CN105362961A

CN105362961A - Traditional Chinese medicine pill used for treating premature ovary failure and preparation method

Info

Publication number: CN105362961A
Application number: CN201510962833.0A
Authority: CN
Inventors: 夏修菲
Original assignee: Individual
Current assignee: Individual
Priority date: 2015-12-18
Filing date: 2015-12-18
Publication date: 2016-03-02

Abstract

The invention discloses a traditional Chinese medicine pill used for treating premature ovary failure and a preparation method, and belongs to the field of traditional Chinese medicine. The traditional Chinese medicine pill is prepared from cornus pulp, dried radix rehmanniae, atractylodes macrocephala koidz, herminium monorchis, fructus lycii, asparagus beans, potentilla anserine L extraction, rosa rugosa, cynanchum mooreanum hemsl., donkey-hide gelatin, white peony roots, polygonum multiflorum, black sesame, polygonum cuspidatum, rhizoma cyperi, vervain, tuber fleeceflower stems, madder, lycopus lucidus, semen platycladi, Geum urbanum L., rhizoma curcumae, radix glycyrrhizae and motherwort fruit. The medicine properties of the selected medicinal materials adapt to and supplement one another, the traditional Chinese medicine pill is special for the disease for disease causes, the traditional Chinese medicine pill has the functions of nourishing livers and kidneys, nourishing yin, clearing heat, strengthening spleens and stomachs, replenishing qi, enriching blood, regulating flow of qi, resolving depression, activating blood to promote menstruation and conducting tranquilizing by nourishing hearts, and is good in absorption effect, remarkable in treatment effect and free of toxic and side effects and clinical adverse reactions, and the clinical verification shows that the cure rate of the traditional Chinese medicine pill for premature ovary failure is high.

Description

A kind of medicine pill and preparation method being used for the treatment of premature ovarian failure

Art

The present invention relates to the field of Chinese medicines, particularly relate to a kind of medicine pill and the preparation method that are used for the treatment of premature ovarian failure.

Background technology

Premature ovarian failure (POF) refers to the phenomenon of the i.e. amenorrhea before in 40 years old that ovarian function failure causes.Feature is that former or secondary amenorrhea raise with blood Gonadotropin Level and estrogen level reduction, and with a series of low estrogen symptoms in various degree as hectic fever hyperhidrosis, flush, hyposexuality etc.The average natural menopause age of women is 50 ~ 52 years old, and age of meuopause also exists the difference of race and Area distribution, but its absolute value is more or less the same.

The treatment of current estrogen and progestogen artificial cycle is the common method of clinical treatment premature ovarian failure, effectively can alleviate estrogen and reduce symptom before and after a series of menopause of bringing, but hormonotherapy has certain side effect, and cure the symptoms, not the disease.In recent years, a lot of clinical expert sums up the etiology and pathogenesis etc. of premature ovarian failure from the angle analysis of the traditional Chinese medical science, from the viewpoint Coryza Treated by Syndrome Differentiation premature ovarian failure of the kidney invigorating, is nursed one's health and treats, achieve good progress by entirety.

Pill of the present invention sums up configuration through Long-term clinical to form, and suit the remedy to the case for the cause of disease, total tune treats premature ovarian failure, on the basis of enriching yin and nourishing kidney, also will take into account the mediation of other organs function.Invigorating the spleen and benefiting QI while the kidney invigorating, for the kidney invigorating essence provides source, also has effect of tranquilizing by nourishing the heart simultaneously; Blood stored in the liver, deficiency of liver-blood is the weary source of the sea of blood then, and blood depletion is amenorrhea then, therefore treats premature ovarian failure and also needs nourishing blood to suppress the hyperactive liver; Coordination between the heart and kidney, coordinating water and fire, the balance of the negative and positive of kidney could be ensured, need first mind calming for the kidney invigorating person.Therefore, pill of the present invention is by invigorating the liver and kidney, and benefiting essence-blood, adjusts taste, tranquilizing mind, and QI and blood is filled, and such ovary can be nourished, and makes the ovary of senilism regenerate life, thus obtains good therapeutic effect.

Summary of the invention

The invention provides a kind of medicine pill and the preparation method that are used for the treatment of premature ovarian failure, there is effect of nourishing the liver nourishing kidney, nourishing YIN and clearing away heat, invigorating the spleen and regulating the stomach, vigorate qi and replenish the blood, resolving depression of regulating the flow of vital energy, promoting blood circulation to restore menstrual flow, tranquilizing by nourishing the heart, cure the disease and ask source treating both the principal and secondary aspects of a disease, to premature ovarian failure, there is good curative effect.

