CN110812405A - Citrus aurantium flower essential oil for treating functional constipation - Google Patents
Citrus aurantium flower essential oil for treating functional constipation Download PDFInfo
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- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
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Abstract
The invention relates to a poncirus trifoliata essential oil for treating functional constipation, which can effectively solve the problem of medicament application for treating the functional constipation and adopts the technical scheme that the poncirus trifoliata essential oil comprises the following components: dissolving and uniformly mixing 5-7mL of rhubarb essential oil, 4-6mL of fructus forsythiae essential oil, 5-7mL of pharbitis seed essential oil, 5-7mL of immature bitter orange essential oil, 5-7mL of combined spicebush root essential oil, 4-6mL of rose essential oil and 5-7g of menthol; the traditional Chinese medicine composition has the advantages of rich raw materials, simple preparation method, easy production and preparation, convenient use and good effect, has the function of improving constipation, is an innovation on medicines for treating functional constipation, and has remarkable economic and social benefits.
Description
Technical Field
The invention relates to a medicine, in particular to a poncirus trifoliata flower essential oil for treating functional constipation.
Background
Constipation is a common clinical symptom, manifested by dry stools, difficulty in defecation, and reduction in stool weight and frequency. With the aging of society, the change of modern life rhythm and eating habits, the change of disease spectrum and other influences on diseases, constipation becomes one of important factors influencing the life quality of modern people and is closely related to the onset of colorectal cancer. Constipation is caused by various causes such as neurogenic and systemic diseases, and is called secondary constipation. For example, constipation does not have an organic lesion causing constipation, which is called functional constipation, and it has been considered that simple constipation, habitual constipation, idiopathic constipation, and the like. The use of purgative bowel disease and colonic melanosis in constipation sufferers has attracted considerable attention because colonic melanosis is associated with colon cancer and the treatment of functional constipation is therefore becoming more and more important.
Disclosure of Invention
In view of the above situation, in order to overcome the defects of the prior art, the invention aims to provide the poncirus trifoliata essential oil for treating functional constipation, which can effectively solve the problem of treatment medication for treating functional constipation.
The technical scheme of the invention is that the poncirus trifoliata essential oil for treating functional constipation comprises the following components: dissolving and uniformly mixing 5-7mL of rhubarb essential oil, 4-6mL of fructus forsythiae essential oil, 5-7mL of pharbitis seed essential oil, 5-7mL of immature bitter orange essential oil, 5-7mL of combined spicebush root essential oil, 4-6mL of rose essential oil and 5-7g of menthol; wherein:
the rhubarb essential oil is prepared by crushing rhubarb into coarse powder which is sieved by a sieve of 10-20 meshes and supercritical CO2Extracting a fluid, wherein the weight-volume ratio of liquid to material is 1: 10-20, the weight-volume ratio refers to that the solid is measured by g, the liquid is measured by mL (the same below), the extraction temperature is 42-50 ℃, the extraction pressure is 20-25 MPa, the separation temperature is 50-60 ℃, the separation pressure is 4.5-5.5 MPa, and the extraction time is 1.5-2.5 h, so that the rhubarb essential oil is obtained;
