CN105106438A - Traditional Chinese medicine composition for treating arrhythmia and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating arrhythmia and preparation method thereof Download PDFInfo
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Abstract
The invention relates to the field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for treating arrhythmia and a preparation method thereof. The traditional Chinese medicine composition comprises the following components: aquilaria agallocha, radix codonopsis, herba ephedrae, glycyrrhiza glabra, paris polyphylla, rhizoma corydalis, storax, radix glehniae, schisandra chinensis, bear gall, black sesame seeds, crataegus pinnatifida, rubia cordifolia, poria cocos, peppermint, Chinese wolfberries, herba leonuri, herba pyrolae and semen ziziphi spinosae. The traditional Chinese medicine composition prepared by adopting the preparation method can be used for treating arrhythmia, has the advantages of being good in curative effect, low in cost, high in cure rate, little in limitation and free of adverse drug reaction when being compared with the prior art; by utilizing the synergistic and resisting effects among the traditional Chinese medicinal materials, the medicine composition improves the therapeutic effect, reduces adverse drug reaction, treats both symptoms and root causes of arrhythmia, and besides, the medicine composition has the characteristics of being rigorous in compatibility of medicines, quite mild in the drug property and remarkable in the curative effect, can treat both manifestation and root causes of diseases, and is easy to clinically popularize and utilize in large areas.
Description
Technical field
The invention belongs to technical field of traditional Chinese pharmacology, be specifically related to one and treat ARR Chinese medicine composition and preparation method thereof.
Background technology
Arrhythmia is because the exciting exception of sinuatrial node or excitement result from beyond sinuatrial node; exciting conduction slowly, retardance or through abnormal passage conduction, namely the origin of cardiomotility and (or) conductive impairment cause frequency and (or) the allorhythmia of heartbeat.Arrhythmia is one group of disease important in cardiovascular disease.It can be fallen ill separately and also can occur together with cardiovascular diseases.Can break out and cause sudden death, also sustainablely involve heart and cause its exhaustion.
Arrhythmia is found in various organic heart disease, wherein with coronary atherosclerotic heart disease (abbreviation coronary heart disease), cardiomyopathy, myocarditis and rheumatic heart disease (abbreviation rheumatic heart disease) are for common, especially when there is heart failure or acute myocardial infarction, occur in that arrhythmia in basic healthy person or autonomic nervous dysfunction patient is quite a few sees, other causes of disease still have electrolyte or endocrine disturbance, anesthesia, low temperature, thoracic cavity or operation on heart, drug effect and central nervous system disease etc., part etiology unknown.
The clinical manifestation of ARR hemodynamic responses depends primarily on ARR character, type, cardiac function and the degree to hemodynamic effects, as slight sinus bradycardia, arrhythmia, accidental atrial premature beat, first degree A-V blocks etc. are very little to hemodynamic effects, therefore without obvious clinical manifestation, more serious arrhythmia, as sick sinus syndrome, rapid atrial fibrillation, paroxysmal supraventricular tachycardia, sustained ventricular tachycardia etc., cardiopalmus can be caused, breast is vexed, dizzy, hypotension, perspire, fainting can appear in severe patient, Adams Stokes syndrome, even die suddenly, because ARR type is different, clinical manifestation is different.
Although the ARR medicine of western medicine is many, but the effective dose of many Drug therapys is very close with the dosage causing toxicity, dosage is with losing control of arrhythmia not, more serious arrhythmia is likely caused again with sufficient dosage, sometimes the improvement of symptom is also unsatisfactory, even increase the mortality rate of cardiovascular diseases, the ARR advantage for the treatment of by Chinese herbs is Integrate adjustment, can multipath, too many levels, Mutiple Targets block arrhythmia occur.Therefore, develop a kind of effective Chinese drugs agentia improving arrhythmia symptom to seem particular importance
Summary of the invention
In order to overcome deficiency of the prior art, the invention provides one and treating ARR Chinese medicine composition and preparation method thereof, there is significant curative effect.
In order to solve the problems of the technologies described above, the technical solution used in the present invention is as follows: one treats ARR Chinese medicine composition, is made up of following component: Lignum Aquilariae Resinatum, Radix Codonopsis, Herba Ephedrae, Radix Glycyrrhizae, Rhizoma Paridis, salt Rhizoma Corydalis, Su Hexiang, Radix Glehniae, Fructus Schisandrae Chinensis, Fel Ursi, Semen Sesami Nigrum, Fructus Crataegi, Radix Rubiae, Poria, Herba Menthae, Fructus Lycii, Herba Leonuri, Herba Pyrolae, Semen Ziziphi Spinosae, Radix Sophorae Tonkinensis, Fructus Arctii, the Radix Astragali.
As preferably, the present invention is made up of each component of following parts by weight:
Lignum Aquilariae Resinatum 1-30 part, Radix Codonopsis 1-30 part, Herba Ephedrae 1-30 part, Radix Glycyrrhizae 1-30 part, Rhizoma Paridis 1-30 part, salt Rhizoma Corydalis 1-30 part, Soviet Union and fragrant 1-30 part, Radix Glehniae 1-30 part, Fructus Schisandrae Chinensis 1-30 part, Fel Ursi 1-30 part, Semen Sesami Nigrum 1-30 part, Fructus Crataegi 1-30 part, Radix Rubiae 1-30 part, Poria 1-30 part, Herba Menthae 1-30 part, Fructus Lycii 1-30 part, Herba Leonuri 1-30 part, Herba Pyrolae 1-30 part, Semen Ziziphi Spinosae 1-30 part, Radix Sophorae Tonkinensis 1-30 part, Fructus Arctii 1-30 part, Radix Astragali 1-30 part.
As preferably, the present invention is made up of each component of following parts by weight:
Lignum Aquilariae Resinatum 1-15 part, Radix Codonopsis 1-15 part, Herba Ephedrae 1-15 part, Radix Glycyrrhizae 1-15 part, Rhizoma Paridis 1-15 part, salt Rhizoma Corydalis 1-15 part, Soviet Union and fragrant 1-15 part, Radix Glehniae 1-15 part, Fructus Schisandrae Chinensis 1-15 part, Fel Ursi 1-15 part, Semen Sesami Nigrum 1-15 part, Fructus Crataegi 1-15 part, Radix Rubiae 1-15 part, Poria 1-15 part, Herba Menthae 1-15 part, Fructus Lycii 1-15 part, Herba Leonuri 1-15 part, Herba Pyrolae 1-15 part, Semen Ziziphi Spinosae 1-15 part, Radix Sophorae Tonkinensis 1-15 part, Fructus Arctii 1-15 part, Radix Astragali 1-15 part.
