CN109985115B

CN109985115B - Traditional Chinese medicine tea bag for treating constipation

Info

Publication number: CN109985115B
Application number: CN201910433550.5A
Authority: CN
Inventors: 朱平生; 苗明三; 朱正望; 焦炎杰; 孟玉; 郭佳佳
Original assignee: Henan University of Traditional Chinese Medicine HUTCM
Current assignee: Henan University of Traditional Chinese Medicine HUTCM
Priority date: 2019-05-23
Filing date: 2019-05-23
Publication date: 2021-07-23
Anticipated expiration: 2039-05-23
Also published as: CN109985115A

Abstract

The invention relates to a traditional Chinese medicine tea bag for treating constipation, which can effectively solve the problem of constipation and adopts the technical scheme that the traditional Chinese medicine tea bag is prepared from the following raw material medicines by weight: the Chinese medicinal composition is prepared by crushing fried cassia seed, fried radish seed, 13-17g sophora flower, 10-14g mulberry, 1-5g fried lotus plumule, 10-14g fennel, 10-14g dried orange peel, 10-14g peach blossom, 10-14g dandelion and 10-14g fried bunge cherry seed into 5-10 mesh coarse powder, uniformly mixing and bagging.

Description

Traditional Chinese medicine tea bag for treating constipation

Technical Field

The invention relates to the field of traditional Chinese medicines, in particular to a traditional Chinese medicine tea bag for treating constipation.

Background

The constipation is a common clinical intractable disease caused by weak defecation and retained feces due to the reduction of intestinal peristalsis power, generally has a long course of disease, is recurrent and persistent, and brings great trouble to the working life of patients. The traditional Chinese medicine composition is a common digestive system disease, has a long course of disease and is difficult to cure, and the main clinical symptoms of the traditional Chinese medicine composition comprise reduction of defecation frequency, dry feces and difficult defecation, and are difficult to treat, so that intestinal microecological imbalance is frequently caused, the risk of inducing intestinal cancer is increased, and the life quality of people is seriously influenced. Modern medicine has no clear understanding on the cause of constipation, and an effective treatment method is lacked, and at present, western medicine treatment mostly adopts drug treatment, mainly comprises various prokinetic drugs, hypertonic cathartic drugs and the like, but the clinical curative effect is general, the state of an illness is easy to repeat, the side effect is obvious, dependence and intractable constipation occur even after long-term taking, and an effective treatment means is lacked. The traditional Chinese medicine has long-term knowledge on constipation, and the traditional Chinese medicine treatment is based on syndrome differentiation and treatment, has the unique advantages of definite and lasting curative effect and small side effect in treating the constipation, can be accepted by the public, and has important guiding significance in the aspect of developing new medicines for treating the constipation. Therefore, the development of a safe medicament with definite curative effect and small side effect is a technical problem which needs to be solved urgently at present.

Disclosure of Invention

In view of the above situation, the present invention aims to provide a traditional Chinese medicine teabag for treating constipation, which can effectively solve the problem of constipation.

The technical scheme of the invention is that the traditional Chinese medicine teabag is prepared from the following raw material medicines by weight: 13-17g of fried cassia seed, 13-17g of fried radish seed, 13-17g of sophora flower, 10-14g of mulberry, 1-5g of fried lotus plumule, 10-14g of fennel, 10-14g of dried orange peel, 10-14g of peach blossom, 10-14g of dandelion and 10-14g of fried bunge cherry seed, and the fried cassia seed, the fried radish seed, the sophora flower, the mulberry, the fried lotus plumule, the fennel, the dried orange peel, the peach blossom, the dandelion and the fried bunge cherry seed are crushed into 5-10-mesh coarse powder, mixed evenly and packaged into bags.

The traditional Chinese medicine composition has the advantages of rich raw materials, simple preparation method, scientific and reasonable compatibility, intestine moistening and bowel relaxing effects, development of a new way of medicine for treating constipation, convenience in taking and good effect, and is an innovation of the medicine for treating constipation.

Detailed Description

The following examples further illustrate the embodiments of the present invention in detail.