the fructus forsythiae essential oil is prepared by crushing fructus forsythiae into coarse powder which is sieved by a sieve of 10-20 meshes and supercritical CO2Fluid extraction is carried out, wherein the weight-volume ratio of liquid to material is 1: 10-20, the extraction temperature is 42-50 ℃, the extraction pressure is 20-25 MPa, the separation temperature is 50-60 ℃, the separation pressure is 4.5-5.5 MPa, and the extraction time is 1.5-2.5 h, so that the forsythia essential oil is obtained;
the pharbitis seed essential oil is prepared by crushing pharbitis seeds into coarse powder which is sieved by a sieve of 10-20 meshes and supercritical CO2Fluid extraction is carried out, wherein the weight-volume ratio of liquid to material is 1: 10-20, the extraction temperature is 42-50 ℃, the extraction pressure is 20-25 MPa, the separation temperature is 50-60 ℃, the separation pressure is 4.5-5.5 MPa, and the extraction time is 1.5-2.5 h, so that the pharbitis seed essential oil is obtained;
the immature bitter orange essential oil is prepared by crushing immature bitter oranges into coarse powder which is sieved by a sieve of 10-20 meshes and performing supercritical treatmentCO2Performing fluid extraction, wherein the weight-volume ratio of liquid to material is 1: 10-20, the extraction temperature is 42-50 ℃, the extraction pressure is 20-25 MPa, the separation temperature is 50-60 ℃, the separation pressure is 4.5-5.5 MPa, and the extraction time is 1.5-2.5 h, so as to obtain the immature bitter orange essential oil;
the lindera aggregata essential oil is prepared by crushing lindera aggregata into coarse powder which is sieved by a sieve of 10-20 meshes and supercritical CO2Extracting with a fluid, wherein the weight-volume ratio of liquid to material is 1: 10-20, the extraction temperature is 42-50 ℃, the extraction pressure is 20-25 MPa, the separation temperature is 50-60 ℃, the separation pressure is 4.5-5.5 MPa, and the extraction time is 1.5-2.5 h, so as to obtain lindera aggregata essential oil;
the rose essential oil is prepared by crushing rose into coarse powder which is sieved by a sieve of 10-20 meshes and supercritical CO2Extracting with a fluid, wherein the weight-volume ratio of liquid to material is 1: 10-20, the extraction temperature is 42-50 ℃, the extraction pressure is 20-25 MPa, the separation temperature is 50-60 ℃, the separation pressure is 4.5-5.5 MPa, and the extraction time is 1.5-2.5 h, so as to obtain the rose essential oil;
the mentholum is the mentholum which meets the standards of Chinese pharmacopoeia.
In the formula, the rhubarb, which is bitter and cold in property, releases heat, attacks accumulation and relieves constipation, and washes away heat accumulation and stagnation of the stomach and intestine; qian niu Zi is bitter and cold in property and purges water and relaxes bowels, and both are used as monarch drugs. The bitter and pungent bitter and slightly cold immature bitter orange is taken as a ministerial drug, and the effects of relieving qi stagnation, opening stuffiness and dispersing stagnation are achieved, so that the effect of the rhubarb on relieving stagnation is assisted, and the qi stagnation, the abdominal pain and the stuffiness are relieved. The combined spicebush root has the effects of promoting qi circulation and relieving pain, the rose has the effects of promoting qi circulation and relieving depression and pain, and the weeping forsythia has the effect of clearing heat to help purgation; the menthol ice has pungent, strong and fragrant taste, no obstruction, no slight obstruction and enhanced efficacy. The whole formula has the effects of purging and promoting qi circulation, and purgation is favorable for promoting qi circulation and qi circulation is helpful for purgation.
The traditional Chinese medicine composition has the advantages of rich raw materials, simple preparation method, easy production and preparation, convenient use and good effect, has the function of improving constipation, is an innovation on medicines for treating functional constipation, and has remarkable economic and social benefits.
Detailed Description
The following examples are provided to explain the present invention in detail.
The invention may be embodied in the form of the following examples.