As preferably, the present invention also comprises following parts by weight component: Herba Taraxaci 1-15 part, Radix Isatidis 1-15 part, Semen Ginkgo 1-15 part.
As preferably, the present invention also comprises following parts by weight component: Semen Sterculiae Lychnophorae 1-15 part, Aloe 1-15 part, Folium Sennae 1-15 part.
As preferably, the dosage form of Chinese medicine preparation of the present invention is: sublimed preparation, powder, injection, plaster, syrup, oral liquid, suck agent, granule, sugar coated tablet, film coated tablet, capsule.
As preferably, the preparation of Chinese medicine of the present invention comprises the following steps:
(1) Herba Ephedrae, Rhizoma Paridis, salt Rhizoma Corydalis, Fructus Schisandrae Chinensis, Radix Rubiae, Herba Pyrolae, Radix Sophorae Tonkinensis, Fructus Arctii, the Radix Astragali, Semen Sterculiae Lychnophorae, Folium Sennae, Herba Taraxaci, Radix Isatidis, Semen Ginkgo raw material is got by medicine: the Capacity Ratio of water is 1: 2 ~ 10 soak at least 1 hour, add suitable quantity of water again to decoct 1 ~ 5 hour, elimination medicinal residues, under the condition of negative pressure, low temperature, the Chinese medicine leaching liquid of clarification being concentrated into Bomi degree is more than 80%, dry powder (temperature≤100 DEG C of spout) is made by powder spraying apparatus, for subsequent use;
(2) get Radix Codonopsis, ethanol that Radix Glehniae, Fructus Lycii, Herba Menthae, Poria, Aloe, Su Hexiang, Lignum Aquilariae Resinatum add 1-5 times amount, at 60-100 DEG C of alcoholization 50-120 minute, add the water of 1-5 times amount again, at 80 DEG C of insulation 50-120 minute, concentration and recovery ethanol, obtain mixed liquor, filter mixed liquor obtains filtrate, and the Chinese medicine residue of filtration repeats above extraction step; Merge twice filtrate, with aperture at 1000um, molecular cut off is in the high temperature resistant high rejection rolling NF membrane of 200KDalton, isolate the large particulate matter in filtrate and supernatant, supernatant concentration, at simmer down to 60 DEG C, relative density is the thick paste of 1.10 ~ 1.14, for subsequent use.
(3) get Fel Ursi, Herba Leonuri, Fructus Crataegi, Semen Sesami Nigrum, Semen Ziziphi Spinosae, Radix Glycyrrhizae pulverize and sieve, cross 200 mesh sieves, obtain drug powder.
(4) by above-mentioned steps (1), (2) and (3) mix homogeneously, gained mixture and described excipient substance are made required corresponding dosage form.
As preferably, the present invention, when described pharmaceutical dosage form is capsule, comprises the following steps:
(1) Herba Ephedrae, Rhizoma Paridis, salt Rhizoma Corydalis, Fructus Schisandrae Chinensis, Radix Rubiae, Herba Pyrolae, Radix Sophorae Tonkinensis, Fructus Arctii, the Radix Astragali, Semen Sterculiae Lychnophorae, Folium Sennae, Herba Taraxaci, Radix Isatidis, Semen Ginkgo raw material is got by medicine: the Capacity Ratio of water is 1: 2 ~ 10 soak at least 1 hour, add suitable quantity of water again to decoct 1 ~ 5 hour, elimination medicinal residues, under the condition of negative pressure, low temperature, the Chinese medicine leaching liquid of clarification being concentrated into Bomi degree is more than 80%, dry powder (temperature≤100 DEG C of spout) is made by powder spraying apparatus, for subsequent use;
(2) get Radix Codonopsis, ethanol that Radix Glehniae, Fructus Lycii, Herba Menthae, Poria, Aloe, Su Hexiang, Lignum Aquilariae Resinatum add 1-5 times amount, at 60-100 DEG C of alcoholization 50-120 minute, add the water of 1-5 times amount again, at 80 DEG C of insulation 50-120 minute, concentration and recovery ethanol, obtain mixed liquor, filter mixed liquor obtains filtrate, and the Chinese medicine residue of filtration repeats above extraction step; Merge twice filtrate, with aperture at 1000um, molecular cut off is in the high temperature resistant high rejection rolling NF membrane of 200KDalton, isolate the large particulate matter in filtrate and supernatant, supernatant concentration, at simmer down to 60 DEG C, relative density is the thick paste of 1.10 ~ 1.14, for subsequent use.
(3) get Fel Ursi, Herba Leonuri, Fructus Crataegi, Semen Sesami Nigrum, Semen Ziziphi Spinosae, Radix Glycyrrhizae pulverize and sieve, cross 200 mesh sieves, obtain drug powder.
(4) by above-mentioned steps (1), (2), (3) gained mix homogeneously, pulverize dry mixture, mixture is added capsule adjuvant, through granulating, drying and granulate obtain capsule particle, eventually pass that capsule is canned obtains capsule.
Theoretical foundation of the present invention:
Lignum Aquilariae Resinatum: nature and flavor: acrid in the mouth, hardship, slightly warm in nature.Gui Jing: return spleen, stomach, kidney channel.Effect: promoting the circulation of QI to relieve pain, warming middle-JIAO to arrest vomiting, helping inspiration to relieve asthma.Cure mainly: for the vexed pain of breast abdominal distention, gastrofrigid vomiting singultus, QI rising in reverse order of suffering from a deficiency of the kidney dyspnea with rapid respiration.
Radix Codonopsis: sweet in the mouth, property is put down.Have invigorating the spleen and replenishing QI, quench the thirst, spleen invigorating lung benefiting, nourishing blood to promote the production of body fluid.For deficiency of both the splenic and pulmonary QI, lack of appetite asthenia, cough dyspnea due to deficiency, insufficiency of vital energy and blood, shallow complexion, shortness of breath and palpitation, Tianjin wound is thirsty, and interior-heat is quenched one's thirst.Lazy speech is losed heart, myasthenia of limbs, be off one's feed, the deficiency of vital energy, gas Tianjin two are empty, QI and blood is two loses and the disease such as blood deficiency and yellow complexion.But exterior syndrome is not separated and can not the using of the fullness in the epigastrium and abdomen domination of pathogen.This product effect is similar to Radix Ginseng, and only the efficacy of a drug is weak.Control general deficiency syndrome, Radix Ginseng can be replaced to use; Collapse is heavily demonstrate,proved, then be still advisable with Radix Ginseng.Autumn excavates, and cleans, dries.
