CN107050351A - A kind of Chinese medicine composition relaxed bowel and preparation method and application - Google Patents
A kind of Chinese medicine composition relaxed bowel and preparation method and application Download PDFInfo
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/64—Orobanchaceae (Broom-rape family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
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- A61K36/752—Citrus, e.g. lime, orange or lemon
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
- A61K36/8998—Hordeum (barley)
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
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Abstract
The invention discloses a kind of Chinese medicine composition relaxed bowel, it is prepared from by the raw material of following parts by weight：8~20 parts of 10~30 parts of saline cistanche, 20~40 parts of Semen sesami nigrum, 5~18 parts of fructus cannabis, 5~15 parts of brush-cherry seed, 5~15 parts of dried orange peel and malt.The invention also discloses application of the Chinese medicine composition in the medicine or health products with effect of relaxing bowel is prepared.The invention also discloses the medical extract for treating constipation containing the Chinese medicine composition.Chinese medicine composition of the present invention has rational formula, and each component is indispensable, and saline cistanche is the medicine of kidney channel blood system in side, with warming and invigorating kidney Yang, the effect of enriching the blood to restore normal menstruation, yang-tonifying gas is without dry, yin-nourishing blood and it is oiliness, be monarch drug in a prescription, brush-cherry seed is longer than laxation defaecation, and energy diuresis, fructus cannabis, which is nourished, to be moisturized, and effect relaxes, the two is combined into ministerial drug, Semen sesami nigrum yin-nourishing blood, nourishing liver kidney, dried orange peel regulating qi-flowing for strengthening spleen, malt helps digestion, and makes altogether for assistant.Six medicine compatibilities are used, and are mutually promoted, the strength enhancing of laxation defaecation.
Description
Technical field
The invention belongs to technical field of health care food, it is related to a kind of Chinese medicine composition and preparation method and application, especially
It is related to a kind of composition relaxed bowel and preparation method and application.
Background technology
With the continuous quickening and the change of eating habit of rhythm of life, constipation turns into mid-aged population and working clan
Common disease, and in the trend of rejuvenation.Constipation is primarily referred to as that defecation frequency is reduced, excrement amount is reduced, excrement is dry and hard, defecation expense
Power etc..The reason for constipation is that big gut function conduction is not normal, and stomach and intestine accumulated heat, body fluid being damaged, large intestine is dry and hard, causes to suffer from constipation,
Holdup time length in enteron aisle and it is constipated.Harm of the constipation to human body is larger, during constipation, difficult defecation, and excrement is dried, quiet at anus
Arteries and veins is suffered oppression and easily forms hemorrhoid, and difficult defecation, and selection is exerted just, easily causes anal fissure and cardiovascular and cerebrovascular disease, also
Rectitis can be caused.While constipation patient mood lather, notice laxes, influence daily life and work.Some patients
In order to solve difficult defecation, take cathartic or use herbal enema, but can not all solve root problem.Therefore, ease constipation is developed
The health food of defaecation is significant.
The content of the invention
It is an object of the invention to provide a kind of Chinese medicine composition relaxed bowel and preparation method and application, the Chinese medicine
Composition, which has, to be relaxed bowel, and kidney tonifying is moisturized, effect of regulating qi-flowing for strengthening spleen, also with preparation technology is simple, good effect, easy to spread
The advantages of.
The purpose of the present invention can be achieved through the following technical solutions：
A kind of Chinese medicine composition relaxed bowel, the Chinese medicine composition is prepared from by the raw material of following parts by weight：Meat
10~30 parts of desert cistanche, 20~40 parts of Semen sesami nigrum, 5~18 parts of fructus cannabis, 5~15 parts of brush-cherry seed, 5~15 parts of dried orange peel and malt 8~
20 parts.
It is preferred that, described Chinese medicine composition is prepared from by the raw material of following parts by weight：It is 10~30 parts of saline cistanche, black
10~20 parts of 25~40 parts of sesame, 5~15 parts of fructus cannabis, 5~15 parts of brush-cherry seed, 5~15 parts of dried orange peel and malt.