Example 1

When the invention is implemented, the invention can be prepared by the following raw material medicaments by weight: 15g of fried cassia seed, 15g of fried radish seed, 15g of sophora flower, 12g of mulberry, 3g of fried lotus plumule, 12g of fennel, 12g of dried orange peel, 12g of peach blossom, 12g of dandelion and 12g of fried bunge cherry seed, and the fried cassia seed, the fried radish seed, the sophora flower, the mulberry, the fried lotus plumule, the fennel, the dried orange peel, the peach blossom, the dandelion and the fried bunge cherry seed are crushed into coarse powder which is sieved by a 5-10 mesh sieve, mixed evenly and subpackaged into bags to obtain the Chinese patent medicine.

Example 2

When the invention is implemented, the invention can also be prepared from the following raw material medicaments in part by weight: 14g of fried cassia seed, 16g of fried radish seed, 14g of sophora flower, 13g of mulberry, 2g of fried lotus plumule, 13g of fennel, 11g of dried orange peel, 13g of peach blossom, 11g of dandelion and 13g of fried bunge cherry seed, and the fried cassia seed, the fried radish seed, the sophora flower, the mulberry, the fried lotus plumule, the fennel, the dried orange peel, the peach blossom, the dandelion and the fried bunge cherry seed are crushed into coarse powder which is sieved by a 5-10-mesh sieve, mixed evenly and subpackaged into bags to obtain the Chinese patent medicine.

Example 3

When the invention is implemented, the invention can also be prepared from the following raw material medicaments in part by weight: the Chinese medicine is prepared by crushing 16g of fried cassia seed, 14g of fried radish seed, 16g of sophora flower, 11g of mulberry, 4g of fried lotus plumule, 11g of fennel, 13g of dried orange peel, 11g of peach blossom, 13g of dandelion and 11g of fried bunge cherry seed into coarse powder which is sieved by a 5-10 mesh sieve, uniformly mixing, and subpackaging into bags.

In the formula of the invention, the formula comprises the following components:

parching semen Cassiae: clearing liver-fire, improving eyesight, suppressing liver yang, loosening bowel to relieve constipation; can be used for treating eye diseases, headache, vertigo, and constipation due to intestinal dryness.

Frying radish seeds: promoting digestion, relieving flatulence, descending qi and resolving phlegm; can be used for treating food stagnation, qi stagnation, cough, asthma, and excessive phlegm.

And (3) flos sophorae: cool blood to stop bleeding, clear liver heat and purge fire; can be used for treating hemorrhage due to blood heat, flaring up of liver fire, conjunctival congestion, headache, etc.

And (3) mulberry fruit: enriching blood and nourishing yin, promoting fluid production and moistening dryness; can be used for treating vertigo, tinnitus, palpitation, insomnia, premature gray hair, thirst due to body fluid consumption, internal heat, diabetes, blood deficiency, and constipation.

Frying the lotus plumule: clearing heart fire, tranquilizing mind, restoring normal coordination between heart and kidney, arresting seminal emission and stopping bleeding; can be used for treating pericardium heat invasion, coma, delirium, imbalance between heart and kidney, insomnia, spermatorrhea, blood heat, hematemesis, etc.

Fennel: dispel cold to stop pain, regulate qi and harmonize stomach; can be used for treating cold hernia with abdominal pain, dysmenorrhea, and qi stagnation due to cold accumulation in middle jiao.

Dried orange peel: regulating qi-flowing, invigorating spleen, eliminating dampness, and eliminating phlegm; can be used for treating spleen and stomach qi stagnation syndrome, damp phlegm, cold phlegm cough, etc. The product has effects in dilating bronchus, stimulating secretion of digestive juice, dilating blood vessel, lowering blood pressure, reducing cholesterol, promoting function of gallbladder, and relieving inflammation.

Peach blossom: purgation, relaxing bowels, inducing diuresis to alleviate edema; can be used for treating edema, ascites, constipation, etc. Has effects in dilating blood vessel, improving blood circulation, promoting skin nutrition and oxygen supply, and preventing melanin deposition.

Dandelion: clearing away heat and toxic materials, resolving carbuncle and resolving hard mass, and eliminating dampness and heat; can be used for treating sore and carbuncle due to heat-toxin, heat stranguria, and jaundice due to damp-heat.

