CN110898137A - Pills for treating hyperthyroidism and preparation method and application thereof - Google Patents
Pills for treating hyperthyroidism and preparation method and application thereof Download PDFInfo
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
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- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
- A61P5/16—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4 for decreasing, blocking or antagonising the activity of the thyroid hormones
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
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- A61K2236/30—Extraction of the material
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- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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Abstract
The invention discloses a pill for treating hyperthyroidism and a preparation method and application thereof, and relates to the technical field of traditional Chinese medicines, wherein the pill comprises the following raw materials in parts by weight: 2-4 parts of gentian, 2-4 parts of scutellaria baicalensis, 1-3 parts of gardenia, 3-5 parts of rhizoma alismatis, 1-2 parts of angelica, 0.005-0.01 part of golden flower, 2-4 parts of radix rehmanniae recen and 8-12 parts of dark green tea. The pill provided by the invention uses pure natural Chinese herbal medicines, reduces adverse effects of medicine residues on a human body through extraction, is convenient to use, low in medicine dosage, green and environment-friendly, has an obvious curative effect of treating hyperthyroidism, has a total effective rate of 100%, does not have side effects, and does not cause secondary harm to the body due to no hormone.
Description
Technical Field
The invention relates to the technical field of traditional Chinese medicines, and in particular relates to pills for treating hyperthyroidism as well as a preparation method and application thereof.
Background
Hyperthyroidism, called hyperthyroidism for short, the thyroid hormone of the thyroid gland of a patient secretes too much, so that the metabolism of three substances, namely sugar, protein and fat is enhanced, and the patient can have a series of symptoms, such as intolerance of heat, hyperhidrosis, dysphoria, irritability, palpitation, hand trembling and the like.
There are three methods for treating hyperthyroidism: drug therapy, surgical therapy, and iodine 131 therapy. The drug therapy can only control the synthesis of thyroid hormone, the long-term administration time of most patients is generally from one year to two years, and most of the existing drugs for treating hyperthyroidism are western medicines which have side effects after being taken for a long time; surgery and iodine 131 treatment can only be performed under conditions in which the condition of the disease is relieved after the medicine is taken; the long course of treatment and the unobvious treatment effect can cause the patients to have bad emotion, which leads to the aggravation of the illness.
The traditional Chinese medicine has more obvious curative effect on hyperthyroidism, but decoction is generally used, and patients need to take a large amount of medicine for a long time, and often cannot insist on taking the medicine intermittently, so that effective treatment cannot be achieved.
Disclosure of Invention
Aiming at the defects in the prior art, the invention provides a pill for treating hyperthyroidism, which comprises the following raw materials in parts by weight: 2-4 parts of gentian, 2-4 parts of scutellaria baicalensis, 1-3 parts of gardenia, 3-5 parts of rhizoma alismatis, 1-2 parts of angelica, 0.005-0.01 part of golden flower, 2-4 parts of radix rehmanniae recen and 8-12 parts of dark green tea.
Preferably, the feed comprises the following raw material components in parts by weight: 2-3 parts of gentian, 2-3 parts of scutellaria baicalensis, 1-2 parts of gardenia, 3-4 parts of rhizoma alismatis, 1-1.5 parts of angelica, 0.005-0.0075 parts of golden flower, 2-3 parts of radix rehmanniae recen and 8-10 parts of dark green tea.
Further preferably, the feed comprises the following raw material components in parts by weight: 3 parts of gentian, 3 parts of scutellaria, 2 parts of gardenia, 4 parts of rhizoma alismatis, 1.5 parts of angelica, 0.0075 parts of golden flower, 3 parts of radix rehmanniae recen and 10 parts of dark green tea.
The preparation method of the pill comprises the following steps: s1, cleaning and airing raw material components to prepare an aired traditional Chinese medicine; s2, crushing the dried traditional Chinese medicine, adding an extracting agent into the crushed traditional Chinese medicine, stirring, heating, purifying and centrifuging to obtain a first extracting solution and a first solid residue; s3, adding an extracting agent into the first solid residue, stirring, heating and purifying to obtain a second extracting solution and second solid residue; s4, mixing the first extracting solution and the second extracting solution, heating, and concentrating under reduced pressure to obtain a concentrated extract; and S5, preparing the concentrated extract into pills, and drying to obtain the pills.
The heating purification in the step S2 is heating to 40-50 ℃ for purification for 3 h; the heating purification in the step S3 is heating to 40-60 ℃ for purification for 3 h.
The extractant in the step S2 is methanol; the weight part ratio of the extractant to the aired traditional Chinese medicine is 1: 2 to 1: 10; the extractant in the step S3 is methanol; the weight part ratio of the extracting agent to the first solid residue is 1: 2 to 1: 10.
the heating in the step S4 is heating to 60 ℃; the reduced pressure concentration is carried out until the weight part ratio of concentrated extract to the dried traditional Chinese medicine is 1: 20.
the drying in the step S5 is drying in an oven at 55-75 ℃.