Example 1
In the specific implementation of the invention, the poncirus trifoliata essential oil for treating functional constipation comprises the following components: 6mL of rhubarb essential oil, 5mL of forsythia essential oil, 6mL of pharbitis seed essential oil, 6mL of immature bitter orange essential oil, 6mL of combined spicebush root essential oil, 5mL of rose essential oil and 6g of menthol, and dissolving and uniformly mixing the components to prepare the traditional Chinese medicine composition; wherein:
the rhubarb essential oil is prepared by crushing rhubarb into coarse powder which is sieved by a sieve of 10-20 meshes and supercritical CO2Extracting a fluid, wherein the weight-volume ratio of liquid to material is 1: 10-20, the weight-volume ratio refers to that the solid is measured by g, the liquid is measured by mL (the same below), the extraction temperature is 42-50 ℃, the extraction pressure is 20-25 MPa, the separation temperature is 50-60 ℃, the separation pressure is 4.5-5.5 MPa, and the extraction time is 1.5-2.5 h, so that the rhubarb essential oil is obtained;
the fructus forsythiae essential oil is prepared by crushing fructus forsythiae into coarse powder which is sieved by a sieve of 10-20 meshes and supercritical CO2Fluid extraction is carried out, wherein the weight-volume ratio of liquid to material is 1: 10-20, the extraction temperature is 42-50 ℃, the extraction pressure is 20-25 MPa, the separation temperature is 50-60 ℃, the separation pressure is 4.5-5.5 MPa, and the extraction time is 1.5-2.5 h, so that the forsythia essential oil is obtained;
the pharbitis seed essential oil is prepared by crushing pharbitis seeds into coarse powder which is sieved by a sieve of 10-20 meshes and supercritical CO2Fluid extraction is carried out, wherein the weight-volume ratio of liquid to material is 1: 10-20, the extraction temperature is 42-50 ℃, the extraction pressure is 20-25 MPa, the separation temperature is 50-60 ℃, the separation pressure is 4.5-5.5 MPa, and the extraction time is 1.5-2.5 h, so that the pharbitis seed essential oil is obtained;
the immature bitter orange essential oil is prepared by crushing immature bitter oranges into coarse powder which is sieved by a sieve of 10-20 meshes and supercritical CO2Performing fluid extraction, wherein the weight-volume ratio of liquid to material is 1: 10-20, the extraction temperature is 42-50 ℃, the extraction pressure is 20-25 MPa, the separation temperature is 50-60 ℃, the separation pressure is 4.5-5.5 MPa, and the extraction time is 1.5-2.5 h, so as to obtain the immature bitter orange essential oil;
the lindera aggregata essential oil is prepared by crushing lindera aggregata into coarse powder which is sieved by a sieve of 10-20 meshes and supercritical CO2Extracting with a fluid, wherein the weight-volume ratio of liquid to material is 1: 10-20, the extraction temperature is 42-50 ℃, the extraction pressure is 20-25 MPa, the separation temperature is 50-60 ℃, the separation pressure is 4.5-5.5 MPa, and the extraction time is 1.5-2.5 h, so as to obtain lindera aggregata essential oil;
the rose essential oil is prepared by crushing rose into coarse powder which is sieved by a sieve of 10-20 meshes and supercritical CO2Extracting with a fluid, wherein the weight-volume ratio of liquid to material is 1: 10-20, the extraction temperature is 42-50 ℃, the extraction pressure is 20-25 MPa, the separation temperature is 50-60 ℃, the separation pressure is 4.5-5.5 MPa, and the extraction time is 1.5-2.5 h, so as to obtain the rose essential oil;
the mentholum is the mentholum which meets the standards of Chinese pharmacopoeia.
Example 2
In the specific implementation of the invention, the poncirus trifoliata essential oil for treating functional constipation comprises the following components: 5.5mL of rhubarb essential oil, 5.5mL of weeping forsythia essential oil, 5.5mL of pharbitis seed essential oil, 6.5mL of immature bitter orange essential oil, 5.5mL of combined spicebush root essential oil, 5.5mL of rose essential oil and 6.5g of menthol are dissolved and uniformly mixed to prepare the traditional Chinese medicine composition, and the preparation method is the same as that of example 1.
Example 3
In the specific implementation of the invention, the poncirus trifoliata essential oil for treating functional constipation comprises the following components: 6.5mL of rhubarb essential oil, 4.5mL of weeping forsythia essential oil, 6.5mL of pharbitis seed essential oil, 5.5mL of immature bitter orange essential oil, 6.5mL of combined spicebush root essential oil, 4.5mL of rose essential oil and 5.5g of menthol are dissolved and uniformly mixed to prepare the traditional Chinese medicine composition, and the preparation method is the same as that of example 1.
