CN110604787A - Medicine for treating hypertension and preparation method thereof - Google Patents
Medicine for treating hypertension and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a medicine for treating hypertension, which comprises the following raw material medicines in parts by weight: 10-20 parts by weight of polygonatum; 14-18 parts of cassia seed; 7-15 parts of chrysanthemum; 4-6 parts of astragalus; 0.5-1 part by weight of harlequin glorybower leaf. The medicine for treating hypertension has obvious improvement and regulation effects on hypertension of different degrees; the raw materials for treating hypertension comprise polygonatum, cassia seed, chrysanthemum, astragalus, harlequin glorybower leaf, motherwort fruit, Chinese mosla herb, shrubalthea flower, broadleaf holly leaf, earthworm, Chinese buckeye seed and erycibe obtusifolia.
Description
Technical Field
The invention relates to the technical field of traditional Chinese medicines, in particular to a medicine for treating hypertension and a preparation method thereof.
Background
Hypertension is a systemic chronic disease mainly caused by continuous increase of circulating arterial blood pressure, and has a tendency of gradually reducing the onset age in recent years, and the incidence of long-term mental stress lack of physical activity, genetic factors, obesity and salt excess is high. At present, the medicine for reducing blood pressure is mainly prepared from western medicines, the western medicines have great side effects and great dependence in treatment and need to be taken for a long time, the most important point is unstable blood pressure reduction, the blood pressure is suddenly high and suddenly low in the medicine taking process, the disease roots cannot be removed, and the blood pressure is instantly increased once the medicine is stopped. Pure traditional Chinese medicines are also used for treatment, but the treatment effect is generally not obvious.
Disclosure of Invention
Aiming at the defects, the invention aims to provide the medicine for treating the hypertension, which has good effect on treating the hypertension and small toxic and side effects.
The technical scheme of the invention is summarized as follows:
the medicine for treating hypertension comprises the following raw material medicines in parts by weight:
preferably, the medicine for treating hypertension further comprises 2-4 parts by weight of motherwort fruit.
Preferably, the medicine for treating hypertension further comprises 1-3 parts by weight of elsholtzia.
Preferably, the medicine for treating hypertension further comprises 2-4 parts by weight of hibiscus flower.
Preferably, the medicine for treating hypertension further comprises 1-3 parts by weight of broadleaf holly leaf.
Preferably, the medicine for treating hypertension further comprises 0.5-2 parts by weight of earthworm.
Preferably, the medicine for treating hypertension further comprises 0.5-2 parts by weight of buckeye.
Preferably, the medicine for treating hypertension further comprises 1-3 parts by weight of caulis Erycibes.
A preparation method of a medicine for treating hypertension comprises the following steps:
1) and (3) breaking the wall at low temperature: setting the raw materials of polygonatum, cassia seed, chrysanthemum, astragalus, harlequin glorybower leaf, motherwort fruit, elsholtzia, hibiscus flower, broadleaf holly leaf, earthworm, Chinese buckeye and erycibe obtusifolia in the formula at the temperature of minus 15-minus 20 ℃, and breaking the cell wall of the raw material medicine by a wall breaking machine to expose the effective components in the cell;
2) extraction and purification: putting the polygonatum odoratum, the cassia seed, the chrysanthemum, the astragalus membranaceus, the harlequin glorybower leaf, the motherwort fruit, the elsholtzia, the shrubalthea flower, the broadleaf holly leaf, the earthworm, the buckeye seed and the male erycibe stem after the wall breaking in the step 1) into an extraction kettle, adding ethanol with the mass concentration of 20% and the weight which is 10-12 times that of the wall breaking raw material medicines into the extraction kettle, extracting the mixture for 2-4 hours, and filtering the mixture to obtain filtrate;
3) evaporating the filtrate and concentrating to obtain soft extract;
4) adding adjuvants into the extract, stirring, drying, pulverizing into 100 mesh fine powder, and making into clinically acceptable dosage forms by conventional method.
Preferably, the preparation method of the medicine for treating hypertension comprises the steps of treating the wall-broken polygonatum, semen cassiae, chrysanthemum, astragalus membranaceus, harlequin glorybower leaf, motherwort fruit, elsholtzia, hibiscus flower, broadleaf holly leaf, lumbricus, buckeye and erycibe obtusifolia after the step 2) for 5 times, and combining the filtrates after the 5 times; the clinically acceptable dosage form is a tablet or pill.
