1302442 & \ 九、發明說明： 【發明所屬之技術領域】 一種可舒緩經痛及經前症候群的機能性飲品，該機能性飲品含益 母草、當歸、川芎、甘草、桂圓、紅棗、乾薑及糖等中藥複方。 【先前技術】 已知可舒緩經期不適或經前症候群之食品主要係爲中藥複方製 劑，其係將各種中藥材分別進行萃取、提煉、煎煮或硏磨等程序後， 將各提煉物或粉末等製成錠劑或膏劑。 例如1999年11月17日公開之中國大陸專利公告第CN1235029 號中披露之一種調經止血藥劑，其係含有九種中藥包括阿膠、黃耆、 仙鶴草、黨參、白芍、當歸、佛手、茜草及續斷；以及輔料包括白 糖或乳糖酒精所組成。該CN1235029號專利亦揭示該藥劑之製造方 法，其係包括：（1)從當歸、佛手兩種中藥中提取揮發油；（2)阿 膠粉碎成中粉，黃耆粉碎成細粉；（3)將當歸、佛手提取揮發油後 的藥渣、黃耆組末以及黨參、白芍、茜草、仙鶴草、續斷加水煎煮； (4)將（3)得到煎液與當歸、佛手提取揮發油後的藥汁合倂，濃 縮成稠膏；（5 )稠膏中加入黃耆生藥細粉、混均、真空乾燥、粉碎； (6)把（5)得到的粉末中加入阿膠粉、白糖或乳糖、混勻、加入 從當歸、佛手提取的揮發油；之後將其製成粒劑，主要功效爲改善 月經障礙。該專利所揭示之治癒率爲20.25%。 _ 又如1999年12月22日公開之中國大陸專利公告第CN1238961 號中所披露的精血再造片，其係由當歸、川芎、白芍、赤芍、丹皮、 黃耆、山藥、伏蒂、澤瀉、人參、五倍子、蒼朮、萸肉、益智仁、 烏賊骨、覆盆子、鹿角、補骨脂、蛇床子、白術、苡仁、甘草及生 薑組成。其所揭示之製法爲將當歸、川芎、白芍、赤芍、丹皮、黃 苠、蒼術、益智仁、覆盆子、補骨脂、蛇床子、白術、甘草及生薑 之萃取液與山藥、茯苓、澤瀉、人蔘、五倍子、瘐肉及苡仁之粉末 製成片劑；主要功效爲調經活血、養血，溫固腎陽，而達治婦女經 5 1302442 W * 痛，月經不調等症。 又如2000年2月16日公開之中國大陸專利公告第CN1244412號 中所披露之理經養顏丸，其係由乳香、沒藥、甘草、肉桂、山楂、 紅棗、元肉、阿膠、生薑、紅糖、蜂蜜、瘦豬肉等製成九劑。該專 利所揭示之功效爲治療久婚不孕症、月經不調、閉經痛經及貧血等。 又如2000年5月3日公開之中國大陸專利公告第CN1251763號 中所披露之一種中藥複方製劑婦科千金片，其係由當歸、黨參、穿 心蓮、單面針、金櫻根、雞血藤、十大功勞及千斤拔組成。該專利 亦揭示其製備方法，包括：（1)選取9重量份的當歸、黨參、穿心蓮， 在粉碎機中粉碎成100目以上的細粉，按至少93.3%的得粉率留取備 用；⑵選取9重量份的單面針及16重量份的金櫻根、雞血藤、十大 功勞及千斤拔五味中藥材，將它們置於多能提取罐中，加上熱水， 並按每2小時提取一次的方法提取兩次，過濾取液；同時將該提取 液在三效液縮器中濃縮成浸膏備用；⑶將已製取的細粉及浸膏混勻 制粒，並通過沸騰乾燥機將其製成乾顆粒，經壓片、包片工序後製 成糖衣片型或薄膜衣型千金片型。該專利所揭示之中藥功效爲祛濕 止痛及調經止痛。 又如2000年6月7日公開之中國大陸專利公告第CN1255339號 中所披露之產婦催乳康復中藥沖劑，其係由當歸、穿山甲、四葉參、 黨參、王不留行、柴胡、黃耆、路路通、青皮、桔梗、鐵馬鞭、麥 冬、通草在內的諸味藥物炮製而成。該中藥沖劑在臨床上具有補氣 養血、疏肝理氣、活血化瘀通絡、調經止痛、催乳、下乳等功效， 可主治婦女產後乳汁分泌少、不下乳以及婦女月經不適、痛經、氣 血兩虛、乳腺炎、乳腺增生、乳房內有腫塊疼痛等疾症。 — 【發明內容】 已知之可調理婦女月經不適、改善經痛之發明係分別將數種中 藥材分別加工再行混合製藥劑。該種藥劑大部分爲錠劑，其服用時 難脫一般傳統中西藥錠劑入口口感不佳之缺點。其次，其所使用之 6 1302442 St ^ 中藥材極多，服用後可能會有潛在之副作用，且其整體之加工程序 繁複，不利於品質之控管，因此需要發展一成份單純且製程簡單之 中藥複方經痛調理食品，其不但可達到良好之製程控管，製成之飲 品除具有理經調經之功效外，風味、口感亦佳。 本發明之中藥複方經痛調理機能性飲品中，該中藥複方包括益母 草、當歸、川芎、甘草、桂圓、紅棗、乾薑及黑糖。製程包括：⑴ 將定量之益母草、當歸、川芎、甘草、桂圓、紅棗、乾薑浸泡於水 中；⑵於高溫下進行萃取；（3)隨時監控該萃取液之糖度値(Brix)，當 糖度値大於2〜4時即終止萃取，並過濾掉所有藥材；（4)將該萃取液 濃縮至糖度値大於7之浸膏備用；⑸此浸膏調配成飲品時，再添加 爲該飮品的0.4〜4%的糖類而成。 本發明之機能性飲品，其主要之功效爲舒緩女性於經前症候群最 主要之症狀，且對於腹部疼痛有減緩，以及調理女性生理期天數之 不正常等。 【實施方式】 於本發明之一具體實施例，爲先加入0.25〜5%益母草、0.2〜2%當 歸、0.05〜0.5%川芎、0.2〜1%甘草、0.1〜2%桂圓、0.2〜1.5%紅棗、 0.02〜0.3%乾薑之組合，加入水中，於80〜90°C以上高溫萃取1小時 後，將藥材去除，再持續高溫濃縮至糖度値大於7後即得浸膏。再 將此浸膏進行飮品調配，添加爲該飲品的0.4〜4%的黑糖而成。 依法大量製備上述浸膏並進行40位人體試驗，受試者爲具有經 期疼痛者，於經前不適感產生時開始服用。服用量爲每日100 ml (其 中含28 ml之糖度値=7之浸膏、3克黑糖、69 ml水），連續服用七日， 分別於使用前、使用後塡寫問卷進行調查，由使用前、後問卷分數 變化，來評估月經不適之症狀並進行統計分析，其結果如下表： 7 1302442 檢定統計量 項目 Ρ値 使用後改善情況 是否具有顯著差異 下腹絞痛 0.032 氺 腰酸背痛 0.000 氺 頭痛 0.022 氺 腹部腫脹 0.001 氺 乳房脹痛 0.000 氺 噁心/D區吐 0.413 腹瀉/便祕 0.003 氺 疲倦想睡 0.024 氺 神糸至質/易怒 0.001 氺 大腿肌肉痛 0.031 氺 骨盆疼痛 0.005 氺 腹部隱隱痛 0.009 氺 下腹絞痛 0.097 皮膚紅斑 0.571 發燒/怕冷 0.115 頻尿 0.041 氺 消化不良 0.004 本 陰道有膿狀分泌物 0.048 氺 經ΠΤί量多 0.454 經血流不止 0.059 生理期時間過長或過短 0.078 生理週期紊亂 0.109 (*:p値<0.05具有顯著差異) 根據統計結果，對於乳房脹痛、神經質/易怒、腹部隱隱痛、生 理期天數不正常等具有改善效果，且利用統計分析具有顯著之差 異，其中乳房脹痛、神經質/易怒這兩項爲女性於『經前症候群』時 主要之症狀，而腹部隱隱痛、生理期天數不正常這兩者則爲『經期 期間』時之症狀。此人體試驗能舒緩女性於經前症候群最主要之症 狀，且對於腹部疼痛有減緩，以及調理女性生理期天數之不正常， 此結果顯示本發明所使用之中藥複方能有效舒緩經期之不適。 