The invention has scientific and reasonable compatibility, mutually supports the components, has the effect of improving constipation, is effectively used for treating functional constipation, has very good experimental effect, and has the following relevant data:
firstly, animal experiments:
1 materials of the experiment
1.1 Experimental animals
Kunming mice, SPF level, male, weight 18-20 g, 156, license number: SCXK (lu) 20140007, quality certification for experimental animals: no.37009200018686, supplied by Experimental animals centre, Shandong province. And (5) feeding in cages. Laboratory license number: SYXK 2015-.
1.2 Experimental reagents and drugs
The product of the embodiment 1 of the invention; positive drugs: fructus Cannabis pill, Nanjing Tongrentang pharmaceutical industry, Inc., batch No. 171006, Compound diphenoxylate tablet (national Standard H320223716, batch No. 1708019, Changzhou Kangpu pharmaceutical industry, Inc., each tablet contains diphenoxylate hydrochloride 2.5mg and atropine sulfate 25 (μ g), Compound diphenoxylate, national Standard H320716, batch No. 1708019, and Changzhou Kangpu pharmaceutical industry, Inc. (preparation: taking 50mg (20 tablets) of Compound diphenoxylate tablet, grinding into powder with mortar, adding water to 100mL, the concentration is 0.5mg/mL, and preparing before use).
Carbon powder: 100g of Arabic gum is added with 800mL of water, the mixture is boiled until the solution is transparent, 50g of active carbon (powder) is weighed and added into the solution to be boiled for 3 times, and after the solution is cooled, water is added to the solution to reach the constant volume of 1000 mL.
Experimental methods
2.1 Effect on dryness losing Water loss Constipation model in mice
(1) Influence on small intestine peristalsis of dryness-node water loss mouse constipation model
60 healthy KM mice with SPF level and male quality of 18-22 g are taken, and the test is started after adaptive feeding for 3 days. And from the 4 th day, randomly selecting 12 mice as blank groups, feeding rice to another mouse, keeping water (including all water in vegetables) for 3 days continuously, and making a model of drying, losing water and constipation. Selecting 48 constipation model mice with yellow urine, dry and beaded feces, and successful molding, and randomly dividing into model group and large dosage group (abdomen depilation coated with fructus Aurantii Immaturus essential oil 0.15 ml/cm)2Coating 0.15ml/cm of semen Hoveniae essential oil at an interval of 10min2) And small dose of Huangzhihua essential oil (abdomen depilating, applying Huangzhihua essential oil 0.15ml/cm on abdomen)2) And edestan pill group (4.5 g/kg,0.15g/ml,0.3ml/10 g). 30min after the last administration, each group of mice was given 10% (20 ml/kg) of carbon powder suspension, 20min later, the mice were sacrificed by dislocation of cervical vertebrae, the abdominal cavity was cut open to separate mesentery, the cardia of the mice was cut to the pyloric full stomach, and the mice were spread on a glass plate to measure the total length of the small intestine and the push length of carbon powder, respectively. Cutting the intestinal canal from the pylorus to the ileocecal part, slightly drawing the intestinal canal into a straight line, measuring the length of the intestinal canal as the total length of the small intestine, measuring the advancing length of the carbon powder from the pylorus to the front edge of the carbon powder, and calculating the advancing rate of the carbon powder, wherein the advancing rate (%) of the carbon powder is equal to the advancing distance of the carbon powder/the length of the small intestine multiplied by 100%. The results are shown in Table 1.