Frying bunge cherry seeds: loosening bowel to relieve constipation, inducing diuresis to alleviate edema; can be used for treating constipation due to intestinal dryness, edema, and edema of loempe.

The invention has rich raw materials, easy production and preparation, mutual compatibility of the medicines, good efficacy of relaxing the bowels, unique curative effect on constipation, convenient and safe taking and good beneficial technical effect obtained by tests, and the relevant test data are as follows:

animal experiment data

1 materials of the experiment

1.1 Experimental animals

SPF grade KM mice 72, male, 18-22g, certification number: no.37009200017418, supplied by jinanpunyue laboratory animals breeding limited, license number: SCXK (lu) 20140007. License number used by experimental unit: SYXK 2015-.

1.2 Experimental drugs and reagents

The medicine bag is used for making tea, and is developed by the research center of health care and health care of functional food therapy of the university of traditional Chinese medicine in Henan; compound diphenoxylate tablet (each tablet containing diphenoxylate hydrochloride 2.5mg), yozhou kang pu pharmaceutical limited, batch number: 1805008, respectively; fructus cannabis pills (intestine moistening and bowel relaxing, constipation caused by intestinal heat and fluid deficiency, habitual constipation, oral administration, 9g once, 1-2 times a day, 60 g/bottle), Nanjing Tongrentang pharmaceutical industry Limited responsibility company, batch number: 171006.

1.3 Experimental instruments

Electronic balance (AX324ZH), ohauss instruments (chang) ltd; a measuring scale, Yiwu small fish culture product Co.

1.4 statistical methods

The data are processed by SPSS 21.0 statistical software in mean plus or minus standard deviation

The comparisons between groups were performed using one-way anova, with the passage of checks using the LSD method and the passage of checks using the Dunnett's T3 method. P < 0.05 or P < 0.01 is statistically significant.

2 method of experiment

Taking 72 healthy male KM mice, randomly dividing into a blank group, a model group, an edestan pill group and a traditional Chinese medicine teabag large, medium and small dose group, wherein each group comprises 12 mice. Except for the blank group, each group was administered with aqueous solution of compound diphenoxylate (50mg/kg) for gavage 1 time a day for 3 consecutive days. After the successful model building is determined (the blank group of mice has good mental state, sensitive reaction, glossy hair color and soft granular excrement, the model group of mice is listened and has slow reaction, dark and dull hair color and hard granular excrement, and compared with the blank group of mice, the excrement is dry and hard, small in granules and small in excrement amount, and is in a bead string shape or dry powder shape), the intragastric administration treatment is started. Pure water (0.1mL/10g) is fed into the blank group and the model group for intragastric administration, a edestan pill water solution (4.5g/kg) is fed into the edestan pill group for intragastric administration, and the medicinal bag of the invention is brewed into large (9g/kg), medium (4.5g/kg) and small (2.25g/kg) dose groups for intragastric administration at corresponding concentrations respectively.

2.1 defecation test (measurement of defecation time, stool particle count and stool weight)

The animals were fasted for 12 hours before the experiment and given 10% ink carbon indicator 0.2mL/10g 30min after the 3 rd day dosing. The animals in each group were placed in mouse cages again, placed individually, drunk water and eaten normally, and the time of first defecation, the number of black stools in 6 hours and the total weight of black stools were recorded for each mouse.

2.2 Small bowel movement experiment

The animals in each group are administered with 0.2mL/10g of 10% ink carbon-powder indicator 30min after the last administration after fasting for 12 hours before the last administration, the animals are killed by cervical dislocation after 25min, the mesentery is separated by laparotomy, the intestinal canal from the upper end to the pylorus and from the lower end to the ileocecal part is cut, the small intestine is carefully paved and stretched to be vertical to the horizontal plane, and the total length of the small intestine and the advancing length of the ink carbon-powder indicator are measured from the pylorus to the ileocecal part of the small intestine and recorded. Small bowel movements were expressed as ink propulsion rates.

