tumour, congenital disorders trouble are diagnosed Person；

(4) row application therapy patient at drug allergy, or application acupuncture point to having malignant boil, sore, furuncle and skin injury person；

(5) hormone preparation person was used in nearly two weeks.

1.5 experiment termination criterias

(1) infant compliance is poor, does not complete treatment, or initiative exits this experimenter；

(2) asthma or other diseases breaking-out during clinical treatment, it is impossible to carry out curer；

(3) there is severe allergic reaction or adverse reactions people in patient during clinical research.

1.6 research method

1.6.1 case is grouped

The infant for meeting inclusive criteria is divided into treatment group and control group, sample size is according to formula：N1=N2=12.365 × P (1-P)/δ², typically required according to conventional curative effect and statistics, take equivalence margin δ=0.15, average effectiveness level P= 0.95, being calculated every group needs at least 66, and this research is final to enter 64 cases of group altogether, and by infant according to table of random number point For treatment group, control group.

1.6.2 the selection of medicine

As the application prepared by the Chinese medicine composition of embodiment 1；Menglusitena.

1.6.3 required medicine and equipment manufacturer and lot number

Montelukast sodium chewable tablet (Singulair)：Hangzhou Mo Shadong pharmaceutical Co. Ltds, Chinese medicines quasi-word：4mg： J20130048；5mg：J20130054；

Semen brassicae, corydalis tuber, the root of Dahurain angelica, the root of gansui, asarum, ginger, cloves, Chinese cassia tree：Shanghai Hua Ying pharmaceutcal corporation, Ltds, HY2013111301；All Chinese medicines are ground by Yueyang hospital pharmacy and prepared, and fresh ginger juice is tuned into pasty state, and the treatment same day prepares patent medicine Cake.

NPD5AS type ion introducing apparatus：2001-0034 is permitted in Nanjing Bao Yuan electronic technology research institute, Soviet Union's food medicine prison tool production Number；

Mini peak flow meter：PAPI Mini-Wright AFS PEAK FLOW METER；

Routine analysis of blood instrument determines：Sysmex XS-800I.

1.6.4 acupuncture point selects

Bilateral Dingchuan, feishu, region below the heart are chosen for convenience of operation according to science of acupuncture and moxibustion acupunctare-point locating principle.

1.6.5 treatment group specifically applies the time

Treatment group since first day (on July 18th, 2014) of dog days to last day (on August 16th, 2014), from Monday Pasted to the next day Saturday one, period of the day from 11 a.m. to 1 p.m for most containing of yang-energy in selecting one day, i.e. at 11 points at noon at 1 point in afternoon；Do a full dog days totally 9 Secondary, the application course for the treatment of terminates.

1.6.6 application therapy method

Infant prostrate exposed skin, medicine cake is placed directly within acupuncture point (6), above puts hygenic towelette, place battery lead plate, connection Ion introducing apparatus.Using " importing " pattern, " intensity " (situation regulation is resistant to according to patient) and " time " (20 minutes) are mixed up.When Machine removes battery lead plate and medicine cake after sending the prompt tone for the treatment of end, wipes infant skin to cleaning.

1.6.7 Menglusitena treatment method

Treatment group and control group are taken MK from dog days' daystart and amounted to 3 months；Wherein >=6 years old infant 5mg, Qn, orally；5 years old infant 4mg, Qn, orally.

1.7 points for attention

Dry skin cleaning at application is kept after application therapy terminates in 2 hours.As local tide occurs in skin after application Red or pigmentation, slight itch are normal phenomenon, can continual cure.If there is cutaneous pain, water in application or after application Steep, fester, violent itch, stopping application immediately, paying attention to protecting the surface of a wound, avoid scratching caused infection, and see a doctor in time.Application The food, fasting shrimp crab seafood etc. such as period fasting is raw and cold, pungent, fried easily hair food, the product of the rich easily raw phlegm wet of fasting.Treatment Middle attention wind sheltering is cold, hot summer weather.Stop applying if asthma attack in the application course for the treatment of, timely use asthma controller medications, if necessary To hospital admission.

