CN105641344A - Medicinal preparation for treating constipation and application and preparing method of medicinal preparation - Google Patents

Medicinal preparation for treating constipation and application and preparing method of medicinal preparation Download PDF

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CN105641344A
CN105641344A CN201610035106.4A CN201610035106A CN105641344A CN 105641344 A CN105641344 A CN 105641344A CN 201610035106 A CN201610035106 A CN 201610035106A CN 105641344 A CN105641344 A CN 105641344A
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parts
fructus
radix
aloe
preparation
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王传秀
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Qingdao Yuntian Biotechnology Co Ltd
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Qingdao Yuntian Biotechnology Co Ltd
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
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    • A61K35/644—Beeswax; Propolis; Royal jelly; Honey
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    • A61K36/18—Magnoliophyta (angiosperms)
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Abstract

The invention relates to a medicinal preparation for treating constipation and application and a preparing method of the medicinal preparation. The medicinal preparation is prepared from, by weight, 20-50 parts of aloe, 8-17 parts of fructus cannabis, 5-11 parts of radix aucklandiae, 3-11 parts of fructus mume, 8-20 parts of semen cassiae, 5-15 parts of donkey-hide glue, 8-15 parts of bighead atractylodes rhizomes, 5-13 parts of licorice roots, 10-60 parts of yam, 3-8 parts of herba aristolochiae, 8-16 parts of radix trichosanthis, 8-20 parts of coriolus versicolor, 6-15 parts of chaenomeles sinensis(thouin) koehne, 3-11 parts of fructus terminaliae billericae and 10-25 parts of honey. The medicinal preparation is especially suitable for constipation, is a product for relaxing bowels and purging turbidity and expelling toxins, achieves the functions of relaxing bowels, purging turbidity and expelling toxins, and nourishing yin and benefiting qi under the joint action of assistance and guide, and is wider in application range. Through the embodiment 7, it is verified through pharmacological tests that the function of remarkably treating constipation can be achieved with a high dose group and a low dose group of traditional Chinese medicine capsules.

Description

A kind of for pharmaceutical preparation treating constipation and application thereof with preparation method
Technical field
The present invention relates to a kind of medical usage, be specifically related to a kind of pharmaceutical preparation being applied to treatment constipation and application thereof and preparation method, belong to field of medicaments.
Background technology
Irritable bowel syndrome (IBS) is one group to be continued or interval outbreak, changes into clinical manifestation with stomachache, abdominal distention, bowl evacuation habit and (or) stool, and lacks gastrointestinal tract structure and the function of intestinal canal disorder disease of biochemistry exception. Classical symptom is the stomachache relevant to abnormal defecation, abdominal distention, is divided into according to cardinal symptom: diarrhea predominance type; Constipation leading type; Alternating diarrhea and constipation type. The factors such as spirit, diet, cold can be lured symptom recurrence into or increase the weight of.
Onset of irritable bowel syndrome reason is extremely complex, and gastrointestinal motility disorder, visceral paraesthesia, Nervous and Mental Factors and intestinal infection are all probably the pathogenic factor of irritable bowel syndrome. At present clinical still medicine for irritable bowel syndrome has: (1) gastrointestinal antispasmodic medicine: anticholinergic agents is the most frequently used, still can partial agonist gastrocolic reflex and reduce enteral aerogenesis, alleviate and suffer from abdominal pain after the meal, calcium channel blocker such as nifedipine (nifedipine), pinaverium bromide. (2) gastrointestinal tract dynamia related drugs: loperamide, domperidone (motilium), cisapride etc. (3) cathartic: generally avoid using, but to serious constipation person can short-period used, first-selected hemicellulose or osmotic laxative treatments, take lactulose 15��30ml before sleeping, effect is also better, is particularly suited for old people. (4) psychotropic drugs: to the patient with obvious mental symptom, suitably gives tranquilizer, antidepressants, and antianxiety drugs has certain help. (5) eliminating gastrointestinal tract flatulence: simethicone, medicinal charcoal (activated carbon) has de-soak effect of cooling down, clinical conventional. (6) beneficial bacteria of intestinal tract: part diarrhea-type patient is likely to the disorder having intestinal microbial population, and application beneficial bacteria of intestinal tract class preparation is helpful. (7) other 5-HT4 acceptor portion excitomotors: tegaserod is effective to constipation type IBS, and can obviously improve the colic symptoms of patient, the IBS that diarrhoea is main by 5-HT3 receptor antagonist alosetron is effective. These medicines all can improve the symptom of irritable bowel syndrome in a short time, but long-term prescription poor effect, and in use procedure, these chemicalses have serious side effect more, make patient suffer untold misery.
At present, what treatment constipation adopted Chinese medicine is all a little eliminating fire and detoxication, the medicine of relieving constipation by purgation, and these medicines are for the inappetence of patient, and the symptom such as abdominal distention stomachache is difficult to alleviate.
Summary of the invention
For the defect of prior art, the present invention provides a kind of Chinese medicine preparation treating constipation, and it can treat constipation quickly and effectively, greatly reducing again the stimulation to intestinal and other physiological damage.
Specifically, the technical scheme is that and be achieved in that.
The present invention provides a kind of Chinese medicine preparation for treating constipation, and it is prepared by the Chinese medicinal components of following weight portion: Aloe 20-50 part, Fructus Cannabis 8-17 part, Radix Aucklandiae 5-11 part, Fructus Mume 3-11 part, Semen Cassiae 8-20 part, Colla Corii Asini 5-15 part, Rhizoma Atractylodis Macrocephalae 8-15 part, Radix Glycyrrhizae 5-13 part, Rhizoma Dioscoreae 10-60 part, Herba Aristolochiae 3-8 part, Radix Trichosanthis 8-16 part, Coriolous Dersicolor (Fr.) Quel 8-20 part, Fructus Chaenomelis 6-15 part, Fructus Terminaliae Billericae 3-11 part, Mel 10-25 part.