It is further preferred that described Chinese medicine composition is prepared from by the raw material of following parts by weight：Saline cistanche 10~
10~15 parts of 20 parts, 25~35 parts of Semen sesami nigrum, 5~15 parts of fructus cannabis, 5~10 parts of brush-cherry seed, 5~10 parts of dried orange peel and malt
Specifically, Chinese medicine composition of the present invention is prepared from by the raw material of following parts by weight：It is 10 parts of saline cistanche, black
10 parts of 25 parts of sesame, 5 parts of fructus cannabis, 5 parts of brush-cherry seed, 5 parts of dried orange peel and malt；Or 30 parts of saline cistanche, 40 parts of Semen sesami nigrum, fructus cannabis
20 parts of 15 parts, 15 parts of brush-cherry seed, 15 parts of dried orange peel and malt；Or 20 parts of saline cistanche, 30 parts of Semen sesami nigrum, 10 parts of fructus cannabis, brush-cherry seed 8
15 parts of part, 6 parts of dried orange peel and malt.
The preparation method of described Chinese medicine composition, it is characterised in that comprise the following steps：
(1) crush：By Semen sesami nigrum, the frying of brush-cherry seed difference slow fire, play powder, sieving；Fructus cannabis is played into powder, sieving；
(2) extract：Saline cistanche, dried orange peel, malt are eluted with water, merged, the pure water of 8~12 times of medicinal material total amount is added,
Extract 1~3 time, 1~3h every time, 200~400 mesh screens after extract solution cooling；
(3) concentrate：Filtrate is heated to boiling, uses slow fire instead, is stirred continuously and is concentrated into 3/5ths of former filtrate volume, stop
Only heat, concentrate is standby；
(4) mix, stir：Semen sesami nigrum, fructus cannabis, brush-cherry seed powder are added in concentrate, slow fire heating is stirred continuously,
Flag is hung to stirring rod concoction is lifted, stops heating and produces paste composition.
In step (1), Semen sesami nigrum, brush-cherry seed and fructus cannabis, which are beaten, crosses 60~80 mesh sieves after powder.
Chinese medicine composition of the present invention has effects that to relax bowel, therefore it is a further object to provide
Application of the described Chinese medicine composition in the medicine or health products with effect of relaxing bowel is prepared.
A kind of relax bowel medicine or health products containing Chinese medicine composition of the present invention, using the Chinese medicine composition as
Active ingredient, adds medically acceptable auxiliary material, clinically-acceptable formulation is made.It is preferred that, the formulation of described medicine
For paste.
Described medical extract for treating constipation is made by following methods：Saline cistanche, dried orange peel, malt are eluted with water, merged, medicine is added
The pure water that 8~12 times of material total amount, is extracted 1~3 time, 1~3h, cooled and filtered, merging filtrate every time；Filtrate is heated to boiling
After use slow fire concentration instead, until being concentrated into 3/5ths of former filtrate volume, stop heating；Into concentrate add Semen sesami nigrum,
Fructus cannabis, brush-cherry seed powder, slow fire heating, are stirred continuously, and flag is hung to stirring rod concoction is lifted, and are stopped heating and are produced paste；Sterilizing,
Filling, medical extract for treating constipation finished product is made in two-stage sterilization.
