CN107496688B - Traditional Chinese medicine composition for treating diabetes yin deficiency constipation - Google Patents

Abstract

The invention provides a traditional Chinese medicine composition for treating diabetes yin deficiency constipation, which is prepared from the following raw materials in parts by weight: 10-30 parts of radix rehmanniae recen, 10-20 parts of radix polygoni multiflori, 5-20 parts of angelica, 10-20 parts of mulberry, 6-20 parts of radix ophiopogonis, 10-20 parts of fructus cannabis, 10-20 parts of cistanche and 3-10 parts of ligusticum wallichii. The traditional Chinese medicine composition has the effects of nourishing yin and blood, increasing fluid and moistening intestines, activating stagnancy and relaxing bowels, is used for treating diabetes yin deficiency constipation, can relax bowels without damaging yin, and has better curative effect and no side effect after long-term administration.

Description

Traditional Chinese medicine composition for treating diabetes yin deficiency constipation

Technical Field

The invention belongs to the technical field of diabetes, and particularly relates to a traditional Chinese medicine composition for treating diabetes yin deficiency constipation.

Background

Diabetes and its complications have become a disease seriously affecting human health, and the symptoms of constipation due to yin deficiency frequently occur in clinic, which is one of the common complications of diabetes. Constipation can cause abdominal pain and abdominal distension, nausea, anorexia, dysphoria, insomnia, dreaminess and perineal distention, and can also cause hemorrhoids and anal fissure and increase perianal infection chances, thereby increasing the pain and economic burden of patients. In addition, in the middle-aged and elderly diabetic patients, the severe difficult-to-retrieve consequences such as cerebral vessel rupture, sudden death, intestinal rupture and perforation, blindness and the like can be caused by defecation force due to constipation.

However, in the prior art, there is no traditional Chinese medicine formula for treating diabetic constipation due to yin deficiency, and in actual treatment, the traditional Chinese medicine formula for treating constipation is generally used for relaxing bowels, which mainly takes purgation as the main treatment, and the existing prescriptions for treating constipation are listed as follows:

1. the fructus cannabis pill is sourced from Shanghai treatise on Cold-induced diseases, and comprises the following components in formula: 500g of edestan, 250g of peony, 250g of fructus aurantii (roasted), 500g of rhubarb (peeled), 250g of magnolia officinalis (roasted, peeled) and 250g of almond (peeled and sharpened, respectively used as grease).

The use method comprises the following steps: the medicines are all pulverized and are refined with honey into pills, such as the size of phoenix tree seed. 9g each time, and is taken with warm boiled water 1-2 times daily.

Treat deficiency of body fluid, dryness-heat in stomach and intestine, dry stool and frequent micturition.

The prescription is prepared by adding small chengqi decoction, and the compound of large chengqi decoction is prepared by using various nutrient solutions to nourish yin and moisten intestines without using hard masses softened by mirabilite, and has good curative effect.

2. The decoction for replenishing fluid and supporting qi comes from Wen Bing tiao Bian (differentiation of epidemic febrile disease), and has the following formula: 30g of radix scrophulariae, 9g of rheum officinale, 14g of radix ophiopogonis, 24g of fine dried rehmannia root and 4.5g of mirabilite.

The use method comprises the following steps: the medicine is decocted to obtain 1600mL, and then decocted to obtain 600mL, which is not taken again.

Treat the obstruction of the lower part due to the deficiency of body fluid, dry feces and no water retention in the boat.

The prescription is that the decoction is prepared by adding mirabilite and rhubarb into the decoction, the figwort root, the dried rehmannia root and the dwarf lilyturf tuber of the decoction are taken to nourish yin fluid and relax bowel, and the rhubarb and the mirabilite are used for clearing heat and softening hard masses and eliminating excess of internal organs to play the effects of nourishing yin and increasing fluid and clearing heat and relaxing bowel together.

The analysis of the above formulas shows that the formulas contain the drugs for removing food retention and clearing heat, such as rhubarb or mirabilite, which are applicable to common constipation patients, and have better effect in short-term taking and poor curative effect in long-term taking. However, constipation caused by diabetes exists for a long time along with diabetes, and due to the special pathological causes of diabetes, the prescription cannot play a therapeutic role but aggravates the symptoms of constipation due to yin deficiency after long-term use, and other medicines are difficult to play a curative effect at that time, so that the traditional constipation prescription is not suitable for the actual requirement of constipation due to yin deficiency of diabetes, and a prescription for constipation due to yin deficiency of diabetes patients needs to be found.