In Chinese medicine capsules described above, the Chinese medicine used all uses its conventional medicinal part to be used as medicine, the dosage of drug used is reasonable, improves effect to further enhance it, and described Chinese medicine granules also includes Radix Codonopsis 10-25 part, Radix Astragali 10-20 part and Fructus Aurantii Immaturus 5-15 part.
As a kind of embodiment preferred for this invention, described Chinese medicine composition is prepared by the Chinese medicinal components of following weight portion: Aloe 40 parts, Fructus Cannabis 13 parts, the Radix Aucklandiae 8 parts, Fructus Mume 7 parts, Semen Cassiae 14 parts, 10 parts of Colla Corii Asini, the Rhizoma Atractylodis Macrocephalae 11 parts, 9 parts of Radix Glycyrrhizae, Rhizoma Dioscoreae 35 parts, Herba Aristolochiae 6 parts, Radix Trichosanthis 12 parts, Coriolous Dersicolor (Fr.) Quel 14 parts, Fructus Chaenomelis 11 parts, Fructus Terminaliae Billericae 7 parts, Mel 18 parts, Radix Codonopsis 17 parts, the Radix Astragali 15 parts and Fructus Aurantii Immaturus 10 parts.
As another embodiment preferred for this invention, described Chinese medicine composition is prepared by the Chinese medicinal components of following weight portion: Aloe 37 parts, Fructus Cannabis 11 parts, the Radix Aucklandiae 7 parts, Fructus Mume 7 parts, Semen Cassiae 15 parts, 10 parts of Colla Corii Asini, the Rhizoma Atractylodis Macrocephalae 10 parts, 8 parts of Radix Glycyrrhizae, Rhizoma Dioscoreae 38 parts, Herba Aristolochiae 6 parts, Radix Trichosanthis 12 parts, Coriolous Dersicolor (Fr.) Quel 14 parts, Fructus Chaenomelis 11 parts, Fructus Terminaliae Billericae 7 parts, Mel 17 parts, Radix Codonopsis 17 parts, the Radix Astragali 15 parts and Fructus Aurantii Immaturus 10 parts.
According to theory of Chinese medical science, in the present invention, each raw-material effect is as follows:
Fructus Cannabis: sweet in the mouth, property is put down.
Gui Jing: return spleen, stomach, large intestine channel.
Function cures mainly: loosening bowel to relieve constipation. For blood deficiency and depleted fluid, dryness of the intestine constipation.
Fructus Mume gas is put down. Sour in the mouth. Nontoxic. The main therapeutic method to keep the adverse QI flowing downwards. Heat extraction. Stuffy sensation with restlessness. Feel at ease. Only limb pain
Rhizoma Dioscoreae: sweet in the mouth, property is put down.
Gui Jing: return spleen, lung, kidney channel.
Function cures mainly: spleen reinforcing nourishing the stomach, and promote the production of body fluid lung benefiting, the kidney invigorating arresting seminal emission. For insufficiency of the spleen lack of appetite, incessant chronic diarrhea, the deficiency of the lung is breathed with cough, emission due to deficiency of the kidney, leukorrhagia, frequent micturition, and deficiency-heat is quenched one's thirst. Rhizoma Dioscoreae (parched with bran) spleen reinforcing stomach invigorating. For insufficiency of the spleen lack of appetite, loose stool of having loose bowels, leukorrhagia. Herba Aristolochiae: acrid in the mouth, warm in nature.
Function cures mainly: expelling wind and removing dampness; Promoting flow of QI and blood. Main air pain of dampness syndrome; Epigastric pain; Traumatic injury Radix Trichosanthis Radix Trichosanthis, bitter in the mouth, cold in nature. Controlling lung abscess, evacuation of pus, disappear excessive thirst, only lung-heat, the traumatic injury that disappears blood stasis, the with the passing of time old expectorant yellow sputum in Qinghua, the therapeutic method to keep the adverse QI flowing downwards, solution sore, controls ulcerative carbuncle toxic swelling, and cough-relieving is coughed band blood.
Coriolous Dersicolor (Fr.) Quel: sweet in the mouth, cold in nature.
Gui Jing: liver; Spleen; Lung meridian
Function cures mainly: invigorating spleen to remove dampness; Relieving cough and asthma; Heat-clearing and toxic substances removing; Antitumor. Main chronic active hepatitis; Hepatitis interstitialis chronica; Chronic bronchitis; Bronchitis convulsiva; Laryngopharynx swelling and pain; Kinds of tumors; Rheumatoid arthritis; Leukemia.
Fructus Chaenomelis gas: temperature. Sour in the mouth. Nontoxic. Main arthralgia chiefly caused by damp pathogen tinea pedis. Cholera is told down greatly. Convulsion is more than. Fructus Chaenomelis temperature. Reporting the wood gas of sky spring sum, sour in the mouth is nontoxic.
Fructus Terminaliae Billericae: warm in nature, sour in the mouth.Main arthralgia chiefly caused by damp pathogen tinea pedis, cholera is told down greatly, and convulsion is more than, Fructus Chaenomelis temperature, reports the wood gas of sky spring sum.
Mel: sweet in the mouth, property is put down.
Gui Jing: return lung, spleen, large intestine channel.
Function cures mainly: invigorating middle warmer, moisturizes, pain relieving, removing toxic substances. For gastral cavity abdomen void pain, dryness of the lung dry cough, dryness of the intestine constipation; External treatment skin infection is not held back, burn due to hot liquid or fire.
Aloe: bitter in the mouth, cold in nature.
Gui Jing: return liver, stomach, large intestine channel.
Function cures mainly: the dizziness of Liver Channel excess-heat, headache, tinnitus, agitation, constipation, infantile convulsion, infantile malnutrition, catharsis and toxin expelling.
Mel: sweet in the mouth, property is put down.
Gui Jing: return lung, spleen, large intestine channel.
Function cures mainly: invigorating middle warmer is moisturized, analgesic antidotal, for gastral cavity abdomen void pain, dryness of the lung dry cough, dryness of the intestine constipation; External treatment skin infection is not held back, burn due to hot liquid or fire.
