CN112843151A - Traditional Chinese medicine composition for treating constipation and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating constipation and preparation method thereof Download PDFInfo
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Abstract
The invention provides a traditional Chinese medicine composition for treating constipation, which comprises the following raw materials in parts by weight: 1-8 parts of radix polygoni multiflori preparata, 1-8 parts of mulberry, 1-8 parts of black sesame, 1-4 parts of dried orange peel, 0.5-8 parts of senna leaf, 1-4 parts of black tea, 1-6 parts of moleplant seed, 0.5-3 parts of pepperweed seed and 1-6 parts of cynomorium songaricum. In the traditional Chinese medicine composition of the invention: radix polygoni multiflori preparata, mulberry and black sesame are monarch drugs, dried orange peel is ministerial drug, senna leaf, moleplant seed, pepperweed seed and cynomorium songaricum are adjuvant drugs, and black tea is conductant drug. The compatibility of herbs brings out the best in each other. Compared with the conventional traditional Chinese medicine compound for treating constipation, the traditional Chinese medicine composition provided by the invention has stronger effects of tonifying liver and kidney, has more obvious effect of relaxing bowel, and has the effects of promoting digestion and removing food retention.
Description
The invention relates to a divisional application of an invention patent with application date of 2017, 11 and 2, application number of CN201711066088.7, and name of 'a traditional Chinese medicine composition for treating constipation and a preparation method thereof'.
Technical Field
The invention relates to the field of traditional Chinese medicines, and in particular relates to a traditional Chinese medicine composition for treating constipation and a preparation method thereof.
Background
Constipation refers to the reduction of stool frequency and/or difficult stool drying, and generally no defecation occurs for more than two days, which indicates that constipation exists. Epidemiological studies indicate that constipation is a common clinical gastrointestinal disorder. With the aging of the population, patients with senile habitual constipation are increasing, and most of patients after surgery and after childbirth consume blood due to qi deficiency with constipation. In addition, the incidence rate of constipation is higher and higher due to the fact that modern life food is finer and finer, the life pressure is higher and higher, the environmental pollution is heavier and heavier, and more chemicals are used.
At present, the drugs which are widely applied clinically and used for treating constipation mainly comprise three types: the first category is stimulant laxatives with intestinal motility stimulating effect as the main drug effect, most of which are chemically synthesized products, and have more side effects, such as 'fruit guide' which is widely used clinically, and the stimulant laxatives can sometimes cause anaphylaxis, enteritis, dermatitis and bleeding tendency, and have irritation to kidney, dependence and easily induce or aggravate constipation. The second category is osmotic laxatives which stimulate the intestinal wall with high osmotic pressure to cause the defecation reflex and local lubrication, such as "enema", which can only relieve clinical symptoms, and are injected from the anus, which is inconvenient to use and easy to form drug dependence. The third type is a traditional Chinese medicine compound preparation, although the traditional Chinese medicine is an ideal Chinese patent medicine, the dosage form is mostly ointment, pill and powder, the drinking and the storage are inconvenient, for example, the dosage of the 'edestan pill' for adult oral administration is 6-9 g each time, the dosage is large, and the swallowing is difficult.
For the treatment of constipation, the traditional Chinese medicine therapy is to "purge and treat constipation", for example, the constipation treating medicine, namely the fructus cannabis pill recorded in Shanghai treatise on Cold-induced disease, is a typical purgative agent and has the effects of moistening intestines, clearing heat, promoting qi circulation and relaxing bowels. Purgatives have good therapeutic effects on constipation, but they also deplete qi and blood.
Disclosure of Invention
In view of the above, the present invention aims to provide a traditional Chinese medicine composition for treating constipation, which can effectively treat constipation and simultaneously regulate qi and blood deficiency of the body.
