CN103585434B - Traditional Chinese medicine composition for treating anemia - Google Patents
Traditional Chinese medicine composition for treating anemia Download PDFInfo
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Abstract
The invention discloses traditional Chinese medicine composition for treating anemia, belongs to the technical field of medicine, and aims at solving the problem that chemotherapeutic drugs for treating the anemia are high in hepatotoxicity at present. The traditional Chinese medicine composition for preventing or treating the anemia comprises raw materials in parts by weight as follows: 10-18 parts of Chinese angelica, 5-8 parts of donkey-hide gelatin, 8-12 parts of Chinese dates, 8-12 parts of caulis spatholobi, 8-12 parts of radix asparagi, 18-22 parts of fruit of Chinese magnoliavine, 18-22 parts of ligusticum wallichii, 18-22 parts of lotus leaves, 5-7 parts of radix paeoniae alba, 5-8 parts of bighead atractylodes rhizome, 12-16 parts of polygala tenuifolia, 5-8 parts of burdock, 8-12 parts of wolfberry and 8-12 parts of liquorice. The traditional Chinese medicine composition has a good treatment effect in treating the anemia and obvious clinical promotional values.
Description
Technical field
The invention belongs to medical art, be specifically related to a kind of Chinese medicine composition for the treatment of anemia.
Background technology
Anemia (anemia) refers to that in systemic circulation blood, red blood cell mass is reduced to below normal value.But due to the determination techniques more complicated of red blood cell mass in systemic circulation blood, so the concentration referring generally to peripheral hemoglobin and blood is clinically lower than the same age group of patient, with sex and the arm's length standard with area.Domestic arm's length standard is more lower slightly than external standard.Coastal and plains region, the hemoglobin of man is as lower than 12.5g/dl, and the hemoglobin of woman, lower than 11.0g/dl, can think there is anemia.
The sickness rate of anemia is high, comprises iron deficiency anemia, macrocytic, aplastic anemia and hemolytic anemia four kinds.Wherein modal is iron deficiency anemia, and with child and anemia of pregnant woman's sickness rate for height, China's less than 7 years old infantile anemia sickness rate is up to 40%.The weight of Anemia depends primarily on the degree of anemia and produces reason and the speed of anemia, and the faster symptom of speed producing anemia is more serious, and the anemia slowly occurred is due to the adaptability of human body and replacement, and symptom is relatively light.General iron deficiency anemia does not need Drug therapy, and diet raises treating blood disorders cell and hemoglobin level will return to normal level.The Anemic patients of the overwhelming majority then needs just can return to normal level by the intervention of medicine.Current western medical treatment is mainly symptomatic treatment, immunosuppressant therapy, there is erious adverse reaction, immunosuppressant therapy, causes the resistance of patient to decline, easily causes some complication; The cure rate of western medical treatment is low, and easily recurrence after curing, and adopt western medical treatment comparatively large to the damage of human body, and the course for the treatment of is longer, causes huge shade to the psychosoma of patient.The traditional Chinese medical science and Chinese medicine then also exist advantage in treatment anemia, and Chinese medicine and Chinese patent medicine can produce therapeutical effect to polytype anemia.
The history of Chinese medicine anemia is of long standing and well established, and have accumulated abundant theory of Chinese medical science and clinical experience.The traditional Chinese medical science is thought, anemia is weak mainly due to natural endowment, or eating and drinking without temperance, or prolonged illness is lost blood, so that caused by spleen-kidney deficiency.Taste are the source of QI and bloodization life, and blood is mainly derived from essence of water and grain, and the change of essence of water and grain is raw, then the main absorption and digestion by middle burnt taste.If dietetic nutrition Deficiency of Intake, or transformation and transportation of the spleen and stomach long-run disturbance, then the generation of blood all can be caused not enough, thus form the pathological change of anemia.According to theory of Chinese medical science, for the pathogeny of anemia, with nourishing the liver and kidney, regulating qi-flowing for strengthening spleen, nourshing blood and promoting blood circulation for the rule for the treatment of, carry out dialectical composition of prescription, to reach the object for the treatment of both the principal and secondary aspects of a disease.