It is another object of the present invention to provide the preparation method of described medical extract for treating constipation, following step is included：
(1) crush：By Semen sesami nigrum, the frying of brush-cherry seed difference slow fire, play powder, sieving；Fructus cannabis is played into powder, sieving；
(2) extract：Saline cistanche, dried orange peel, malt are eluted with water, merged, the pure of 8~12 times of amounts of medicinal material total amount is added
Water, water boiling and extraction 1~3 time, every time 1~3h, 200~400 mesh screens after extract solution cooling；
(3) concentrate：Filtrate is heated to boiling, uses slow fire instead, is stirred continuously and is concentrated into 3/5ths of former filtrate volume, stop
Only heat, concentrate is standby；
(4) mix, stir：Semen sesami nigrum, fructus cannabis, brush-cherry seed powder are added in concentrate, slow fire heating is stirred continuously,
Flag is hung to stirring rod concoction is lifted, stops heating and produces paste；
(5) sterilize：120~150 DEG C of 10~40s of high temperature sterilization of paste that step (4) is obtained；
(6) it is filling：36~40 DEG C are cooled to, vacuum filling machine is filling, capping；
(7) two-stage sterilization：Sterilized 15~30 minutes at 80~90 DEG C using sterilization kettle, medical extract for treating constipation finished product is made.
120~150 DEG C of slow fire temperature in the present invention.
Beneficial effects of the present invention：
The Chinese medicine composition that the present invention is provided has rational formula, and wherein each component is indispensable, saline cistanche kidney tonifying benefit
Essence, relaxes bowel, and Semen sesami nigrum filling liver kidney, benefiting essence-blood, ease constipation are dry, and fructus cannabis, brush-cherry seed relax bowel, and dried orange peel qi-regulating is with, wheat
Bud promoting the circulation of qi helps digestion.Deficiency of kidney-QI, body fluid is withered few, causes the dysfunction of the spleen in transport, and large intestine is dry and astringent, transmits powerless and sends out as constipation.Meat desert in side
Rong is the medicine of kidney channel blood system, with warming and invigorating kidney Yang, the effect of enriching the blood to restore normal menstruation, yang-tonifying gas without dry, yin-nourishing blood and it is oiliness, be monarch drug in a prescription,
Brush-cherry seed is longer than laxation defaecation, and energy diuresis, and fructus cannabis, which is nourished, to be moisturized, and effect relaxes, and the two is combined into ministerial drug, Semen sesami nigrum yin-nourishing
Blood, nourishing liver kidney, dried orange peel regulating qi-flowing for strengthening spleen, malt help digestion, made altogether for assistant.Six medicine compatibilities are used, and are mutually promoted, the strength of laxation defaecation
Enhancing.
The Chinese medicine composition is made to have after paste and relaxed bowel, and kidney tonifying is moisturized, effect of regulating qi-flowing for strengthening spleen, also with preparation
Technique is simple, good effect, it is easy to spread the advantages of.
Embodiment
With reference to embodiment, the present invention will be further described, but protection scope of the present invention not limited to this.
Embodiment 1
From the raw material of following parts by weight：10 parts of saline cistanche, 25 parts of Semen sesami nigrum, 5 parts of fructus cannabis, 5 parts of brush-cherry seed, dried orange peel
5 parts and 10 parts of malt；Medical extract for treating constipation is made according to following preparation method：
(1) crush：By Semen sesami nigrum, the frying of brush-cherry seed difference slow fire, powder is beaten, fructus cannabis is beaten into powder, 60 mesh sieves are crossed；
(2) extract：Saline cistanche, dried orange peel, malt are eluted with water, merged, the pure water of 8 times of medicinal material total amount, decocting is added
Boil extraction 1 time, each 1h, 200 mesh screens after extract solution cooling；
(3) concentrate：Filtrate is heated to boiling, uses slow fire instead, is stirred continuously and is concentrated into 3/5ths of former filtrate volume, stop
Only heat, concentrate is standby；
(4) mix, stir：Semen sesami nigrum, fructus cannabis, brush-cherry seed powder are added in concentrate, slow fire heating is stirred continuously,
Flag is hung to stirring rod concoction is lifted, stops heating and produces paste；
(5) sterilize：The paste that step (4) is obtained is placed in container, by high temperature sterilization, and temperature is 150 DEG C, and the time is
10s；
(6) it is filling：36 DEG C are cooled to, vacuum filling machine is filling, capping；
(7) two-stage sterilization：Sterilized 15 minutes at 90 DEG C using sterilization kettle, medical extract for treating constipation finished product is made.