1.8 observation index

The new Chinese medicine guideline of clinical investigations 2002 editions formulated with reference to National Drug Administration, new Chinese medicine is controlled Treat the guideline of clinical investigations for disease of roaring：

(1) syndrome integral of 6 months before treatment and after treatment：

Main syndromes integrate：

Asthma attack number (half a year)：No. 00 point of meter；No. 12 points of meter；No. 24 points of meters；No. 36 points of meters；

Panted during breaking-out degree：Divide without shortness of breath meter 0；Shortness of breath, which is panted, after aggravating activities counts 2 points；After cough or slightly shortness of breath after activity Pant and count 4 points；Shortness of breath, which is panted, during rest can not lie down 6 points of meter；

Usually times of common cold：>=60 days No. 1 time 0 point of meter；40-60 days No. 1 time 2 points of meter；30-40 days No. 1 time 4 points of meter；>=30 days 1 time 6 points of meter；

Usually nasal obstruction, rhiocnesmus, sneeze：Normal 0 point of meter；Daily 1-3 2 points of meter；4 points of meter more than 4 times a day；Daily frequency is made 6 points of meter；

Secondary syndrome integral：

Shortness of breath hidrosis：Normal 0 point of meter of perspiring after the flat activity of gas；Clothing meter 1 is made after aggravating activities soaked with sweat greatly to divide；Slightly profuse sweating after activity Wet clothing meter 2 divides；Clothing meter 3 is made during rest soaked with sweat greatly to divide；

Spiritlessness and sparing of words：Brace up and count 0 point；There is sense of fatigue meter 1 to divide；There is fatigue and limbs fatigue meter 2 divides；Limbs fatigue is thought Sleep lazy 3 points of speech meter；

The thin difference of receiving of shape：Stomach, which is received, normally counts 0 point；Appetite does not subtract but feels dull 1 point of meter；Appetite difference appetite reduces by 1/3 2 points of meter； Without appetite；Appetite reduces by >=1/2 3 points of meter；

Lustreless complexion：Complexion is glossy to count 0 point；Complexion is slightly owed gloss meter 1 and divided；Complexion is owed gloss meter 2 and divided；Dim complexion pool 3 points of meter；

Receive poor loose stool：Stomach, which is received, to count 0 point without loose stool；Appetite does not subtract, but feels that dull loose watery stool meter 1 divides；Appetite difference stool Dilute half congealed 2 points of meter；Divide without appetite loose watery stool meter 3；

The cold limb of shape is cold：Warm 0 point of the meter of limbs；Cold 1 point of the meter of chronognosis body；Not warm 2 points of the meter of four skins of body cold；Fear cold skin Cool happiness is wrapped up in clothing meter 3 and divided；

Pale complexion：Have rosy cheeks and count 0 point；Simple and unadorned 1 point of the meter of pale white complexion；Mian Se Koushi count 2 points in vain；Pale complexion meter 3 divides

It is dynamic then pant：Breath steadily counts 0 point；Shortness of breath, which is panted, after aggravating activities counts 1 point；Shortness of breath is panted meter 2 after normal activity Point；Pause shortness of breath after activity to pant 3 points of meter；

(2) PFT End--tidal PCO_2 (PEF)：Compare PEF values before treatment and after treating 6 months.

(3) eosinophil count (EOS)：Compare EOS values before treatment and after treating 6 months.

1.9 curative effect determinate standard

The new Chinese medicine guideline of clinical investigations 2002 editions formulated with reference to National Drug Administration, new Chinese medicine is controlled Treat the guideline of clinical investigations of asthma：

(1) clinic control (recovery from illness)：PEF incrementss ＞ 35%；Clinical symptoms, sign disappears or basic disappearance, symptom product Divide and decline >=95%；

(2) it is effective：PEF incrementss are between 25%-35%；Clinical symptoms, sign significantly take a turn for the better, and symptom integral decline >= 70%；

(3) effectively：PEF incrementss are between 15%-24%；Clinical symptoms, sign make moderate progress, and symptom integral decline >= 30%；

(4) it is invalid：PEF is without improvement, or even reduces；Clinical symptoms, sign are reduced without improvement, or even aggravation, symptom integral< 30%.

1.10 statistical analysis technique

Data are analyzed, with P using Excel typings, arrangement using SPSS17.0 software statistics<0.05 is that difference has statistics Learn meaning.Measurement data, if data Normal Distribution, represented using mean ± standard deviation；Enumeration data uses frequency and hundred Divide to form and represent.Compare between measurement data group and examined using t.Enumeration data uses Chi-square Test.