(2) Influence on constipation model of mice with desiccation and dehydration on large intestine peristalsis
60 healthy KM mice with SPF level and male quality of 18-22 g are taken, and the test is started after adaptive feeding for 3 days. And from the 4 th day, randomly selecting 12 mice as blank groups, feeding rice to another mouse, keeping water (including all water in vegetables) for 3 days continuously, and making a model of drying, losing water and constipation. Selecting 48 constipation model mice with yellow urine, dry and beaded feces, and successful molding, and randomly dividing into model group and large dosage group (abdomen depilation coated with fructus Aurantii Immaturus essential oil 0.15 ml/cm)2Coating 0.15ml/cm of semen Hoveniae essential oil at an interval of 10min2) And small dose of Huangzhihua essential oil (abdomen depilating, applying Huangzhihua essential oil 0.15ml/cm on abdomen)2) And edestan pill group (4.5 g/kg,0.15g/ml,0.3ml/10 g). 30min after the last application, all groups were drenched with 10% (0.2 mL/10 g) carbon powder suspension. Starting from the carbon powder suspension, the time of appearance of the first black stool, the number of black stools within 6 hours and the total weight were recorded. The results are shown in Table 2.
2.2 Effect on Compound diphenoxylate-induced Constipation model in mice
(1) Influence on small intestine peristalsis of compound diphenoxylate-induced mouse constipation model
60 healthy KM mice with SPF level and male quality of 18-22 g are taken, and the test is started after adaptive feeding for 3 days. From day 4, randomly selecting 12 mice as blank groups, randomly dividing the mice into model groups, large and small dose groups of the citrus aurantium essential oil and hemp seed pill groups, filling 10mg/kg of compound diphenoxylate tablets into the rest 3 groups except the blank groups, and causing a constipation model after 30 min. Respectively administering large dose of HUANGZHIHUA essential oil (abdomen depilating, applying HUANGZHIHUA essential oil 0.15 ml/cm)2Coating 0.15ml/cm of semen Hoveniae essential oil at an interval of 10min2) And small dose of Huangzhihua essential oil (abdomen depilating, applying Huangzhihua essential oil 0.15ml/cm on abdomen)2) And a edestan pill group (4.5 g/kg,0.15g/ml,0.3ml/10 g). 30min after the last administration, each group of mice is administered with 10% (20 ml/kg) carbon powder suspension, 20min later, the mice are killed by dislocation of cervical vertebra, abdominal cavity is cut open, mesentery is separated, cardia of the mice is cut to pyloric holostomach, and the mice are laid on a glass plate for distributionThe total length of the small intestine and the length of carbon dust propulsion were measured separately. Cutting the intestinal canal from the pylorus to the ileocecal part, slightly drawing the intestinal canal into a straight line, measuring the length of the intestinal canal as the total length of the small intestine, measuring the advancing length of the carbon powder from the pylorus to the front edge of the carbon powder, and calculating the advancing rate of the carbon powder, wherein the advancing rate (%) of the carbon powder is equal to the advancing distance of the carbon powder/the length of the small intestine multiplied by 100%. The results are shown in Table 3.
(2) Influence on compound diphenoxylate-induced constipation model mouse large intestine peristalsis
60 healthy KM mice with SPF level and male quality of 18-22 g are taken, and the test is started after adaptive feeding for 3 days. From day 4, randomly selecting 12 mice as blank groups, randomly dividing the mice into model groups, large and small dose groups of the citrus aurantium essential oil and hemp seed pill groups, filling 10mg/kg of compound diphenoxylate tablets into the rest 3 groups except the blank groups, and causing a constipation model after 30 min. Respectively administering large dose of HUANGZHIHUA essential oil (abdomen depilating, applying HUANGZHIHUA essential oil 0.15 mL/cm)2Coating 0.15ml/cm of semen Hoveniae essential oil at an interval of 10min2) And small dose of Huangzhihua essential oil (abdomen depilating, applying Huangzhihua essential oil 0.15ml/cm on abdomen)2) And a edestan pill group (4.5 g/kg,0.15g/ml,0.3ml/10 g). 30min after the last application, all groups were drenched with 10% (0.2 mL/10 g) carbon powder suspension, and from the moment of drenching the carbon powder suspension, the time when the first black stool appeared, the number of black stools within 6 hours and the total weight were recorded. The results are shown in Table 4.