1302442 w > 【圖式簡單說明】 Μ j\\\ 【主要元件符號說明】1302442 & \ IX, invention description: [Technical field of invention] A functional drink that can relieve menstrual pain and premenstrual syndrome, including functional motherwort, angelica, Chuanxiong, licorice, longan, red dates, dried ginger and sugar Wait for Chinese herbal compound. [Prior Art] It is known that the foods which can relieve menstrual discomfort or premenstrual syndrome are mainly Chinese herbal compound preparations, which are obtained by extracting, refining, boiling or honing various Chinese herbal medicines, respectively, and then extracting the respective extracts or powders. Or a tablet or paste. For example, a menstruation hemostasis agent disclosed in Chinese Patent Publication No. CN1235029 published on November 17, 1999, which contains nine kinds of traditional Chinese medicines including Ejiao, Astragalus, Agrimony, Codonopsis, Angelica, Angelica, Bergamot, Valerian and Continued interruption; and excipients consisting of sugar or lactose alcohol. The CN1235029 patent also discloses a method for manufacturing the medicament, which comprises: (1) extracting volatile oil from two traditional Chinese medicines of angelica and bergamot; (2) crushing the gelatin into medium powder, and crushing the astragalus into fine powder; (3) Angelica and bergamot extract the volatile oil, the sputum of the Astragalus membranaceus, and the Codonopsis pilosula, Radix Paeoniae Alba, Radix Paeoniae Alba, Agrimony, and simmering water; (4) The medicine obtained after extracting the decoction and Angelica and the bergamot to extract the volatile oil The juice is combined and concentrated into a thick paste; (5) the yellow powder of the crude drug is added to the thick paste, mixed, vacuum dried, and pulverized; (6) the powder obtained in (5) is added with gelatin powder, white sugar or lactose. Mix and add the volatile oil extracted from Angelica sinensis and bergamot; then make it into granules, the main function is to improve menstrual disorders. The cure rate disclosed in this patent is 20.25%. _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ , Alisma, ginseng, gallnut, atractylodes, scorpion meat, puzzle kernel, squid bone, raspberry, antler, psoralen, Cnidium, Atractylodes, Coix seed, licorice and ginger. The method disclosed by the method is to extract the extracts of Angelica, Chuanxiong, Baiqi, Chishao, Danpi, Astragalus, Atractylodes, Yizhiren, Raspberry, Buguzhi, Cnidium, Atractylodes, Licorice and Ginger with Chinese Yam , 茯苓, 泻, 蔘, gallnut, 瘐 meat and hazelnut powder made into tablets; the main effect is to regulate menstruation, blood, nourishing, warming kidney yang, and Dazhi women through 5 1302442 W * pain, irregular menstruation . For example, it is disclosed in the Chinese Mainland Patent Publication No. CN1244412 published on February 16, 2000, which is composed of frankincense, myrrh, licorice, cinnamon, hawthorn, red dates, yuan meat, gelatin, ginger, Black sugar, honey, lean pork, etc. are made into nine doses. The efficacy revealed by the patent is the treatment of long-term infertility, irregular menstruation, amenorrhea, and anemia. Another example is a traditional Chinese medicine compound preparation gynecological gold tablets disclosed in Chinese Patent Publication No. CN1251763 published on May 3, 2000, which is composed of Angelica, Codonopsis, Andrographis paniculata, Unilateral needle, Golden Sakura, Spatholobus, Top Ten It is composed of merits and merits. The patent also discloses a preparation method thereof, comprising: (1) selecting 9 parts by weight of Angelica sinensis, Codonopsis pilosula, and Andrographis paniculata, pulverizing