CN110604782A - Medicine for treating heart disease and preparation method thereof - Google Patents
Medicine for treating heart disease and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a medicine for treating heart diseases, which comprises the following raw material medicines in parts by weight: 20-30 parts of peach kernels; 12-16 parts of poria cocos; 8-15 parts of allium macrostemon; 5-10 parts of cinnamon; 2-4 parts of cortex albiziae; 1-3 parts of radix pseudostellariae. After patients diagnosed with heart diseases continuously take the medicine for 60 days, the medicine for treating heart diseases has the significant ratio of more than 80%, the effective ratio of more than 8% and the ineffective ratio of less than 4%, the raw materials of the medicine for treating heart diseases comprise peach kernels, poria cocos, allium macrostemon, cinnamon, cortex albiziae, radix pseudostellariae, platycladi seeds, folium cortex eucommiae, honey-fried licorice roots, rhizoma dioscoreae, benzoin, radix salviae miltiorrhizae, poria with hostwood and pinellia ternate, the raw materials are reasonably compatible, the unique performance and efficacy of the raw materials are fully exerted, the complementary effects of the raw materials are considered, the medicine effects supplement each other, the heart disease treatment effect is obvious, and no toxic or side effect is caused.
Description
Technical Field
The invention relates to the technical field of traditional Chinese medicines, in particular to a medicine for treating heart diseases and a preparation method thereof.
Background
Heart diseases are a common disease of the circulatory system, and the specific diseases are many. The circulatory system is composed of the heart, blood vessels, and neurohumoral tissues that regulate blood circulation, and circulatory diseases are also known as cardiovascular diseases. Heart diseases are classified according to etiology: congenital heart disease and acquired heart disease. The acquired heart disease refers to the disease caused by the external or internal factors of the body after birth, and mainly comprises the following types: coronary heart disease caused by coronary arteriosclerosis, rheumatic heart disease, hypertensive heart disease, infectious heart disease, endocrine heart disease, hematologic heart disease, and nutritional metabolic heart disease. The heart disease is fast in onset and high in death rate. There is no chronic treatment in the treatment, and many people die due to improper or untimely treatment.
In the past, although treatment medicines such as nitrates, calcium antagonists, receptor blockers and antiplatelet drugs for treating coronary heart disease, angina pectoris, myocardial infarction and heart failure are available in the market, the treatment medicines generally have great side effects. For example, calcium antagonists, which reduce heart load mainly by dilating coronary and systemic arteries, are a common emergency treatment, but dilation of blood vessels easily causes slow heart skipping, heart failure and strong dependence, and sudden death occurs in hypotension patients; nitrates can cause headache, flushing, tinnitus, dizziness and tachycardia, and sometimes can cause rapid blood pressure drop, collapse and drug resistance; the receptor blocker has strong dependence, and the condition is more serious when the drug is stopped suddenly; antiplatelet drugs cause gastrointestinal bleeding and other side effects. Otherwise, the effect cannot be imagined. The medicine has single function, and can treat the symptoms and root causes, so the aim of radical treatment is often not achieved. When the doctor repeatedly uses the treatment means and the treatment means are ineffective, the doctor still performs operations, installs a bracket, bridges the heart and the like, the treatment is still a temporary treatment and a permanent treatment, the treatment effect is poor, the treatment cost is high, and most patients cannot bear high treatment cost.
Disclosure of Invention
Aiming at the defects, the invention aims to provide the medicine for treating the heart disease, which has good treatment effect on the heart disease, low cost and no toxic or side effect.
The technical scheme of the invention is summarized as follows:
the medicine for treating heart disease comprises the following raw material medicines in parts by weight:
preferably, the medicine for treating heart disease further comprises 2-4 parts by weight of semen boitae.
Preferably, the medicine for treating heart disease further comprises 0.5-2 parts by weight of eucommia ulmoides leaves.
Preferably, the medicine for treating heart disease further comprises 1-3 parts by weight of honey-fried licorice root.
Preferably, the medicine for treating heart disease further comprises 4-6 parts by weight of Guangdong yam.
Preferably, the medicine for treating heart disease further comprises 1-3 parts by weight of benzoin.
Preferably, the medicine for treating heart disease further comprises 3-5 parts by weight of discorea.
Preferably, the medicine for treating heart disease further comprises 0.5-2 parts by weight of poria with hostwood and 2-5 parts by weight of pinellia ternate.