Semen Cassiae: sweet in the mouth, cold in nature.
Gui Jing: return liver, large intestine channel.
Function cures mainly: clearing away heat to improve acuity of vision, loosening bowel to relieve constipation. For the puckery pain of conjunctival congestion, the many tear of photophobia, dizziness of having a headache, poor vision, constipation.
Colla Corii Asini: sweet in the mouth, property is put down.
Gui Jing: return lung, liver, kidney channel.
Function cures mainly: YIN nourishing of enriching blood, and moisturizes hemostasis, and for blood deficiency and yellow complexion, dizziness cardiopalmus, flesh flaccidity is unable, dysphoria and insomnia, stirring-up of pathogenic wind in the interior resulting from deficiency, xeropulmonary cough, and chronic cough is spat blood, haematemesis hematuria, metrorrhagia of having blood in stool, vaginal bleeding during pregnancy.
The Rhizoma Atractylodis Macrocephalae: bitter in the mouth, warm in nature.
Gui Jing: return spleen, stomach warp.
Function cures mainly: invigorating the spleen and benefiting QI, dampness diuretic, and hidroschesis is antiabortive. For insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement.
Radix Glycyrrhizae: sweet in the mouth, property is put down.
Gui Jing: enter spleen, stomach, the heart, lung meridian.
Function cures mainly: invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain.
The Radix Aucklandiae: sweet in the mouth, warm in nature.
Gui Jing: return spleen, stomach, large intestine, gallbladder meridian.
Function cures mainly: can lead to manner, easing stomach-QI, row irritability, dissipates stagnant gas, broken stagnation of QI, and only distressed, by cold air, peace cholera is vomited and diarrhoea, and vomiting regurgitation of food from the stomach, except painful abdominal mass addiction disease block, umbilicus abdominal distention and pain, antiabortive scattered poison, is controlled dysentery required, and warded off pestilential pathogen miasma.
Fructus Aurantii Immaturus: bitter in the mouth, warm in nature.
Gui Jing: return spleen, stomach warp.
Function cures mainly: dispelling the stagnated QI removing food stagnancy, scattered painful abdominal mass of reducing phlegm, and stops, feeling of fullness distending pain in stagnant, weight, constipation, the stagnant vapour lock thoracic obstruction of expectorant, blocked-up chest after dysentery.
The Radix Astragali: sweet in the mouth, warm in nature.
Gui Jing: return lung, spleen channel.
Function cures mainly: invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, expelling pus and promoting granulation. Weak for the deficiency of vital energy, anorexia and loose stool, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, deficiency of vital energy edema, carbuncle difficulty is burst, and bursts for a long time and does not hold back, blood deficiency dull yellowish colored skin, and interior-heat is quenched one's thirst; Chronic nephritis proteinuria, diabetes.
Chinese medicine preparation of the present invention can be the pharmaceutically acceptable dosage forms such as capsule, oral administration solution, tablet. Present invention also offers a kind of preparation method treating constipation capsule, its preparation process includes as follows:
(1) corresponding raw material components is weighed according to weight standby;
(2) Colla Corii Asini, Radix Codonopsis, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae and Radix Glycyrrhizae wear into fine powder, cross 80-100 order and shine, standby;
(3) Semen Cassiae, Herba Aristolochiae, Radix Trichosanthis, Coriolous Dersicolor (Fr.) Quel, Fructus Cannabis, Fructus Terminaliae Billericae and Radix Aucklandiae employing alcohol extracting method, 75% ethanol backwash 1-3 time, each 1-3 hour, medicinal liquid filters, reclaims ethanol, 60-80 DEG C, it is evaporated to the extractum that relative density is 1.05, standby;
(4) by Aloe, Fructus Mume, Rhizoma Dioscoreae, Fructus Aurantii Immaturus, Fructus Chaenomelis and Mel, add the pure water of 6-12 times of volume, decoct secondary, 1.5 hours first times, second time 0.5 hour, collecting decoction, filter, be evaporated to the extractum that relative density is 1.10, standby;
(5) extractum in step (3) and step (4) is taken, add the fine powder of step (2), measure its weight, add the sucrose of its weight 10-30% and the mixture of dextrin, stir heating to 80��90 DEG C, cross 80 mesh sieves, prepare extract powder with spray dryer, load capsule.
In said method, sucrose and dextrin weight ratio described in step (5) are 1:1.
Capsule weight 0.5-1g in said method, described in step (5).
The present invention also provides for a kind of medical usage of above-mentioned Chinese medicine preparation, namely described Chinese medicine preparation purposes in preparation constipation medicine.
Compared with prior art, the present invention main advantage when treating constipation shows:
(1) we are particularly suited for constipation, the present invention at loosening bowel to relieve constipation, rush down turbid toxin expelling articles for use, monarch is various, plays loosening bowel to relieve constipation altogether, rushes down turbid toxin expelling, the merit of Replenishing QI and nourishing YIN, the scope of application is wider, and the embodiment of the present invention 7 is it will be seen that confirm through pharmacodynamics test, Chinese medicine capsules dosage group high, middle all can be readily apparent that the function for the treatment of constipation, is better than prior art.
(2) the preparation process technique of granule of the present invention is simple, easy to operate applicable industrialized great production.
Detailed description of the invention
Further describing the present invention below by way of specific embodiment, the present invention is not limited only to following example. Within the scope of the invention or without departing from present disclosure, spirit and scope, change, combination or the replacement that the present invention is carried out, will be apparent to the person skilled in the art, and be included within the scope of the present invention.
Embodiment 1: a kind of capsule treating constipation, containing the Chinese crude drug of following weight portion:
Aloe 20 parts, Fructus Cannabis 8 parts, the Radix Aucklandiae 5 parts, Fructus Mume 3 parts, Semen Cassiae 8 parts, 5 parts of Colla Corii Asini, the Rhizoma Atractylodis Macrocephalae 8 parts, 5 parts of Radix Glycyrrhizae, Rhizoma Dioscoreae 10 parts, Herba Aristolochiae 3 parts, Radix Trichosanthis 8 parts, Coriolous Dersicolor (Fr.) Quel 8 parts, Fructus Chaenomelis 6 parts, Fructus Terminaliae Billericae 3 parts, Mel 10 parts, Radix Codonopsis 10 parts, the Radix Astragali 10 parts and Fructus Aurantii Immaturus 5 parts.