The invention has the beneficial effects that:
the medicine for treating hypertension has obvious improvement and regulation effects on hypertension of different degrees; the raw materials for treating hypertension comprise polygonatum, cassia seed, chrysanthemum, astragalus, harlequin glorybower leaf, motherwort fruit, Chinese mosla herb, shrubalthea flower, broadleaf holly leaf, earthworm, Chinese buckeye seed and erycibe obtusifolia.
Detailed Description
The present invention is further described in detail below with reference to examples so that those skilled in the art can practice the invention with reference to the description.
The invention discloses a medicine for treating hypertension, which comprises the following raw material medicines in parts by weight:
the flavonoid extracted from rhizoma Polygonati Odorati has effects in lowering blood sugar, blood lipid, and blood pressure; cassia seed, bitter, sweet, salty and slightly cold in nature, enters liver, kidney and large intestine meridians; loosening bowel to relieve constipation, reducing blood lipid and improving eyesight, treating constipation and hyperlipemia, hypertension, removing liver fire for improving eyesight, promoting diuresis and relaxing bowels, and lowering blood pressure and blood lipid; the chrysanthemum is sweet and bitter in taste, cold-resistant in nature and has the effects of dispelling wind and clearing heat, clearing liver and improving eyesight, detoxifying and diminishing inflammation and the like; the astragalus can be used as a medicine, has sweet taste and mild nature, has the effects of tonifying qi, strengthening exterior, promoting urination, strengthening heart, reducing blood pressure, resisting bacteria, expelling toxin, expelling pus, promoting granulation, strengthening capillary vessel resistance, arresting sweating and sex hormone-like substances, and is used for treating exterior deficiency spontaneous perspiration, internal injury due to qi deficiency, spleen deficiency diarrhea, edema and carbuncle-abscess; the harlequin glorybower leaf and twig has the effects of expelling wind-damp and reducing blood pressure.
As another embodiment of the present invention, the beverage further comprises 2-4 parts by weight of motherwort fruit. The motherwort fruit has the efficacies of activating blood and regulating menstruation, and clearing liver and improving vision. Can be used for treating menoxenia, amenorrhea, dysmenorrhea, conjunctival congestion, nebula, dizziness, and distending pain.
As another embodiment of the present invention, the composition further comprises 1 to 3 parts by weight of Elsholtzia ciliata. Herba Moslae can be used for treating acute gastroenteritis, abdominal pain, emesis, diarrhea, summer-autumn heatstroke, headache, fever, aversion to cold, anidrosis, cholera, edema, epistaxis, and halitosis.
As another embodiment of the present application, the composition further comprises 2-4 parts by weight of hibiscus flower. Hibiscus flower is sweet and bitter in taste and cool in nature. The medicine has the effects of invigorating spleen, lung and liver channels, clearing heat, promoting diuresis, cooling blood and removing toxic substances; treating intestinal wind and bloody discharge, red and white diarrhea, hemorrhoid hemorrhage, cough due to lung heat, hemoptysis, leucorrhea, skin ulcer furuncle, carbuncle, swelling, scald, etc.
As another embodiment of the present invention, the tea further comprises 1 to 3 parts by weight of Folum Ilicis. The broadleaf holly leaf contains over 200 components such as broadleaf holly leaf saponin, amino acid, vitamin C, polyphenol, flavonoid, caffeine, protein and the like; the finished tea has faint scent and bitter taste, is sweet and cool, and has various effects of clearing away summer heat, improving eyesight, promoting intelligence, promoting the production of body fluid, quenching thirst, promoting urination, strengthening heart, moistening throat, relieving cough, lowering blood pressure, reducing weight, inhibiting and preventing cancer, resisting aging, promoting blood circulation and the like.
As another embodiment of the present disclosure, the wood-plastic composite further comprises 0.5 to 2 parts by weight of earthworms. Earthworm is one of the important Chinese medicinal materials in China; earthworms exist in 67 animal medicines collected in the earliest monograph of traditional Chinese medicine science, Shennong's herbal Jing; listed as the inferior product in Shen nong Ben Cao Jing, it has the effects of clearing heat, arresting convulsion, dredging collaterals, relieving asthma and inducing diuresis. After being stir-baked, the Chinese medicinal composition is used for treating high fever, coma, fright epilepsy and convulsion, arthralgia, cough and asthma due to lung heat, oliguria and edema, hypertension and the like.