Herba Ephedrae: nature and flavor: pungent, micro-hardship, temperature.Gui Jing: return lung, urinary bladder channel.Function cures mainly: diaphoresis cold expelling, depressed lung-energy dispersing, inducing diuresis to remove edema.For anemofrigid cold, uncomfortable in chestly to breath with cough, edema due to wind pathogen edema; Bronchial asthma.Herba ephedrae nourishing the lung to arrest cough.Be used for table disease to separate, asthma and cough.
Radix Glycyrrhizae: nature and flavor: sweet, flat.Gui Jing: GUIXIN, lung, spleen, stomach warp.Function cures mainly: invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.
Rhizoma Paridis: nature and flavor: bitter, cold.Slightly poisonous.Function cures mainly: heat-clearing and toxic substances removing, reducing swelling and alleviating pain.Epidemic encephalitis type B, stomachache, appendicitis, tuberculous lymphadenitis, tonsillitis, parotitis, mastitis, poisonous snake, insect-bite, sore swollen toxin.
Salt Rhizoma Corydalis: nature and flavor: arduous, temperature.1. " Haiyao Bencao, Oversea Materia Medica ": " bitter but sweet flavor is nontoxic." 2. " Kaibao Bencao ": " acrid in the mouth, temperature, nontoxic." return through: enter liver, stomach warp.1. Materia Medica of Decoction: " meridian of Foot-TAI YIN of starting with." 2. " book on Chinese herbal medicine covers bamboo fish trap ": " enters lunar spleen, lung, and a cloud walks Liver Channel again." 3. " Thunder God concocts property of medicine solution ": " enters the heart, lung, spleen, stomach four warp." function cures mainly: invigorate blood circulation, and dissipating blood stasis is regulated the flow of vital energy, pain relieving.Control all pains of trusted subordinate's waist knee joint, menoxenia, lump in the abdomen, metrorrhagia, puerperal blood faints, lochiorrhea, traumatic injury.
Soviet Union and perfume: nature and flavor: pungent, temperature.1. " not Lu ": " sweet in the mouth, temperature, nontoxic." 2. " book on Chinese herbal medicine just ": " sweet in the mouth is pungent, warm in nature." return through: enter lung, Liver Channel.1. " beautiful Chinese catalpa medicine solution ": " start with lunar lung, liver channel of foot-Jueyin." 2. " must join book on Chinese herbal medicine ": " enters meridian of Foot-TAI YIN." 3. " book on Chinese herbal medicine is new again ": " enters spleen, stomach two warp." function cures mainly: sensible, wards off dirty, dissipating depression of QI, eliminating phlegm.Control soldier so to faint, expectorant heap soil or fertilizer over and around the roots is lost consciousness, infantile convulsion, pyrexial malaria, the sudden pain of trusted subordinate, scabies, chilblain.
Radix Glehniae: nature and flavor: sweetness and bitterness is light is cool.Cold nature, sweet in the mouth, micro-hardship.1. " herbal classic is met former ": sweet light, cold in nature, nontoxic.2. " Bencao Congxin ": sweetness and bitterness is lightly seasoned, is slightly cold.Gui Jing: enter lung, spleen channel.1. " book on Chinese herbal medicine must be joined ": enter meridian of Hand-TAI YIN.2. " book on Chinese herbal medicine brief points ": to start with, meridian of Foot-TAI YIN.Function cures mainly: nourishing YIN and clearing away lung-heat, expelling phlegm for arresting cough.Control lung-heat type cough, chronic consumptive disease chronic cough, the moon hinders dry pharynx, thirsty.
Fructus Schisandrae Chinensis: nature and flavor: sour, sweet, temperature.Gui Jing: return lung, the heart, kidney channel.Function cures mainly: restrain astringent or styptic treatment for spontaneous sweating, supplementing QI for promoting the production of body fluid, kidney calming.For chronic cough dyspnea due to deficiency, emission, enuresis frequent micturition, incessant chronic diarrhea, spontaneous perspiration, night sweat, Tianjin wound is thirsty, and deficient pulse of losing heart, interior-heat is quenched one's thirst, palpitation and insomnia.
Fel Ursi: bitter in the mouth, cold in nature.There is effect of heat-clearing and toxic substances removing, spasmolytic, analgesia, calmness, improving eyesight, liver heat removing, lung moistening, parasite killing.Control the diseases such as pediatric epilepsy scared, infantile malnutrition, conjunctival congestion and swelling pain, cataracta, sore throat, jaundice, cholelithiasis colic, stomachache, dysentery, sore and toxic, hemorrhoid.
Semen Sesami Nigrum: sweet in the mouth, property is put down.There is nourishing the liver and kidney, beneficial blood intestine moistening, relieving constipation, the function of lactogenesis.
Fructus Crataegi: nature and flavor: acid is sweet, tepor.Gui Jing: enter spleen, stomach, Liver Channel.Function cures mainly: help digestion long-pending, dissipating blood stasis blood, expelling tenia.Control meat to amass, lump in the abdomen, phlegm retention, feeling of fullness, acid regurgitation, dysentery, hemorrhoidal hamorrhage, lumbago, hernia after-pains in puerperal, lochiorrhea, children's's breast food is stagnated.Promoting digestion and invigorating the stomach, circulation of qi promoting dissipating blood stasis.For meat stagnation, stomach alkane distension, dysentery stomachache, blood stasis amenorrhea, postpartum stagnation, trusted subordinate's twinge, hernia pain, hyperlipidemia.
Radix Rubiae: removing heat from blood and promoting blood circulation, blood stasis dispelling, stimulates the menstrual flow.For haematemesis, epistaxis, metrostaxis, traumatic hemorrhage, amenorrhea stasis blocking, arthralgia, tumbling and swelling.Cooling blood for hemostasis, blood circulation promoting and blood stasis dispelling: this product is stopped blooding and do not stay the stasis of blood, amenorrhea stomachache, traumatic injury hemorrhage for heat syndrome.Join Os Sepiae hemostasis power stronger.
Poria: nature and flavor: sweet, light is flat.Gui Jing: GUIXIN, lung, spleen, kidney channel.Function cures mainly: promoting diuresis to eliminate damp pathogen, spleen invigorating mind calming.For edema oliguria, phlegm retention vertigo and palpitation, insufficiency of the spleen lack of appetite, have loose bowels in loose stool, irritability, palpitation with fear insomnia.
Herba Menthae: nature and flavor: pungent is cool.Gui Jing: return lung, Liver Channel.Function cures mainly: dispelling wind-heat.Refresh oneself, rash.For anemopyretic cold, pathogenic wind-warm from the beginning of, headache, conjunctival congestion, sore throat, aphtha, rubella, measles, breast the side of body feeling of distension and oppression.
