WO2015149391A1 - Preparation of traditional chinese medicine for treating chronic enteritis and preparation method therefor - Google Patents
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- WO2015149391A1 WO2015149391A1 PCT/CN2014/075338 CN2014075338W WO2015149391A1 WO 2015149391 A1 WO2015149391 A1 WO 2015149391A1 CN 2014075338 W CN2014075338 W CN 2014075338W WO 2015149391 A1 WO2015149391 A1 WO 2015149391A1
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Definitions
- the invention relates to a traditional Chinese medicine preparation for treating enteritis, in particular to a traditional Chinese medicine preparation for treating chronic enteritis and a preparation method thereof.
- the intestine refers to the digestive tract from the pylorus of the stomach to the anus.
- the intestine is the longest part of the digestive tract and is the most important part of the function.
- the intestine is the largest digestive organ of the human body and the largest detoxification organ in the human body. From the perspective of physiology, anatomy, and cytology, large intestine detoxification accounts for more than 85 % of human detoxification; 80% of the human body's immune structure is around the intestine, and endotoxin accumulation is the killer of autoimmune immunity.
- Enteritis mainly refers to gastroenteritis, enteritis, and colitis, and is generally thought to be caused by bacteria, viruses, fungi, and parasites.
- the main clinical manifestations are nausea, vomiting, abdominal pain, diarrhea, bloody stools, and stools. Some patients may have fever and a feeling of urgency.
- the incidence of chronic enteritis is on the rise, and the course of the disease is long, difficult to cure, repeated attacks, seriously affecting people's health and quality of life, and The cancer rate is about 5%.
- the drugs currently used to treat enteritis are not small, Western medicines are not cured, and they are prone to drug resistance for a long time.
- the side effects are relatively large, which damages the liver, kidneys and blood cells, and the drug is unstable and easy to recur. Summary of the invention
- the object of the present invention is to provide a traditional Chinese medicine preparation for treating chronic enteritis on the basis of the above-mentioned deficiencies, combined with modern Chinese and Western medicine technology, and in particular to provide such a traditional Chinese medicine preparation and a preparation method thereof, the enteritis of the present invention
- the treatment effect is obvious, and it is non-toxic, has no side effects, and has stable effects, and the preparation process is simple and easy.
- the preparation of the invention is from cassia twig, codonopsis pilosula, dried ginger, ginseng ginseng, licorice, woody scent, oyster shell, longan nucleus, bergamot, chicken inner gold, orange peel, agarwood, angelica, maiden, calcined scorpion, yellow sage, large
- the preparation of the composition prepared by blood vine, white peony and jujube, wherein the mass ratio of each component is: cassia twig 12-20g: ginseng 10-22g dried ginger 8-18g ginseng ginseng 10-18g licorice 8-15g woody
- Astragalus 10-18g blood vine 8-16g white peony 8-15g jujube 10-20g (
- the preferred raw material quality ratio of the present invention is: Guizhi 12-18g Codonopsis 10-18g Dried ginger 8-12g Prince 12-18g Licorice 8-12g Woody
- the present invention is also preferable as a raw material cassia 15g Codonopsis 12g dried ginger 9g prince 15g licorice 10g woody 12g
- the above preparation method for treating a traditional Chinese medicine preparation for chronic enteritis comprises the following steps:
- Codonopsis in a small pot and stir fry until the surface is slightly coke, and then crushed by a pulverizer and passed through a 80 mesh sieve for use; Astragalus membranaceus and big blood vine are proportioned well, pulverized into powder by a pulverizer and passed through a 90 mesh sieve, and dried naturally for use;
- step 3 mix the powders of each component in step 1) and 2), add boiling water twice, add 10 times pure water for 1 hour, extract the filtrate for use; 6 times pure water decoction for half an hour, then combine the decoction and filter, spare;
- step 5 mixing the powders of each component in step 4), adding 4 to 6 times 70% ⁇ 80% ethanol, heating and refluxing for 3 to 5 hours, extracting and filtering to obtain a filtrate; and then remaining the dregs Adding 2 to 4 times of 65% to 75% ethanol again, heating and refluxing for 2 to 3 hours, extracting and filtering to obtain a filtrate; combining the filtrates obtained twice, removing the ethanol solvent under reduced pressure, and drying to obtain a dry paste. ;
- the dry paste obtained in the above step 5) is ultra-pulverized into a powder and passed through a 200 mesh sieve, and then the powder is added to 3) the combined decoction in the step, and the mixture is shaken to obtain.
- the prepared Chinese medicine composition solution preparation can be used for oral administration, and if it can be consumed once in the morning and evening, and it is used for a long time, the effect is better.
- the theoretical basis of the invention is: cassia twig, which is a dry twig of cinnamon of the evergreen tree plant of the family Aphididae, mainly produced in Guangxi, Guangdong and Yunnan. Cut the shoots in spring and summer, dry or dry, cut into thin slices or small sections.
- the taste of Xin Wen has the function of warming the veins, dispelling the cold, and treating the qi stagnation caused by insufficient yang Blood coagulation, abdominal pain, cold blood stasis, etc., can also treat colds caused by cold, cold, cough and other diseases have a good effect.
- the extract of osmanthus fragrans can inhibit Escherichia coli, Bacillus subtilis and Staphylococcus aureus in vitro, with an effective concentration of 25 mg/ml or less; against Staphylococcus aureus, Shigella dysenteriae, Typhoid fever and Parahaemolyticus, Pneumococcal , Azotobacter, Proteus, Bacillus anthracis, Salmonella enteritidis, Vibrio cholerae, etc. also have inhibitory effects. Codonopsis pilosula has anti-gastrointestinal mucosal damage, pharmacological effects related to Buzhong Yiqi and spleen-suppressing effects to adjust gastrointestinal motility and anti-ulcer.
- Dangshen has the functions of enhancing immune function, enhancing hematopoietic function, anti-stress, cardiotonic, anti-shock, regulating blood pressure, resisting myocardial ischemia and inhibiting platelet aggregation.
- Dangshen also has the functions of puzzle, calmness, hypnosis and anti-convulsion. Dangshen has the effect of replenishing vital energy, strengthening the spleen and benefiting the lungs. For spleen and lung weakness.
- Dried ginger is a dried ginger, spicy, hot, spleen, stomach, heart, lung. It has the effect of warming and dispelling cold, returning to Yangtongmai, warming lung and drinking. It is used for spleen and stomach yang deficiency and has a cold syndrome.
- Radix Pseudostellariae also known as ginseng
- ginseng is a kind of ginseng. It has a calming, sweet taste and a tonifying effect. It is often used for spleen and stomach weakness, lack of stomach yin, fatigue, indigestion, loss of appetite and so on.
- Licorice a kind of tonic Chinese herbal medicine, the medicinal parts are roots and rhizomes. The roots of the medicinal properties are cylindrical, with spleen and qi, clearing away heat and detoxification, relieving cough, relieving pain, and reconciling various medicines.
- Woody is the general name for the genus Yunmuxiang and Chuanmuxiang, and is the dry root of the woody scent of Compositae. Woody has an antibacterial effect, can inhibit the regeneration of gastrointestinal bacteria, and can also inhibit the reproduction of liver virus replication, and play a role in reducing inflammation and protecting the liver.
- Clam shell bitter taste, cool, into the lungs, spleen, large intestine, broken gas, sputum, elimination, treatment of chest stagnation, chest, bloating, food, belching, vomiting, diarrhea Heavy, rectal prolapse, uterine prolapse and other effects.
- Longan core, miso, qi and pain, hemostasis, moisture absorption, etc. can be used for hernia pain, traumatic bleeding, phlegm, wet sores and so on. Disperse wind and evil spirits, cure dizziness, deafness, and vertigo.
- bergamot also known as the five-finger orange, bergamot, its roots, stems, leaves, flowers, and fruit can be used as medicine, bitter, spicy, sweet, warm, into the liver, spleen, stomach, lung, rational gasification, coughing It has many medicinal functions such as swelling, soothing liver and strengthening spleen and gastrointestinal tract.
- Chenpi alias agarwood, spicy, bitter, warm; spleen, stomach, lung; qi scent, can be ascending or descending; Chenpi's bitter substance is represented by limonin and bitterin ", this kind of lemon bitter tastes calm, easy to dissolve in water, helps digestion of food; has the effect of qi and medium, dampness and phlegm, and water and laxative. Indications for spleen and stomach discomfort, abdominal pain, spleen and stomach weakness, loss of appetite, vomiting hiccups, limb weakness and other symptoms, and Codonopsis, dried ginger, yam equivalent, the effect is better.
- Angelica a perennial herb, distributed in Gansu, Yunnan, Sichuan, Qinghai, Shaanxi, Hunan, Hubei, Guizhou, etc., cultivated everywhere.
- the root of Angelica is one of the most commonly used Chinese medicines.
