CN104147166B - Septicemia initial stage refreshing and detoxicating drink and method for making - Google Patents
Septicemia initial stage refreshing and detoxicating drink and method for making Download PDFInfo
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Abstract
The invention discloses a kind of refreshing and detoxicating drink for the treatment of the septicemia initial stage, be prepared from primarily of following bulk drugs, be weight portion: Radix Saposhnikoviae 3-9, Herba Schizonepetae 4-8, Radix Angelicae Dahuricae 6-12, Fructus Garciniae oblongifoliae 3-6, Rhizoma Et Radix Notopterygii 2-6, Rhizoma Coptidis 4-12, Fructus Forsythiae 6-15, Radix Scutellariae 8-16, Flos Lonicerae 20-35, Herba Agerati Conyzoidis 4-9, Radix Paeoniae Alba 6-12 Aralia continentalis.Kitagawa 2-6, Poria cum Radix Pini 8-15, Flos Sophorae Immaturus 3-6, Radix Platycodonis 6-15, Herba Catharanthi Rosei 4-9, Radix Glycyrrhizae 4-9.The present invention has refreshing and detoxicating, effect of removing damp and stopping pain, and has no side effect, and preparation is simple, has good therapeutic effect for the septicemia initial stage.
Description
Technical field
The present invention relates to traditional Chinese medicine field, particularly relate to a kind of refreshing and detoxicating soup drink and method for making thereof for the treatment of the septicemia initial stage.
Background technology
Septicemia refers to that pathogenic bacterium or conditioned pathogen invade blood circulation, and raised growth breeding in blood, produces toxin and other metabolites and the systemic infection that causes.Different and different with the power of resistance with the kind of pathogenic bacterium, quantity, virulence and children age.It mostly occurs in the crowd of immunity recession, as suffered from malnutrition, anemia, diabetes and cirrhotic patient.Septicemia itself there is no special clinical manifestation, the performance that the septicemia initial stage is seen is found in other actute infection, as recurrent fear of cold is even shivered with cold, high heat can be tension and relaxation type or batch-type, erythra based on petechia, the arthralgia of involving large joint, slight hepatosplenomegaly, severe one can have mind change, myocarditis, septic shock, disseminated inravascular coagulation (DIC), respiratory distress syndrome etc.Be main to it mainly with antibacterial therapy, clinical treatment septicemia often uses antibiotic, if but antibiotic usage is improper, and easily have side effects, hair conditioning is poor, and it is more suitable for the treatment of emergency case.The idea of this sick lay special stress on organic conception of Chinese traditional treatment, dialectical treatmert, regulating yin and yang, too many levels conditioning, many use eliminating pestilence and relieving toxicity drinks, cow-bezoar bolus for resurrection, antiphlogistic forsythiae ball, YINHUANG PIAN etc.
Publication number CN103463191A(application number 201310363125.6) Chinese patent literature disclose a kind of medicinal preparation for oral administration and preparation technology of bacterial septicemia, this medicinal preparation for oral administration is prepared from by arasaponin, Radix Scutellariae total glucosides, the fragrant gracilis polysaccharide in the East Sea, trimethoprim, Fructus Momordicae extract, paddy Fructus Foeniculi extract.Publication number CN103610984A(application number 201310647450.5) Chinese patent literature disclose a kind of oral liquid and preparation method for the treatment of septicemia, this oral liquid is made up of Herba Taraxaci, Radix Angelicae Pubescentis, Semen Arecae, Rhizoma Alocasiae Cucullatae (Rhizoma Alocasiae Macrorrhizae), Herba Lophatheri, Folium Nerviliae fordii, Ramulus Uncariae Cum Uncis, Semen Iridis, Fructus Ulmus preparatium, Radix Cirsii Japonici, Radix Arnebiae (Radix Lithospermi), Herba Artemisiae Annuae, Radix Gentianae, Caulis Bambusae Germinatus, Herba Violae and Radix Sophorae Flavescentis.Publication number CN101698078A(application number 200910172537.5) Chinese patent literature disclose a kind of Chinese medicine for the treatment of septicemia, this Chinese medicine comprises following bulk drugs: Radix Notoginseng, Radix Arnebiae (Radix Lithospermi), Radix Angelicae Sinensis, Cornu Saigae Tataricae, Sanguis Draxonis, Flos Sophorae, Cornu Bubali powder, Fel Ursi, Fructus Mume, Flos Lonicerae, Polyporus, Fructus Tsaoko, Rhizoma Alismatis, Cortex Magnoliae Officinalis, Fructus Aurantii Immaturus, the Radix Polygoni Multiflori, the Radix Paeoniae Alba, Fructus Lycii, the Radix Rehmanniae, Radix Rehmanniae Preparata, Fructus Mori, Colla Corii Asini, Colla cornus cervi, Colla Plastri Testudinis, Cortex Lycii, Cortex Moutan, Bulbus Lilii, Rhizoma Polygonati Odorati, Fructus Ligustri Lucidi, Fructus Schisandrae Chinensis, Herba Dendrobii, Herba Ecliptae, Carapax Trionycis, Fructus Rubi, Ootheca Mantidis, Radix Bupleuri, Rhizoma Cyperi, Semen Nelumbinis, Plumula Nelumbinis, Radix Codonopsis, the Radix Astragali, Herba Patriniae, Caulis Sargentodoxae, Radix Glycyrrhizae, Rhizoma Dioscoreae, Endothelium Corneum Gigeriae Galli, Massa Medicata Fermentata, Fructus Hordei Germinatus, ancient bud, Fructus Crataegi, Radix Aucklandiae (Radix Vladimiriae).
Chinese medicine has achieved good curative effect in treatment primary disease, but during the initial stage of Chinese traditional treatment septicemia for many years disease, all because the choosing of medicament categories, the reason such as unreasonable of arranging in pairs or groups make clinical experiment effect not remarkable, the treatment causing septicemia early stage can not reach very desirable effect, and Chinese medicine is to be further improved in addition to the curative effect at septicemia initial stage.