A preparation method of a medicine for treating heart disease comprises the following steps:
1) and (3) breaking the wall at low temperature: setting the raw materials of peach kernel, tuckahoe, allium macrostemon, cinnamon, cortex albiziae, radix pseudostellariae, platycladi seed, folium cortex eucommiae, honey-fried licorice root, yam rhizome, benzoin, Chinese ladybell root, poria with hostwood and pinellia ternate in the formula at the temperature of minus 15 ℃ to minus 20 ℃, and breaking the cell wall of the raw material medicine by a wall breaking machine to expose the effective components in the cell;
2) extraction and purification: putting the peach kernels, poria cocos, allium macrostemon, cinnamon, cortex albiziae, radix pseudostellariae, platycladi seeds, folium cortex eucommiae, honey-fried licorice roots, rhizoma dioscoreae, benzoin, Chinese ladybell roots, poria cocos and pinellia ternate which are subjected to wall breaking in the step 1) into an extraction kettle, adding 20% ethanol which is 8-10 times of the weight of the wall breaking raw materials, extracting for 3-5 hours, and filtering to obtain filtrate;
3) evaporating the filtrate and concentrating to obtain soft extract;
4) adding adjuvants into the extract, stirring, drying, pulverizing into 100 mesh fine powder, and making into clinically acceptable dosage forms by conventional method.
Preferably, the preparation method of the medicine for treating heart disease comprises the steps of treating the wall-broken peach kernels, poria cocos, allium macrostemon, cinnamon, cortex albiziae, radix pseudostellariae, semen boitae, folium cortex eucommiae, radix glycyrrhizae preparata, rhizoma dioscoreae nipponicae, benzoin, radix salviae miltiorrhizae, poria with hostwood and pinellia ternate for 3 times, and combining the filtrates obtained after 3 times; the dosage form in the step 4) is any one of tablets and pills.
The invention has the beneficial effects that:
the medicine for treating heart diseases has the advantages that after patients diagnosed with heart diseases such as angina pectoris, myocardial infarction and coronary heart disease continuously take the medicine for 60 days, the significant rate reaches more than 80%, the effective rate reaches more than 8%, and the ineffective rate is lower than 4%. The raw materials of the medicine for treating heart disease comprise peach kernel, tuckahoe, allium macrostemon, cinnamon, cortex albiziae, radix pseudostellariae, platycladi seed, folium cortex eucommiae, honey-fried licorice root, dioscorea panthaica, benzoin, Chinese ladybell root, poria with hostwood and pinellia ternate.
Detailed Description
The present invention is further described in detail below with reference to examples so that those skilled in the art can practice the invention with reference to the description.
The invention discloses a medicine for treating heart diseases, which comprises the following raw material medicines in parts by weight:
peach kernel has the effects of activating blood circulation to dissipate blood stasis, moistening intestines to relieve constipation, and relieving cough and asthma; poria has effects in regulating heart, lung, spleen, and kidney meridians, promoting diuresis, eliminating dampness, invigorating spleen, and calming heart; bulbus Allii Macrostemi is pungent and bitter in flavor, has effects of regulating qi-flowing, relieving chest stuffiness, activating yang, and resolving hard mass, and can be used for treating thoracic obstruction, cardialgia, abdominal distention and pain, diarrhea, tenesmus, sore, furuncle, etc.; cinnamon has the functions of warming spleen and stomach, tonifying kidney, dispelling cold and relieving pain, and is used for treating cold pain in waist and knees, deficiency cold stomachache, chronic dyspepsia, abdominal pain, vomiting and diarrhea, and amenorrhea due to cold. The cassia twig has the functions of sweating and expelling pathogenic factors from muscles, warming and dredging channels and collaterals, and is used for treating exogenous cold, cold and aching pain of shoulder, arm and limb joints, and the cassia twig decoction has obvious antibacterial action on staphylococcus aureus, typhoid bacillus and human type mycobacterium tuberculosis; cortex Albizziae is commonly used for treating insomnia and uneasiness due to emotional distress and depression, and for treating heart-qi restlessness, insomnia and muscle spasm; radix pseudostellariae has the effects of tonifying qi and spleen, promoting the production of body fluid and moistening lung. It is commonly used for spleen deficiency, fatigue, anorexia, weakness after illness, deficiency of qi and yin, spontaneous perspiration, thirst, dryness of lung and dry cough.
As another embodiment of the present disclosure, the composition further comprises 2 to 4 parts by weight of semen Platycladi. Semen Platycladi has effects of nourishing heart, tranquilizing mind, loosening bowel, relieving constipation, and arresting sweating, and can be used for treating yin blood deficiency, vexation insomnia, cardiopalmus severe palpitation, constipation due to intestinal dryness, and night sweat due to yin deficiency.