Disclosure of Invention

The invention aims at the treatment problem of diabetes yin deficiency constipation, provides a traditional Chinese medicine composition for treating diabetes yin deficiency constipation, combines all medicines to play the functions of nourishing yin and blood, increasing fluid and moistening intestines, activating stagnancy and relaxing bowels, treats the diabetes yin deficiency constipation, relaxes bowels without damaging yin, has better curative effect after long-term administration, and has no side effect.

The invention adopts the following technical scheme:

a traditional Chinese medicine composition for treating diabetes yin deficiency constipation is prepared from the following raw materials in parts by weight:

10-30 parts of radix rehmanniae recen, 10-20 parts of radix polygoni multiflori, 5-20 parts of angelica, 10-20 parts of mulberry, 6-20 parts of radix ophiopogonis, 10-20 parts of fructus cannabis, 10-20 parts of cistanche and 3-10 parts of ligusticum wallichii.

The medicines in the formula are food-grade safe and are all in a list of homologous varieties of medicine and food issued by the Ministry of health. Wherein, the dried rehmannia root, the raw tuber fleeceflower root, the angelica, the tuber of dwarf lilyturf, the Szechuan lovage rhizome, the mulberry and the fructus cannabis are listed in the list of the homology of medicine and food 2014 of the Ministry of health, and the cistanche is a limited variety in the list of homology of medicine and food. The medicine and food have the same grade, safety and no toxic or side effect, and are suitable for the actual requirement of long-term administration of diabetics.

Preferably, the traditional Chinese medicine composition can be prepared into any one of the pharmaceutical dosage forms suitable for clinical use.

Preferably, the pharmaceutical dosage form comprises pills, capsules and oral liquid.

Diabetes and its clinical manifestations belong to the category of "diabetes" in traditional Chinese medicine, and "diabetes" refers to the condition of allaying hunger and emaciation; thirst refers to thirst with profuse drinking and frequent urination. Emaciation and dry skin belonging to yin-blood deficiency; thirst and polyuria are due to deficiency of kidney yin. With the continuous and deep clinical research, the theory of traditional Chinese medicine is becoming more and more perfect, and the pathological changes of the viscera caused by the causes of the diseases recognize that yin deficiency and dryness heat are the main melody of diabetes (diabetes). Diabetes is apt to cause yin deficiency of the body and constipation due to yin deficiency. There are many discussions of constipation by physicians of all generations, and the "theory of etiology and the fourteenth book of difficult defecation" is: "thirst and easy home and defecate are difficult, so the term means that the body fluid is exhausted and causes the gastrointestinal dryness", which means that people with diabetes and diabetes are constipation due to the deficiency of body fluid and yin.

The Ming Zhang Xibin Jingyue quan Shu provides the treatment principle of constipation on the basis of the prior knowledge: the secret syndrome refers to the condition of dryness accumulation of the old, the weak, the yin-zang and the postpartum, after illness, after excessive sweating, excessive small water, or after blood loss, vomiting and diarrhea, which is usually caused by blood loss, blood deficiency and qi and blood deficiency, i.e., consumption of body fluid. For these reasons, it is necessary to carefully check the deficiency and excess, and not to use mirabilite, Da Huang, Ba Dou, Qian niu, Yuan Hua and Da Ji, etc. or to take qi-bearing and Shen Xiong, etc. Although the herbs are fast to pass today and strong deficiency causes deficiency, the root cause of exhaustion is that the accumulation in the tomorrow is more serious and no herb is available. Diabetes constipation is the dry stool caused by excessive small water and deficiency of yin fluid. The ma ziren wan and Zeng Lian Shu Cheng Qi Tang all have the action of inducing diuresis and purging, and are used for relieving the deficiency of yin and relaxing the bowels only temporarily in diabetes, so it is more necessary in tomorrow.

Square solution:

dried rehmannia root: sweet and bitter taste, cold nature, entering heart, liver and kidney channels, clearing heat and cooling blood, nourishing yin, and promoting fluid production, and can be used for treating fever polydipsia, macula, eruption, yin deficiency with internal heat, hematemesis, epistaxis, diabetes, and infectious hepatitis; the rehmannia contains effective components (R-BP-F), and experimental studies prove that the rehmannia can play a role in reducing blood sugar of patients with diabetes.