The ink propulsion rate (%) is ink propulsion length (cm)/total small intestine length (cm) × 100%

3 results

3.1 Effect of Chinese medicinal teabag on defecation of Constipation model mice

TABLE 1 defecation status of mice in each group

n＝12)

Note: in comparison to the blank set,¹⁾P＜0.05，²⁾p is less than 0.01; in comparison to the model set,³⁾P＜0.05，⁴⁾P＜0.01

as can be seen from Table 1: compared with the blank group, the model group has the advantages that the time for the first black stool is obviously prolonged (P is less than 0.05), the number of black stool particles is obviously reduced within 6 hours (P is less than 0.05), and the weight of the black stool is obviously reduced (P is less than 0.01), which indicates that the molding is successful. Compared with the model group, the time of first black feces of the hemp seed pill group and the bagged tea large dose group is obviously shortened (P is less than 0.01), the number of black feces grains is obviously increased within 6 hours (P is less than 0.01), and the weight of the black feces is obviously increased (P is less than 0.01); the first time of the dosage group in the tea bag is obviously shortened (P is less than 0.05), the number of the black excrement particles in 6 hours is obviously increased (P is less than 0.05), and the weight of the black excrement is obviously increased (P is less than 0.05); the first time of the small-dose group of the tea bag obviously shortens the time of the black feces (P is less than 0.05), and the number of the black feces grains in 6 hours is obviously increased (P is less than 0.05).

3.2 Effect of bagged Chinese medicinal tea on Constipation model mouse intestinal motility

TABLE 2 intestinal motility of mice in each group: (

n＝12)

Note: in comparison with the blank set, the results,¹⁾p is less than 0.01; in comparison with the set of models,²⁾P＜0.05，³⁾P＜0.01

as can be seen from Table 2: compared with the blank group, the small intestine propulsion rate of the model group is obviously reduced (P is less than 0.01), which indicates that the model is successfully made. Compared with the model group, the small intestine propulsion rates of the large, medium and small dose groups of the hemp seed pill group and the traditional Chinese medicine bag tea are obviously or obviously increased (P is less than 0.05 or P is less than 0.01), which indicates that the small intestine peristalsis of the constipation model mouse can be obviously or obviously promoted by the large, medium and small doses of the hemp seed pill group and the traditional Chinese medicine bag tea.

4 small knot

In the experiment, a mouse constipation model is copied by the compound diphenoxylate tablet, the operation is simple and effective, and the method is a method which is used more in the current constipation research. The experimental result shows that the first time of the black stool of the mouse in the model group is prolonged, the number of black stool particles is reduced within 6h, the weight of the black stool is reduced, the small intestine propulsion rate is reduced, and the success of the model is proved; the traditional Chinese medicine tea bag can obviously or obviously shorten the first time of black stool of a constipation model mouse, increase the number of black stool particles within 6 hours, increase the weight of the black stool, obviously or obviously increase the small intestine propulsion rate and has better curative effect.

II, clinical trial data:

on the basis of ensuring the safety of animal experiments and clinical trials, the method obtains good effect, and the related data are as follows:

1 general data:

60 outpatient constipation patients who are confirmed are randomly divided into the invention and a control group, and 30 patients are respectively treated. The invention is suitable for 21 men and 9 women, and the age is 22-76 years. The control group comprises 20 men and 10 women, and the age is 21-78 years. The two groups have comparability, and the comparison difference in the aspects of sex, age, culture level and the like has no statistical significance.

2 diagnostic criteria:

eliminating constipation caused by organic diseases, medicines and other diseases, wherein the constipation symptom is more than or equal to 6 months, and the following criteria are met, namely, at least two conditions in nearly 3 months meet the following conditions that (1) the defecation is not smooth in at least 25% of the time; (2) the sense of anus blockage is felt at least 25% of the time; (3) the sense of incomplete defecation after defecation is sensed at least 25% of the time; (4) at least 25% of the time is defecation, auxiliary defecation is needed; (5) at least 25% of the time the stool dries out; (6) the patient can defecate by himself less than 3 times per week.

3, a treatment method comprises the following steps:

the invention adopts the traditional Chinese medicine tea bag for treatment, 3 g/bag, 1-2 bags/time and 3 times/day, simultaneously orders a patient to change the living and eating habits, drinks 1.5-2.0L of basic water needed by a human body every day, takes more cellulose-rich dishes for eating, carries out proper activities, harmonizes the emotion, establishes good defecation habits and the like. The control group only receives general treatment, namely non-drug treatment, changes the living and eating habits, increases the water intake, mostly eats cellulose-rich dishes, smoothes the emotion, establishes good defecation habits and the like. 7d is a course of treatment, and the curative effect is evaluated in one course of treatment.

