CN105998297A - Traditional Chinese medicine composition with effects of moistening intestines and relaxing bowels and preparation method thereof - Google Patents
Traditional Chinese medicine composition with effects of moistening intestines and relaxing bowels and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/13—Coniferophyta (gymnosperms)
- A61K36/15—Pinaceae (Pine family), e.g. pine or cedar
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/62—Nymphaeaceae (Water-lily family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
- A61K36/815—Lycium (desert-thorn)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8967—Lilium, e.g. tiger lily or Easter lily
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9068—Zingiber, e.g. garden ginger
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2068—Compounds of unknown constitution, e.g. material from plants or animals
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Abstract
The invention discloses a traditional Chinese medicine composition with effects of moistening intestines and relaxing bowels and a preparation method thereof. The traditional Chinese medicine composition comprises 6-12 parts of bitter apricot kernels, 6-12 parts of peach seeds, 3-8 parts of hemp seeds, 3-8 parts of pine nut kernels, 3-8 parts of dwarf flowering cherry seeds and 2-6 parts of orange peel and further comprises 4-7 parts of lotus seeds, 3-6 parts of lily, 3-6 parts of wolfberry and 2-5 parts of ginger. The traditional Chinese medicine composition has effects of moistening intestines and relaxing bowels, can be easily absorbed, has high bioavailability, can be processed to form granules, capsules, an oral liquid and pills, has substantial and precise curative effects and can be promoted and used.
Description
Technical field
The invention belongs to technical field of Chinese medicines, be specifically related to Chinese medicine composition of a kind of loosening bowel to relieve constipation and preparation method thereof.
Background technology
Constipation refers to that constipation is obstructed, defecation cycle stretch-out, or is intended to defecate and the most smooth involved and abstruse a kind of clinical symptoms.Long-term
Constipation can bring huge misery to patient, and the mental burden of making patients increases anxiety and tense emotion, and to human internal environment,
Hormonal system all has a certain impact, and is with the passing of time likely to induction or increases the weight of other diseases, affecting the quality of life of patient.
The traditional Chinese medical science is thought, constipation is many by heat accumulating in the large intestine, or the stagnation of QI, or cold coagulation, or yang blood and qi virtual loss, causes large intestine conduction function and loses
Often form.And old weakness constipation is many by Kidney-Yin loss, warm having no right, YIN pathogen condenses, or yin deficiency blood is dry, and big intestinal juice is withered, nothing
Lixing boat, belongs to deficiency syndrome more.
At present, in the traditional Chinese medical science, old weakness constipation is generally divided into (1) qi-deficiency type: disease sees that stool is the most stiff, discharges difficulty, empty
Seat is exerted and is earned, and sweating is breathed hard, the most weak, pallor Mental fatigue, and tongue the lung-pulse is weak；(2) blood-deficiency type: disease sees dry stool, has a dizzy spell,
Lusterless complexion, shortness of breath and palpitation, lip and nail color is light, and tongue the lung-pulse is weak；(3) YIN-deficiency type: disease is seen just such as sheep dung, emaciated physique, dizziness
Tinnitus, vexed sleeps less, hectic fever night sweat, soreness of the waist and knees, red tongue thready pulse；(4) deficiency of yang type: disease sees that stool discharges difficulty, urine
Clear long, pale white complexion, extremity are the warmest, cold type of pain in abdomen, pale tongue with white fur, deep-thready pulse.
Infantile constipation is generally divided into: (1) accumulated heat constipation: food variety is various now, and pediatric diet is improper, and surfeit is pungent little by zero
Food, fragrant dry puffed food or food are excessively fine, cause dryness-heat stagnating in the interior, and the conduction of intestinal internal organs is not normal, thus causes constipation；Disease is seen
Be hard and dry, hard, difficult defecation, abdominal distention suffers from abdominal pain, anorexia, the tired anxious halitosis of companion, feverish sensation in the palms and soles, and lip extra dry red wine is little
Just yellow few；Control suitable heat clearing away food stagnation removing.(2) weak constipation: many because of congenital insufficiency of the spleen, large intestine transmits unable or consumes impairment of body fluid liquid after being ill, greatly
Constipation tie, unable sending and cause；Disease sees frequent constipation, under difficulty in defecation or first dry rear dilute, shallow complexion, and abdominal distention vows gas,
Fatigue and weakness, pale tongue, tongue fur is white, moderate pulse；Due to difficult defecation, part children's can occur inappetence, sleep disorder,
Or owing to exerting oneself the most too time just, cause anal fissure or hemorrhoid, therefore control and preferably nourish loosening bowel to relieve constipation.
The old weakness constipation of chinese herbal compound treatment and infantile constipation method are various, dialectical treat, and treating both the principal and the secondary aspects of a disease at the same time is evident in efficacy.
Wuren pills (tcm prescription name), is recorded in " Young man Tibetan side " at first, has another name called taste intestinal wuren pills, is that " seminal fluid is withered in treatment according to load
Exhaust, large intestine secret puckery, conduct difficult " effect prescription.Former side is by Semen Persicae, Semen Armeniacae Amarum, Semen pini koraiensis, Semen Platycladi, Semen Pruni and old
Break flour, making pellets by mixing medical powder with honey, as Semen Firmianae is big.Often taking 30～50 balls, warm water takes.After be reproduced in again Effective Formulas Tested by Physicians for Generations,
Cure mainly intestine-dryness due to consumption of fluid card；Being hard and dry, involved and abstruse difficulty goes out, and old or blood deficiency and constipation in puerperal.Ancient prescription wuren pills collection is rich in oils and fats
Kernel in a side, the Pericarpium Citri Reticulatae of compatibility regulating qi-flowing for activating stagnancy, relaxing the bowels with lubricant drugs is harmonious with circulation of qi promoting, the main effect moisturizing laxation, but it is for old age
The symptoms such as people is weak, vexed, insomnia easily recur after not having good opsonic action, and drug withdrawal.Meanwhile, ancient prescription wuren pills with
Five Renhe Pericarpium Citri Reticulatae pulverizing pills, on the one hand directly taking former medicine is unfavorable for absorption of human body, and bioavailability is low；On the other hand, its
Type of preparation is single, and child or dysphagia person are not appropriate for taking pill, and affect patient takes wish.It addition, in mixed nuts
Rich in the unsaturated fatty acid such as linoleic acid, linolenic acid, unsaturated fatty acid has multiple unsaturated double-bond, so being oxidized easily,
Occurring spoiled by rancid oil or fat, the shelf-life causing wuren pills is short, is unfavorable for popularization and application.
To sum up, it is necessary to improve on the basis of ancient prescription wuren pills and optimize, to overcome its conditioning effect not good enough, biological profit
The deficiencies such as expenditure is low, easily recurs, oxidizable, unstable, provide a kind of intestine moistening to lead to for old weakness constipation patient and infantile constipation
Just, Chinese medicine composition evident in efficacy.