For achieving the above object, technical scheme of the present invention is implemented as follows:

Be used for the treatment of a medicine pill for premature ovarian failure, raw material composition and the parts by weight of making described effective ingredient are:

Raw material composition and the parts by weight of making described effective ingredient are:

Be used for the treatment of a preparation method for the medicine pill of premature ovarian failure, comprise following processing step:

(1) Fructus Corni, the Radix Rehmanniae, the Rhizoma Atractylodis Macrocephalae, Semen vignae sinensis, Radix potentillae anserinae, Flos Rosae Rugosae, Radix Tylophorae arenicolae, Semen Sesami Nigrum, Herba Verbenae, Caulis Polygoni Multiflori, Herba Lycopi, bodhi perfume, Fructus Leonuri, Radix Glycyrrhizae are cleaned, dry rear mix homogeneously, put into container, add the water of 6 ~ 8 times amount in a reservoir, heated and boiled 2 ~ 3 hours, gets immersion after cooling; The water of 4 ~ 6 times amount is added again, heated and boiled 1 ~ 2 hour, immersion after cooling in remaining medicinal residues; Merge twice gained immersion, heating, evaporation and concentration is the thick paste of relative density 1.15 ~ 1.25, for subsequent use;

(2) musk orchid, Fructus Lycii, the Radix Paeoniae Alba, Radix Polygoni Multiflori, Rhizoma Polygoni Cuspidati are put into container, add the shao-hsing rice wine of 3 ~ 5 times amount, cool after boiling, continue immersion 3 ~ 5 hours, get immersion; In remaining medicinal residues, add the shao-hsing rice wine of 2 ~ 4 times amount again, put after boiling and dry in the air, continue immersion 2 ~ 4 hours, get immersion; Merge twice gained immersion, add and steam the thick paste that evaporation and concentration is relative density 1.10 ~ 1.20, for subsequent use;

(3) dry clean for Rhizoma Cyperi, put into container after pulverizing, add the mature vinegar of 3 ~ 4 times amount in a reservoir, soak after 4 ~ 6 hours, get immersion; In remaining medicinal residues, add the mature vinegar of 2 ~ 3 times amount again, soak after 3 ~ 4 hours, get immersion; Merge twice gained immersion, add the water of 2 ~ 3 times amount, the thick paste of heating evaporation simmer down to relative density 1.30 ~ 1.40, for subsequent use;

(4) by Radix Rubiae clean dry after put into iron pan, the micro-stir-fry of slow fire, fry to epidermis turn yellow after, spray Ji Me Lao Jiu, continue fry sallow to epidermis after, taking-up cools, and pulverizing is ground into powder, cross 120 order dusting covers, obtain fine powder, for subsequent use;

(5) dry clean for Rhizoma Curcumae, add quantitative rice vinegar and mix thoroughly, after moistening to vinegar is sucked, put in parch container, heat fried dry with slow fire, taking-up cools, and sieve removes chip, and pulverizing is ground into powder, crosses 120 order dusting covers, obtains fine powder, for subsequent use;

(6) Semen Platycladi pulverizing is ground into powder, cross 120 order dusting covers, obtain fine powder, for subsequent use;

(7), after being pulverized by Colla Corii Asini and grinding into powder, add a small amount of boiled water and mix thoroughly, then water proof is heated to Colla Corii Asini and dissolves completely, obtains medicinal liquid, for subsequent use.

(8) by the thick paste of step (1), step (2), step (3) gained, mix with the fine powder of gained in step (4), step (5), step (6) and the medicinal liquid of the middle gained of step (7), add after refined honey stirs, be prepared as the pill of every 8g.

The property of medicine of the present invention's Chinese medicine used is as follows:

Fructus Corni: sour in the mouth; Slightly warm in nature, returns liver; Kidney channel.Liver and kidney tonifying; Convergence is solid de-, cures mainly: waist is had a dizzy spell; Deafness and tinnitus; Soreness of the waist and knees; Xian essence spermatorrhea; Frequent micturition; Incessant sweating due to debility; Woman uterine bleeding." Elementary Medicine ": this astringent of Fructus Corni also, how can lead to and send out heresy? covering all diseases is all bottom deficiency and coldness, the tonic Liver and kidney of use, and with Yi Qiyuan, then the five internal organs Amway, only, the meaning of the light dredging of Fei Ruota medicine also for the logical and sharp person of the person of closing.Modern medicine study shows: Fructus Corni has antibacterial, immunity moderation, blood sugar lowering, blood fat reducing, antioxidation, anticancer, the function such as anti-AIDS, heart tonifying.