Make a general survey of the research direction of world's new drug, the eighties mainly researched and developed single chemicals and preparation thereof in the past, and start after the eighties to develop biotechnology and natural medicinal plants, drug research direction is tending towards multiformity.In conjunction with modern Chinese medicine theory of development, from improving curative effect of medication, reducing the angle of side effect, through carrying out to Chinese medicine ingredients the preparation that screening is extracted and/or compatibility is obtained, its side effect is little, and safety is high, has the advantage that chemical synthetic drug can not be compared.
Summary of the invention
For the deficiency of current anemia clinical treatment medicine, first object of the present invention is to provide a kind of Chinese medicine composition for the treatment of anemia.
Chinese medicine composition of the present invention, is obtained by the raw material of following weight portion: Radix Angelicae Sinensis 10-18 part, Colla Corii Asini 5-8 part, Fructus Jujubae 8-12 part, Caulis Spatholobi 8-12 part, Radix Asparagi 8-12 part, Fructus Schisandrae Chinensis 18-22 part, Rhizoma Chuanxiong 18-22 part, Folium Nelumbinis 8-12 part, Radix Paeoniae Alba 5-8 part, Rhizoma Atractylodis Macrocephalae 5-8 part, Radix Polygalae 12-16 part, Fructus Arctii 5-8 part, Fructus Lycii 8-12 part, Radix Glycyrrhizae 8-12 part.
Chinese medicine composition of the present invention, is obtained by the raw material of following preferred weight part: Radix Angelicae Sinensis 15 parts, 6 parts, Colla Corii Asini, 10 parts, Fructus Jujubae, Caulis Spatholobi 10 parts, Radix Asparagi 10 parts, Fructus Schisandrae Chinensis 20 parts, Rhizoma Chuanxiong 20 parts, 10 parts, Folium Nelumbinis, the Radix Paeoniae Alba 5 parts, the Rhizoma Atractylodis Macrocephalae 5 parts, Radix Polygalae 15 parts, Fructus Arctii 7 parts, Fructus Lycii 10 parts, 10 parts, Radix Glycyrrhizae.
Radix Angelicae Sinensis is considered as by the traditional Chinese medical science key medicine of enriching blood always, for the treatment of anemia.Once someone thought, the blood tonification effect of Radix Angelicae Sinensis may be relevant with containing vitamin B12.Also there are some researches show, single Radix Angelicae Sinensis can not promote the recovery of hemorrhagic anemia animal erythrocyte and hematochrome significantly.Radix Angelicae Sinensis has to enrich blood invigorates blood circulation, menstruction regulating and pain relieving, moisturizes effect of laxation, clinical in diseases such as weight, ulcer sores, injury from falling down after all cards of blood deficiency, asthenia cold abdominalgia, flaccidity syndrome and arthralgia syndrome, numbness of the skin, dryness of the intestine dyschezia, bloody dysentery.
Colla Corii Asini is the glue boiled after the skin unhairing of equine species donkey Equus asinus Linnaeus, has YIN nourishing of enriching blood, moisturizes, effect of hemostasis, for blood deficiency and yellow complexion, and dizzy cardiopalmus, dysphoria and insomnia, the diseases such as xeropulmonary cough.Fructus Jujubae has another name called Fructus Jujubae, dry Fructus Jujubae, Chinese date, originates from China, has the plantation history of more than 8,000 year in China, is just listed in since ancient times one of " five fruits " (chestnut, Fructus Persicae, Lee, Fructus Pruni, Fructus Jujubae).The nutritional labelings such as Fructus Jujubae rich in proteins, fat, saccharide, carotene, vitamin B group, vitamin C, Citrin and calcium, phosphorus, ferrum and cyclic adenosine monophosphate.Wherein ascorbic content comes out at the top in fruit, has the laudatory title of vitamin king.According to external clinical studies show: the patient eating Fructus Jujubae continuously, Health restoration is than eating merely fast more than 3 times of vitamin medicament.Cyclic adenosine monophosphate contained by Fructus Jujubae is the required composition of human body cell energy metabolism, can muscle strength reinforcing, allaying tiredness, blood vessel dilating, increase myocardial contraction, improve myocardial nutrition, to control cardiovascular system diseases have good effect; Chinese medicine theory is thought, Fructus Jujubae has the effects such as tonify deficiency QI invigorating, nourishing blood to tranquillize the mind, invigorating the spleen and regulating the stomach, and Fructus Jujubae has good therapeutic effect to diseases such as chronic hepatitis, liver cirrhosis, anemia, anaphylactoid purpura;
Caulis Spatholobi main product Guangxi, Guangdong, property bitter but sweet flavor temperature, return Liver Channel, promoting the circulation of blood is had to enrich blood, regulating menstruation, the effects such as relaxing muscles and tendons and activating QI and blood in the collateral, can treat that the gynaecopathia such as menoxenia, blockage of menstruation, dysmenorrhea, blood deficiency amenorrhea and rheumatic arthralgia, numb hand and foot, limbs are weak and limp, blood deficiency dull yellowish colored skin etc., and controlling leukopenia also has certain curative effect.
