CN105434885A - Traditional Chinese medicine for treating Yin-deficiency and fire-excess type arrhythmia and preparation method - Google Patents

Traditional Chinese medicine for treating Yin-deficiency and fire-excess type arrhythmia and preparation method Download PDF

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CN105434885A
CN105434885A CN201610052743.2A CN201610052743A CN105434885A CN 105434885 A CN105434885 A CN 105434885A CN 201610052743 A CN201610052743 A CN 201610052743A CN 105434885 A CN105434885 A CN 105434885A
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radix
herba
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刘兆英
董学丽
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Abstract

The invention provides a traditional Chinese medicine for treating Yin-deficiency and fire-excess type arrhythmia and a preparation method. The traditional Chinese medicine is prepared from kelp roots, ternate grape fern herbs, Solanum cathayanum C. Y. Wu et S. C. Huang, rhizome of fourleaf paris, leaves or roots of littlefruit uvaria, roots of Szechwan indigo, fruit of greywhitehair raspberries, all-grass of ovalleaf coelogyne, civet, Chinese wedelia herbs, European hop flowers and ganoderma. The traditional Chinese medicine for treating the Yin-deficiency and fire-excess type arrhythmia and the preparation method have the advantages that the traditional Chinese medicine is combined with conventional drugs of western medicine to treat the Yin-deficiency and fire-excess type arrhythmia, the cure rate and the total effective rate are high, the effect is quick, and toxic and side effects and adverse reactions do not exist.

Description

One treats the ARR Chinese medicine of type of hyperactivity of fire caused by deficiency of YIN and preparation method
Technical field
The present invention relates to pharmaceutical technology, particularly relate to one and treat the ARR Chinese medicine of type of hyperactivity of fire caused by deficiency of YIN and preparation method.
Background technology
Arrhythmia (cardiacarrhythmia) is because the exciting exception of sinuatrial node or excitement result from beyond sinuatrial node; exciting conduction slowly, retardance or conduct through abnormal passage; namely the origin of cardiomotility and (or) conductive impairment cause frequency and (or) the allorhythmia of heartbeat; it is one of clinical modal Cardiovasculai appearance in patient; can be caused by factors such as various organic cardiovascular diseases, drug intoxication, electrolyte and acid base imbalance, part arrhythmia also can because of caused by autonomic nervous dysfunction.
The clinical manifestation of ARR hemodynamic responses depends primarily on ARR character, type, cardiac function and the degree to hemodynamic effects, as very little to hemodynamic effects in slight sinus bradycardia, arrhythmia, accidental atrial premature beat, first degree A-V block etc., therefore without obvious clinical manifestation.More serious arrhythmia, as sick sinus syndrome, rapid atrial fibrillation, paroxysmal supraventricular tachycardia, sustained ventricular tachycardia etc., cardiopalmus, uncomfortable in chest, dizzy, hypotension, perspiration can be caused, fainting can appear in severe patient, Adams Stokes syndrome, even die suddenly.Because ARR type is different, clinical manifestation is different.Mainly contain following several performance: 1. the performance of coronary insufficiency: various arrhythmia all can cause coronary artery blood flow to reduce, accidental atrial premature beat can make coronary artery blood flow lower 5%, accidental premature ventricular beat reduces by 12%, frequent premature ventricular beat can reduce by 25%, during atrial tachycardia, coronary artery blood flow reduces by 35%, Quick-type atrial fibrillation then can reduce by 40%, during ventricular tachycardia, coronary artery blood flow lowers 60%, and during ventricular fibrillation, coronary artery blood flow may be zero.The normal people of coronary artery, although various arrhythmia can cause coronary flow to reduce, lessly cause myocardial ischemia, but to the patient having coronary heart disease, various arrhythmia can be brought out or be increased the weight of myocardial ischemia.Main manifestations is angina pectoris, breathe hard, peripheral vessels exhaustion, acute heart failure, acute myocardial infarction etc.2. the performance of cerebral arterial insufficiency: different arrhythmia is also different on the impact of cerebral blood flow, frequent room and premature ventricular beat, cerebral blood flow declines 8% and 12% separately.Supraventricular tachycardia declines 14% ~ 23%, even reaches 40% when Ventricular Rate is exceedingly fast.Can 40% ~ 75% be reached during ventricular tachycardia.The normal person of cerebrovascular, above-mentioned hemodynamic obstacle is unlikely causes serious consequence.If during cerebrovascular generation pathological changes, be then enough to cause cerebral blood supply insufficiency, it shows as dizziness, weak, blurred vision, temporary total blindness, the even transient or permanent cerebral lesion such as aphasia, paralysis, tic, stupor.3. the performance of renal artery blood supply insufficiency: after arrhythmia occurs, different minimizings also occurs renal blood flow.The atrial premature beat that takes place frequently can make renal blood flow reduce by 8%, and the premature ventricular beat that takes place frequently makes renal blood flow reduce 10%; During atrial tachycardia, renal blood flow reduces by 18%; Rapid atria fibrillation and atrial flutter can reduce by 20%; Ventricular tachycardia then can lower 60%.Clinical manifestation has oliguria, albuminuria, azotemia etc.4. the performance of Mesenteric artery blood supply insufficiency: during tachy-arrhythmia, blood flow reduces by 34%, and series film artery spasm, can produce the clinical manifestation of gastrointestinal ischemia, as abdominal distention, stomachache, diarrhoea, hemorrhage, ulcer or paralysis even occurs.5. the performance of cardiac insufficiency: be mainly cough, dyspnea, asthenia, weak etc.
Treat when ARR treatment should comprise outbreak and prevent attacks.ARR treatment is the process of a relative complex.Except etiological treatment, still can be divided into Drug therapy and non-drug therapy two aspect.(1) Drug therapy: be ARR primary treatments.Due to ARR complexity, pharmaceutically-active mode and approach are also different.The application of general medicine is based on oral, and acute attack then adopts vein or aerosol medication.External used medicine application is less.Various due to arrhythmogenic mechanism complexity, many factors are also not bery clear, so clinical application acquires a certain degree of difficulty.Rule should according to ARR mechanism, and selection is with strong points, and curative effect is the little medicine of untoward reaction obviously.Drug therapy bradyarrhythmia generally selects the medicine strengthening autorhythmia of cardiac and (or) accelerate conduction, as sympathomimetic (isoproterenol etc.), vagus nerve suppress medicine (atropine) or basifier (mole sodium lactate or sodium bicarbonate).Treatment tachy-arrhythmia then selects the medicine of slow down conduction and prolongation refractory stage, as vagal excitation agent (neostigmine, digitalis preparation), sympathomimetic indirect excitation vagus nerve (methoxamedrine, phenylephrine) or antiarrhythmic drug.(2) electrical treatment: ARR electrical treatment development in recent years is very fast, existing electrical conversion in emergency circumstances, also has the ARR catheter ablation of radical cure.Mainly contain: 1. electrical conversion (synchronous or asynchronous): comprise the most frequently used external electrical conversion, surgery application through breast visceral pericardium electrical conversion, through esophagus electrical conversion, electrophysiologic study time the chambers of the heart in electrical conversion and ICD etc.Direct current countershock and electric defibrillation are respectively used to stop ectopic tachyarrhythmia outbreak and ventricular fibrillation, of short duration through thoracic wall effect or directly act on heart with high voltage direct current, make normal and abnormal pacemaker depolarization simultaneously, the highest pacemaker of recovery sinuatrial node.In order to ensure safety, utilizing the R ripple triggering discharges on patient ECG, avoiding the possibility of easily inviting phase depolarization generation ventricular fibrillation, being called Sync direct current shock, be applicable to atrium flutter quiver, atrial fibrillation, room property and supraventricular tachycardia turn multiple.Then with asynchronous unidirectional current defibrillation when treatment ventricular flutter and ventricular fibrillation.Electric defibrillation and electrical conversion curative effect rapidly, reliable and safety, be the primary treatments of the above-mentioned tachy-arrhythmia of Quick stop, but there is no the effect prevented attacks.2. electrostimulation: be a kind of rapid stimulation in esophagus or the chambers of the heart and stop ARR method.3. pacing therapy: cardiac pacemaker is used for treating bradyarrhythmia, stimulates atrium or ventricle with low-yield electric current regularly by preset frequency, maintains cardiomotility; Also be used for the treatment of reentrant tachy-arrhythmia and ventricular fibrillation, stimulate termination to turn back formation by programme controlled single or continuous fast electric.4. catheter ablation: the development of this method is very fast, and category and the indication for the treatment of are constantly expanded, and therapeutic effect is also become better and better.(3) mechanotherapy: such as vagus nerve stimulation, oppression eyeball, stimulation are pharyngeal etc.(4) operative treatment: comprise that bypass or slow channel cut off, long QT time sympathetic ganglion cut off, the operative treatment etc. of ventricular tachycardia.The vagal method of reflex excitation has oppression eyeball, massages carotid sinus, pinches nose forced expiration and get rid of gas etc.