The Radix Rehmanniae: sweet in the mouth; Bitter; Cold nature.GUIXIN; Liver; Kidney channel.Nourishing YIN and clearing away heat; Removing heat from blood is enriched blood.Cure mainly calentura excessive thirst; Interior-heat is quenched one's thirst; Hectic fever due to YIN-deficiency consumptive fever; Epidemic febrile disease sends out speckle; Haematemesis caused by heat in blood; Metrorrhagia; Hematuria; Have blood in stool; Blood deficiency and yellow complexion; Dizzy cardiopalmus; Insufficiency of blood amenorrhea." Japan hanako materia medica " carries: " control palpitation with fear labor bad, cardiopulmonary damage, and spit blood, epistaxis, married woman's metrorrhagia bruise, helps muscles and bones." modern medicine study confirms, the Radix Rehmanniae is effective immunostimulant, comprises multiclass aminoacid, the saccharide beneficial to human body, and have heart tonifying, diuresis, blood pressure lowering, blood sugar lowering, protect the liver, the pharmacological action such as antibacterial, hemocytes increasing.

The Rhizoma Atractylodis Macrocephalae: bitter in the mouth; Sweet; Warm in nature.Return spleen; Stomach warp.Invigorating the spleen and benefiting QI; Dampness diuretic; Hidroschesis; Antiabortive.Cure mainly deficiency-weakness of spleen-QI; Spiritlessness and weakness; Lack of appetite abdominal distention; Large loose stool is thin; Fluid-retention stagnating in the interior; Dysuria; Edema; Dizziness due to fluid-retention; Arthralgia chiefly caused by damp pathogen is ached; Spontaneous sweating due to deficiency of QI; Frequent fetal movement." herbal classic is met former " carries: " art, raw with there being dehumidifying benefit dry, expectorant diuretic, controls anemofrigid-damp arthralgia, dead flesh convulsion subcutaneous ulcer, blood between loose waist umbilicus, and chong channel is disease, the merit of inverse gas pain in the abdomen; Make ripe, have and middle QI invigorating, slake thirst and help produce saliva, hidroschesis heat extraction, enters diet, antiabortive effect." modern medicine study confirmation, the Rhizoma Atractylodis Macrocephalae has effect that is strong and raising body resistance against diseases, strengthen the phagocytic function of reticuloendothelial system, strengthen the function of leukocytes phagocytic staphylococcus aureus, leukogenic effect is had to leukopenia, improve lymhocyte transformation rate, promote cellular immune function, to staphylococcus aureus, Hemolytic streptococcus, viridans streptococci, streptococcus pneumoniae, meningococcus, diphtheria corynebacterium, bacillus subtilis has inhibitory action in various degree, to acrothesium floccosum, star-shaped nocardia, trichophyton, the dermatophytess such as Trichophyton concentricunm have certain inhibitory action.

Musk orchid: sweet in the mouth, warm in nature.Enriching yin and nourishing kidney, nourishing the stomach, regulating menstruation.For neurasthenia, dizzy insomnia, irritated thirsty inappetence, early whitening of beard and hair, menoxenia.

Fructus Lycii: sweet in the mouth; Property is put down.Return liver; Kidney; Lung meridian.Nourishing the liver; Nourishing kidney; Lung moistening.Cure mainly caused by liver and kidney deficiency; Have a dizzy spell; Visual one clear; Soreness of the waist and knees; The expensive essence of sexual impotence; Cough due to consumptive disease; To quench one's thirst taking fluids profusely." book on Chinese herbal medicine just " carries: " improve visual and auditory acuity, adds the solid marrow of essence, strengthen the muscle and bone, and kind benefit impairment caused by overstrain, especially only quenches one's thirst." modern medicine study confirm, Fructus Lycii scalable body's immunity, can effectively Tumor suppression grow and cell mutation, there is the effect of the aspect such as slow down aging, anti-fatty liver, adjusting blood lipid and blood glucose, promotion hemopoietic function.