- Angelica has the effect of warming meridians, promoting blood circulation and relieving pain, whether it is cold and abdominal pain, or rheumatoid joint pain, or bruises and blood stasis. Angelica is also commonly used in hemorrhoids. Because Angelica activating blood circulation and dissipating blood stasis, it can reduce swelling and relieve pain and discharge pus muscle.
- the famous Fangfang Xiagging Live Drink for treating sores is equivalent to Angelica and Red Oak, Honeysuckle and Gunsan.
- Ophiopogon japonicus is a perennial evergreen grass plant of the genus Liliaceae. The fibrous roots are thicker and thicker.
- the top or middle part of the root is often expanded into a spindle-shaped succulent piece, which is used as a root. Slightly cold, taste It is slightly bitter and medicinal experiments have proved that Maimendong has the effect of increasing white blood cells, prolonging the existence time of antibodies, improving immune function and nucleic acid synthesis rate, and promoting the production of immune substances such as antibodies, complement, interferon and lysozyme. Therefore, Ophiopogon has the effect of strengthening the righteousness and strengthening the anti-evil effect, thereby reducing the incidence of disease. It is used for lung and stomach yin deficiency, less thirst, dry cough and hemoptysis, heart yin deficiency, heart irritability and fever, and late heat injury.
- Calcined scorpion sweet, flat, liver, lung, stomach. It has the effects of eliminating phlegm and dissipating phlegm, softening and firming, and acid-relieving pain. Mainly used for pantothenic acid, stubborn accumulation, sticky and difficult to embolize. Astragalus, Astragalus, alias Camellia root, earth tea root. For the plant of the Labiatae, the root is used as a medicine. It has heat and dampness, cool blood and fetus, detoxification effect.
- the clinical application of Astragalus is better than berberine and does not produce drug resistance. Big blood vine, bitter, flat.
- Jujube, sweet and warm, spleen and stomach rich in protein, fat, sugar, carotene, B vitamins, vitamin C, vitamin P and calcium, phosphorus, iron and cyclic adenosine monophosphate and other nutrients.
- the content of vitamin C is among the best in the fruit, and it has the reputation of vitamin king. It has the effect of replenishing vital energy, strengthening the spleen and stomach, nourishing blood and calming the nerves, and alleviating the medicinal properties. It is used for spleen deficiency, fatigue, and impotence.
- the pathogenesis is characterized by imaginary inclusion, so the above traditional Chinese medicine by the present invention
- the composition obtained by the compatibility and the preparation method can effectively achieve the effect of regulating the intestinal tract and the internal organs by using a dialectical method, has no toxic and side effects, and has stable effects, and achieves twice the result with half the effort with western medicine.
- the oral solution of the preparation of the present invention is taken half an hour after a meal, 3 times a day, 200 ml each time, 2 months for a course of treatment, and 3 courses of treatment as therapeutic effects.
- the oral solution of the preparation of the present invention is taken half an hour after a meal, 3 times a day, 200 ml each time, 2 months for a course of treatment, and 3 courses for observation of curative effect.
- the oral solution of the preparation of the present invention is taken half an hour after a meal, 3 times a day, 200 ml each time, 2 months for a course of treatment, and 3 courses for observation of curative effect.
- the preparation prepared by the invention has good effects for treating chronic enteritis, is non-toxic, has no side effects, has stable effects, and is simple and easy to prepare. Concrete real
- the preparation of the invention is from cassia twig, codonopsis pilosula, dried ginger, ginseng ginseng, licorice, woody scent, oyster shell, longan nucleus, bergamot, chicken inner gold, orange peel, agarwood, angelica, yoghurt, calcined scorpion, scutellaria, big blood
- a preparation preparation of vine, white peony and jujube, wherein the mass ratio of each component is Guizhi 12g Codonopsis 10g
- the above preparation method for treating a traditional Chinese medicine preparation for chronic enteritis comprises the following steps:
- Codonopsis in a small pot and stir fry until the surface is slightly coke, and then crushed by a pulverizer and passed through a 80 mesh sieve for use; Astragalus membranaceus and big blood vine are proportioned well, pulverized into powder by a pulverizer and passed through a 90 mesh sieve, and dried naturally for use;
- step 5 mixing the powders of each component in step 4), adding 4 to 6 times 70% ⁇ 80% ethanol, heating and refluxing for 3 to 5 hours, extracting and filtering to obtain a filtrate; and then remaining the dregs Adding 2 to 4 times of 65% to 75% ethanol again, heating and refluxing for 2 to 3 hours, extracting and filtering to obtain a filtrate; combining the filtrates obtained twice, removing the ethanol solvent under reduced pressure, and drying to obtain a dry paste. ;
- the dry paste obtained in the above step 5) is ultra-pulverized into a powder and passed through a 200 mesh sieve, and then the powder is added to the combined decoction in the step 3), and mixed and shaken to obtain.
- the preparation of the above-mentioned traditional Chinese medicine composition solution can be used for oral administration, and if it can be consumed once in the morning and evening and long-term drinking, the effect is better.
- the preferred raw material quality of the present invention is (g):
- the preparation method is as in Example 1.
- the preferred raw material quality of the present invention is (g):
- the preparation method is as in Example 1.
- the preferred raw material quality of the present invention is (g):
- the preparation method is as in Example 1.
- the preferred raw material quality of the present invention is (g):
- Codonopsis 18g Dried ginger 15g Radix Pseudostellariae 14g Licorice 15g Woody 18g Clam shell 15g Longan nucleus 18g Bergamot 14g Chicken inner gold 18g Tangerine 16g Agarwood 14g Angelica 12g Ophiopogon 13g Calcined scorpion Astragalus 18g Large blood vine 15g White peony 15g 18g
- the preparation method is as in Example 1.
- the preferred raw material quality of the present invention is (g):
- the preparation method is as in Example 1.
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Abstract
Preparation of traditional Chinese medicine for treating chronic enteritis and preparation method therefor, comprising Ramulus cinnamoni, Codonopsis pilosula, dried ginger, Pseudostellaria heterophylla, licorice, common vladimiria root, fructus aurantii, longan seed, Citrus medica sarcodactylis, Gallus gallus domesticus Brisson, pericarpium Citri reticulatae, Aquilaria agallocha, Angelica sinensis, Ophiopogon japonicus, calcined Arca inflata Reeve, Scutellaria baicalensis, Sargentodoxa cuneata, Bletilla striata and jujube, said ingredients being subjected to processes of powdering, decoction, ethanol extraction and mixing into a liquid preparation.
Description
一种治疗慢性肠炎的中药制剂及其制各方法 Traditional Chinese medicine preparation for treating chronic enteritis and preparation method thereof
技术领域 Technical field
本发明涉及一种治疗肠炎的中药制剂,具体涉及一种治疗慢性肠 炎的中药制剂及其制备方法。 背景技术 The invention relates to a traditional Chinese medicine preparation for treating enteritis, in particular to a traditional Chinese medicine preparation for treating chronic enteritis and a preparation method thereof. Background technique
肠指的是从胃幽门至肛门的消化管, 肠是消化管中最长的一段, 也是功能最重要的一段。肠道是人体最大的消化器官, 也是人体最大 的排毒器官。 从生理学、 解剖学、 细胞学的角度来看, 大肠排毒占人 体排毒的 85 %以上; 人体的 80 %免疫结构在肠道周围, 内毒素的堆积 是自体免疫力的杀手。 The intestine refers to the digestive tract from the pylorus of the stomach to the anus. The intestine is the longest part of the digestive tract and is the most important part of the function. The intestine is the largest digestive organ of the human body and the largest detoxification organ in the human body. From the perspective of physiology, anatomy, and cytology, large intestine detoxification accounts for more than 85 % of human detoxification; 80% of the human body's immune structure is around the intestine, and endotoxin accumulation is the killer of autoimmune immunity.
肠炎主要指胃肠炎、小肠炎和结肠炎,一般认为是由细菌、病毒、 真菌和寄生虫等引起。 临床主要表现有恶心、 呕吐、 腹痛、 腹泻、 大 便粘滞带血、 大便不成形, 部分病人可有发热及里急后重感觉。近年 来, 随着人们生活水平的提高和生活方式的改变, 慢性肠炎的发病率 呈上升趋势, 并且该病病程较长, 难以根治, 反复发作, 严重影响着 人们的身体健康和生活质量, 且癌变率达 5 %左右。 尽管目前用于治 疗肠炎的药物不算少, 但西药治标不治本, 用久了容易产生抗药性, 副作用比较大, 损害肝脏、 肾脏及血细胞, 而且药效不稳定, 容易反 复发作。
发明内容 Enteritis mainly refers to gastroenteritis, enteritis, and colitis, and is generally thought to be caused by bacteria, viruses, fungi, and parasites. The main clinical manifestations are nausea, vomiting, abdominal pain, diarrhea, bloody stools, and stools. Some patients may have fever and a feeling of urgency. In recent years, with the improvement of people's living standards and lifestyle changes, the incidence of chronic enteritis is on the rise, and the course of the disease is long, difficult to cure, repeated attacks, seriously affecting people's health and quality of life, and The cancer rate is about 5%. Although the drugs currently used to treat enteritis are not small, Western medicines are not cured, and they are prone to drug resistance for a long time. The side effects are relatively large, which damages the liver, kidneys and blood cells, and the drug is unstable and easy to recur. Summary of the invention
本发明的目的即在于针对上述不足, 在祖传秘方的基础上, 结合 现代中西医技术, 提供一种治疗慢性肠炎的中药制剂, 具体的说是提 供这种中药制剂及其制备方法,本发明肠炎治疗效果明显,而且无毒, 无副作用, 效果稳定, 制取工艺简便易行。 The object of the present invention is to provide a traditional Chinese medicine preparation for treating chronic enteritis on the basis of the above-mentioned deficiencies, combined with modern Chinese and Western medicine technology, and in particular to provide such a traditional Chinese medicine preparation and a preparation method thereof, the enteritis of the present invention The treatment effect is obvious, and it is non-toxic, has no side effects, and has stable effects, and the preparation process is simple and easy.