Summary of the invention
In order to solve problems of the prior art, (conditioning effect of ancient prescription wuren pills is not good enough, and bioavailability is low, and drug effect is owed
Good, oxidizable, unstable etc.), the invention provides the Chinese medicine composition of a kind of loosening bowel to relieve constipation, Chinese medicine composition of the present invention is easy
Absorbing, bioavailability is good, not only has effect of loosening bowel to relieve constipation, moreover it is possible to improvement is had a sleepless night, vexed gas is hot-tempered, and stable system,
Long shelf-life.
To achieve these goals, technical scheme is as follows:
The Chinese medicine composition of a kind of loosening bowel to relieve constipation, it is characterised in that include the raw material of preparing of following weight portion: Semen Armeniacae Amarum 6～12
Part, Semen Persicae 6～12 parts, Fructus Cannabis 3～8 parts, Semen pini koraiensis 3～8 parts, Semen Pruni 3～8 parts and Pericarpium Citri tangerinae 2～6 parts.
Preferably, the Chinese medicine composition of described loosening bowel to relieve constipation includes the raw material of preparing of following weight portion: Semen Armeniacae Amarum 8 parts, Semen Persicae
7 parts, Fructus Cannabis 6 parts, Semen pini koraiensis 6 parts, Semen Pruni 6 parts and Pericarpium Citri tangerinae 4 parts.
Further, described Chinese medicine composition also includes Semen Nelumbinis 4～7 parts, Bulbus Lilii 3～6 parts, Fructus Lycii 3～6 parts and Rhizoma Zingiberis Recens 2～5
Part.
Further, described Chinese medicine composition also includes 6 parts of Semen Nelumbinis, Bulbus Lilii 5 parts, Fructus Lycii 5 parts and 3 parts of Rhizoma Zingiberis Recens.
Further, described Chinese medicine composition is granule, capsule, oral liquid and pill.
Accordingly, present invention also offers the preparation method of the Chinese medicine composition of above-mentioned loosening bowel to relieve constipation, specifically include following steps:
S1, take the Semen Armeniacae Amarum of formula ratio, Semen Persicae, Fructus Cannabis, Semen pini koraiensis and Semen Pruni mixing, pulverize, cross 10 mesh sieves, add
Enter the water of 4～6 times of medical material amounts, soak 1.5～2h, filter, be subsequently added into the ethanol of 6～9 times of medical material amounts, in ultrasonic frequency
Being 30～40kHz, power is 200～300W, and Extracting temperature is to extract 1～2 time at 40～50 DEG C, each 30～40min, mistake
Filter, merging filtrate, filter vacuum is evaporated to the 1/4～1/3 of original volume, prepares concentrated solution A；
S2, take the Pericarpium Citri tangerinae of formula ratio, pulverize, cross 10 mesh sieves, add the water of 3～6 times of medical material amounts, reflux, extract, 1～2h, mistake
Filter, filter vacuum is evaporated to the 1/4～1/3 of original volume, prepares Pericarpium Citri tangerinae concentrated solution；
S3, take the Semen Nelumbinis of formula ratio, Bulbus Lilii and Fructus Lycii mixing, pulverized 10 mesh sieves, and added the water of 4～7 times of medical material amounts, and returned
Stream extracts 2～3h, filters, and filter vacuum is evaporated to the 1/4～1/3 of original volume, prepares concentrated solution B；
S4, take the Rhizoma Zingiberis Recens of formula ratio, section, add the ethanol of 2～4 times of medical material amounts, reflux, extract, 1～2h, filter, filtrate
Vacuum-concentrcted, to the 1/4～1/3 of original volume, prepares Rhizoma Zingiberis Recens concentrated solution；
S5, by described concentrated solution A, Pericarpium Citri tangerinae concentrated solution, concentrated solution B and Rhizoma Zingiberis Recens concentrated solution mix, mixed liquor is at vacuum decompression
Being concentrated into relative density at 60 DEG C is the extractum of 1.10～1.20, drying under reduced pressure, pulverizes, and prepares the Chinese medicine composition of loosening bowel to relieve constipation.
Further, in described step S1, the concentration of volume percent of ethanol is 90～95%.
Further, in described step S4, the concentration of volume percent of ethanol is 60～70%.
In the inventive solutions, Semen Armeniacae Amarum is the dry mature kernal of rosaceous plant Fructus Pruni, wild apricot, Prunus armeniaca L.var.ansu Maxim., prunus mandshuricaKoehne,
Detoxification, peeling；Semen Persicae is the dry mature seed of rosaceous plant Fructus Persicae or Prunus davidiana.Fructus Cannabis is moraceae plants Fructus Cannabis
The dry mature kernal of (Cannabis sativa L.)；Semen pini koraiensis is the Pinus armandi Franch-P. Komavovii Lavl. in Pinaceae pine genus plant, Pinus koraiensis, Pinus massoniana Lamb
Dry mature kernal；Semen Pruni is the dry mature seed of strongly fragrant Lee of rosaceous plant, Prunus humilis, flowering plum and long stalk almond etc..
Pericarpium Citri tangerinae is rutaceae orange (Citrus reticulataBlanco) and the dry mature skin of variety thereof.Semen Nelumbinis are Flos nymphaeae (Nymphaea teragona Georgi)
The dry mature seed of section plant lotus (Nelumbo nucifera Gaertn.)；Bulbus Lilii be liliaceous plant Bulbus Lilii, Lilium tenuifolium,
Lilium longiflorum and belong to the dry scale leaf of various plants bulb together；Fructus Lycii is the dry mature fruit of plant of Solanaceae lycium barbarum；Raw
Rhizoma Zingiberis Recens is the fresh rhizome of Zingiberaceae herbaceos perennial Rhizoma Zingiberis Recens (Zingiber officinale Roscoe).
It is monarch drug with the Semen Armeniacae Amarum of matter profit greasiness, to grow dryness of the intestine, and fall lung qi, and the duty of profit large intestine conduction；With Semen Persicae as ministerial drug,
Take it and moisturize laxation, to help the power of Semen Armeniacae Amarum；The many lubrications of Fructus Cannabis, lung moistening is controlled dry, with controlling constipation due to insufficiency；Semen Pruni matter lubricant nature drops,
Lubrication intestinal, specially controls the intestines and stomach scorching, constipation；Semen pini koraiensis moistening five ZANG-organs, controls constipation due to insufficiency, is adjuvant drug altogether；Multiple regulate the flow of vital energy row with Pericarpium Citri tangerinae
Stagnant, make gas row then large intestine be able to transporting.