Summary of the invention
For the deficiencies in the prior art, the object of this invention is to provide a kind of refreshing and detoxicating drink and the method for making thereof of preparing the treatment septicemia initial stage of simple, taking convenience.This refreshing and detoxicating is drunk determined curative effect and is had no side effect.
Technical scheme of the present invention is:
The refreshing and detoxicating drink at treatment septicemia initial stage, is prepared from by following bulk drugs, is weight portion: Radix Saposhnikoviae 3-9, Herba Schizonepetae 4-8, Radix Angelicae Dahuricae 6-12, Fructus Garciniae oblongifoliae 3-6, river Qiang 2-6, Rhizoma Coptidis 4-12, Fructus Forsythiae 6-15, Radix Scutellariae 8-16, Flos Lonicerae 20-35, Herba Agerati Conyzoidis 4-9, Radix Paeoniae Alba 6-12 Aralia continentalis.Kitagawa 2-6(is preferred, Aralia continentalis.Kitagawa 2.5-5.5; Be more preferably, Aralia continentalis.Kitagawa 4.8), Poria cum Radix Pini 8-15, Flos Sophorae Immaturus 3-6, Radix Platycodonis 6-15, Herba Catharanthi Rosei 4-9, Radix Glycyrrhizae 4-9.
In preferred scheme, Radix Saposhnikoviae 4-8, Herba Schizonepetae 5-7, Radix Angelicae Dahuricae 8-10, Fructus Garciniae oblongifoliae 4-5, Rhizoma Et Radix Notopterygii 3-5, Rhizoma Coptidis 6-10, Fructus Forsythiae 9-12, Radix Scutellariae 10-14, Flos Lonicerae 25-30, Herba Agerati Conyzoidis 5-8, Radix Paeoniae Alba 8-10 Aralia continentalis.Kitagawa 3-5, Poria cum Radix Pini 9-14, Flos Sophorae Immaturus 4-5, Radix Platycodonis 9-12, Herba Catharanthi Rosei 5-8, Radix Glycyrrhizae 5-8.
Be more preferably, Radix Saposhnikoviae 6, Herba Schizonepetae 6, the Radix Angelicae Dahuricae 9, Fructus Garciniae oblongifoliae 4.5, Rhizoma Et Radix Notopterygii 4, Rhizoma Coptidis 8, Fructus Forsythiae 10.5, Radix Scutellariae 12, Flos Lonicerae 22.5, Herba Agerati Conyzoidis 6.5, the Radix Paeoniae Alba 9, Aralia continentalis.Kitagawa 4, Poria cum Radix Pini 11.5, the Flos Sophorae Immaturus 4.5, Radix Platycodonis 10.5, Herba Catharanthi Rosei 6.5; Radix Glycyrrhizae 6.5.
The preparation method of described refreshing and detoxicating drink is:
(1) Radix Saposhnikoviae to be placed in pot micro-stir-fry to buff, to take out and dry in the air cool to room temperature, make Radix Saposhnikoviae (parched);
(2) by Radix Saposhnikoviae (parched), Herba Schizonepetae, the Radix Angelicae Dahuricae, Rhizoma Coptidis, Fructus Forsythiae, Radix Scutellariae, Herba Agerati Conyzoidis, the Radix Paeoniae Alba, Aralia continentalis.Kitagawa, Poria cum Radix Pini, Herba Catharanthi Rosei, Radix Glycyrrhizae decontamination, clean and put into container, add distilled water dipping, then boil a turn little fire to decoct 20-30 minute (preferably 25 minutes), filter and collect supernatant, leave recrement, recrement is watered big fire again and is fried open, turn after little fire is decocted and leach supernatant, after twice supernatant mix homogeneously, for subsequent use;
(3) get Fructus Garciniae oblongifoliae and Flos Sophorae Immaturus decontamination, microwave drying, pulverizes and sieves, and obtains traditional Chinese medicine fine powder, for subsequent use;
(4) Flos Lonicerae, Rhizoma Et Radix Notopterygii and Radix Platycodonis decontamination are cleaned, dry, add 80% ethanol, soak filter, repeat soak once filter, merge twice filtrate, filtrate be concentrated into relative density 1.19(60 DEG C) thick paste, for subsequent use;
(6) by supernatant, fine powder and the thick paste mix homogeneously obtained by above-mentioned steps (2)-(4), sterilizing subpackage.
The preparation method of described refreshing and detoxicating drink, in step (2), the amount of adding distil water is the 6-8 of medical material weight doubly (preferred 6.5-7.5 doubly, is more preferably 7 times).
The preparation method of described refreshing and detoxicating drink, in step (2), distilled water dip time is 2-4 hour (preferred 2.5-3.5 hour is more preferably 3 hours).
The preparation method of described refreshing and detoxicating drink, crossing grit number in step (2) is 70-110 order (preferred 80-100 order, is more preferably 90 orders)
The preparation method of described refreshing and detoxicating drink, in step (5), the amount of 80% ethanol is the 4-8 of medical material weight doubly (preferred 5-7 doubly, is more preferably 6 times).
The preparation method of described refreshing and detoxicating drink, in step (5), soak time is 16-20 hour (preferred 17-19 hour is more preferably 18 hours).
Present invention also offers the described application of refreshing and detoxicating drink when treating the septicemia initial stage.
The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:
Radix Saposhnikoviae: nature and flavor: pungent, sweet, tepor.Gui Jing: return bladder, lung, spleen, Liver Channel.Effect: expelling pathogenic wind from the body surface, removing dampness to relieve pain.Cure mainly: for affection of exogenous wind-cold, headache general pain, rheumatic arthralgia.
Herba Schizonepetae: nature and flavor: micro-hardship, pungent, tepor.Gui Jing: return lung, Liver Channel.Effect: dispel the wind, induces sweat, rash, hemostasis.Cure mainly: for cold, fever, headache, cough, laryngopharynx swelling and pain, measles, carbuncle, skin ulcer scabies, epistaxis, spit blood, have blood in stool, metrorrhagia, rubella, skin infection from the beginning of.
The Radix Angelicae Dahuricae: nature and flavor: pungent, temperature.Gui Jing: return lung, thigh, stomach warp.Effect: expelling wind and removing dampness, understand things pain-stopping, detumescence and apocenosis.Cure mainly: for headache of catching a cold, nasal obstruction, nasal sinusitis.
Fructus Garciniae oblongifoliae: base is former: be the fruit of Guttiferae Garcinia plant Fructus Garciniae oblongifoliae and south of the Five Ridges Cortex Garciniae.Composition: Fructus Garciniae oblongifoliae is containing bisflavone glycosides: 3,8 "-binaringenin-7 "-O-glucoside, good fortune tree glycosides, fukugiside, Xanthochymuside etc.Nature and flavor: Yao Kecheng " food book on Chinese herbal medicine ": " sweet in the mouth, flat." effect: Yao Kecheng " food book on Chinese herbal medicine ": " regulating fluid apssage, slakes thirst and help produce saliva for main heat clearing away, sharp hundred arteries and veins, and expelling summer-heat disappears wine.Cure mainly: for telling against not eating, obstruction and rejection is closed and refused to lead to, insufficiency of the spleen sagging, anus pendant is de-not to be received.Heat clearing away, cool large intestine, removes hematocele, and sharp knowledge, controls cough with dyspnea.”
Rhizoma Et Radix Notopterygii (river Qiang): nature and flavor: pungent, bitter, temperature.Gui Jing: return bladder, kidney channel.Effect: cold expelling dispels the wind, removing damp and stopping pain.Cure mainly: anemofrigid cold, headache stiffness of the nape, rheumatic arthralgia, aching pain in should and back.
Rhizoma Coptidis (Rhizoma Coptidis): nature and flavor: bitter, cold.Gui Jing: GUIXIN, spleen, stomach, liver, gallbladder, large intestine channel.Effect: heat clearing and damp drying, eliminating fire and detoxication.Cure mainly: for damp and hot feeling of fullness, vomiting acid regurgitation, dysentery, jaundice, unconsciousness due to high fever, hyperactivity of heart-fire, dysphoria and insomnia, heat in blood tells nosebleed, conjunctival congestion, and toothache, quenches one's thirst.
Fructus Forsythiae: nature and flavor: bitter, is slightly cold.Gui Jing: return lung, the heart, small intestine meridian.Effect: heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, dispelling wind and heat pathogens.Cure mainly: for carbuncle, scrofula, acute mastitis, erysipelas, anemopyretic cold, epidemic febrile disease from the beginning of, warm people battalion, high hot excessive thirst, coma sends out speckle, the puckery pain of pyretic stranguria.
Radix Scutellariae: nature and flavor: bitter, cold.Gui Jing: return lung, gallbladder, spleen, large intestine, small intestine meridian.Effect: heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive.Cure mainly: for hygropyrexia, heat-damp in summer, vomiting and nausea uncomfortable in chest, damp and hot feeling of fullness, dysentery, jaundice, cough due to lung-heat, high hot excessive thirst, heat in blood tells nosebleed, carbuncle sore tumefacting virus, frequent fetal movement.
Flos Lonicerae (Flos Lonicerae): nature and flavor: sweet, cold.Gui Jing: return lung, the heart, stomach warp.Effect: heat-clearing and toxic substances removing, dispelling wind and heat pathogens.Cure mainly: treat skin ulcer for carbuncle, sore throat, erysipelas, toxic-heat and blood stasis, anemopyretic cold, epidemic febrile disease is generated heat.
Herba Agerati Conyzoidis: be the herb of Compositae Ageratum plant Ageratum conyzoides.Composition: herb contains flavonoid, alkaloid, triterpenoid compound, volatile oil.Aerial parts I have chromene class.Pharmacology: have stimulation to cardiac muscle, has inhibitory action to smooth muscle, has the effect of anti-inflammatory and antalgic, has antibacterial effect.Nature and flavor: micro-hardship, pungent, cool.Effect: heat-clearing and toxic substances removing, hemostasis, pain relieving.
The Radix Paeoniae Alba (Radix Paeoniae Alba): nature and flavor: bitter in the mouth, acid, be slightly cold.Gui Jing: return liver, spleen channel.Effect: suppressing the hyperactive liver pain relieving, nourishing blood for regulating menstruation, astringing YIN to stop sweating.Cure mainly: for have a headache dizzy, hypochondriac pain, stomachache, limb pain twin, blood deficiency and yellow complexion, menoxenia, spontaneous perspiration, night sweat.
Aralia continentalis.Kitagawa: base is former: be the root and rhizome of Wu Jia Ke Cortex araliae chinensis platymiscium Aralia continentalis.Kitagawa.Containing Kaurenic acid, dammara alkyd, Aralia continentalis.Kitagawa acid, daucosterol, cupreol, ferulic acid and caffeic acid in the root of composition: Aralia continentalis.Kitagawa.Pharmacology: the 1. effect Aralia continentalis.Kitagawa volatile oil of couple central nervous system has obvious sedation, and Aralia continentalis.Kitagawa extract also has obvious calmness, convulsion, analgesia and refrigeration function.2. antiinflammatory action Aralia continentalis.Kitagawa is to humoral immunization and cellular immunization, and all has obvious inhibitory action to the release of allergy late inflammatory medium and proinflammatory effect.Nature and flavor: pungent, bitter, wet.Effect: expelling wind and removing dampness, invigorates blood circulation, removing toxic substances.Cure mainly: for anemofrigid-damp arthralgia, soreness of waist and knee joint, headache, toothache, traumatic pain, carbuncle.
Poria cum Radix Pini: base is former: for Polyporaceae crouches the sclerotium of hole platymiscium Poria, original kind is rudimentary plant, is the fungus colonized on pinaster.Medicinal effects is the white portion entertaining Radix Pini massonianae in the middle of dry sclerotia body.Nature and flavor: sweet, light flat.Gui Jing: GUIXIN, spleen channel.Effect: have eliminating dampness by diuresis, spleen invigorating, mind calming.Cure mainly: for phlegm retention, edema, dysuria, have loose bowels, cardiopalmus, dizzy.
The Flos Sophorae Immaturus: nature and flavor: sweet is flat, cold and cool.Gui Jing: return liver, large intestine channel.Effect: cooling blood for hemostasis, purging liver-fire.Cure mainly: for having blood in stool, hemorrhoidal bleeding, dysentery, metrorrhagia, haematemesis, epistaxis, liver-heat conjunctival congestion, have a headache dizzy.
Radix Platycodonis: nature and flavor: bitter, pungent is flat.Gui Jing: return lung meridian.Effect: lung qi dispersing, sore-throat relieving, eliminates the phlegm, evacuation of pus.Cure mainly: for cough with copious phlegm, uncomfortable in chest smooth, pharyngalgia, hoarseness, lung abscess vomiting pus, skin infection difficulty in discharging of pus.
Herba Catharanthi Rosei: base is former: be Apocynaceae periwinkle plant Herba Catharanthi Rosei, the herb of yellow Herba Catharanthi Rosei.Composition: plant containing indoles alkaloid more than 70 in Herba Catharanthi Rosei, comprise vinblastine, vincristine, lochnericine, lochnericine, remove acetyl vindorosine, vincaleucoblastine, Changchun Buddhist nun is fixed, lochnerinine etc.Root containing alkaloid, comprises that 9-methoxycorynantheidine., akuammicine, west, Changchun are fixed, lochnerivine, cavineine sulfate, sulphuric acid stay around western language alkali, and ammocalline, sulphuric acid group is around raw etc.Pharmacology: 1. antitumor action Herba Catharanthi Rosei contains vinblastine, vincristine, leurosine, leurosidine have obvious antitumor action.2. Antitumor Mechanism Herba Catharanthi Rosei antitumor action is directly relevant to the high-affinity of tubulin binding with medicine, suppress nucleic acid synthesis be it another mechanism.No matter 3. blood pressure lowering and vasodilative effect catharanthus roseus total alkaloids gavage, intramuscular injection or quiet note all have hypotensive effect to anesthetized dog, also has the effect of expansion coronary vasodilator.4. the water extract of blood sugar lowering and effect for reducing blood fat this product leaf has normal or alloxan diabetes rabbit and dog and reduces blood glucose effect.Nature and flavor: bitter, cold, poisonous.Effect: detoxicating and fighting cancer, heat clearing away suppressing the hyperactive liver.Cure mainly: for multiple cancerous protuberance, hypertension, carbuncle sore tumefacting virus, scald.
Radix Glycyrrhizae: nature and flavor: sweet, flat.Gui Jing: return spleen, stomach, lung meridian.Effect: QI invigorating invigorating middle warmer, relieving spasm to stop pain, eliminating fire and detoxication.Cure mainly: for the disease of laryngopharynx swelling and pain.
Refreshing and detoxicating provided by the invention drinks not only compatibility science, and preparation is simple, products obtained therefrom taking convenience, is easy to carry.In addition, excellent results of the present invention also shows:
1
,this refreshing and detoxicating drink is with refreshing and detoxicating, and removing damp and stopping pain is Main Function;
2
,this prescription meets the feature of Chinese medicine principle and septicemia initial stage patient body completely;
3, this refreshing and detoxicating drink long action time, short treating period, instant effect, safe without toxic side effect.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and test example, but protection domain is not limited thereto.
embodiment 1the refreshing and detoxicating drink at treatment septicemia initial stage, is prepared from by following bulk drugs: Radix Saposhnikoviae 3g, Herba Schizonepetae 4g, Radix Angelicae Dahuricae 6g, Fructus Garciniae oblongifoliae 3g, Rhizoma Et Radix Notopterygii 2g, Rhizoma Coptidis 4g, Fructus Forsythiae 6g, Radix Scutellariae 8g, Flos Lonicerae 20g, Herba Agerati Conyzoidis 4g, Radix Paeoniae Alba 6g Aralia continentalis.Kitagawa 2g, Poria cum Radix Pini 8g, Flos Sophorae Immaturus 3g, Radix Platycodonis 6g, Herba Catharanthi Rosei 4g, Radix Glycyrrhizae 4g.
The preparation method of the refreshing and detoxicating drink at above-mentioned treatment septicemia initial stage:
(1) Radix Saposhnikoviae to be placed in pot micro-stir-fry to buff, to take out and dry in the air cool to room temperature, make Radix Saposhnikoviae (parched);
(2) by Radix Saposhnikoviae (parched), Herba Schizonepetae, the Radix Angelicae Dahuricae, Rhizoma Coptidis, Fructus Forsythiae, Radix Scutellariae, Herba Agerati Conyzoidis, the Radix Paeoniae Alba, Aralia continentalis.Kitagawa, Poria cum Radix Pini, Herba Catharanthi Rosei, Radix Glycyrrhizae decontamination, clean and put into container, the distilled water adding medical material 6 times of weight floods 2 hours, then boil a turn little fire and decoct 20 minutes, filter and collect supernatant, leave recrement, recrement is watered big fire again and is fried open, turn after little fire is decocted and leach supernatant, after twice supernatant mix homogeneously, for subsequent use;
(3) get Fructus Garciniae oblongifoliae and Flos Sophorae Immaturus decontamination, microwave drying, pulverized 70 mesh sieves, and obtained traditional Chinese medicine fine powder, for subsequent use;
(4) Flos Lonicerae, Rhizoma Et Radix Notopterygii and Radix Platycodonis decontamination are cleaned, dry, add 80% ethanol of medical material weight 4 times, soak filtration in 16 hours, repeat soak once filter, merge twice filtrate, filtrate be concentrated into relative density 1.19(60 DEG C) thick paste, for subsequent use;
(5) by supernatant, fine powder and the thick paste mix homogeneously obtained by above-mentioned steps (2)-(4), sterilizing subpackage.
The instructions of taking of refreshing and detoxicating drink of the present invention: refreshing and detoxicating drink is 7 days courses for the treatment of, takes every day 2-3 time (warm), each 30-50ml.
embodiment 2the refreshing and detoxicating drink at treatment septicemia initial stage, is prepared from by following bulk drugs: Radix Saposhnikoviae 9g, Herba Schizonepetae 8g, Radix Angelicae Dahuricae 12g, Fructus Garciniae oblongifoliae 6g, Rhizoma Et Radix Notopterygii 6g, Rhizoma Coptidis 12g, Fructus Forsythiae 15g, Radix Scutellariae 16g, Flos Lonicerae 35g, Herba Agerati Conyzoidis 9g, Radix Paeoniae Alba 12g Aralia continentalis.Kitagawa 6g, Poria cum Radix Pini 15g, Flos Sophorae Immaturus 6g, Radix Platycodonis 15g, Herba Catharanthi Rosei 9g, Radix Glycyrrhizae 9g.
The preparation method of the refreshing and detoxicating drink at above-mentioned treatment septicemia initial stage:
(1) Radix Saposhnikoviae to be placed in pot micro-stir-fry to buff, to take out and dry in the air cool to room temperature, make Radix Saposhnikoviae (parched);
(2) by Radix Saposhnikoviae (parched), Herba Schizonepetae, the Radix Angelicae Dahuricae, Rhizoma Coptidis, Fructus Forsythiae, Radix Scutellariae, Herba Agerati Conyzoidis, the Radix Paeoniae Alba, Aralia continentalis.Kitagawa, Poria cum Radix Pini, Herba Catharanthi Rosei, Radix Glycyrrhizae decontamination, clean and put into container, the distilled water adding medical material 8 times of weight floods 4 hours, then boil a turn little fire and decoct 30 minutes, filter and collect supernatant, leave recrement, recrement is watered big fire again and is fried open, turn after little fire is decocted and leach supernatant, after twice supernatant mix homogeneously, for subsequent use;
(3) get Fructus Garciniae oblongifoliae and Flos Sophorae Immaturus decontamination, microwave drying, pulverized 110 mesh sieves, and obtained traditional Chinese medicine fine powder, for subsequent use;
(4) Flos Lonicerae, Rhizoma Et Radix Notopterygii and Radix Platycodonis decontamination are cleaned, dry, add 80% ethanol of medical material weight 8 times, soak filtration in 20 hours, repeat soak once filter, merge twice filtrate, filtrate be concentrated into relative density 1.19(60 DEG C) thick paste, for subsequent use;
(5) by supernatant, fine powder and the thick paste mix homogeneously obtained by above-mentioned steps (2)-(4), sterilizing subpackage.
The instructions of taking of refreshing and detoxicating drink of the present invention: refreshing and detoxicating drink is 7 days courses for the treatment of, takes every day 2-3 time (warm), each 30-50ml.
Model case: xxx, women, 23 years old.Be admitted to hospital because repeatedly generating heat more than 20 day.There is heating in patient, most high fever 40 DEG C before more than 20 day, companion's fear of cold, headache, nausea and vomiting.Without having sore throat, without arthralgia, without diseases such as erythra.Patient buys the medicines such as cephalo by oneself and takes rear nothing alleviation, and patient treats 3 days (concrete dosage is not quite clear) at a local private clinic quiet cefotaxime sodium, hydrocortisone then, drug withdrawal after body temperature is normal.After 2 days there is heating in patient again, and night, most high fever reached 40 DEG C.AD is the septicemia initial stage.
Take refreshing and detoxicating of the present invention drink, adopt every day 3 times (warm), each 30ml 7 days is a course for the treatment of.After taking 3 days, spirit takes a turn for the better, resolution of fever, and fear of cold, headache alleviate, and after taking 1 course for the treatment of, patient mental is in good condition, and Nausea and vomiting symptom alleviates, and takes 15 days, and every ill symptoms disappears completely, and recovery from illness, has no recurrence.
embodiment 3the refreshing and detoxicating drink at treatment septicemia initial stage, is prepared from by following bulk drugs: Radix Saposhnikoviae 4g, Herba Schizonepetae 5g, Radix Angelicae Dahuricae 8g, Fructus Garciniae oblongifoliae 4g, Rhizoma Et Radix Notopterygii 3g, Rhizoma Coptidis 6g, Fructus Forsythiae 9g, Radix Scutellariae 10g, Flos Lonicerae 25g, Herba Agerati Conyzoidis 5g, Radix Paeoniae Alba 8g Aralia continentalis.Kitagawa 3g, Poria cum Radix Pini 9g, Flos Sophorae Immaturus 4g, Radix Platycodonis 9g, Herba Catharanthi Rosei 5g, Radix Glycyrrhizae 5g.The preparation method of the refreshing and detoxicating drink at above-mentioned treatment septicemia initial stage:
The preparation method of the refreshing and detoxicating drink at above-mentioned treatment septicemia initial stage:
(1) Radix Saposhnikoviae to be placed in pot micro-stir-fry to buff, to take out and dry in the air cool to room temperature, make Radix Saposhnikoviae (parched);
(2) by Radix Saposhnikoviae (parched), Herba Schizonepetae, the Radix Angelicae Dahuricae, Rhizoma Coptidis, Fructus Forsythiae, Radix Scutellariae, Herba Agerati Conyzoidis, the Radix Paeoniae Alba, Aralia continentalis.Kitagawa, Poria cum Radix Pini, Herba Catharanthi Rosei, Radix Glycyrrhizae decontamination, clean and put into container, the distilled water adding medical material 6.5 times of weight floods 2.5 hours, then boil a turn little fire and decoct 20 minutes, filter and collect supernatant, leave recrement, recrement is watered big fire again and is fried open, turn after little fire is decocted and leach supernatant, after twice supernatant mix homogeneously, for subsequent use;
(3) get Fructus Garciniae oblongifoliae and Flos Sophorae Immaturus decontamination, microwave drying, pulverized 80 mesh sieves, and obtained traditional Chinese medicine fine powder, for subsequent use;
(4) Flos Lonicerae, Rhizoma Et Radix Notopterygii and Radix Platycodonis decontamination are cleaned, dry, add 80% ethanol of medical material weight 5 times, soak filtration in 17 hours, repeat soak once filter, merge twice filtrate, filtrate be concentrated into relative density 1.19(60 DEG C) thick paste, for subsequent use;
(5) by supernatant, fine powder and the thick paste mix homogeneously obtained by above-mentioned steps (2)-(4), sterilizing subpackage.
The instructions of taking of refreshing and detoxicating drink of the present invention: refreshing and detoxicating drink is 7 days courses for the treatment of, takes every day 2-3 time (warm), each 30-50ml.
embodiment 4the refreshing and detoxicating drink at treatment septicemia initial stage, is prepared from by following bulk drugs: Radix Saposhnikoviae 8g, Herba Schizonepetae 7g, Radix Angelicae Dahuricae 10g, Fructus Garciniae oblongifoliae 5g, Rhizoma Et Radix Notopterygii 5g, Rhizoma Coptidis 10g, Fructus Forsythiae 12g, Radix Scutellariae 14g, Flos Lonicerae 30g, Herba Agerati Conyzoidis 8g, Radix Paeoniae Alba 10g Aralia continentalis.Kitagawa 5g, Poria cum Radix Pini 14g, Flos Sophorae Immaturus 5g, Radix Platycodonis 12g, Herba Catharanthi Rosei 8g, Radix Glycyrrhizae 8g.
The preparation method of the refreshing and detoxicating drink at above-mentioned treatment septicemia initial stage:
(1) Radix Saposhnikoviae to be placed in pot micro-stir-fry to buff, to take out and dry in the air cool to room temperature, make Radix Saposhnikoviae (parched);
(2) by Radix Saposhnikoviae (parched), Herba Schizonepetae, the Radix Angelicae Dahuricae, Rhizoma Coptidis, Fructus Forsythiae, Radix Scutellariae, Herba Agerati Conyzoidis, the Radix Paeoniae Alba, Aralia continentalis.Kitagawa, Poria cum Radix Pini, Herba Catharanthi Rosei, Radix Glycyrrhizae decontamination, clean and put into container, the distilled water adding medical material 7.5 times of weight floods 3.5 hours, then boil a turn little fire and decoct 25 minutes, filter and collect supernatant, leave recrement, recrement is watered big fire again and is fried open, turn after little fire is decocted and leach supernatant, after twice supernatant mix homogeneously, for subsequent use;
(3) get Fructus Garciniae oblongifoliae and Flos Sophorae Immaturus decontamination, microwave drying, pulverized 100 mesh sieves, and obtained traditional Chinese medicine fine powder, for subsequent use;
(4) Flos Lonicerae, Rhizoma Et Radix Notopterygii and Radix Platycodonis decontamination are cleaned, dry, add 80% ethanol of medical material weight 7 times, soak filtration in 19 hours, repeat soak once filter, merge twice filtrate, filtrate be concentrated into relative density 1.19(60 DEG C) thick paste, for subsequent use;
(5) by supernatant, fine powder and the thick paste mix homogeneously obtained by above-mentioned steps (2)-(4), sterilizing subpackage.
The instructions of taking of refreshing and detoxicating drink of the present invention: refreshing and detoxicating drink is 7 days courses for the treatment of, takes every day 3 times (warm), each 30-50ml.
Model case: xxx, male, 34 years old.There is heating without obvious inducement in patient, body temperature fluctuation is in 39 DEG C ~ 40 DEG C, and with headache, Nausea and vomiting, blood routine examination total white blood cells reduces, 21 × 109/L; Waist is worn CSF and is checked: sugar, albumen slightly raise, and chloride is lower slightly, and respiratory rhythm is obviously accelerated, and two pulmonary respiration sound is thick.Clinical diagnosis is the septicemia initial stage.
Take refreshing and detoxicating of the present invention drink, adopt every day 3 times (warm), each 50ml 7 days is a course for the treatment of.After taking 5 days, patient mental's state takes a turn for the better, high pyretolysis, and headache syndromes alleviates, and continues to take to two courses for the treatment of, and patient's malaise symptoms disappears, and breathes normal, and blood training is negative.Rear use refreshing and detoxicating drink of the present invention consolidate curative effect 6 days, patient fully recovers, and has no recurrence.
embodiment 5the refreshing and detoxicating drink at treatment septicemia initial stage, is prepared from by following bulk drugs: Radix Saposhnikoviae 6g, Herba Schizonepetae 6g, Radix Angelicae Dahuricae 9g, Fructus Garciniae oblongifoliae 4.5g, Rhizoma Et Radix Notopterygii 4g, Rhizoma Coptidis 8g, Fructus Forsythiae 10.5g, Radix Scutellariae 12g, Flos Lonicerae 22.5g, Herba Agerati Conyzoidis 6.5g, Radix Paeoniae Alba 9g Aralia continentalis.Kitagawa 4g, Poria cum Radix Pini 11.5g, Flos Sophorae Immaturus 4.5g, Radix Platycodonis 10.5g, Herba Catharanthi Rosei 6.5g, Radix Glycyrrhizae 6.5g.
The preparation method of the refreshing and detoxicating drink at above-mentioned treatment septicemia initial stage:
(Radix Saposhnikoviae to be placed in pot micro-stir-fry to buff by (1), takes out to dry in the air cool to room temperature, makes Radix Saposhnikoviae (parched);
(2) by Radix Saposhnikoviae (parched), Herba Schizonepetae, the Radix Angelicae Dahuricae, Rhizoma Coptidis, Fructus Forsythiae, Radix Scutellariae, Herba Agerati Conyzoidis, the Radix Paeoniae Alba, Aralia continentalis.Kitagawa, Poria cum Radix Pini, Herba Catharanthi Rosei, Radix Glycyrrhizae decontamination, clean and put into container, the distilled water adding medical material 7 times of weight floods 3 hours, then boil a turn little fire and decoct 25 minutes, filter and collect supernatant, leave recrement, recrement is watered big fire again and is fried open, turn after little fire is decocted and leach supernatant, after twice supernatant mix homogeneously, for subsequent use;
(3) get Fructus Garciniae oblongifoliae and Flos Sophorae Immaturus decontamination, microwave drying, pulverized 90 mesh sieves, and obtained traditional Chinese medicine fine powder, for subsequent use;
(4) Flos Lonicerae, Rhizoma Et Radix Notopterygii and Radix Platycodonis decontamination are cleaned, dry, add 80% ethanol of medical material weight 6 times, soak filtration in 18 hours, repeat soak once filter, merge twice filtrate, filtrate be concentrated into relative density 1.19(60 DEG C) thick paste, for subsequent use;
(5) by supernatant, fine powder and the thick paste mix homogeneously obtained by above-mentioned steps (2)-(4), sterilizing subpackage.
The instructions of taking of refreshing and detoxicating drink of the present invention: refreshing and detoxicating drink is 7 days courses for the treatment of, takes every day 3 times (warm), each 30-50ml.
test example 1the clinical practice of the refreshing and detoxicating drink at embodiment 5 gained treatment septicemia initial stage: in March, 2011, in December ,-2012 screened 237 routine septicemia initial stage patients in 5 hospitals, wherein women 125 example, male 112 example, oldest is 75 years old, minimal ages is 1 years old, and the mean age is 42.3 years old.Before test 1 week, carry out Continuous Observation to this crowd, record symptom and change, be divided into two groups at random, experimental group and matched group, experimental group takes embodiment 5 products obtained therefrom, and matched group uses conventional dose (such as penicillin, gentamycin, rifampicin).Using method is: take every day 3 times (warm), each 30-50ml(adjusts to some extent depending on concrete condition), within 7 days, be a course for the treatment of.Curative effect situation criterion: cure: take two courses for the treatment of of this product, heating paresthesia disappears repeatedly, and the malaise symptoms such as fear of cold, shiver with cold, headache obviously improve, and energy obviously strengthens; Effective: take two courses for the treatment of of this product, heating paresthesia goes down repeatedly, and the malaise symptoms such as fear of cold, arthralgia alleviates or partial disappearance, energy strengthens; Invalid: take two courses for the treatment of of this product, malaise symptoms is unchanged.Result is as shown in table 1.
Table 1: take embodiment 5 product 1-75 year septicemia initial stage patient treatment outcome
Therapeutic effect: cure 134 examples (71.7%), effective 43 examples (23%), invalid 10 examples (5.3%), total effective rate 94.7%.Successful is better than matched group.
Take period symptom and change of spirit as shown in table 2.
Table 2:
The present invention selects Radix Saposhnikoviae, Herba Schizonepetae, the Radix Angelicae Dahuricae, Fructus Garciniae oblongifoliae etc. to carry out compatibility, produces synergism, can more effectively treat the septicemia initial stage after making these drug regimens.In side, Flos Lonicerae is used for heat-clearing and toxic substances removing, dispelling wind and heat pathogens; Poria cum Radix Pini, Radix Saposhnikoviae, Herba Schizonepetae master are at removing dampness to relieve pain; Rhizoma Coptidis and Fructus Forsythiae are used for dispersing swelling and dissipating binds, cooling blood for hemostasis; Radix Scutellariae is used for heat clearing and damp drying, eliminating fire and detoxication; Radix Platycodonis is used for blood circulation promoting and blood stasis dispelling, loosening bowel to relieve constipation, relieving cough and asthma; The Radix Paeoniae Alba, Radix Glycyrrhizae are used for QI invigorating invigorating middle warmer, suppressing the hyperactive liver pain relieving.All medicines share, refreshing and detoxicating, removing damp and stopping pain, invigorating the spleen and replenishing QI, improve the immunocompetence of body, obtain good therapeutic effect.After experimental group patient takes 5 days, taking a turn for the better appears in the state of an illness of more than 47% people, resolution of fever; Continue to take 5 days, the malaise symptoms of more than 78% people day by day improves or disappears, and headache alleviates; When taking to 15 days, check the fever of discovery more than 92% people, the disappearance of headache malaise symptoms, some patients self-induction is fully recovered, and spiritual antisecosis is normal.Experimental group patient takes more than 15 days, and effective percentage can reach 92%, and matched group effective percentage is only 75%, and two groups of therapeutic effect exist significant difference.
It should be pointed out that detailed description of the invention is the more representational example of the present invention, obvious technical scheme of the present invention is not limited to above-described embodiment, can also have a lot of distortion.Those of ordinary skill in the art, with the present invention clear and definite disclosed or according to undoubted the obtaining of the written description of file, the claimed scope of this patent all should be thought.