本发明的技术方案如下所述: The technical solution of the present invention is as follows:
本发明制剂是由桂枝、党参、干姜、太子参、甘草、木香、枳壳、 龙眼核、佛手、鸡内金、 陈皮、沉香、 当归、麦冬、煅瓦楞子、黄尊、 大血藤、白芨和大枣制备成的组合物制剂,其中各组分的质量配比为: 桂枝 12-20g :参 10-22g 干姜 8-18g 太子参 10-18g 甘草 8-15g 木香 The preparation of the invention is from cassia twig, codonopsis pilosula, dried ginger, ginseng ginseng, licorice, woody scent, oyster shell, longan nucleus, bergamot, chicken inner gold, orange peel, agarwood, angelica, maiden, calcined scorpion, yellow sage, large The preparation of the composition prepared by blood vine, white peony and jujube, wherein the mass ratio of each component is: cassia twig 12-20g: ginseng 10-22g dried ginger 8-18g ginseng ginseng 10-18g licorice 8-15g woody
10-20g 10-20g
m 8— 16g 龙眼核 12- 20g 佛手 m 8— 16g Longan Core 12- 20g Bergamot
8— 16g 8-16g
10-18g 10-18g
当归 8-15g 冬 6- 15g 煅瓦楞子 Angelica 8-15g winter 6- 15g calcined hazelnut
8-15g 8-15g
黄芩 10-18g :血藤 8-16g 白芨 8-15g 大枣 10-20g( Astragalus 10-18g: blood vine 8-16g white peony 8-15g jujube 10-20g (
为了获得更好的效果, 本发明可优选的原料质量配比为: 桂枝 12-18g 党参 10-18g 干姜 8-12g
太子 12— 18g 甘草 8-12g 木香In order to obtain better effects, the preferred raw material quality ratio of the present invention is: Guizhi 12-18g Codonopsis 10-18g Dried ginger 8-12g Prince 12-18g Licorice 8-12g Woody
10-15g 10-15g
枳壳 8-12g 艮核 12- 16g 佛手 8 - 12g 鸡内金 10-15g 陈皮 10-14g
Clam shell 8-12g 艮 core 12- 16g bergamot 8 - 12g chicken inner gold 10-15g orange peel 10-14g
10-15g 10-15g
当归 8-12g 麦冬 6-10g 煅瓦楞子 -12g Angelica 8-12g Ophiopogon 6-10g Calcined Corrugated Twelve -12g
黄芩 10-15g 血藤 8-12g 白芨 8 - 12g 大枣 12-18g。 Astragalus 10-15g blood vine 8-12g white peony 8 - 12g jujube 12-18g.
当然, 为了获得进一歩好的效果, 本发明还可优选的原料质 桂枝 15g 党参 12g 干姜 9g 太子 15g 甘草 10g 木香 12g Of course, in order to obtain a better effect, the present invention is also preferable as a raw material cassia 15g Codonopsis 12g dried ginger 9g prince 15g licorice 10g woody 12g
12g 龙眼核 10g 佛手 8g 鸡内金 12g 陈皮 14g 沉香 12g 当归 8g 麦冬 8g 煅瓦楞子 12g 黄芩 10g 大血藤 8g 白芨 10g 大枣 15g0 12g Longan core 10g Bergamot 8g Chicken inner gold 12g Chenpi 14g Agarwood 12g Angelica 8g Ophiopogon 8g Calcined wolfberry 12g Astragalus 10g Big blood vine 8g White peony 10g Jujube 15g 0
上述治疗慢性肠炎中药制剂的制备方法, 包括如下歩骤: The above preparation method for treating a traditional Chinese medicine preparation for chronic enteritis comprises the following steps:
1 )、 将党参放入小锅进行小炒至表面微焦, 然后经粉碎机粉碎并 过 80目筛, 备用;
黄芩、 大血藤按比例配好, 经过粉碎机粉碎成粉末并过 90 目筛, 自 然晾干, 备用; 1), put the Codonopsis in a small pot and stir fry until the surface is slightly coke, and then crushed by a pulverizer and passed through a 80 mesh sieve for use; Astragalus membranaceus and big blood vine are proportioned well, pulverized into powder by a pulverizer and passed through a 90 mesh sieve, and dried naturally for use;
3 )、 将歩骤 1 ) 和 2 ) 中的各组分粉末混合在一起, 加入纯净水 煎煮两次, 第一次加入 10倍纯净水煎煮 1小时, 提取滤液备用; 第 二次加入 6倍纯净水煎煮半小时, 然后合并煎液并过滤, 备用; 3), mix the powders of each component in step 1) and 2), add boiling water twice, add 10 times pure water for 1 hour, extract the filtrate for use; 6 times pure water decoction for half an hour, then combine the decoction and filter, spare;
4 )、 将剩下的木香、 鸡内金、 陈皮、 沉香、 当归、 麦冬、 煅瓦楞 子、 白芨按比例配好, 经过粉碎机粉碎成粉末并过 80 目筛, 自然晾 干, 备用; 4), the remaining woody, chicken gold, dried tangerine peel, agarwood, angelica, Ophiopogon japonicus, calyx scorpion, white peony proportioned well, pulverized into a powder by a pulverizer and passed through a 80 mesh sieve, naturally dried, spare ;
5 )、 将歩骤 4) 中各组分粉末混合在一起, 加入 4〜6倍70%〜80% 的乙醇, 加热回流 3〜5个小时, 提取过滤获得滤液; 然后在剩下的药 渣中再次加入 2〜4倍65%〜75%的乙醇, 加热回流 2〜3个小时, 提取过 滤获得滤液;将两次获得的滤液合并在一起,减压浓缩除去乙醇溶剂, 干燥, 获得干膏; 5), mixing the powders of each component in step 4), adding 4 to 6 times 70%~80% ethanol, heating and refluxing for 3 to 5 hours, extracting and filtering to obtain a filtrate; and then remaining the dregs Adding 2 to 4 times of 65% to 75% ethanol again, heating and refluxing for 2 to 3 hours, extracting and filtering to obtain a filtrate; combining the filtrates obtained twice, removing the ethanol solvent under reduced pressure, and drying to obtain a dry paste. ;
6 )、 将上述歩骤 5 ) 中获得的干膏进行超微粉碎成粉末并过 200 目筛, 然后将粉末加入 3 ) 歩骤中的合并煎液, 混合摇匀即可制得。 6), the dry paste obtained in the above step 5) is ultra-pulverized into a powder and passed through a 200 mesh sieve, and then the powder is added to 3) the combined decoction in the step, and the mixture is shaken to obtain.