Motherland's medical science there is no arrhythmia name of disease, according to its clinical manifestation be cardiopalmus, breathe hard, the symptom such as weak, uncomfortable in chest belongs to the category such as the traditional Chinese medical science " cardiopalmus ", " dry in the air and throb with fear ", " palpitation with a distress feeling ", " irregularly intermittent and regularly intermittent pulse ".System of Chinese medicine thinks the heart being a vital viscus like a king of the body, main promoting the circulation of blood arteries and veins and house mind is bright, and cardiopathia then QI and blood is driven in the wrong direction, and gods are uneasy, sends out as palpitation with fear, palpitation with a distress feeling.Modern doctor's majority advocates that the basic pathogenesis of cardiopalmus has deficiency and excess two aspect, and empty person is lost for negative and positive of qi and blood, lack of preservation of spirit and causing; Reality person is many freely not to be caused by the heart disturbed by phlegm-fire, the diseases caused by retention of fluid icepro heart and blood stasis resistance arteries and veins, QI-blood circulation, can mutually be mingled with or transform between deficiency and excess.Therefore clinical common deficiency in origin and excess in superficiality again, the card of the double folder of deficiency and excess.Deficiency in origin is negative and positive of qi and blood virtual loss, and heart arteries and veins is not flourish, and blood vessels must not fill, and agitates unable, and arteries and veins gas loses in continuously; Mark is real mostly is blood stasis, the stagnation of QI, cold-damp, expectorant are turbid, and the resistance of sering numbness is smooth, and heart hesitant pulse is stagnant, and beating, it is not normal to follow row.
Summary of the invention
Technical problem to be solved by this invention is, provides one to be used for the treatment of the ARR Chinese medicine of type of hyperactivity of fire caused by deficiency of YIN and preparation method, and this treatment by Chinese herbs type of hyperactivity of fire caused by deficiency of YIN arrhythmia has the advantage that determined curative effect, safety are high, have no side effect.
In order to solve the problems of the technologies described above, the invention provides one and treating the ARR Chinese medicine of type of hyperactivity of fire caused by deficiency of YIN, wherein, comprise following raw medicinal material: Radix Laminariae, Herba Botrychii, bittersweet, Radix Cynanchi Paniculati, Folium seu radix uvariae microcarpae, Radix Indigoferae Szechuenensis ， Fructus rubi tephrodis, Herba Coelogynes, Zibethum, Herbia Wedeliae, Flos Lupuli (Hops) and Herba Cassiopes selaginoidis.
Wherein, in described Chinese medicine, the ratio of weight and number of each raw medicinal material can be preferably: Radix Laminariae 30 ~ 40 parts, Herba Botrychii 25 ~ 35 parts, bittersweet 30 ~ 40 parts, Radix Cynanchi Paniculati 20 ~ 30 parts, Folium seu radix uvariae microcarpae 20 ~ 30 parts, Radix Indigoferae Szechuenensis 10 ~ 20 parts of ， Fructus rubi tephrodis 10 ~ 20 parts, Herba Coelogynes 15 ~ 25 parts, Zibethum 5 ~ 15 parts, Herbia Wedeliae 20 ~ 30 parts, Flos Lupuli (Hops) 20 ~ 35 parts and Herba Cassiopes selaginoidis 15 ~ 30 parts.
Wherein, in described Chinese medicine, the ratio of weight and number of each raw medicinal material can be preferably: Radix Laminariae 35 ~ 40 parts, Herba Botrychii 25 ~ 30 parts, bittersweet 30 ~ 35 parts, Radix Cynanchi Paniculati 20 ~ 25 parts, Folium seu radix uvariae microcarpae 25 ~ 30 parts, Radix Indigoferae Szechuenensis 10 ~ 15 parts of ， Fructus rubi tephrodis 15 ~ 20 parts, Herba Coelogynes 20 ~ 25 parts, Zibethum 5 ~ 10 parts, Herbia Wedeliae 25 ~ 30 parts, Flos Lupuli (Hops) 25 ~ 35 parts and Herba Cassiopes selaginoidis 20 ~ 30 parts.
Wherein, in described Chinese medicine, the ratio of weight and number of each raw medicinal material can be preferably: Radix Laminariae 38 parts, Herba Botrychii 26 parts, bittersweet 32 parts, Radix Cynanchi Paniculati 23 parts, Folium seu radix uvariae microcarpae 26 parts, Radix Indigoferae Szechuenensis 12 parts of ， Fructus rubi tephrodis 17 parts, Herba Coelogynes 22 parts, Zibethum 9 parts, Herbia Wedeliae 28 parts, Flos Lupuli (Hops) 26 parts and Herba Cassiopes selaginoidis 25 parts.
Wherein, in described Chinese medicine, the ratio of weight and number of each raw medicinal material can be preferably: Radix Laminariae 36 parts, Herba Botrychii 29 parts, bittersweet 35 parts, Radix Cynanchi Paniculati 21 parts, Folium seu radix uvariae microcarpae 27 parts, Radix Indigoferae Szechuenensis 14 parts of ， Fructus rubi tephrodis 15 parts, Herba Coelogynes 24 parts, Zibethum 6 parts, Herbia Wedeliae 26 parts, Flos Lupuli (Hops) 32 parts and Herba Cassiopes selaginoidis 22 parts.
When the dosage form of described Chinese medicine is capsule, its preparation method comprises the following steps:
The first step, by Radix Laminariae, Herba Botrychii, bittersweet, Radix Cynanchi Paniculati and Folium seu radix uvariae microcarpae mix in described ratio, add the water extraction volatile oil relative to 4 ~ 6 times, mixture, by the volatile oil beta-cyclodextrin inclusion compound obtained, the ratio of volatile oil and beta-schardinger dextrin-is 1:3 ~ 6, stir 65 minutes ~ 90 minutes, temperature 30 DEG C ~ 45 DEG C, obtains volatile oil clathrate compound, for subsequent use; Another when aqueous extract being concentrated into 60 DEG C relative density be the clear paste of 1.15 ~ 1.17;
Second step is Jiang Fructus rubi tephrodis, Herba Coelogynes and Zibethum mix in described ratio, add relative to mixture 5 ~ 8 times amount determining alcohol be 80% ~ 90% alcohol reflux 3 ~ 5 times, each 2 ~ 3 hours, filter, filtrate merges, reclaim ethanol, when being concentrated into 60 DEG C, relative density is the clear paste of 1.20 ~ 1.22, for subsequent use;
3rd step, will remain described raw medicinal material and mix in described ratio, add relative to mixture 8 ~ 10 times of water gagings, boil 6 ~ 8 hours, filter, and when being concentrated into 60 DEG C, relative density is the clear paste of 1.28 ~ 1.30;
4th step, mixed by the clear paste of the first step, second step, the 3rd step, 60 DEG C ~ 70 DEG C reduced vacuum dryings, get dry extract powder;
5th step, dried cream powder described in volatile oil clathrate compound described in the first step and the 4th step is fully mixed, subsequently relative to the mixture of volatile oil clathrate compound described in 100 weight portions and dried cream powder, add 5 ~ 7 weight portion carboxymethyl starch sodium, 5 ~ 50 weight starch mix homogeneously, adding 150 ~ 200 weight portion determining alcohols is 80% ~ 90% alcohol granulation, dry, granulate, subsequently relative to the mixture of volatile oil clathrate compound described in 100 weight portions and dried cream powder, add 3 ~ 5 weight portion magnesium stearate, then load in gelatine capsule.