In order to achieve the above object, the present invention provides the following technical solutions:
the invention provides a traditional Chinese medicine composition for treating constipation, which is prepared by carrying out water extraction on the following raw materials in parts by weight: 1-8 parts of radix polygoni multiflori preparata, 1-8 parts of mulberry, 1-8 parts of black sesame, 1-4 parts of dried orange peel, 0.5-8 parts of senna leaf, 1-4 parts of black tea, 1-6 parts of moleplant seed, 0.5-3 parts of pepperweed seed and 1-6 parts of cynomorium songaricum.
Preferably, the raw materials comprise 3-4 parts of radix polygoni multiflori preparata, 2-3 parts of mulberry, 2-4 parts of black sesame, 2-3 parts of dried orange peel, 1-2 parts of senna leaf, 2-3 parts of black tea, 2-3 parts of moleplant seed, 1-2 parts of semen lepidii and 2-3 parts of cynomorium songaricum.
Preferably, the dosage form of the traditional Chinese medicine composition is tablets, granules, capsules, effervescent agents or tea bags.
The invention provides a preparation method of the traditional Chinese medicine composition in the technical scheme, which comprises the following steps:
(1) mixing the raw materials according to a ratio, soaking the mixed raw materials in water for 15-45 min, heating and extracting at 90-100 ℃ for 0.5-2 h after soaking, and filtering a mixed solution obtained after heating to obtain a supernatant and a precipitate; repeatedly carrying out the soaking, heating extraction and filtering operations on the precipitate, and combining the supernatants obtained by each filtering to obtain an extraction solution;
(2) concentrating the extraction solution obtained in the step (1), drying and crushing to obtain the traditional Chinese medicine composition.
Preferably, the step (2) of concentrating the extract solution to have a relative density of 1.0 to 1.2 as measured thermally at 60 ℃.
Preferably, the drying in step (2) is vacuum drying, and the vacuum drying conditions are as follows: 45 to 65 ℃ and a vacuum degree of-0.09 to-0.04 MPa.
Preferably, the step (2) further comprises granulating the dry powder obtained after pulverization.
Compared with the prior art, the invention has the following advantages:
the invention provides a traditional Chinese medicine composition for treating constipation, which comprises the following raw materials in parts by weight: 1-8 parts of radix polygoni multiflori preparata, 1-8 parts of mulberry, 1-8 parts of black sesame, 1-4 parts of dried orange peel, 0.5-8 parts of senna leaf, 1-4 parts of black tea, 1-6 parts of moleplant seed, 0.5-3 parts of pepperweed seed and 1-6 parts of cynomorium songaricum. In the traditional Chinese medicine composition of the invention: the prepared fleece flower root, the mulberry and the black sesame are monarch drugs, and the prepared fleece flower root enters liver and kidney meridians, is good at tonifying liver and kidney, benefiting essence and blood, and astringing essence and qi, and is not cold, dry or greasy; mulberry fruit and black sesame have the action of nourishing yin and blood, moistening intestines and promoting the production of body fluid. The dried orange peel is a ministerial drug, can invigorate the spleen and promote the circulation of qi, is pungent and bitter in property and can purge dryness, has the characteristics of tonifying with a tonifying drug and purging with a purgative, and can promote the tonifying and bowel relaxing effects of monarch drugs. Folium sennae, semen Euphorbiae, semen Lepidii and herba Cynomorii are adjuvant drugs, and folium sennae is bitter in taste, cold in nature, sticky and smooth in texture, and can enter large intestine to purge heat accumulation, relieve constipation, promote digestion and remove food stagnation when used sparingly; qianjin seed and Ting Li Zi are pungent, cool, bitter and descending, enter bladder and large intestine channels, and can promote large and small intestines and remove indigestion; the cynomorium songaricum is sweet in taste and warm in nature; it enters liver and kidney meridians, and is also an adjuvant drug in this formula, and can help monarch drugs to tonify kidney yang, replenish essence and blood, and moisten dryness and smooth intestine. The bitter and cold medicines are used as adjuvant medicines, so that the bowel relaxing effect of the composition is improved without making a noise. The black tea is a messenger drug, belongs to the whole fermentation tea, can help gastrointestinal digestion, promote appetite, promote diuresis and eliminate edema, has the characteristics of sweet and mellow taste, and can neutralize the medicinal flavor and harmonize the medicines. The monarch drugs adopted by the invention are mainly tonifying and are supplemented with other drugs for enhancing the tonifying effect and the effect of relaxing bowel, and the compatibility brings out the best in each other. Compared with the conventional traditional Chinese medicine compound for treating constipation, the traditional Chinese medicine composition provided by the invention has stronger effects of tonifying liver and kidney, has more obvious effect of relaxing bowel, and has the effects of promoting digestion and removing food retention.