As another embodiment of the present disclosure, the composition further comprises 0.5 to 2 parts by weight of buckeye. Semen aesculi is sweet and warm, enters liver and stomach meridians, and is used for regulating qi, relieving epigastric distention, harmonizing stomach and relieving pain. Can be used for treating chest and abdomen distention, gastric cavity pain.
As another embodiment of the present disclosure, the composition further comprises 1 to 3 parts by weight of Erycibes nigrum. The erycibe obtusifolia has pungent taste and warm nature, enters liver, spleen and stomach channels, dispels wind and dampness, and reduces swelling and relieves pain.
A preparation method of a medicine for treating hypertension comprises the following steps:
1) and (3) breaking the wall at low temperature: setting the raw materials of polygonatum, cassia seed, chrysanthemum, astragalus, harlequin glorybower leaf, motherwort fruit, elsholtzia, hibiscus flower, broadleaf holly leaf, earthworm, Chinese buckeye and erycibe obtusifolia in the formula at the temperature of minus 15-minus 20 ℃, and breaking the cell wall of the raw material medicine by a wall breaking machine to expose the effective components in the cell;
2) extraction and purification: putting the polygonatum odoratum, the cassia seed, the chrysanthemum, the astragalus membranaceus, the harlequin glorybower leaf, the motherwort fruit, the elsholtzia, the shrubalthea flower, the broadleaf holly leaf, the earthworm, the buckeye seed and the male erycibe stem after the wall breaking in the step 1) into an extraction kettle, adding ethanol with the mass concentration of 20% and the weight which is 10-12 times that of the wall breaking raw material medicines into the extraction kettle, extracting the mixture for 2-4 hours, and filtering the mixture to obtain filtrate;
3) evaporating the filtrate and concentrating to obtain soft extract;
4) adding adjuvants into the extract, stirring, drying, pulverizing into 100 mesh fine powder, and making into clinically acceptable dosage forms by conventional method.
As another embodiment of the present disclosure, the wall-broken polygonatum odoratum, semen cassiae, chrysanthemum, astragalus membranaceus, harlequin glorybower leaf, motherwort fruit, elsholtzia, hibiscus flower, broadleaf holly leaf, earthworm, buckeye and erycibe obtusifolia are processed for 5 times through the step 2), and the filtrates obtained after 5 times are combined.
Specific examples and comparative examples are listed below:
example 1:
the medicine for treating hypertension comprises the following raw material medicines in parts by weight:
a preparation method of a medicine for treating hypertension comprises the following steps:
1) and (3) breaking the wall at low temperature: setting rhizoma Polygonati Odorati, semen Cassiae, flos Chrysanthemi, radix astragali, folium et ramulus Clerodendri Trichotomi, fructus Leonuri, herba Moslae, flos Hibisci, Folum Ilicis, Lumbricus, semen Aesculi, and caulis Erycibes in the formula at-15 deg.C, and breaking cell wall of the raw materials by cell wall breaking machine to expose effective components in cells;
2) extraction and purification: putting the polygonatum odoratum, the cassia seed, the chrysanthemum, the astragalus membranaceus, the harlequin glorybower leaf, the motherwort fruit, the elsholtzia, the shrubalthea flower, the broadleaf holly leaf, the earthworm, the buckeye seed and the male erycibe stem after the wall breaking in the step 1) into an extraction kettle, adding ethanol with the mass concentration of 20% and the weight which is 10 times that of the wall breaking raw material medicines into the extraction kettle for extraction for 2 hours, and filtering the extraction kettle to obtain filtrate; extracting the residue for 4 times, and treating for 5 times;
3) evaporating the filtrate and concentrating to obtain soft extract;
4) adding adjuvants into the extract, stirring, drying, pulverizing into 100 mesh fine powder, and making into tablet by conventional method.