Radix Asparagi is the tuber that Liliaceae asparagus plant has the spindle meat that clusters, and has replenishing YIN and removing heat, moisturizes the effect of promoting the production of body fluid.Cure mainly that pulmonary tuberculosis, bronchitis, diphtheria, pertussis, dryness of the mouth and throat, calentura are thirsty, the disease such as diabetes, constipation due to dry stool; Sore swollen toxin is controlled in external, venom.Modern medicine confirms that Radix Asparagi is containing asparagine, β-sitosterol, steroid saponin, and the composition such as phlegmatic temperament, furfural derivatives, it has significant antibacterial action, antitumor action and Antitussive and Expectorant Effect.
Fructus Schisandrae Chinensis can on to astringe the lung gas, lower nourishing kidney-yin, loses caused chronic cough dyspnea due to deficiency to lung kidney two, can receive the effect of relieving cough and asthma, often joins Radix Codonopsis, Radix Ophiopogonis, Radix Rehmanniae Preparata, Fructus Corni is equivalent uses; This product energy promoting the production of body fluid to quench thirst, astringent or styptic treatment for spontaneous sweating arresting sweating.Often can join Radix Ophiopogonis, the Radix Rehmanniae, Radix Trichosanthis etc. few thirsty with controlling Tianjin; Can join Radix Codonopsis, Radix Ophiopogonis, Fructus Tritici Levis, Concha Ostreae etc. and control the empty hyperhidrosis of body, no matter spontaneous perspiration due to yang insufficiency, night sweat due to yin deficiency, all can apply; Fructus Schisandrae Chinensis energy supplementing the kidney to control the nocturnal, relieving diarrhea with astringents.Control the disease such as emission, frequent micturition, can be equal to Ootheca Mantidis, Semen Cuscutae and use; Control chronic diarrhea, can be equal to Fructus Psoraleae, Semen Myristicae and use.Belong to Compositae herbaceos perennial.
Rhizoma Chuanxiong, original name rhizome of chuanxiong Qiong.A kind of Chinese medicinal plant, is usually used in blood-activating and qi-promoting, wind-expelling pain-stopping, Main Cultivation in Sichuan, Yunnan, Guizhou, Guangxi, the ground such as Hubei.The pungent temperature of Rhizoma Chuanxiong is fragrant dry, walks and does not keep, can go loose, and the up mountain peak that reaches is pushed up; Enter blood system again, descendingly reach the sea of blood.Blood circulation promoting and blood stasis dispelling effect is extensive, the suitable various disease of stagnation of blood stasis; Wind-expelling pain-stopping, effectiveness is excellent, can control the diseases such as wind syndrome of head headache, rheumatic arthralgia.It is gas medicine in blood that former times people calls Rhizoma Chuanxiong, the functions such as pungent loose, the resolving depression of its residence of dangerous speech, sensible, pain relieving.The pungent temperature rise of this product is fallen apart, and all hyperactivity of YANG due to deficiency of YIN and excessive rising of liver-YANG person should not apply; Menorrhagia, anemia of pregnant woman also avoid use.
Folium Nelumbinis is the leaf of nymphaeaceae plant lotus, and national most area is all produced.Folium Nelumbinis bitter in the mouth is pungent micro-puckery, cool in nature, and GUIXIN, liver, spleen channel, delicate fragrance rise loose; There is summer heat relieving and dampness eliminating, spleen invigorating yang invigorating, effect of dissipating blood stasis hemostasis.Cure mainly summer-heat excessive thirst, have a headache dizzy, edema, lack of appetite abdominal distention, dysentery, leucorrhea, proctoptosis, spit blood, epistaxis, spitting of blood, has blood in stool, metrorrhagia, post partum longtime lochia, traumatic blood stasis.Modern medicine confirms that Folium Nelumbinis all has certain therapeutic effect to diarrhoea, edema, hyperlipidemia and dermatosis.