Concrete preparation method is:
(1) corresponding raw material components is weighed according to weight standby;
(2) Colla Corii Asini, Radix Codonopsis, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae and Radix Glycyrrhizae wear into fine powder, cross 80-100 order and shine, standby;
(3) Semen Cassiae, Herba Aristolochiae, Radix Trichosanthis, Coriolous Dersicolor (Fr.) Quel, Fructus Cannabis, Fructus Terminaliae Billericae and Radix Aucklandiae employing alcohol extracting method, 75% ethanol backwash 1-3 time, each 1-3 hour, medicinal liquid filters, reclaims ethanol, 60-80 DEG C, it is evaporated to the extractum that relative density is 1.05, standby;
(4) by Aloe, Fructus Mume, Rhizoma Dioscoreae, Fructus Aurantii Immaturus, Fructus Chaenomelis and Mel, add the pure water of 6-12 times of volume, decoct secondary, 1.5 hours first times, second time 0.5 hour, collecting decoction, filter, be evaporated to the extractum that relative density is 1.10, standby;
(5) extractum in step (3) and step (4) is taken, add the fine powder of step (2), measure its weight, add the sucrose of its weight 10-30% and the mixture (sucrose and dextrin weight ratio are 1:1) of dextrin, stir heating to 80��90 DEG C, crosses 80 mesh sieves, prepare extract powder with spray dryer, load capsule, capsule weight 0.5-1g.
Embodiment 2: a kind of capsule treating constipation, containing the Chinese crude drug of following weight portion:
Aloe 50 parts, Fructus Cannabis 17 parts, the Radix Aucklandiae 11 parts, Fructus Mume 11 parts, Semen Cassiae 20 parts, 15 parts of Colla Corii Asini, the Rhizoma Atractylodis Macrocephalae 15 parts, 13 parts of Radix Glycyrrhizae, Rhizoma Dioscoreae 60 parts, Herba Aristolochiae 8 parts, Radix Trichosanthis 16 parts, Coriolous Dersicolor (Fr.) Quel 20 parts, Fructus Chaenomelis 15 parts, Fructus Terminaliae Billericae 11 parts, Mel 25 parts, Radix Codonopsis 25 parts, the Radix Astragali 20 parts and Fructus Aurantii Immaturus 15 parts.
Preparation method is with embodiment 1.
Embodiment 3: a kind of capsule treating constipation, containing the Chinese crude drug of following weight portion:
Aloe 40 parts, Fructus Cannabis 13 parts, the Radix Aucklandiae 8 parts, Fructus Mume 7 parts, Semen Cassiae 14 parts, 10 parts of Colla Corii Asini, the Rhizoma Atractylodis Macrocephalae 11 parts, 9 parts of Radix Glycyrrhizae, Rhizoma Dioscoreae 35 parts, Herba Aristolochiae 6 parts, Radix Trichosanthis 12 parts, Coriolous Dersicolor (Fr.) Quel 14 parts, Fructus Chaenomelis 11 parts, Fructus Terminaliae Billericae 7 parts, Mel 18 parts, Radix Codonopsis 17 parts, the Radix Astragali 15 parts and Fructus Aurantii Immaturus 10 parts.
Preparation method is with embodiment 1.
Embodiment 4: a kind of capsule treating constipation, containing the Chinese crude drug of following weight portion:
Aloe 37 parts, Fructus Cannabis 11 parts, the Radix Aucklandiae 7 parts, Fructus Mume 7 parts, Semen Cassiae 15 parts, 10 parts of Colla Corii Asini, the Rhizoma Atractylodis Macrocephalae 10 parts, 8 parts of Radix Glycyrrhizae, Rhizoma Dioscoreae 38 parts, Herba Aristolochiae 6 parts, Radix Trichosanthis 12 parts, Coriolous Dersicolor (Fr.) Quel 14 parts, Fructus Chaenomelis 11 parts, Fructus Terminaliae Billericae 7 parts, Mel 17 parts, Radix Codonopsis 17 parts, the Radix Astragali 15 parts and Fructus Aurantii Immaturus 10 parts.
Preparation method is with embodiment 1.
Embodiment 5: a kind of capsule treating constipation, containing the Chinese crude drug of following weight portion:
Aloe 20 parts, Fructus Cannabis 8 parts, the Radix Aucklandiae 5 parts, Fructus Mume 3 parts, Semen Cassiae 8 parts, 5 parts of Colla Corii Asini, the Rhizoma Atractylodis Macrocephalae 8 parts, 5 parts of Radix Glycyrrhizae, Rhizoma Dioscoreae 10 parts, Herba Aristolochiae 3 parts, Radix Trichosanthis 8 parts, Coriolous Dersicolor (Fr.) Quel 8 parts, Fructus Chaenomelis 6 parts, Fructus Terminaliae Billericae 3 parts, Mel 10 parts.
Concrete preparation method is:
(1) corresponding raw material components is weighed according to weight standby;
(2) Colla Corii Asini, the Rhizoma Atractylodis Macrocephalae and Radix Glycyrrhizae wear into fine powder, cross 80-100 order and shine, standby;
(3) Semen Cassiae, Herba Aristolochiae, Radix Trichosanthis, Coriolous Dersicolor (Fr.) Quel, Fructus Cannabis, Fructus Terminaliae Billericae and Radix Aucklandiae employing alcohol extracting method, 75% ethanol backwash 1-3 time, each 1-3 hour, medicinal liquid filters, reclaims ethanol, 60-80 DEG C, it is evaporated to the extractum that relative density is 1.05, standby;
(4) by Aloe, Fructus Mume, Rhizoma Dioscoreae, Fructus Chaenomelis and Mel, add the pure water of 6-12 times of volume, decoct secondary, 1.5 hours first times, second time 0.5 hour, collecting decoction, filter, be evaporated to the extractum that relative density is 1.10, standby;
(5) extractum in step (3) and step (4) is taken, add the fine powder of step (2), measure its weight, add the sucrose of its weight 10-30% and the mixture (sucrose and dextrin weight ratio are 1:1) of dextrin, stir heating to 80��90 DEG C, crosses 80 mesh sieves, prepare extract powder with spray dryer, load capsule, capsule weight 0.5-1g.