Semen vignae sinensis: sweet in the mouth, property is put down.Return spleen, kidney channel.Strengthening spleen, tonifying kidney.Control weakness of the spleen and stomach, dysentery, tell inverse, quench one's thirst, seminal emission, leucorrhea, nebulousurine, frequent micturition." detailed outline ": " QI invigorating in reason, tonifying kidney and promoting digestion, and the five internal organs adjust battalion to defend, spermatogenesis marrow.Only quench one's thirst, tell inverse, let out dysentery, frequent micturition, separate the big poison of Mus."

Radix potentillae anserinae: sweet in the mouth; Bitter; Cold.Return spleen; Stomach warp.Fill blood, strengthening the spleen and stomach, promoting the production of body fluid to quench thirst, dampness removing.For anemia after being ill, malnutrition, insufficiency of the spleen diarrhoea, rheumatic arthralgia." Chinese herbal medicine is commonly used in Tibet ": " vigorate qi and replenish the blood, controls insufficiency of the spleen diarrhoea, after being ill anemia, malnutrition for invigorating spleen and reinforcing stomach, promoting the production of body fluid to quench thirst." modern study proves: Radix potentillae anserinae contains two kinds of compositions of contraction and relaxing smooth muscle, has certain influence, and have cardiotonic to smooth muscle.

Flos Rosae Rugosae: sweet in the mouth; Micro-hardship; Warm in nature; Nontoxic.Return liver; Spleen channel.To regulate the flow of vital energy resolving depression; Regulating menstruation by adjusting the flow of blood.Cure mainly chest and diaphragm caused by depression of liver-QI full vexed, gastral cavity side of body distending pain, breast is done swollen, menoxenia, and dysentery is had loose bowels, leukorrhagia, traumatic injury carbuncle." book on Chinese herbal medicine justice ": Flos Rosae Rugosae, fragrance is the denseest, turbid clearly and not, and and violent, easing the affected liver is waken up stomach, and gas is invigorated blood circulation, and a surname is logical stops up stagnant and absolutely not pungent temperature is just dry fraud, disconnectedly pushes away among edema caused by disorder of QI medicine, has prompt effect and the most tractable person most, and fragrant all product, there is no equal.

Radix Tylophorae arenicolae: acrid in the mouth, property is put down.The kidney invigorating, spleen invigorating, removing toxic substances.Control chronic consumptive disease chronic cough, edema, leucorrhea, menoxenia, scrofula, skin ulcer scabies." Shaanxi Chinese herbal medicine ": " enriching yin and nourishing kidney, invigorating the spleen and benefiting QI, regulating menstruation and activating blood.Control menoxenia, deficiency of YIN leucorrhea."

Colla Corii Asini: sweet in the mouth; Property is put down.Enter liver; Lung; Kidney channel.Enrich blood; Hemostasis; YIN nourishing; Moisturize.Cure mainly syndrome of deficiency of blood; Asthenia is spat blood; Spit blood; Hematuria; Have blood in stool; Dysentery; Gestation hemorrhage; Metrorrhagia; The vexed insomnia of the deficiency of YIN; Deficiency of the lung cough caused by dryness; The convulsion of stirring-up of pathogenic wind in the interior resulting from deficiency is fainted tic.Compendium of Material Medica is carried: " all syndrome caused by wind pathogen of men and women, arthralgia, aqueous vapor edema, cough due to consumptive disease dyspnea with rapid respiration, consumptive lung disease spitting bloody pus, and swollen ulcer drug.With blood YIN nourishing, except wind is moisturized, lung heat clearing of reducing phlegm, diuresis, tunes up intestinal." modern medicine study confirmation, Colla Corii Asini has powerful blood tonification effect, and curative effect is better than chalybeate, can regulate creatinine and creatine level, prevents vitamin E Oxidative demage, promotes positive calcium balance, prevents and treats progressive muscular dystrophy, also has raising blood pressure and Antishock function in addition.

The Radix Paeoniae Alba: bitter in the mouth; Property is put down.Enter liver; Spleen channel.Nourishing blood to suppress the hyperactive liver, pain relieving in slow; Yin fluid astringing receives antiperspirant.Cure mainly the breast abdomen pain over the hypochondriac region, dysentery is suffered from abdominal pain, spontaneous sweating, fever due to yin deficiency." not Lu " carries: " clear and coherent blood vessels, in slow, dispelling malignant blood, expelling extravasated blood, anhydrate gas, sharp bladder, intestine and small intestine, subduing inflammation, row cold and heat when controlling, and attacked by pestiferous factors is suffered from abdominal pain, lumbago." modern medicine study confirms; Radix Paeoniae Alba energy immunity moderation; strengthen macrophage and leukocytic phagocytic function; regulate the immunologic function of T lymphocyte and body fluid; protect the liver, spasmolytic, analgesia, calmness, anti-cool, cooling effect; have inhibitory action to smooth muscle in addition, strengthen the effect of anoxia enduring, antioxidation and resisting fatigue.