2. result of study

2.1 general clinical datas

Through screening, 64 observation infants are all from Yueyang hospital-based outpatient pediatic clinic case, meet inclusive criteria.Wherein Treatment group 33, because traditional Chinese medicinal cake allergy exits treatment 1, do not adhere to that taking Menglusitena treats 1, finally includes research Totally 31, expulsion rate 6.06%.Control group 31, because follow-up missing comes off 1,30 is finally studied altogether, expulsion rate 3.2%.

2.2 harmonious analyses

2.2.1 Sex distribution

This investigates 61 infants altogether, the people of boy student 33, the people of schoolgirl 28, two groups of sex composition no difference of science of statistics (be shown in Table 1 and Fig. 1).

The Sex distribution com-parison and analysis of table 1

Note：Through χ²Examine, P ＞ 0.05,0.05 inspection level is equal to according to α, two group differences are not statistically significant.

2.2.2 age distribution

Two groups of age recklings 5 years old, the maximum 13 years old, two groups of age distribution no difference of science of statistics (being shown in Table 2 and Fig. 2).

The age distribution com-parison and analysis of table 2

Note：Through independent samples t-test, P ＞ 0.05,0.05 inspection level, two groups of no significant differences are equal to according to α.

2.2.3 course of disease com-parison and analysis

The course of disease most short person's half a year, most elder 7 years, two groups of course of disease distribution no difference of science of statistics (being shown in Table 3 and Fig. 3).

The course of disease com-parison and analysis of table 3

Note：Through χ²Examine, P ＞ 0.05, two groups of no significant differences.

2.2.4 disease integration compares before two groups of treatments

Syndrome integral treatment group is 14.13 ± 3.030 before treatment, and control group is 12.73 ± 3.912, two groups of tcm syndromes Integration has comparativity (being shown in Table 4 and Fig. 4) without significant difference.

Disease integration compares before table 4 is treated

Note：Examined through t, P ＞ 0.05, two groups of no significant differences.

Shown through examining：There was no significant difference (P ＞ 0.05) for syndrome integral before two groups of sex, age, the course of disease and treatment.

2.3 treatment results are analyzed

2.3.1 two groups of pretherapy and post-treatment disease integrations compare

Two groups of pretherapy and post-treatment TCM syndrome integral contrasts, comparing difference is statistically significant (P in two groups of groups< 0.01) before, the TCM syndrome integration after treatment is significantly less than treatment；Comparing difference has system between group after treatment group and control group treatment Meter learns meaning (P<0.05), and improvement of the treatment group to disease total mark is better than control group (being shown in Table 5 and Fig. 5).

The pretherapy and post-treatment syndrome integral com-parison and analysis of 5 two groups of table

Group	Before treatment	After treatment	t
				Treatment group	14.13±3.030	6.68±2.535	16.767
Control group	12.73±3.912	7.17±3.860	9.789

Note:Through paired t-test, more equal P ＜ 0.01 in treatment group and control group group；Compare through independent samples t-test, two groups are controlled Compare after treatment between group, t=2.622, P=0.01, P ＜ 0.05.Two groups of therapies can reduce infant syndrome integral, and treatment group is excellent In control group.

2.3.2 two groups of pretherapy and post-treatment PEF values com-parison and analysis

Pretherapy and post-treatment PEF values compare in treatment group and control group group,<0.05, two groups have improvement to PEF values；Treatment PEF values compare between group after group and control group treatment, P<0.05, difference is statistically significant, and treatment group is better than to PEF value improvement Control group (see compared with 6 and Fig. 6).

The pretherapy and post-treatment PEF values com-parison and analysis of 6 two groups of table

Group	PEF values before treatment	PEF values after treatment	t	P
					Treatment group	316.21±17.811	333.79±12.688	-5.753	0.000
Control group	315.00±16.330	321.61±18.158	-2.163	0.040

Note：Compare through paired t-test, the relatively equal P ＜ 0.05 of PEF values in treatment group and control group group；Through independent samples t-test ratio Compared with PEF values compare between group after treatment group and control group treatment, t=0.014, P ＜ 0.05.Two groups of therapies can improve infant lung Function PEF is horizontal, and treatment group is better than control group.