制取的上述中药组合物溶液制剂可以用于口服,如果能够早中晚 各适量饮用一次并长期饮用, 效果更好。 本发明的理论依据在于: 桂枝, 为樟科常绿乔木植物肉桂的干燥嫩枝, 主产于广西、 广东 及云南等地。 春、 夏季剪下嫩枝, 晒干或阴干, 切成薄片或小段用。 行味辛温, 有温经通脉, 散寒解表的作用, 治疗阳气不足引起的气滞
血凝, 脘腹冷痛, 血寒经闭等症, 也可治疗因受冷引起的风寒感冒, 流涕咳嗽等病有很好的作用。桂枝醇提物在体外能抑制大肠杆菌、枯 草杆菌及金黄色葡萄球菌, 有效浓度为 25毫克 /毫升或以下; 对白色 葡萄球菌、 志贺氏痢疾杆菌、 伤寒和副伤寒甲杆菌、 肺炎球菌、 产气 杆菌、 变形杆菌、 炭疽杆菌、 肠炎沙门氏菌、 霍乱弧菌等亦有抑制作 用。 党参, 有抗胃肠黏膜损伤作用, 补中益气、 健脾功效相关的药理 作用为调整胃肠运动功能、 抗溃疡。 具有增强机体免疫功能、 增强造 血功能、 抗应激、 强心、 抗休克、 调节血压、 抗心肌缺血和抑制血小 板聚集等作用。 党参还具有益智、 镇静、 催眠、 抗惊厥等作用。 党参 具有补中益气, 健脾益肺的功效。 用于脾肺虚弱等。 干姜, 是生姜的干品, 味辛, 性热, 归脾、 胃、 心、 肺经。 具有 温中散寒,回阳通脉,温肺化饮的功效,用于脾胃阳虚而出现里寒证, 症见积食不消, 呕吐清水, 大便稀, 腹冷痛, 舌淡苔白, 脉沉细等。 太子参, 太子参又称为童参, 是人参的一种, 药性平和、 味甘, 有补气生津的作用, 常用于脾胃虚弱, 胃阴不足, 倦怠乏力、 消化不 良, 食欲不振等。 甘草, 是一种补益中草药, 药用部位是根及根茎, 药材性状根呈 圆柱形, 具有补脾益气, 清热解毒, 祛痰止咳, 缓急止痛, 调和诸药
的作用; 用于脾胃虚弱, 倦怠乏力, 心悸气短, 咳嗽痰多, 脘腹、 四 肢挛急疼痛, 痈肿疮毒, 缓解药物毒性、 烈性。 木香, 是菊科植物云木香和川木香的通称,是菊科植物木香的干燥 根。 木香有抗菌作用, 能够抑制胃肠细菌的再生, 还能抑制肝脏病毒的 复制的繁殖, 起到消炎护肝的作用。 枳壳, 性味苦辛、凉, 入肺、脾、大肠经, 有破气, 行痰, 消积、 治胸膈痰滞、 胸痞、 胁胀、 食、 噫气、 呕逆、 下痢后重, 脱肛, 子宫 脱垂等功效。 龙眼核, 味涩、 有理气止痛、 止血、 收湿等功效, 可用于疝气疼 痛、外伤出血、疥癣、湿疮等。散风邪风, 治心虚头暈、耳聋、眼花。 温肾利尿, 止血, 定痛, 理气, 化湿; 主治氕脏邪气, 治厌食、 食欲 不振, 驱肠叶寄生虫及血吸虫。 长期食用, 强体魄, 延年益寿, 安神 健脑长智慧, 开胃健脾, 补体虚。 佛手, 又名五指橘, 佛手柑, 其根、 茎、 叶、 花、 果均可入药, 味苦、 辛、 甘、 温, 入肝、 脾、 胃、 肺经, 有理气化痰, 止咳消胀、 舒肝健脾和胃肠等多种药用功能, 有疏肝解郁、 燥湿化痰、 理气和中 的功效, 常用于肝郁气滞、 脾胃气滞和痰湿壅肺等症。 鸡内金, 味甘性平, 入脾胃膀胱经, 含胃激素、 微量胃蛋白酶, 淀粉酶、 多种维生素, 有增加胃液分泌量和胃肠消化能力, 加快胃肠
的排空速率等作用, 有健胃消食, 固精止遗、 化石通淋之功能, 且能 健运脾胃, 可治饮食积滞, 为健胃消食之良药。 陈皮, 别名沉香, 味辛、苦, 性温; 归脾、 胃、肺经; 气香宣散, 可升可降; 陈皮的苦味物质是以柠檬苷和苦味素为代表的 "类柠檬苦 素" , 这种类柠檬苦素味平和, 易溶解于水, 有助于食物的消化; 具 有理气和中,燥湿化痰,利水通便的功效。主治脾胃不和、脘腹胀痛、 脾胃虚弱、 食欲不振、 呕吐哕逆、 肢倦无力等症, 和党参、 干姜、 山 药等同用, 效果较好。 沉香, 性味辛、 苦, 微温, 归脾、 胃、 肾经, 具有行气止痛, 温 中止呕, 暖肾纳气等功效, 主治呕吐呃逆, 脘腹胀痛, 腰膝虚冷, 大 肠虚秘, 胸腹胀闷疼痛, 胃寒呕吐呃逆, 肾虚气逆喘急等。 当归, 多年生草本植物,分布于甘肃、云南、 四川、青海、陕西、 湖南、 湖北、 贵州等地, 各地均有栽培。 当归的根可入药, 是最常用 的中药之一。 当归有温通经脉、 活血止痛的功效, 无论虚寒腹痛, 或 风湿关节疼痛, 或跌打损伤瘀血阻滞疼痛, 都可使用当归。 当归也常 用于痈疽疮疡。 因为当归活血化瘀, 能起到消肿止痛、 排脓生肌的功 效。 治疗疮疡的名方仙方活命饮, 就以当归与赤芍、 金银花、 炮山甲 等同用。 麦冬, 为百合科沿阶草属多年生常绿草本植物, 须根较粗壮, 根 的顶端或中部常膨大成为纺锤状肉质小块, 以块根入药。 性微寒,味
甘微苦,药理实验证明,麦门冬有升高白细胞,延长抗体存在时间的作 用,提高免疫功能和核酸合成率,促进抗体、 补体、 干扰素、 溶菌酶等 免疫物质产生。 因此麦冬有增强正气、 加强抗邪作用,从而减少疾病 的产生。 用于肺胃阴虚之津少口渴、 干咳咯血、 心阴不足之心悸易惊及 热病后期热伤津液等症。 煅瓦楞子, 味甘、 性平, 归肝、 肺、 胃经。 具有消痰化瘀, 软坚 散结, 制酸止痛的功效。 主要用于胃痛泛酸, 顽痰积结, 粘稠难咯等 症。 黄芩, 黄芩别名山茶根、 土金茶根。 为唇形科植物, 以根入药。 有 清热燥湿, 凉血安胎, 解毒功效。 主治温热病、 上呼吸道感染、 肺热咳 嗽、 湿热黄胆、 肺炎、 痢疾、 咳血、 目赤、 胎动不安、 高血压、 痈肿疖 疮等症。 黄芩的临床应用抗菌比黄连还好, 而且不产生抗药性。 大血藤, 味苦, 平。 归大肠、肝经。功能主治: 清热解毒, 活血, 祛风。 用于肠痈腹痛, 经闭痛经, 风湿痹痛, 跌扑肿痛。 具有败毒消 痈, 活血通络, 祛风杀虫的作用。 治急、 慢性阑尾炎, 风湿痹痛, 赤 痢, 血淋, 月经不调, 疳积, 虫痛, 跌扑损伤等症。 白芨, 性寒、 味苦、 甘、 涩, 无毒; 归肺、 胃、 肝经。 具有收敛止 血, 消肿生肌的功能。 主治肺痨略血, 吐血, 衄血, 便血, 外伤出血, 痈疮肿毒, 瘰疬, 痔漏, 烧烫伤, 手足皲裂, 肛裂等病症。 与本发明其 他中药配伍, 治疗肠炎效果明显。
大枣, 味甘性温, 归脾胃经, 富含蛋白质、 脂肪、 糖类、 胡萝卜 素、 B族维生素、 维生素 C、 维生素 P以及钙、 磷、 铁和环磷酸腺苷等 营养成分。其中维生素 C的含量在果品中名列前茅,有维生素王之美称。 具有补中益气,健脾益胃,养血安神,缓和药性的功效。用于脾虚食少, 乏力便溏, 妇人脏躁。 从我国传统中医角度讲, 慢性肠炎的病因病机, 有饮食不节, 戕 伤中州,或外邪内侵,损及脾胃,或忧患郁怒,肝失疏泄,横逆犯胃, 以及禀赋不足,脾胃虚弱等情形,其病表在 "肠" ,但与"胃"、 "脾" 、 "肝" 、 "肾"却关系密切, 病机特点是虚中夹实, 因此通过本发明 上述中药配伍以及制备方法获得的组合物,采用辩证的方法有效的达 到调理肠道与五脏六腑的功效, 无毒副作用, 效果稳定, 与西药相比 达到事半功倍的疗效。 临床实验 1: The prepared Chinese medicine composition solution preparation can be used for oral administration, and if it can be consumed once in the morning and evening, and it is used for a long time, the effect is better. The theoretical basis of the invention is: cassia twig, which is a dry twig of cinnamon of the evergreen tree plant of the family Aphididae, mainly produced in Guangxi, Guangdong and Yunnan. Cut the shoots in spring and summer, dry or dry, cut into thin slices or small sections. The taste of Xin Wen, has the function of warming the veins, dispelling the cold, and treating the qi stagnation caused by insufficient yang Blood coagulation, abdominal pain, cold blood stasis, etc., can also treat colds caused by cold, cold, cough and other diseases have a good effect. The extract of osmanthus fragrans can inhibit Escherichia coli, Bacillus subtilis and Staphylococcus aureus in vitro, with an effective concentration of 25 mg/ml or less; against Staphylococcus aureus, Shigella dysenteriae, Typhoid fever and Parahaemolyticus, Pneumococcal , Azotobacter, Proteus, Bacillus anthracis, Salmonella enteritidis, Vibrio cholerae, etc. also have inhibitory effects. Codonopsis pilosula has anti-gastrointestinal mucosal damage, pharmacological effects related to Buzhong Yiqi and spleen-suppressing effects to adjust gastrointestinal motility and anti-ulcer. It has the functions of enhancing immune function, enhancing hematopoietic function, anti-stress, cardiotonic, anti-shock, regulating blood pressure, resisting myocardial ischemia and inhibiting platelet aggregation. Dangshen also has the functions of puzzle, calmness, hypnosis and anti-convulsion. Dangshen has the effect of replenishing vital energy, strengthening the spleen and benefiting the lungs. For spleen and lung weakness. Dried ginger, is a dried ginger, spicy, hot, spleen, stomach, heart, lung. It has the effect of warming and dispelling cold, returning to Yangtongmai, warming lung and drinking. It is used for spleen and stomach yang deficiency and has a cold syndrome. It can not be seen in the disease, vomiting water, loose stools, cold abdominal pain, pale tongue, white veins Subtle and so on. Radix Pseudostellariae, also known as ginseng, is a kind of ginseng. It has a calming, sweet taste and a tonifying effect. It is often used for spleen and stomach weakness, lack of stomach yin, fatigue, indigestion, loss of appetite and so on. Licorice, a kind of tonic Chinese herbal medicine, the medicinal parts are roots and rhizomes. The roots of the medicinal properties are cylindrical, with spleen and qi, clearing away heat and detoxification, relieving cough, relieving pain, and reconciling various medicines. The role of; for spleen and stomach weakness, fatigue, fatigue, palpitations, shortness of breath, cough, abdominal pain, limbs, acute pain, swollen sore, relieve drug toxicity, potency. Woody, is the general name for the genus Yunmuxiang and Chuanmuxiang, and is the dry root of the woody scent of Compositae. Woody has an antibacterial effect, can inhibit the regeneration of gastrointestinal bacteria, and can also inhibit the reproduction of liver virus replication, and play a role in reducing inflammation and protecting the liver. Clam shell, bitter taste, cool, into the lungs, spleen, large intestine, broken gas, sputum, elimination, treatment of chest stagnation, chest, bloating, food, belching, vomiting, diarrhea Heavy, rectal prolapse, uterine prolapse and other effects. Longan core, miso, qi and pain, hemostasis, moisture absorption, etc., can be used for hernia pain, traumatic bleeding, phlegm, wet sores and so on. Disperse wind and evil spirits, cure dizziness, deafness, and vertigo. Warm kidney diuretic, hemostasis, pain, qi, dampness; attending sputum evil, treating anorexia, loss of appetite, repelling parasites and schistosomiasis. Long-term consumption, strong body sputum, longevity, soothe the nerves and long wisdom, appetizing