Fructus Lycii: nature and flavor: sweet, flat.Gui Jing: return liver, kidney channel.Function cures mainly: nourishing the liver and kidney, replenishing vital essence to improve eyesight.For asthenia damage of essence, soreness of waist and knee joint, vertigo and tinnitus, interior-heat is quenched one's thirst, blood deficiency and yellow complexion, and blurred vision is failed to understand.
Herba Leonuri: nature and flavor: bitter, pungent, is slightly cold.Gui Jing: return liver, pericardium channel.Function cures mainly: promoting blood flow to regulate menstruation, inducing diuresis to remove edema.For menoxenia, dysmenorrhea, amenorrhea, lochiorrhea, edema oliguria; Acute nephritis edema.
Herba Pyrolae: nature and flavor: sweet, bitter, temperature.Gui Jing: return liver, kidney channel.Function cures mainly: wind-damp dispelling, bone and muscle strengthening, hemostasis.For rheumatic arthralgia, weakness of the waist and knees, menorrhagia, chronic cough due to asthenia of viscera.
Semen Ziziphi Spinosae: nature and flavor: sweet, sour is flat.Gui Jing: return liver, gallbladder, heart channel.Function cures mainly: tonifying liver, mind calming, and arresting sweating promotes the production of body fluid.For restlessness of asrhenia type and insomnia, palpitation with fear dreaminess, the empty hyperhidrosis of body, Tianjin wound is thirsty.
Radix Sophorae Tonkinensis: nature and flavor: bitter, cold; Poisonous.Gui Jing: attach to the lung and stomach meridians.Function cures mainly: heat-clearing and toxic substances removing, detumescence sore-throat relieving.Pent up for fire-toxin, laryngopharynx swelling and pain, gingivitis.
Fructus Arctii: nature and flavor: pungent, bitter, cold.Gui Jing: attach to the lung and stomach meridians.Function cures mainly: dispelling wind and heat pathogens, lung qi dispersing rash, resolving toxin and disinhibiting the throat.For anemopyretic cold, cough with copious phlegm, measles, rubella, laryngopharynx swelling and pain, mumps erysipelas, carbuncle sore tumefacting virus.
The Radix Astragali: nature and flavor: sweet, temperature.Gui Jing: return lung, spleen channel.Function cures mainly: invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, expelling pus and promoting granulation.Weak for the deficiency of vital energy, anorexia and loose stool, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, deficiency of vital energy edema, carbuncle difficulty is burst, and burst for a long time and do not hold back, blood deficiency dull yellowish colored skin, interior-heat is quenched one's thirst; Chronic nephritis proteinuria, diabetes.
Semen Sterculiae Lychnophorae: nature and flavor: sweet, cold.Gui Jing: return lung, large intestine channel.Function cures mainly: clearing heat and moistening lung, liyan jiedu, loosening bowel to relieve constipation.For lung-heat celostomia, dry cough without phlegm, pharyngodynia with dryness, accumulation of heat just closes, headache conjunctival congestion.
Aloe: nature and flavor: bitter, cold.Gui Jing: return liver, stomach, large intestine channel.Function cures mainly: removing heat from the liver, relieving constipation.For constipation, infantile malnutrition, infantile convulsion; External treatment exudative dermatitis.
Folium Sennae: nature and flavor: sweet, bitter, cold.Gui Jing: return large intestine channel.Function cures mainly: the row that purges heat is stagnant, relieving constipation, diuretic.Stagnate for accumulation of heat, constipation is suffered from abdominal pain, edema distension.
Herba Taraxaci: nature and flavor: bitter, sweet, cold.Gui Jing: return liver, stomach warp.Function cures mainly: heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, inducing diuresis for treating stranguria syndrome.For furuncle swelling toxin, acute mastitis, scrofula, conjunctival congestion, pharyngalgia, lung abscess, acute appendicitis, jaundice due to damp-heat, the puckery pain of pyretic stranguria.
Radix Isatidis: nature and flavor: bitter, cold.Gui Jing: GUIXIN, stomach warp.Function cures mainly: heat-clearing and toxic substances removing, removing heat from blood sore-throat relieving.For maculae caused by violent heat pathogen, crimson tongue is purple dark, mumps, sore throat, scarlet fever, major part pestilence, erysipelas, carbuncle.
Semen Ginkgo: nature and flavor: sweet, bitter, puckery, flat; Poisonous.Gui Jing: return lung meridian.Function cures mainly: astringing lung QI for relieving asthma, and leukorrhagia stopping is turbid, urine reducing.Breath with cough for abundant expectoration, leukorrhagia nebulousurine, enuresis frequent micturition.
Herba Taraxaci: nature and flavor: bitter, sweet, cold.Gui Jing: return liver, stomach warp.Function cures mainly: heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, inducing diuresis for treating stranguria syndrome.For furuncle swelling toxin, acute mastitis, scrofula, conjunctival congestion, pharyngalgia, lung abscess, acute appendicitis, jaundice due to damp-heat, the puckery pain of pyretic stranguria.
Radix Isatidis: nature and flavor: bitter, cold.Gui Jing: GUIXIN, stomach warp.Function cures mainly: heat-clearing and toxic substances removing, removing heat from blood sore-throat relieving.For maculae caused by violent heat pathogen, crimson tongue is purple dark, mumps, sore throat, scarlet fever, major part pestilence, erysipelas, carbuncle.
Semen Ginkgo: nature and flavor: sweet, bitter, puckery, flat; Poisonous.Gui Jing: return lung meridian.Function cures mainly: astringing lung QI for relieving asthma, and leukorrhagia stopping is turbid, urine reducing.Breath with cough for abundant expectoration, leukorrhagia nebulousurine, enuresis frequent micturition.
Semen Sterculiae Lychnophorae: nature and flavor: sweet, cold.Gui Jing: return lung, large intestine channel.Function cures mainly: clearing heat and moistening lung, liyan jiedu, loosening bowel to relieve constipation.For lung-heat celostomia, dry cough without phlegm, pharyngodynia with dryness, accumulation of heat just closes, headache conjunctival congestion.
Aloe: nature and flavor: bitter, cold.Gui Jing: return liver, stomach, large intestine channel.Function cures mainly: removing heat from the liver, relieving constipation.For constipation, infantile malnutrition, infantile convulsion; External treatment exudative dermatitis.
Folium Sennae: nature and flavor: sweet, bitter, cold.Gui Jing: return large intestine channel.Function cures mainly: the row that purges heat is stagnant, relieving constipation, diuretic.Stagnate for accumulation of heat, constipation is suffered from abdominal pain, edema distension.