Embodiment 6: a kind of capsule treating constipation, containing the Chinese crude drug of following weight portion:
Aloe 50 parts, Fructus Cannabis 17 parts, the Radix Aucklandiae 11 parts, Fructus Mume 11 parts, Semen Cassiae 20 parts, 15 parts of Colla Corii Asini, the Rhizoma Atractylodis Macrocephalae 15 parts, 13 parts of Radix Glycyrrhizae, Rhizoma Dioscoreae 60 parts, Herba Aristolochiae 8 parts, Radix Trichosanthis 16 parts, Coriolous Dersicolor (Fr.) Quel 20 parts, Fructus Chaenomelis 15 parts, Fructus Terminaliae Billericae 11 parts, Mel 25 parts, Radix Codonopsis 25 parts.
Preparation method is with embodiment 5.
Embodiment 7: a kind of capsule treating constipation, containing the Chinese crude drug of following weight portion:
Aloe 40 parts, Fructus Cannabis 13 parts, the Radix Aucklandiae 8 parts, Fructus Mume 7 parts, Semen Cassiae 14 parts, 10 parts of Colla Corii Asini, the Rhizoma Atractylodis Macrocephalae 11 parts, 9 parts of Radix Glycyrrhizae, Rhizoma Dioscoreae 35 parts, Herba Aristolochiae 6 parts, Radix Trichosanthis 12 parts, Coriolous Dersicolor (Fr.) Quel 14 parts, Fructus Chaenomelis 11 parts, Fructus Terminaliae Billericae 7 parts, Mel 18 parts.
Preparation method is with implementing 5.
Embodiment 8: a kind of capsule treating constipation, containing the Chinese crude drug of following weight portion:
Aloe 37 parts, Fructus Cannabis 11 parts, the Radix Aucklandiae 7 parts, Fructus Mume 7 parts, Semen Cassiae 15 parts, 10 parts of Colla Corii Asini, the Rhizoma Atractylodis Macrocephalae 10 parts, 8 parts of Radix Glycyrrhizae, Rhizoma Dioscoreae 38 parts, Herba Aristolochiae 6 parts, Radix Trichosanthis 12 parts, Coriolous Dersicolor (Fr.) Quel 14 parts, Fructus Chaenomelis 11 parts, Fructus Terminaliae Billericae 7 parts, Mel 17 parts.
Preparation method is with embodiment 5.
Embodiment 9: a kind of oral administration solution treating constipation, containing the Chinese crude drug of following weight portion:
Aloe 40 parts, Fructus Cannabis 13 parts, the Radix Aucklandiae 8 parts, Fructus Mume 7 parts, Semen Cassiae 14 parts, 10 parts of Colla Corii Asini, the Rhizoma Atractylodis Macrocephalae 11 parts, 9 parts of Radix Glycyrrhizae, Rhizoma Dioscoreae 35 parts, Herba Aristolochiae 6 parts, Radix Trichosanthis 12 parts, Coriolous Dersicolor (Fr.) Quel 14 parts, Fructus Chaenomelis 11 parts, Fructus Terminaliae Billericae 7 parts, Mel 18 parts.
Preparation technology: said herbal medicine adds the pure water of 8-12 times of volume, decocts secondary, 1.5 hours first times, second time 0.5 hour, collecting decoction, filter, it is evaporated to the extractum that relative density is 1.10, dry, it is dissolved in the purified water of 1000ml, after adding 150 grams of sucrose of preparation and 2 grams of sodium benzoate stirring and dissolving, adds purified water to preparing total amount, filter to the qualified rear fill of clarity 100, specification is that 10ml/ props up, 100 DEG C of flowing steam sterilizations 60 minutes, packs and get final product.
Embodiment 10: a kind of oral administration solution treating constipation, containing the Chinese crude drug of following weight portion:
Aloe 37 parts, Fructus Cannabis 11 parts, the Radix Aucklandiae 7 parts, Fructus Mume 7 parts, Semen Cassiae 15 parts, 10 parts of Colla Corii Asini, the Rhizoma Atractylodis Macrocephalae 10 parts, 8 parts of Radix Glycyrrhizae, Rhizoma Dioscoreae 38 parts, Herba Aristolochiae 6 parts, Radix Trichosanthis 12 parts, Coriolous Dersicolor (Fr.) Quel 14 parts, Fructus Chaenomelis 11 parts, Fructus Terminaliae Billericae 7 parts, Mel 17 parts.
Preparation method is with embodiment 9.
Embodiment 11: a kind of tablet treating constipation, containing the Chinese crude drug of following weight portion:
Aloe 40 parts, Fructus Cannabis 13 parts, the Radix Aucklandiae 8 parts, Fructus Mume 7 parts, Semen Cassiae 14 parts, 10 parts of Colla Corii Asini, the Rhizoma Atractylodis Macrocephalae 11 parts, 9 parts of Radix Glycyrrhizae, Rhizoma Dioscoreae 35 parts, Herba Aristolochiae 6 parts, Radix Trichosanthis 12 parts, Coriolous Dersicolor (Fr.) Quel 14 parts, Fructus Chaenomelis 11 parts, Fructus Terminaliae Billericae 7 parts, Mel 18 parts.