into fine powder of 100 mesh or more in a pulverizer, and retaining at least 93.3% of the powder yield; (2) Select 9 parts by weight of single-sided needles and 16 parts by weight of sakura root, spatholobus, top ten credits and Chinese herbal medicines, and place them in multi-energy extraction tanks, add hot water, and extract them every 2 hours. The method is extracted twice in one time, and the liquid is collected by filtration; at the same time, the extract is concentrated into a dipstick in a three-effect liquid shrinker for use; (3) the prepared fine powder and the extract are mixed and granulated, and passed through a boiling dryer. It is made into dry granules, and after being tableted and packaged, it is made into a sugar-coated sheet type or a film-coated type of gold-plated sheet. The efficacy of the Chinese medicine disclosed in the patent is dampness, pain relief and menstruation and pain relief. Another example is the maternal lactation rehabilitation Chinese medicine granule disclosed in the Chinese Patent Publication No. CN1255339 published on June 7, 2000, which is composed of Angelica, Pangolin, Sishen, Dangshen, Wang Buliu, Bupleurum, and Astragalus. Lulutong, green skin, platycodon grandiflorum, iron horse whip, Ophiopogon japonicus, and through grass are all made from various flavors of drugs. The traditional Chinese medicine granule has the effects of tonifying qi and nourishing blood, soothing liver and regulating qi, promoting blood circulation, relieving phlegm and blood stasis, regulating menstruation and relieving pain, prolactin and lowering milk. It can treat women with less postpartum milk secretion, no milk, and menstrual discomfort, dysmenorrhea and qi. Blood deficiency, mastitis, hyperplasia of the breast, swelling of the breast and other diseases. — 【Contents】 The known inventions for regulating menstrual discomfort and improving menstrual pain in women are separately processed into several mixed pharmaceutical preparations. Most of the medicaments are lozenges, which are difficult to take off when the traditional Chinese medicine and western medicine tablets have poor mouthfeel. Secondly, the 6 1302442 St ^ Chinese herbal medicines used are extremely numerous, and there may be potential side effects after taking them. The overall processing procedure is complicated, which is not conducive to the quality control. Therefore, it is necessary to develop a simple and simple Chinese medicine. The compound warp-regulating food can not only achieve good process control, but also has a flavor and taste in addition to the effect of regulating the warp. In the traditional Chinese medicine compound pain-regulating functional drink of the present invention, the traditional Chinese medicine compound includes motherwort, angelica, Chuanxiong, licorice, longan, red date, dried ginger and brown sugar. The process includes: (1) soaking the quantitative motherwort, angelica, Chuanxiong, licorice, longan, red dates, dried ginger in water; (2) extracting at high temperature; (3) monitoring the sugar content of the extract (Brix) at any time, when the sugar content is 値When it is greater than 2~4, the extraction is terminated, and all the herbs are filtered out; (4) the extract is concentrated to an extract