In sum, medicine of the present invention is used for the treatment of arrhythmia, advantages such as relative to prior art, there is good effect, cost is low, cure rate is high, limitation is little, have no adverse reaction, collaborative or the resistant function that the present invention utilizes Chinese medicine mutual, improve therapeutic effect, decrease untoward reaction, treating both the principal and secondary aspects of a disease.It is rigorous that medicine of the present invention has compatibility, mild in medicine property and, feature evident in efficacy, treating both the principal and secondary aspects of a disease, is convenient to large scale application clinically.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is further elaborated.
Embodiment 1
The raw material composition of effective ingredient of the present invention and parts by weight are: Lignum Aquilariae Resinatum 1 part, Radix Codonopsis 1 part, 1 part, Herba Ephedrae, 3 parts, Radix Glycyrrhizae, Rhizoma Paridis 2 parts, salt Rhizoma Corydalis 1 part, Soviet Union and fragrant 1 part, Radix Glehniae 1 part, Fructus Schisandrae Chinensis 2 parts, Fel Ursi 1 part, Semen Sesami Nigrum 5 parts, Fructus Crataegi 2 parts, 1 part, Radix Rubiae, 2 parts, Poria, Herba Menthae 1 part, Fructus Lycii 1 part, Herba Leonuri 2 parts, Herba Pyrolae 1 part, Semen Ziziphi Spinosae 2 parts, Radix Sophorae Tonkinensis 2 parts, Fructus Arctii 1 part, the Radix Astragali 2 parts.
When described pharmaceutical dosage form is capsule, comprise the following steps:
(1) Herba Ephedrae, Rhizoma Paridis, salt Rhizoma Corydalis, Fructus Schisandrae Chinensis, Radix Rubiae, Herba Pyrolae, Radix Sophorae Tonkinensis, Fructus Arctii, Astragalus membranaceus raw material is got by medicine: the Capacity Ratio of water is 1: 2 ~ 10 soak at least 1 hour, add suitable quantity of water again to decoct 1 ~ 5 hour, elimination medicinal residues, under the condition of negative pressure, low temperature, the Chinese medicine leaching liquid of clarification being concentrated into Bomi degree is more than 80%, dry powder (temperature≤100 DEG C of spout) is made by powder spraying apparatus, for subsequent use;
(2) get Radix Codonopsis, ethanol that Radix Glehniae, Fructus Lycii, Herba Menthae, Poria, Su Hexiang, Lignum Aquilariae Resinatum add 1-5 times amount, at 60-100 DEG C of alcoholization 50-120 minute, add the water of 1-5 times amount again, at 80 DEG C of insulation 50-120 minute, concentration and recovery ethanol, obtain mixed liquor, filter mixed liquor obtains filtrate, and the Chinese medicine residue of filtration repeats above extraction step; Merge twice filtrate, with aperture at 1000um, molecular cut off is in the high temperature resistant high rejection rolling NF membrane of 200KDalton, isolate the large particulate matter in filtrate and supernatant, supernatant concentration, at simmer down to 60 DEG C, relative density is the thick paste of 1.10 ~ 1.14, for subsequent use.
(3) get Fel Ursi, Herba Leonuri, Fructus Crataegi, Semen Sesami Nigrum, Semen Ziziphi Spinosae, Radix Glycyrrhizae pulverize and sieve, cross 200 mesh sieves, obtain drug powder.
(4) by above-mentioned steps (1), (2), (3) gained mix homogeneously, pulverize dry mixture, mixture is added capsule adjuvant, through granulating, drying and granulate obtain capsule particle, eventually pass that capsule is canned obtains capsule.
Embodiment 2
The raw material composition of effective ingredient of the present invention and parts by weight are: Lignum Aquilariae Resinatum 1 part, Radix Codonopsis 1 part, 1 part, Herba Ephedrae, 3 parts, Radix Glycyrrhizae, Rhizoma Paridis 2 parts, salt Rhizoma Corydalis 1 part, Soviet Union and fragrant 1 part, Radix Glehniae 1 part, Fructus Schisandrae Chinensis 2 parts, Fel Ursi 1 part, Semen Sesami Nigrum 5 parts, Fructus Crataegi 2 parts, 1 part, Radix Rubiae, 2 parts, Poria, Herba Menthae 1 part, Fructus Lycii 1 part, Herba Leonuri 2 parts, Herba Pyrolae 1 part, Semen Ziziphi Spinosae 2 parts, Radix Sophorae Tonkinensis 2 parts, Fructus Arctii 1 part, the Radix Astragali 2 parts, Herba Taraxaci 2 parts, Radix Isatidis 2 parts, Semen Ginkgo 1 part,
When described pharmaceutical dosage form is capsule, comprise the following steps:
(1) Herba Ephedrae, Rhizoma Paridis, salt Rhizoma Corydalis, Fructus Schisandrae Chinensis, Radix Rubiae, Herba Pyrolae, Radix Sophorae Tonkinensis, Fructus Arctii, the Radix Astragali, Herba Taraxaci, Radix Isatidis, Semen Ginkgo raw material is got by medicine: the Capacity Ratio of water is 1: 2 ~ 10 soak at least 1 hour, add suitable quantity of water again to decoct 1 ~ 5 hour, elimination medicinal residues, under the condition of negative pressure, low temperature, the Chinese medicine leaching liquid of clarification being concentrated into Bomi degree is more than 80%, dry powder (temperature≤100 DEG C of spout) is made by powder spraying apparatus, for subsequent use;
(2) get Radix Codonopsis, ethanol that Radix Glehniae, Fructus Lycii, Herba Menthae, Poria, Su Hexiang, Lignum Aquilariae Resinatum add 1-5 times amount, at 60-100 DEG C of alcoholization 50-120 minute, add the water of 1-5 times amount again, at 80 DEG C of insulation 50-120 minute, concentration and recovery ethanol, obtain mixed liquor, filter mixed liquor obtains filtrate, and the Chinese medicine residue of filtration repeats above extraction step; Merge twice filtrate, with aperture at 1000um, molecular cut off is in the high temperature resistant high rejection rolling NF membrane of 200KDalton, isolate the large particulate matter in filtrate and supernatant, supernatant concentration, at simmer down to 60 DEG C, relative density is the thick paste of 1.10 ~ 1.14, for subsequent use.
(3) get Fel Ursi, Herba Leonuri, Fructus Crataegi, Semen Sesami Nigrum, Semen Ziziphi Spinosae, Radix Glycyrrhizae pulverize and sieve, cross 200 mesh sieves, obtain drug powder.
(4) by above-mentioned steps (1), (2), (3) gained mix homogeneously, pulverize dry mixture, mixture is added capsule adjuvant, through granulating, drying and granulate obtain capsule particle, eventually pass that capsule is canned obtains capsule.