Preparation technology: said herbal medicine adds the pure water of 8-12 times of volume, decocts secondary, 1.5 hours first times, second time 0.5 hour, collecting decoction, filter, it is evaporated to the extractum that relative density is 1.10, dry, cross after 80 mesh sieves and lactose, microcrystalline Cellulose mix homogeneously, with 50% ethanol soft material, cross 20 mesh sieves to granulate, forced air drying under 60 DEG C of conditions, 20 mesh sieve granulate, it is subsequently adding sodium carboxymethyl cellulose and the magnesium stearate mix homogeneously tabletting of recipe quantity, altogether system 1000.
Embodiment 12: a kind of tablet treating constipation, containing the Chinese crude drug of following weight portion:
Aloe 37 parts, Fructus Cannabis 11 parts, the Radix Aucklandiae 7 parts, Fructus Mume 7 parts, Semen Cassiae 15 parts, 10 parts of Colla Corii Asini, the Rhizoma Atractylodis Macrocephalae 10 parts, 8 parts of Radix Glycyrrhizae, Rhizoma Dioscoreae 38 parts, Herba Aristolochiae 6 parts, Radix Trichosanthis 12 parts, Coriolous Dersicolor (Fr.) Quel 14 parts, Fructus Chaenomelis 11 parts, Fructus Terminaliae Billericae 7 parts, Mel 17 parts.
Preparation method is with embodiment 12.
Embodiment 13: animal pharmacodynamics test
13.1, animal model and administration
Animal model: Kunming mouse 10, male and female dual-purpose, body weight 180-220g, is raised precedently in advance three and adapts to environment, on pretreatment animal fasting 24h (freely drinking water), and on-test, model group gives compound diphenoxylate by 25mg/kg, continuous 4 days.
Take ICR mice 50, male, it is randomly divided into 6 groups, often group 10. Dosage group (4.4g/kg), Chinese medicine capsules low dose group (2.2g/kg) in Normal group, model group, phenolphthalein tablets group (35mg/kg), Chinese medicine capsules high dose group (8.8g/kg), Chinese medicine capsules, often group 10; Wherein take the charcoal end aqueous solution medicinal liquid that the embodiment of the present invention 3 capsule is with 10%, as large, medium and small dosage group, phenolphthalein tablets is configured to 0.20mg/ml with the charcoal end aqueous solution of 10%, by 10ml/kg gastric infusion, phenolphthalein tablets 35mg/kg is as test positive drug control group, and blank group gives the charcoal end aqueous solution of the 10% of same volume.After gavage 30min, respectively group mice all gives charcoal end suspension oral gavage (0.1ml/10g), and after 20min, de-cervical vertebra puts to death animal, takes out the whole section of small intestinal from pylorus to ileocecus, the distance that measurement small intestinal total length and forward position, charcoal end advance at little enteral.
Distance (cm)/small intestinal total length (cm) �� 100% that charcoal end propelling rate %=charcoal end is carried out at little enteral
The impact of Mouse Stomach enterokinesia respectively organized by table 1
Packet n Charcoal end propelling rate (%)
Normal group 10 52.2��3.6$$
Model group 10 26.71��7.69**
Positive controls 10 53.8��4.4* $$
Low group of Chinese medicine capsules 10 55.7��3.2* $$
Group in Chinese medicine capsules 10 59.4��3.7* $$#
Chinese medicine capsules high group 10 62.9��5.1* $$##
Note:
Compared with Normal group,*P < 0.05,**P < 0.01;
Compared with model control group,$P < 0.05,$$P < 0.01;
Compared with positive controls,#P < 0.05,##P < 0.01;
Show from the result of table 1, model group is compared with Normal group, there is significant difference (P < 0.01), Constipation Model mice modeling success, positive controls and Chinese medicine capsules all can improve normal mouse charcoal end propelling rate, wherein each group of Chinese medicine capsules has the difference of significance compared with Normal group. Compared with positive controls, each group of Chinese medicine capsules to normal mouse charcoal end propelling rate improve effect more notable, especially group and Chinese medicine capsules high group in Chinese medicine capsules, it has the difference (P < 0.05 or P < 0.01) of significance compared with positive controls. It can thus be seen that Chinese medicine capsules of the present invention can remarkably promote the gastrointestinal peristalsis of normal mouse.
Embodiment 14: invention formulation promotes the research of normal ICR mice defecation
14.1, animal model and administration
Animal model: Kunming mouse 60, male and female dual-purpose, body weight 180-220g, it is raised precedently in advance three and adapts to environment, each treated animal fasting 24h (freely drinking water) on pretreatment, on-test, model group, positive group (phenolphthalein tablets) and 3 dosage groups of invention formulation all give compound diphenoxylate by 25mg/kg, blank group gives equal-volume distilled water, continuous 4 days.
Administration: mice is randomly divided into 6 groups: dosage group (4.4g/kg), Chinese medicine capsules low dose group (2.2g/kg) in Normal group, model group, phenolphthalein tablets group (35mg/kg), Chinese medicine capsules high dose group (8.8g/kg), Chinese medicine capsules, often group 10; Wherein take the charcoal end aqueous solution medicinal liquid that the embodiment of the present invention 3 capsule is with 10%, as large, medium and small dosage group, phenolphthalein tablets is configured to 0.20mg/ml with the charcoal end aqueous solution of 10%, by 10ml/kg gastric infusion, phenolphthalein tablets 35mg/kg is as test positive drug control group, and blank group gives the charcoal end aqueous solution of the 10% of same volume. After gavage 30min, each group mice all gives charcoal end suspension oral gavage (0.1ml/10g), mice is individually placed in metabolic cage and observes, discharge the time of melena when record is given activated carbon by mice first to mice, in 8h, mice discharges the number of melena and the quality of melena.
14.2, experimental result: as shown in table 2.