spleen, complement deficiency. The bergamot, also known as the five-finger orange, bergamot, its roots, stems, leaves, flowers, and fruit can be used as medicine, bitter, spicy, sweet, warm, into the liver, spleen, stomach, lung, rational gasification, coughing It has many medicinal functions such as swelling, soothing liver and strengthening spleen and gastrointestinal tract. It has the functions of soothing liver and relieving stagnation, dampness and phlegm, qi and qi. It is often used for liver qi stagnation, spleen and stomach qi stagnation and phlegm and blood stasis. . Chicken gold, sweet and flat, into the spleen and stomach, containing stomach hormone, micro pepsin, amylase, multivitamins, increase gastric secretion and gastrointestinal digestion, speed up the gastrointestinal The effect of emptying rate, such as Jianweixiaoshi, solid essence, fossil-to-leaf, and can transport the spleen and stomach, can cure the food and stagnation, is a good medicine for stomach and digestion. Chenpi, alias agarwood, spicy, bitter, warm; spleen, stomach, lung; qi scent, can be ascending or descending; Chenpi's bitter substance is represented by limonin and bitterin ", this kind of lemon bitter tastes calm, easy to dissolve in water, helps digestion of food; has the effect of qi and medium, dampness and phlegm, and water and laxative. Indications for spleen and stomach discomfort, abdominal pain, spleen and stomach weakness, loss of appetite, vomiting hiccups, limb weakness and other symptoms, and Codonopsis, dried ginger, yam equivalent, the effect is better. Agarwood, pungent, bitter, slightly warm, spleen, stomach, kidney, with qi and pain, warm cessation, warm kidney and other effects, attending vomiting hiccups, abdominal pain, waist and knee cold, large intestine deficiency , chest and abdomen swelling and pain, stomach cold vomiting hiccups, kidney deficiency, gas and asthma. Angelica, a perennial herb, distributed in Gansu, Yunnan, Sichuan, Qinghai, Shaanxi, Hunan, Hubei, Guizhou, etc., cultivated everywhere. The root of Angelica is one of the most commonly used Chinese medicines. Angelica has the effect of warming meridians, promoting blood circulation and relieving pain, whether it is cold and abdominal pain, or rheumatoid joint pain, or bruises and blood stasis. Angelica is also commonly used in hemorrhoids. Because Angelica activating blood circulation and dissipating blood stasis, it can reduce swelling and relieve pain and discharge pus muscle. The famous Fangfang Xianfang Live Drink for treating sores is equivalent to Angelica and Red Oak, Honeysuckle and Gunsan. Ophiopogon japonicus is a perennial evergreen grass plant of the genus Liliaceae. The fibrous roots are thicker and thicker. The top or middle part of the root is often expanded into a spindle-shaped succulent piece, which is used as a root. Slightly cold, taste It is slightly bitter and medicinal experiments have proved that Maimendong has the effect of increasing white blood cells, prolonging the existence time of antibodies, improving immune function and nucleic acid synthesis rate, and promoting the production of immune substances such as antibodies, complement, interferon and lysozyme. Therefore, Ophiopogon has the effect of strengthening the righteousness and strengthening the anti-evil effect, thereby reducing the incidence of disease. It is used for lung and stomach yin deficiency, less thirst, dry cough and hemoptysis, heart yin deficiency, heart irritability and fever, and late heat injury. Calcined scorpion, sweet, flat, liver, lung, stomach. It has the effects of eliminating phlegm and dissipating phlegm, softening and firming, and acid-relieving pain. Mainly used for pantothenic acid, stubborn accumulation, sticky and difficult to embolize. Astragalus, Astragalus, alias Camellia root, earth tea root. For the plant of the Labiatae, the root is used as a medicine. It has heat and dampness, cool blood and fetus, detoxification effect. Indications for warm disease, upper respiratory tract infection, lung heat cough, damp heat yellow biliary, pneumonia, dysentery, hemoptysis, red eyes, fetal dysphoria, high blood pressure, carbuncles and hemorrhoids. The clinical application of Astragalus is better than berberine and does not produce drug resistance. Big blood vine, bitter, flat. Return to the large intestine and liver. Indications: Detoxification, blood circulation, hurricane. For intestinal pain, abdominal pain, menstrual dysmenorrhea, rheumatism, pain, swelling and swelling. It has the functions of detoxification, promoting blood circulation and collaterals, and killing insects. Emergency treatment, chronic appendicitis, rheumatic pain, red sputum, bloody, irregular menstruation, hoarding, insect pain, fall damage and other symptoms. White peony, cold, bitter, sweet, sputum, non-toxic; return to the lungs, stomach, liver. It has the function of astringent hemostasis, swelling and muscle growth. Indications for pulmonary sputum, blood vomiting, blood stasis, blood in the stool, traumatic bleeding, hemorrhoids, sputum, sputum, burns, hand and foot cleft palate, anal fissure and other diseases. In combination with other traditional Chinese medicines of the invention, the effect of treating enteritis is obvious. Jujube, sweet and warm, spleen and stomach, rich in protein, fat, sugar, carotene, B vitamins, vitamin C, vitamin P and calcium, phosphorus, iron and cyclic adenosine monophosphate and other nutrients. Among them, the content of vitamin C is among the best in the fruit, and it has the reputation of vitamin king. It has the effect of replenishing vital energy, strengthening the spleen and stomach, nourishing blood and calming the nerves, and alleviating the medicinal properties. It is used for spleen deficiency, fatigue, and impotence. From the perspective of traditional Chinese medicine, the etiology and pathogenesis of chronic enteritis, there are diets, bruises in Zhongzhou, or exogenous invasion, damage to the spleen and stomach, or worry about anger, liver loss, diarrhea, and lack of endowment The spleen and stomach are weak, and the disease is in the "intestine", but it is closely related to "stomach", "spleen", "liver" and "kidney". The pathogenesis is characterized by imaginary inclusion, so the above traditional Chinese medicine by the present invention The composition obtained by the compatibility and the preparation method can effectively achieve the effect of regulating the intestinal tract and the internal organs by using a dialectical method, has no toxic and side effects, and has stable effects, and achieves twice the result with half the effort with western medicine. Clinical Experiment 1:
1 )、观察时间:在本发明技术方案未曾披露的情况下,选择 2012 年 4月到 2012年 9月的 6个月时间。 1) Observation time: In the case where the technical solution of the present invention has not been disclosed, the time from April 2012 to September 2012 is selected.