In another embodiment of the present invention, the composition further comprises 0.5 to 2 parts by weight of eucommia ulmoides leaves. The folium Eucommiae has the effects of lowering blood pressure, reducing blood lipid, lowering blood sugar, relieving inflammation, resisting virus, relieving fatigue, strengthening tendons and bones, and resisting aging.
As another embodiment of the present application, the beverage further comprises 1-3 parts by weight of radix glycyrrhizae preparata. The prepared licorice has the treatment effects of tonifying qi, nourishing yin, activating yang and recovering pulse.
As another embodiment of the present disclosure, the yam also includes 4-6 parts by weight of yam. Guang Yam, rhizoma Dioscoreae strengthens the spleen and stomach, promotes the production of body fluid and benefits the lung, tonifies the kidney and astringes essence. They belong to the category of qi tonics under deficiency-tonifying herbs.
As another embodiment of the present invention, the composition further comprises 1 to 3 parts by weight of benzoin. The benzoin has effects of refreshing mind, activating qi-flowing, promoting blood circulation, and relieving pain, and can be used for treating apoplexy with phlegm syncope, qi stagnation with syncope, coma, heart and abdomen pain, puerperal blood faint, and infantile convulsion.
As another embodiment of the present disclosure, the food further comprises 3 to 5 parts by weight of a discorea. The radix seu herba Spiranthis Lanceae has effects of invigorating qi, nourishing yin, clearing heat and detoxicating, and is commonly used for treating asthenia after illness, yin deficiency, internal heat, cough, hematemesis, dizziness, lumbago, soreness and weakness, diabetes, nocturnal emission, stranguria with turbid discharge, swelling and pain of throat, venomous snake bite, scald, fire injury, pyocutaneous disease, carbuncle, and carbuncle swelling.
As another embodiment of the present invention, the composition further comprises 0.5 to 2 parts by weight of poria with hostwood and 2 to 5 parts by weight of pinellia ternate. Fu Shen is sweet and bland in flavor. Rhizoma Pinelliae has effects in eliminating dampness, invigorating spleen, and calming heart, and can be used for treating phlegm retention, edema, dysuresia, diarrhea, palpitation, and vertigo; pinellia ternate eliminates dampness and phlegm, lowers adverse qi and stops vomiting, relieves stuffiness and eliminates stagnation, and is used for treating excessive phlegm cough and asthma, phlegm retention and dizziness and palpitation, wind phlegm dizziness, phlegm syncope headache, vomiting and regurgitation, stuffiness and stuffiness in chest and epigastrium and globus hystericus; unprocessed for treating abscess and phlegm nodule.
A preparation method of a medicine for treating heart disease comprises the following steps:
1) and (3) breaking the wall at low temperature: setting the raw materials of peach kernel, tuckahoe, allium macrostemon, cinnamon, cortex albiziae, radix pseudostellariae, platycladi seed, folium cortex eucommiae, honey-fried licorice root, yam rhizome, benzoin, Chinese ladybell root, poria with hostwood and pinellia ternate in the formula at the temperature of minus 15 ℃ to minus 20 ℃, and breaking the cell wall of the raw material medicine by a wall breaking machine to expose the effective components in the cell;
2) extraction and purification: putting the peach kernels, poria cocos, allium macrostemon, cinnamon, cortex albiziae, radix pseudostellariae, platycladi seeds, folium cortex eucommiae, honey-fried licorice roots, rhizoma dioscoreae, benzoin, Chinese ladybell roots, poria cocos and pinellia ternate which are subjected to wall breaking in the step 1) into an extraction kettle, adding 20% ethanol which is 8-10 times of the weight of the wall breaking raw materials, extracting for 3-5 hours, and filtering to obtain filtrate;
3) evaporating the filtrate and concentrating to obtain soft extract;
4) adding adjuvants into the extract, stirring, drying, pulverizing into 100 mesh fine powder, and making into clinically acceptable dosage forms by conventional method.
As another embodiment of the scheme, the peach kernel, the poria cocos, the allium macrostemon, the cinnamon, the cortex albiziae, the radix pseudostellariae, the semen boitae, the folium cortex eucommiae, the honey-fried licorice root, the rhizoma dioscoreae, the benzoin, the radix salviae miltiorrhizae, the poria cocos and the pinellia ternate after wall breaking are treated for 3 times in the step 2), and the filtrates obtained after 3 times are combined; the dosage form in the step 4) is any one of tablets and pills.