The impact on ICR mice defecation of table 2 Chinese medicine capsules
Note:
Compared with Normal group,*P < 0.05,**P < 0.01;
Compared with model control group,$P < 0.05,$$P < 0.01;
Compared with positive controls,#P < 0.05,##P < 0.01;
As can be seen from Table 2, model group is compared with Normal group, there is the significance difference opposite sex (P < 0.01), the success of modeling mice, positive controls and Chinese medicine capsules all can increase row's melena number and row's melena quality in 8h, and wherein each group of Chinese medicine capsules has the difference of significance compared with Normal group.Compared with positive controls, each group of Chinese medicine capsules to normal mouse defecation number and defecation mass effect more notable (P < 0.05 or P < 0.01), especially group and Chinese medicine capsules high group in Chinese medicine capsules, it has the difference (P < 0.05 or P < 0.01) of significance compared with positive controls.
Embodiment 15: clinical trial
In order to verify the clinical effectiveness of the present invention further, within 2012, receive 442 example constipation patients so far altogether, age 40-70 year, the mean age is 55.5 years old, and men and women half and half, and constipation is had significant curative effect by this Chinese medicine preparation, above-mentioned infant is carried out treatment follow the trail of statistics.
15.1, packet and administering mode
Treat 1. group: 147 examples, male 73 examples, female 74 example, take the capsule of the embodiment of the present invention 3, twice on the one, each 2,7 days be a course for the treatment of;
Treat 2. group: 147 examples, male 73 examples, female 74 example, take the capsule of the embodiment of the present invention 4, twice on the one, each 2,7 days be a course for the treatment of;
Observation group: 148 example men and women half and half, seven-star tea granule, three times on the one, half bag, 7 days is a course for the treatment of 1 every time.
15.2, diagnostic criteria
In 12 middle of the month in past, continue or accumulation at least 12 be all and has following 2 or more than 2 symptoms:
4 times stool is Overexertion at least one times
Sensation emptying is not smooth at least one times for 4 stool
4 stool are hard stalk or graininess at least one times
4 times stool has anorectal obstruction sense at least one times or blocks sense
4 times stool needs maneuver to help at least one times
Times of defecation is less than 3 times weekly, day feces volume be absent from loose stool less than 35 grams, do not meet the diagnostic criteria of IBS yet.
15.3, curative effect diagnosis and clinical effectiveness
Recovery from illness: free movement of the bowels, matter is soft, and pain, abdominal distention, inappetence symptom all eliminate;
Effective: defecating more unobstructed, matter is softer, painless, abdominal distention, inappetence symptom substantially eliminate;
Invalid: not improve with original the same;
Recurrence: recovery from illness and the effective individuality recurred again;
Effective percentage: (recovery from illness+effective)/this group infant sum.
Taking through two courses for the treatment of continuously, 1. treatment group organizes recovery from illness is 74 examples, and effective is 72 examples, invalid 1 example, treatment group 2. group, individual 68 examples of fully recovering, effective individual 76 examples, and invalid individuality is 3 examples; Observation group fully recovers 58 examples, and effective 779 examples, invalid 11 examples, concrete outcome is in Table 3.
The treatment situation of table 3 treatment group and observation group
Group Recovery from illness Effective Invalid Effective percentage (%) Recurrence
Treat 1. group 74 72 1 99.3 3
Treat 2. group 68 76 3 98.0 5
Observation group 58 79 11 92.6 17
442 above-mentioned infants are tracked investigation, treatment group only has 2 examples and laxativeness phenomenon occurs, and phenomenon of suffering from diarrhoea after drug withdrawal disappears, and there are 5 infant laxativeness in observation group, there is skin pruritus, causalgia phenomenon in 5 infants, illustrate that prescription safety of the present invention is higher.

Claims (10)

1. for treating a pharmaceutical preparation for constipation, including the Chinese medicine of following weight portion: Aloe 20-50 part, Fructus Cannabis 8-17 part, Radix Aucklandiae 5-11 part, Fructus Mume 3-11 part, Semen Cassiae 8-20 part, Colla Corii Asini 5-15 part, Rhizoma Atractylodis Macrocephalae 8-15 part, Radix Glycyrrhizae 5-13 part, Rhizoma Dioscoreae 10-60 part, Herba Aristolochiae 3-8 part, Radix Trichosanthis 8-16 part, Coriolous Dersicolor (Fr.) Quel 8-20 part, Fructus Chaenomelis 6-15 part, Fructus Terminaliae Billericae 3-11 part, Mel 10-25 part.
2. pharmaceutical preparation as claimed in claim 1, it is characterised in that described Chinese medicine also includes Radix Codonopsis 10-25 part, Radix Astragali 10-20 part and Fructus Aurantii Immaturus 5-15 part.
3. pharmaceutical preparation as claimed in claim 2, it is characterized in that, described preparation is prepared by the Chinese medicinal components of following weight portion: Aloe 40 parts, Fructus Cannabis 13 parts, the Radix Aucklandiae 8 parts, Fructus Mume 7 parts, Semen Cassiae 14 parts, 10 parts of Colla Corii Asini, the Rhizoma Atractylodis Macrocephalae 11 parts, 9 parts of Radix Glycyrrhizae, Rhizoma Dioscoreae 35 parts, Herba Aristolochiae 6 parts, Radix Trichosanthis 12 parts, Coriolous Dersicolor (Fr.) Quel 14 parts, Fructus Chaenomelis 11 parts, Fructus Terminaliae Billericae 7 parts, Mel 18 parts, Radix Codonopsis 17 parts, the Radix Astragali 15 parts and Fructus Aurantii Immaturus 10 parts.
4. pharmaceutical preparation as claimed in claim 2, it is characterized in that, described preparation is prepared by the Chinese medicinal components of following weight portion: Aloe 37 parts, Fructus Cannabis 11 parts, the Radix Aucklandiae 7 parts, Fructus Mume 7 parts, Semen Cassiae 15 parts, 10 parts of Colla Corii Asini, the Rhizoma Atractylodis Macrocephalae 10 parts, 8 parts of Radix Glycyrrhizae, Rhizoma Dioscoreae 38 parts, Herba Aristolochiae 6 parts, Radix Trichosanthis 12 parts, Coriolous Dersicolor (Fr.) Quel 14 parts, Fructus Chaenomelis 11 parts, Fructus Terminaliae Billericae 7 parts, Mel 17 parts, Radix Codonopsis 17 parts, the Radix Astragali 15 parts and Fructus Aurantii Immaturus 10 parts.