2 )、观察对象: 在广东省深圳市中医院消化科选择 10例慢性肠 炎病例: 男 4例, 女 6例; 年龄: 40— 55岁 5例, 60— 75岁 5例; 职业: 普通上班族 5例, 退休人员 5例。 病症: 反复发作的腹痛、 腹 胀、 腹泻、 泻下粘液或脓血便, 发作期大便 3次 /日以上, 伴排便不
畅或里急后重; 舌苔多黄腻或白腻; 全部病便均经纤维结肠镜检査确 诊。 2), observation object: 10 cases of chronic enteritis were selected in the Department of Gastroenterology, Shenzhen Hospital of Guangdong Province: 4 males and 6 females; age: 5 cases of 40-55 years old, 5 cases of 60-75 years old; Occupation: General work There are 5 families and 5 retirees. Symptoms: recurrent abdominal pain, bloating, diarrhea, diarrhea mucus or pus and bloody stools, 3 times/day of bowel movements during episodes, with defecation Chang or urgency and heavy; tongue coating more yellow or greasy; all cases were diagnosed by fiberoptic colonoscopy.
3 ) 、 使用方法: 将本发明制剂口服液在餐后半小时服用, 每日 3次, 每次 200ml, 2个月为 1疗程, 3个疗程作为疗效观察。 3), How to use: The oral solution of the preparation of the present invention is taken half an hour after a meal, 3 times a day, 200 ml each time, 2 months for a course of treatment, and 3 courses of treatment as therapeutic effects.
4 )、 观察效果: 4), observation effect:
在连续服用 3个疗程后, 临床症状、 体征消失, 纤维结肠镜复査 正常, 肠黏膜病变恢复正常的 5例, 临床症状明显减轻, 体征基本消 失, 纤维结肠镜复査好转, 肠黏膜病变明显改善的 3例, 治疗前后临 床症状和体征无改善,纤维结肠镜复査无好转的 2例,总有效率 80%。 After taking 3 courses of treatment continuously, the clinical symptoms and signs disappeared, the fiber colonoscopy was normal, and the intestinal mucosal lesions returned to normal in 5 cases. The clinical symptoms were obviously relieved, the signs disappeared, the fiber colonoscopy was improved, and the intestinal mucosal lesions were obvious. In the 3 cases improved, there were no improvement in clinical symptoms and signs before and after treatment, and 2 cases with no improvement in fiber colonoscopy, the total effective rate was 80%.
临床实验 2: Clinical trial 2:
1 )、观察时间: 在本发明技术方案未曾披露的情况下, 选择 2013 年 2月到 2013年 7月的 6个月时间。 1) Observation time: In the case where the technical solution of the present invention has not been disclosed, the time from February 2013 to July 2013 is selected.
2 )、 观察对象: 在广东省深圳市福田区中医院消化科选择 20例 病例: 男 13例, 女 7例; 年龄: 32— 55岁 10例, 56— 75岁 10例; 职业: 曾担任领导岗位公务员 10例, 普通教师 10例。 病症: 反复发 作的腹痛、 腹胀、 腹泻、 泻下粘液或脓血便, 发作期大便 3次 /日以 上, 伴排便不畅或里急后重; 舌苔多黄腻或白腻; 全部病便均经纤维 结肠镜检査确诊。 2), Observed: 20 cases were selected in the Department of Gastroenterology, Futian District Hospital of Shenzhen, Guangdong Province: 13 males and 7 females; age: 10 cases of 32-55 years old, 10 cases of 56-75 years old; Occupation: There were 10 civil servants in leadership positions and 10 in general. Symptoms: recurrent abdominal pain, bloating, diarrhea, diarrhea mucus or pus and bloody stools, 3 times/day of bowel movements during episodes, with poor bowel movements or heavy urgency; thick yellow tongue or greasy tongue; all cases are treated with fiberoptic colonoscopy Check the diagnosis.
3 )、 使用方法: 将本发明制剂口服液在餐后半小时服用, 每日 3 次, 每次 200ml, 2个月为 1疗程, 3个疗程作为疗效观察。 3), How to use: The oral solution of the preparation of the present invention is taken half an hour after a meal, 3 times a day, 200 ml each time, 2 months for a course of treatment, and 3 courses for observation of curative effect.
4 )、 观察效果:
在连续服用 3个疗程后, 临床症状、 体征消失, 纤维结肠镜复査 正常, 肠黏膜病变恢复正常的 14例, 临床症状明显减轻, 体征基本 消失, 纤维结肠镜复査好转, 肠黏膜病变明显改善的 1例, 治疗前后 临床症状和体征无改善, 纤维结肠镜复査无好转的 5 例, 总有效率 75%。 4), observation effect: After taking 3 courses of treatment, the clinical symptoms and signs disappeared, the fiber colonoscopy was normal, and 14 cases of intestinal mucosal lesions returned to normal. The clinical symptoms were obviously relieved, the signs disappeared, the colonoscopy was improved, and the intestinal mucosal lesions were obvious. In 1 case of improvement, there were no improvement in clinical symptoms and signs before and after treatment, and 5 cases of no improvement in fiberoptic colonoscopy, the total effective rate was 75%.
临床实验 3: Clinical Trial 3:
1 )、观察时间: 在本发明技术方案未曾披露的情况下, 选择 2013 年 8月到 2014年 1月的 6个月时间。 1) Observation time: In the case where the technical solution of the present invention has not been disclosed, the time period from August 2013 to January 2014 is selected.
2 )、 观察对象: 在广东省深圳市松岗人民医院消化科选择 30例 病例: 男 15例, 女 15例; 年龄: 35— 55岁 16例, 60— 75岁 14例; 职业: 普通民营企业主 14例, 普通退休教师 16例。 病症: 反复发作 的腹痛、腹胀、腹泻、泻下粘液或脓血便,发作期大便 3次 /日以上, 伴排便不畅或里急后重; 舌苔多黄腻或白腻; 全部病便均经纤维结肠 镜检査确诊。 2), Observed subjects: 30 cases were selected in the Department of Gastroenterology, Songgang People's Hospital, Shenzhen, Guangdong Province: 15 males and 15 females; Age: 16 cases of 35-55 years old, 14 cases of 60-75 years old; Occupation: Ordinary private enterprise There are 14 main cases and 16 ordinary retired teachers. Symptoms: recurrent abdominal pain, bloating, diarrhea, diarrhea mucus or pus and bloody stools, 3 times/day of bowel movements during episodes, with poor bowel movements or heavy urgency; thick yellow tongue or greasy tongue; all cases are treated with fiberoptic colonoscopy Check the diagnosis.
3 )、 使用方法: 将本发明制剂口服液在餐后半小时服用, 每日 3 次, 每次 200ml, 2个月为 1疗程, 3个疗程作为疗效观察。 3), How to use: The oral solution of the preparation of the present invention is taken half an hour after a meal, 3 times a day, 200 ml each time, 2 months for a course of treatment, and 3 courses for observation of curative effect.