Compounding prescription with Semen Nelumbinis, Bulbus Lilii, Fructus Lycii and Rhizoma Zingiberis Recens further, Semen Nelumbinis clear away heart-fire relieving restlessness, tranquilizing by nourishing the heart, Bulbus Lilii benefiting qi and nourishing yin,
Clear waste heat, Fructus Lycii nourishing the liver and kidney, replenishing vital essence to improve eyesight, be adjuvant drug altogether；Rhizoma Zingiberis Recens warming spleen and stomach for dispelling cold, appetite promoting and the spleen strengthening, for making medicine, all medicines close
With, play altogether loosening bowel to relieve constipation, feel at ease to allay excitement, the effect of vital base and primordial QI consolidating.
It addition, inventor it has been unexpectedly discovered that the addition of Semen Nelumbinis, Bulbus Lilii, Fructus Lycii and Rhizoma Zingiberis Recens, not only effect of loosening bowel to relieve constipation is had
Assosting effect, and can nurse one's health vexed, gas is hot-tempered, the situation such as weak, improves sleep quality, be also effectively increased Semen Armeniacae Amarum,
The stability of Semen Persicae, Fructus Cannabis, Semen pini koraiensis and Semen Pruni extract so that present composition stable system, long shelf-life.
By the Chinese medicine composition of the loosening bowel to relieve constipation that preparation method of the present invention prepares, compared with ancient prescription wuren pills, its curative effect is the most aobvious
Writing, and be difficult to recurrence, on the one hand reflecting preparation method of the present invention can effectively extract the active component of crude drug, reaches treatment old
The purpose of year weakness constipation, on the other hand embodies Chinese medicine composition of the present invention and is easier to be absorbed by the body, and bioavailability is high；
Meanwhile, Chinese medicine composition of the present invention also can be made into the various dosage forms such as granule, capsule, oral liquid and pill, meets people
Demand.
Therefore, compared with prior art, present invention have an advantage that
(1) Chinese medicine composition of loosening bowel to relieve constipation of the present invention easily absorbs, and bioavailability is high, not only has effect of loosening bowel to relieve constipation,
Can also nurse one's health vexed, gas is hot-tempered, the situation such as weak, improves sleep quality, to old weakness constipation and the therapeutic effect of infantile constipation
Significantly, definitely, and stable system, long shelf-life, also can be made into the various dosage forms such as granule, oral liquid and pill, have
Good application prospect.
(2) condition of the Chinese medicine composition preparation method of loosening bowel to relieve constipation of the present invention is controlled, process stabilizing, can industrialized production,
Be conducive to popularization and application.
Detailed description of the invention
Further describing the present invention below by way of specific embodiment, the present invention is not limited only to following example.Model in the present invention
Enclose interior or without departing from present disclosure, spirit and scope, change that the present invention is carried out, combine or replace, for
It is apparent from for those skilled in the art, and is included within the scope of the present invention.
Embodiment 1, the Chinese medicine composition of loosening bowel to relieve constipation of the present invention and preparation thereof
Formula: Semen Armeniacae Amarum 6kg, Semen Persicae 6kg, Fructus Cannabis 3kg, Semen pini koraiensis 3kg, Semen Pruni 3kg and Pericarpium Citri tangerinae 2kg.
Preparation method: S1, take the Semen Armeniacae Amarum of formula ratio, Semen Persicae, Fructus Cannabis, Semen pini koraiensis and Semen Pruni mixing, pulverize, mistake
10 mesh sieves, add 84kg water, soak 1.5h, filter, are subsequently added into the ethanol that 126kg concentration of volume percent is 90%,
Being 30kHz in ultrasonic frequency, power is 200W, and Extracting temperature is to extract 1 time at 40 DEG C, and each 40min filters,
Merging filtrate, filter vacuum is evaporated to the 1/4 of original volume, prepares concentrated solution A；
S2, take the Pericarpium Citri tangerinae of formula ratio, pulverize, cross 10 mesh sieves, add 6kg water, reflux, extract, 1h, filter, filter vacuum
It is evaporated to the 1/4 of original volume, prepares Pericarpium Citri tangerinae concentrated solution；
S3, by described concentrated solution A, Pericarpium Citri tangerinae concentrated solution mixing, mixed liquor relative density at vacuum-concentrcted to 60 DEG C is
The extractum of 1.10, drying under reduced pressure, pulverize 80 mesh sieves, prepare the Chinese medicine composition of loosening bowel to relieve constipation.
Separately taking Mel and carry out refined honey, the refined honey obtained mixes according to weight ratio 1:1 with above-mentioned Chinese medicine composition medicated powder, pill block,
Rub ball bar, pill grain, every ball weight 0.2g with the hands, i.e. prepare the honeyed pill of the Chinese medicine composition of loosening bowel to relieve constipation of the present invention.
Embodiment 2, the Chinese medicine composition of loosening bowel to relieve constipation of the present invention and preparation thereof
Formula: Semen Armeniacae Amarum 12kg, Semen Persicae 12kg, Fructus Cannabis 8kg, Semen pini koraiensis 8kg, Semen Pruni 8kg and Pericarpium Citri tangerinae 6kg.
Preparation method: S1, take the Semen Armeniacae Amarum of formula ratio, Semen Persicae, Fructus Cannabis, Semen pini koraiensis and Semen Pruni mixing, pulverize, mistake
10 mesh sieves, add 288kg water, soak 2h, filter, are subsequently added into the ethanol that 432kg concentration of volume percent is 95%,
Being 40kHz in ultrasonic frequency, power is 300W, and Extracting temperature is to extract 2 times at 50 DEG C, and each 30min filters,
Merging filtrate, filter vacuum is evaporated to the 1/3 of original volume, prepares concentrated solution A；
S2, taking the Pericarpium Citri tangerinae of formula ratio, pulverize, cross 10 mesh sieves, add 36kg water, reflux, extract, 2h, filter, filtrate is true
Sky is evaporated to the 1/3 of original volume, prepares Pericarpium Citri tangerinae concentrated solution；
S3, by described concentrated solution A, Pericarpium Citri tangerinae concentrated solution mixing, mixed liquor relative density at vacuum-concentrcted to 60 DEG C is
The extractum of 1.20, drying under reduced pressure, pulverize 80 mesh sieves, prepare the Chinese medicine composition of loosening bowel to relieve constipation.
Separately taking Mel and carry out refined honey, the refined honey obtained mixes according to weight ratio 1:1 with above-mentioned Chinese medicine composition medicated powder, pill block,
Rub ball bar, pill grain, every ball weight 0.2g with the hands, i.e. prepare the honeyed pill of the Chinese medicine composition of loosening bowel to relieve constipation of the present invention.
Embodiment 3, the Chinese medicine composition of loosening bowel to relieve constipation of the present invention and preparation thereof
Formula: Semen Armeniacae Amarum 8kg, Semen Persicae 7kg, Fructus Cannabis 6kg, Semen pini koraiensis 6kg, Semen Pruni 6kg and Pericarpium Citri tangerinae 4kg.