Example 2:
the medicine for treating hypertension comprises the following raw material medicines in parts by weight:
a preparation method of a medicine for treating hypertension comprises the following steps:
1) and (3) breaking the wall at low temperature: setting rhizoma Polygonati Odorati, semen Cassiae, flos Chrysanthemi, radix astragali, folium et ramulus Clerodendri Trichotomi, fructus Leonuri, herba Moslae, flos Hibisci, Folum Ilicis, Lumbricus, semen Aesculi, and caulis Erycibes in the formula at-18 deg.C, and breaking cell wall of the raw materials by cell wall breaking machine to expose effective components in cells;
2) extraction and purification: putting the polygonatum odoratum, the cassia seed, the chrysanthemum, the astragalus membranaceus, the harlequin glorybower leaf, the motherwort fruit, the elsholtzia, the shrubalthea flower, the broadleaf holly leaf, the earthworm, the buckeye seed and the male erycibe stem after the wall breaking in the step 1) into an extraction kettle, adding ethanol with the mass concentration of 20% and the weight which is 11 times that of the wall breaking raw material medicines into the extraction kettle for extraction for 3 hours, and filtering the extraction kettle to obtain filtrate; treating the residue for 5 times, and mixing the filtrates for 5 times;
3) evaporating the filtrate and concentrating to obtain soft extract;
4) adding adjuvants into the extract, stirring, drying, pulverizing into 100 mesh fine powder, and making into tablet by conventional method.
Example 3:
the medicine for treating hypertension comprises the following raw material medicines in parts by weight:
a preparation method of a medicine for treating hypertension comprises the following steps:
1) and (3) breaking the wall at low temperature: setting the raw materials of polygonatum, cassia seed, chrysanthemum, astragalus, harlequin glorybower leaf, motherwort fruit, elsholtzia, hibiscus flower, broadleaf holly leaf, earthworm, Chinese buckeye and erycibe obtusifolia in the formula at the temperature of minus 15-minus 20 ℃, and breaking the cell wall of the raw material medicine by a wall breaking machine to expose the effective components in the cell;
2) extraction and purification: putting the polygonatum odoratum, the cassia seed, the chrysanthemum, the astragalus membranaceus, the harlequin glorybower leaf, the motherwort fruit, the elsholtzia, the shrubalthea flower, the broadleaf holly leaf, the earthworm, the buckeye seed and the male erycibe stem after the wall breaking in the step 1) into an extraction kettle, adding ethanol with the mass concentration of 20% and the weight which is 12 times that of the wall breaking raw material medicines into the extraction kettle for extraction for 4 hours, and filtering the extraction kettle to obtain filtrate; extracting the residue for 4 times, extracting for 5 times, and mixing the filtrates of 5 times;
3) evaporating the filtrate and concentrating to obtain soft extract;
4) adding adjuvants into the extract, stirring, drying, pulverizing into 100 mesh fine powder, and making into tablet by conventional method.
Comparative example 1:
the medicine for treating hypertension comprises the following raw material medicines in parts by weight:
a preparation method of a medicine for treating hypertension comprises the following steps:
1) and (3) breaking the wall at low temperature: setting rhizoma Polygonati Odorati, semen Cassiae, flos Chrysanthemi, radix astragali, folium et ramulus Clerodendri Trichotomi, herba Moslae, flos Hibisci, Folum Ilicis, Lumbricus, semen Aesculi, and caulis Erycibes in the formula at-15 deg.C, and breaking cell wall of the raw materials by cell wall breaking machine to expose effective components in cells;
2) extraction and purification: putting the polygonatum odoratum, the cassia seed, the chrysanthemum, the astragalus membranaceus, the harlequin glorybower leaf, the elsholtzia, the hibiscus flower, the broadleaf holly leaf, the earthworm, the buckeye seed and the erycibe obtusifolia stem which are subjected to wall breaking in the step 1) into an extraction kettle, adding ethanol with the mass concentration of 20% and the weight which is 10 times that of the wall breaking raw material medicine into the extraction kettle, extracting for 2 hours, and filtering to obtain filtrate; extracting the residue for 4 times, and treating for 5 times;
3) evaporating the filtrate and concentrating to obtain soft extract;
4) adding adjuvants into the extract, stirring, drying, pulverizing into 100 mesh fine powder, and making into tablet by conventional method.