The traditional Chinese medicine composition provided by the invention is reasonably compatible, substantially eliminates the traditional treatment method of 'clearing away the secret', focuses on conditioning deficiency of qi and blood of a human body, moistening dryness and lubricating intestines, and has the characteristics of 'supplementing without attaching pathogen and damaging vital qi'. Is mainly used for treating constipation such as senile weakness, illness, postpartum, postoperative, infantile fluid deficiency and blood deficiency, and the effective rate can reach 97.5%.
The invention also provides a preparation method of the traditional Chinese medicine composition for treating constipation, which is to extract effective substances from raw materials of the traditional Chinese medicine composition. Not only can maintain the characteristics of quick absorption and quick response of the traditional Chinese medicine decoction, but also can maintain more volatile components.
In some embodiments of the present invention, after the active ingredients obtained after extraction are granulated, the dissolution rate and dissolution rate of the active ingredients are improved by more than 20% compared with those of the non-granulated traditional Chinese medicine composition.
In some specific embodiments, the traditional Chinese medicine composition for treating constipation is prepared into a tea bag, is convenient to carry, has slight fragrance, sweet and sweet taste and good mouthfeel after being brewed, and has the tea drinking enjoyment and disease treatment effects.
Detailed Description
The invention provides a traditional Chinese medicine composition for treating constipation, which is prepared from the following raw materials in parts by weight: 1-8 parts of radix polygoni multiflori preparata, 1-8 parts of mulberry, 1-8 parts of black sesame, 1-4 parts of dried orange peel, 0.5-8 parts of senna leaf, 1-4 parts of black tea, 1-6 parts of moleplant seed, 0.5-3 parts of pepperweed seed and 1-6 parts of cynomorium songaricum. Preferably, the compound is prepared from the following raw materials: 3-4 parts of radix polygoni multiflori preparata, 2-3 parts of mulberry, 2-4 parts of black sesame, 2-3 parts of dried orange peel, 1-2 parts of senna leaf, 2-3 parts of black tea, 2-3 parts of moleplant seed, 1-2 parts of pepperweed seed and 2-3 parts of cynomorium songaricum.
Radix polygoni multiflori preparata: the preparation method of the processed product of fleece-flower root is referred to the item of fleece-flower root in Chinese pharmacopoeia. Radix Polygoni Multiflori Preparata has effects of entering liver, heart and kidney meridians, and tonifying essence and blood, and is better than raw radix Polygoni Multiflori, which is more important than moistening intestine to relieve constipation. The invention adopts the radix polygoni multiflori preparata as a monarch drug, mainly invigorates qi and blood of a human body, and breaks the 'secret of treatment by purgation' of the traditional therapy.
And (3) mulberry fruit: is sweet in taste and cold in nature, enters lung, liver, kidney and large intestine channels, and has the effects of tonifying liver and kidney, promoting fluid production and lubricating intestines. The mulberry is adopted as a monarch drug, has the effects of nourishing yin and blood and relaxing bowel, is mainly used for conditioning deficiency of qi and blood, and is used for moistening dryness and lubricating intestines as an auxiliary. In the present invention, the mulberry is preferably black mulberry.