Embodiment 2
From the preparing raw material of following parts by weight：30 parts of saline cistanche, 40 parts of Semen sesami nigrum, 15 parts of fructus cannabis, brush-cherry seed 15
20 parts of part, 15 parts of dried orange peel and malt；Medical extract for treating constipation is made according to following preparation method：
(1) crush：By Semen sesami nigrum, the frying of brush-cherry seed difference slow fire, powder is beaten, fructus cannabis is beaten into powder, 80 mesh sieves are crossed；
(2) extract：Saline cistanche, dried orange peel, malt are eluted with water, merged, the pure water of 10 times of medicinal material total amount, decocting is added
Boil extraction 2 times, each 2h, 400 mesh screens after extract solution cooling；
(3) concentrate：Filtrate is heated to boiling, uses slow fire instead, is stirred continuously and is concentrated into 3/5ths of former filtrate volume, stop
Only heat, concentrate is standby；
(4) mix, stir：Semen sesami nigrum, fructus cannabis, brush-cherry seed powder are added in concentrate, slow fire heating is stirred continuously,
Flag is hung to stirring rod concoction is lifted, stops heating and produces paste；
(5) sterilize：The paste that step (4) is obtained is placed in container, by high temperature sterilization, and temperature is 120 DEG C, and the time is
30s；
(6) it is filling：40 DEG C are cooled to, vacuum filling machine is filling, capping；
(7) two-stage sterilization：Sterilized 30 minutes at 80 DEG C using sterilization kettle, medical extract for treating constipation finished product is made.
Embodiment 3
From the preparing raw material of following parts by weight：20 parts of saline cistanche, 30 parts of Semen sesami nigrum, 10 parts of fructus cannabis, brush-cherry seed 8
15 parts of part, 6 parts of dried orange peel and malt；Medical extract for treating constipation is made according to following preparation method：
(1) crush：By Semen sesami nigrum, the frying of brush-cherry seed difference slow fire, powder is beaten, fructus cannabis is beaten into powder, 65 mesh sieves are crossed；
(2) extract：Saline cistanche, dried orange peel, malt are eluted with water, merged, the pure water of 12 times of medicinal material total amount, decocting is added
Boil extraction 3 times, each 3h, 300 mesh screens after extract solution cooling；
(3) concentrate：Filtrate is heated to boiling, uses slow fire instead, is stirred continuously and is concentrated into 3/5ths of former filtrate volume, stop
Only heat, concentrate is standby；
(4) mix, stir：Semen sesami nigrum, fructus cannabis, brush-cherry seed powder are added in concentrate, slow fire heating is stirred continuously,
Flag is hung to stirring rod concoction is lifted, stops heating and produces paste；
(5) sterilize：The paste that step (4) is obtained is placed in container, by high temperature sterilization, and temperature is 140 DEG C, and the time is
40s；
(6) it is filling：38 DEG C are cooled to, vacuum filling machine is filling, capping；
(7) two-stage sterilization：Sterilized 20 minutes at 85 DEG C using sterilization kettle, medical extract for treating constipation finished product is made.