Embodiment 3
The raw material composition of effective ingredient of the present invention and parts by weight are: Lignum Aquilariae Resinatum 1 part, Radix Codonopsis 1 part, 1 part, Herba Ephedrae, 3 parts, Radix Glycyrrhizae, Rhizoma Paridis 2 parts, salt Rhizoma Corydalis 1 part, Soviet Union and fragrant 1 part, Radix Glehniae 1 part, Fructus Schisandrae Chinensis 2 parts, Fel Ursi 1 part, Semen Sesami Nigrum 5 parts, Fructus Crataegi 2 parts, 1 part, Radix Rubiae, 2 parts, Poria, Herba Menthae 1 part, Fructus Lycii 1 part, Herba Leonuri 2 parts, Herba Pyrolae 1 part, Semen Ziziphi Spinosae 2 parts, Radix Sophorae Tonkinensis 2 parts, Fructus Arctii 1 part, the Radix Astragali 2 parts, Herba Taraxaci 2 parts, Radix Isatidis 2 parts, Semen Ginkgo 1 part, Semen Sterculiae Lychnophorae 1 part, Aloe 4 parts, Folium Sennae 1 part.
When described pharmaceutical dosage form is capsule, comprise the following steps:
(1) Herba Ephedrae, Rhizoma Paridis, salt Rhizoma Corydalis, Fructus Schisandrae Chinensis, Radix Rubiae, Herba Pyrolae, Radix Sophorae Tonkinensis, Fructus Arctii, the Radix Astragali, Semen Sterculiae Lychnophorae, Folium Sennae, Herba Taraxaci, Radix Isatidis, Semen Ginkgo raw material is got by medicine: the Capacity Ratio of water is 1: 2 ~ 10 soak at least 1 hour, add suitable quantity of water again to decoct 1 ~ 5 hour, elimination medicinal residues, under the condition of negative pressure, low temperature, the Chinese medicine leaching liquid of clarification being concentrated into Bomi degree is more than 80%, dry powder (temperature≤100 DEG C of spout) is made by powder spraying apparatus, for subsequent use;
(2) get Radix Codonopsis, ethanol that Radix Glehniae, Fructus Lycii, Herba Menthae, Poria, Aloe, Su Hexiang, Lignum Aquilariae Resinatum add 1-5 times amount, at 60-100 DEG C of alcoholization 50-120 minute, add the water of 1-5 times amount again, at 80 DEG C of insulation 50-120 minute, concentration and recovery ethanol, obtain mixed liquor, filter mixed liquor obtains filtrate, and the Chinese medicine residue of filtration repeats above extraction step; Merge twice filtrate, with aperture at 1000um, molecular cut off is in the high temperature resistant high rejection rolling NF membrane of 200KDalton, isolate the large particulate matter in filtrate and supernatant, supernatant concentration, at simmer down to 60 DEG C, relative density is the thick paste of 1.10 ~ 1.14, for subsequent use.
(3) get Fel Ursi, Herba Leonuri, Fructus Crataegi, Semen Sesami Nigrum, Semen Ziziphi Spinosae, Radix Glycyrrhizae pulverize and sieve, cross 200 mesh sieves, obtain drug powder.
(4) by above-mentioned steps (1), (2), (3) gained mix homogeneously, pulverize dry mixture, mixture is added capsule adjuvant, through granulating, drying and granulate obtain capsule particle, eventually pass that capsule is canned obtains capsule.
Animal experiment:
1, anthology invention medicine is medicine group, and its Chinese medicine group 1 is made according to embodiment 1, and medicine group 2 is made according to embodiment 2; Matched group selects propafenone; Concentration is all mixed with 30 times that are equivalent to quantity.
2, animal:
Wistar rat 250-300g, male and female dual-purpose.
3, method and result Chinese medicine composition of the present invention are on the impact of Aconitine Induced rat ventricular
Wistar rats divides into groups immediately, continuous gavage 7 days, after last administration 30 minutes, from side jugular vein intubate after 25% urethane 1g/kg intraperitoneal injection of anesthesia, by 1ug/min speed from vein input 0.001% aconitine, record the dosage of each animal generation ventricular premature contraction (VP), ventricular tachycardia (VT) aconitine used respectively, the results are shown in Table 1.
Table 1 Chinese medicine composition of the present invention is on the impact of Aconitine Induced rat ventricular
Result shows, and medicine group 1 of the present invention, medicine group 2 all can significantly improve the consumption of aconitine caused large VP, VT, and medicine group 2 effect is better than medicine group 1.
Chinese medicine composition of the present invention injects the aconitine 20ug of 0.01% to the impact of central nervous system of rats arrhythmia, records each treated animal ARR persistent period, the results are shown in Table 2.
Table 2 Chinese medicine composition of the present invention is on the impact of rat ventricular
| Group | The arrhythmia persistent period (min) |
| Blank | 48.1±19.2 |
| Propafenone | 18.5±10.3 |
| Medicine group 1 | 28.4±9.7 |
| Medicine group 2 | 25.8±11.6 |
Result shows, and medicine group 1 of the present invention, medicine group 2 all obviously can shorten the persistent period of rat ventricular, and the effect of medicine group 2 is better than medicine group 1.
Chinese medicine composition of the present invention brings out the impact of rat ventricular to barium chloride
Rat random packet, continuous gavage 7 days, after last administration 30 minutes, with the chloral hydrate intraperitoneal injection of anesthesia of 6%, lie on the back fixing, record II lead electrocardiogram, injected the barium chloride (8.5ul/s) of 0.5% by femoral vein constant speed, along with the increase of barium chloride dosage, can increased heart rate be occurred, ST section improves, ventricular premature contraction, short battle array ventricular tachycardia, two-way ventricular tachycardia, there is the ARR barium chloride dosage of animal in record, the results are shown in Table 3.
Table 3 Chinese medicine composition of the present invention brings out the impact of rat ventricular on barium chloride.
Result shows, and medicine group 1 of the present invention, medicine group 2 all can make barium chloride bring out rat to occur that the dosage of ventricular premature contraction and two-way ventricular tachycardia obviously increases, and the effect of medicine group 2 is better than medicine group 1.
Clinical trial:
1, Chinese medicine of the present invention was in 2008 to 2015 the routine patients of clinical observation arrhythmia 128, and clinical report is as follows:
2, Therapeutic Method: be divided into four groups, wherein takes the medicine of the embodiment of the present invention 3 for one group, every day 6g, oral meal at twice, 14 days is a course for the treatment of, takes the circumstances into consideration administration according to the state of an illness.Two groups of medicines taking the embodiment of the present invention 1, every day 10g, oral meal at twice, 14 days is a course for the treatment of, takes the circumstances into consideration administration according to the state of an illness.Three groups of medicines taking the embodiment of the present invention 1, every day 8g, oral meal at twice, 14 days is a course for the treatment of, takes the circumstances into consideration administration according to the state of an illness.Take beta-blocker for four groups to treat, strictly take according to explanation.