The Radix Paeoniae Alba enters liver, spleen channel, has nourishing blood to suppress the hyperactive liver, pain relieving in slow, and yin fluid astringing receives effect of antiperspirant.Cure mainly the breast abdomen pain over the hypochondriac region, dysentery is suffered from abdominal pain, and spontaneous sweating, fever due to yin deficiency, menoxenia, metrorrhagia, is with inferior disease.
The Rhizoma Atractylodis Macrocephalae is one of Chinese conventional Chinese medicine.It is pungent cool property sweating antipyretic medicine, controls influenza, the disease such as headache, conjunctival congestion, fever of the body, throat, dental bed swell and ache.External can training the mind dysmenorrhoea, skin pruritus, erythra and eczema etc.The Rhizoma Atractylodis Macrocephalae of light friend Greenhouse Fruit Picking is again the fresh vegetable on dining table in the Spring Festival.Clearly good to eat.Usually with the Rhizoma Atractylodis Macrocephalae for tea, clear away heart-fire improving eyesight.Modern medicine proves that the Rhizoma Atractylodis Macrocephalae has very strong antiviral and antibacterial activity, and has certain antiallergic activity.
Radix Polygalae (Radix Polygalae) is conventional Chinese medicine, is recorded in Shennong's Herbal the earliest, is classified as top grade, and is regarded as supporting life key medicine, derives from the dry root of milk wort Radix Polygalae and ovum leaf Radix Polygalae.Warm in nature, bitter in the mouth, pungent, the function of have Fructus Alpiniae Oxyphyllae of calming the nerves, eliminate the phlegm, subsiding a swelling, the insomnia and dreamful sleep caused for disarmony between the heart and kidney, forgetful palpitation with fear, staring spells, expectoration is not well, sore swollen toxin, breast swell and pain.Clinical practice crude Radix Polygalae, Radix Polygalae (processed) and honey polygala root three kinds of decoction pieces specifications, but based on Radix Polygalae (processed).Fructus Arctii is called as Fructus Arctii, and originate in China, Compendium of Material Medica claims " Fructus Arctii " (also known as Fructus Arctii) is 2 years raw herbaceous plant, and its son, its root all can be used as medicine, also edible, and " Bencao Jingshu " is called " loose wind is except thermal detoxification three key medicine ".Prior art proves that it has significant anti-bacteria and anti-virus effect, and the immunocompetence of the remarkable enhancing body of energy.Radix Polygalae and Fructus Arctii two kinds of medicines are used in conjunction, can the immunocompetence of remarkable enhancing body.
The flat sweet in the mouth of Fructus Lycii, enter liver, kidney channel, there is effect of replenishing YIN and blood, nourishing the liver and kidney, replenishing vital essence to improve eyesight, be usually used in treating that Liver and kidney is deficient, the disease such as soreness of the waist and knees, dizziness, tinnitus, seminal emission caused by asthenia of essence and blood, to deficiency of the liver and kindey, essence and blood can not on disease curative effects such as, visual deterioration dim-sighted in the eyes caused by order of helping especially good.Modern pharmacological research shows, Fructus Lycii contains the composition such as carotene, betanin, vitamin A, vitamin B1, vitamin B2, vitamin C and calcium, phosphorus, ferrum, there is the effect strengthening leukocyte activity, suppress fat deposition, promotion hepatocyte new life in hepatocyte, evident in efficacy to chronic hepatitis, central serous chorioretinopathy, optic atrophy etc., also can blood pressure lowering, blood sugar lowering, blood fat reducing.Due to Fructus Lycii effect significantly and mild in medicine property and, so praised highly the good medicine for building body, slow down aging by successive dynasties famous expert.
Radix Glycyrrhizae sweet in the mouth is sweet, and property is gentle, enters the heart, spleen, lung, stomach four warp.Raw with cooler, can eliminating fire and detoxication, relieving spasm to stop pain; Process with partially warm, can fall apart exterior cold, invigorating the spleen and replenishing QI.In addition, Radix Glycyrrhizae is also good at being in harmonious proportion the property of medicine, separates the poison of hundred medicines.Western modern medicine haircut is existing, and Radix Glycyrrhizae agent has the function of antiinflammatory and the reflection of resistance state, therefore in doctor trained in Western medicine clinically mainly as demulcent.Relieving cough, eliminates the phlegm, treatment pharyngalgia laryngitis; Radix Glycyrrhizae or enoxolone have the effect of desoxycortone class, have good effects to chronic adrenocortical hypofunction; Glycyrrhiza preparation can promote stomach mucus to be formed and secretion, extends the epithelial cell life-span, has anti-inflammatory activity, be usually used in the treatment of chronic ulcer and duodenal ulcer; The flavone of Radix Glycyrrhizae has antiinflammatory, spasmolytic and antiacid effect; Radix Glycyrrhizae is also one of primary raw material of rendan mini-pills.
The method preparing Chinese medicine composition of the present invention is as follows: each medical material getting above-mentioned components by weight percent, adds the 5-15 water doubly of medical material gross weight, soaks 10-60 minute, decoct 1-4 time, each 1-3 hour, filter, merging filtrate, filtrate reduced in volume is to the extractum of relative density 1.05-1.25, and this relative density is testing result at 60 c, and adding ethanol to alcohol content is 60-90%(v/v), leave standstill 24 hours, get supernatant, reclaim ethanol to concentrated, to obtain final product.The above-mentioned Chinese medicine composition of the present invention can be prepared into pharmaceutical preparation conventional clinically further, is preferably mixture, tablet or capsule.
The present invention also discloses a kind of purposes of above-mentioned Chinese medicine composition, i.e. the purposes of above-mentioned Chinese medicine composition in preparation treatment or prevention anemia medicine.We find: in the experiment of animal Anemia model, Chinese medicine composition of the present invention, except significantly can increasing the erythrocyte of Anemia model rat and the effect of hemoglobin, also has significant leukocyte regulating action.During the treatment of Chinese medicine composition of the present invention to chronic inflammatory disease anemia (ACD), chronic inflammatory disease leukocyte can be reduced and raise, thus fundamentally suppress the inducement of anemia.Have therapeutical effect to the hemolytic anemia caused by acetylphenylhydrazine, mechanism may be the antioxidation of enhancing body, reduces acetylphenylhydrazine and plays a role to erythrocytic destruction.Different from current clinical treatment aplastic anemia medicine, Chinese medicine composition of the present invention increases erythropoiesis by activated bone marrow hemopoietic function and improves content of hemoglobin, and androgen can be avoided to treat the untoward reaction brought.
In a word, the present invention compared with prior art, has the activity for the treatment of anemia very well, and can the present invention be pure Chinese medicinal preparation, to human body particularly to liver avirulence.When the present invention uses as anemia treatment agent, drug effect is comprehensive, has not only embodied significant antiinflammatory bactericidal effect, and can significantly alleviate anemia pain; Can regulate the immunocompetence of body while eliminating Anemia, sb.'s illness took a favorable turn can to make rapidly Anemic patients, plays the therapeutic effect for the treatment of both the principal and secondary aspects of a disease; And Chinese medicine composition preparation of the present invention is simple, and substantially nontoxic, raw material is easy to get, and is suitable for popular use, has good application prospect.
Detailed description of the invention
Further describe the present invention below by way of detailed description of the invention, but the present invention is not limited only to following examples.Within the scope of the invention or not departing from content of the present invention, spirit and scope, Chinese medicine composition of the present invention is suitably improved, replaces the identical component of effect, will become apparent to those skilled in the art that they are all deemed to be included within scope of the present invention.
part I, the preparation of Chinese medicine composition of the present invention
embodiment 1 Chinese medicine composition mixture of the present invention
Prescription: Radix Angelicae Sinensis 15 parts, 6 parts, Colla Corii Asini, 10 parts, Fructus Jujubae, Caulis Spatholobi 10 parts, Radix Asparagi 10 parts, Fructus Schisandrae Chinensis 20 parts, Rhizoma Chuanxiong 20 parts, 10 parts, Folium Nelumbinis, the Radix Paeoniae Alba 5 parts, the Rhizoma Atractylodis Macrocephalae 5 parts, Radix Polygalae 15 parts, Fructus Arctii 7 parts, Fructus Lycii 10 parts, 10 parts, Radix Glycyrrhizae.