Animal function test
Small intestine push is tested
1. packet is set with dosage：Take 210 kunming mices, after adaptability is fed 5 days, it is normal right to be randomly divided into by body weight
According to group, model control group, low dose group (0.5g/kg body weight), high dose group (1.0g/kg body weight), 17 side of tearing open group (2.0g/
Kg body weight) totally 21 groups.Each group specifying information is as follows：
Low dose group：Embodiment 1 (0.5g/kg body weight)；
High dose group：Embodiment 1 (1.0g/kg body weight)；
A1 groups：10 parts of saline cistanche (2.0g/kg body weight)；
A2 groups：5 parts of fructus cannabis (2.0g/kg body weight)；
A3 groups：5 parts of dried orange peel (2.0g/kg body weight)；
A4 groups：5 parts of brush-cherry seed (2.0g/kg body weight)；
A5 groups：25 parts of Semen sesami nigrum (2.0g/kg body weight)；
A6 groups：10 parts of malt (2.0g/kg body weight)；
A7 groups：10 parts of saline cistanche, 25 parts of Semen sesami nigrum (2.0g/kg body weight)；
A8 groups：10 parts of saline cistanche, 5 parts of fructus cannabis (2.0g/kg body weight)；
A9 groups：10 parts of saline cistanche, 5 parts of brush-cherry seed (2.0g/kg body weight)；
A10 groups：5 parts of brush-cherry seed, 5 parts of dried orange peel (2.0g/kg body weight)；
A11 groups：10 parts of saline cistanche, 5 parts of fructus cannabis, 5 parts of brush-cherry seed (2.0g/kg body weight)；
A12 groups：10 parts of saline cistanche, 5 parts of fructus cannabis, 5 parts of dried orange peel (2.0g/kg body weight)；
A13 groups：10 parts of saline cistanche, 25 parts of Semen sesami nigrum, 5 parts of fructus cannabis (2.0g/kg body weight)；
A14 groups：10 parts of saline cistanche, 5 parts of brush-cherry seed, 10 parts of malt (2.0g/kg body weight)；
A15 groups：10 parts of saline cistanche, 25 parts of Semen sesami nigrum, 5 parts of fructus cannabis, 5 parts of brush-cherry seed (2.0g/kg body weight)；
A16 groups：10 parts of saline cistanche, 25 parts of Semen sesami nigrum, 5 parts of fructus cannabis, 5 parts of brush-cherry seed, 5 parts of dried orange peel (2.0g/kg body weight)；
A17 groups：10 parts of saline cistanche, 25 parts of Semen sesami nigrum, 5 parts of fructus cannabis, 5 parts of brush-cherry seed, 10 parts of (2.0g/kg bodies of malt
Weight)；
2. modelling and administration：Every group of mouse 10, during experiment, low dose group, high dose group, respectively the side of tearing open group respectively by
20ml/kgbw gavages give each tested material, and the equal gavage of Normal group, model control group gives isometric distilled water, daily 1
It is secondary, continuous 14 days.After each group fasting 24 hours, Normal group gives isometric distilled water, and remaining each group respectively give by gavage
R-1132 (10mg/kg), is replicated after Constipated mice, modeling 30min, gavage gives prepared Chinese ink to each group respectively
(0.1ml/10g).Cervical dislocation puts to death animal after 20min, opens abdominal cavity separation mesenterium, clip upper end is from pylorus, lower end
To the intestinal tube of ileocecus, small intestine is gently pulled into straight line, measurement Length of intestine is " total small intestinal length ", from pylorus to prepared Chinese ink forward position
For " prepared Chinese ink propulsion length ", ink progradation is calculated：
Ink progradation (%)=(prepared Chinese ink promotes length/total small intestinal length) × 100%
As a result it is as shown in table 1 below：
Influence of the sample of table 1 to mice with constipation Small intestine advance activity
| Packet | Ink progradation (%) |
| Normal group | 61.5±3.5 |
| Model control group | 35.8±4.1## |
| Low dose group | 59.2±2.9** |
| High dose group | 60.1±3.1** |
| Saline cistanche group | 36.9±5.2ΔΔ |
| Fructus cannabis group | 36.3±4.0ΔΔ |
| Dried orange peel group | 35.9±3.1ΔΔ |
| Brush-cherry seed group | 36.5±6.0ΔΔ |
| Semen sesami nigrum group | 36.6±2.2ΔΔ |
| Malt group | 35.9±5.3ΔΔ |
| Saline cistanche+Semen sesami nigrum group | 38.2±3.9ΔΔ |
| Saline cistanche+fructus cannabis group | 38.5±2.0ΔΔ |