3, efficacy assessment standard:
Effective: cardiopalmus, tachypnea, uncomfortable in chest, chest pain disappearance, edema, two lung moist rales disappear, without premature beat, and normal ECG.
Effective: cardiopalmus, tachypnea, uncomfortable in chest, chest pain alleviate, two lung moist rales reduce, and premature beat reduces 50%, ECG ST section be comparatively admitted to hospital before recovery >=0.05mV, T ripple shoal and reach 50%.
Invalid: clinical symptoms, sign and electrocardiogram without obviously changing (the Cortex Phellodendri people. cardiovascular diseases's diagnostic criteria [M]. Beijing: Du is published in learning centre, 1991:33.).
4, therapeutic outcome.
| Group | Effective | Effectively | Invalid |
| 1 group | 23 | 9 | 0 |
| 2 groups | 28 | 4 | 0 |
| 3 groups | 29 | 3 | 0 |
| 4 groups | 3 | 4 | 25 |
Model case
1, Zhang, man, 56 years old, the diseases caused by exogenous pathogenic factor a few days, high heat two days, recently had palpitation, breathes hard, has a headache, have a toothache, indigestion and loss of appetite loss of appetite, and time feels sick repeated nauseas, difficulty of falling asleep, dreaminess, red tongue, and yellow fur is thick, and thready pulse sinks unable; After taking 2 courses for the treatment of of Chinese medicine composition of the embodiment of the present invention 3, symptom is obviously improved, and takes 5 recoveries from illness courses for the treatment of.
2, Huang, female, 48 years old, recently, nervous increased frequency, occasionally had outbreak uncomfortable in chest, last for several minutes spontaneous remission; After taking 2 courses for the treatment of of Chinese medicine composition of the embodiment of the present invention 3, symptom is obviously improved, and takes 4 recoveries from illness courses for the treatment of.
3, Zhang, man, 49 years old, sensation was dizzy, hyperhidrosis, occurred comparatively frequent when excited, hammering chest or take a turn for the better to some extent after holding one's breath; After taking 2 courses for the treatment of of Chinese medicine composition of the embodiment of the present invention 3, symptom is obviously improved, and takes 6 recoveries from illness courses for the treatment of.
The above; it is only most preferred embodiment of the present invention; not any pro forma restriction is done to the present invention; any those of ordinary skill in the art; do not departing under technical solution of the present invention ambit; utilize the method content of above-mentioned announcement to make many possible variations and modification to technical solution of the present invention, all belong to the scope of claims protection.
Claims (8)
1. treat an ARR Chinese medicine composition, it is characterized in that: be made up of following component: Lignum Aquilariae Resinatum, Radix Codonopsis, Herba Ephedrae, Radix Glycyrrhizae, Rhizoma Paridis, salt Rhizoma Corydalis, Su Hexiang, Radix Glehniae, Fructus Schisandrae Chinensis, Fel Ursi, Semen Sesami Nigrum, Fructus Crataegi, Radix Rubiae, Poria, Herba Menthae, Fructus Lycii, Herba Leonuri, Herba Pyrolae, Semen Ziziphi Spinosae, Radix Sophorae Tonkinensis, Fructus Arctii, the Radix Astragali.
2. one according to claim 1 treats ARR Chinese medicine composition, it is characterized in that: be made up of each component of following parts by weight:
Lignum Aquilariae Resinatum 1-30 part, Radix Codonopsis 1-30 part, Herba Ephedrae 1-30 part, Radix Glycyrrhizae 1-30 part, Rhizoma Paridis 1-30 part, salt Rhizoma Corydalis 1-30 part, Soviet Union and fragrant 1-30 part, Radix Glehniae 1-30 part, Fructus Schisandrae Chinensis 1-30 part, Fel Ursi 1-30 part, Semen Sesami Nigrum 1-30 part, Fructus Crataegi 1-30 part, Radix Rubiae 1-30 part, Poria 1-30 part, Herba Menthae 1-30 part, Fructus Lycii 1-30 part, Herba Leonuri 1-30 part, Herba Pyrolae 1-30 part, Semen Ziziphi Spinosae 1-30 part, Radix Sophorae Tonkinensis 1-30 part, Fructus Arctii 1-30 part, Radix Astragali 1-30 part.
3. one according to claim 2 treats ARR Chinese medicine composition, it is characterized in that: be made up of each component of following parts by weight:
Lignum Aquilariae Resinatum 1-15 part, Radix Codonopsis 1-15 part, Herba Ephedrae 1-15 part, Radix Glycyrrhizae 1-15 part, Rhizoma Paridis 1-15 part, salt Rhizoma Corydalis 1-15 part, Soviet Union and fragrant 1-15 part, Radix Glehniae 1-15 part, Fructus Schisandrae Chinensis 1-15 part, Fel Ursi 1-15 part, Semen Sesami Nigrum 1-15 part, Fructus Crataegi 1-15 part, Radix Rubiae 1-15 part, Poria 1-15 part, Herba Menthae 1-15 part, Fructus Lycii 1-15 part, Herba Leonuri 1-15 part, Herba Pyrolae 1-15 part, Semen Ziziphi Spinosae 1-15 part, Radix Sophorae Tonkinensis 1-15 part, Fructus Arctii 1-15 part, Radix Astragali 1-15 part.
4. treat ARR Chinese medicine composition according to the one described in claim 1 to 2, it is characterized in that: also comprise following parts by weight component: Herba Taraxaci 1-15 part, Radix Isatidis 1-15 part, Semen Ginkgo 1-15 part.
5. the one according to Claims 1-4 treats ARR Chinese medicine composition, it is characterized in that: also comprise following parts by weight component: Semen Sterculiae Lychnophorae 1-15 part, Aloe 1-15 part, Folium Sennae 1-15 part.
6. treat ARR Chinese medicine composition according to the one described in claim 1 to 5, it is characterized in that: the dosage form of described Chinese medicine preparation is: sublimed preparation, powder, injection, plaster, syrup, oral liquid, suck agent, granule, sugar coated tablet, film coated tablet, capsule.