3 results of the experiment
3.1 Effect on dryness losing Water loss Constipation model in mice
Table 1: influence of Huangzhihua essential oil on small intestine peristalsis of dryness-knot water loss mouse constipation model (
±s)
| Group of | Animal number (only) | Carbon powder push length (cm) | Carbon powder advancing Rate (%) |
| Blank group | 12 | 41.63±7.67 | 89.85±7.93 |
| Model set | 12 | 22.67±14.52## | 46.75±29.5## |
| Fructus cannabis pill group | 12 | 33.63±6.28** | 68.96±14.51** |
| Large-dose group of Huangzhi flower essential oil | 12 | 29.96±4.37* | 63.53±8.64** |
| Small-dose group of Huangzhihua essential oil | 12 | 31.59±4.48** | 66.57±8.72** |
##In comparison to the blank set,P<0.01；#in comparison to the blank set,P<0.05; ratio to model groupP<0.05; ratio of to model groupP<0.01
From the above table, it can be seen that: both the model group toner advance length and the toner advance rate were significantly reduced compared to the blank group (P < 0.01). Compared with the model group, the small-dose group of the Huangzhi flower essential oil and the edestan pill group can obviously prolong the propelling length of the carbon powder of the mouse (P is less than 0.01), and the large-dose group of the Huangzhi flower essential oil can obviously prolong the propelling length of the carbon powder of the mouse (P is less than 0.01); the large and small dose of the Huangzhihua essential oil and the hemp seed pill can obviously increase the carbon powder propelling rate of mice (P is less than 0.01).
Table 2: influence of Huangzhihua essential oil on constipation model of mice with dryness and water loss due to large intestine peristalsis (
±s)
| Group of | Animal number (only) | First time black stool time (min) | Number of black excrement | Weight of black excrement (mg) |
| Blank group | 12 | 30.33±10.49 | 10.75±2.83 | 227.35±67.66 |
| Model set | 12 | 238.67±99.23## | 2.42±1.56## | 29.28±26.83## |
| Fructus cannabis pill group | 12 | 109.25±20.05** | 6.67±1.72** | 84.73±37.76** |
| Large-dose group of Huangzhi flower essential oil | 12 | 157.5±39.36** | 3.42±1.51 | 70.03±20.82** |
| Small-dose group of Huangzhihua essential oil | 12 | 133.08±38.6** | 5.17±2.08** | 54.52±21.51 |
##In comparison to the blank set,P<0.01；#in comparison to the blank set,P<0.05; ratio to model groupP<0.05; ratio of to model groupP<0.01
As can be seen from table 2 above, the time for the first grain to defecate was significantly prolonged (P <0.01), and the number of the grains and the stool quality were significantly reduced (P <0.01) in the model group, as compared to the blank group. Compared with the model group, the Huangzhi flower essential oil group and the fructus cannabis pill group have the advantages that the first grain defecation time is obviously shortened (P is less than 0.01); the small dosage group of the Huangzhihua essential oil and the hemp seed pill group can obviously increase the number of black feces (P is less than 0.01); the large dose group of the Huangzhi flower essential oil and the hemp seed pill group can obviously increase the weight of black feces (P is less than 0.01).