Radix Polygoni Multiflori: bitter in the mouth; Sweet; Puckery; Slightly warm in nature.Return liver; Kidney channel.Nourishing the blood and yin; Loosening bowel to relieve constipation; Preventing the attack (or recurrence) of malaria; Dispel the wind; Removing toxic substances.Cure mainly: blood deficiency Light-headedness; Cardiopalmus; Insomnia; The soreness of the waist and knees of the hepatic and renal YIN deficiency; Early whitening of beard and hair; Tinnitus; Seminal emission; Dryness of the intestine constipation; Chronic malaria body is empty; Rubella pruritus; Carbuncle sore; Scrofula; Hemorrhoid." book on Chinese herbal medicine is just ": the Radix Polygoni Multiflori, specially enters Liver and kidney, take a tonic or nourishing food to build up one's health Kidney-Yin, and taste is admittedly very thick, and slightly hold concurrently pained, property is then gentle, and the reason of all sealing Tibetan with the part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels meets, therefore can fill out beneficial vital essence, has negative and positive and puts down secret effect, and non-relatively the moon as Radix Rehmanniae is solidifying comparable.Good Gu meaning eliminating pathogen in the liver wind, be that the moon does not contain sun, water does not support wood, is cause the raw wind of edema with the liver involved, and this energy nourishing YIN, then control wind and first control blood, and blood wind is from going out, and also its institute is suitable.But this nourishes with endogenous wind stopping, must take for eliminating pathogen in the liver.

Semen Sesami Nigrum: sweet in the mouth; Property is put down.Return liver; Spleen; Kidney channel.Liver and kidney tonifying; The benefit that nourishes blood essence; Loosening bowel to relieve constipation.For dizziness and blurred vision, Hiccough and deaf, early whitening of beard and hair, post disease alopecia, dryness of the intestine constipation.Modern medicine study proves: Semen Sesami Nigrum has hypoglycemic activity, short adrenal gland's effect, antiinflammatory action and has certain effect to cardiovascular.

Rhizoma Polygoni Cuspidati: bitter in the mouth; Acid; Cold nature.Return liver; Gallbladder meridian.Promoting blood circulation to remove blood stasis; Dispelling wind and removing obstruction in the collateral; Clearing away heat-damp and promoting diuresis; Removing toxic substances.Cure mainly women's amenorrhea; Dysmenorrhea; Lochiostasis; Lumps in the chest and abdomen; Injury from falling down; Rheumatic arthralgia; Jaundice due to damp-heat; Stranguria with turbid discharge leukorrhagia; Sore swollen toxin; Venom; Burn due to hot liquid or fire." Mingyi Bielu " main tonneau moon water, broken Liu mass resulting from the blood stasis knot.

Rhizoma Cyperi: acrid in the mouth; Cold nature; Nontoxic.Return liver; Lung; Spleen; Stomach; Tri-jiao channel.To regulate the flow of vital energy resolving depression; Menstruction regulating and pain relieving; Antiabortive.Cure mainly distending pain over the hypochondrium; Mammary swelling is educated; Hernia pain; Menoxenia; Gastral cavity abdomen feeling of fullness pain; Belch acid regurgitation, vomiting and nausea; Abdominal pain during menstruation; Bleeding not during menses; Frequent fetal movement." the southern regions of the Yunnan Province book on Chinese herbal medicine ": adjust the gas in blood, dissipating depression of QI, alleviating distention in middle-JIAO, helps digestion, anti-nausea.

Herba Verbenae: bitter in the mouth; Pungent; Cold nature.Enter liver; Spleen channel.Heat-clearing and toxic substances removing; Promoting blood circulation to restore menstrual flow; Inducing diuresis to remove edema; Preventing the attack (or recurrence) of malaria.Cure mainly cold, fever; Laryngopharynx swelling and pain; Gingival swelling and pain; Jaundice; Dysentery; Blood stasis amenorrhea; Dysmenorrhea; WEIJIA; Edema; Dysuria; Malaria; Carbuncle pyogenic infections from tumour or sore; Traumatic injury." Tian Bao book on Chinese herbal medicine " carries: " diuresis, suppressing the hyperactive liver pathogenic fire purging.Control red skin ulcer, acute catarrhal conjunctivitis." modern medicine study shows, Herba Verbenae has intends parasympathetic effect, and water-ol extracting solution has antiinflammatory, analgesic activity, and contained venbenalin has inhibitory action to SNE excitement, can also alleviate lower part of the body edema in addition.