Comparative example 2:
the medicine for treating hypertension comprises the following raw material medicines in parts by weight:
a preparation method of a medicine for treating hypertension comprises the following steps:
1) and (3) breaking the wall at low temperature: setting rhizoma Polygonati Odorati, semen Cassiae, flos Chrysanthemi, radix astragali, folium et ramulus Clerodendri Trichotomi, fructus Leonuri, flos Hibisci, Folum Ilicis, Lumbricus, semen Aesculi, and caulis Erycibes in the formula at-15 deg.C, and breaking cell wall of the raw materials by cell wall breaking machine to expose effective components in cells;
2) extraction and purification: putting the polygonatum odoratum, the cassia seed, the chrysanthemum, the astragalus membranaceus, the harlequin glorybower leaf, the motherwort fruit, the shrubalthea flower, the broadleaf holly leaf, the earthworm, the Chinese buckeye seed and the erycibe obtusifolia stem which are subjected to wall breaking in the step 1) into an extraction kettle, adding ethanol with the mass concentration of 20% and the weight which is 10 times that of the wall breaking raw material medicine into the extraction kettle, extracting for 2 hours, and filtering to obtain filtrate; extracting the residue for 4 times, and treating for 5 times;
3) evaporating the filtrate and concentrating to obtain soft extract;
4) adding adjuvants into the extract, stirring, drying, pulverizing into 100 mesh fine powder, and making into tablet by conventional method.
Comparative example 3:
the medicine for treating hypertension comprises the following raw material medicines in parts by weight:
a preparation method of a medicine for treating hypertension comprises the following steps:
1) and (3) breaking the wall at low temperature: setting rhizoma Polygonati Odorati, semen Cassiae, flos Chrysanthemi, radix astragali, folium et ramulus Clerodendri Trichotomi, fructus Leonuri, herba Moslae, folium Ilicis, Lumbricus, semen Aesculi, and caulis Erycibes in the formula at-18 deg.C, and breaking cell wall of the raw materials by cell wall breaking machine to expose effective components in cells;
2) extraction and purification: putting the polygonatum odoratum, the cassia seed, the chrysanthemum, the astragalus membranaceus, the harlequin glorybower leaf, the motherwort fruit, the elsholtzia, the broadleaf holly leaf, the earthworm, the buckeye and the male erysipelas stem which are subjected to wall breaking in the step 1) into an extraction kettle, adding ethanol with the mass concentration of 20% and the weight which is 11 times that of the wall breaking raw material medicine into the extraction kettle, extracting the mixture for 3 hours, and filtering the mixture to obtain filtrate; treating the residue for 5 times, and mixing the filtrates for 5 times;
3) evaporating the filtrate and concentrating to obtain soft extract;
4) adding adjuvants into the extract, stirring, drying, pulverizing into 100 mesh fine powder, and making into tablet by conventional method. .
Comparative example 4:
the medicine for treating hypertension comprises the following raw material medicines in parts by weight:
a preparation method of a medicine for treating hypertension comprises the following steps:
1) and (3) breaking the wall at low temperature: setting rhizoma Polygonati Odorati, semen Cassiae, flos Chrysanthemi, radix astragali, folium et ramulus Clerodendri Trichotomi, fructus Leonuri, herba Moslae, flos Hibisci, Lumbricus, semen Aesculi, and caulis Erycibes in the formula at-18 deg.C, and breaking cell wall of the raw materials by cell wall breaking machine to expose effective components in cells;
2) extraction and purification: putting the polygonatum odoratum, the cassia seed, the chrysanthemum, the astragalus membranaceus, the harlequin glorybower leaf, the motherwort fruit, the elsholtzia, the hibiscus flower, the earthworm, the buckeye and the erycibe obtusifolia after the wall breaking in the step 1) into an extraction kettle, adding ethanol with the mass concentration of 20% and the weight which is 11 times that of the wall breaking raw material medicine into the extraction kettle, extracting for 3 hours, and filtering to obtain filtrate; treating the residue for 5 times, and mixing the filtrates for 5 times;
3) evaporating the filtrate and concentrating to obtain soft extract;
4) adding adjuvants into the extract, stirring, drying, pulverizing into 100 mesh fine powder, and making into tablet by conventional method. .