When the dosage form of described Chinese medicine is syrup, its preparation method comprises the following steps:
The first step, by Radix Laminariae, Herba Botrychii, bittersweet, Radix Cynanchi Paniculati and Folium seu radix uvariae microcarpae mix in described ratio, adding relative to the determining alcohol of 4 ~ 6 times, mixture is the ethanol of 80% ~ 90%, heating and refluxing extraction 2 ~ 4 times, each reflux, extract, 2 hours ~ 3 hours, merge extractive liquid, with the centrifugal remove impurity of tube centrifuge, when the extracting solution after remove impurity being evaporated under the condition of 65 DEG C ~ 70 DEG C 60 DEG C, relative density is the medicinal liquid of 1.05 ~ 1.10, by dry with spray dryer for the concentrated solution after concentrated, be ground into 100 ~ 200 orders subsequently, obtain dry powder;
Second step, Jiang Fructus rubi tephrodis, Herba Coelogynes and Zibethum mix in described ratio, be ground into powder, with determining alcohol be the ethanol of 85% ~ 95% as solvent, flood 48 hours ~ 72 hours, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being concentrated into 65 DEG C, relative density is the mastic of 1.25 ~ 1.27, dry with spray dryer, is ground into 150 ~ 200 orders subsequently, obtain dry powder, the quality of the ethanol added is 3 ~ 5 times of second step mixture quality;
3rd step, surplus stock medical material is mixed in described ratio, add relative to mixture 4 ~ 6 times amount determining alcohol be 70% ~ 80% alcohol reflux 2 ~ 4 times, each 1 hour ~ 3 hours, filter, filtrate merges, reclaim ethanol, when being concentrated into 60 DEG C, relative density is the mastic of 1.20 ~ 1.22, in 55 DEG C ~ 65 DEG C reduced vacuum dryings, obtains dry powder;
4th step, by the dry powder blend that the first step obtains to the 3rd step, add the water dissolution relative to mixture quality 3 ~ 5 times, by 40% sodium hydroxide solution adjust ph to 7.0, add correctives sucrose, antiseptic mix homogeneously subsequently, obtain syrup, the correctives added, antiseptic and the content in medicine thereof: sucrose 30 ~ 60%, Pyrusussuriensis acids antiseptic are if potassium sorbate 0.1 ~ 0.3%, paraben preservative are as ethyl hydroxybenzoate 0.01 ~ 0.05.
Beneficial effect of the present invention: Chinese medicine of the present invention, associating doctor trained in Western medicine routine administration treatment type of hyperactivity of fire caused by deficiency of YIN arrhythmia, has cure rate and total effective rate is high, rapid-action, have no side effect and the advantage of untoward reaction.
Detailed description of the invention
The invention provides one and treat the ARR Chinese medicine of type of hyperactivity of fire caused by deficiency of YIN, wherein, comprise following raw medicinal material: Radix Laminariae, Herba Botrychii, bittersweet, Radix Cynanchi Paniculati, Folium seu radix uvariae microcarpae, Radix Indigoferae Szechuenensis ， Fructus rubi tephrodis, Herba Coelogynes, Zibethum, Herbia Wedeliae, Flos Lupuli (Hops) and Herba Cassiopes selaginoidis.
Wherein, the pharmacology of above-mentioned raw materials medical material is as follows:
Radix Laminariae: [source] medical material Ji Yuan: be the holdfast of Laminariaceae plant Thallus Laminariae (Thallus Eckloniae) (Thallus Laminariae (Thallus Eckloniae)).[nature and flavor] are salty; Cold.[return through] lung; Liver Channel.[function cures mainly] removing heat-phlegm; Cough-relieving; Suppressing the hyperactive liver.Main phlegm-heat cough; The dizziness that liver-yang is partially high; Headache; Being irritable and getting angry easily; Little sleep disturbed by dreams.[extracts] " China's book on Chinese herbal medicine " " Chinese medicine voluminous dictionary "
Herba Botrychii: [another name] YIDUOYUN, flower Herba pteridii latiusculi, independent golden pheasant, unipods Artemisia, winter grass, youth's beanstalk Herba Asari, back of the body Serpentis life, Potianyun, fall apart blood leaf, little spring flower, Herba Botrychii, hang the good branch of bamboo, good branch grass, unipods golden pheasant, Osmanthus tragranscv.Aurantiacu move star grass, Rhizoma Coptidis seven, JIZHUALIAN.[source] medical material Ji Yuan: be the herb of Botrychiaceae plant Herba Botrychii.[nature and flavor] are sweet; Bitter; Cool; Be slightly cold.[return through] lung; Liver Channel.[function cures mainly] heat-clearing and toxic substances removing; Suppressing the hyperactive liver to relieve the wind syndrome; Cough-relieving; Hemostasis; Improving eyesight removing nebula.Main infantile hyperpyrexia is frightened jerks; Cough due to lung-heat; Hemoptysis; Pertussis; Demented; Epilepsy disease; Sore swollen toxin; Scrofula; Venom; Conjunctival congestion acute catarrhal conjunctivitis; The raw cataracta of order.[extracts] " China's book on Chinese herbal medicine " " Chinese medicine voluminous dictionary "
Bittersweet: [another name] Herba Solani Lyrati, wild Fructus Lycopersici esculenti, Herba Solani Lyrati, Herba seu Fructus Physalis Minimae, magnificent Herba Solani Lyrati, false Fructus Capsici, Ou Baiqie, Fructus Solani Dulcamarae, Solanum lyratum Thunb., hair Caulis et Folium cayratiae trifoliae.[source] medical material Ji Yuan: be the herb of the plant of Solanaceae hair year not rotten heart.[nature and flavor] sweet in the mouth; Bitter; Cold in nature.[function cures mainly] heat-clearing and toxic substances removing; Dispelling wind and relieving convulsion.Main fever of children infantile convulsion; Jaundice; Cough due to lung-heat; Acute toothache; Scrofula; Woman uterine bleeding, leukorrhagia, pelvic inflammatory disease.[extracts] " China's book on Chinese herbal medicine "
Radix Cynanchi Paniculati: [another name] subduing the wind syndrome muscle, copper chopsticks, lamp-stand seven, Rhizoma Paridis.[source] medical material Ji Yuan: be the rhizome of liliaceous plant north Rhizoma Paridis.Gather and store: excavating at the beginning of autumn late summer, removing stem and leaf and fibrous root, cleans, using fresh herb or dry.[nature and flavor] are bitter; Cold; Slightly poisonous.[function cures mainly] expelling wind and removing dampness; Heat clearing away is calmed the frightened; Removing toxic substances and promoting subsidence of swelling.Main air pain of dampness syndrome; Calentura is twitched; Laryngopharynx swelling and pain; Carbuncle; Scrofula; Venom.[extracts] " China's book on Chinese herbal medicine "
Folium seu radix uvariae microcarpae: [another name] Folium desmoris, oily vertebra, any of several broadleaf plants rattan, wine pancake, butcher's knife tree, cattle M.-dodecandrum, ox head sieve, wine cake wood, milk fruit, SHILONG leaf, native Folium Eriobotryae, mountain stalk, little ten eight winds coming from eight orientations rattans.[source] medical material Ji Yuan: be leaf or the root of annonaceae plant Uvaria microcarpa.Gather and store: the whole year all can gather, cleaning, using fresh herb or dry.[nature and flavor] are pungent; Bitter; Slightly warm in nature.[return through] liver; Stomach warp.[function cures mainly] expelling wind and removing dampness; Circulation of qi promoting stomach invigorating; Pain relieving; Preventing phlegm from forming and stopping coughing.Main air pain of dampness syndrome; Lumbago and skelalgia; Traumatic injury; Dyspepsia; Abdominal distention is suffered from diarrhoea; Cough with copious phlegm.[extracts] " China's book on Chinese herbal medicine "