Caulis Polygoni Multiflori: sweet in the mouth; Micro-hardship; Property is put down.Enter the heart; Liver Channel.Tranquilizing by nourishing the heart; Dispel the wind; Dredging collateral.Cure mainly insomnia; Dreaminess; Blood deficiency general pain; Numbness of the skin; Rheumatic arthralgia; Rubella pruritus." decoction pieces is newly joined " carries: " nourishing the liver and kidney, only sweating due to debility, hypnosis of calming the nerves, invigorating middle warmer gas, network of passing through, promoting blood circulation, controls impairment caused by overstrain." modern medicine study confirmation, Caulis Polygoni Multiflori contains emodin, physcione, is synergism with pentobarbital sodium, has significant calmness, syngignoscism, especially extends S sleep phase.

Radix Rubiae: bitter in the mouth; Cold in nature.Return liver; The heart; Kidney; Spleen; Stomach; Pericardium channel.Cooling blood for hemostasis; Blood circulation promoting and blood stasis dispelling; Cure mainly heat in blood spitting of blood; Spit blood; Epistaxis; Hematuria; Have blood in stool; Metrorrhagia; Amenorrhea; Postpartum stagnation is suffered from abdominal pain; Traumatic injury; Rheumatic arthralgia; Jaundice; Carbuncle sore; Hemorrhoid swell." Bencao Jingshu " carries: " puerperal blood faints, breast knot, menstruation is more than, and hemorrhoidal hamorrhage hemorrhoid complicated by anal fistula, evacuation of pus, controls furuncle, lets out essence, hematuria, flutters damage blood stasis, all gets the capable sedan-chair of its removing heat from blood, the merit ear of clearing up internal heat by using drugs of bitter in taste and cold in nature for only serious epistaxis, leukorrhagia." modern medicine study confirmation; Radix Rubiae has certain inhibitory action to staphylococcus aureus, Staphylococcus albus, Hemolytic streptococcus, Diplococcus pneumoniae, micrococcus catarrhalis, hemophilus influenza; have inhibitory action to Bacillus tuberculosis; having reduces blood pressure but does not affect effect of heart; correct the blood coagulation disorders that heparin causes, have the effect of diuresis and excited intestine in vitro.

Herba Lycopi: acrid in the mouth; Micro-hardship; Property micro-wet.Return liver; Spleen channel.Promoting blood circulation to restore menstrual flow; Blood stasis dispelling row water.Cure mainly menoxenia; Dysmenorrhea; Amenorrhea; Puerperal abdonimal pain; WEIJIA; Body and face edema; Carbuncle; Traumatic injury." Chinese herbal medicine is commonly used in Sichuan " carries: " Herba Strobilanthis Japonici, the capable water of repercussive, soothing liver-QI falls apart strongly fragrant." modern medicine study confirms, Herba Strobilanthis Japonici containing volatile oil, tannin, phenols and several amino acids, can prevent thrombosis, have slight anticoagulant system with the effect strengthening fibrinolytic.

Semen Platycladi: sweet in the mouth; Property is put down.GUIXIN; Kidney; Large intestine channel.Tranquilizing by nourishing the heart; Arresting sweating; Loosening bowel to relieve constipation.Cure mainly palpitation with fear palpitation with a distress feeling; Insomnia forgetfulness; Night sweat; Dryness of the intestine constipation." medicineization justice " carries: " the saturating heart of fragrance, body profit grows blood, cures mainly mind void timid, and palpitation with fear palpitation with a distress feeling, color is wan and sallow, skin pruritus due to dryness, and the merit of the blood that all nourishes heart also." modern medicine study confirmation, Semen Platycladi contains a large amount of unsaturated fatty acid, a small amount of volatile oil and multivitamin, saponin, plant sterol and protein, improves immunity of organisms, is used for treatment ariant angina and rheumatic coronary heart disease.

Bodhi is fragrant: acrid in the mouth, sweet, and property is put down.Enriching yin and nourishing kidney, suppressing the hyperactive liver improving eyesight, reducing swelling and alleviating pain.Cure cold, dizziness headache, hypertension, anemia, chronic enterogastritis, menoxenia, mastitis, the diseases such as sore.