Specific examples and comparative examples are listed below:
example 1:
the medicine for treating heart disease comprises the following raw material medicines in parts by weight:
a preparation method of a medicine for treating heart disease comprises the following steps:
1) and (3) breaking the wall at low temperature: setting the raw materials of peach kernel, tuckahoe, allium macrostemon, cinnamon, cortex albiziae, radix pseudostellariae, platycladi seed, folium cortex eucommiae, honey-fried licorice root, yam rhizome, benzoin, Chinese ladybell root, poria with hostwood and pinellia ternate in the formula at the temperature of minus 15 ℃ to minus 20 ℃, and breaking the cell wall of the raw material medicine by a wall breaking machine to expose the effective components in the cell;
2) extraction and purification: putting the peach kernels, poria cocos, allium macrostemon, cinnamon, cortex albiziae, radix pseudostellariae, platycladi seeds, folium cortex eucommiae, honey-fried licorice roots, rhizoma dioscoreae, benzoin, Chinese ladybell roots, poria cocos and pinellia ternate which are subjected to wall breaking in the step 1) into an extraction kettle, adding 20% ethanol which is 8 times of the weight of the wall breaking raw materials to extract for 3 hours, filtering, extracting and purifying filter residues for 2 times, and combining filtrates obtained in three times;
3) evaporating the filtrate and concentrating to obtain soft extract;
4) adding adjuvants into the extract, stirring, drying, pulverizing into 100 mesh fine powder, and making into pill by conventional method.
Example 2:
the medicine for treating heart disease comprises the following raw material medicines in parts by weight:
a preparation method of a medicine for treating heart disease comprises the following steps:
1) and (3) breaking the wall at low temperature: setting the raw materials of peach kernel, tuckahoe, allium macrostemon, cinnamon, cortex albiziae, radix pseudostellariae, platycladi seed, folium cortex eucommiae, honey-fried licorice root, yam rhizome, benzoin, Chinese ladybell root, poria with hostwood and pinellia ternate in the formula at-18 ℃, and breaking the cell wall of the raw material medicine by a wall breaking machine to expose the effective components in the cell;
2) extraction and purification: putting the peach kernels, poria cocos, allium macrostemon, cinnamon, cortex albiziae, radix pseudostellariae, platycladi seeds, folium cortex eucommiae, honey-fried licorice roots, rhizoma dioscoreae grandiflorum, benzoin, Chinese ladybell roots, poria cocos and pinellia ternate subjected to wall breaking in the step 1) into an extraction kettle, adding 20% ethanol which is 9 times of the weight of the wall breaking raw materials, extracting for 3-5 hours, filtering, extracting and purifying filter residues for 2 times, and combining filtrates of the three times;
3) evaporating the filtrate and concentrating to obtain soft extract;
4) adding adjuvants into the extract, stirring, drying, pulverizing into 100 mesh fine powder, and making into pill by conventional method.
Example 3:
the medicine for treating heart disease comprises the following raw material medicines in parts by weight:
a preparation method of a medicine for treating heart disease comprises the following steps:
1) and (3) breaking the wall at low temperature: setting the raw materials of peach kernel, tuckahoe, allium macrostemon, cinnamon, cortex albiziae, radix pseudostellariae, platycladi seed, folium cortex eucommiae, honey-fried licorice root, yam rhizome, benzoin, Chinese ladybell root, poria with hostwood and pinellia ternate in the formula at-20 ℃, and breaking the cell wall of the raw material medicine by a wall breaking machine to expose the effective components in the cell;
2) extraction and purification: putting the peach kernels, poria cocos, allium macrostemon, cinnamon, cortex albiziae, radix pseudostellariae, platycladi seeds, folium cortex eucommiae, honey-fried licorice roots, rhizoma dioscoreae grandiflorum, benzoin, Chinese ladybell roots, poria cocos and pinellia ternate subjected to wall breaking in the step 1) into an extraction kettle, adding ethanol with the mass concentration of 20% and the weight which is 10 times that of the wall breaking raw materials into the extraction kettle, extracting for 3-5 hours, filtering, extracting and purifying filter residues for 2 times, and combining filtrates obtained in three times;
3) evaporating the filtrate and concentrating to obtain soft extract;
4) adding adjuvants into the extract, stirring, drying, pulverizing into 100 mesh fine powder, and making into pill by conventional method.