Radix Indigoferae Szechuenensis: [another name] Flos Caraganae Sinicae.[source] medical material Ji Yuan: be root or the aerial parts of leguminous plant Sichuan Drymotaenium miyoshianum (Mak.) Mak..Gather and store: the whole year all can gather, clean, using fresh herb or cutting are dried.[nature and flavor] are pungent; Bitter; Tepor.[return through] liver; Stomach; Lung meridian.[function cures mainly] regulating the flow of QI to ease the stomach; Heat-clearing and toxic substances removing.Main gastric abscess; Tripe abdomen cold type of pain; Chest and diaphragm distension; Pulmonary tuberculosis is generated heat; Sore swollen toxin.[extracts] " China's book on Chinese herbal medicine "
Fructus rubi tephrodis: [another name] covers basin, Ling Lei, Yin Lei, cuts field Fischer, the cold certain kind of berries, cold Fischer.[source] medical material Ji Yuan: be the fruit of rosaceous plant Rubus tephrodes.[nature and flavor] sweet acid; Temperature.[return through] liver, kidney channel.[function cures mainly] the kidney invigorating and essence nourishing, reducing urination.Main polyuria, sexual impotence, sterile, early whitening of beard and hair, carbuncle.[each discussion] 1. " herbal classic ": main settling five organs, beneficial vital essence, and long cloudy order is hard, and strong will times power, has son.2. " not Lu ": treat sudden and violent apoplexy, fever of the body is frightened.3. Tang Materia Medica: resistance to cold-damp, good color.4. " daily book on Chinese herbal medicine ": urine reducing, black and white is sent out.5. " medical center bun is wanted ": tonifying the lung, cold removing.[extracts] " China's book on Chinese herbal medicine "
Herba Coelogynes: [another name] Ephemerantha pallens (Ridley) Hunt et Summerh..[source] medical material Ji Yuan: be the herb of orchid Herba Coelogynes.Gather and store: the 7-9 month gathers, cleaning, dry after steaming.[nature and flavor] are sweet; Light; Cool.[return through] lung; Stomach; Kidney channel.[function cures mainly] nourishing the stomach to promote the production of body fluid; Nourishing YIN for benefiting the kidney.Main consumption of body fluid caused by febrile disease; Weak after being ill; Tuberculosis hectic fever; Night sweat; Chronic gastritis; Achlorhydria; Inappetence; Seminal emission; The soreness of waist is unable; Hemorrhoid.[extracts] " China's book on Chinese herbal medicine "
Zibethum: [source] medical material Ji Yuan: be the secretions in Viverridae animal zibet, rasse scent gland capsule.[nature and flavor] acrid in the mouth; Warm in nature; [return through] heart; Liver Channel.[function cures mainly] wards off dirty; Circulation of qi promoting; Pain relieving.Main sudden attack of pain in the chest and abdomen; Colicky; Angina pectoris; Stomachache; Pestilential pathogen.[each discussion] 1. supplement to the Herbal: main attacked by pestiferous factors, sudden attack of pain in the chest and abdomen, malaria, pestilential pathogen, tranquilizing mind.[extracts] " China's book on Chinese herbal medicine "
Herbia Wedeliae: [another name] Flos Chrysanthemi Indici, Herba Kalimeridis grass, Sesarmae dehaani is colored, water is blue, Herba Wedeliae Prostratae, Hemerocallis citrina Baroni Herba Otteliae Alismoidis, Hemerocallis citrina Baroni Anacamptis pyromaidalis, liatris, Hemerocallis citrina Baroni ink dish, Herba Otteliae Alismoidis.[source] medical material Ji Yuan: be the herb of feverfew Herbia Wedeliae.Gather and store: herb of gathering in spring, summer, autumn uproots, and using fresh herb or cutting are dried.[nature and flavor] mildly bitter flavor; Sweet; Cool in nature.[function cures mainly] heat-clearing and toxic substances removing; Cool the blood dissipate blood stasis.Main cold, fever; Pharyngolaryngitis; Tonsillitis; Rib adenitis; Diphtheria; Pertussis; Tracheitis; Pneumonia; Hemoptysis of pulmonary tuberculosis; Epistaxis; Hematuria; Infectious hepatitis; Dysentery; Hemorrhoid; Furuncle insane asylum toxic swelling.[each discussion] be " the SHENGCAO property of medicine is standby to be wanted " 1.: loose skin ulcer, heat clearing away, pus of tut-tuting, wears skin ulcer, complication, hemorrhoid.Its root energy debentition.2. " register planted by Guangxi medicine ": removing blood stasis with potent drugs, subside a swelling.Control traumatic injury, stomachache, rheumatism.3. " Fujian Chinese herbal medicine ": heat-clearing and toxic substances removing.Control diphtheria, pertussis, pulmonary tuberculosis fever and cough, dysentery, high liver fire, dysphoria with smothery sensation sleeplessness, laryngopharynx swelling and pain, gingivitis.[extracts] " China's book on Chinese herbal medicine "
Flos Lupuli (Hops): [another name] hops, Flos lupuli, Flos lupuli (Flos Humuli Lupuli), Fols lupuli, hops.[source] medical material Ji Yuan: be the wounded in the battle fruit ear of immaturity of moraceae plants China hops.Gather and store: summer, autumn are spent when just opening and pluck, and dry in the shade or dry.[nature and flavor] property is bitter; Property is put down.[function cures mainly] spleen invigorating; Calm the nerves; Anti-consumptive disease; Diuresis.Main dyspepsia; Anorexia; Hysteria; Insomnia; Consumptive disease is coughed; Cystitis.[extracts] " China's book on Chinese herbal medicine "
Herba Cassiopes selaginoidis: [another name] ferrum brush handle, Rohdea japonica Roth, phlegmariurus hamictonii (Sprengel) Love et love varpeti-olaius (Clarke) Ching, Herba arenariae kansuensis, Herba Swertiae davidi, Debregeasia orientalis C. J. Chen are yellow.[source] medical material Ji Yuan: be the Herb of ericad rock palpus.Gather and store: summer, autumn gather, and cutting is dried.[nature and flavor] are pungent; Micro-hardship; Property is put down.[return through] heart; Liver; Stomach warp.[function cures mainly] circulation of qi promoting; Invigorate blood circulation; Pain relieving; Calm the nerves.Main stagnation of liver-QI and stomach-QI; Xie Lei institute abdominal distention and pain; Rheumatic arthralgia; Traumatic injury; Insomnia.[each discussion] " Xinhua's book on Chinese herbal medicine outline ": Herb: acrid in the mouth, micro-hardship, property is put down.There are promoting the circulation of QI to relieve pain, mind-easing function.For stomachache due to hyperactive liver-QI attacking the stomach, inappetence, neurasthenia.[extracts] " China's book on Chinese herbal medicine "
Wherein, in described Chinese medicine, the ratio of weight and number of each raw medicinal material can be preferably: Radix Laminariae 30 ~ 40 parts, Herba Botrychii 25 ~ 35 parts, bittersweet 30 ~ 40 parts, Radix Cynanchi Paniculati 20 ~ 30 parts, Folium seu radix uvariae microcarpae 20 ~ 30 parts, Radix Indigoferae Szechuenensis 10 ~ 20 parts of ， Fructus rubi tephrodis 10 ~ 20 parts, Herba Coelogynes 15 ~ 25 parts, Zibethum 5 ~ 15 parts, Herbia Wedeliae 20 ~ 30 parts, Flos Lupuli (Hops) 20 ~ 35 parts and Herba Cassiopes selaginoidis 15 ~ 30 parts.