Black sesame seed: sweet in flavor and neutral in nature, it enters lung, spleen, liver and kidney meridians. The black sesame is used as a monarch drug, has the effects of nourishing yin and supplementing blood, and moistening intestines to promote fluid production, and has the effects of moistening dryness by nourishing yin and supplementing blood, and relaxing bowel while tonifying.
Dried orange peel: bitter and pungent in flavor and warm in nature, entering lung and spleen meridians, they are qi-moving herbs. The tangerine peel is pungent, bitter and capable of reducing blood pressure and can discharge energy, and the tangerine peel is taken as an adjuvant drug and used for enhancing the tonifying effect and the dryness moistening and bowel relaxing effects in monarch drugs.
Folium sennae: sweet, bitter and cold in flavor, it enters large intestine meridian. The invention uses a small amount of senna leaves, can help digestion and remove food retention, and provides the traditional Chinese medicine composition with the functions of promoting digestion and removing food retention.
Semen Euphorbiae: pungent in flavor and warm in nature, it enters liver, kidney and large intestine meridians. Semen lepidii: pungent, bitter and cold in flavor, entering lung, bladder and large intestine meridians. The Chinese medicinal composition takes the moleplant seed and the pepperweed seed as adjuvant medicaments, and can relieve large and small intestines, remove indigestion, and enhance the effects of relaxing bowel and promoting digestion and removing food retention.
Black tea: is a fully fermented tea, can regulate the drugs, regulate the taste of the traditional Chinese medicine composition, improve the compliance of patients and facilitate the taking.
And (3) locking the positive: sweet in flavor and warm in nature. It enters liver and kidney meridians. The formula is also an adjuvant drug, and can help monarch drugs to tonify kidney yang, replenish essence and blood, and moisten dryness and smooth intestines.
In the invention, the cynomorium songaricum is added for further enhancing the tonifying effect of monarch drugs and simultaneously improving the dryness moistening and intestine smoothing effects of the prescription.
The raw material sources of the traditional Chinese medicine composition in the technical scheme are not particularly limited, and the traditional Chinese medicine composition can be prepared from commercially available commodities.
In the invention, the dosage form of the traditional Chinese medicine composition is tablets, granules, capsules, effervescent agents or tea bags. The method for preparing the traditional Chinese medicine composition into various dosage forms adopts a conventional preparation mode. The traditional Chinese medicine composition provided by the invention is prepared into various preparations, is convenient to carry, has good taste, and has tea fragrance as black tea in the raw materials is used for harmonizing the taste of the traditional Chinese medicine composition.
Specifically, when the traditional Chinese medicine composition is a tea bag, the traditional Chinese medicine composition is convenient to carry and drink, has slight fragrance and sweet taste, has the effects of enjoying and treating diseases when being drunk, and avoids the problems that the conventional traditional Chinese medicine composition is poor in taste and is unwilling to take by patients.
The invention also provides a preparation method of the traditional Chinese medicine composition in the technical scheme, which comprises the following steps:
(1) mixing the raw materials according to a ratio, soaking the mixed raw materials in water for 15-45 min, heating and extracting at 90-100 ℃ for 0.5-2 h after soaking, and filtering a mixed solution obtained after heating to obtain a supernatant and a precipitate; repeatedly carrying out the soaking, heating extraction and filtering operations on the precipitate, and combining the supernatants obtained by each filtering to obtain an extraction solution;
(2) concentrating the extraction solution obtained in the step (1), drying and crushing to obtain the traditional Chinese medicine composition.
In the invention, the raw materials of the traditional Chinese medicine composition are preferably crushed and then mixed; the particle size of the crushed raw materials is preferably 20-80 meshes, and more preferably 60 meshes.