The weight of the pill in step S5 is 0.8 g.
The invention also aims to protect the application of the pills prepared by the preparation method as a medicine for treating hyperthyroidism.
The invention has the following effects of the traditional Chinese medicine components:
gentian: bitter and cold in nature and taste. It enters liver and gallbladder meridians. The function is as follows: clear heat and dry dampness, purge liver and arrest convulsion. Can be used for treating jaundice due to damp-heat pathogen, stranguria with urine, pudendal swelling, pudendal pruritus, leukorrhagia due to damp-heat pathogen, headache due to excessive fire of liver and gallbladder, conjunctival congestion, ear swelling, deafness, hypochondriac pain, bitter taste in mouth, and convulsion due to febrile convulsion.
Scutellaria baicalensis: bitter in flavor and cold in nature. It enters lung, gallbladder, spleen, large intestine and small intestine meridians. The function is as follows: clear heat and dry dampness, purge fire and remove toxicity, stop bleeding, prevent abortion. Can be used for treating damp-warm syndrome, summer-heat dampness, chest distress, emesis, dampness and heat distention, dysentery, jaundice, cough due to lung heat, hyperpyrexia, polydipsia, hematemesis, carbuncle, swelling, sore, and threatened abortion.
Gardenia: bitter in flavor and cold in nature. It enters heart, lung and triple energizer meridians. The function is as follows: purging pathogenic fire, relieving restlessness, clearing away heat, promoting diuresis, cooling blood, and removing toxic substances; it can be used topically for relieving swelling and pain. Can be used for treating febrile vexation, damp-heat jaundice, stranguria with pain, hematemesis, epistaxis, conjunctival congestion, swelling and pain, and pyocutaneous disease due to fire toxin, and for treating sprain, contusion and pain.
Rhizoma alismatis: sweet in nature and taste, cold in nature. It enters kidney and bladder meridians. The function is as follows: induce diuresis, drain dampness and purge heat. Can be used for treating dysuria, edema, emesis, dysentery, phlegm retention, loempe, gonorrhea, and hematuria.
Chinese angelica: sweet in nature and taste, warm in nature. It enters liver, heart and spleen meridians. The function is as follows: tonify blood, activate blood, regulate menstruation, alleviate pain, moisten dryness and smooth intestine. Can be used for treating blood deficiency syndrome, menoxenia, amenorrhea, dysmenorrhea, abdominal mass, metrorrhagia, asthenia cold, abdominal pain, flaccidity arthralgia, numbness of skin, intestinal dryness, constipation, dysentery, carbuncle, skin sore, and traumatic injury.
Golden flower: pungent and warm in nature and flavor. It enters liver meridian. The function is as follows: dispelling pathogenic wind, removing dampness, promoting blood circulation, and stopping bleeding. Can be used for treating rheumatalgia and hemorrhage.
Dried rehmannia root: sweet in nature and taste, cold in nature. It enters heart, liver and kidney meridians. The function is as follows: clear heat and cool blood, nourish yin, promote the production of body fluid. Can be used for treating fever with deep-red tongue, polydipsia, yin deficiency, internal heat, bone steaming, internal heat, diabetes, hematemesis, epistaxis, macula, and eruption.
The dark tea contains rich nutrient components, wherein the most important components are vitamins and minerals, and also contains proteins, amino acids, saccharides and the like. The black tea has the effects of relieving oil, reducing fat, resisting cancer, resisting oxidation, lowering blood pressure and blood sugar, sterilizing, diminishing inflammation, promoting urination and removing toxic substances.
The invention also aims to protect the application of the pills prepared by the preparation method as a medicine for treating hyperthyroidism.
The invention has the beneficial effects that: the pill provided by the invention uses pure natural Chinese herbal medicines, reduces adverse effects of medicine residues on a human body through extraction, is convenient to use, low in medicine dosage, green and environment-friendly, has an obvious curative effect of treating hyperthyroidism, has a total effective rate of 100%, does not have side effects, and does not cause secondary harm to the body due to no hormone.
Detailed Description
Hereinafter, embodiments of the present invention will be described in detail. The following examples are only for illustrating the technical solutions of the present invention more clearly, and therefore are only examples, and the protection scope of the present invention is not limited thereby.
It is to be noted that, unless otherwise specified, technical or scientific terms used herein shall have the ordinary meaning as understood by those skilled in the art to which the invention pertains.