4 )、 观察效果: 4), observation effect:
在连续服用 3个疗程后, 临床症状、 体征消失, 纤维结肠镜复査 正常, 肠黏膜病变恢复正常的 19例, 临床症状明显减轻, 体征基本 消失, 纤维结肠镜复査好转, 肠黏膜病变明显改善的 5例, 治疗前后 临床症状和体征无改善, 纤维结肠镜复査无好转的 6 例, 总有效率 80%。
结合以上临床数据及本发明的理论依据,可见本发明有益效果在 于,本发明制成的制剂,对于治疗慢性肠炎具有良好效果,而且无毒, 无副作用, 效果稳定, 制取工艺简便易行。 具体实 式 After taking 3 courses of treatment continuously, the clinical symptoms and signs disappeared, the fiber colonoscopy was normal, and the intestinal mucosal lesions returned to normal in 19 cases. The clinical symptoms were alleviated, the signs disappeared, the fiber colonoscopy was improved, and the intestinal mucosal lesions were obvious. In 5 cases improved, there were no improvement in clinical symptoms and signs before and after treatment, and 6 cases with no improvement in fiberoptic colonoscopy, the total effective rate was 80%. Combined with the above clinical data and the theoretical basis of the present invention, it can be seen that the preparation prepared by the invention has good effects for treating chronic enteritis, is non-toxic, has no side effects, has stable effects, and is simple and easy to prepare. Concrete real
下面结合实施例对本发明详细加以说明: The present invention will be described in detail below with reference to the embodiments:
实施例 1: Example 1:
本发明制剂是由桂枝、党参、干姜、太子参、甘草、木香、枳壳、 龙眼核、佛手、鸡内金、 陈皮、沉香、 当归、麦冬、煅瓦楞子、黄芩、 大血藤、白芨和大枣制备成的组合物制剂,其中各组分的质量配比为 桂枝 12g 党参 10g The preparation of the invention is from cassia twig, codonopsis pilosula, dried ginger, ginseng ginseng, licorice, woody scent, oyster shell, longan nucleus, bergamot, chicken inner gold, orange peel, agarwood, angelica, yoghurt, calcined scorpion, scutellaria, big blood A preparation preparation of vine, white peony and jujube, wherein the mass ratio of each component is Guizhi 12g Codonopsis 10g
太子参 12g 甘草 12g Radix Pseudostellariae 12g Licorice 12g
鸡内金 15g 陈皮 15g 沉香 3g 当归 12g 麦冬 8g 煅瓦楞子 10g 黄芩 12g 血藤 13g 白芨 10g 大 16g0 Chicken inner gold 15g dried tangerine peel 15g agarwood 3g Angelica 12g Ophiopogon japonicus 8g Calcined corrugated hazelnut 10g Astragalus 12g Blood vine 13g White peony 10g Large 16g 0
上述治疗慢性肠炎中药制剂的制备方法, 包括如下歩骤: The above preparation method for treating a traditional Chinese medicine preparation for chronic enteritis comprises the following steps:
1 )、将党参放入小锅进行小炒至表面微焦, 然后经粉碎机粉碎并 过 80目筛, 备用;
黄芩、 大血藤按比例配好, 经过粉碎机粉碎成粉末并过 90 目筛, 自 然晾干, 备用; 1), put the Codonopsis in a small pot and stir fry until the surface is slightly coke, and then crushed by a pulverizer and passed through a 80 mesh sieve for use; Astragalus membranaceus and big blood vine are proportioned well, pulverized into powder by a pulverizer and passed through a 90 mesh sieve, and dried naturally for use;
3 )、 将歩骤 1 ) 和 2 ) 中的各组分粉末混合在一起, 加入纯净水 煎煮两次, 第一次加入 8倍纯净水小火煎煮 1小时, 第二次加入 4倍 纯净水小火煎煮半小时, 然后合并煎液并过滤, 备用; 3), mix the powders of each component in steps 1) and 2), add boiling water twice, add 8 times pure water for 1 hour, simmer for 1 hour, and add 4 times for the second time. Decoction in pure water for half an hour, then combine the decoction and filter, set aside;
4 )、 将剩下的木香、 鸡内金、 陈皮、 沉香、 当归、 麦冬、 煅瓦楞 子、 白芨按比例配好, 经过粉碎机粉碎成粉末并过 80 目筛, 自然晾 干, 备用; 4), the remaining woody, chicken gold, dried tangerine peel, agarwood, angelica, Ophiopogon japonicus, calyx scorpion, white peony proportioned well, pulverized into a powder by a pulverizer and passed through a 80 mesh sieve, naturally dried, spare ;
5 )、 将歩骤 4) 中各组分粉末混合在一起, 加入 4〜6倍70%〜80% 的乙醇, 加热回流 3〜5个小时, 提取过滤获得滤液; 然后在剩下的药 渣中再次加入 2〜4倍65%〜75%的乙醇, 加热回流 2〜3个小时, 提取过 滤获得滤液;将两次获得的滤液合并在一起,减压浓缩除去乙醇溶剂, 干燥, 获得干膏; 5), mixing the powders of each component in step 4), adding 4 to 6 times 70%~80% ethanol, heating and refluxing for 3 to 5 hours, extracting and filtering to obtain a filtrate; and then remaining the dregs Adding 2 to 4 times of 65% to 75% ethanol again, heating and refluxing for 2 to 3 hours, extracting and filtering to obtain a filtrate; combining the filtrates obtained twice, removing the ethanol solvent under reduced pressure, and drying to obtain a dry paste. ;
6 )、 将上述歩骤 5 ) 中获得的干膏进行超微粉碎成粉末并过 200 目筛, 然后将粉末加入歩骤 3 ) 中的合并煎液, 混合摇匀即可制得。 6), the dry paste obtained in the above step 5) is ultra-pulverized into a powder and passed through a 200 mesh sieve, and then the powder is added to the combined decoction in the step 3), and mixed and shaken to obtain.
制取的上述中药组合物溶液制剂可以用于口服,如果能够早中晚 各饮用一次并长期饮用, 效果更好。 The preparation of the above-mentioned traditional Chinese medicine composition solution can be used for oral administration, and if it can be consumed once in the morning and evening and long-term drinking, the effect is better.
实施例 2: Example 2:
本发明还可优选的原料质量为 (克): The preferred raw material quality of the present invention is (g):
桂枝 12g 党参 10g 干姜 10g 太子参 12g 甘草 12g 木香 15g 枳壳 10g 龙眼核 12g 佛手 8g
鸡内金 15g 陈皮 10g 13g 当归 12g 麦冬 8g 煅瓦楞子 黄芩 12g 大血藤 13g 白芨 10g 大 16g。 Guizhi 12g Codonopsis 10g Ginger 10g Pseudostellariae 12g Licorice 12g Woody 15g Clam Shell 10g Longan Nuclear 12g Bergamot 8g Chicken inner gold 15g dried tangerine peel 10g 13g Angelica 12g Ophiopogon japonicus 8g Calcined corrugated scorpion Astragalus membranaceus 12g Large blood vine 13g White peony 10g Large 16g.
制备方法如实施例 1。 The preparation method is as in Example 1.
实施例 3; Example 3;
本发明还可优选的原料质量为 (克): The preferred raw material quality of the present invention is (g):
桂枝 15g 党参 12g Guizhi 15g Codonopsis 12g
太子参 15g 甘草 10g 木香 12g 枳壳 12g 龙眼核 10g 佛手 8g 鸡内金 12g 陈皮 g 沉香 12g 当归 8g 麦冬 8g 煅瓦楞子 12g 黄芩 10g 大血藤 8g
10g 大枣 15go Radix ginseng 15g licorice 10g woody 12g oyster shell 12g longan core 10g bergamot 8g chicken inner gold 12g orange peel agarwood 12g angelica 8g maidong 8g calcined scorpion 12g scutellariae 10g big blood vine 8g 10g jujube 15go
制备方法如实施例 1。 The preparation method is as in Example 1.
实施例 4: Example 4:
本发明还可优选的原料质量为 (克): The preferred raw material quality of the present invention is (g):
桂枝 18g 党参 15g 干姜 12g 太子参 16g 甘草 12g 木香 15g 枳壳 13g 龙眼核 15g 佛手 12g 鸡内金 16g 陈皮 14g 沉香 16g
当归 10g :冬 12g '煅瓦楞子 15g 黄芩 16g :血藤 13g 白芨 12g 大枣 18g。 Guizhi 18g Codonopsis 15g Dried ginger 12g Radix Pseudostellariae 16g Licorice 12g Woody 15g Clam shell 13g Longan core 15g Bergamot 12g Chicken inner gold 16g Tangerine 14g Agarwood 16g Angelica 10g: Winter 12g 'calcined wolfberry 15g Astragalus 16g: blood vine 13g white peony 12g jujube 18g.
制备方法如实施例 1。 The preparation method is as in Example 1.
实施例 5: Example 5
本发明还可优选的原料质量为 (克): The preferred raw material quality of the present invention is (g):
桂枝 16g 党参 18g 干姜 15g 太子参 14g 甘草 15g 木香 18g 枳壳 15g 龙眼核 18g 佛手 14g 鸡内金 18g 陈皮 16g 沉香 14g 当归 12g 麦冬 13g 煅瓦楞子 黄芩 18g 大血藤 15g 白芨 15g 18g Guizhi 16g Codonopsis 18g Dried ginger 15g Radix Pseudostellariae 14g Licorice 15g Woody 18g Clam shell 15g Longan nucleus 18g Bergamot 14g Chicken inner gold 18g Tangerine 16g Agarwood 14g Angelica 12g Ophiopogon 13g Calcined scorpion Astragalus 18g Large blood vine 15g White peony 15g 18g
制备方法如实施例 1。 The preparation method is as in Example 1.
实施例 6: Example 6:
本发明还可优选的原料质量为 (克): The preferred raw material quality of the present invention is (g):
桂枝 15g 党参 18g 干姜 15g 太子参 16g 甘草 15g 木香 20g 枳壳 12g 龙眼核 20g 佛手 16g 鸡内金 16g 陈皮 18g 沉香 15g 当归 15g 麦冬 15g 煅瓦楞子 黄尊 16g 大血藤 16g 白芨 13g
大枣 20g。 Guizhi 15g Codonopsis 18g Dried ginger 15g Radix Pseudostellariae 16g Licorice 15g Woody 20g Clam shell 12g Longan core 20g Bergamot 16g Chicken inner gold 16g Chenpi 18g Agarwood 15g Angelica 15g Ophiodon 15g Calcined wolfberry yellow Zun 16g Large blood vine 16g White peony 13g Jujube 20g.
