CN115708854A - A Chinese medicinal composition for treating dermatoses, and preparation method thereof - Google Patents
A Chinese medicinal composition for treating dermatoses, and preparation method thereof Download PDFInfo
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
The invention discloses a Chinese medicinal composition of a Sansang Xiaofeng mixture for treating skin diseases and a preparation method of the mixture, and belongs to the technical field of medicines, wherein the Chinese medicinal composition is prepared from the following raw materials: 15 parts of cassia twig, 30 parts of white paeony root, 20 parts of Chinese date, 10 parts of honey-fried licorice root, 30 parts of coix seed, 10 parts of bitter apricot seed, 15 parts of cynanchum atratum, 15 parts of mulberry leaf, 15 parts of dark plum, 30 parts of oyster (decocted first), 30 parts of Chinese yam, 15 parts of red halloysite (decocted first), 15 parts of white mulberry root-bark, 15 parts of liquorice, 20 parts of fragrant solomonseal rhizome and 20 parts of mulberry fruit; compared with the traditional preparation method, the traditional Chinese medicine composition has the advantages that the preparation method is different, the preparation method is complex, the concentrated traditional Chinese medicine composition has the same efficacy as a decoction, but the dosage of the traditional Chinese medicine composition to be taken by a patient is less, the emotion resistance of the patient to the traditional Chinese medicine can be relieved, the traditional Chinese medicine composition is easy to store and carry, and can be taken for a long time.
Description
Technical Field
The invention belongs to the technical field of medicines, and particularly relates to a traditional Chinese medicine composition of a three-mulberry wind-dispelling mixture for treating skin diseases and a preparation method of the mixture.
Background
Skin disorders are a general term for disorders occurring in the skin and skin appendages. The skin is the largest organ of the human body, the skin diseases are not only various, but also diseases occurring in various internal organs can be shown on the skin. The skin diseases caused by various reasons, such as skin diseases caused by infection factors, such as leprosy, scabies, mycosis, skin bacterial infection and the like, are often infected to a certain extent, which not only affects the physical health, but also causes panic and social discrimination.
The most used external drugs for treating skin diseases are different formulations of the same drug, such as solution, paste, powder, cream, lotion, ointment, tincture, emulsion and the like, and different formulations have different functions and indications, so the external drugs with different formulations are correctly selected according to clinical symptoms and skin lesion characteristics in different disease stages.
According to the publication: CN104147147A a Chinese medicinal composition for treating skin diseases and a preparation method thereof, the Chinese medicinal composition comprises the following raw materials in parts by weight: 80-120 parts of polygonum multiflorum, 40-60 parts of fructus psoraleae, 5-10 parts of syngnathus and 15-20 parts of hippocampus, has the effects of nourishing yin, tonifying kidney, dispelling wind, activating blood and the like, is mainly used for treating leucoderma, but has more dosage to be taken in the using process and is easy to form dependence with western medicines to generate side effect; CN115054662A a Chinese medicinal composition for the treatment of dermatosis and its preparation method, it is made from Chinese medicine of the following part by weight: the monarch drug is composed of the following drugs: 10-30 parts of radix rehmanniae and 5-25 parts of gardenia; the ministerial drug is composed of 5-20 parts of figwort and 5-15 parts of lophatherum gracile; the adjuvant drug comprises the following drugs: 5-20 parts of uncaria, 10-30 parts of cogongrass rhizome and 5-15 parts of hawthorn, and can effectively treat atopic dermatitis, eczema and the like.
The traditional Chinese medicine has a long history in China, and a plurality of medicinal materials have the effects of eliminating dampness, relieving swelling, promoting blood circulation, relieving pain, tonifying liver and kidney, strengthening muscles and bones and the like, so the invention provides the traditional Chinese medicine composition of the three-mulberry wind-dispelling mixture and the preparation method of the mixture, and can effectively treat skin diseases.
Disclosure of Invention
The invention aims to provide a traditional Chinese medicine composition of a Sansang Xiaofeng mixture for treating skin diseases and a preparation method of the mixture, and aims to solve the problems that the preparation purity of the medicine for treating skin diseases is low, and the quality is poor due to more added mixtures in the preparation process of the medicine for treating skin diseases in the background technology, so that the treatment effect is poor.