Preparation method: each medical material getting above-mentioned components by weight percent, adds the water of 5 times of medical material gross weight, soaks 30 minutes, decoct 2 times, each 2 hours, filter, merging filtrate, filtrate reduced in volume is to the extractum of relative density 1.1, and this relative density is testing result at 60 c, adding ethanol to alcohol content is 75%(v/v), leave standstill 24 hours, get supernatant, recovery ethanol concentrates, and adds water to 1000ml, stirs evenly, subpackage, flowing steam sterilization 35min, obtains mixture.
embodiment 2 Chinese medicine composition tablet of the present invention
Prescription: Radix Angelicae Sinensis 15 parts, 6 parts, Colla Corii Asini, 10 parts, Fructus Jujubae, Caulis Spatholobi 10 parts, Radix Asparagi 10 parts, Fructus Schisandrae Chinensis 20 parts, Rhizoma Chuanxiong 20 parts, 10 parts, Folium Nelumbinis, the Radix Paeoniae Alba 5 parts, the Rhizoma Atractylodis Macrocephalae 5 parts, Radix Polygalae 15 parts, Fructus Arctii 7 parts, Fructus Lycii 10 parts, 10 parts, Radix Glycyrrhizae.
Preparation method: each medical material getting above-mentioned components by weight percent, adds the water of 10 times of medical material gross weight, soaks 60 minutes, decoct 1 time, each 1 hour, filter, merging filtrate, filtrate reduced in volume is to the extractum of relative density 1.25, and this relative density is testing result at 60 c, adding ethanol to alcohol content is 80%(v/v), leave standstill 24 hours, get supernatant, reclaim ethanol to concentrated, vacuum drying, granulation, tabletting and get final product.
embodiment 3 Chinese medicinal composition capsules of the present invention
Prescription: Radix Angelicae Sinensis 15 parts, 6 parts, Colla Corii Asini, 10 parts, Fructus Jujubae, Caulis Spatholobi 10 parts, Radix Asparagi 10 parts, Fructus Schisandrae Chinensis 20 parts, Rhizoma Chuanxiong 20 parts, 10 parts, Folium Nelumbinis, the Radix Paeoniae Alba 5 parts, the Rhizoma Atractylodis Macrocephalae 5 parts, Radix Polygalae 15 parts, Fructus Arctii 7 parts, Fructus Lycii 10 parts, 10 parts, Radix Glycyrrhizae.
Preparation method: each medical material getting above-mentioned components by weight percent, adds the water of 8 times of medical material gross weight, soaks 45 minutes, decoct 4 times, each 1.5 hours, filter, merging filtrate, filtrate reduced in volume is to the extractum of relative density 1.2, and this relative density is testing result at 60 c, adding ethanol to alcohol content is 90%(v/v), leave standstill 24 hours, get supernatant, reclaim ethanol to concentrated, vacuum drying, granulates, encapsulated and get final product.
part II, the pharmacodynamics of Chinese medicine composition of the present invention is investigated
embodiment 4 Chinese medicine composition of the present invention is to the therapeutical effect of chronic inflammatory disease Anemia model mice
1. experimental technique
ICR mice 60, male and female half and half, body weight (20 ± 2) g, The 2nd Army Medical College Experimental Animal Center provides, ICR mice is divided into 6 groups at random by sex, body weight, often organizes 10, male and female half and half, each group is respectively negative control group, model group, positive controls, and Chinese medicine composition of the present invention divides basic, normal, high dosage group.
Laboratory animal modeling: test the 1st day under etherization subcutaneous aseptic injection air of mouse back, 3ml/ is only; The 2nd day complete Freund's adjuvant of injection containing 0.1% Oleum Tiglii in air bag, 0.5ml/ is only; From the 2nd day, each group of mice was by table one administration (5ml/kg); Air bag forms the 6th day, and anesthetized mice posterior orbit venous plexus gets blood, the anticoagulant of EDTA-2K anticoagulant tube, surveys routine blood test.
The grouping of table 1 chronic inflammatory disease anemia mice and administration table
2. experimental result
The each administration group of table 2 is to analysis of Hematology Changes result after the treatment of Anemia model mice
Compare with normal group,
# p< 0.05,
## p< 0.01; Compare with model group,
* p< 0.05,
* p< 0.01.
By table 2 experimental result, compared with normal group, model group WBC quantity significantly increases, RBC, HGB and HCT significantly reduce (
p< 0.01), show successfully to copy inflammation Anemia model.Medication is after 5 days, Chinese medicine composition of the present invention each dosage group has good therapeutic effect to the struvite Anemia model of mice, RBC, HGB and HCT all have rising in various degree, in Chinese medicine composition especially of the present invention RBC, HGB and HCT of dosage group and high dose group and model group comparison sheet reveal extremely significant difference (
p< 0.01), all close to or reach the measured value of normal mouse, show that the treatment of Chinese medicine composition of the present invention to chronic inflam matory anemia has dose dependent.In addition, each dosage group of Chinese medicine composition of the present invention all can reduce WBC quantity, embodies significant anti-inflammatory activity, and presents dose dependent.Although the concrete mechanism that Chinese medicine composition of the present invention acts on inflammation anemia is not clear, but this experiment shows that Chinese medicine composition of the present invention not only can play the effect for the treatment of anemia by the regulating action to mice body, also significantly alleviate mice inflammatory reaction by antiinflammatory action, thus the inducement of fundamentally inflammation-inhibiting anemia.
embodiment 5 Chinese medicine composition of the present invention is to the therapeutical effect of Induced Aplastic Anemia Mice model
1 experimental technique:
ICR mice totally 72, male and female half and half, body weight 20 ± 2g, The 2nd Army Medical College Experimental Animal Center provides.Mice is divided into 6 groups at random by body weight, sex, and often organize 12, male and female half and half, each group is respectively normal group, model group, positive controls, the basic, normal, high dosage group of Chinese medicine composition of the present invention.Each group of mice presses table 3 administration 14 days, model control group and each administration group are respectively at administration the 2nd day and the 5th day subcutaneous injection acetylphenylhydrazine 20mg/kg, 40mg/kg, from the 5th day every day intraperitoneal injection of cyclophosphamide 40mg/kg, continuous 4 days, the capacity normal saline such as Normal group injection.2h after last administration, Animal Anesthesia is put to death and is got blood survey routine blood test, observes platelet (PLT), leukocyte (WBC), erythrocyte (RBC), hemoglobin (HGB) value and reticulocyte (RET) counting.
The grouping of table 3 Induced Aplastic Anemia Mice and administration table
2 experimental results
The each administration group of table 4 is to the hemanalysis result after aplastic anemia model mice treatment
Compare with normal group,
# p< 0.05,
## p< 0.01; Compare with model group,
* p< 0.05,
* p< 0.01.
From table 4, compared with normal group, model group RBC, HGB and HCT and Normal group significantly reduce (
p< 0.01), illustrate and successfully set up aregeneratory type Anemia model; Medication, after 14 days, is compared with model group, the platelet count of Chinese medicine composition of the present invention each dosage group mice and the obvious comparatively model group mice of leukocyte count are increased (
p< 0.05 or
p< 0.01), show model with aplastic anemia mouse peripheral blood platelet count, RBC number and content of hemoglobin that Chinese medicine composition of the present invention obviously can not only increase cyclophosphamide and acetylphenylhydrazine and causes, embody the therapeutical effect to aregeneratory type anemia, and this therapeutic effect presents dose dependent.Chinese medicine composition of the present invention significantly can also increase quantity of leucocyte, improves the immunity of body.As can be seen here, Chinese medicine composition of the present invention has good therapeutic effect to aplastic anemia in mice.
embodiment 6 Chinese medicine composition of the present invention is to the clinical therapeutic efficacy of anemia
For showing this arcanum thing main efficacy results, selecting 100 routine patients with various kinds of anemia cases to take medicine of the present invention and seeing
Examine, be a course for the treatment of with 30 days, 2-3 the course for the treatment of, carry out systems inspection respectively.
1, physical data
Choose Anemic patients 200 example in year May in February, 2010 to 2012, wherein man 80 example, female 120 example, age 18-76 year, the mean age (52.7 ± 3.4) year.The course of disease 10 days to 20 years, wherein macrocytic anemia 86 example, positive cellulous anemia 49 example, small cell anemia 65 example.Above case is all made a definite diagnosis through routine blood test, peripheral blood film, reticulocyte count or bone marrow aspiration, marrow cell coating plate classification etc. inspections.Be divided into observation group and each 100 examples of matched group at random, the physical data such as two groups of patient ages, sex, the course of disease, state of an illness are compared, and no significant difference (p > 0.05), has comparability.
2, medication
Observation group's employing is carried out treatment prescription and is: Radix Angelicae Sinensis 15g, Colla Corii Asini 6g, Fructus Jujubae 10g, Caulis Spatholobi 10g, Radix Asparagi 10g, Fructus Schisandrae Chinensis 20g, Rhizoma Chuanxiong 20g, Folium Nelumbinis 10g, Radix Paeoniae Alba 5g, Rhizoma Atractylodis Macrocephalae 5g, Radix Polygalae 15g, Fructus Arctii 7g, Fructus Lycii 10g, Radix Glycyrrhizae 10g, make capsule, every day 3 times, each 9-12 gram.Matched group adopts Oral Iron Preparations to treat, every day 2 times, each 3g.
3, curative effect determinate standard
Cure: clinical symptoms and sign disappear or significantly improve situation, and routine blood test, peripheral blood film, reticulocyte count or bone marrow aspiration, marrow cell coating plate classification etc. inspections are recovered or are clearly better.
Improve: clinical symptoms and sign comparatively before take a turn for the better, the Index for examinations such as routine blood test, peripheral blood film, reticulocyte count or bone marrow aspiration, bone marrow are thin, the classification of born of the same parents' smear are improved.
Invalid: without taking a turn for the better before clinical symptoms and sign, routine blood test, peripheral blood film, reticulocyte count or bone marrow aspiration, marrow cell coating plate classification comparatively.
4, therapeutic outcome
Statistical analysis is carried out: in 200 routine patients, cure 124 examples (62.0%) through system clinical observation, improve 66 examples (33.0%), invalid 10 examples (5.0%), total effective rate 95.0%, be showed no any untoward reaction, prompting obtains comparatively significant clinical efficacy.
Claims (6)
1. treat a Chinese medicine composition for anemia, it is characterized in that being obtained by the raw material of following weight portion: Radix Angelicae Sinensis 15 parts, 6 parts, Colla Corii Asini, 10 parts, Fructus Jujubae, Caulis Spatholobi 10 parts, Radix Asparagi 10 parts, Fructus Schisandrae Chinensis 20 parts, Rhizoma Chuanxiong 20 parts, 10 parts, Folium Nelumbinis, the Radix Paeoniae Alba 5 parts, the Rhizoma Atractylodis Macrocephalae 5 parts, Radix Polygalae 15 parts, Fructus Arctii 7 parts, Fructus Lycii 10 parts, 10 parts, Radix Glycyrrhizae.
2. treat the Chinese medicine composition of anemia as claimed in claim 1, it is characterized in that: described Chinese medicine composition is mixture, tablet or capsule.
3. the preparation method of the Chinese medicine composition for the treatment of anemia as claimed in claim 1, it is characterized in that comprising the following steps: get each medical material, add the 5-15 water doubly of medical material gross weight, soak 10-60 minute, decoct 1-4 time, each 1-3 hour, filter, merging filtrate, filtrate reduced in volume is to the extractum of relative density 1.05-1.25, this relative density is testing result at 60 c, adding ethanol to alcohol content is 60-90%v/v, leaves standstill 24 hours, gets supernatant, reclaim ethanol to concentrated, to obtain final product.
4. treat the purposes of Chinese medicine composition in preparation treatment or prevention anemia medicine of anemia as claimed in claim 1.
5. treat the purposes of the Chinese medicine composition of anemia as claimed in claim 4, it is characterized in that: described anemia is chronic inflammatory disease anemia.
6. treat the purposes of the Chinese medicine composition of anemia as claimed in claim 4, it is characterized in that: described anemia is aplastic anemia.
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