4, evaluating the curative effect:

the effect is obvious, the constipation symptom of the patient disappears, and the defecation condition is recovered to be normal; effectively, the constipation symptom of the patient is obviously improved, and the defecation condition is close to normal; the constipation symptom of the patient does not obviously change and even has the tendency of aggravation.

5, statistical treatment:

after treatment according to the treatment scheme, the statistical treatment results show that 30 cases of the group have 17 cases of obvious effect, 10 cases of effect and 3 cases of no effect, and the total effective rate is 90%. The control group comprises 30 cases, 5 cases with obvious effect, 9 cases with effect and 16 cases with no effect, and the total effective rate is 46.6 percent. The effective rate of the invention is obviously higher than that of a control group, no adverse reaction is found during the medication period, and no toxic or side effect is caused. The patients with the disease have no recurrence after one week of follow-up visit, which shows safe medication and good curative effect.

Conclusion 6:

the tests show that the invention has the advantages of rich raw materials, simple preparation method, easy production and preparation, convenient taking, obvious function of relaxing the bowels, safe medication, definite curative effect, no toxic or side effect, good use value, easy acceptance, convenient popularization and application, development of a new way of treating the constipation medicine, innovation of the medicine for treating the constipation and obvious economic and social benefits.

Claims

1. A traditional Chinese medicine teabag for treating constipation is characterized by being prepared from the following raw materials in parts by weight: 13-17g of fried cassia seed, 13-17g of fried radish seed, 13-17g of sophora flower, 10-14g of mulberry, 1-5g of fried lotus plumule, 10-14g of fennel, 10-14g of dried orange peel, 10-14g of peach blossom, 10-14g of dandelion and 10-14g of fried bunge cherry seed, and the fried cassia seed, the fried radish seed, the sophora flower, the mulberry, the fried lotus plumule, the fennel, the dried orange peel, the peach blossom, the dandelion and the fried bunge cherry seed are crushed into 5-10-mesh coarse powder, mixed evenly and packaged into bags.

2. The traditional Chinese medicine teabag for treating constipation according to claim 1, which is prepared from the following raw materials by weight: 15g of fried cassia seed, 15g of fried radish seed, 15g of sophora flower, 12g of mulberry, 3g of fried lotus plumule, 12g of fennel, 12g of dried orange peel, 12g of peach blossom, 12g of dandelion and 12g of fried bunge cherry seed, and the fried cassia seed, the fried radish seed, the sophora flower, the mulberry, the fried lotus plumule, the fennel, the dried orange peel, the peach blossom, the dandelion and the fried bunge cherry seed are crushed into coarse powder which is sieved by a 5-10 mesh sieve, mixed evenly and subpackaged into bags to obtain the Chinese patent medicine.

3. The traditional Chinese medicine teabag for treating constipation according to claim 1, which is prepared from the following raw materials by weight: 14g of fried cassia seed, 16g of fried radish seed, 14g of sophora flower, 13g of mulberry, 2g of fried lotus plumule, 13g of fennel, 11g of dried orange peel, 13g of peach blossom, 11g of dandelion and 13g of fried bunge cherry seed, and the fried cassia seed, the fried radish seed, the sophora flower, the mulberry, the fried lotus plumule, the fennel, the dried orange peel, the peach blossom, the dandelion and the fried bunge cherry seed are crushed into coarse powder which is sieved by a 5-10-mesh sieve, mixed evenly and subpackaged into bags to obtain the Chinese patent medicine.

4. The traditional Chinese medicine teabag for treating constipation according to claim 1, which is prepared from the following raw materials by weight: the Chinese medicine is prepared by crushing 16g of fried cassia seed, 14g of fried radish seed, 16g of sophora flower, 11g of mulberry, 4g of fried lotus plumule, 11g of fennel, 13g of dried orange peel, 11g of peach blossom, 13g of dandelion and 11g of fried bunge cherry seed into coarse powder which is sieved by a 5-10 mesh sieve, uniformly mixing, and subpackaging into bags.