5. pharmaceutical preparation as claimed in claim 2, it is characterised in that described preparation can be the pharmaceutically acceptable dosage forms such as capsule, oral administration solution, tablet.
6. preparing the drug formulation process described in claim 1 or 2, it comprises the steps:
(1) corresponding raw material components is weighed according to weight standby;
(2) Colla Corii Asini, Radix Codonopsis, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae and Radix Glycyrrhizae wear into fine powder, cross 80-100 order and shine, standby;
(3) Semen Cassiae, Herba Aristolochiae, Radix Trichosanthis, Coriolous Dersicolor (Fr.) Quel, Fructus Cannabis, Fructus Terminaliae Billericae and Radix Aucklandiae employing alcohol extracting method, 75% ethanol backwash 1-3 time, each 1-3 hour, medicinal liquid filters, reclaims ethanol, 60-80 DEG C, it is evaporated to the extractum that relative density is 1.05, standby;
(4) by Aloe, Fructus Mume, Rhizoma Dioscoreae, Fructus Aurantii Immaturus, Fructus Chaenomelis and Mel, add the pure water of 6-12 times of volume, decoct secondary, 1.5 hours first times, second time 0.5 hour, collecting decoction, filter, be evaporated to the extractum that relative density is 1.10, standby;
(5) extractum in step (3) and step (4) is taken, add the fine powder of step (2), measure its weight, add the sucrose of its weight 10-30% and the mixture of dextrin, stir heating to 80��90 DEG C, cross 80 mesh sieves, prepare extract powder with spray dryer, load capsule.
7. the method for preparation pharmaceutical preparation according to claim 5, it is characterised in that: sucrose and dextrin weight ratio described in step (5) are 1:1; Described capsule weight 0.5-1g.
8. preparing the drug formulation process described in claim 1 or 2, it comprises the steps:
(1) by Aloe, Fructus Cannabis, the Radix Aucklandiae, Fructus Mume, Semen Cassiae, Colla Corii Asini, the Rhizoma Atractylodis Macrocephalae, Radix Glycyrrhizae, Rhizoma Dioscoreae, Herba Aristolochiae, Radix Trichosanthis, Coriolous Dersicolor (Fr.) Quel, Fructus Chaenomelis, Fructus Terminaliae Billericae, Mel, Radix Codonopsis, the Radix Astragali and Fructus Aurantii Immaturus, add the pure water of 8-12 times of volume, decoct secondary, 1.5 hours first times, second time 0.5 hour, collecting decoction, filters, is evaporated to the extractum that relative density is 1.10, dry, grind, after crossing 80 mesh sieves, obtain fine powder, standby;
(2) by the fine powder of step (1) and lactose, microcrystalline Cellulose mix homogeneously, with 50% ethanol soft material, cross 20 mesh sieves to granulate, forced air drying under 60 DEG C of conditions, 20 mesh sieve granulate, it is subsequently adding sodium carboxymethyl cellulose and the magnesium stearate mix homogeneously tabletting of recipe quantity, altogether system 1000.
9. preparing the drug formulation process described in claim 1 or 2, it comprises the steps:
(1) by Aloe, Fructus Cannabis, the Radix Aucklandiae, Fructus Mume, Semen Cassiae, Colla Corii Asini, the Rhizoma Atractylodis Macrocephalae, Radix Glycyrrhizae, Rhizoma Dioscoreae, Herba Aristolochiae, Radix Trichosanthis, Coriolous Dersicolor (Fr.) Quel, Fructus Chaenomelis, Fructus Terminaliae Billericae, Mel, Radix Codonopsis, the Radix Astragali and Fructus Aurantii Immaturus, add the pure water of 8-12 times of volume, decoct secondary, 1.5 hours first times, second time 0.5 hour, collecting decoction, filters, is evaporated to the extractum that relative density is 1.10, dry, grind, after crossing 80 mesh sieves, obtain fine powder, standby;
(2) fine powder of step (1) is dissolved in the purified water of 1000ml, purified water is added to preparing total amount after adding 150 grams of sucrose of preparation and 2 grams of sodium benzoate stirring and dissolving, filter to the qualified rear fill of clarity 100, specification is that 10ml/ props up, 100 DEG C of flowing steam sterilizations 60 minutes, pack and get final product.
10. pharmaceutical preparation according to claim 1 and 2, it is characterised in that: described preparation purposes in preparing functional constipation medicine.
CN201610035106.4A 2016-01-19 2016-01-19 Medicinal preparation for treating constipation and application and preparing method of medicinal preparation Withdrawn CN105641344A (en)

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107582795A (en) * 2017-08-15 2018-01-16 孟广千 For rushing down the health food of large intestine
CN109619140A (en) * 2019-02-02 2019-04-16 祁连播森农牧科技开发有限公司 A kind of organic nutrition cookies and preparation method thereof containing butter
CN113181292A (en) * 2021-05-20 2021-07-30 南京正宽医药科技有限公司 Traditional Chinese medicine composition for treating constipation

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Publication number Priority date Publication date Assignee Title
CN105213738A (en) * 2015-11-11 2016-01-06 青岛麦瑞特医药技术有限公司 A kind of Chinese medicine being used for the treatment of infantile constipation and preparation method thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105213738A (en) * 2015-11-11 2016-01-06 青岛麦瑞特医药技术有限公司 A kind of Chinese medicine being used for the treatment of infantile constipation and preparation method thereof

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107582795A (en) * 2017-08-15 2018-01-16 孟广千 For rushing down the health food of large intestine
CN109619140A (en) * 2019-02-02 2019-04-16 祁连播森农牧科技开发有限公司 A kind of organic nutrition cookies and preparation method thereof containing butter
CN113181292A (en) * 2021-05-20 2021-07-30 南京正宽医药科技有限公司 Traditional Chinese medicine composition for treating constipation

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Application publication date: 20160608