In order to achieve the purpose, the invention provides the following technical scheme: a traditional Chinese medicine composition of a Sansang Xiaofeng mixture for treating skin diseases is prepared from the following raw materials:
12-15 parts of cassia twig, 25-30 parts of white paeony root, 15-20 parts of Chinese date, 8-10 parts of honey-fried licorice root, 25-30 parts of coix seed, 8-10 parts of bitter apricot seed, 12-15 parts of cynanchum atratum, 12-15 parts of mulberry leaf, 12-15 parts of dark plum, 25-30 parts of oyster (decocted first), 25-30 parts of Chinese yam, 12-15 parts of red halloysite (decocted first), 12-15 parts of white mulberry root-bark, 15-20 parts of fragrant solomonseal rhizome, 15-20 parts of liquorice and 15-20 parts of mulberry fruit.
Preferably, the traditional Chinese medicine composition consists of the following raw materials: 15 parts of cassia twig, 30 parts of white paeony root, 20 parts of Chinese date, 10 parts of honey-fried licorice root, 30 parts of coix seed, 10 parts of bitter apricot seed, 15 parts of cynanchum atratum, 15 parts of mulberry leaf, 15 parts of dark plum fruit, 30 parts of oyster (decocted first), 30 parts of Chinese yam, 15 parts of red halloysite (decocted first), 15 parts of white mulberry root-bark, 15 parts of liquorice, 20 parts of fragrant solomonseal rhizome and 20 parts of mulberry fruit.
Preferably, the preparation method comprises the following steps: mashing the semen Armeniacae amarum.
Preferably, decocting, placing the above Concha Ostreae and Halloysitum rubrum into an extractor, adding 10 times of purified water, soaking for 30min, and extracting for 40 min.
Preferably, the first decoction is carried out, the mulberry leaves, the white mulberry root-bark, the mulberry fruits, the cassia twig, the Chinese dates, the coix seeds, the Chinese yams, the polygonatum odoratum, the white paeony roots, the liquorice roots, the bitter almonds (smashed), the cynanchum atratum, the dark plums and the honey-fried licorice roots are placed into an extractor, the first decocted liquid medicine and the dregs of the decoction are added, purified water with the weight 10 times of the total weight of the medicinal materials is added, the mixture is soaked for 30min and extracted for 1 hour, the liquid medicine is filtered by a 200-mesh standard sieve, the dregs of the decoction are left for later use, and volatile oil water is extracted for later use so as to be capable of carrying out good extraction on the medicinal materials.
Preferably, the second decocting is carried out, wherein the above residue is added with 8 times of purified water, extracted for 0.5h, filtered through a 200 mesh standard sieve for later use, and the residue is removed to extract volatile oil and water for later use.
Preferably, the liquid medicines decocted in two times are combined, the mixture is kept stand at room temperature for 24 hours, the supernate is taken, the mixture is subjected to vacuum concentration at 60 +/-5 ℃ under reduced pressure until the relative density is 1.08g/ml, a tubular centrifuge is used for centrifugation (the centrifugation parameter is 15000 r/min), and the liquid medicine is reserved after centrifugation.
Preferably, the concentrated liquid medicine is taken and heated to boiling, white sugar and ethylparaben are added, volatile oil and water are added after the temperature is reduced to room temperature, the mixture is uniformly mixed, the liquid medicine is filtered by a standard sieve of 200 meshes, and the finished product is obtained by subpackaging.
Preferably, the traditional Chinese medicine composition for treating the skin disease is a mixture.
Compared with the prior art, the invention has the beneficial effects that:
1. the traditional Chinese medicine composition of the three-mulberry wind-dispelling mixture for treating skin diseases and the preparation method of the mixture are characterized in that according to the theory of traditional Chinese medicine, the three-mulberry wind-dispelling mixture is prepared according to the monarch, minister, assistant and guide principles, mulberry leaves, mulberry bark and mulberry fruits are used as monarch, wind heat can be dispelled, lung heat can be cleared away, eyesight can be improved, cassia twig, chinese date, coix seeds, oysters, chinese yams, polygonatum odoratum and white paeony roots are used as ministers, the traditional Chinese medicine composition has the functions of warming and dredging channels and collaterals, treating external infection, wind cold, shoulder, arm and limb soreness and pain, liquorice, bitter apricot seeds, cynanchum atratum, dark plums and red halloysters are used as assistants, the traditional Chinese medicine composition has the effects of tonifying spleen and supplementing qi, moistening lung and arresting cough, clearing heat and removing toxin, harmonizing medicines and the like, and the honey-fried licorice root is used as a guide, has the effects of nourishing yin and moistening dryness, softening liver and calming wind, and is mainly used: the skin diseases (skin itch and rubella) caused by yin and blood deficiency and wind syndrome are extracted by multiple times of decoction and filtration, so that the effective medicinal components in the Chinese medicinal mixture have higher content, and the Chinese medicinal mixture has better curative effect on treating the skin diseases.
2. The traditional Chinese medicine composition of the three-mulberry wind-eliminating mixture for treating the skin diseases and the preparation method of the mixture thereof can treat both symptoms and root causes, and the formula can disperse and descend lung qi, dispel stagnated heat in the lung, regulate the ascending and descending of lung, spleen and kidney qi machines, purge heat, eliminate dampness and reduce phlegm and keep the five internal organs in a balanced state on the basis of dispelling exogenous evil; the disease is easy to relapse due to the fact that the disease is not prevented in advance, and the patient is easy to relapse due to the fact that the patient is subjected to external evil by taking the medicine, can effectively prevent invasion of the external evil, disperse and reduce lung qi, improve lung function, eliminate dampness and phlegm, prevent phlegm-dampness obstructing the lung to relapse and change to critical conditions, and play the role of preventing the disease and preventing the disease from changing due to the fact that the disease is prevented in advance; from the perspective of western medicine, the formula can improve symptoms, shorten treatment course, reduce recurrence rate of skin itch, avoid toxic and side effects caused by overuse of western medicine, avoid excessive dependence on western medicine, and avoid drug resistance caused by overuse of antibiotics; the medicine is convenient for the patient to store and carry, has simple taking method, good taste and obvious curative effect, and is easy to be accepted by the patient.
Drawings
FIG. 1 is a schematic view of the overall flow structure of the present invention.
Detailed Description
The present invention will be further described with reference to the following examples.
The following examples are intended to illustrate the invention but are not intended to limit the scope of the invention. The conditions in the embodiments may be further adjusted according to specific conditions, and simple modifications of the method of the present invention based on the concept of the present invention are all within the scope of the present invention as claimed.
The invention provides a Chinese medicinal composition of a Sansang Xiaofeng mixture for treating skin diseases and a preparation method of the mixture, wherein the Chinese medicinal composition is prepared from the following raw materials:
12-15 parts of cassia twig, 25-30 parts of white paeony root, 15-20 parts of Chinese date, 8-10 parts of honey-fried licorice root, 25-30 parts of coix seed, 8-10 parts of bitter apricot seed, 12-15 parts of cynanchum atratum, 12-15 parts of mulberry leaf, 12-15 parts of dark plum, 25-30 parts of oyster (decocted first), 25-30 parts of Chinese yam, 12-15 parts of red halloysite (decocted first), 12-15 parts of white mulberry root-bark, 15-20 parts of fragrant solomonseal rhizome, 15-20 parts of liquorice and 15-20 parts of mulberry fruit.
In the traditional Chinese medicine composition provided by the invention, the inventor researches the reasonable proportion and the synergistic effect of the components of the medicinal materials, so that the traditional Chinese medicine mixture prepared by the traditional Chinese medicine composition provided by the invention has good curative effect on treating skin diseases.
Specifically, in the traditional Chinese medicine composition provided by the invention, the action mechanism of each medicinal material component is as follows:
cassia twig: pungent and warm taste, nourishing spirit, harmonizing color, benefiting articulation, invigorating middle warmer and replenishing qi; has effects in inducing sweat, expelling pathogenic factors from muscles, warming and dredging channels and collaterals, and can be used for treating common cold, wind cold, and soreness of shoulder, arm and limb joints.
White peony root: sweet, pungent and warm; has effects in nourishing blood, regulating menstruation, softening liver, relieving pain, astringing yin, arresting sweating, and suppressing liver yang, and can be used for treating rheumatalgia, rubella pruritus, epilepsy, lyssodexis, and venomous snake bite.
Chinese date: sweet taste and warm nature; has effects of invigorating spleen and stomach, invigorating qi and blood, tranquilizing mind, regulating ying and wei, and regulating property of drugs, and can be used for treating spleen and stomach weakness, qi and blood deficiency, anorexia, loose stool, listlessness, asthenia, palpitation, insomnia, female hysteria, incoordination between ying and wei, etc.
Honey-fried licorice root: sweet and mild in nature, ascending and descending, floating and sinking; has effects of nourishing yin and blood, invigorating qi and activating yang, and recovering pulse and stopping palpitation, and can be used for treating heart yin and yang deficiency, consumptive disease, consumptive lung disease, lung dryness and yin injury.
Coix seed: sweet, light and cool in nature; it has effects in invigorating spleen, stomach and lung channels, promoting diuresis, invigorating spleen, relieving diarrhea, eliminating arthralgia, expelling pus, removing toxic substance, and resolving hard mass, and can be used for treating edema, loempe, dysuresia, spleen deficiency, diarrhea, damp arthralgia, spasm, pulmonary abscess, intestinal abscess, wart, and cancer.
Bitter apricot seeds: bitter and warm in nature to ventilate the lung; has the effect of loosening bowel to relieve constipation, and can be used for treating wind pathogen and intestinal dryness.
Radix cynanchi atrati: bitter, salty and cold; it has effects in clearing away heat and toxic materials, cooling blood, promoting urination, treating stranguria, removing vexation, relieving swelling, promoting granulation, and relieving pain, and can be used for treating fever due to pathogenic heat, yin deficiency, hectic fever, puerperal blood deficiency, heat stranguria, blood stranguria, superficial infection, pyogenic infection, and knife wound.
Mulberry leaf: cold in nature, sweet and bitter in taste; has effects in dispelling pathogenic wind and heat, clearing lung-heat, moistening dryness, removing liver fire, and improving eyesight, and can be used for treating wind-heat type common cold, lung heat type cough, dizziness, headache, and conjunctival congestion.
Dark plum: sour, astringent and neutral in flavor; it is effective in astringing lung, astringing intestine, promoting fluid production, and calming ascaris, and can be used for treating lung deficiency, chronic cough, chronic diarrhea, chronic dysentery, asthenia heat, diabetes, ascariasis, emesis, and abdominal pain.
Oyster shell: the taste is salty and mild; has effects in astringing yin, suppressing yang hyperactivity, arresting sweating, eliminating phlegm, and softening hard masses, and can be used for treating epilepsy, vertigo, spontaneous perspiration, night sweat, spermatorrhea, stranguria with turbid discharge, metrorrhagia, leukorrhagia, and goiter.
Chinese yam: sweet, warm, mild and nontoxic; has effects in tonifying deficiency, eliminating cold and heat, invigorating middle warmer, invigorating qi, strengthening muscle, and nourishing yin, and can be used for treating lumbago, asthenia, marasmus, five viscera, and dysphoria.
Halloysitum rubrum: sweet, sour, astringent and warm in nature; it enters large intestine and stomach meridians, has effects of astringing intestine, stopping bleeding, promoting granulation and healing sore, and can be used for treating chronic diarrhea, dysentery, stool hemorrhage, metrorrhagia, leukorrhagia, and pyocutaneous disease.
White mulberry root-bark: pungent, sweet and cold in flavor; it belongs to lung channel or lung and spleen channel, and has effects of purging lung, relieving asthma, inducing diuresis, relieving swelling, tonifying deficiency, promoting blood circulation, removing blood stasis, eliminating phlegm, relieving cough, stopping bleeding, promoting fluid production, relieving thirst, relaxing bowels with purgation, expelling intestinal parasites, resolving food stagnation, dispelling pathogenic wind, freeing strangury, and relieving pain, and can be used for treating diseases such as edema, diabetes, tracheitis, pleuritis, pertussis and epistaxis.
Fragrant solomonseal rhizome: mild in nature and sweet in taste; has effects in nourishing yin, moistening dryness, promoting fluid production, and quenching thirst, and can be used for treating yin injury of lung and stomach, cough due to dryness-heat, dry throat, thirst, and diabetes due to internal heat.
Licorice root: sweet and mild in taste; has effects of invigorating spleen and replenishing qi, moistening lung for arresting cough, clearing heat and detoxicating, and harmonizing the effects of the above medicines, and can be used for treating sore throat, spleen and stomach deficiency cold, peptic ulcer, poisoning, etc.
And (3) mulberry fruit: sweet in taste and slightly cold in nature; has effects of nourishing yin, replenishing blood, tranquilizing mind, improving immunity, improving sleep, delaying aging, reducing blood sugar and blood lipid, and preventing atherosclerosis.
As a preferred embodiment of the present invention, the content of each component of the traditional Chinese medicine composition is as follows: 15 parts of cassia twig, 30 parts of white paeony root, 20 parts of Chinese date, 10 parts of honey-fried licorice root, 30 parts of coix seed, 10 parts of bitter apricot seed, 15 parts of cynanchum atratum, 15 parts of mulberry leaf, 15 parts of dark plum fruit, 30 parts of oyster (decocted first), 30 parts of Chinese yam, 15 parts of red halloysite (decocted first), 15 parts of white mulberry root-bark, 15 parts of liquorice, 20 parts of fragrant solomonseal rhizome and 20 parts of mulberry fruit.
The invention also provides a preparation method of the traditional Chinese medicine mixture, which comprises the following steps: mashing the bitter apricot kernels for later use, decocting the bitter apricot kernels, putting the oysters and the red halloysite into an extractor, adding 10 times of purified water, soaking for 30 minutes, and extracting for 40 minutes.
Further, decocting for the first time, putting the mulberry leaves, the white mulberry root-bark, the mulberry fruits, the cassia twig, the Chinese dates, the coix seeds, the Chinese yams, the polygonatum odoratum, the white paeony roots, the liquorice roots, the bitter almonds (smashed), the cynanchum atratum, the dark plums and the honey-fried licorice roots into an extractor, adding the decocted liquid medicine and the dregs, adding purified water which is 10 times of the total weight of the medicinal materials, soaking for 30min, extracting for 1 hour, filtering the liquid medicine by a 200-mesh standard sieve, and taking the dregs for later use to extract volatile oil water for later use.
Further decocting for the second time, adding 8 times of purified water into the above residue, extracting for 0.5 hr, filtering with 200 mesh standard sieve, removing residue, and extracting volatile oil and water.
Further, combining the liquid medicines decocted for two times, standing at room temperature for 24h, taking supernate, carrying out vacuum concentration at 60 +/-5 ℃ under reduced pressure until the relative density is 1.08g/ml, centrifuging by using a tubular centrifuge (the centrifugation parameter is 15000 r/min), and centrifuging the liquid medicine for later use.
Further, heating the concentrated medicinal liquid to boil, adding white sugar and ethylparaben, cooling to room temperature, adding volatile oil and water, mixing, filtering the medicinal liquid with a standard sieve of 200 meshes, and packaging to obtain the final product, wherein the Chinese medicinal composition is a mixture.
The invention combines the influence of geographical environment, makes adjustment according to the change of climate environment, and embodies the characteristics of holistic concept, local treatment and treatment based on syndrome differentiation; compared with the traditional preparation method, the traditional Chinese medicine composition has the advantages that various medicinal materials are different in preparation method and complex in preparation method, the concentrated traditional Chinese medicine composition has the same efficacy as a decoction, but the dosage of the concentrated traditional Chinese medicine composition is less, the emotion resistance of a patient to the traditional Chinese medicine can be relieved, the traditional Chinese medicine composition is easier to be recognized and accepted by the patient, and the traditional Chinese medicine composition is extremely easy to store and carry and can be taken for a long time; the invention has the functions of relieving symptoms, shortening the treatment course and reducing the recurrence rate of skin, and can be clinically popularized and used.
Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
Claims (8)
1. The traditional Chinese medicine composition of the three-mulberry wind-eliminating mixture for treating skin diseases is characterized by comprising the following raw materials:
12-15 parts of cassia twig, 25-30 parts of white paeony root, 15-20 parts of Chinese date, 8-10 parts of honey-fried licorice root, 25-30 parts of coix seed, 8-10 parts of bitter apricot seed, 12-15 parts of cynanchum atratum, 12-15 parts of mulberry leaf, 12-15 parts of dark plum, 25-30 parts of oyster (decocted first), 25-30 parts of Chinese yam, 12-15 parts of halloysite (decocted first), 12-15 parts of white mulberry root-bark, 15-20 parts of polygonatum odoratum, 15-20 parts of liquorice and 15-20 parts of mulberry fruit.
2. The traditional Chinese medicine composition of claim 1, wherein the traditional Chinese medicine composition is prepared from the following raw materials: 15 parts of cassia twig, 30 parts of white paeony root, 20 parts of Chinese date, 10 parts of honey-fried licorice root, 30 parts of coix seed, 10 parts of bitter apricot seed, 15 parts of cynanchum atratum, 15 parts of mulberry leaf, 15 parts of dark plum fruit, 30 parts of oyster (decocted first), 30 parts of Chinese yam, 15 parts of red halloysite (decocted first), 15 parts of white mulberry root-bark, 15 parts of liquorice, 20 parts of fragrant solomonseal rhizome and 20 parts of mulberry fruit.
3. A Chinese medicinal composition of Sansang Xiaofeng mixture for treating skin diseases and a preparation method of the mixture are characterized in that the preparation method comprises the following steps: mashing the bitter apricot seeds of claim 1 or 2 for use.
4. The method according to claim 3, wherein the oyster shell and red halloysite of claim 1 or 2 are decocted, and the mixture is placed in an extractor, and 10 times of purified water is added, and the mixture is soaked for 30 minutes and extracted for 40 minutes.
5. The preparation method according to claim 4, characterized in that the first decoction is carried out, the mulberry leaves, the white mulberry root-bark, the mulberry seeds, the cassia twig, the Chinese dates, the coix seeds, the Chinese yams, the fragrant solomonseal rhizome, the white paeony roots, the liquorice roots, the bitter almonds (pounded), the cynanchum atratum, the dark plums and the honey-fried licorice roots according to the claim 1 or 2 are taken and put into an extractor, the decocted liquid medicine and the dregs are added, purified water which is 10 times of the total weight of the medicinal materials is added, the soaking is carried out for 30min, the extraction is carried out for 1 hour, the liquid medicine is filtered by a standard sieve of 200 meshes, the dregs are left and are used for standby, and volatile oil water is extracted for standby.
6. The preparation method of claim 5, wherein the second decocting is carried out by adding 8 times of purified water into the residue, extracting for 0.5 hr, filtering with 200 mesh standard sieve, removing residue, and extracting volatile oil and water.
7. The preparation method according to claim 6, wherein the above two decocted liquid medicines are combined, left to stand at room temperature for 24h, the supernatant is taken, vacuum-concentrated at 60 ± 5 ℃ under reduced pressure to a relative density of 1.08g/ml, and centrifuged by a tubular centrifuge (centrifugation parameter 15000 r/min), and the liquid medicine is ready for use after centrifugation.
8. The preparation method of claim 7, wherein the concentrated medicinal liquid is heated to boiling, white sugar and ethylparaben are added, volatile oil and water are added after the temperature is reduced to room temperature, the mixture is uniformly mixed, the medicinal liquid is filtered by a standard sieve of 200 meshes, and the finished product is obtained after subpackage.
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Application publication date: 20230224 |