| Saline cistanche+brush-cherry seed group | 38.1±5.5ΔΔ |
| Brush-cherry seed+dried orange peel group | 37.9±6.2ΔΔ |
| Saline cistanche+fructus cannabis+brush-cherry seed group | 39.5±3.8ΔΔ |
| Saline cistanche+fructus cannabis+dried orange peel group | 39.3±5.0ΔΔ |
| Saline cistanche+fructus cannabis+Semen sesami nigrum group | 39.1±5.6ΔΔ |
| Fructus cannabis+brush-cherry seed+malt group | 39.4±3.7ΔΔ |
| Saline cistanche+fructus cannabis+brush-cherry seed+Semen sesami nigrum group | 39.9±2.5ΔΔ |
| Saline cistanche+fructus cannabis+brush-cherry seed+Semen sesami nigrum+dried orange peel group | 40.2±3.3ΔΔ |
| Saline cistanche+fructus cannabis+brush-cherry seed+Semen sesami nigrum+malt group | 40.5±1.9ΔΔ |
Note：Compared with Normal group,##p<0.01
Compared with model group, * * p<0.01
Compared with low dose group,ΔΔp<0.01
Compared with Normal group, the ink progradation of model group substantially reduces (p<0.01) modeling success, is illustrated.With mould
Type group is compared, and sample is low, high dose group ink progradation substantially increases, and difference is very significant (p<0.01), show
Sample is remarkably improved small intestine push type wriggling to mice with constipation, and respectively the side's of tearing open group is failed to understand the Constipation of mice with constipation
It is aobvious, no difference of science of statistics (p>0.05).Compared with low dose group, respectively the ink progradation of the side's of tearing open group substantially reduces (p<0.01),
Illustrate that present composition paste has the effect that small intestine push type is wriggled that improves, effect is better than the side's of tearing open group.
Clinical observation on the therapeutic effect
1. case selection：In suffering from constipation clinical volunteers patient at 300, male patient 180, female patient 120,
Age bracket 18-60 Sui, average age is 39, all patients no difference of science of statistics in sex, age, the course of disease.
2. efficacy assessment standard：
Cure：Defecation 1 time within 2 days, just matter turn profit, unobstructed during solution, in short term without recurrence；
It is effective：Defecation within 3 days, just matter turn profit, defecation owes smooth；
Effectively：Defecation within 3 to 4 days；
It is invalid：Symptom is without improvement；
Total effective rate=(cure+effective+effectively)/total number of cases × 100%
Instructions of taking：300 patients are randomly divided into 4 groups, every group of 75 people respectively treat A groups, treatment B groups, treatment C
Group and control group, treatment A groups, treatment B groups, treatment component C do not take the paste that the embodiment of the present invention 1,2,3 is prepared, often
Day 2 times, each 10g, oral one week, one week be a course for the treatment of；Control group takes desert cistanche oral liquid as cathartics (Tianshui city Chinese medicine medicine
Industry Co., Ltd, Chinese medicines quasi-word Z10910032), orally, a 1-2 branch 1 times a day, is taken one week.
3. treatment results are as shown in table 2：
The treatment results of table 2
| Group | Number/people | Cure (rate) | It is effective | Effectively | It is invalid | Total effective rate (%) |
| Treat A groups | 75 | 62 (82.7%) | 3 | 4 | 6 | 92.0% |
| Treat B groups | 75 | 63 (84.0%) | 5 | 2 | 5 | 93.3% |
| Treat C groups | 75 | 65 (86.7%) | 4 | 3 | 3 | 96.0% |
| Control group | 75 | 45 (60.0%) | 4 | 5 | 21 | 72.0% |
Using desert cistanche oral liquid as cathartics as a control group, desert cistanche oral liquid as cathartics has the effect relaxed bowel for this experiment,
For elderly constipation, puerperal constipation.The cure rate of Chinese medicine preparation of the present invention reaches more than 80.0%, and total effective rate reaches 90.0%
More than, higher than the cure rate and total effective rate of control group, wherein best with the therapeutic effect for treating C groups, it is seen then that paste of the present invention
Good effect, cure rate is high, can be used as the medicine relaxed bowel.