Comparative example 1:
the medicine for treating heart disease comprises the following raw material medicines in parts by weight:
a preparation method of a medicine for treating heart disease comprises the following steps:
1) and (3) breaking the wall at low temperature: setting the raw materials of peach kernel, tuckahoe, allium macrostemon, cortex albiziae, radix pseudostellariae, platycladi seed, folium cortex eucommiae, honey-fried licorice root, yam, benzoin, Chinese ladybell root, poria with hostwood and pinellia ternate in the formula at the temperature of minus 15 ℃ to minus 20 ℃, and breaking the cell wall of the raw material medicine by a wall breaking machine to expose the effective components in the cell;
2) extraction and purification: putting the peach kernels, the poria cocos, the allium macrostemon, the cortex albiziae, the radix pseudostellariae, the semen boitae, the folium cortex eucommiae, the radix glycyrrhizae preparata, the rhizoma dioscoreae, the benzoin, the radix salviae miltiorrhizae, the poria cocos and the pinellia ternate which are subjected to wall breaking in the step 1) into an extraction kettle, adding ethanol with the mass concentration of 20% and the weight which is 8 times that of the wall breaking raw materials into the extraction kettle for extraction for 3 hours, filtering the extraction kettle, extracting and purifying filter residues for 2 times again;
3) evaporating the filtrate and concentrating to obtain soft extract;
4) adding adjuvants into the extract, stirring, drying, pulverizing into 100 mesh fine powder, and making into pill by conventional method.
Comparative example 2:
the medicine for treating heart disease comprises the following raw material medicines in parts by weight:
a preparation method of a medicine for treating heart disease comprises the following steps:
1) and (3) breaking the wall at low temperature: setting the raw materials of peach kernel, tuckahoe, allium macrostemon, cinnamon, cortex albiziae, platycladi seed, eucommia leaf, honey-fried licorice root, yam, benzoin, Chinese ladybell root, poria with hostwood and pinellia tuber in the formula at the temperature of minus 15 ℃ to minus 20 ℃, and breaking the cell wall of the raw material medicine by a wall breaking machine to expose the effective components in the cell;
2) extraction and purification: putting the peach kernels, the poria cocos, the allium macrostemon, the cinnamon, the cortex albiziae, the platycladi seeds, the eucommia leaves, the honey-fried licorice roots, the rhizoma dioscoreae, the benzoin, the Chinese ladybell roots, the poria cocos and the pinellia ternate which are subjected to wall breaking in the step 1) into an extraction kettle, adding ethanol with the mass concentration of 20% and the weight which is 8 times that of the wall breaking raw materials into the extraction kettle for extraction for 3 hours, filtering the extraction kettle, extracting and purifying filter residues for 2 times again, and combining filtrates of the three times;
3) evaporating the filtrate and concentrating to obtain soft extract;
4) adding adjuvants into the extract, stirring, drying, pulverizing into 100 mesh fine powder, and making into pill by conventional method.
Comparative example 3:
the medicine for treating heart disease comprises the following raw material medicines in parts by weight:
a preparation method of a medicine for treating heart disease comprises the following steps:
1) and (3) breaking the wall at low temperature: setting the raw materials of peach kernel, tuckahoe, allium macrostemon, cinnamon, cortex albiziae, radix pseudostellariae, folium cortex eucommiae, honey-fried licorice root, yam, benzoin, Chinese ladybell root, poria with hostwood and pinellia ternate in the formula at-18 ℃, and breaking the cell wall of the raw materials by a wall breaking machine to expose the effective components in the cells;
2) extraction and purification: putting the peach kernels, poria cocos, allium macrostemon, cinnamon, cortex albiziae, radix pseudostellariae, folium cortex eucommiae, radix glycyrrhizae preparata, rhizoma dioscoreae, benzoin, Chinese ladybell root, poria cocos and pinellia ternate which are subjected to wall breaking in the step 1) into an extraction kettle, adding ethanol with the mass concentration of 20% and the weight 9 times that of the wall-breaking raw materials into the extraction kettle for extraction for 3-5 hours, filtering, extracting and purifying filter residues for 2 times, and combining filtrates obtained in three times;
3) evaporating the filtrate and concentrating to obtain soft extract;
4) adding adjuvants into the extract, stirring, drying, pulverizing into 100 mesh fine powder, and making into pill by conventional method.