In the invention, the mass ratio of the raw material or the precipitate to water for soaking each time is 1: 6-10, and more preferably 1: 8. The soaking time is preferably 25-35 min, and more preferably 30 min. The heating time is preferably 1-1.5 h. The number of times of the repeated operation of the precipitation is preferably 1-4 times, and more preferably 2 times. The filtering operation is not particularly limited, and a conventional filtering mode is adopted.
After the extraction solution is obtained, the extraction solution is concentrated, dried and crushed to obtain the traditional Chinese medicine composition. The concentration method of the invention is preferably vacuum concentration, and more preferably vacuum concentration is carried out at 55-70 ℃. The pressure for the concentration under reduced pressure in the present invention is preferably-0.06 to-0.04 MPa, and more preferably-0.05 MPa. The relative density of the extraction solution obtained after concentration is 1.0-1.2 (60 ℃ thermal measurement).
In the present invention, the method for drying the concentrated extract solution is preferably low-temperature vacuum drying, more preferably vacuum drying at 45 to 65 ℃, and most preferably 60 ℃. The vacuum degree of the low-temperature vacuum drying is preferably-0.09 to-0.04 MPa, and more preferably-0.06 to-0.05 MPa. In the invention, the time of the low-temperature vacuum drying is preferably 2-6 h, and more preferably 3-4 h.
The invention adopts low-temperature concentration and low-temperature drying, which can reduce the loss of the extracted substances in the preparation process and prevent the loss of volatile substances in the extracted solution.
In the present invention, the pulverized particle size is preferably 10 to 50 mesh, and more preferably 18 to 20 mesh.
According to the invention, the dry powder obtained by crushing is preferably mixed with the pharmaceutic adjuvant after crushing, and the mixture is granulated to obtain the traditional Chinese medicine composition. The invention can improve the dissolution rate and dissolution rate of the medicine after granulating the dry powder, and the dissolution rate is improved by more than 20 percent compared with the dry powder which is not granulated.
In the invention, the mass ratio of the dry powder to the pharmaceutic adjuvant is preferably 4-6: 1, and more preferably 5: 1. In the present invention, the pharmaceutical excipients include, but are not limited to, wetting agents, binders, fillers, and the like.
In the present invention, the granulation method is preferably wet granulation, and a conventional wet granulation method is adopted.
In the invention, the pharmaceutical excipients are preferably ethanol solution with the mass fraction of 80-95%, starch and dextrin, wherein the mass ratio of the total mass of the starch and the dextrin to the dry powder is 0.4-1.0: 0.5-2; more preferably 0.8: 1.
In the invention, the mass ratio of the ethanol solution with the mass fraction of 80-95%, the starch and the dextrin is preferably 0.54-0.9: 0.2-0.8; most preferably 0.45-0.9: 0.3-0.4.
The traditional Chinese medicine composition provided by the invention can be prepared into various dosage forms by adopting a conventional preparation mode, and the traditional Chinese medicine composition is not particularly limited in the application.
The technical solution of the present invention will be clearly and completely described below with reference to the embodiments of the present invention. It is to be understood that the described embodiments are merely exemplary of the invention, and not restrictive of the full scope of the invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1
The traditional Chinese medicine composition for treating constipation comprises the following raw materials in parts by weight: 3 parts of radix polygoni multiflori preparata, 2 parts of mulberry, 2 parts of black sesame, 3 parts of dried orange peel, 2 parts of senna leaf, 3 parts of black tea, 4 parts of cistanche, 3 parts of cynomorium songaricum, 2 parts of moleplant seed and 1 part of pepperweed seed.
Mixing the above materials, soaking in 200 parts of water for 30min, heating at 100 deg.C for 1 hr, filtering to obtain supernatant and precipitate. Repeating the above soaking, heating and filtering operations for 1 time, and mixing the supernatants to obtain extractive solution.