Chinese angelica: sweet, pungent and warm, entering heart, liver and spleen meridians, and used for abdominal pain due to deficiency-cold, constipation due to intestinal dryness; experiments show that the angelica powder (1.5g/kg) is orally taken, and has the function of reducing blood sugar for experimental hyperglycemia of rats and rabbits.

Mulberry: the beverage has sweet and sour taste and slightly cold nature, enters heart, liver and kidney channels, is a good fruit for nourishing heart, benefiting intelligence and nourishing and strengthening, has the efficacies of promoting the production of body fluid to quench thirst, replenishing blood, nourishing yin, moistening dryness of the intestine and the like, and is mainly used for treating symptoms such as tinnitus and palpitation, dizziness, soreness and weakness of waist and knees, dysphoria and insomnia, early white beard and hair, dry stool, diabetes, dry mouth and the like caused by yin and blood deficiency.

Raw fleece-flower root: sweet and bitter in taste, neutral in nature, enter heart, liver and large intestine channels, and are used for removing toxicity, curing carbuncle, moistening intestines and relaxing bowels.

Radix ophiopogonis: has sweet and slightly bitter taste and slightly cold nature, and can be used for treating lung dryness, dry cough, consumptive disease, cough, thirst due to body fluid consumption, vexation, insomnia, internal heat, diabetes, constipation due to intestinal dryness, and diphtheria due to pharynx; modern pharmacological research also shows that radix ophiopogonis mainly contains ophiopogonin, steroid saponin, alkaloid, sitosterol, glucose, amino acid, vitamin and the like, and has the effects of resisting fatigue, removing free radicals, improving cellular immune function and reducing blood sugar.

Cistanche deserticola: sweet and salty taste, warm nature, entering kidney and large intestine meridians, tonifying kidney yang, replenishing essence and blood, moistening intestine, and treating impotence, spermatorrhea, whitish and turbid urine, frequent micturition, lumbago, asthenia of feet, tinnitus, blurred vision, menstrual cycle, infertility due to cold womb, and constipation due to intestinal dryness due to deficiency of kidney yang and deficiency of essence and blood.

Fructus cannabis: sweet taste, neutral nature, entering spleen, stomach and large intestine meridians, and has the effect of relaxing bowel. It is commonly indicated for constipation due to intestinal dryness caused by blood deficiency and fluid deficiency.

The rhizome of Sichuan lovage is pungent in flavor: it is warm in nature, enters liver, gallbladder and heart channels, and has effects of promoting blood circulation, activating qi-flowing, dispelling pathogenic wind and relieving pain.

The method comprises the following steps: the prescription takes radix rehmanniae, angelica, mulberry and fresh polygonum multiflorum as the monarch, takes yin nourishing and blood nourishing of radix ophiopogonis and cistanche as the minister, takes fructus cannabis as the assistant for relaxing bowel, and takes ligusticum wallichii as the guide for tonifying qi and promoting qi and tonifying without stagnation. The raw rehmannia root, the Chinese angelica, the mulberry and the raw polygonum multiflorum are used as the source of yin nourishing and blood nourishing Uyushu, the dwarf lilyturf tuber, the cistanche and the fructus cannabis are used for increasing the liquid to moisten the intestines, such as increasing the water to go to the boat, and the szechuan lovage rhizome is used for tonifying qi and moving the qi like a boat, and is capable of relaxing the. The traditional Chinese medicine composition has the effects of nourishing yin and blood, increasing fluid and moistening intestines, activating stagnancy and relaxing bowels, is used for treating diabetes yin deficiency constipation, can relax bowels without damaging yin, and has better curative effect and no side effect after long-term administration.

Detailed Description

In order to make the technical purpose, technical solutions and advantageous effects of the present invention more clear, the technical solutions of the present invention are further described below with reference to specific embodiments.