Comparative example 4:
the medicine for treating heart disease comprises the following raw material medicines in parts by weight:
a preparation method of a medicine for treating heart disease comprises the following steps:
1) and (3) breaking the wall at low temperature: setting the raw materials of peach kernel, tuckahoe, allium macrostemon, cinnamon, cortex albiziae, radix pseudostellariae, platycladi seed, folium cortex eucommiae, dioscorea bulbifera, benzoin, Chinese ladybell root, poria with hostwood and pinellia ternate in the formula at-18 ℃, and breaking the cell wall of the raw material medicines by a wall breaking machine to expose the effective components in the cells;
2) extraction and purification: putting the peach kernels, poria cocos, allium macrostemon, cinnamon, cortex albiziae, radix pseudostellariae, platycladi seeds, folium cortex eucommiae, rhizoma dioscoreae hypoglaucae, benzoin, Chinese ladybell roots, poria cocos and pinellia ternate subjected to wall breaking in the step 1) into an extraction kettle, adding ethanol with the mass concentration of 20% and the weight 9 times that of the wall-breaking raw materials into the extraction kettle, extracting the mixture for 3-5 hours, filtering the mixture, extracting and purifying filter residues for 2 times again, and combining the filtrates obtained in the three times;
3) evaporating the filtrate and concentrating to obtain soft extract;
4) adding adjuvants into the extract, stirring, drying, pulverizing into 100 mesh fine powder, and making into pill by conventional method.
Comparative example 5:
the medicine for treating heart disease comprises the following raw material medicines in parts by weight:
a preparation method of a medicine for treating heart disease comprises the following steps:
1) and (3) breaking the wall at low temperature: setting the raw materials of peach kernel, tuckahoe, allium macrostemon, cinnamon, cortex albiziae, radix pseudostellariae, platycladi seed, folium cortex eucommiae, honey-fried licorice root, benzoin, Chinese ladybell root, poria with hostwood and pinellia ternate in the formula at-20 ℃, and breaking the cell wall of the raw materials by a wall breaking machine to expose the effective components in the cells;
2) extraction and purification: putting the peach kernels, poria cocos, allium macrostemon, cinnamon, cortex albiziae, radix pseudostellariae, platycladi seeds, folium cortex eucommiae, honey-fried licorice roots, benzoin, Chinese ladybell roots, poria cocos and pinellia ternate which are subjected to wall breaking in the step 1) into an extraction kettle, adding ethanol with the mass concentration of 20% and the weight which is 10 times that of the wall breaking raw materials into the extraction kettle, extracting for 3-5 hours, filtering, extracting and purifying filter residues for 2 times, and combining filtrates obtained in three times;
3) evaporating the filtrate and concentrating to obtain soft extract;
4) adding adjuvants into the extract, stirring, drying, pulverizing into 100 mesh fine powder, and making into pill by conventional method.
Comparative example 6:
the medicine for treating heart disease comprises the following raw material medicines in parts by weight:
a preparation method of a medicine for treating heart disease comprises the following steps:
1) and (3) breaking the wall at low temperature: setting the raw materials of peach kernel, tuckahoe, allium macrostemon, cinnamon, cortex albiziae, radix pseudostellariae, platycladi seed, folium cortex eucommiae, honey-fried licorice root, yam rhizome, Chinese ladybell root, poria with hostwood and pinellia ternate in the formula at-20 ℃, and breaking the cell wall of the raw materials by a wall breaking machine to expose the effective components in the cells;
2) extraction and purification: putting the peach kernels, poria cocos, allium macrostemon, cinnamon, cortex albiziae, radix pseudostellariae, platycladi seeds, folium cortex eucommiae, honey-fried licorice roots, rhizoma dioscoreae, Chinese ladybell roots, poria cocos and pinellia ternate subjected to wall breaking in the step 1) into an extraction kettle, adding ethanol with the mass concentration of 20% and the weight which is 10 times that of the wall breaking raw materials into the extraction kettle, extracting for 3-5 hours, filtering, extracting and purifying the filter residues for 2 times, and combining the filtrates obtained in three times;
3) evaporating the filtrate and concentrating to obtain soft extract;
4) adding adjuvants into the extract, stirring, drying, pulverizing into 100 mesh fine powder, and making into pill by conventional method.