2.3.3 two groups of pretherapy and post-treatment EOS values com-parison and analysis

Pretherapy and post-treatment EOS values compare in treatment group and control group group, equal P<0.05, two groups have improvement to EOS values；Treatment EOS values compare between group after group and control group treatment, P<0.05, difference is statistically significant, it is believed that two groups different to EOS value differences to have Statistical significance, and treatment group is better than control group (being shown in Table 7 and Fig. 7) to the improvement of EOS values.

The pretherapy and post-treatment EOS values com-parison and analysis of 7 two groups of table

Group	EOS values before treatment	EOS values after treatment	t	P
					Treatment group	0.243±0.485	0.194±0.060	6.301	0.000
Control group	0.243±0.066	0.218±0.061	2.702	0.012

Note:Compare through paired t-test, two groups are compared EOS value P ＜ 0.05 before and after treatment in group；Compare through independent samples t-test, EOS values compare between group after two groups of treatments, t=2.089, P=0.041, P ＜ 0.05.Two groups of therapies can improve infant serum EOS Level, and treatment group is better than control group.

2.3.4 two groups of total effectses com-parison and analysis

Two groups of total effectses compare P=0.023, P<0.05, two groups of differences are statistically significant, and treatment group's total effective rate 96.8%, control group total effective rate 76.7%, treatment group's total effective rate is due to control group (being shown in Table 8 and Fig. 8).

8 two groups of total effectses of table compare

Note：Through χ²Examine, P ＜ 0.05, two groups of differences are statistically significant.Two groups of total effectses compare, and treatment group is always effective Number is more than control group, and invalid number is less than control group.

3. treating winter disease in summer application ion-introduction therapy treatment asthma Exploration of Mechanism

The improvement result of 3.1 pairs of PFTs

Bronchial astehma causes airway hyper-reaction, makes air flue flow limitation, is chronic airway inflammation disease.China《Branch San bronchial asthma guideline of prevention and treatment》With《Global asthma preventing and treating》Goldstandard using pulmonary function detection as asthma.Lung function tests is to build The measure of the respiratory function stood on the basis of clinical physiology, available for clarifying a diagnosis, mutually differentiates with Other diseases, evaluates branch gas The order of severity of pipe asthma, formulation and adjustment for treating asthma scheme provide foundation.PEF (PFT End--tidal PCO_2) can be with The patency of page turning air flue, the coincident with severity degree of condition for judging asthma and therapeutic effect etc..One of diagnostic criteria of bronchial astehma It is PEF daily aberration rate.

This result of study is shown：Ion-introduction therapy and medicine co-therapies children with bronchial asthma disease, treatment are applied with treating winter disease in summer Lung function index PEF values are significantly improved before relatively treating, and contrast before and after treatment difference has statistics compared with pre-treatment within 6 months afterwards Learn meaning (P<, and treatment group and the statistically significant (P of simple western medicine control group comparing difference 0.05)<0.05) winter disease, is prompted Xia Zhi application ion-introduction therapy treatment children with bronchial asthma disease can improve its PEF levels, and it is same to reduce the improvement pulmonary ventilation of infant airway resistance Can, asthma attack number and attack degree are reduced, improves the quality of life of infant.

The influence of 3.2 pairs of chronic airway inflammations

The air flue basic pathological changes of Bronchial Asthmas are exactly the infiltration of inflammatory cell, and modern medicine finds various points The asthma common etiology feature in type various periods is exactly airway allergic inflammation, and the air flue of Bronchial Asthmas is in all the time Chronic inflammatory state, EOS (serum acidophic cell) are a kind of important inflammatory mediators in airway inflammation forming process, Airway inflammation activity is reflected, is the most important Histopathological Characteristics of air flue mucous membrane infiltration.The main clinical manifestation of asthma It is exactly airway obstruction, can be alleviated by rest or various treatment obstructive symptoms, patient's pulmonary ventilation function is improved, but air flue is scorching Disease is not disappeared, and pulmonary function detection can not show the degree of asthma patient airway hyperreactivity inflammation.Serum EOS reaction gases Road course inflammatory activity, the treatment of asthma can be instructed to evaluate therapeutic effect by detecting serum EOS levels.