Model case
Case 1：Hu, female, 23 years old, abdominal distension, normal constipation, once weak, the often sense giddy, appetite in 6-8 days of general stool
Difference, tongue talks that tongue is few, and thready and soft pulse takes the 2nd day unobstructed defecation after the Chinese medicine of the embodiment of the present invention 1, after continue to take 1 week, and combine
Moderate exercise, eats vegetable and fruit more, and stool is very normal always later, recovery from illness.
Case 2：Zhang, man, 36 years old, company clerk, because of long-term sitting, lacked motion, adds the pungent meat or fish of dietary preferences
Raw meat, causes constipation for many years.Start in March, 2014 to take the Chinese medicine of the embodiment of the present invention 2, next day discharges a large amount of stools, a week
Afterwards, the stool of discharge is neither too hard, nor too soft, after one month, forms the custom of daily timing defecation.
Case 3：Mr. Li, female, 45 years old, dry and hard excrement was difficult lower 5 years, and 4-6 days a line take enema defaecation, and disease：It is weary
Power, dry, sallow complexion is simple and unadorned, cheek blackspot, chilly, do not feel like eating, dry cool drink, and symptom autumn and winter aggravates, tongue nature
Dimness, tongue fur is white, small and wiry pulse.It is diagnosed as empty secret, the rules for the treatment of nourishing Yin and moistening dryness, nourishing qi and blood of yang blood and qi all void.Take the present invention
The Chinese medicine of embodiment 3, took after 2 days, and smooth, a line on the 2nd of defecating, dry takes a turn for the better, continues to take after one month, and all diseases disappear, greatly
Just normal, a line on the one is had rosy cheeks, recovery from illness.
Claims (10)
1. a kind of Chinese medicine composition, it is characterised in that the Chinese medicine composition is prepared from by the raw material of following parts by weight：Meat desert
10~30 parts of Rong, 20~40 parts of Semen sesami nigrum, 5~18 parts of fructus cannabis, 5~15 parts of brush-cherry seed, 5~15 parts of dried orange peel and malt 8~20
Part.
2. Chinese medicine composition according to claim 1, it is characterised in that described Chinese medicine composition is by following parts by weight
Raw material be prepared from：10~30 parts of saline cistanche, 25~40 parts of Semen sesami nigrum, 5~15 parts of fructus cannabis, 5~15 parts of brush-cherry seed, dried orange peel
5~15 parts and 10~20 parts of malt.
3. Chinese medicine composition according to claim 2, it is characterised in that described Chinese medicine composition is by following parts by weight
Raw material be prepared from：10~20 parts of saline cistanche, 25~35 parts of Semen sesami nigrum, 5~15 parts of fructus cannabis, 5~10 parts of brush-cherry seed, dried orange peel
5~10 parts and 10~15 parts of malt.
4. the Chinese medicine composition described in claim 1,2 or 3 is in the medicine or health products with effect of relaxing bowel is prepared
Using.
5. the preparation method of the Chinese medicine composition described in claim 1,2 or 3, it is characterised in that comprise the following steps：
(1) crush：By Semen sesami nigrum, the frying of brush-cherry seed difference slow fire, play powder, sieving；Fructus cannabis is played into powder, sieving；
(2) extract：Saline cistanche, dried orange peel, malt are eluted with water, merged, the pure water of 8~12 times of medicinal material total amount, decocting is added
Extraction 1~3 time is boiled, every time 1~3h, 200~400 mesh screens after extract solution cooling；
(3) concentrate：Filtrate is heated to boiling, uses slow fire instead, is stirred continuously and is concentrated into 3/5ths of former filtrate volume, stops adding
Heat, concentrate is standby；
(4) mix, stir：Semen sesami nigrum, fructus cannabis, brush-cherry seed are added in concentrate, slow fire heating is stirred continuously, to lifting
Stirring rod concoction hangs flag, stops heating and produces paste composition.