Comparative example 5:
the medicine for treating hypertension comprises the following raw material medicines in parts by weight:
a preparation method of a medicine for treating hypertension comprises the following steps:
1) and (3) breaking the wall at low temperature: setting the raw materials of polygonatum, cassia seed, chrysanthemum, astragalus, harlequin glorybower leaf, motherwort fruit, elsholtzia, hibiscus flower, broadleaf holly leaf, earthworm and erycibe obtusifolia in the formula at the temperature of minus 15-minus 20 ℃, and breaking the cell wall of the raw material medicine by a wall breaking machine to expose the effective ingredients in the cell;
2) extraction and purification: putting the polygonatum odoratum, the cassia seed, the chrysanthemum, the astragalus membranaceus, the harlequin glorybower leaf, the motherwort fruit, the elsholtzia, the hibiscus flower, the broadleaf holly leaf, the earthworm and the erycibe obtusifolia after the wall breaking in the step 1) into an extraction kettle, adding ethanol with the mass concentration of 20% and the weight which is 12 times that of the wall breaking raw materials into the extraction kettle, extracting for 4 hours, and filtering to obtain filtrate; extracting the residue for 4 times, extracting for 5 times, and mixing the filtrates of 5 times;
3) evaporating the filtrate and concentrating to obtain soft extract;
4) adding adjuvants into the extract, stirring, drying, pulverizing into 100 mesh fine powder, and making into tablet by conventional method.
Comparative example 6:
the medicine for treating hypertension comprises the following raw material medicines in parts by weight:
a preparation method of a medicine for treating hypertension comprises the following steps:
1) and (3) breaking the wall at low temperature: setting the raw materials of polygonatum, cassia seed, chrysanthemum, astragalus, harlequin glorybower leaf, motherwort fruit, elsholtzia, hibiscus flower, broadleaf holly leaf, earthworm and buckeye in the formula at the temperature of minus 15 ℃ to minus 20 ℃, and breaking the cell wall of the raw material medicine by a wall breaking machine to expose the effective ingredients in the cell;
2) extraction and purification: putting the polygonatum odoratum, the cassia seed, the chrysanthemum, the astragalus membranaceus, the harlequin glorybower leaf, the motherwort fruit, the elsholtzia, the shrubalthea flower, the broadleaf holly leaf, the earthworm and the buckeye seed subjected to wall breaking in the step 1) into an extraction kettle, adding ethanol with the mass concentration of 20% and the weight which is 12 times that of the wall breaking raw material medicine into the extraction kettle, extracting for 4 hours, and filtering to obtain filtrate; extracting the residue for 4 times, extracting for 5 times, and mixing the filtrates of 5 times;
3) evaporating the filtrate and concentrating to obtain soft extract;
4) adding adjuvants into the extract, stirring, drying, pulverizing into 100 mesh fine powder, and making into tablet by conventional method.
Test example 1 clinical study
The clinical data of the traditional Chinese medicine health-care preparation for conditioning hypertension are shown below.
1. Clinical observations subjects: 540 clinically diagnosed patients with typical hypertension were selected, among which 180 cases of primary hypertension, 180 cases of secondary hypertension (moderate) and 180 cases of tertiary hypertension (severe). The male and female are both 40-75 years old, and each group has 60 cases, including 20 cases of primary hypertension, 20 cases of secondary hypertension (moderate) and 20 cases of tertiary hypertension (severe).
2. The treatment method comprises the following steps: when the inventive examples 1 to 3 and the comparative examples 1 to 6 were taken, the specifications were as follows: 1.0 g/tablet. The use method comprises the following steps: the decoction is taken orally with warm boiled water in the morning and evening respectively in 3 tablets. The course of treatment is as follows: 3 months 1 cycle, typically 3 cycles are observed.
3. The therapeutic effect judgment standard is as follows: the blood pressure tends to be normal, and no recurrence phenomenon exists within 3 months after the treatment is stopped as cure; hypertension changes from the third grade to the second grade or the first grade, and the hypertension changes from the second grade to the first grade to be effective; the hypertension was significantly improved to be ineffective.
4. And (3) measuring results: clinical observations are shown in table 1.
The results in table 1 show that the cure rate of the first-grade hypertension of examples 1 to 3 is 100%; the cure rate of the second-grade hypertension is more than 55 percent, and the effective rate is more than 95 percent; the cure rate of the hypertension III is more than 45 percent, and the effective rate is more than 90 percent. Therefore, the medicine of the invention has obvious effects of improving and regulating hypertension of different degrees. The traditional Chinese medicine composition disclosed by the invention is prepared from medicinal and edible traditional Chinese medicinal materials, is free from toxic and side effects, can be eaten for a long time, and avoids the negative effects of western medicine treatment on the body.