3.2 Effect on Compound diphenoxylate-induced Constipation model mice
Table 3: influence of Huangzhihua essential oil on small intestine peristalsis function of compound diphenoxylate-induced constipation model mouse (
±s)
| Group of | Animal number (only) | Carbon powder push length (cm) | Carbon powder advancing Rate (%) |
| Blank group | 12 | 43.4±6.69 | 87.66±10.3 |
| Model set | 12 | 22.88±13.41## | 45.67±27.51## |
| Fructus cannabis pill group | 12 | 33.29±6.71** | 70.19±9.38** |
| Large-dose group of Huangzhi flower essential oil | 12 | 31.83±6.44** | 60.46±11.89* |
| Small-dose group of Huangzhihua essential oil | 12 | 32.65±7.86** | 62.76±15.72** |
##In comparison to the blank set,P<0.01；#in comparison to the blank set,P<0.05; ratio to model groupP<0.05; ratio of to model groupP<0.01
As can be seen from the above table, both the toner advance length and the toner advance rate of the model set are significantly reduced (P <0.01) compared to the blank set. Compared with the model group, the large and small dose group of the Huangzhihua essential oil and the hemp seed pill group can obviously prolong the carbon powder propelling length of mice (P is less than 0.01); the small dose group of the Huangzhi flower essential oil and the fructus cannabis pill group can obviously increase the carbon powder propulsion rate of a mouse (P is less than 0.01), and the large dose group of the Huangzhi flower essential oil can obviously increase the carbon powder propulsion rate of the mouse (P is less than 0.05).
TABLE 4 influence of essential oil of trifoliate orange flower on compound diphenoxylate-induced constipation model mouse large intestine peristalsis (
±s)
| Group of | Animal number (only) | First time black stool time (min) | Number of black feces | Weight of black excrement (mg) |
| Blank group | 12 | 36.25±16.85 | 21.67±4.42 | 237.5±65.03 |
| Model set | 12 | 259±116.95## | 3±3.49## | 46.58±56.88## |
| Fructus cannabis pill group | 12 | 142.58±48.05** | 10.92±4.17** | 179.84±66.67** |
| Large-dose group of Huangzhi flower essential oil | 12 | 192.83±56.87** | 7.58±2.11** | 197.18±39.25** |
| Small-dose group of Huangzhihua essential oil | 12 | 97.33±27.38** | 11.83±5.34** | 202.43±78.87** |
##In comparison to the blank set,P<0.01；#in comparison to the blank set,P<0.05; ratio to model groupP<0.05; ratio of to model groupP<0.01
As can be seen from the above table, the first-grain defecation time of the model group was significantly prolonged (P <0.01), the number of black grains and the stool weight were significantly reduced (P <0.01) compared to the blank group. Compared with the model group, the Huangzhi flower essential oil group and the fructus cannabis pill group have the advantages that the first grain defecation time is obviously shortened (P is less than 0.01); the large and small dose of the Huangzhihua essential oil and the hemp seed pill can obviously increase the number of black excrement particles (P is less than 0.01); the large and small dose of the Huangzhi flower essential oil and the hemp seed pill can obviously increase the weight of black stool (P is less than 0.01).
Second, clinical application
Under the condition of ensuring safety in animal experiments, clinical trials prove that the effect is very good, and the related data are as follows (taking example 1 as an example):
constipation is a common clinical symptom caused by age, dietary habits, diseases, drugs and other factors, eliminates constipation caused by organic diseases and drug factors, meets the diagnosis standard of functional constipation in the roman iii standard, and is called functional constipation.
Chronic functional constipation patients 20 patients, inclusion criteria: the patient meets the Chinese and western medicine diagnosis standard of chronic functional constipation and gets rid of outlet obstruction type constipation; no other medications were taken for 1 week; organic lesions such as colon cancer, intestinal tuberculosis and inflammatory bowel disease do not exist; without a history of mental disorders or psychosis.
Spreading the essential oil around Shenque acupoint (0.2 mL/cm)2) And 2g of sterilized absorbent cotton is additionally used, 0.5mL of cinnamomum micranthum essential oil is adsorbed, the absorbent cotton adsorbing the essential oil is placed on the Shenque acupoint, and is covered by cellophane, then covered by the absorbent cotton, and fixed by adhesive plaster. And cleared after 6 hours. Applied once daily. The medicine is used for 7 days.