Wherein, in described Chinese medicine, the ratio of weight and number of each raw medicinal material can be preferably: Radix Laminariae 35 ~ 40 parts, Herba Botrychii 25 ~ 30 parts, bittersweet 30 ~ 35 parts, Radix Cynanchi Paniculati 20 ~ 25 parts, Folium seu radix uvariae microcarpae 25 ~ 30 parts, Radix Indigoferae Szechuenensis 10 ~ 15 parts of ， Fructus rubi tephrodis 15 ~ 20 parts, Herba Coelogynes 20 ~ 25 parts, Zibethum 5 ~ 10 parts, Herbia Wedeliae 25 ~ 30 parts, Flos Lupuli (Hops) 25 ~ 35 parts and Herba Cassiopes selaginoidis 20 ~ 30 parts.
Wherein, in described Chinese medicine, the ratio of weight and number of each raw medicinal material can be preferably: Radix Laminariae 38 parts, Herba Botrychii 26 parts, bittersweet 32 parts, Radix Cynanchi Paniculati 23 parts, Folium seu radix uvariae microcarpae 26 parts, Radix Indigoferae Szechuenensis 12 parts of ， Fructus rubi tephrodis 17 parts, Herba Coelogynes 22 parts, Zibethum 9 parts, Herbia Wedeliae 28 parts, Flos Lupuli (Hops) 26 parts and Herba Cassiopes selaginoidis 25 parts.
Wherein, in described Chinese medicine, the ratio of weight and number of each raw medicinal material can be preferably: Radix Laminariae 36 parts, Herba Botrychii 29 parts, bittersweet 35 parts, Radix Cynanchi Paniculati 21 parts, Folium seu radix uvariae microcarpae 27 parts, Radix Indigoferae Szechuenensis 14 parts of ， Fructus rubi tephrodis 15 parts, Herba Coelogynes 24 parts, Zibethum 6 parts, Herbia Wedeliae 26 parts, Flos Lupuli (Hops) 32 parts and Herba Cassiopes selaginoidis 22 parts.
When the dosage form of described Chinese medicine is capsule, its preparation method comprises the following steps:
The first step, by Radix Laminariae, Herba Botrychii, bittersweet, Radix Cynanchi Paniculati and Folium seu radix uvariae microcarpae mix in described ratio, add the water extraction volatile oil relative to 4 ~ 6 times, mixture, by the volatile oil beta-cyclodextrin inclusion compound obtained, the ratio of volatile oil and beta-schardinger dextrin-is 1:3 ~ 6, stir 65 minutes ~ 90 minutes, temperature 30 DEG C ~ 45 DEG C, obtains volatile oil clathrate compound, for subsequent use; Another when aqueous extract being concentrated into 60 DEG C relative density be the clear paste of 1.15 ~ 1.17;
Second step is Jiang Fructus rubi tephrodis, Herba Coelogynes and Zibethum mix in described ratio, add relative to mixture 5 ~ 8 times amount determining alcohol be 80% ~ 90% alcohol reflux 3 ~ 5 times, each 2 ~ 3 hours, filter, filtrate merges, reclaim ethanol, when being concentrated into 60 DEG C, relative density is the clear paste of 1.20 ~ 1.22, for subsequent use;
3rd step, will remain described raw medicinal material and mix in described ratio, add relative to mixture 8 ~ 10 times of water gagings, boil 6 ~ 8 hours, filter, and when being concentrated into 60 DEG C, relative density is the clear paste of 1.28 ~ 1.30;
4th step, mixed by the clear paste of the first step, second step, the 3rd step, 60 DEG C ~ 70 DEG C reduced vacuum dryings, get dry extract powder;
5th step, dried cream powder described in volatile oil clathrate compound described in the first step and the 4th step is fully mixed, subsequently relative to the mixture of volatile oil clathrate compound described in 100 weight portions and dried cream powder, add 5 ~ 7 weight portion carboxymethyl starch sodium, 5 ~ 50 weight starch mix homogeneously, adding 150 ~ 200 weight portion determining alcohols is 80% ~ 90% alcohol granulation, dry, granulate, subsequently relative to the mixture of volatile oil clathrate compound described in 100 weight portions and dried cream powder, add 3 ~ 5 weight portion magnesium stearate, then load in gelatine capsule.
When the dosage form of described Chinese medicine is syrup, its preparation method comprises the following steps:
The first step, by Radix Laminariae, Herba Botrychii, bittersweet, Radix Cynanchi Paniculati and Folium seu radix uvariae microcarpae mix in described ratio, adding relative to the determining alcohol of 4 ~ 6 times, mixture is the ethanol of 80% ~ 90%, heating and refluxing extraction 2 ~ 4 times, each reflux, extract, 2 hours ~ 3 hours, merge extractive liquid, with the centrifugal remove impurity of tube centrifuge, when the extracting solution after remove impurity being evaporated under the condition of 65 DEG C ~ 70 DEG C 60 DEG C, relative density is the medicinal liquid of 1.05 ~ 1.10, by dry with spray dryer for the concentrated solution after concentrated, be ground into 100 ~ 200 orders subsequently, obtain dry powder;
Second step, Jiang Fructus rubi tephrodis, Herba Coelogynes and Zibethum mix in described ratio, be ground into powder, with determining alcohol be the ethanol of 85% ~ 95% as solvent, flood 48 hours ~ 72 hours, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being concentrated into 65 DEG C, relative density is the mastic of 1.25 ~ 1.27, dry with spray dryer, is ground into 150 ~ 200 orders subsequently, obtain dry powder, the quality of the ethanol added is 3 ~ 5 times of second step mixture quality;
3rd step, surplus stock medical material is mixed in described ratio, add relative to mixture 4 ~ 6 times amount determining alcohol be 70% ~ 80% alcohol reflux 2 ~ 4 times, each 1 hour ~ 3 hours, filter, filtrate merges, reclaim ethanol, when being concentrated into 60 DEG C, relative density is the mastic of 1.20 ~ 1.22, in 55 DEG C ~ 65 DEG C reduced vacuum dryings, obtains dry powder;
4th step, by the dry powder blend that the first step obtains to the 3rd step, add the water dissolution relative to mixture quality 3 ~ 5 times, by 40% sodium hydroxide solution adjust ph to 7.0, add correctives sucrose, antiseptic mix homogeneously subsequently, obtain syrup, the correctives added, antiseptic and the content in medicine thereof: sucrose 30 ~ 60%, Pyrusussuriensis acids antiseptic are if potassium sorbate 0.1 ~ 0.3%, paraben preservative are as ethyl hydroxybenzoate 0.01 ~ 0.05.
Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure reaching technique effect can fully understand and implement according to this.