This result of study is shown：Serum EOS values are relatively treated compared with pre-treatment within 6 months after treatment group and control group treatment Preceding reduction, the statistically significant (P of contrast before and after treatment difference<0.05), application and treated with combined medication compare with simple western medicine Statistically significant (the P of group comparing difference<0.05) treating winter disease in summer application ion-introduction therapy and Western medicine therapeutic alliance, are prompted to roaring Reduction horizontal asthma infant serum EOS is better than simple western medicine group, and application ion-introduction therapy can mitigate patient airway inflammatory cell Infiltration, reduce airway allergic inflammation, effectively prevent and treat asthma.

4. conclusion

(1) the study show that treating winter disease in summer application ion-introduction therapy can reduce the EOS water of asthmatic children in remission period serum It is flat, inflammatory cell infiltration in air flue is reduced, mitigates chronic inflammation in bronchus, reduces airway hyperreactivity, so as to effectively mitigate The occurrence and development of asthma.

(2) the study show that treating winter disease in summer application ion-introduction therapy treatment Children with Asthma can improve infant lung work( Energy index, make the reduction of infant air flue internal resistance, be effectively improved pulmonary ventilation function, prevention of asthma breaking-out, reduce asthma attack degree.

(3) the study show that treating winter disease in summer application ion-introduction therapy treatment Children with Asthma, can reduce infant card Integration is waited, asthma attack frequency is reduced, significantly improves infant quality of life, the adjustment biased constitution of infant is played a role.

(4) treating winter disease in summer application ion-introduction therapy hurtless measure, has no toxic side effect, and can delay asthma attack and mitigate hair Make degree, improve patients ' life quality.

The contrast test of embodiment 11

1. general information

Collect during July in 2014 18 days-August summer dog days on the 16th in the infant 150 of hospitals of Shanghai Pediatric Clinic, with Machine is divided into 5 groups, every group 30；Syndrome integral is statistically analyzed before the sexes of four groups of infants, age, the course of disease, treatment, no statistics Meaning, there is comparativity (P>0.05).Childhood asthma paracmasis diagnostic criteria, observation index, curative effect determinate standard, medicament sources And equipment is same as Example 1.

Treatment group one is using as the application prepared by the Chinese medicine composition of embodiment 2, from first day (in July, 2014 of dog days 18 days) start to last day (on August 16th, 2014), pasted from the next day Monday to Saturday one, yang-energy is most contained in selecting one day The period of the day from 11 a.m. to 1 p.m, i.e. at 11 points at noon at 1 point in afternoon；Do full dog days totally 9 times；Medicine cake is placed directly within acupuncture point (6), above put wet Paper handkerchief, battery lead plate is placed, connect ion introducing apparatus, imported 20 minutes.Treatment group two uses the Chinese medicine composition institute by embodiment 3 The application of preparation, to last day (on August 16th, 2014) since first day (on July 18th, 2014) of dog days, from Monday to The Saturday next day one, pastes, period of the day from 11 a.m. to 1 p.m for most containing of yang-energy in selecting one day, i.e. at 11 points at noon at 1 point in afternoon；Do a full dog days totally 9 It is secondary, medicine cake is placed directly within acupuncture point (6), above puts hygenic towelette, places battery lead plate, connects ion introducing apparatus, is imported 20 minutes. The infant for the treatment of group three is used to apply：Take 10 parts of ginger to squeeze the juice, 6 parts of semen brassicae, 6 parts of corydalis tuber, 3 parts of the root of gansui, asarum 3 are ground into Medicinal powder, it is modulated into thick paste with ginger juice and does patent medicine cake；10 parts of cloves, 10 parts of Chinese cassia tree are ground into medicinal powder, are spread on medicine cake and skin Contact surface, to last day (on August 16th, 2014) since first day (on July 18th, 2014) of dog days, from Monday to Saturday The next day one paste, the period of the day from 11 a.m. to 1 p.m that yang-energy is most contained in selecting one day, i.e. at 11 points at noon at 1 point in afternoon；Do full dog days totally 9 times；Will Medicine cake is placed directly within acupuncture point (6), above puts hygenic towelette, places battery lead plate, connects ion introducing apparatus, is imported 20 minutes.Treatment Four infants of group are used to apply：10 parts of ginger is taken to squeeze the juice, by 6 parts of semen brassicae, 6 parts of corydalis tuber, 3 parts of the root of Dahurain angelica, 3 parts of the root of gansui, 3 parts of asarum Medicinal powder is ground into, being modulated into thick paste with ginger juice does patent medicine cake, to last since first day (on July 18th, 2014) of dog days My god (on August 16th, 2014), pasted from the next day Monday to Saturday one, in selecting one day period of the day from 11 a.m. to 1 p.m for most containing of yang-energy, i.e. at 11 points at noon arrive At 1 point in afternoon；Do full dog days totally 9 times；Medicine cake is placed directly within acupuncture point (6), above puts hygenic towelette, places battery lead plate, Ion introducing apparatus is connected, is imported 20 minutes.Treatment group five is used as the application prepared by the Chinese medicine composition of embodiment 1, from three Lie prostrate and start first day (on July 18th, 2014) to last day (on August 16th, 2014), pasted from the next day Monday to Saturday one, selected Select the period of the day from 11 a.m. to 1 p.m that yang-energy is most contained in one day, i.e. at 11 points at noon at 1 point in afternoon；Do full dog days totally 9 times；Medicine cake is placed directly within On acupuncture point (6), 40 minutes.All treatment groups amount to 3 months from dog days' daystart MK, wherein >=6 Year infant 5mg, Qn, orally；5 years old infant 4mg, Qn, orally.