The curative effect index is as follows: the effect is shown: the stool character of the patient is close to normal, the defecation interval time is within 2d, and most other symptoms disappear; the method has the following advantages: the dry and hard state of the excrement of the patient is improved, the interval time of defecation is within 4d, and other symptoms are improved; and (4) invalidation: the stool character of the patient is not changed, other symptoms are not improved, and the defecation interval time exceeds 4 d.
Statistical treatment: the clinical confirmed functional constipation patients are treated by 20 patients, 10 patients are cured (50%), 9 patients are cured (45%), 1 patient is not cured, the total effective rate is 95%, and the effect is unexpected.
The same experiment is carried out on the example 1 and the examples 2 and 3 at the same time, and the same and similar results are obtained, which shows that the product has good quality and stable and reliable curative effect, and are not listed any more.
The experiments show that the traditional Chinese medicine composition has the function of improving constipation, is effectively used for treating functional constipation, has simple preparation method, abundant raw materials, easy production and preparation and definite curative effect, is an innovation on medicines for treating functional constipation, and has obvious economic and social benefits.
Claims (4)
1. The poncirus trifoliata essential oil for treating functional constipation is characterized by comprising the following components: dissolving and uniformly mixing 5-7mL of rhubarb essential oil, 4-6mL of fructus forsythiae essential oil, 5-7mL of pharbitis seed essential oil, 5-7mL of immature bitter orange essential oil, 5-7mL of combined spicebush root essential oil, 4-6mL of rose essential oil and 5-7g of menthol; wherein:
the rhubarb essential oil is prepared by crushing rhubarb into coarse powder which is sieved by a sieve of 10-20 meshes and supercritical CO2Extracting a fluid, wherein the weight-volume ratio of liquid to material is 1: 10-20, the weight-volume ratio refers to that the solid is counted by g, the liquid is counted by mL, the extraction temperature is 42-50 ℃, the extraction pressure is 20-25 MPa, the separation temperature is 50-60 ℃, the separation pressure is 4.5-5.5 MPa, and the extraction time is 1.5-2.5 h, so that the rhubarb essential oil is obtained;
the preparation methods of fructus forsythiae essential oil, semen Pharbitidis essential oil, fructus Aurantii Immaturus essential oil, radix Linderae essential oil and flos Rosae Rugosae essential oil are the same as those of radix et rhizoma Rhei essential oil.
2. The essential oil of poncirus trifoliata for treating functional constipation according to claim 1, which is prepared from the following components: 6mL of rhubarb essential oil, 5mL of forsythia essential oil, 6mL of pharbitis seed essential oil, 6mL of immature bitter orange essential oil, 6mL of lindera root essential oil, 5mL of rose essential oil and 6g of menthol.
3. The essential oil of poncirus trifoliata for treating functional constipation according to claim 1, which is prepared from the following components: 5.5mL of rhubarb essential oil, 5.5mL of forsythia essential oil, 5.5mL of pharbitis seed essential oil, 6.5mL of immature bitter orange essential oil, 5.5mL of lindera root essential oil, 5.5mL of rose essential oil and 6.5g of menthol, and dissolving and uniformly mixing the components to prepare the traditional Chinese medicine composition.
4. The essential oil of poncirus trifoliata for treating functional constipation according to claim 1, which is prepared from the following components: 6.5mL of rhubarb essential oil, 4.5mL of forsythia essential oil, 6.5mL of pharbitis seed essential oil, 5.5mL of immature bitter orange essential oil, 6.5mL of lindera root essential oil, 4.5mL of rose essential oil and 5.5g of menthol, and dissolving and uniformly mixing the components to prepare the traditional Chinese medicine composition.
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| CN102283909A (en) * | 2011-07-28 | 2011-12-21 | 冯亚西 | Medicament for treating anorectal diseases, adiposity, hyperlipemia and acnes and application thereof |
| CN105285255A (en) * | 2015-11-20 | 2016-02-03 | 刘书元 | Intestine-moistening and beauty-keeping tea |
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