Concentrating the extracting solution under reduced pressure at 60 ℃ and under the condition of-0.05 MPa until the relative density is 1.0-1.2 (measured by heat at 60 ℃), drying the extracting solution under vacuum at low temperature for 4 hours under the condition of vacuum degree of 60 ℃ and under the condition of-0.05 MPa, and crushing the dried extracting solution to 18-20 meshes to obtain dry powder.
Mixing 1 part of dry powder, 0.4 part of starch and 0.4 part of dextrin, adding 0.72 part of 90% ethanol by mass as wetting agent, uniformly mixing, sieving with a 20-mesh sieve to prepare wet granules, drying at 65 ℃, grading, and subpackaging to 3 g/bag to obtain the granules of the traditional Chinese medicine composition.
Example 2
The traditional Chinese medicine composition for treating constipation comprises the following raw materials in parts by weight: 4 parts of prepared fleece-flower root, 3 parts of mulberry, 2 parts of black sesame, 2 parts of dried orange peel, 1 part of senna leaf, 3 parts of black tea, 3 parts of moleplant seed and 1 part of pepperweed seed.
Pulverizing the above materials respectively to 60 mesh, mixing, soaking in 114 parts of water for 45min, heating at 95 deg.C for 1.5h, filtering to obtain supernatant and precipitating. Repeating the above soaking, heating and filtering operations for 2 times, and mixing the supernatants obtained by 3 times of extraction to obtain extractive solution.
Concentrating the extract under reduced pressure at 65 deg.C and-0.06 MPa to relative density of 1.0-1.2 (measured at 60 deg.C), vacuum drying at 55 deg.C and-0.05 MPa for 3 hr, drying, and pulverizing to 20 mesh to obtain dry powder. Bagging the dry powder according to the specification of 2.2-2.8 g/bag to prepare a tea bag of the traditional Chinese medicine composition.
The taking method comprises the following steps: soaking in water to obtain tea.
Example 3
The traditional Chinese medicine composition for treating constipation comprises the following raw materials in parts by weight: 8 parts of prepared fleece-flower root, 8 parts of mulberry, 4 parts of black sesame, 4 parts of dried orange peel, 8 parts of senna leaf, 4 parts of black tea, 1 part of cynomorium songaricum, 6 parts of moleplant seed and 6 parts of pepperweed seed.
Mixing the above materials, soaking in 490 parts of water for 15min, heating at 90 deg.C for 0.5h, filtering to obtain supernatant and precipitating. Repeating the above soaking, heating and filtering operations for 3 times, and mixing the supernatants to obtain extractive solution.
Concentrating the extracting solution under reduced pressure at 60 ℃ and under the condition of-0.04 MPa until the relative density is 1.0-1.2 (measured at 60 ℃), drying the extracting solution under vacuum at low temperature for 4 hours under the condition of 65 ℃ and-0.06 MPa of vacuum degree, and crushing the drying solution to 18-20 meshes to obtain dry powder. And (3) filling the dry powder into capsules according to the specification of 0.5 g/capsule to obtain the capsules of the traditional Chinese medicine composition.
The taking method comprises the following steps: taken with warm water three times a day, 3 granules each time.
Example 4
The traditional Chinese medicine composition provided by the invention is used for clinically treating 355 constipation patients, so that the clinical curative effect of the traditional Chinese medicine composition on constipation is shown.
[ general information ]
355 treatment groups, of which 132 men and 223 women; 79 cases under 30 years old, 33 cases between 31 and 40 years old, 88 cases between 41 and 88 cases between 51 and 60 years old, 53 cases between 61 and 70 years old, and 46 cases above 70 years old.
[ diagnostic standards ]
The defecation interval time exceeds the habit of the user for more than 1 day, or the defecation interval time of two times is more than 3 days.
② dry stool.
And thirdly, the defecation is strenuous, accompanied by defecation discomfort or pain or incomplete defecation feeling.
And eliminating organic constipation through physical examination, physical and chemical examination or special examination.
And any one of (iv), (iv) and (iv) can be diagnosed if the duration exceeds 2 weeks.