Preparation method: S1, take the Semen Armeniacae Amarum of formula ratio, Semen Persicae, Fructus Cannabis, Semen pini koraiensis and Semen Pruni mixing, pulverize, mistake
10 mesh sieves, add 165kg water, soak 2h, filter, are subsequently added into the ethanol that 231kg concentration of volume percent is 95%,
Being 35kHz in ultrasonic frequency, power is 200W, and Extracting temperature is to extract 2 times at 45 DEG C, and each 30min filters,
Merging filtrate, filter vacuum is evaporated to the 1/3 of original volume, prepares concentrated solution A；
S2, taking the Pericarpium Citri tangerinae of formula ratio, pulverize, cross 10 mesh sieves, add 20kg water, reflux, extract, 1h, filter, filtrate is true
Sky is evaporated to the 1/3 of original volume, prepares Pericarpium Citri tangerinae concentrated solution；
S3, by described concentrated solution A, Pericarpium Citri tangerinae concentrated solution mixing, mixed liquor relative density at vacuum-concentrcted to 60 DEG C is
The extractum of 1.20, drying under reduced pressure, pulverize 80 mesh sieves, prepare the Chinese medicine composition of loosening bowel to relieve constipation.
Separately taking Mel and carry out refined honey, the refined honey obtained mixes according to weight ratio 1:1 with above-mentioned Chinese medicine composition medicated powder, pill block,
Rub ball bar, pill grain, every ball weight 0.2g with the hands, i.e. prepare the honeyed pill of the Chinese medicine composition of loosening bowel to relieve constipation of the present invention.
Embodiment 4, the Chinese medicine composition of loosening bowel to relieve constipation of the present invention and preparation thereof
Formula: Semen Armeniacae Amarum 8kg, Semen Persicae 7kg, Fructus Cannabis 6kg, Semen pini koraiensis 6kg, Semen Pruni 6kg and Pericarpium Citri tangerinae 4kg.
Preparation method, with embodiment 3, prepares the Chinese medicine composition of loosening bowel to relieve constipation.
According to common process, taking above-mentioned Chinese medicine composition medicated powder, the volume fraction adding 3 times of medicated powder weights is 65% ethanol, fills
Dividing stirring, left at room temperature 24h, take supernatant, decompression recycling ethanol, until supernatant is without alcohol taste, obtains medicinal liquid；Toward described
The water adding 6 times of medicinal liquids weight in medicinal liquid is diluted, and filters Chinese medicine composition oral i.e. obtaining loosening bowel to relieve constipation of the present invention after standing
Liquid.
Embodiment 5, the Chinese medicine composition of loosening bowel to relieve constipation of the present invention and preparation thereof
Formula: Semen Armeniacae Amarum 8kg, Semen Persicae 7kg, Fructus Cannabis 6kg, Semen pini koraiensis 6kg, Semen Pruni 6kg and Pericarpium Citri tangerinae 4kg.
Preparation method, with embodiment 3, prepares the Chinese medicine composition of loosening bowel to relieve constipation.
According to common process, above-mentioned Chinese medicine composition medicated powder is mixed with adjuvant, dry granulation, granulate, i.e. prepare present invention profit
The granule of the Chinese medicine composition of intestinal relieving constipation.
Embodiment 6, the Chinese medicine composition of loosening bowel to relieve constipation of the present invention and preparation thereof
Formula: Semen Armeniacae Amarum 6kg, Semen Persicae 6kg, Fructus Cannabis 3kg, Semen pini koraiensis 3kg, Semen Pruni 3kg and Pericarpium Citri tangerinae 2kg.
Preparation method, with embodiment 2, prepares the Chinese medicine composition of loosening bowel to relieve constipation.
According to common process, above-mentioned Chinese medicine composition medicated powder is mixed with adjuvant, dry granulation, granulate, i.e. prepare present invention profit
The granule of the Chinese medicine composition of intestinal relieving constipation.
Embodiment 7, the Chinese medicine composition of loosening bowel to relieve constipation of the present invention and preparation thereof
Formula: Semen Armeniacae Amarum 12kg, Semen Persicae 12kg, Fructus Cannabis 8kg, Semen pini koraiensis 8kg, Semen Pruni 8kg and Pericarpium Citri tangerinae 6kg.
Preparation method, with embodiment 1, prepares the Chinese medicine composition of loosening bowel to relieve constipation.
According to common process, above-mentioned Chinese medicine composition medicated powder is mixed with adjuvant, dry granulation, granulate, i.e. prepare present invention profit
The granule of the Chinese medicine composition of intestinal relieving constipation.
Embodiment 8, the Chinese medicine composition of loosening bowel to relieve constipation of the present invention and preparation thereof
Formula: Semen Armeniacae Amarum 8kg, Semen Persicae 7kg, Fructus Cannabis 6kg, Semen pini koraiensis 6kg, Semen Pruni 6kg, Pericarpium Citri tangerinae 4kg, Semen Nelumbinis
4kg, Bulbus Lilii 3kg, Fructus Lycii 3kg and Rhizoma Zingiberis Recens 2kg.
Preparation method: S1, take the Semen Armeniacae Amarum of formula ratio, Semen Persicae, Fructus Cannabis, Semen pini koraiensis and Semen Pruni mixing, pulverize, mistake
10 mesh sieves, add 132kg water, soak 2h, filter, are subsequently added into the ethanol that 198kg concentration of volume percent is 90%,
Being 30kHz in ultrasonic frequency, power is 200W, and Extracting temperature is to extract 1 time at 40 DEG C, and each 40min filters,
Merging filtrate, filter vacuum is evaporated to the 1/4 of original volume, prepares concentrated solution A；
S2, taking the Pericarpium Citri tangerinae of formula ratio, pulverize, cross 10 mesh sieves, add 12kg water, reflux, extract, 1h, filter, filtrate is true
Sky is evaporated to the 1/4 of original volume, prepares Pericarpium Citri tangerinae concentrated solution；
S3, take the Semen Nelumbinis of formula ratio, Bulbus Lilii and Fructus Lycii mixing, pulverized 10 mesh sieves, add 40kg water, reflux, extract, 2h,
Filtering, filter vacuum is evaporated to the 1/4 of original volume, prepares concentrated solution B；
S4, take the Rhizoma Zingiberis Recens of formula ratio, section, adding 4kg concentration of volume percent is the ethanol of 60%, reflux, extract, 1h,
Filtering, filter vacuum is evaporated to the 1/3 of original volume, prepares Rhizoma Zingiberis Recens concentrated solution；
S5, by described concentrated solution A, Pericarpium Citri tangerinae concentrated solution, concentrated solution B and Rhizoma Zingiberis Recens concentrated solution mix, mixed liquor is at vacuum decompression
Being concentrated into relative density at 60 DEG C is the extractum of 1.10, and drying under reduced pressure pulverized 80 mesh sieves, prepares the Chinese drug-treated group of loosening bowel to relieve constipation
Compound.