Comparative example 7:
the medicine for treating heart disease comprises the following raw material medicines in parts by weight:
a preparation method of a medicine for treating heart disease comprises the following steps:
1) and (3) breaking the wall at low temperature: setting the raw materials of peach kernel, tuckahoe, allium macrostemon, cinnamon, cortex albiziae, radix pseudostellariae, platycladi seed, folium cortex eucommiae, honey-fried licorice root, yam rhizome, benzoin, Chinese ladybell root, poria with hostwood and pinellia ternate in the formula at-20 ℃, and breaking the cell wall of the raw material medicine by a wall breaking machine to expose the effective components in the cell;
2) extraction and purification: putting the peach kernels, poria cocos, allium macrostemon, cinnamon, cortex albiziae, radix pseudostellariae, platycladi seeds, folium cortex eucommiae, honey-fried licorice roots, rhizoma dioscoreae grandiflorum, benzoin, Chinese ladybell roots, poria cocos and pinellia ternate subjected to wall breaking in the step 1) into an extraction kettle, adding ethanol with the mass concentration of 20% and the weight which is 10 times that of the wall breaking raw materials into the extraction kettle, extracting for 3-5 hours, filtering, extracting and purifying filter residues for 2 times, and combining filtrates obtained in three times;
3) evaporating the filtrate and concentrating to obtain soft extract;
4) adding adjuvants into the extract, stirring, drying, pulverizing into 100 mesh fine powder, and making into pill by conventional method.
Comparative example 8:
the medicine for treating heart disease comprises the following raw material medicines in parts by weight:
a preparation method of a medicine for treating heart disease comprises the following steps:
1) and (3) breaking the wall at low temperature: setting the raw materials of peach kernel, tuckahoe, allium macrostemon, cinnamon, cortex albiziae, radix pseudostellariae, platycladi seed, folium cortex eucommiae, honey-fried licorice root, yam rhizome, benzoin, poria with hostwood and pinellia ternate in the formula at-20 ℃, and breaking the cell wall of the raw materials by a wall breaking machine to expose the effective components in the cell;
2) extraction and purification: putting the peach kernels, poria cocos, allium macrostemon, cinnamon, cortex albiziae, radix pseudostellariae, platycladi seeds, folium cortex eucommiae, honey-fried licorice roots, rhizoma dioscoreae, benzoin, poria with hostwood and pinellia ternate subjected to wall breaking in the step 1) into an extraction kettle, adding ethanol with the mass concentration of 20% and the weight which is 10 times that of the wall-breaking raw materials into the extraction kettle for extraction for 3-5 hours, filtering, extracting and purifying filter residues for 2 times, and combining filtrates obtained in three times;
3) evaporating the filtrate and concentrating to obtain soft extract;
4) adding adjuvants into the extract, stirring, drying, pulverizing into 100 mesh fine powder, and making into pill by conventional method.
Comparative example 8:
the medicine for treating heart disease comprises the following raw material medicines in parts by weight:
a preparation method of a medicine for treating heart disease comprises the following steps:
1) and (3) breaking the wall at low temperature: setting the raw materials of peach kernel, tuckahoe, allium macrostemon, cinnamon, cortex albiziae, radix pseudostellariae, platycladi seed, folium cortex eucommiae, radix glycyrrhizae preparata, dioscorea panthaica, benzoin, Chinese ladybell root and pinellia ternate in the formula at-20 ℃, and breaking the cell wall of the raw materials by a wall breaking machine to expose the effective components in the cells;
2) extraction and purification: putting the peach kernels, poria cocos, allium macrostemon, cinnamon, cortex albiziae, radix pseudostellariae, platycladi seeds, folium cortex eucommiae, honey-fried licorice roots, rhizoma dioscoreae, benzoin, Chinese ladybell roots and pinellia ternate subjected to wall breaking in the step 1) into an extraction kettle, adding ethanol with the mass concentration of 20% and the weight which is 10 times that of the wall-breaking raw materials into the extraction kettle for extraction for 3-5 hours, filtering, extracting and purifying filter residues for 2 times, and combining filtrates obtained in three times;
3) evaporating the filtrate and concentrating to obtain soft extract;
4) adding adjuvants into the extract, stirring, drying, pulverizing into 100 mesh fine powder, and making into pill by conventional method.
Test example:
in order to further investigate the curative effect of the medicament, 330 patients with heart diseases such as angina pectoris, myocardial infarction and coronary heart disease are clinically tested and researched, the reaction is good, no obvious toxic or side effect exists, and the statistics of clinical tests are as follows:
(1) the source of the patient: 550 patients with heart diseases such as angina pectoris, myocardial infarction and coronary heart disease are selected in a hospital in the city, wherein 350 male patients and 200 female patients are 200 female patients, the average age is 42.6 years old, all the patients voluntarily receive clinical studies, and 50 patients are not treated by other medicines in the treatment process.
(2) Dosage and method of administration: the traditional Chinese medicine pill for treating heart disease is taken 3 times a day, 9g is taken each time, one month is 1 course of treatment, and the pill is continuously used for 2 months.