6. a kind of relax bowel medicine or the health products of the Chinese medicine composition containing described in claim 1,2 or 3, it is characterised in that
Using the Chinese medicine composition as active ingredient, medically acceptable auxiliary material is added, clinically-acceptable formulation is made.
7. medicine or the health products according to claim 6 of relaxing bowel, it is characterised in that the formulation of described medicine is cream
Agent.
8. a kind of medical extract for treating constipation, it is characterised in that the paste contains the Chinese medicine composition described in claim 1,2 or 3.
9. medical extract for treating constipation according to claim 8, it is characterised in that described medical extract for treating constipation is made by following methods：
Saline cistanche, dried orange peel, malt are eluted with water, merged, the pure water of 8~12 times of medicinal material total amount is added, 1~3 time is extracted, every time 1
~3h, cooled and filtered, merging filtrate；Filtrate is heated to using slow fire concentration after boiling instead, until being concentrated into former filtrate volume
3/5ths, stop heating；Semen sesami nigrum, fructus cannabis, brush-cherry seed powder are added into concentrate, slow fire heating is stirred continuously, to carrying
Play stirring rod concoction and hang flag, stop heating and produce paste；Medical extract for treating constipation finished product is made in sterilizing, filling, two-stage sterilization.
10. the preparation method of the medical extract for treating constipation described in claim 8, it is characterised in that comprise the following steps：
(1) crush：By Semen sesami nigrum, the frying of brush-cherry seed difference slow fire, play powder, sieving；Fructus cannabis is played into powder, sieving；
(2) extract：Saline cistanche, dried orange peel, malt are eluted with water, merged, the pure water of 8~12 times of amounts of medicinal material total amount is added, carries
Take 1~3 time, every time 1~3h, 200~400 mesh screens after extract solution cooling；
(3) concentrate：Filtrate is heated to boiling, uses slow fire instead, is stirred continuously and is concentrated into 3/5ths of former filtrate volume, stops adding
Heat, concentrate is standby；
(4) mix, stir：Semen sesami nigrum, fructus cannabis, brush-cherry seed powder are added in concentrate, slow fire heating is stirred continuously, to carrying
Play stirring rod concoction and hang flag, stop heating and produce paste；
(5) sterilize：120~150 DEG C of 10~40s of high temperature sterilization of paste that step (4) is obtained；
(6) it is filling：36~40 DEG C are cooled to, vacuum filling machine is filling, capping；
(7) two-stage sterilization：Sterilized 15~30 minutes at 80~90 DEG C using sterilization kettle, medical extract for treating constipation finished product is made.
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| CN108524646A (en) * | 2018-07-04 | 2018-09-14 | 江苏康缘药业股份有限公司 | A kind of composition and the preparation method and application thereof with function of relaxing bowel |
| CN113181292A (en) * | 2021-05-20 | 2021-07-30 | 南京正宽医药科技有限公司 | Traditional Chinese medicine composition for treating constipation |
| CN114732784B (en) * | 2022-05-10 | 2023-04-14 | 山东中医药大学 | Qi-tonifying yang-warming bowel-relaxing oral liquid and preparation process thereof |
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| CN108524646B (en) * | 2018-07-04 | 2021-02-12 | 江苏康缘药业股份有限公司 | Composition with bowel relaxing function and preparation method and application thereof |
| CN113181292A (en) * | 2021-05-20 | 2021-07-30 | 南京正宽医药科技有限公司 | Traditional Chinese medicine composition for treating constipation |
| CN114732784B (en) * | 2022-05-10 | 2023-04-14 | 山东中医药大学 | Qi-tonifying yang-warming bowel-relaxing oral liquid and preparation process thereof |
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