Separately taking Mel and carry out refined honey, the refined honey obtained mixes according to weight ratio 1:1 with above-mentioned Chinese medicine composition medicated powder, pill block,
Rub ball bar, pill grain, every ball weight 0.2g with the hands, i.e. prepare the honeyed pill of the Chinese medicine composition of loosening bowel to relieve constipation of the present invention.
Embodiment 9, the Chinese medicine composition of loosening bowel to relieve constipation of the present invention and preparation thereof
Formula: Semen Armeniacae Amarum 8kg, Semen Persicae 7kg, Fructus Cannabis 6kg, Semen pini koraiensis 6kg, Semen Pruni 6kg, Pericarpium Citri tangerinae 4kg, Semen Nelumbinis
7kg, Bulbus Lilii 6kg, Fructus Lycii 6kg and Rhizoma Zingiberis Recens 5kg.
Preparation method: S1, take the Semen Armeniacae Amarum of formula ratio, Semen Persicae, Fructus Cannabis, Semen pini koraiensis and Semen Pruni mixing, pulverize, mistake
10 mesh sieves, add 198kg water, soak 2h, filter, are subsequently added into the ethanol that 297kg concentration of volume percent is 95%,
Being 40kHz in ultrasonic frequency, power is 300W, and Extracting temperature is to extract 2 times at 50 DEG C, and each 30min filters,
Merging filtrate, filter vacuum is evaporated to the 1/3 of original volume, prepares concentrated solution A；
S2, taking the Pericarpium Citri tangerinae of formula ratio, pulverize, cross 10 mesh sieves, add 24kg water, reflux, extract, 2h, filter, filtrate is true
Sky is evaporated to the 1/4 of original volume, prepares Pericarpium Citri tangerinae concentrated solution；
S3, take the Semen Nelumbinis of formula ratio, Bulbus Lilii and Fructus Lycii mixing, pulverized 10 mesh sieves, add 133kg water, reflux, extract, 3h,
Filtering, filter vacuum is evaporated to the 1/3 of original volume, prepares concentrated solution B；
S4, take the Rhizoma Zingiberis Recens of formula ratio, section, adding 20kg concentration of volume percent is the ethanol of 70%, reflux, extract, 2h,
Filtering, filter vacuum is evaporated to the 1/4 of original volume, prepares Rhizoma Zingiberis Recens concentrated solution；
S5, by described concentrated solution A, Pericarpium Citri tangerinae concentrated solution, concentrated solution B and Rhizoma Zingiberis Recens concentrated solution mix, mixed liquor is at vacuum decompression
Being concentrated into relative density at 60 DEG C is the extractum of 1.20, and drying under reduced pressure pulverized 80 mesh sieves, prepares the Chinese drug-treated group of loosening bowel to relieve constipation
Compound.
Separately taking Mel and carry out refined honey, the refined honey obtained mixes according to weight ratio 1:1 with above-mentioned Chinese medicine composition medicated powder, pill block,
Rub ball bar, pill grain, every ball weight 0.2g with the hands, i.e. prepare the honeyed pill of the Chinese medicine composition of loosening bowel to relieve constipation of the present invention.
Embodiment 10, the Chinese medicine composition of loosening bowel to relieve constipation of the present invention and preparation thereof
Formula: Semen Armeniacae Amarum 8kg, Semen Persicae 7kg, Fructus Cannabis 6kg, Semen pini koraiensis 6kg, Semen Pruni 6kg, Pericarpium Citri tangerinae 4kg, Semen Nelumbinis
6kg, Bulbus Lilii 5kg, Fructus Lycii 5kg and Rhizoma Zingiberis Recens 3kg.
Preparation method: S1, take the Semen Armeniacae Amarum of formula ratio, Semen Persicae, Fructus Cannabis, Semen pini koraiensis and Semen Pruni mixing, pulverize, mistake
10 mesh sieves, add 165kg water, soak 2h, filter, are subsequently added into the ethanol that 231kg concentration of volume percent is 95%,
Being 35kHz in ultrasonic frequency, power is 200W, and Extracting temperature is to extract 2 times at 45 DEG C, and each 30min filters,
Merging filtrate, filter vacuum is evaporated to the 1/3 of original volume, prepares concentrated solution A；
S2, taking the Pericarpium Citri tangerinae of formula ratio, pulverize, cross 10 mesh sieves, add 20kg water, reflux, extract, 1h, filter, filtrate is true
Sky is evaporated to the 1/3 of original volume, prepares Pericarpium Citri tangerinae concentrated solution；
S3, take the Semen Nelumbinis of formula ratio, Bulbus Lilii and Fructus Lycii mixing, pulverized 10 mesh sieves, add 96kg water, reflux, extract, 2h,
Filtering, filter vacuum is evaporated to the 1/3 of original volume, prepares concentrated solution B；
S4, take the Rhizoma Zingiberis Recens of formula ratio, section, adding 9kg concentration of volume percent is the ethanol of 65%, reflux, extract, 2h,
Filtering, filter vacuum is evaporated to the 1/3 of original volume, prepares Rhizoma Zingiberis Recens concentrated solution；
S5, by described concentrated solution A, Pericarpium Citri tangerinae concentrated solution, concentrated solution B and Rhizoma Zingiberis Recens concentrated solution mix, mixed liquor is at vacuum decompression
Being concentrated into relative density at 60 DEG C is the extractum of 1.20, and drying under reduced pressure pulverized 80 mesh sieves, prepares the Chinese drug-treated group of loosening bowel to relieve constipation
Compound.
Separately taking Mel and carry out refined honey, the refined honey obtained mixes according to weight ratio 1:1 with above-mentioned Chinese medicine composition medicated powder, pill block,
Rub ball bar, pill grain, every ball weight 0.2g with the hands, i.e. prepare the honeyed pill of the Chinese medicine composition of loosening bowel to relieve constipation of the present invention.
Embodiment 11, the Chinese medicine composition of loosening bowel to relieve constipation of the present invention and preparation thereof
Formula: Semen Armeniacae Amarum 8kg, Semen Persicae 7kg, Fructus Cannabis 6kg, Semen pini koraiensis 6kg, Semen Pruni 6kg, Pericarpium Citri tangerinae 4kg, Semen Nelumbinis
6kg, Bulbus Lilii 5kg, Fructus Lycii 5kg and Rhizoma Zingiberis Recens 3kg.
Preparation method, with embodiment 10, prepares the Chinese medicine composition of loosening bowel to relieve constipation.
According to common process, taking above-mentioned Chinese medicine composition medicated powder, the volume fraction adding 3 times of medicated powder weights is 65% ethanol, fills
Dividing stirring, left at room temperature 24h, take supernatant, decompression recycling ethanol, until supernatant is without alcohol taste, obtains medicinal liquid；Toward described
The water adding 6 times of medicinal liquids weight in medicinal liquid is diluted, and filters Chinese medicine composition oral i.e. obtaining loosening bowel to relieve constipation of the present invention after standing
Liquid.
Comparative example 1, ancient prescription wuren pills
Semen Persicae 30g, Semen Armeniacae Amarum 30g, Semen pini koraiensis 3g, Semen Platycladi 15g, Semen Pruni 3g and Pericarpium Citri tangerinae 120g, pulverized 80 mesh sieves,
Separately taking Mel and carry out refined honey, the refined honey obtained mixes according to weight ratio 1:1 with above-mentioned medicated powder, pill block, stranding ball bar, pill grain,
Every ball weight 0.2g, i.e. prepares this comparative example honeyed pill.
Comparative example 2
Formula: Semen Nelumbinis 6kg, Bulbus Lilii 5kg, Fructus Lycii 5kg and Rhizoma Zingiberis Recens 3kg.
Preparation method reference example 10, prepares this comparative example honeyed pill.
Comparative example 3
Formula: Semen Armeniacae Amarum 8kg, Semen Persicae 7kg, Fructus Cannabis 6kg, Semen pini koraiensis 6kg, Semen Pruni 6kg, Pericarpium Citri tangerinae 4kg, Semen Nelumbinis
6kg and Bulbus Lilii 5kg.
Preparation method reference example 10, prepares the honeyed pill of this comparative example.
Comparative example 4
Formula: Semen Armeniacae Amarum 8kg, Semen Persicae 7kg, Fructus Cannabis 6kg, Semen pini koraiensis 6kg, Semen Pruni 6kg, Pericarpium Citri tangerinae 4kg, Fructus Lycii
5kg and Rhizoma Zingiberis Recens 3kg.
Preparation method reference example 10, prepares the honeyed pill of this comparative example.
Comparative example 5
The formula of this comparative example is same as in Example 10.
And preparation method is compared with Example 10, differing only in of this comparative example: S4, take the Rhizoma Zingiberis Recens of formula ratio, section,
Adding 9kg water, reflux, extract, 2h, filter, filter vacuum is evaporated to the 1/3 of original volume, prepares Rhizoma Zingiberis Recens concentrated solution.
Test example one, the Chinese medicine composition therapeutic effect to chronic slow-transit constipation mouse model of loosening bowel to relieve constipation of the present invention
1. test objective
Experimental mice subcutaneous injection morphine induction sets up chronic slow-transit constipation mouse model, records stool in mice weight, utilizes and lives
Property the test of charcoal administration by gavage compare administration group and control group mice Colonic transit activity.
2. material
Specific-pathogen free SPF level ICR Mus 86, male and female half and half, body weight 22～26 grams；(Suzhou Feng Shi tests mouse metabolism cage
Animal company)；Hydrochloride for injection morphine (Shenyang No. 1 Pharmaceutical Factory, specification 10mg/ is propped up)；Normal saline；One anti-(sc-168, Santa
Cruz Biotechnology, Inc, 200mg/L)；Two anti-(goat anti-rabbit antibody, Zhong Shan biotechnology company).
3. test methods and procedures
The foundation of 3.1 chronic slow-transit constipation mouse models
ICR Mus 86, mice is inserted in 86 mouse metabolism cage, and SPF level environment is raised.After adaptability is fed 3 days, administration group
With model control group mouse subcutaneous injection morphine hydrochloride 2.5mg/ (kg d), Normal group injection normal saline.Every 3 days notes
Record mice stool grain number, stool dry weight and Mouse Weight, calculate average daily defecation weight (g) of mice.Daily arrange with mice
Just measure minimizing, and average daily feces volume has significant difference building as chronic slow-transit constipation mouse model compared with Normal group
Vertical successfully mark, stops drug administration by injection after modeling success.
The mensuration of 3.2 mice average daily defecation weight
Give with modeling success after 80 mices of (raise and rise for the 46th day), be randomly divided into embodiment 1～3,8～10 groups, comparative example
1,2, Normal group and model control group, often group 8.According to following Dosage Regimens Dosage:
Embodiment 1 group: the honeyed pill that Example 1 prepares, smashs to pieces, adds honeyed pill and weighs the distilled water of 4 times amount, stirs evenly, and gavage is given
Medicine, dosage is 6.0g/kg.
Embodiment 2,3,8,9,10 groups and comparative example 1 group Example 2,3,8,9,10 respectively and comparative example 1,2 prepare
Honeyed pill be administered, dosage regimen is with embodiment 1 group.Normal group and model control group give isopyknic distilled water.
It is administered once a day, every mice stool grain number of 1 day record, stool dry weight and Mouse Weight, calculates mice average daily
Defecation weight (g).Mice average daily feces volume minimizing compared with normal group, shows that chronic slow-transit constipation degree increases.
3.3 intestinal transfer functions measure
First grain melena efflux time is measured with activated carbon administration by gavage.Drug withdrawal all mice fasting of 1 week 24 hours, per os pours into
100mg/ml carbon suspensioning liquid 2ml.From activated carbon gavage is complete start time timing, record when gavage to first grain melena is discharged
Between.First grain melena efflux time is the longest shows that chronic slow-transit constipation degree is the biggest.
The statistical procedures of 3.4 test datas
Experimental data typing SPSS 20.0 statistical package, statistical method selects t inspection.
4. result
The impact on chronic slow-transit constipation mice of the table 1 each administration group
Compare with Normal group, ##p < 0.01；Compared with model control group, * p < 0.05, * * p < 0.01.
Seeing the above table 1, animal test results shows:
(1) compared with Normal group, the average daily feces volume of model control group mice, first grain melena efflux time are respectively provided with the most aobvious
Write sex differernce (p < 0.01), show that chronic slow-transit constipation mouse model is built successfully；
(2) compared with model control group mice, embodiment 1～3 groups of average daily feces volumes of mice, first grain melena efflux times have aobvious
Writing sex differernce (p < 0.05), embodiment 8～10 groups of average daily feces volumes of mice, first grain melena efflux times have pole significant difference
(p < 0.01), and comparative example 1 and 2 groups the most do not possess significant difference, this shows that Chinese medicine composition of the present invention has loosening bowel to relieve constipation
Effect, it is possible to be obviously improved mice feces volume, strengthen mouse intestinal propulsive force, alleviate the symptom of slow-remove type mice with constipation,
And more obvious than the effect of ancient prescription wuren pills, and embodiment 8～10 groups are better than embodiment 1～3 groups, wherein with embodiment 10 Chinese drug-treated group
The action effect of compound is optimal, for highly preferred embodiment of the present invention.
(3) during test, without dead mouse, also find no mice and occur that the bodily form is become thin, lost hair or feathers, activity minimizing, vomits
The undesirable condition such as tell.
Test example two, the Chinese medicine composition therapeutic effect to old weakness constipation of loosening bowel to relieve constipation of the present invention
1. clinical data
In 1.1 physical data 150 example volunteers, male 80 examples, female 70 example, age reckling 59 years old, the maximum 81 years old, averagely
68 years old, the course of disease was the shortest 2 months, the longest 6 years.Clinical treatment suffers from the organic diseases such as rectal cancer, rectal polyp, anal haemorrhoids
Sick and cause within constipation person excludes statistics.
1.2 diagnostic criterias are with reference to " disease of tcm Standardization of diagnosis and curative effect ".Organic disease is got rid of in training inspection, and defecation time is long,
3 days or more than 3 days 1 time, or feces is dried, scleroma, though or without the unable discharge of dryness accumulated in the stomach and intestine, for a long time without awareness of defecation.Patient is with few abdomen
Discomfort, poor appetite lack of appetite, emotion is unhappy, tired mind, and patient, with insomnia (course of disease is the shortest 2 months, the longest 5 years), lacks abdomen
Dull pain.Qi-deficiency type 30 example in 150 examples, blood-deficiency type 33 example, YIN-deficiency type 42, deficiency of yang type 45 example, each typing random packet.
2. Therapeutic Method
It is divided into 3 groups, takes the honeyed pill that embodiment 3, embodiment 10 and comparative example 1 prepare respectively, sooner or later respectively take 1 dose every day, 1 dose
30 balls.Within 10 days, it was 1 course for the treatment of, treats 3 courses for the treatment of.Advise patient's moderate exercise, polyphagia vegetable and fruit during taking medicine, drink more water, stop
Use other cathartics, adhere to timing every day stool.
3. Ureteral Calculus
3.1 criterions of therapeutical effect are with reference to " disease of tcm Standardization of diagnosis and curative effect ".(1) constipation: cure: defecation 1 time in 2 days, just
Matter turns profit, and defecation is unobstructed；Taking a turn for the better: defecation 1 time in 3 days, just matter turns profit, and defecation owes smooth；Invalid: after medication constipation symptom without
Any alleviation.(2) sleep: cure: nighttime sleep, more than 6 hours, is slept deep；Take a turn for the better: Nighttime sleep increases
More than 2 hours, Depth of sleep increased；Invalid: after medication, sleep state does not improve.
3.2 therapeutic effect (are shown in Table 2)
Table 2 therapeutic outcome
Seeing the above table 2, clinical test results shows:
(1) embodiment of the present invention 3 and embodiment 10 honeyed pill are concrete to old qi-deficiency type, blood-deficiency type, YIN-deficiency type and astriction of insufficiency of yang type
Significantly therapeutic effect, and more excellent compared with the therapeutic effect of ancient prescription wuren pills, wherein the average total effective rate of embodiment 3 honeyed pill is close
90%, and the average total effective rate of embodiment 8 honeyed pill is 100%, therapeutic effect is notable.
(2) embodiment of the present invention 10 honeyed pill can improve insomnia, extends the length of one's sleep, increases Depth of sleep, improves sleep quality,
Total effective rate reaches 92%.And embodiment 3 and comparative example 1 honeyed pill do not have the effect improving insomnia.
3.3 recurrence
After 3 courses for the treatment of terminate, each packet healing person's withdrawal, after 1 month, healing person is paid a return visit, investigate recurrence.
Take the healing person 22 of embodiment 3 honeyed pill, recidivist 8 after healing, relapse rate 36.4%；Take controlling of embodiment 10 honeyed pill
More person 31, recidivist 5 after healing, relapse rate 16.1%；Take the healing person 9 of comparative example 1 honeyed pill, recur after healing
Person 8, relapse rate 88.9%.Visible, taking the Chinese medicine composition of loosening bowel to relieve constipation of the present invention, to control recurrence rate after healing low, and curative effect is true
Cut.
Test example three, the study on the stability of Chinese medicine composition of loosening bowel to relieve constipation of the present invention
According to " Chinese Pharmacopoeia " (2015), the stability of the embodiment of the present invention 3,10 and comparative example 1,3～5 honeyed pill is carried out
Long term test, under the conditions of commercially available back, in 25 DEG C ± 2 DEG C, place under conditions of relative humidity 60% ± 10%, respectively at 3,
6, sampling in 9,12,18,24 months, checks character, discriminating, microbial limit and degree of becoming sour.Result see table 3.
Character description: rufous honeyed pill, feeble QI, mildly bitter flavor.
Differentiate: use thin layer chromatography to carry out qualitative identification.
Limit test of microbe: the most various pills all must not detect miscellaneous bacteria, the funguses such as demodicid mite alive, demodicid mite ovum and escherichia coli；
Detect by microbial limit test.
Become sour degree: take a certain amount of sample, add after suitable quantity of water dissolves, extract 3 times with petroleum ether (30～60 DEG C) 20ml,
Combining extraction liquid, water-bath volatilizes rear gained oil and is placed in 50ml conical flask, adds hydrochloric acid 5ml, mixing, adds marble 3～4 immediately
Grain, stoppers the cork installing phloroglucinol reagent paper, places 20min about 25 DEG C of water-baths, and the reagent paper person that do not reddens be feminine gender,
" " represents reaction negative, "+" represent reacting positive.(principle: unsaturated fatty acid is oxidized and becomes sour, and produces
Oxide, peroxide extremely unstable, may proceed to oxidation, produce aldehydes, ketone and organic acid etc., and aldehydes, ketone are thorns
Swash the main source of property abnormal smells from the patient, namely rancid flavor.)
Table 3
Seeing the above table 3, long-term test results shows:
(1) embodiment 1 honeyed pill deposit 12 months there occurs rotten, comparative example 1 ancient prescription wuren pills deposit 9 months there occurs rotten,
And the stability of embodiment 10 honeyed pill is high, long shelf-life, after depositing 2 years, appearance character, diagnostic characteristics, microbial limit etc. are equal
Meet pharmacopoeial requirements, and do not have to become sour.
(2) compared with Example 10, comparative example 3 and comparative example 4 change formula, comparative example 5 change preparation method, its honey
The bad stability of ball, shortened shelf life.
Below it is only the preferred embodiment of the present invention, it is noted that above-mentioned preferred implementation is not construed as the present invention
Restriction, protection scope of the present invention should be as the criterion with claim limited range.Ordinary skill for the art
For personnel, without departing from the spirit and scope of the present invention, it is also possible to make some improvements and modifications, these improvements and modifications
Also should be regarded as protection scope of the present invention.
Claims (8)
1. the Chinese medicine composition of a loosening bowel to relieve constipation, it is characterised in that include following weight portion meter prepares raw material: Semen Armeniacae Amarum
6～12 parts, Semen Persicae 6～12 parts, Fructus Cannabis 3～8 parts, Semen pini koraiensis 3～8 parts, Semen Pruni 3～8 parts and Pericarpium Citri tangerinae 2～6 parts.
The Chinese medicine composition of loosening bowel to relieve constipation the most according to claim 1, it is characterised in that include following weight portion meter
Prepare raw material: Semen Armeniacae Amarum 8 parts, 7 parts of Semen Persicae, Fructus Cannabis 6 parts, Semen pini koraiensis 6 parts, Semen Pruni 6 parts and Pericarpium Citri tangerinae 4 parts.
The Chinese medicine composition of loosening bowel to relieve constipation the most according to claim 1 and 2, it is characterised in that described Chinese medicine composition
Also include Semen Nelumbinis 4～7 parts, Bulbus Lilii 3～6 parts, Fructus Lycii 3～6 parts and Rhizoma Zingiberis Recens 2～5 parts.
The Chinese medicine composition of loosening bowel to relieve constipation the most according to claim 3, it is characterised in that described Chinese medicine composition also wraps
Include 6 parts of Semen Nelumbinis, Bulbus Lilii 5 parts, Fructus Lycii 5 parts and 3 parts of Rhizoma Zingiberis Recens.
5. according to the Chinese medicine composition of the arbitrary described loosening bowel to relieve constipation of Claims 1 to 4, it is characterised in that described Chinese medicine composition
Thing is granule, capsule, oral liquid and pill.
The preparation method of the Chinese medicine composition of loosening bowel to relieve constipation the most according to claim 3, it is characterised in that include following
Step:
S1, take the Semen Armeniacae Amarum of formula ratio, Semen Persicae, Fructus Cannabis, Semen pini koraiensis and Semen Pruni mixing, pulverize, cross 10 mesh sieves, add
Enter the water of 4～6 times of medical material amounts, soak 1.5～2h, filter, be subsequently added into the ethanol of 6～9 times of medical material amounts, in ultrasonic frequency
Being 30～40kHz, power is 200～300W, and Extracting temperature is to extract 1～2 time at 40～50 DEG C, each 30～40min, mistake
Filter, merging filtrate, filter vacuum is evaporated to the 1/4～1/3 of original volume, prepares concentrated solution A；
S2, take the Pericarpium Citri tangerinae of formula ratio, pulverize, cross 10 mesh sieves, add the water of 3～6 times of medical material amounts, reflux, extract, 1～2h, mistake
Filter, filter vacuum is evaporated to the 1/4～1/3 of original volume, prepares Pericarpium Citri tangerinae concentrated solution；
S3, take the Semen Nelumbinis of formula ratio, Bulbus Lilii and Fructus Lycii mixing, pulverized 10 mesh sieves, and added the water of 4～7 times of medical material amounts, and returned
Stream extracts 2～3h, filters, and filter vacuum is evaporated to the 1/4～1/3 of original volume, prepares concentrated solution B；
S4, take the Rhizoma Zingiberis Recens of formula ratio, section, add the ethanol of 2～4 times of medical material amounts, reflux, extract, 1～2h, filter, filtrate
Vacuum-concentrcted, to the 1/4～1/3 of original volume, prepares Rhizoma Zingiberis Recens concentrated solution；
S5, by described concentrated solution A, Pericarpium Citri tangerinae concentrated solution, concentrated solution B and Rhizoma Zingiberis Recens concentrated solution mix, mixed liquor is at vacuum decompression
Being concentrated into relative density at 60 DEG C is the extractum of 1.10～1.20, drying under reduced pressure, pulverizes, and prepares the Chinese medicine composition of loosening bowel to relieve constipation.
The preparation method of the Chinese medicine composition of loosening bowel to relieve constipation the most according to claim 6, it is characterised in that described step
In S1, the concentration of volume percent of ethanol is 90～95%.
The preparation method of the Chinese medicine composition of loosening bowel to relieve constipation the most according to claim 6, it is characterised in that described step
In S4, the concentration of volume percent of ethanol is 60～70%.
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106509273A (en) * | 2016-11-23 | 2017-03-22 | 西宁志培知识产权咨询有限公司 | Laxative substitutional tea prepared from food plants serving as components |
| CN107050351A (en) * | 2017-03-02 | 2017-08-18 | 江苏康缘药业股份有限公司 | A kind of Chinese medicine composition relaxed bowel and preparation method and application |
| CN109090612A (en) * | 2018-11-02 | 2018-12-28 | 杭州璧华生物科技有限公司 | A kind of Chinese medicinal food and preparation method of relax bowel and defecation |
| CN109393124A (en) * | 2018-12-17 | 2019-03-01 | 海南诗博丽生物科技有限公司 | A kind of dendrobium nobile bowel tea and preparation method thereof |
| CN110477330A (en) * | 2019-08-20 | 2019-11-22 | 广东伊家汤药品有限公司 | One kind helps digestion rouge soup product and preparation method thereof |
| CN111802641A (en) * | 2020-06-09 | 2020-10-23 | 刘淑云 | Composition with effect of relaxing bowel and preparation method and application thereof |
| CN115120683A (en) * | 2021-03-25 | 2022-09-30 | 海德尔(北京)保健食品有限公司 | Raw material composition, traditional Chinese medicine fermentation product, preparation method and application thereof |
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106509273A (en) * | 2016-11-23 | 2017-03-22 | 西宁志培知识产权咨询有限公司 | Laxative substitutional tea prepared from food plants serving as components |
| CN107050351A (en) * | 2017-03-02 | 2017-08-18 | 江苏康缘药业股份有限公司 | A kind of Chinese medicine composition relaxed bowel and preparation method and application |
| CN107050351B (en) * | 2017-03-02 | 2020-08-21 | 江苏康缘药业股份有限公司 | Traditional Chinese medicine composition for relaxing bowel and preparation method and application thereof |
| CN109090612A (en) * | 2018-11-02 | 2018-12-28 | 杭州璧华生物科技有限公司 | A kind of Chinese medicinal food and preparation method of relax bowel and defecation |
| CN109393124A (en) * | 2018-12-17 | 2019-03-01 | 海南诗博丽生物科技有限公司 | A kind of dendrobium nobile bowel tea and preparation method thereof |
| CN110477330A (en) * | 2019-08-20 | 2019-11-22 | 广东伊家汤药品有限公司 | One kind helps digestion rouge soup product and preparation method thereof |
| CN111802641A (en) * | 2020-06-09 | 2020-10-23 | 刘淑云 | Composition with effect of relaxing bowel and preparation method and application thereof |
| CN115120683A (en) * | 2021-03-25 | 2022-09-30 | 海德尔(北京)保健食品有限公司 | Raw material composition, traditional Chinese medicine fermentation product, preparation method and application thereof |
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