Embodiment 1: capsule of the present invention
Get Radix Laminariae 360g, Herba Botrychii 290g, bittersweet 350g, Radix Cynanchi Paniculati 210g, Folium seu radix uvariae microcarpae 270g, Radix Indigoferae Szechuenensis 140g ， Fructus rubi tephrodis 150g, Herba Coelogynes 240g, Zibethum 60g, Herbia Wedeliae 260g, Flos Lupuli (Hops) 320g and Herba Cassiopes selaginoidis 220g;
Its preparation method comprises the following steps:
The first step, by Radix Laminariae, Herba Botrychii, bittersweet, Radix Cynanchi Paniculati and Folium seu radix uvariae microcarpae mix in described ratio, add the water extraction volatile oil relative to 6 times, mixture, by the volatile oil beta-cyclodextrin inclusion compound obtained, the ratio of volatile oil and beta-schardinger dextrin-is 1:5, stir 80 minutes, temperature 45 C, obtains volatile oil clathrate compound, for subsequent use; Another when aqueous extract being concentrated into 60 DEG C relative density be the clear paste of 1.16;
Second step, Jiang Fructus rubi tephrodis, Herba Coelogynes and Zibethum mix in described ratio, add relative to mixture 6 times amount determining alcohol be 90% alcohol reflux 4 times, each 2 hours, filter, filtrate merges, reclaim ethanol, when being concentrated into 60 DEG C, relative density is the clear paste of 1.22, for subsequent use;
3rd step, will remain described raw medicinal material and mix in described ratio, add relative to mixture 10 times of water gagings, boil 8 hours, filter, and when being concentrated into 60 DEG C, relative density is the clear paste of 1.29;
4th step, mixed by the clear paste of the first step, second step, the 3rd step, 70 DEG C of reduced vacuum dryings, get dry extract powder;
5th step, dried cream powder described in volatile oil clathrate compound described in the first step and the 4th step is fully mixed, subsequently relative to the mixture of volatile oil clathrate compound described in 100 weight portions and dried cream powder, add 7 weight portion carboxymethyl starch sodium, 36 weight starch mix homogeneously, adding 180 weight portion determining alcohols is 80% alcohol granulation, dry, granulate, subsequently relative to the mixture of volatile oil clathrate compound described in 100 weight portions and dried cream powder, add 5 weight portion magnesium stearate, then load in gelatine capsule.
Embodiment 2: syrup of the present invention
Get Radix Laminariae 380g, Herba Botrychii 260g, bittersweet 320g, Radix Cynanchi Paniculati 230g, Folium seu radix uvariae microcarpae 260g, Radix Indigoferae Szechuenensis 120g ， Fructus rubi tephrodis 170g, Herba Coelogynes 220g, Zibethum 90g, Herbia Wedeliae 280g, Flos Lupuli (Hops) 260g and Herba Cassiopes selaginoidis 250g;
Its preparation method comprises the following steps:
The first step, by Radix Laminariae, Herba Botrychii, bittersweet, Radix Cynanchi Paniculati and Folium seu radix uvariae microcarpae mix in described ratio, and adding relative to the determining alcohol of 6 times, mixture is the ethanol of 90%, heating and refluxing extraction 4 times, each reflux, extract, 3 hours, merge extractive liquid, with the centrifugal remove impurity of tube centrifuge, when the extracting solution after remove impurity being evaporated under the condition of 65 DEG C 60 DEG C, relative density is the medicinal liquid of 1.10, by dry with spray dryer for the concentrated solution after concentrated, be ground into 200 orders subsequently, obtain dry powder;
Second step, Jiang Fructus rubi tephrodis, Herba Coelogynes and Zibethum mix in described ratio, be ground into powder, with determining alcohol be the ethanol of 90% as solvent, flood 60 hours, adopt percolation with the speed of 1ml per minute slowly percolation, collect percolate, when being concentrated into 65 DEG C, relative density is the mastic of 1.27, dry with spray dryer, is ground into 200 orders subsequently, obtain dry powder, the quality of the ethanol added is 5 times of second step mixture quality;
3rd step, mixes surplus stock medical material in described ratio, add relative to mixture 5 times amount determining alcohol be 80% alcohol reflux 2 times, each 3 hours, filter, filtrate merges, and reclaims ethanol, when being concentrated into 60 DEG C, relative density is the mastic of 1.22, in 65 DEG C of reduced vacuum dryings, obtains dry powder;
4th step, by the dry powder blend that the first step obtains to the 3rd step, add the water dissolution relative to mixture quality 4.4 times, by 40% sodium hydroxide solution adjust ph to 7.0, add correctives sucrose, antiseptic mix homogeneously subsequently, obtain syrup, the correctives added, antiseptic and the content in medicine thereof: sucrose 37%, potassium sorbate 0.18%.
Toxicity test:
Acute toxicity testing: application mice 60, male and female half and half, body weight 30 ~ 40g, carries out acute toxicity test.Mice is divided into two groups at random, i.e. matched group and administration group, before experiment, fasting 12 hours, is dissolved in water by Chinese medicine capsules prepared by embodiments of the invention 1, (concentration is 8.25g crude drug/ml, maximum concentration) gavage, gavage volume is 5ml/kg (namely unit dosage form is 41.25 crude drugs/kg), and matched group gives normal saline, administration in one day 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record mice toxic reaction and death toll.Experimental result shows: compare with matched group, and after administration, mice has no notable difference, and experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increase all normal.Mouse oral gavage capsule LD50>41.25 crude drug/kg of the present invention, every day, maximum dosage-feeding was 82.5 crude drugs/kg/ day.Chinese medicine clinical application amount of the present invention be 8.36g crude drug/day/people, adult body weight in 60KG, average dosage is 0.139g crude drug/kg/ day.By weighing machine: the dosis tolerata of mice (average weight is in 35g) oral administration gavage Chinese medicine of the present invention is 594 times of quantity.Therefore Chinese medicine acute toxicity of the present invention is extremely low, clinical drug safety.
Long term toxicity test: Chinese medicine embodiment 1 capsule of the present invention to three groups of mices (often organize 20) by 13.26,23.28 and 42.18g crude drug/kg continuous use 15 weeks (1.0ml/100g body weight, every day 2 times) and drug withdrawal after 3 weeks, result shows: the index such as hair, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of Chinese medicine of the present invention to mice all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 15 weeks and drug withdrawal are after 3 weeks, and Organs of Mice is all without obviously changing.Illustrate that Chinese medicine of the present invention is little to toxicity after mice long-term prescription, also there is no difference reaction after drug withdrawal, application safety.
Clinical data:
Case selection: fetch the 96 routine type of hyperactivity of fire caused by deficiency of YIN patients with arrhythmia coming from the court's Cardiological outpatient service or be in hospital, male 51 people, female 45 people; 25 ~ 67 years old age.Patient is divided into treatment group and matched group at random, wherein, treatment group 48 people, male 26 people, female 22 people; 25 ~ 67 years old age.Matched group 48 people, male 25 people, female 23 people; 25 ~ 67 years old age.Two groups of patients no difference of science of statistics in sex, age and clinical symptoms, has comparability.
Diagnostic criteria:
Western medicine diagnose standard: meet various ARR diagnostic criteria in " clinical disease diagnosis and the curative effect judging standard " that hospital associate of Hunan Province writes, and all make a definite diagnosis through electrocardiogram, ambulatory electrocardiogram etc. inspections.
Syndrome Types of TCM standard: type of hyperactivity of fire caused by deficiency of YIN: palpitation and uneasiness, fidgetyly sleeps less, has a dizzy spell, dryness of the mouth and throat, or aphthous stomatitis, dysphoria with feverish sensation in the chest palms and soles, night sweat, and the soreness of waist is rare soft; Red tongue, few tongue or no fur, thready and rapid pulse.
Therapeutic Method:
Matched group: adopt western medicine routine treatment, give lignocaine or amiodarone on treating, artrial premature beat gives propranolol or Propafenone in Treating, atrial fibrillation gives cedilanid treatment, ventricular premature contraction gives amiodarone on treating, paroxysmal supraventricular tachycardia gives beta-blocker treatment, and atrioventricular block gives isoproterenol treatment; Within 2 weeks, be 1 course for the treatment of, treat 2 courses for the treatment of, check an electrocardiogram weekly.
Treatment group: on matched group western medicine routine treatment basis, takes capsule prepared by the embodiment of the present invention 1, every day 3 times, each 3 simultaneously; Within 2 weeks, be 1 course for the treatment of, treat 2 courses for the treatment of, check an electrocardiogram weekly.
The standard of curative effect evaluation: effective: clinical symptoms and sign disappear, Electrocardioscopy recovers normal, and premature beat disappears, and paroxysmal supraventricular tachycardia, atrial fibrillation basic controlling or take place frequently transfers to accidental.Effective: clinical symptoms and sign are obviously improved, Electrocardioscopy takes a turn for the better, and premature beat reduces more than 50% before comparatively treating, and paroxysmal supraventricular tachycardia, atrial fibrillation Ventricular Rate reduced 50% or more more originally, persistent period comparatively treat before shorten or take place frequently transfer to multiple, or multiple transfer to accidental.Invalid: unchanged or increase the weight of before and after clinical symptoms and Electrocardioscopy medication.
Therapeutic outcome: therapeutic outcome is see table 1 and table 2.
Table 1 liang group treats Clinical efficacy comparison example (%) after 2 courses for the treatment of respectively
Group Number of cases Effective Take a turn for the better Invalid Total effective rate
Treatment group 48 36 12 0 48(100％)
Matched group 48 19 22 7 41(85.42％)
As can be seen from Table 1, treatment group treatment type of hyperactivity of fire caused by deficiency of YIN arrhythmia, relative to matched group, on therapeutic effect, has significant improvement.
To fully recover after table 2 liang group treats 2 courses for the treatment of respectively number and time comparative example (%)
Group Number of cases 1st week 2nd week 3rd week 4th week
Treatment group 36 7(14.6％) 20(41.7％) 30(62.5％) 36(75％)
Matched group 19 1(2.1％) 9(18.8％) 15(31.3％) 19(39.6％)
As can be seen from Table 2, relative to matched group, treatment group is better efficacy not only, treatment the course for the treatment of on significantly shorten, take effect faster.
Untoward reaction: the routine patient of matched group 48, in therapeutic process, feeling sick appears in 3 routine patients, xerostomia, inappetence, and bradycardia appears in 2 routine patients, and 1 routine blurred vision, 1 example occurs that Q-T extends, and does not all occur other untoward reaction such as hepatic and renal function injure., all there is not gastrointestinal upset, hepatic and renal function injure or other untoward reaction in the routine patient for the treatment of group 48.
Model case: Wu, male, 52 years old, because cardiopalmus, uncomfortable in chest, dizzy, agitation are admitted to hospital and are seen a doctor, arrhythmia (atrial fibrillation) is diagnosed as through electrocardiogram and 24h ambulatory electrocardiogram etc. inspections, then according to TCM pulse diagnosis, palpitation and uneasiness, fidgetyly sleeps less, have a dizzy spell, dryness of the mouth and throat, night sweat, the soreness of waist is rare soft; Red tongue, no fur, thready and rapid pulse, is diagnosed as type of hyperactivity of fire caused by deficiency of YIN arrhythmia further.Give cedilanid 0.4mg intramuscular injection, every day 3 times, take the capsule of Chinese medicine preparation embodiment 1 of the present invention simultaneously, every day 3 times, each 3, treat 2 weeks, clinical symptoms and sign disappear, and Electrocardioscopy recovers normal, and atrial fibrillation basic controlling is effective.
The above is only preferred embodiment of the present invention, and be not restriction the present invention being made to other form, any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the Equivalent embodiments of equivalent variations.But everyly do not depart from technical solution of the present invention content, any simple modification, equivalent variations and the remodeling done above embodiment according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.

Claims (9)

1. treat the ARR Chinese medicine of type of hyperactivity of fire caused by deficiency of YIN, it is characterized in that, comprise following raw medicinal material: Radix Laminariae, Herba Botrychii, bittersweet, Radix Cynanchi Paniculati, Folium seu radix uvariae microcarpae, Radix Indigoferae Szechuenensis, Fructus rubi tephrodis, Herba Coelogynes, Zibethum, Herbia Wedeliae, Flos Lupuli (Hops) and Herba Cassiopes selaginoidis.
2. Chinese medicine as claimed in claim 1, it is characterized in that, in described Chinese medicine, the ratio of weight and number of each raw medicinal material is: Radix Laminariae 30 ~ 40 parts, Herba Botrychii 25 ~ 35 parts, bittersweet 30 ~ 40 parts, Radix Cynanchi Paniculati 20 ~ 30 parts, Folium seu radix uvariae microcarpae 20 ~ 30 parts, Radix Indigoferae Szechuenensis 10 ~ 20 parts of Fructus rubi tephrodis 10 ~ 20 parts, Herba Coelogynes 15 ~ 25 parts, Zibethum 5 ~ 15 parts, Herbia Wedeliae 20 ~ 30 parts, Flos Lupuli (Hops) 20 ~ 35 parts and Herba Cassiopes selaginoidis 15 ~ 30 parts.
3. Chinese medicine as claimed in claim 1 or 2, it is characterized in that, in described Chinese medicine, the ratio of weight and number of each raw medicinal material is: Radix Laminariae 35 ~ 40 parts, Herba Botrychii 25 ~ 30 parts, bittersweet 30 ~ 35 parts, Radix Cynanchi Paniculati 20 ~ 25 parts, Folium seu radix uvariae microcarpae 25 ~ 30 parts, Radix Indigoferae Szechuenensis 10 ~ 15 parts of Fructus rubi tephrodis 15 ~ 20 parts, Herba Coelogynes 20 ~ 25 parts, Zibethum 5 ~ 10 parts, Herbia Wedeliae 25 ~ 30 parts, Flos Lupuli (Hops) 25 ~ 35 parts and Herba Cassiopes selaginoidis 20 ~ 30 parts.
4. the Chinese medicine as described in claims 1 to 3, is characterized in that, in described Chinese medicine, the ratio of weight and number of each raw medicinal material is: Radix Laminariae 38 parts, Herba Botrychii 26 parts, bittersweet 32 parts, Radix Cynanchi Paniculati 23 parts, Folium seu radix uvariae microcarpae 26 parts, Radix Indigoferae Szechuenensis 12 parts of Fructus rubi tephrodis 17 parts, Herba Coelogynes 22 parts, Zibethum 9 parts, Herbia Wedeliae 28 parts, Flos Lupuli (Hops) 26 parts and Herba Cassiopes selaginoidis 25 parts.
5. the Chinese medicine as described in claims 1 to 3, is characterized in that, in described Chinese medicine, the ratio of weight and number of each raw medicinal material is: Radix Laminariae 36 parts, Herba Botrychii 29 parts, bittersweet 35 parts, Radix Cynanchi Paniculati 21 parts, Folium seu radix uvariae microcarpae 27 parts, Radix Indigoferae Szechuenensis 14 parts of Fructus rubi tephrodis 15 parts, Herba Coelogynes 24 parts, Zibethum 6 parts, Herbia Wedeliae 26 parts, Flos Lupuli (Hops) 32 parts and Herba Cassiopes selaginoidis 22 parts.
6. the Chinese medicine as described in claim 1 to 5, is characterized in that, described form of Chinese drug is capsule, and its preparation method comprises the following steps:
The first step, by Radix Laminariae, Herba Botrychii, bittersweet, Radix Cynanchi Paniculati and Folium seu radix uvariae microcarpae mix in described ratio, add the water extraction volatile oil relative to 4 ~ 6 times, mixture, by the volatile oil beta-cyclodextrin inclusion compound obtained, the ratio of volatile oil and beta-schardinger dextrin-is 1:3 ~ 6, stir 65 minutes ~ 90 minutes, temperature 30 DEG C ~ 45 DEG C, obtains volatile oil clathrate compound, for subsequent use; Another when aqueous extract being concentrated into 60 DEG C relative density be the clear paste of 1.15 ~ 1.17;
Second step is Jiang Fructus rubi tephrodis, Herba Coelogynes and Zibethum mix in described ratio, add relative to mixture 5 ~ 8 times amount determining alcohol be 80% ~ 90% alcohol reflux 3 ~ 5 times, each 2 ~ 3 hours, filter, filtrate merges, reclaim ethanol, when being concentrated into 60 DEG C, relative density is the clear paste of 1.20 ~ 1.22, for subsequent use;
3rd step, will remain described raw medicinal material and mix in described ratio, add relative to mixture 8 ~ 10 times of water gagings, boil 6 ~ 8 hours, filter, and when being concentrated into 60 DEG C, relative density is the clear paste of 1.28 ~ 1.30;
4th step, mixed by the clear paste of the first step, second step, the 3rd step, 60 DEG C ~ 70 DEG C reduced vacuum dryings, get dry extract powder;
5th step, dried cream powder described in volatile oil clathrate compound described in the first step and the 4th step is fully mixed, subsequently relative to the mixture of volatile oil clathrate compound described in 100 weight portions and dried cream powder, add 5 ~ 7 weight portion carboxymethyl starch sodium, 5 ~ 50 weight starch mix homogeneously, adding 150 ~ 200 weight portion determining alcohols is 80% ~ 90% alcohol granulation, dry, granulate, subsequently relative to the mixture of volatile oil clathrate compound described in 100 weight portions and dried cream powder, add 3 ~ 5 weight portion magnesium stearate, then load in gelatine capsule.