having a sugar content of more than 7; (5) when the extract is blended into a drink, it is added as 0.4 of the product. ~4% of sugar is made. The main function of the functional drink of the present invention is to relieve the female's main symptoms in the premenstrual syndrome, and to slow down the abdominal pain and to adjust the abnormality of the female physiological period. [Embodiment] In one embodiment of the present invention, 0.25~5% motherwort, 0.2~2% angelica, 0.05~0.5% Chuanxiong, 0.2~1% licorice, 0.1~2% longan, 0.2~1.5% are added first. The combination of jujube, 0.02~0.3% dried ginger, added to water, and extracted at a high temperature of 80-90 ° C for 1 hour, the medicinal material is removed, and then concentrated at a high temperature until the sugar content is greater than 7, the extract is obtained. The extract is then blended with the product and added as 0.4 to 4% brown sugar of the drink. The above extracts were prepared in large quantities according to the law and 40 human subjects were tested. The subjects were those with menstrual pain and started taking them before the premenstrual discomfort. The dosage is 100 ml per day (including 28 ml of sugar 値=7 extract, 3 g of brown sugar, 69 ml of water), and it is taken for 7 consecutive days, and the questionnaire is written before use and after use. Before and after the questionnaire score changes, to assess the symptoms of menstrual discomfort and statistical analysis, the results are as follows: 7 1302442 Verification statistics items 改善 improved after use whether there is a significant difference in lower abdominal cramps 0.032 氺 back pain 0.000 氺 headache 0.022 氺 Abdominal swelling 0.001 氺 Breast pain 0.000 氺 nausea / D area spit 0.413 diarrhea / constipation 0.003 氺 tired to sleep 0.024 氺 糸 糸 / 易 易 0.001 氺 氺 氺 肌肉 0.0 0.0 0.0 31 31 31 31 31 31 31 31 31 31 31 31 31 31 31 31 31 31 31 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 Lower abdominal cramps 0.097 Skin erythema 0.571 Fever / Fear cold 0.115 Frequent urinary 0.041 氺 Indigestion 0.004 This vagina has pus-like secretions 0.048 氺 ΠΤ ΠΤ 量 0.45 0.45 0.45 0.45 0.45 0.45 0.45 0.45 0.45 0.45 0.45 0.45 0.45 0.45 0.45 0.45 0.45 0.45 0.45 0.45 0.45 0.45 0.45 0.45 0.45 0.45 0.45 0.45 0.45 0.45 0.45 0.45 0.45 0.45 0.45 0.45 0.45 0.45 0.109 (*:p値<0.05 is significantly different) According to the statistical results, for breast pain , neuroticism / irritability, abdominal faint pain, abnormal number of days in the physiological period have improved effects, and statistical analysis has significant differences, in which breast pain, nervousness / irritability are two women in the "premenstrual syndrome" The main symptoms, while the faint pain in the abdomen and the abnormal number of days in the physiological period are the symptoms during the "menstrual period". This human test can alleviate the most common symptoms of women in premenstrual syndrome, and slow down the abdominal pain, as well as the abnormality of the number of days in the physiological period of the female. This result shows that the traditional Chinese medicine compound used in the present invention can effectively relieve menstrual discomfort. 1302442 w > [Simple description of the diagram] Μ j\\\ [Description of main component symbols]