While embodiments of the invention have been disclosed above, it is not limited solely to the applications set forth in the specification and illustrated embodiments, but it is well within the purview of one skilled in the art to utilize the invention in various fields appropriate for the invention and with additional specificity to be achieved in the specific details.
Claims (10)
1. The medicine for treating hypertension is characterized by comprising the following raw material medicines in parts by weight:
2. the medicine for treating hypertension according to claim 1, further comprising 2 to 4 parts by weight of motherwort fruit.
3. The medicament for treating hypertension according to claim 1, further comprising 1 to 3 parts by weight of elsholtzia.
4. The medicament for treating hypertension according to claim 1, further comprising 2 to 4 parts by weight of hibiscus flower.
5. The drug for treating hypertension according to claim 1, further comprising 1 to 3 parts by weight of broadleaf holly leaf.
6. The medicament for treating hypertension according to claim 1, further comprising 0.5 to 2 parts by weight of earthworm.
7. The medicament for treating hypertension according to claim 1, further comprising 0.5 to 2 parts by weight of buckeye.
8. The medicament for treating hypertension according to claim 1, further comprising 1 to 3 parts by weight of Erycibe obtusifolia.
9. The method for preparing a medicament for treating hypertension according to any one of claims 1 to 8, comprising the steps of:
1) and (3) breaking the wall at low temperature: setting the raw materials of polygonatum, cassia seed, chrysanthemum, astragalus, harlequin glorybower leaf, motherwort fruit, elsholtzia, hibiscus flower, broadleaf holly leaf, earthworm, Chinese buckeye and erycibe obtusifolia in the formula at the temperature of minus 15-minus 20 ℃, and breaking the cell wall of the raw material medicine by a wall breaking machine to expose the effective components in the cell;
2) extraction and purification: putting the polygonatum odoratum, the cassia seed, the chrysanthemum, the astragalus membranaceus, the harlequin glorybower leaf, the motherwort fruit, the elsholtzia, the shrubalthea flower, the broadleaf holly leaf, the earthworm, the buckeye seed and the male erycibe stem after the wall breaking in the step 1) into an extraction kettle, adding ethanol with the mass concentration of 20% and the weight which is 10-12 times that of the wall breaking raw material medicines into the extraction kettle, extracting the mixture for 2-4 hours, and filtering the mixture to obtain filtrate;
3) evaporating the filtrate and concentrating to obtain soft extract;
4) adding adjuvants into the extract, stirring, drying, pulverizing into 100 mesh fine powder, and making into clinically acceptable dosage forms by conventional method.
10. The method for preparing the medicine for treating hypertension according to claim 9, wherein the wall-broken polygonatum odoratum, semen cassiae, chrysanthemum, astragalus membranaceus, harlequin glorybower leaf, motherwort fruit, elsholtzia, hibiscus flower, broadleaf holly leaf, earthworm, buckeye and erycibe obtusifolia are treated for 5 times through the step 2), and the filtrates obtained are combined for 5 times; the clinically acceptable dosage form is a tablet or pill.
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| CN104042936A (en) * | 2014-07-07 | 2014-09-17 | 蚌埠火鹤制药有限公司 | Traditional Chinese medicinal hypertension pill |
| CN104940716A (en) * | 2015-08-04 | 2015-09-30 | 朱克兰 | Foot bath composition for treating high blood pressure and preparation method thereof |
| CN106729123A (en) * | 2017-03-29 | 2017-05-31 | 贵州穗蓝酒业科技有限公司 | A kind of composition of three high drop and preparation method thereof |
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| CN104042936A (en) * | 2014-07-07 | 2014-09-17 | 蚌埠火鹤制药有限公司 | Traditional Chinese medicinal hypertension pill |
| CN104940716A (en) * | 2015-08-04 | 2015-09-30 | 朱克兰 | Foot bath composition for treating high blood pressure and preparation method thereof |
| CN106729123A (en) * | 2017-03-29 | 2017-05-31 | 贵州穗蓝酒业科技有限公司 | A kind of composition of three high drop and preparation method thereof |
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