7. the Chinese medicine as described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine is syrup, and its preparation method comprises the following steps:
The first step, by Radix Laminariae, Herba Botrychii, bittersweet, Radix Cynanchi Paniculati and Folium seu radix uvariae microcarpae mix in described ratio, adding relative to the determining alcohol of 4 ~ 6 times, mixture is the ethanol of 80% ~ 90%, heating and refluxing extraction 2 ~ 4 times, each reflux, extract, 2 hours ~ 3 hours, merge extractive liquid, with the centrifugal remove impurity of tube centrifuge, when the extracting solution after remove impurity being evaporated under the condition of 65 DEG C ~ 70 DEG C 60 DEG C, relative density is the medicinal liquid of 1.05 ~ 1.10, by dry with spray dryer for the concentrated solution after concentrated, be ground into 100 ~ 200 orders subsequently, obtain dry powder;
Second step, Jiang Fructus rubi tephrodis, Herba Coelogynes and Zibethum mix in described ratio, be ground into powder, with determining alcohol be the ethanol of 85% ~ 95% as solvent, flood 48 hours ~ 72 hours, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being concentrated into 65 DEG C, relative density is the mastic of 1.25 ~ 1.27, dry with spray dryer, is ground into 150 ~ 200 orders subsequently, obtain dry powder, the quality of the ethanol added is 3 ~ 5 times of second step mixture quality;
3rd step, surplus stock medical material is mixed in described ratio, add relative to mixture 4 ~ 6 times amount determining alcohol be 70% ~ 80% alcohol reflux 2 ~ 4 times, each 1 hour ~ 3 hours, filter, filtrate merges, reclaim ethanol, when being concentrated into 60 DEG C, relative density is the mastic of 1.20 ~ 1.22, in 55 DEG C ~ 65 DEG C reduced vacuum dryings, obtains dry powder;
4th step, by the dry powder blend that the first step obtains to the 3rd step, add the water dissolution relative to mixture quality 3 ~ 5 times, by 40% sodium hydroxide solution adjust ph to 7.0, add correctives sucrose, antiseptic mix homogeneously subsequently, obtain syrup, the correctives added, antiseptic and the content in medicine thereof: sucrose 30 ~ 60%, Pyrusussuriensis acids antiseptic are if potassium sorbate 0.1 ~ 0.3%, paraben preservative are as ethyl hydroxybenzoate 0.01 ~ 0.05%.
8. a preparation method for the Chinese medicine preparation described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine is capsule, and its preparation method comprises the following steps:
The first step, by Radix Laminariae, Herba Botrychii, bittersweet, Radix Cynanchi Paniculati and Folium seu radix uvariae microcarpae mix in described ratio, add the water extraction volatile oil relative to 4 ~ 6 times, mixture, by the volatile oil beta-cyclodextrin inclusion compound obtained, the ratio of volatile oil and beta-schardinger dextrin-is 1:3 ~ 6, stir 60 minutes ~ 90 minutes, temperature 30 DEG C ~ 50 DEG C, obtains volatile oil clathrate compound, for subsequent use; Another when aqueous extract being concentrated into 60 DEG C relative density be the clear paste of 1.15 ~ 1.17;
Second step is Jiang Fructus rubi tephrodis, Herba Coelogynes and Zibethum mix in described ratio, add relative to mixture 5 ~ 8 times amount determining alcohol be 75% ~ 90% alcohol reflux 3 ~ 5 times, each 2 ~ 3 hours, filter, filtrate merges, reclaim ethanol, when being concentrated into 60 DEG C, relative density is the clear paste of 1.20 ~ 1.22, for subsequent use;
3rd step, will remain described raw medicinal material and mix in described ratio, add relative to mixture 8 ~ 10 times of water gagings, boil 6 ~ 8 hours, filter, and when being concentrated into 60 DEG C, relative density is the clear paste of 1.28 ~ 1.30;
4th step, mixed by the clear paste of the first step, second step, the 3rd step, 60 DEG C ~ 70 DEG C reduced vacuum dryings, get dry extract powder;
5th step, dried cream powder described in volatile oil clathrate compound described in the first step and the 4th step is fully mixed, subsequently relative to the mixture of volatile oil clathrate compound described in 100 weight portions and dried cream powder, add 5 ~ 7 weight portion carboxymethyl starch sodium, 5 ~ 50 weight starch mix homogeneously, adding 150 ~ 200 weight portion determining alcohols is 80% ~ 90% alcohol granulation, dry, granulate, subsequently relative to the mixture of volatile oil clathrate compound described in 100 weight portions and dried cream powder, add 3 ~ 5 weight portion magnesium stearate, then load in gelatine capsule.
9. a preparation method for the Chinese medicine preparation described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine is syrup, and its preparation method comprises the following steps:
The first step, by Radix Laminariae, Herba Botrychii, bittersweet, Radix Cynanchi Paniculati and Folium seu radix uvariae microcarpae mix in described ratio, adding relative to the determining alcohol of 4 ~ 6 times, mixture is the ethanol of 80% ~ 90%, heating and refluxing extraction 2 ~ 4 times, each reflux, extract, 2 hours ~ 3 hours, merge extractive liquid, with the centrifugal remove impurity of tube centrifuge, when the extracting solution after remove impurity being evaporated under the condition of 60 DEG C ~ 70 DEG C 60 DEG C, relative density is the medicinal liquid of 1.05 ~ 1.10, by dry with spray dryer for the concentrated solution after concentrated, be ground into 100 ~ 200 orders subsequently, obtain dry powder;
Second step, Jiang Fructus rubi tephrodis, Herba Coelogynes and Zibethum mix in described ratio, be ground into powder, with determining alcohol be the ethanol of 85% ~ 95% as solvent, flood 48 hours ~ 72 hours, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being concentrated into 60 DEG C, relative density is the mastic of 1.25 ~ 1.27, dry with spray dryer, is ground into 150 ~ 200 orders subsequently, obtain dry powder, the quality of the ethanol added is 3 ~ 5 times of second step mixture quality;
3rd step, surplus stock medical material is mixed in described ratio, add relative to mixture 4 ~ 6 times amount determining alcohol be 70% ~ 80% alcohol reflux 2 ~ 4 times, each 1 hour ~ 3 hours, filter, filtrate merges, reclaim ethanol, when being concentrated into 60 DEG C, relative density is the mastic of 1.20 ~ 1.22, in 55 DEG C ~ 65 DEG C reduced vacuum dryings, obtains dry powder;
4th step, by the dry powder blend that the first step obtains to the 3rd step, add the water dissolution relative to mixture quality 3 ~ 5 times, by 40% sodium hydroxide solution adjust ph to 7.0, add correctives sucrose, antiseptic mix homogeneously subsequently, obtain syrup, the correctives added, antiseptic and the content in medicine thereof: sucrose 30 ~ 60%, Pyrusussuriensis acids antiseptic are if potassium sorbate 0.1 ~ 0.3%, paraben preservative are as ethyl hydroxybenzoate 0.01 ~ 0.05%.
CN201610052743.2A 2016-01-27 2016-01-27 Traditional Chinese medicine for treating Yin-deficiency and fire-excess type arrhythmia and preparation method Pending CN105434885A (en)

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