2. curative effect of disease compares

Curative effect of disease comparative result is shown in Table 9, and as can be seen from Table 9, embodiment 1 is always effective for the childhood asthma paracmasis Rate highest, has significant difference compared with treatment group, and effect becomes apparent from.

9 six groups of curative effect of disease comparative examples (%) of table

Group	n	It is effective	Effectively	It is invalid	Total effective rate (%)
						Embodiment 1	31	3	27	1	96.8
Treatment group one	30	2	23	5	83.3*
						Treatment group two	30	2	23	5	83.3*
Treatment group three	30	1	22	7	76.7*
						Treatment group four	30	2	22	6	80.0*
Treatment group five	30	2	21	7	76.7*

Note：The * P compared with the total effective rate of embodiment 1<0.05.

Described above is only the preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art Member, on the premise of the inventive method is not departed from, can also make some improvement and supplement, and these are improved and supplement also should be regarded as Protection scope of the present invention.

Claims (8)

1. a kind of Chinese medicine composition for treating the childhood asthma paracmasis, it is characterised in that it is by the bulk drug of following parts by weight It is made：6 parts of semen brassicae, 6 parts of corydalis tuber, 3 parts of the root of Dahurain angelica, 3 parts of the root of gansui, 3 parts of asarum, ginger 2-10 parts, cloves 2-10 parts, Chinese cassia tree 2- 10 parts.

2. application of the Chinese medicine composition in the medicine for preparing the treatment childhood asthma paracmasis described in claim 1.

3. application according to claim 2, it is characterised in that the medicine is used to reduce childhood asthma paracmasis patient's blood Clear EOS is horizontal, reduces inflammatory cell infiltration in air flue, mitigates chronic inflammation in bronchus.

4. application according to claim 2, it is characterised in that the medicine is used to reduce childhood asthma paracmasis Patients with Lung Functional parameter, air flue internal resistance is reduced, improve pulmonary ventilation function.

5. application according to claim 4, it is characterised in that the lung function index is PEF values.

6. application according to claim 2, it is characterised in that the formulation of described medicine is application.

7. application according to claim 6, it is characterised in that the described noon in dog days that is applied to is treated by electro-ionic osmosis Method is in patient's bilateral Dingchuan, feishu, region below the heart Acupoint Application in Treating.

8. the preparation method of the application described in claim any one of 6-7, it is characterised in that comprise the following steps：

A) medicine is weighed by weight, and mustard seed, corydalis tuber, the root of Dahurain angelica, the root of gansui, asarum are ground into medicinal powder；

B) by ginger crush, the medicinal powder in step a is modulated into pasty state with ginger juice and does patent medicine cake；

C) cloves, Chinese cassia tree are ground into medicinal powder, are spread on medicine cake and skin contact；Described cloves, Chinese cassia tree mass ratio are 1:1.