(3) Clinical efficacy evaluation criteria:
remarkably: the symptoms of angina pectoris, myocardial infarction, coronary heart disease and other heart diseases disappear;
the method has the following advantages: relieving symptoms of heart diseases such as angina pectoris, myocardial infarction, coronary heart disease, etc.;
and (4) invalidation: the symptoms of the heart diseases such as angina pectoris, myocardial infarction, coronary heart disease and the like are not obviously improved or ineffective.
The therapeutic effect is shown in table 1:
from the results in table 1, it can be seen that after patients diagnosed with heart diseases such as angina pectoris, myocardial infarction and coronary heart disease continuously take the capsules for treating heart diseases of embodiments 1 to 3 of the present invention for 60 days, the significant rate is more than 80%, the effective rate is more than 8%, and the ineffective rate is less than 4%. Compared with the treatment effects of the embodiments 1 to 3, the treatment effects of the comparative examples 1 to 8 are poor, the raw materials for treating the heart disease are reasonably compatible, the unique performance and efficacy of the raw materials are fully exerted, the complementary action among the raw materials is considered, the drug effects complement each other, the treatment effect of the heart disease is remarkable, no toxic or side effect exists, and the problem of poor treatment effect of treating the heart disease is solved.
While embodiments of the invention have been disclosed above, it is not limited to the applications listed in the description and the embodiments, which are fully applicable in all kinds of fields of application of the invention, and further modifications may readily be effected by those skilled in the art, so that the invention is not limited to the specific details without departing from the general concept defined by the claims and the scope of equivalents.
Claims (10)
1. The medicine for treating heart disease is characterized by comprising the following raw material medicines in parts by weight:
2. the drug for treating heart disease according to claim 1, further comprising 2 to 4 parts by weight of platycladi seed.
3. The drug for treating heart disease according to claim 1, further comprising 0.5 to 2 parts by weight of eucommia ulmoides leaves.
4. The drug for treating heart disease according to claim 1, further comprising 1-3 parts by weight of honey-fried licorice root.
5. The drug for treating heart disease as recited in claim 1, further comprising 4-6 parts by weight of Guangdong yam.
6. The drug for treating heart disease according to claim 1, further comprising 1 to 3 parts by weight of benzoin.
7. The drug for treating heart disease according to claim 1, further comprising 3 to 5 parts by weight of discorea.
8. The drug for treating heart disease as claimed in claim 1, further comprising 0.5-2 parts by weight of poria with hostwood and 2-5 parts by weight of pinellia ternate.
9. The method for preparing a medicament for treating heart disease according to any one of claims 1 to 8, comprising the steps of:
1) and (3) breaking the wall at low temperature: setting the raw materials of peach kernel, tuckahoe, allium macrostemon, cinnamon, cortex albiziae, radix pseudostellariae, platycladi seed, folium cortex eucommiae, honey-fried licorice root, yam rhizome, benzoin, Chinese ladybell root, poria with hostwood and pinellia ternate in the formula at the temperature of minus 15 ℃ to minus 20 ℃, and breaking the cell wall of the raw material medicine by a wall breaking machine to expose the effective components in the cell;
2) extraction and purification: putting the peach kernels, poria cocos, allium macrostemon, cinnamon, cortex albiziae, radix pseudostellariae, platycladi seeds, folium cortex eucommiae, honey-fried licorice roots, rhizoma dioscoreae, benzoin, Chinese ladybell roots, poria cocos and pinellia ternate which are subjected to wall breaking in the step 1) into an extraction kettle, adding 20% ethanol which is 8-10 times of the weight of the wall breaking raw materials, extracting for 3-5 hours, and filtering to obtain filtrate;
3) evaporating the filtrate and concentrating to obtain soft extract;
4) adding adjuvants into the extract, stirring, drying, pulverizing into 100 mesh fine powder, and making into clinically acceptable dosage forms by conventional method.
10. The method for preparing a medicine for treating heart disease according to claim 9, wherein the wall-broken peach kernels, poria cocos, allium macrostemon, cinnamon, cortex albiziae, radix pseudostellariae, platycladi seeds, folium cortex eucommiae, honey-fried licorice roots, guan-yu-han, benzoin, Chinese ladybell roots, poria with hostwood and pinellia ternate are treated for 3 times in the step 2), and the filtrates obtained for 3 times are combined; the dosage form in the step 4) is any one of tablets and pills.
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| Title |
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| 周德生等: "《常用中药特殊配伍精要》", 31 October 2007, 山西科学技术出版社 * |
| 林中堂中药有限公司: "林中堂火系"五方"桃仁茯苓颗粒", 《HTTP://WWW.LINZHONGTANG.COM/SHOW.ASP?ID=35》 * |
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