7., according to a kind of preparation method for the treatment of ARR Chinese medicine composition described in claim 1 to 5, it is characterized in that: comprise the following steps:
(1) Herba Ephedrae, Rhizoma Paridis, salt Rhizoma Corydalis, Fructus Schisandrae Chinensis, Radix Rubiae, Herba Pyrolae, Radix Sophorae Tonkinensis, Fructus Arctii, the Radix Astragali, Semen Sterculiae Lychnophorae, Folium Sennae, Herba Taraxaci, Radix Isatidis, Semen Ginkgo raw material is got by medicine: the Capacity Ratio of water is 1: 2 ~ 10 soak at least 1 hour, add suitable quantity of water again to decoct 1 ~ 5 hour, elimination medicinal residues, under the condition of negative pressure, low temperature, the Chinese medicine leaching liquid of clarification being concentrated into Bomi degree is more than 80%, dry powder (temperature≤100 DEG C of spout) is made by powder spraying apparatus, for subsequent use;
(2) get Radix Codonopsis, ethanol that Radix Glehniae, Fructus Lycii, Herba Menthae, Poria, Aloe, Su Hexiang, Lignum Aquilariae Resinatum add 1-5 times amount, at 60-100 DEG C of alcoholization 50-120 minute, add the water of 1-5 times amount again, at 80 DEG C of insulation 50-120 minute, concentration and recovery ethanol, obtain mixed liquor, filter mixed liquor obtains filtrate, and the Chinese medicine residue of filtration repeats above extraction step; Merge twice filtrate, with aperture at 1000um, molecular cut off is in the high temperature resistant high rejection rolling NF membrane of 200KDalton, isolate the large particulate matter in filtrate and supernatant, supernatant concentration, at simmer down to 60 DEG C, relative density is the thick paste of 1.10 ~ 1.14, for subsequent use.
(3) get Fel Ursi, Herba Leonuri, Fructus Crataegi, Semen Sesami Nigrum, Semen Ziziphi Spinosae, Radix Glycyrrhizae pulverize and sieve, cross 200 mesh sieves, obtain drug powder.
(4) by above-mentioned steps (1), (2) and (3) mix homogeneously, gained mixture and described excipient substance are made required corresponding dosage form.
8. a kind of preparation method for the treatment of ARR Chinese medicine composition according to claim 7, is characterized in that: when described pharmaceutical dosage form is capsule, comprise the following steps:
(1) Herba Ephedrae, Rhizoma Paridis, salt Rhizoma Corydalis, Fructus Schisandrae Chinensis, Radix Rubiae, Herba Pyrolae, Radix Sophorae Tonkinensis, Fructus Arctii, the Radix Astragali, Semen Sterculiae Lychnophorae, Folium Sennae, Herba Taraxaci, Radix Isatidis, Semen Ginkgo raw material is got by medicine: the Capacity Ratio of water is 1: 2 ~ 10 soak at least 1 hour, add suitable quantity of water again to decoct 1 ~ 5 hour, elimination medicinal residues, under the condition of negative pressure, low temperature, the Chinese medicine leaching liquid of clarification being concentrated into Bomi degree is more than 80%, dry powder (temperature≤100 DEG C of spout) is made by powder spraying apparatus, for subsequent use;
(2) get Radix Codonopsis, ethanol that Radix Glehniae, Fructus Lycii, Herba Menthae, Poria, Aloe, Su Hexiang, Lignum Aquilariae Resinatum add 1-5 times amount, at 60-100 DEG C of alcoholization 50-120 minute, add the water of 1-5 times amount again, at 80 DEG C of insulation 50-120 minute, concentration and recovery ethanol, obtain mixed liquor, filter mixed liquor obtains filtrate, and the Chinese medicine residue of filtration repeats above extraction step; Merge twice filtrate, with aperture at 1000um, molecular cut off is in the high temperature resistant high rejection rolling NF membrane of 200KDalton, isolate the large particulate matter in filtrate and supernatant, supernatant concentration, at simmer down to 60 DEG C, relative density is the thick paste of 1.10 ~ 1.14, for subsequent use.
(3) get Fel Ursi, Herba Leonuri, Fructus Crataegi, Semen Sesami Nigrum, Semen Ziziphi Spinosae, Radix Glycyrrhizae pulverize and sieve, cross 200 mesh sieves, obtain drug powder.
(4) by above-mentioned steps (1), (2), (3) gained mix homogeneously, pulverize dry mixture, mixture is added capsule adjuvant, through granulating, drying and granulate obtain capsule particle, eventually pass that capsule is canned obtains capsule.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105434885A (en) * | 2016-01-27 | 2016-03-30 | 刘兆英 | Traditional Chinese medicine for treating Yin-deficiency and fire-excess type arrhythmia and preparation method |
| CN113499348A (en) * | 2021-07-05 | 2021-10-15 | 江西国妙堂生物医药科技有限公司 | Bear gall sugar-free buccal tablet and preparation method and application thereof |
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| CN102145128A (en) * | 2011-03-30 | 2011-08-10 | 呼伦贝尔松鹿制药有限公司 | Medicinal composition for preventing and treating cardiac and cerebral vascular diseases and preparation method thereof |
| CN103705850A (en) * | 2013-12-27 | 2014-04-09 | 唐立娟 | Traditional Chinese medicine for treating coronary heart disease |
| CN103933148A (en) * | 2014-03-19 | 2014-07-23 | 青岛市市立医院 | Pharmaceutical composition for prevention and treatment of arrhythmia and application thereof |
| CN104042912A (en) * | 2014-07-10 | 2014-09-17 | 崇州市地龙海龙生物制品开发研究所 | Method for preparing preparation used for treating coronary atherosclerotic heart disease |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101637564A (en) * | 2008-07-28 | 2010-02-03 | 北京中泰天和科技有限公司 | Chinese medicinal composition for resisting arrhythmia |
| CN102145128A (en) * | 2011-03-30 | 2011-08-10 | 呼伦贝尔松鹿制药有限公司 | Medicinal composition for preventing and treating cardiac and cerebral vascular diseases and preparation method thereof |
| CN103705850A (en) * | 2013-12-27 | 2014-04-09 | 唐立娟 | Traditional Chinese medicine for treating coronary heart disease |
| CN103933148A (en) * | 2014-03-19 | 2014-07-23 | 青岛市市立医院 | Pharmaceutical composition for prevention and treatment of arrhythmia and application thereof |
| CN104042912A (en) * | 2014-07-10 | 2014-09-17 | 崇州市地龙海龙生物制品开发研究所 | Method for preparing preparation used for treating coronary atherosclerotic heart disease |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105434885A (en) * | 2016-01-27 | 2016-03-30 | 刘兆英 | Traditional Chinese medicine for treating Yin-deficiency and fire-excess type arrhythmia and preparation method |
| CN113499348A (en) * | 2021-07-05 | 2021-10-15 | 江西国妙堂生物医药科技有限公司 | Bear gall sugar-free buccal tablet and preparation method and application thereof |
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