Example 1: pill preparation

A traditional Chinese medicine composition for treating diabetes yin deficiency constipation is prepared from the following raw materials in parts by weight:

10-30 parts of radix rehmanniae recen, 10-20 parts of radix polygoni multiflori, 5-20 parts of angelica, 10-20 parts of mulberry, 6-20 parts of ophiopogon root, 10-20 parts of fructus cannabis, 10-20 parts of cistanche and 3-10 parts of ligusticum wallichii, and the method for preparing the pills comprises the following steps:

(1) taking the medicines according to the weight ratio, and crushing the medicines into 100-120 meshes of medicinal powder by using a medicinal crusher;

(2) sterilizing the medicinal powder obtained in the step (1) by adopting a Chinese patent medicine vacuum drying sterilization cabinet;

(3) adding semen Setariae, spraying water, adding medicinal powder, stirring, removing mold, repeatedly adding water, adding powder, rolling, sieving to obtain granules with size of common Firmiana simplex, covering, drying, and packaging.

The taking method comprises the following steps: three times a day, 20 granules once.

Example 2: capsule

A traditional Chinese medicine composition for treating diabetes yin deficiency constipation is prepared from the following raw materials in parts by weight:

10-30 parts of radix rehmanniae recen, 10-20 parts of radix polygoni multiflori, 5-20 parts of angelica, 10-20 parts of mulberry, 6-20 parts of ophiopogon root, 10-20 parts of fructus cannabis, 10-20 parts of cistanche and 3-10 parts of ligusticum wallichii, and the method for preparing the capsule comprises the following steps:

(1) taking the medicines according to the weight ratio, crushing the medicines by using a medicinal crusher, and crushing into 80-100 meshes of medicinal powder;

(2) sterilizing the medicinal powder obtained in the step (1) by adopting a Chinese patent medicine vacuum drying sterilization cabinet;

(3) and (4) storing the sterilized medicinal powder in a sterile workshop, preparing each capsule containing 0.5g of medicinal powder into a zero-grade capsule, filling the capsules into bottles, and sealing and storing the capsules for later use.

The taking method comprises the following steps: three times a day, 5 capsules once.

Example 3: oral liquid

A traditional Chinese medicine composition for treating diabetes yin deficiency constipation is prepared from the following raw materials in parts by weight:

the preparation method of the oral liquid comprises the following steps of preparing 200 g of radix rehmanniae recen, 100 g of radix polygoni multiflori, 200 g of angelica, 200 g of mulberry, 200 g of ophiopogon root, 200 g of fructus cannabis, 200 g of cistanche and 100 g of ligusticum wallichii:

(1) 1400 g of the medicines are taken according to the weight ratio and put into a non-woven fabric bag, the non-woven fabric bag is tied and put into a container, 4800mL of water is added, and the mixture is soaked for 30 minutes;

(2) decocting with an automatic decocting machine, bagging, and refrigerating in refrigerator (preservation time is no more than 1 week) with 190 mL/20 bags.

The taking method comprises the following steps: the medicine bag is soaked in boiling water before administration, and is administered orally when the temperature reaches a suitable value. Twice a day and one bag at a time.

Clinical efficacy test

Comparative example 1

The fructus cannabis pill comprises the following components in percentage by weight: 500g of edestan, 250g of peony, 250g of fructus aurantii (roasted), 500g of rhubarb (peeled), 250g of magnolia officinalis (roasted, peeled) and 250g of almond (peeled and sharpened, respectively used as grease).

Comparative example 2

The decoction for replenishing liquid and supporting qi comprises the following components: 30g of radix scrophulariae, 9g of rheum officinale, 14g of radix ophiopogonis, 24g of fine dried rehmannia root and 4.5g of mirabilite.

Comparative example 3

Chinese medicine capable of nourishing yin and relaxing bowels disclosed in patent CN00129139.4 is prepared from 24g of fleece-flower root, 24g of rehmannia root, 12g of Chinese angelica, 12g of dwarf lilyturf tuber, 12g of figwort root and 6g of bitter orange.

Comparative example 4

CN200510019922.8 discloses a traditional Chinese medicine for treating constipation, which is a medicament prepared from the following raw materials in parts by weight:

8-15 parts of bighead atractylodes rhizome, 5-10 parts of cistanche deserticola and 3-9 parts of angelica sinensis

2-8 parts of immature bitter orange, 2-8 parts of mulberry, 1-4 parts of aloe.