Claims (1)
1. treat the refreshing and detoxicating drink at septicemia initial stage, it is characterized in that, get following bulk drugs: Radix Saposhnikoviae 6g, Herba Schizonepetae 6g, Radix Angelicae Dahuricae 9g, Fructus Garciniae oblongifoliae 4.5g, Rhizoma Et Radix Notopterygii 4g, Rhizoma Coptidis 8g, Fructus Forsythiae 10.5g, Radix Scutellariae 12g, Flos Lonicerae 22.5g, Herba Agerati Conyzoidis 6.5g, Radix Paeoniae Alba 9g Aralia continentalis.Kitagawa 4g, Poria cum Radix Pini 11.5g, Flos Sophorae Immaturus 4.5g, Radix Platycodonis 10.5g, Herba Catharanthi Rosei 6.5g, Radix Glycyrrhizae 6.5g; Preparation method:
(1) Radix Saposhnikoviae to be placed in pot micro-stir-fry to buff, to take out and dry in the air cool to room temperature, make Radix Saposhnikoviae (parched);
(2) by Radix Saposhnikoviae (parched), Herba Schizonepetae, the Radix Angelicae Dahuricae, Rhizoma Coptidis, Fructus Forsythiae, Radix Scutellariae, Herba Agerati Conyzoidis, the Radix Paeoniae Alba, Aralia continentalis.Kitagawa, Poria cum Radix Pini, Herba Catharanthi Rosei, Radix Glycyrrhizae decontamination, clean and put into container, the distilled water adding medical material 7 times of weight floods 3 hours, then boil a turn little fire and decoct 25 minutes, filter and collect supernatant, leave recrement, recrement is watered big fire again and is fried open, turn after little fire is decocted and leach supernatant, after twice supernatant mix homogeneously, for subsequent use;
(3) get Fructus Garciniae oblongifoliae and Flos Sophorae Immaturus decontamination, microwave drying, pulverized 90 mesh sieves, and obtained traditional Chinese medicine fine powder, for subsequent use;
(4) Flos Lonicerae, Rhizoma Et Radix Notopterygii and Radix Platycodonis decontamination are cleaned, dry, add 80% ethanol of medical material weight 6 times, soak filtration in 18 hours, repeat to soak and once filter, merge twice filtrate, filtrate is concentrated into the thick paste of relative density 1.19, for subsequent use;
(5) by supernatant, fine powder and the thick paste mix homogeneously obtained by above-mentioned steps (2)-(4), sterilizing subpackage.
Priority Applications (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410420077.4A CN104147166B (en) | 2014-08-25 | 2014-08-25 | Septicemia initial stage refreshing and detoxicating drink and method for making |
| CN201510564299.8A CN105106340A (en) | 2014-08-25 | 2014-08-25 | Coolness clearing and toxin resolving drink for treating initial septicemia |
| CN201510564703.1A CN105168419A (en) | 2014-08-25 | 2014-08-25 | Cooling and detoxification beverage for treating early-stage septicemia |
| CN201510564328.0A CN105106341A (en) | 2014-08-25 | 2014-08-25 | Preparation process of coolness clearing and toxin resolving drink for treating initial septicemia |
| CN201510564329.5A CN105147794A (en) | 2014-08-25 | 2014-08-25 | Cooling and disintoxicating decoction for treating early sepsis and preparation method of cooling and disintoxicating decoction |
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| CN201410420077.4A CN104147166B (en) | 2014-08-25 | 2014-08-25 | Septicemia initial stage refreshing and detoxicating drink and method for making |
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| CN201510564703.1A Division CN105168419A (en) | 2014-08-25 | 2014-08-25 | Cooling and detoxification beverage for treating early-stage septicemia |
| CN201510564328.0A Division CN105106341A (en) | 2014-08-25 | 2014-08-25 | Preparation process of coolness clearing and toxin resolving drink for treating initial septicemia |
| CN201510564299.8A Division CN105106340A (en) | 2014-08-25 | 2014-08-25 | Coolness clearing and toxin resolving drink for treating initial septicemia |
| CN201510564329.5A Division CN105147794A (en) | 2014-08-25 | 2014-08-25 | Cooling and disintoxicating decoction for treating early sepsis and preparation method of cooling and disintoxicating decoction |
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| CN201410420077.4A Expired - Fee Related CN104147166B (en) | 2014-08-25 | 2014-08-25 | Septicemia initial stage refreshing and detoxicating drink and method for making |
| CN201510564328.0A Pending CN105106341A (en) | 2014-08-25 | 2014-08-25 | Preparation process of coolness clearing and toxin resolving drink for treating initial septicemia |
| CN201510564703.1A Pending CN105168419A (en) | 2014-08-25 | 2014-08-25 | Cooling and detoxification beverage for treating early-stage septicemia |
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| CN201510564299.8A Pending CN105106340A (en) | 2014-08-25 | 2014-08-25 | Coolness clearing and toxin resolving drink for treating initial septicemia |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1176798A (en) * | 1996-09-13 | 1998-03-25 | 曾青兰 | Medicine for treating cancer or hematosepsis and method for preparing same |
| CN101698078A (en) * | 2009-11-11 | 2010-04-28 | 秦跃山 | Traditional Chinese medicine for treating septicemia |
| CN102357185A (en) * | 2011-10-27 | 2012-02-22 | 刘书霞 | Traditional Chinese medicine for treating septicemia |
| CN103041025A (en) * | 2012-12-23 | 2013-04-17 | 徐化利 | Traditional Chinese medicine formula for treating septicemia |
-
2014
- 2014-08-25 CN CN201510564329.5A patent/CN105147794A/en active Pending
- 2014-08-25 CN CN201410420077.4A patent/CN104147166B/en not_active Expired - Fee Related
- 2014-08-25 CN CN201510564328.0A patent/CN105106341A/en active Pending
- 2014-08-25 CN CN201510564703.1A patent/CN105168419A/en active Pending
- 2014-08-25 CN CN201510564299.8A patent/CN105106340A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1176798A (en) * | 1996-09-13 | 1998-03-25 | 曾青兰 | Medicine for treating cancer or hematosepsis and method for preparing same |
| CN101698078A (en) * | 2009-11-11 | 2010-04-28 | 秦跃山 | Traditional Chinese medicine for treating septicemia |
| CN102357185A (en) * | 2011-10-27 | 2012-02-22 | 刘书霞 | Traditional Chinese medicine for treating septicemia |
| CN103041025A (en) * | 2012-12-23 | 2013-04-17 | 徐化利 | Traditional Chinese medicine formula for treating septicemia |
Non-Patent Citations (1)
| Title |
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| 十味败毒汤治疗变应性亚败血症_SA;吴元重;《蚌埠医药》;19861001;第76页 * |
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| CN105106341A (en) | 2015-12-02 |
| CN105147794A (en) | 2015-12-16 |
| CN105168419A (en) | 2015-12-23 |
| CN104147166A (en) | 2014-11-19 |
| CN105106340A (en) | 2015-12-02 |
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