[ METHOD OF TREATMENT ]
The treatment group took 1 bag of the Chinese medicinal composition prepared in example 1 each time, and took the composition with water after meals. Mild patients had 1 pack per day and severe patients had 2 packs per day.
The treatment groups were administered continuously for 3 weeks.
[ therapeutic formulation and results ]
Formulation of treatment
1. Has obvious effect (defecating once on the day or the next day, no difficulty, formation of stool and basically disappearance of accompanied symptoms)
2. Effective (3 days, once defecation, no difficulty, formation of stool, accompanied symptom improvement)
3. No effect (no defecation or difficult defecation after more than 3 days, no obvious improvement of symptoms).
And (4) observing results:
355 cases of treatment group, 323 cases with clinical significant effect, account for 91.1%; 23 cases of effectiveness account for 6.4 percent; 9 cases of the traditional Chinese medicine are invalid, accounting for 2.5 percent, and the total effective rate is 97.5 percent.
Therefore, the traditional Chinese medicine composition provided by the invention has the advantages that the total effective rate of treating constipation reaches 97.5%, the obvious effective rate is 91.1%, the curative effect on constipation is obvious, the taking and carrying are convenient, and the compliance of patients is high.
The foregoing is only a preferred embodiment of the present invention, and it should be noted that, for those skilled in the art, various modifications and decorations can be made without departing from the principle of the present invention, and these modifications and decorations should also be regarded as the protection scope of the present invention.
Claims (8)
1. A traditional Chinese medicine composition for treating constipation is prepared by water extraction of the following raw materials in parts by weight: 1-8 parts of radix polygoni multiflori preparata, 1-8 parts of mulberry, 1-8 parts of black sesame, 1-4 parts of dried orange peel, 0.5-8 parts of senna leaf, 1-4 parts of black tea, 1-6 parts of moleplant seed, 0.5-3 parts of pepperweed seed and 1-6 parts of cynomorium songaricum.
2. The traditional Chinese medicine composition according to claim 1, wherein the raw materials comprise 3-4 parts of radix polygoni multiflori preparata, 2-3 parts of mulberry, 2-4 parts of black sesame, 2-3 parts of dried orange peel, 1-2 parts of senna leaf, 2-3 parts of black tea, 2-3 parts of stephania japonica, 1-2 parts of semen lepidii and 2-3 parts of cynomorium songaricum.
3. The Chinese medicinal composition according to claim 1 or 2, wherein the Chinese medicinal composition is in the form of tablet, granule, capsule, effervescent or teabag.
4. A method for preparing the Chinese medicinal composition of any one of claims 1 to 3, comprising the steps of:
(1) mixing the raw materials according to a ratio, soaking the mixed raw materials in water for 15-45 min, heating and extracting at 90-100 ℃ for 0.5-2 h after soaking, filtering a mixed solution obtained after heating and extracting to obtain a supernatant and a precipitate; repeatedly carrying out the soaking, heating extraction and filtering operations on the precipitate, and combining the supernatants obtained by each filtering to obtain an extraction solution;
(2) concentrating the extraction solution obtained in the step (1), drying and crushing to obtain the traditional Chinese medicine composition.
5. The method according to claim 4, wherein the step (2) of concentrating the extract solution to have a relative density of 1.0 to 1.2 as measured thermally at 60 ℃.
6. The method according to claim 4, wherein the drying in the step (2) is vacuum drying under the following conditions: 45 to 65 ℃ and a vacuum degree of-0.09 to-0.04 MPa.
7. The method according to claim 4, wherein the step (2) of pulverizing further comprises granulating the pulverized dry powder.
8. The method according to claim 4, wherein the particle size of the powder ground in the step (2) is 10 to 50 mesh.
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| CN1090965C (en) * | 1999-09-27 | 2002-09-18 | 李亦武 | Compounding of Biannaitong tea as laxative |
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