Taking the oral liquid prepared in the embodiment 3 of the invention as a treatment group, taking the comparative examples 1 to 4 as control groups, carrying out clinical tests in 2012 to 2016 at a hospital in Shangshui province in traditional Chinese medicine, selecting 110 patients with diabetes and constipation due to yin deficiency between 42 and 67 years old, randomly dividing the patients into 5 groups of 22 cases, wherein one group is the treatment group, taking the oral liquid prepared in the embodiment 3 according to the prescription dose, taking the other four groups as the control groups, taking the traditional Chinese medicine preparations in the comparative examples 1 to 4 according to the prescription dose, and tracking the treatment time to one year.

Clinical symptom diagnostic criteria:

diagnosis standard of diabetic yin deficiency constipation:

(1) defecating is strenuous, and defecating is not possible, dry and globular stool or hard stool. Feeling of incomplete defecation;

(2) the defecation frequency is less than 3 times per week, and more than 25 percent of time has defecation labor;

(3) prolonged transit time throughout the gastrointestinal tract or colon;

(4) prolonged illness, emaciation, and physical weakness;

(5) constipation caused by organic diseases is eliminated.

The therapeutic effect judgment standard is as follows:

and (3) curing: the excrement is not dry and is smooth to defecate, and the defecation is carried out once a day or once every other day;

the effect is shown: the defecation can be performed, the excrement is slightly dry, and the defecation time is obviously shortened;

the method has the following advantages: the defecation difficulty is improved compared with that before the medicine is taken;

and (4) invalidation: no improvement in symptoms.

In the clinical observation examination, the statistical results are as follows:

finally, it should be noted that: the above embodiments are merely illustrative and not restrictive of the technical solutions of the present invention, and any equivalent substitutions and modifications or partial substitutions made without departing from the spirit and scope of the present invention should be included in the scope of the claims of the present invention.

Claims (4)

1. The traditional Chinese medicine composition for treating diabetes yin deficiency constipation is characterized by being prepared from the following raw materials in parts by weight:

10-30 parts of radix rehmanniae recen, 10-20 parts of radix polygoni multiflori, 5-20 parts of angelica, 10-20 parts of mulberry, 6-20 parts of radix ophiopogonis, 10-20 parts of fructus cannabis, 10-20 parts of cistanche and 3-10 parts of ligusticum wallichii;

the traditional Chinese medicine composition is prepared into pills, capsules and oral liquid suitable for clinical use.

2. The traditional Chinese medicine composition for treating diabetic constipation due to yin deficiency as claimed in claim 1, wherein the method for preparing the pill is as follows:

(1) taking the medicines according to the weight ratio, and crushing the medicines into 100-120 meshes of medicinal powder by using a medicinal crusher;

(2) sterilizing the medicinal powder obtained in the step (1) by adopting a Chinese patent medicine vacuum drying sterilization cabinet;

(3) adding semen Setariae, spraying water, adding medicinal powder, stirring, removing mold, repeatedly adding water, adding powder, rolling, sieving to obtain granules with size of common Firmiana simplex, covering, drying, and packaging.

3. The traditional Chinese medicine composition for treating diabetic yin deficiency constipation according to claim 1, wherein the method for preparing the capsule is as follows:

(1) taking the medicines according to the weight ratio, and crushing the medicines into 80-100 meshes of medicinal powder by using a medicinal crusher;

(2) sterilizing the medicinal powder obtained in the step (1) by adopting a Chinese patent medicine vacuum drying sterilization cabinet;

(3) and (3) storing the sterilized medicinal powder in a sterile workshop, preparing each capsule containing 0.5g of medicinal powder into a zero-grade capsule, and filling the capsules into bottles for sealing and storing for later use.

4. The traditional Chinese medicine composition for treating diabetic yin deficiency constipation according to claim 1, which is prepared from the following raw materials in parts by weight:

the preparation method of the oral liquid comprises the following steps of preparing 200 g of radix rehmanniae recen, 100 g of radix polygoni multiflori, 200 g of angelica, 200 g of mulberry, 200 g of ophiopogon root, 200 g of fructus cannabis, 200 g of cistanche and 100 g of ligusticum wallichii:

(1) 1400 g of the medicines are taken according to the weight ratio and put into a non-woven fabric bag, the non-woven fabric bag is tied and put into a container, 4800mL of water is added, and the mixture is soaked for 30 minutes;

decocting with an automatic decocting machine, bagging, and refrigerating in a refrigerator for use, wherein each bag is 190mL by 20 bags.