Rhizoma Curcumae: acrid in the mouth; Bitter; Warm in nature.Return liver; Spleen channel.Circulation of qi promoting removing blood stasis; Removing food stagnancy pain relieving.Cure mainly vim and vigour pained; Eating accumulation; Abdominal distention; Amenorrhea due to stagnation of blood; Dysmenorrhea; WEIJIA tumor mass in the abdomen; Traumatic injury." medicineization justice " carries: " acrid in the mouth is strong, specializes in the blood in gas, and main removing mass disappears heavily fortified point, goes to gather addiction block, amenorrhea blood stasis, flutters report pain." modern medicine study confirmation; the growth of Rhizoma Curcumae to multiple tumor strain has significantly suppression and destruction; have inhibitory action to tumor, the metabolism of cancerous cell core; significantly improve the content of lymphocytes in blood; strengthen oncocyte immunogenicity; temptation or promotion body, to the immunological rejection of tumor, improve the effect of radiation therapy.

Radix Glycyrrhizae: sweet in the mouth; Property is put down.GUIXIN; Lung; Spleen; Stomach warp.Invigorating the spleen and replenishing QI; Heat-clearing and toxic substances removing; Expelling phlegm for arresting cough; Relieving spasm to stop pain; Coordinating the actions of various ingredients in a prescription.Cure mainly weakness of the spleen and stomach; Fatigue and weakness; Shortness of breath and palpitation; Cough with copious phlegm; Gastral cavity abdomen four muscle spasm of the leg and foot pain; Carbuncle sore tumefacting virus; Cushion toxicity.Compendium of Material Medica is carried: " in all medicines, Radix Glycyrrhizae is monarch.Control 72 kinds of mammary calculus poison, draft is malicious by every means to separate 1,002, is in harmonious proportion from medicine and gains merit." modern medicine study confirmation; Radix Glycyrrhizae has stronger Detoxication; also have antiulcer, anti-inflammatory, spasmolytic antitussive, blood pressure lowering, blood fat reducing, antitumaous effect; be widely used in the diseases such as treatment pharyngolaryngitis, laryngitis, tracheitis, bronchitis, asthma, cough, hemoptysis, have anti-gastric-ulcer, gastritis effect in addition.

Fructus Leonuri: sweet in the mouth; Pungent; Cold nature; Mild toxicity.Enter Liver Channel.Promoting blood flow to regulate menstruation; Liver heat removing and eyesight improving.Cure mainly menoxenia; Dysmenorrhea; Amenorrhea; The stagnant stomachache of the stasis of blood in puerperal; Liver-heat is had a headache; Dizzy; Conjunctival congestion and swelling pain; The raw cataracta of order." Bencao Jingshu " carries: " large heat headache is vexed, and all the time of blood deficiency and heat also, liver heat removing heat radiation and blood, then vexed all solutions of having a headache." modern medicine study confirmation, Fructus Leonuri, containing leonurinine alkali, stachydrine, fatty oil, 17 seed amino acids and 24 kinds of mineral elements, has slight hypotensive effect, has the effect of inhibition paralysis to central nervous system.

The present invention compared with prior art, has following beneficial effect:

The present invention is selected obtains medical material, the property of medicine is suitable mutually auxiliary mutually, suit the remedy to the case for the cause of disease, there is effect of nourishing the liver nourishing kidney, nourishing YIN and clearing away heat, invigorating the spleen and regulating the stomach, vigorate qi and replenish the blood, resolving depression of regulating the flow of vital energy, promoting blood circulation to restore menstrual flow, tranquilizing by nourishing the heart, good absorbing effect, evident in efficacy, have no side effect and clinical adverse, higher to premature ovarian failure cure rate through clinical verification.

Detailed description of the invention

Below in conjunction with specific embodiment, the present invention is further elaborated.

Embodiment 1

The raw material composition of effective ingredient of the present invention and weight are:

The processing step of process for preparing medicine of the present invention is:

Usage and dosage: oral, every day 3 times, each 1 ball, one hour ante cibum, with warm water delivery service, 20 days was a course for the treatment of.

Embodiment 2

The process for preparing medicine processing step of the present embodiment and usage and dosage identical with embodiment 1.

Embodiment 3

Clinical data:

1, case selection

The routine clinical observation of chain reaction in patients with premature ovarian 50 selecting my institute to make a definite diagnosis, women, 33 ~ 41 years old age, 36.6 years old mean age.