Example 1
A pill for treating hyperthyroidism comprises the following raw materials in parts by weight: 3 parts of gentian, 3 parts of scutellaria, 2 parts of gardenia, 4 parts of rhizoma alismatis, 1.5 parts of angelica, 0.0075 parts of golden flower, 3 parts of radix rehmanniae recen and 10 parts of dark green tea.
The preparation method of the pill comprises the following steps: s1, cleaning and airing raw material components to prepare an aired traditional Chinese medicine; s2, crushing the dried traditional Chinese medicine, adding an extracting agent into the crushed traditional Chinese medicine, stirring, heating, purifying and centrifuging to obtain a first extracting solution and a first solid residue; s3, adding an extracting agent into the first solid residue, stirring, heating and purifying to obtain a second extracting solution and second solid residue; s4, mixing the first extracting solution and the second extracting solution, heating, and concentrating under reduced pressure to obtain a concentrated extract; and S5, preparing the concentrated extract into pills, and drying to obtain the pills.
The heating purification in the step S2 is heating to 45 ℃ for extraction for 3 h; the heating purification in the step S3 is heating to 50 ℃ for extraction for 3 h.
The extractant in the step S2 is methanol; the weight part ratio of the extractant to the aired traditional Chinese medicine is 1: 6; the extractant in the step S3 is methanol; the weight part ratio of the extracting agent to the first solid residue is 1: 6.
the heating in the step S4 is heating to 60 ℃; the reduced pressure concentration is carried out until the weight part ratio of concentrated extract to the dried traditional Chinese medicine is 1: 20.
the drying in the step S5 is to place the mixture in a 65 ℃ oven for drying.
The weight of the pill in step S5 is 0.8 g.
Example 2
A pill for treating hyperthyroidism comprises the following raw materials in parts by weight: 2 parts of gentian, 2 parts of scutellaria baicalensis, 1 part of gardenia, 5 parts of rhizoma alismatis, 2 parts of angelica, 0.01 part of golden flower, 4 parts of radix rehmanniae recen and 12 parts of dark green tea.
The preparation method of the pill comprises the following steps: s1, cleaning and airing raw material components to prepare an aired traditional Chinese medicine; s2, crushing the dried traditional Chinese medicine, adding an extracting agent into the crushed traditional Chinese medicine, stirring, heating, purifying and centrifuging to obtain a first extracting solution and a first solid residue; s3, adding an extracting agent into the first solid residue, stirring, heating and purifying to obtain a second extracting solution and second solid residue; s4, mixing the first extracting solution and the second extracting solution, heating, and concentrating under reduced pressure to obtain a concentrated extract; and S5, preparing the concentrated extract into pills, and drying to obtain the pills.
The heating purification in the step S2 is heating to 45 ℃ for extraction for 3 h; the heating purification in the step S3 is heating to 50 ℃ for extraction for 3 h.
The extractant in the step S2 is methanol; the weight part ratio of the extractant to the aired traditional Chinese medicine is 1: 6; the extractant in the step S3 is methanol; the weight part ratio of the extracting agent to the first solid residue is 1: 6.
the heating in the step S4 is heating to 60 ℃; the reduced pressure concentration is carried out until the weight part ratio of concentrated extract to the dried traditional Chinese medicine is 1: 20.
the drying in the step S5 is to place the mixture in a 65 ℃ oven for drying.
The weight of the pill in step S5 is 0.8 g.
Example 3
A pill for treating hyperthyroidism comprises the following raw materials in parts by weight: 4 parts of gentian, 4 parts of scutellaria baicalensis, 3 parts of gardenia, 3 parts of rhizoma alismatis, 1 part of angelica sinensis, 0.005 part of golden flower, 2 parts of radix rehmanniae recen and 8 parts of dark green tea.
The preparation method of the pill comprises the following steps: s1, cleaning and airing raw material components to prepare an aired traditional Chinese medicine; s2, crushing the dried traditional Chinese medicine, adding an extracting agent into the crushed traditional Chinese medicine, stirring, heating, purifying and centrifuging to obtain a first extracting solution and a first solid residue; s3, adding an extracting agent into the first solid residue, stirring, heating and purifying to obtain a second extracting solution and second solid residue; s4, mixing the first extracting solution and the second extracting solution, heating, and concentrating under reduced pressure to obtain a concentrated extract; and S5, preparing the concentrated extract into pills, and drying to obtain the pills.
The heating purification in the step S2 is heating to 45 ℃ for extraction for 3 h; the heating purification in the step S3 is heating to 50 ℃ for extraction for 3 h.
The extractant in the step S2 is methanol; the weight part ratio of the extractant to the aired traditional Chinese medicine is 1: 6; the extractant in the step S3 is methanol; the weight part ratio of the extracting agent to the first solid residue is 1: 6.
the heating in the step S4 is heating to 60 ℃; the reduced pressure concentration is carried out until the weight part ratio of concentrated extract to the dried traditional Chinese medicine is 1: 20.
the drying in the step S5 is to place the mixture in a 65 ℃ oven for drying.
The weight of the pill in step S5 is 0.8 g.
Example (b):
the pill prepared in the embodiment 1 of the invention has the following analysis of using effect:
the using method comprises the following steps: it is administered with warm water 3 times daily, 1 pill each time.
Local confirmed hyperthyroidism patients were selected for clinical observation, and the results are shown in table 1:
TABLE 1
Case 1
The disease is diagnosed as hyperthyroidism by the birth of the bear, the disease is cured in 3 months after the bear takes the pill provided by the invention.
Case 2
The king lady starts to have light and protruding eyeball and moderate swelling of thyroid gland half a year ago, the hyperthyroidism disease is diagnosed when the king lady visits the doctor, and the king lady can be cured in 3 months after taking the pills provided by the invention.
Finally, it should be noted that: the above embodiments are only used to illustrate the technical solution of the present invention, and not to limit the same; while the invention has been described in detail and with reference to the foregoing embodiments, it will be understood by those skilled in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some or all of the technical features may be equivalently replaced; such modifications and substitutions do not depart from the spirit and scope of the present invention, and they should be construed as being included in the following claims and description.
Claims (10)
1. A pill for treating hyperthyroidism is characterized in that: the material comprises the following raw material components in parts by weight: 2-4 parts of gentian, 2-4 parts of scutellaria baicalensis, 1-3 parts of gardenia, 3-5 parts of rhizoma alismatis, 1-2 parts of angelica, 0.005-0.01 part of golden flower, 2-4 parts of radix rehmanniae recen and 8-12 parts of dark green tea.
2. The pill according to claim 1, wherein: the material comprises the following raw material components in parts by weight: 2-3 parts of gentian, 2-3 parts of scutellaria baicalensis, 1-2 parts of gardenia, 3-4 parts of rhizoma alismatis, 1-1.5 parts of angelica, 0.005-0.0075 parts of golden flower, 2-3 parts of radix rehmanniae recen and 8-10 parts of dark green tea.
3. Pill according to claim 2, characterized in that: the material comprises the following raw material components in parts by weight: 3 parts of gentian, 3 parts of scutellaria, 2 parts of gardenia, 4 parts of rhizoma alismatis, 1.5 parts of angelica, 0.0075 parts of golden flower, 3 parts of radix rehmanniae recen and 10 parts of dark green tea.
4. A process for the preparation of pellets as claimed in any one of claims 1 to 3, characterized in that: the preparation method comprises the following steps: s1, cleaning and airing raw material components to prepare an aired traditional Chinese medicine; s2, crushing the dried traditional Chinese medicine, adding an extracting agent into the crushed traditional Chinese medicine, stirring, heating, purifying and centrifuging to obtain a first extracting solution and a first solid residue; s3, adding an extracting agent into the first solid residue, stirring, heating and purifying to obtain a second extracting solution and second solid residue; s4, mixing the first extracting solution and the second extracting solution, heating, and concentrating under reduced pressure to obtain a concentrated extract; and S5, preparing the concentrated extract into pills, and drying to obtain the pills.
5. The method of claim 4, wherein: the heating purification in the step S2 is heating to 40-50 ℃ for purification for 3 h; the heating purification in the step S3 is heating to 40-60 ℃ for purification for 3 h.
6. The method of claim 4, wherein: the extractant in the step S2 is methanol; the weight part ratio of the extractant to the aired traditional Chinese medicine is 1: 2 to 1: 10; the extractant in the step S3 is methanol; the weight part ratio of the extracting agent to the first solid residue is 1: 2 to 1: 10.
7. the method of claim 4, wherein: the heating in the step S4 is heating to 60 ℃; the reduced pressure concentration is carried out until the weight part ratio of concentrated extract to the dried traditional Chinese medicine is 1: 20.
8. the method of claim 4, wherein: the drying in the step S5 is drying in an oven at 55-75 ℃.
9. The method of claim 4, wherein: the weight of the pill in step S5 is 0.8 g.
10. The use of the pill prepared by the preparation method of claim 4 as a medicine for treating hyperthyroidism.
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| CN201911376798.9A CN110898137A (en) | 2019-12-27 | 2019-12-27 | Pills for treating hyperthyroidism and preparation method and application thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113893297A (en) * | 2021-09-15 | 2022-01-07 | 山东新时代药业有限公司 | New application of pharmaceutical composition in preparation of medicines for treating thyrotoxicosis |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113893297A (en) * | 2021-09-15 | 2022-01-07 | 山东新时代药业有限公司 | New application of pharmaceutical composition in preparation of medicines for treating thyrotoxicosis |
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Application publication date: 20200324 |