制备方法如实施例 1。 The preparation method is as in Example 1.
上述实施例仅是本发明众多实施方式的几种,如将各配方按技术方案 中的比例加大或减小药量,制得的这种治疗慢性肠炎制剂疗效并不受 影响, 也将落在本发明的权利保护范围之内。
The above embodiments are only a few of the various embodiments of the present invention, such as increasing or decreasing the dosage of each formulation according to the technical solution, the therapeutic effect of the preparation of the chronic enteritis preparation is not affected, and will also fall. It is within the scope of the claims of the present invention.
Claims
1、 一种治疗慢性肠炎的中药制剂, 其特征在于, 本发明制剂是 由桂枝、 党参、 干姜、 太子参、 甘草、 木香、 枳壳、 龙眼核、 佛手、 鸡内金、 陈皮、 沉香、 当归、 麦冬、 煅瓦楞子、 黄芩、 大血藤、 白芨 和大枣制备成的组合物制剂, 其中各组分的质量配比为: 桂枝 12- 20g 10-22g 姜 8-18g 太子 10-18g 草 8- 15g 木香 1. A traditional Chinese medicine preparation for the treatment of chronic enteritis, characterized in that the preparation of the present invention is composed of cassia twig, Codonopsis root, dried ginger, Pseudostellariae Radix, licorice, costus, Citrus aurantium, longan core, bergamot, Gallus gallus gallus domesticus, tangerine peel, A composition preparation prepared from agarwood, angelica root, Ophiopogon japonicus, calcined corrugated fruit, skullcap, bloodvine, bletilla striata and jujube, in which the mass ratio of each component is: Guizhi 12-20g 10-22g Ginger 8-18g Prince 10-18g Grass 8-15g Woody
10— 20g 枳壳 8-16g 龙眼核 12-20g 手 8-16g 鸡内金 10-18g 陈皮 10-18g
10-18g 10-20g Citrus aurantium husk 8-16g Longan core 12-20g Hand 8-16g Chicken gizzard 10-18g Tangerine peel 10-18g 10-18g
8 - 15g 麦冬 6-15g 煅瓦楞子 8-15g Ophiopogon japonicus 6-15g Forged corrugated seeds
8-15g 8-15g
沉 黄芩 10- 18g :血藤 8-16g 8-15香g 大枣 10- 20g。 Chen Scutellaria 10-18g: Blood Teng 8-16g 8-15g Jujube 10-20g.
2、 根据权利要求 1所述的治疗慢性肠炎的中药制剂, 其特征还 在于, 其中各组分的质量配比为: 桂枝 12- 18g 党参 10-18g 干姜 8-12g 太子 12-18g 甘草 8-12g 木香 2. The traditional Chinese medicine preparation for treating chronic enteritis according to claim 1, further characterized in that the mass ratio of each component is: Guizhi 12-18g Codonopsis pilosula 10-18g Dried ginger 8-12g Prince Edward 12-18g Licorice 8-12g woody scent
10-15g 枳壳 8-12g 佛手 8-12g 鸡内金 10-15g 陈. 10— 14g
10-15g 10-15g Citrus aurantium 8-12g Bergamot 8-12g Chicken gizzard 10-15g Chen. 10- 14g 10-15g
当归 8-12g 冬 6- lOg 煅瓦楞子 Angelica sinensis 8-12g winter 6-lOg forged corrugated seeds
8-12g 8-12g
黄芩 10-15g :血藤 8-12g 白芨 8-12g 大枣 12-18g( Scutellaria baicalensis 10-15g: Scutellaria baicalensis 8-12g, Bletilla striata 8-12g, jujube 12-18g (
3、 根据权利要求 1或 2所述的治疗慢性肠炎的中药制剂, 其特 征还在于, 其中各组分的质量配比为 3. The traditional Chinese medicine preparation for treating chronic enteritis according to claim 1 or 2, which is further characterized in that the mass ratio of each component is
桂枝 15g 党参 12g 干姜 9g Guizhi 15g Codonopsis pilosula 12g Dried ginger 9g
太子参 15g 甘草 10g 木香 12g 枳壳 12g 龙眼核 10g 佛手 8g 鸡内金 12g 陈皮 14g 沉香 12g Pseudostellariae Radix Pseudostellariae 15g Licorice 10g Costus 12g Citrus aurantium 12g Longan core 10g Bergamot 8g Gallus gallus gallus L. 12g Tangerine peel 14g Agarwood 12g
当归 8g 麦冬 8g 煅瓦楞子 12g 黄芩 10g 大血藤 8g 白芨 10g Angelica sinensis 8g, Ophiopogon japonicus 8g, Forged corrugated seeds 12g, Scutellaria baicalensis 10g, Bloodvine 8g, Bletilla striata 10g.
大 15g0 Large 15g 0
4、 一种治疗慢性肠炎的中药制剂的制备方法, 其特征在于, 其 包括如下歩骤: 4. A method for preparing a traditional Chinese medicine preparation for treating chronic enteritis, which is characterized in that it includes the following steps:
1 )、将党参放入小锅进行小炒至表面微焦, 然后经粉碎机粉碎并 过 80目筛, 备用; 1). Put the Codonopsis pilosula into a small pot and stir-fry until the surface is slightly charred, then grind it with a grinder and pass it through an 80-mesh sieve, and set aside;
2 )、将桂枝、干姜、太子参、甘草、枳壳、龙眼核、佛手、大枣、 黄芩、 大血藤按比例配好, 经过粉碎机粉碎成粉末并过 90 目筛, 自 然晾干, 备用; 2). Mix the cinnamon twig, dried ginger, heterophylla heterophylla, licorice, citrus aurantium, longan core, bergamot, jujube, scutellaria baicalensis, and blood rattan in proportion, grind it into powder through a crusher, pass it through a 90-mesh sieve, and let it dry naturally. dry, set aside;
3 )、 将歩骤 1 ) 和 2 ) 中的各组分粉末混合在一起, 加入纯净水
煎煮两次,第一次加入 10倍纯净水小火煎煮 1小时,提取滤液备用, 第二次加入 6倍纯净水小火煎煮半小时,然后合并煎液并过滤,备用; 3). Mix the powder components in steps 1) and 2) together and add purified water. Decoct twice. For the first time, add 10 times purified water and cook over low heat for 1 hour. Extract the filtrate and set aside. For the second time, add 6 times purified water and cook over low heat for half an hour. Then combine the decoctions and filter and set aside.
4 )、 将剩下的木香、 鸡内金、 陈皮、 沉香、 当归、 麦冬、 煅瓦楞 子、 白芨按比例配好, 经过粉碎机粉碎成粉末并过 80 目筛, 自然晾 干, 备用; 4). Mix the remaining costus, gallinaceae, tangerine peel, agarwood, angelica, ophiopogon japonicus, calcined corrugated seeds, and bletilla striata in proportion, grind into powder through a grinder and pass through an 80-mesh sieve, dry naturally and set aside. ;
5 )、 将歩骤 4) 中各组分粉末混合在一起, 加入 4〜6倍70%〜80% 的乙醇, 加热回流 3〜5个小时, 提取过滤获得滤液; 然后在剩下的药 渣中再次加入 2〜4倍65%〜75%的乙醇, 加热回流 2〜3个小时, 提取过 滤获得滤液;将两次获得的滤液合并在一起,减压浓缩除去乙醇溶剂, 干燥, 获得干膏; 5). Mix the powders of each component in step 4) together, add 4 to 6 times of 70% to 80% ethanol, heat and reflux for 3 to 5 hours, extract and filter to obtain the filtrate; then add the remaining medicinal residue. Add 2 to 4 times of 65% to 75% ethanol again, heat and reflux for 2 to 3 hours, extract and filter to obtain the filtrate; combine the two filtrate obtained together, concentrate under reduced pressure to remove the ethanol solvent, and dry to obtain a dry paste. ;
6 )、 将上述歩骤 5 ) 中获得的干膏进行超微粉碎成粉末并过 200 目筛, 然后将粉末加入歩骤 3 ) 中的合并煎液, 混合摇匀即可制得。 制取的上述中药组合物溶液制剂可以用于口服,如果能够早中晚各适 量饮用一次并长期饮用, 效果更好。
6). Ultrafinely pulverize the dry paste obtained in the above step 5) into powder and pass it through a 200 mesh sieve. Then add the powder to the combined decoction in step 3), mix and shake well to prepare. The prepared above-mentioned Chinese medicine composition solution preparation can be taken orally. If it can be drunk once in the morning, noon and evening in an appropriate amount and for a long time, the effect will be better.
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CN103301439A (en) * | 2013-07-09 | 2013-09-18 | 朱克兰 | Traditional Chinese medicine composition for treating chronic enteritis and preparation method thereof |
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CN103301439A (en) * | 2013-07-09 | 2013-09-18 | 朱克兰 | Traditional Chinese medicine composition for treating chronic enteritis and preparation method thereof |
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