2, patient takes medicine of the present invention, oral, every day 3 times, each 1 ball, and one hour ante cibum, with warm water delivery service, 20 days was a course for the treatment of, took 3 courses for the treatment of.

3, efficacy determination:

(1) cure: the clinical symptoms such as amenorrhea disappear substantially, and continuous more than 3 times menorrheas, ovarian function recovers normal substantially.

(2) take a turn for the better: the clinical symptoms such as amenorrhea are obviously alleviated, menstrual cycle is not yet normal, but ovarian function has clear improvement.

(3) invalid: symptom is with treating front no significant difference.

4, result

Patient treats through pill of the present invention, does not occur toxic and side effects and clinical adverse, cures 31 examples, and take a turn for the better 15 examples, invalid 4 examples, cure rate 62%, total effective rate 92%.

Above result display, pill of the present invention has good curative effect to premature ovarian failure.

Model case is illustrated:

1, Zhao's ××, female, 38 years old, office worker.This patient work's pressure ratio is comparatively large, and often work overtime, it is not in the period to find that there is 2 months in the recent period, pachylosis, insomnia irritability, institute's inquiring afterwards, is diagnosed as premature ovarian failure, after taking 2 courses for the treatment of of medicine of the present invention, readme above-mentioned symptom obviously alleviates, after continuing to take 1 course for the treatment of, carry out institute's check, clinical symptom disappearance, ovarian function recovery is normal, fully recovers.

2, what ××, female, 39 years old, teacher.There is spanomenorrhea in this patient, menstrual period do not have rule in the recent period, duration in menstrual period time short, the coarse drying of anxiety insomnia, skin quality, hectic fever hyperhidrosis, institute's inquiring afterwards, be diagnosed as premature ovarian failure, after taking 3 courses for the treatment of of medicine of the present invention, above-mentioned symptom disappears, ovarian function recovery is normal, fully recovers.

The present invention sums up configuration through Long-term clinical checking to form, and the property of medicine of selected medical material is suitable mutually auxiliary mutually, suits the remedy to the case for the cause of disease, and in side, the Chinese medicine such as musk orchid, bodhi perfume, Radix Tylophorae arenicolae can enriching yin and nourishing kidney; In side, the Chinese medicine such as Fructus Lycii, Fructus Corni, Semen Sesami Nigrum can liver and kidney tonifying; In side, the Rhizoma Atractylodis Macrocephalae can invigorating the spleen and benefiting QI; In side, the Chinese medicine such as the Radix Rehmanniae, Radix Polygoni Multiflori can nourishing the blood and yin, nourishing YIN and clearing away heat; In side the Radix Paeoniae Alba can nourishing blood to suppress the hyperactive liver, yin fluid astringing receive antiperspirant; In side, the Chinese medicine such as Flos Rosae Rugosae, Rhizoma Cyperi can be regulated the flow of vital energy resolving depression, regulating menstruation by adjusting the flow of blood; In side, Colla Corii Asini can nourishing YIN and supplementing blood; In side Radix potentillae anserinae can fill blood, strengthening the spleen and stomach; In side, the Chinese medicine such as Herba Lycopi, Radix Rubiae, Herba Verbenae can promoting blood circulation to restore menstrual flow, blood stasis dispelling row water; In side, the Chinese medicine such as Semen Platycladi, Caulis Polygoni Multiflori can tranquilizing by nourishing the heart; In side, Radix Glycyrrhizae can coordinating the actions of various ingredients in a prescription; In side, all medicines share the effect of playing nourishing the liver nourishing kidney, nourishing YIN and clearing away heat, invigorating the spleen and regulating the stomach, vigorate qi and replenish the blood, resolving depression of regulating the flow of vital energy, promoting blood circulation to restore menstrual flow, tranquilizing by nourishing the heart altogether, good absorbing effect, evident in efficacy, have no side effect and clinical adverse, higher to premature ovarian failure cure rate through clinical verification.

Claims

1. be used for the treatment of a medicine pill for premature ovarian failure, it is characterized in that, raw material composition and the parts by weight of making described effective ingredient are:

2. a kind of medicine pill being used for the treatment of premature ovarian failure according to claim 1, is characterized in that, raw material composition and the parts by weight of making described effective ingredient are:

3. a kind of medicine pill being used for the treatment of premature ovarian failure according to claim 1, is characterized in that, raw material composition and the parts by weight of making described effective ingredient are:

4. a kind of preparation method being used for the treatment of the medicine pill of premature ovarian failure as described in claims 1 to 3, is characterized in that, comprise following processing step: