CN107412679A - Detoxifying health-care product and its preparation method and application - Google Patents

Detoxifying health-care product and its preparation method and application Download PDF

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Publication number
CN107412679A
CN107412679A CN201710709534.5A CN201710709534A CN107412679A CN 107412679 A CN107412679 A CN 107412679A CN 201710709534 A CN201710709534 A CN 201710709534A CN 107412679 A CN107412679 A CN 107412679A
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parts
care
raw
detoxifying health
health
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丁群
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Beijing Tzu Chi Ming Medical Research Institute
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Beijing Tzu Chi Ming Medical Research Institute
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/906Zingiberaceae (Ginger family)
    • A61K36/9066Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/32Bones; Osteocytes; Osteoblasts; Tendons; Tenocytes; Teeth; Odontoblasts; Cartilage; Chondrocytes; Synovial membrane
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56Materials from animals other than mammals
    • A61K35/60Fish, e.g. seahorses; Fish eggs
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06Fungi, e.g. yeasts
    • A61K36/07Basidiomycota, e.g. Cryptococcus
    • A61K36/074Ganoderma
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/16Ginkgophyta, e.g. Ginkgoaceae (Ginkgo family)
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    • A61K36/18Magnoliophyta (angiosperms)
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    • A61K36/484Glycyrrhiza (licorice)
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    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH

Abstract

The present invention relates to medical health product technical field, is related to a kind of detoxifying health-care product and its preparation method and application.The detoxifying health-care product of the present invention, including radix glycyrrhizae, ginkgo leaf, rhizoma alismatis, oriental wormwood, turmeric, lotus leaf, the fruit of Chinese wolfberry, peach kernel, dark plum, spina date seed, ginseng, pilose antler, hippocampus, ganoderma lucidum, Ligusticum wallichii, the bighead atractylodes rhizome, sealwort, radix bupleuri, the root of herbaceous peony, rascal, Radix Angelicae Sinensis, corn stigma, root tuber of aromatic turmeric and Herba Lycopi.The detoxifying health-care product of the present invention, unnecessary side effect will not be brought to body, safe to use, convenient and quick, for excluding the toxin in vivo in the dirty insidious and blood of each internal organs, regulation recovers total balance of the body, enhancing body resistivity has positive role.

Description

Detoxifying health-care product and its preparation method and application
Technical field
The present invention relates to medical health product technical field, more particularly to a kind of detoxifying health-care product and preparation method thereof and should With.
Background technology
With the quickening of modernization step, under the overall situation of pollution getting worse, the invasion of " modern civilization diseases " and wound Evil, increasingly affects the work and life of people;The toxin accumulated in people's body accordingly increases, and is born to caused by human body It is increasing.
Human toxin, it is rubbish unnecessary in vivo in fact, mainly includes two major classes:" external poison " and " interior raw poison ". " external poison " mainly includes what atmosphere pollution, vehicle exhaust, industrial waste gas, chemicals, junk food etc. were brought to human body The deposition in human body such as toxic side effect and pathogenic microorganism;" interior raw poison " mainly includes producing in normal metabolic processes Metabolic waste, delay of the poison in human body caused by enteral stool and glycolipid fat protein metabolism disorder.Only by this A little toxin are discharged in time, can just be kept fit.Various toxin, waste retain can cause metabolic disorder in vivo, hinder gas Blood normal operation, destroy internal organs function and internal organs it is dirty between it is mutually coordinated.In addition, a large amount of accumulation of vivotoxin can also trigger The diseases such as fever, tumour, seriously endanger human health.
Various toxin expelling methods or toxins eliminating agent be also there is some drawbacks in the market, as some curative effects are also possible that but secondary Effect is big, may cause new hidden danger, can also produce dependence;Some DeGrains, curative effect are not notable enough;Some prices are held high Expensive, large-scale production is restricted.So as to, research and develop a kind of drug action it is good, without adverse reaction and cost it is cheap Detoxifying health-care product, have important practical significance.
In view of this, it is special to propose the present invention.
The content of the invention
The first object of the present invention is to provide a kind of detoxifying health-care product, using medicinal and edible plant as primary raw material, there is pin To the reasonable compatibility of property, the toxin in body can be effectively excluded, and have no toxic side effect.
The second object of the present invention is to provide a kind of preparation method of detoxifying health-care product, and this method flow is simple, operation Conveniently, the effect of can giving full play to each raw material, the active ingredient of raw material has obtained more preferable enrichment, and product stability is good.
The third object of the present invention is that providing a kind of detoxifying health-care product is preparing with dispel stool, expelling intestinal toxin, strengthening the spleen and stomach And/or the application in the medicine of clearing lung-heat expectoration effect, body immunity can be effectively improved, prevents the generation of various diseases.
In order to realize the above-mentioned purpose of the present invention, spy uses following technical scheme:
According to an aspect of the present invention, the present invention provides a kind of detoxifying health-care product, mainly by the raw material of following parts by weight It is made:
40~80 parts of radix glycyrrhizae, 40~80 parts of ginkgo leaf, 5~15 parts of rhizoma alismatis, 5~12 parts of oriental wormwood, 6~16 parts of turmeric, lotus leaf 40~80 parts, 12~24 parts of the fruit of Chinese wolfberry, 10~18 parts of peach kernel, 15~30 parts of dark plum, 15~30 parts of spina date seed, ginseng 10~25 Part, 5~15 parts of pilose antler, 5~15 parts of hippocampus, 10~18 parts of ganoderma lucidum, 5~15 parts of Ligusticum wallichii, 5~15 parts of the bighead atractylodes rhizome, 2~12 parts of sealwort, 2~12 parts of radix bupleuri, 2~12 parts of the root of herbaceous peony, 2~12 parts of rascal, 2~12 parts of Radix Angelicae Sinensis, 5~15 parts of corn stigma, 5~15 parts of root tuber of aromatic turmeric and pool It is blue 5~15 parts.
As further preferred technical scheme, the detoxifying health-care product are mainly made up of the raw material of following parts by weight:
50~70 parts of radix glycyrrhizae, 50~70 parts of ginkgo leaf, 8~10 parts of rhizoma alismatis, 7~9 parts of oriental wormwood, 10~12 parts of turmeric, lotus leaf 50~70 parts, 18~20 parts of the fruit of Chinese wolfberry, 13~15 parts of peach kernel, 20~25 parts of dark plum, 20~25 parts of spina date seed, ginseng 15~20 Part, 8~10 parts of pilose antler, 8~10 parts of hippocampus, 12~15 parts of ganoderma lucidum, 8~10 parts of Ligusticum wallichii, 8~10 parts of the bighead atractylodes rhizome, 5~8 parts of sealwort, bavin 5~8 parts recklessly, 5~8 parts of the root of herbaceous peony, 5~8 parts of rascal, 5~8 parts of Radix Angelicae Sinensis, 8~10 parts of corn stigma, 8~10 parts of root tuber of aromatic turmeric and Herba Lycopi 8~ 10 parts.
As further preferred technical scheme, the detoxifying health-care product are mainly made up of the raw material of following parts by weight:
55~65 parts of radix glycyrrhizae, 55~65 parts of ginkgo leaf, 8.5~9.5 parts of rhizoma alismatis, 7.5~8.5 parts of oriental wormwood, turmeric 10.5~ 11.5 parts, 55~65 parts of lotus leaf, 18.5~19.5 parts of the fruit of Chinese wolfberry, 13.5~14.5 parts of peach kernel, 21~23 parts of dark plum, spina date seed 21 ~23 parts, 16~18 parts of ginseng, 8.5~9.5 parts of pilose antler, 8.5~9.5 parts of hippocampus, 13~14 parts of ganoderma lucidum, Ligusticum wallichii 8.5~9.5 Part, 8.5~9.5 parts of the bighead atractylodes rhizome, 6~7 parts of sealwort, 6~7 parts of radix bupleuri, 6~7 parts of the root of herbaceous peony, 6~7 parts of rascal, 6~7 parts of Radix Angelicae Sinensis, corn 8.5~9.5 parts of 8.5~9.5 parts of palpus, 8.5~9.5 parts of root tuber of aromatic turmeric and Herba Lycopi.
As further preferred technical scheme, the formulation of the detoxifying health-care product is oral formulations.
As further preferred technical scheme, the formulations of the detoxifying health-care product is tablet, capsule, granule, pill, Pulvis or oral liquid.
According to another aspect of the present invention, the present invention also provides the preparation side of the detoxifying health-care product described in more than one Method, it the described method comprises the following steps:
Each raw material is crushed respectively, alcohol extracting and drying, obtain each extract;
Each extract is mixed according to formula rate, the detoxifying health-care product are made.
As further preferred technical scheme, in described pulverising step, raw material is dried at 90 DEG C~115 DEG C first To constant weight, then crushed to obtain powdered raw material with mortar;
Preferably, the temperature of drying is 100 DEG C~105 DEG C;
Preferably, the granularity of crushing is the mesh of 60 mesh~80.
As further preferred technical scheme, in described alcohol extracting step, the raw material after crushing is weighed first, is placed on In extraction element, then add volumetric concentration and be 75%~90% ethanol solution heating and refluxing extraction 1~3 time, backflow every time carries The time taken is 1~3 hour, and reflux temperature is 85 DEG C~98 DEG C, and the quality of raw material and the volume ratio of ethanol solution are 1:10~ 30;
Preferably, the extraction element is apparatus,Soxhlet's;
Preferably, the volumetric concentration of the ethanol solution is 80%~85%;
Preferably, the time of each refluxing extraction is 2~2.5 hours, and reflux temperature is 88 DEG C~90 DEG C, the quality of raw material Volume ratio with ethanol solution is 1:20~22.
As further preferred technical scheme, in described drying steps, ethanol is reclaimed using vacuum distillation mode first, Mucus is obtained, then mucus is dried, obtains extract;
Preferably, dry temperature is 85 DEG C~105 DEG C.
According to another aspect of the present invention, the detoxifying health-care product that the present invention is also provided described in more than one have in preparation Dispel stool, expelling intestinal toxin, strengthening the spleen and stomach and/or clearing lung-heat expectoration effect medicine in application.
Compared with prior art, the beneficial effects of the present invention are:
1st, detoxifying health-care product provided by the invention, targetedly reasonable compatibility, with radix glycyrrhizae, ginkgo leaf, lotus leaf, the fruit of Chinese wolfberry It is raw material Deng medicinal and edible plant, each raw material components are scientifically arranged in pairs or groups, and are influenced each other between each component, obtain synergy, battalion Support it is with strong points, for people provide it is a kind of it is natural, safely and effectively, have no toxic side effect, the toxin expelling with significant toxin expelling curative effect Health products.
Each medicinal and edible plant raw material of well-chosen of the present invention, each raw material cooperate, and not only toxin expelling curative effect is obvious, will not Unnecessary side effect is brought to body, while there are three zones that are clear, adjusting, mend, that is, it is clear in arranging, adjust in clear, mended in tune;Clothes Human body is enabled to reach through effect logical, that gas is logical, magic, blood is logical and just logical after;With broad spectrum activity, high efficiency, agility, Safe without toxic side effect, content of beary metal zero, it is moderate the advantages of.
2nd, the preparation method of detoxifying health-care product provided by the invention, flow is simple, easy to operate, can give full play to each original The effect of material, effective nutritional ingredient of each raw material have obtained more preferable enrichment, have reduced the invalid components in medicine, and nutrition is rich Richness, mouthfeel is excellent, safe without toxic side effect, and product stability is good, and for excluding vivotoxin, regulation recovers total balance of the body, increases Strong resistance has positive role, is easy to industrialized production.
3rd, detoxifying health-care product provided by the invention are applied and prepared with dispel stool, expelling intestinal toxin, strengthening the spleen and stomach and/or clearing lung-heat In the medicine of expectoration effect, unnecessary side effect will not be brought to body, instant is again quick, for excluding each internal organs in vivo Toxin in dirty insidious and blood, regulation recovers total balance of the body, enhancing body resistivity has positive role.
Embodiment
Embodiment of the present invention is described in detail below in conjunction with embodiment and embodiment, but this area skill Art personnel will be understood that following embodiments and embodiment are merely to illustrate the present invention, and be not construed as the model of the limitation present invention Enclose.Based on the embodiment in the present invention, what those of ordinary skill in the art were obtained under the premise of creative work is not made Every other embodiment, belongs to the scope of protection of the invention.Unreceipted actual conditions person, builds according to normal condition or manufacturer The condition of view is carried out.Agents useful for same or the unreceipted production firm person of instrument, it is the conventional production that can be obtained by commercially available purchase Product.
In a first aspect, present embodiment provides a kind of detoxifying health-care product, mainly it is made up of the raw material of following parts by weight:
40~80 parts of radix glycyrrhizae, 40~80 parts of ginkgo leaf, 5~15 parts of rhizoma alismatis, 5~12 parts of oriental wormwood, 6~16 parts of turmeric, lotus leaf 40~80 parts, 12~24 parts of the fruit of Chinese wolfberry, 10~18 parts of peach kernel, 15~30 parts of dark plum, 15~30 parts of spina date seed, ginseng 10~25 Part, 5~15 parts of pilose antler, 5~15 parts of hippocampus, 10~18 parts of ganoderma lucidum, 5~15 parts of Ligusticum wallichii, 5~15 parts of the bighead atractylodes rhizome, 2~12 parts of sealwort, 2~12 parts of radix bupleuri, 2~12 parts of the root of herbaceous peony, 2~12 parts of rascal, 2~12 parts of Radix Angelicae Sinensis, 5~15 parts of corn stigma, 5~15 parts of root tuber of aromatic turmeric and pool It is blue 5~15 parts.
In the present invention, the effect of each raw material and effect is as follows:
Radix glycyrrhizae:It is mild-natured, sweet, have invigorating middle warmer and replenishing QI, relieving spasm to stop pain, moisten the lung and relieve the cough, purging intense heat and detonicating, the work(of coordinating the drug actions of a prescription Effect.Meanwhile radix glycyrrhizae energy emergency, moreover it is possible to play the mediation effect to all medicines, most of Traditional Chinese medicinal prescription has all been arranged in pairs or groups radix glycyrrhizae, so-called " grass of ten side nine ", especially because its sweet taste can cover the toil taste of other medicinal materials, patient is set to be easier to receive.In the present invention, Count in parts by weight, the typical but non-limiting content of radix glycyrrhizae is:40 parts, 45 parts, 50 parts, 55 parts, 60 parts, 65 parts, 70 parts, 75 Part or 80 parts.
Ginkgo leaf:It is sweet, bitter, puckery, it is mild-natured, have promoting blood circulation and removing blood stasis, remove obstruction in channels to relieve pain, astringe the lung and relieving asthma, the effect of changing turbid lipid-loweringing; Cholesterol levels in blood of human body can also be reduced, artery sclerosis is prevented, also has improvement result to myocardial ischemia.In the present invention, Count in parts by weight, the typical but non-limiting content of ginkgo leaf is:40 parts, 45 parts, 50 parts, 55 parts, 60 parts, 65 parts, 70 parts, 75 parts or 80 parts.
Rhizoma alismatis:It is sweet, it is light, it is cold in nature, return kidney, bladder warp;With clearing damp and promoting diuresis;Expel the heat-evil the effect for the treatment of stranguria.In addition, also help In the transhipment and excretion of cholesterol, the absorption of cholesterol is disturbed, plays a part of reducing blood lipid;Its rhizoma alismatis element contained can reduce outer Property hypercholesterolia in source enters in vivo, there is obvious effect for reducing fat, antihypertensive effect.In the present invention, count in parts by weight, rhizoma alismatis allusion quotation Type but nonrestrictive content is:5 parts, 6 parts, 7 parts, 8 parts, 9 parts, 10 parts, 11 parts, 12 parts, 13 parts, 14 parts or 15 parts.
Oriental wormwood:It is bitter, pungent, it is slightly cold, returns spleen, stomach, liver, gallbladder channel;Tonka-bean in oriental wormwood is known as Lipid-lowering activities, can lower serum courage Sterol, mitigating aortosclerosis has liver function protecting, has the effect such as reducing blood lipid, decompression, coronary dilatation.In the present invention, by weight Number meter is measured, the typical but non-limiting content of oriental wormwood is:5 parts, 6 parts, 7 parts, 8 parts, 9 parts, 10 parts, 11 parts or 12 parts.
Turmeric:Acrid flavour, hardship, it is warm-natured;Returns spleen, Liver Channel;Blood-breaking, it is inducing meastruation to relieve menalgia;Twinged available for chest side of body, amenorrhoea, disease Lump in the abdomen, rheumatism shoulder arm pain, tumbling and swelling;Also there is the effect such as reducing blood lipid, antitumor, anti-inflammatory.In the present invention, in parts by weight Meter, the typical but non-limiting content of turmeric are:6 parts, 7 parts, 8 parts, 9 parts, 10 parts, 11 parts, 12 parts, 13 parts, 14 parts, 15 parts or 16 parts.
Lotus leaf:Bitter, it is pungent micro-puckery, cool in nature cold;Cure mainly hot summer weather polydipsia, dizziness of having a headache, oedema, deficiency of food abdominal distension, rush down dysentery, in vain Band, prolapse of the anus, spit blood, bleeding from five sense organs or subcutaneous tissue, spitting of blood, have blood in stool, uterine bleeding, post partum longtime lochia, traumatic blood stasis;Disinfected with toxin expelling, hypertension and hyperlipemia, Raise the effect such as purging intense heat.In the present invention, count in parts by weight, the typical but non-limiting content of lotus leaf is:40 parts, 45 parts, 50 Part, 55 parts, 60 parts, 65 parts, 70 parts, 75 parts or 80 parts.
The fruit of Chinese wolfberry:It is mild-natured, it is sweet;Return liver and kidney channel;With nourishing liver and kidney, the effect of benefiting shrewd head;For consumption consumptive loss, Soreness of waist and knee joint, dizziness and tinnitus, impotence and seminal emission, Heat Diabetes, blood deficiency chlorosis, blurred vision;There is facilitation to hematopoiesis function, also There are anti-aging, anti-mutation, antitumor, anti-fatty liver and the effect such as hypoglycemic.In the present invention, count in parts by weight, fruit of Chinese wolfberry allusion quotation Type but nonrestrictive content is:12 parts, 13 parts, 14 parts, 15 parts, 16 parts, 17 parts, 18 parts, 19 parts, 20 parts, 21 parts, 22 parts, 23 parts or 24 parts.
Peach kernel:Bitter, it is mild-natured.Return hand, meridian of Foot-JUE YIN.The effect of with the silt of blood-breaking row, moisturize laxation;Stored for pyreticosis Blood, traumatic injury, blood stasis and swelling pain.In the present invention, count in parts by weight, the typical but non-limiting content of peach kernel is:10 parts, 11 Part, 12 parts, 13 parts, 14 parts, 15 parts, 16 parts, 17 parts or 18 parts.
Dark plum:It is sour, puckery, it is mild-natured;Return liver, spleen, lung, large intestine channel;For chronic cough of deficiency lung, abnormal heat polydipsia, chronic malaria, chronic diarrhea, Dysentery, have blood in stool, hematuria;Metrorrhagia, ascariasis of biliary tract stomachache, vomiting, hookworm disease.Can protect stomach, eliminate constipation, improve a poor appetite, anti-aging, Purify the blood and relieve the effect of alcohol, there is the effect of prevention disease and dispelling fatigue.In the present invention, count in parts by weight, dark plum is typical but unrestricted The content of property is:15 parts, 16 parts, 17 parts, 18 parts, 19 parts, 20 parts, 21 parts, 22 parts, 23 parts, 24 parts, 25 parts, 26 parts, 27 parts, 28 parts, 29 parts or 30 parts.
Spina date seed:It is sweet, it is mild-natured;Thoughts of returning home warp, the spleen channel, Liver Channel, gallbladder channel;With antitoxic heart-soothing and sedative, nourishing the liver, the effect of arrest sweating; Available for antitoxic heart-soothing and sedative, nourishing the liver, arrest sweating.In the present invention, count in parts by weight, the typical but non-limiting content of spina date seed is: 15 parts, 16 parts, 17 parts, 18 parts, 19 parts, 20 parts, 21 parts, 22 parts, 23 parts, 24 parts, 25 parts, 26 parts, 27 parts, 28 parts, 29 parts or 30 parts.
Ginseng:Slightly warm in nature, sweet, slight bitter;Returns spleen, lung, the heart, kidney channel;With reinforcing vital energy, veins takes off admittedly, reinforce the spleen to benefit the lung, Promote the production of body fluid blood-nourishing, the effect of tranquilize the mind and promote the intelligence;To be taken off for physically weak, cold weak pulse of limb, spleen eating less, the deficiency syndrome of the lung is breathed with cough, injury thirst, interior heat Quench one's thirst, deficiency of qi and blood, prolonged illness is empty to win, insomnia of palpitating with fear, impotence Gong Leng.In the present invention, count in parts by weight, ginseng is typical but non-limit The content of property processed is:10 parts, 11 parts, 12 parts, 13 parts, 14 parts, 15 parts, 16 parts, 17 parts, 18 parts, 19 parts, 20 parts, 21 parts, 22 Part, 23 parts, 24 parts or 25 parts.
Pilose antler:It is sweet, salty, it is warm-natured;Return kidney, Liver Channel;With invigorating kidney yang, marrow is mended, strengthening the bones and muscles, adjusts punching to appoint, torr sore poison Effect;Available for kidney deficiency, dizziness, deafness, mesh be dark, impotence, involuntary emission, uterus cold infertile, god are tired, chilly, spinal column crymodynia, muscles and bones impotence Soft, cloudy subcutaneous ulcer is not held back and the diseases such as prolonged illness is deficient.It can increase defence capability of the body to the external world, adjust internal immunologic balance and keep away Exempt from disease and occur and promote wound healing, sick body rehabilitation, so as to play a part of strengthening body, resistance aging.In the present invention, press Parts by weight meter, the typical but non-limiting content of pilose antler are:5 parts, 6 parts, 7 parts, 8 parts, 9 parts, 10 parts, 11 parts, 12 parts, 13 Part, 14 parts or 15 parts.
Hippocampus:It is warm-natured, it is sweet;With tonifying kidney and strengthening yang, warm promoting blood circulation, tranquilizing and allaying excitement, mass dissipating and swelling eliminating, relaxing tendons and activating collaterals, cough-relieving The effect of relievining asthma;Its is warm-natured supporing yang, energy warming meridian, has promoting blood circulation effect again, cures mainly kidney deficiency, impotence, the enuresis.In the present invention, press Parts by weight meter, the typical but non-limiting content of hippocampus are:5 parts, 6 parts, 7 parts, 8 parts, 9 parts, 10 parts, 11 parts, 12 parts, 13 Part, 14 parts or 15 parts.
Ganoderma lucidum:It is warm-natured, it is lightly seasoned;With invigorating qi for tranquilization, it is relieving cough and asthma the effect of, for dizziness egersis, palpitation, consumptive disease Cough and asthma;Its is sweet mild-natured, enters the heart channel of Hang-Shaoyin, can bushing blood, invigorating heart gas, tranquilizing mind, available for control insufficiency of vital energy and blood, the mind is lost caused by supporting Have no peace of mind, have a sleepless night, palpitating with fear, dreaminess, the disease such as forgetful, the tired tired, deficiency of food of god of body;Also there is protecting liver and detoxication, improve cardiovascular system Deng effect.In the present invention, count in parts by weight, the typical but non-limiting content of ganoderma lucidum is:5 parts, 6 parts, 7 parts, 8 parts, 9 parts, 10 parts, 11 parts, 12 parts, 13 parts, 14 parts, 15 parts 16 parts, 17 parts or 18 parts.
Ligusticum wallichii:Acrid flavour, it is warm-natured;Return liver, courage, pericardium channel;With blood-activating and qi-promoting, the effect of wind-expelling pain-stopping;Available for pacifying Nerve, positive head wind headache, abdominal mass stomachache, chest side of body shouting pain, tumbling and swelling, headache, arthralgia pain due to rheumatism.In the present invention, in parts by weight Meter, the typical but non-limiting content of Ligusticum wallichii are:5 parts, 6 parts, 7 parts, 8 parts, 9 parts, 10 parts, 11 parts, 12 parts, 13 parts, 14 parts or 15 parts.
The bighead atractylodes rhizome:It is bitter, sweet, it is warm-natured;Returns spleen, stomach;With strengthening the spleen and replenishing qi, eliminate dampness and have diuretic effect, hidroschesis, it is antiabortive the effect of;Can For diseases such as spleen eating less, abdominal distention diarrhea, phlegm retention anti-dazzle nervous, oedema, spontaneous perspiration, fetal irritabilities.In the present invention, count in parts by weight, The typical but non-limiting content of the bighead atractylodes rhizome is:5 parts, 6 parts, 7 parts, 8 parts, 9 parts, 10 parts, 11 parts, 12 parts, 13 parts, 14 parts or 15 Part.
Sealwort:It is mild-natured, it is sweet;Returns spleen, lung, kidney channel;With boosting qi and nourishing yin, invigorating the spleen, moistening lung, the effect of kidney-nourishing;For spleen Stomach Qi deficiency, fatigue and asthenia, deficiency of stomach-Yin, dry deficiency of food, deficiency syndrome of the lung cough caused by dryness, overstrain cough hemoptysis, asthenia of essence and blood, soreness and weakness of waist and knees, beard and hair are early In vain, Heat Diabetes.In the present invention, count in parts by weight, the typical but non-limiting content of sealwort is:2 parts, 3 parts, 4 parts, 5 parts, 6 parts, 7 parts, 8 parts, 9 parts, 10 parts, 11 parts or 12 parts.
Radix bupleuri:Bitter, pungent, cold nature;Return liver, courage, spleen, stomach, tri-jiao channel;Brought down a fever with evacuation, soothing liver-qi stagnation, rising Yang is lifted Sunken function.In the present invention, count in parts by weight, the typical but non-limiting content of radix bupleuri is:2 parts, 3 parts, 4 parts, 5 parts, 6 Part, 7 parts, 8 parts, 9 parts, 10 parts, 11 parts or 12 parts.
The root of herbaceous peony:Bitter, acid;Cold nature;Return liver, the spleen channel;With soft liver analgesic, nourishing blood for regulating menstruation, astringing YIN to stop sweating, suppressing liver-YANG Function.In the present invention, count in parts by weight, the typical but non-limiting content of the root of herbaceous peony is:2 parts, 3 parts, 4 parts, 5 parts, 6 parts, 7 Part, 8 parts, 9 parts, 10 parts, 11 parts or 12 parts.
Rascal:It is bitter, pungent, it is warm-natured;Return liver, courage, stomach;With the function that soothing the liver relieving stagnant Qi, disperse accumulationsization are stagnant.In the present invention, Count in parts by weight, the typical but non-limiting content of rascal is:2 parts, 3 parts, 4 parts, 5 parts, 6 parts, 7 parts, 8 parts, 9 parts, 10 parts, 11 parts or 12 parts.
Radix Angelicae Sinensis:It is sweet, pungent;It is warm-natured, Return liver, the heart, the spleen channel;With enrich blood, invigorate blood circulation, menstruation regulating, analgesic, ease constipation function.This In invention, count in parts by weight, the typical but non-limiting content of Radix Angelicae Sinensis is:2 parts, 3 parts, 4 parts, 5 parts, 6 parts, 7 parts, 8 parts, 9 Part, 10 parts, 11 parts or 12 parts.
Corn stigma:It is sweet, light, it is mild-natured;Return bladder, liver, gallbladder channel;Main oedema, dribbling urination, jaundice, cholecystitis, courage knot Stone, hypertension, diabetes, alactation.Acted on reducing blood lipid, diuresis, decompression, cholagogic etc..In the present invention, in parts by weight Meter, the typical but non-limiting content of corn stigma are:5 parts, 6 parts, 7 parts, 8 parts, 9 parts, 10 parts, 11 parts, 12 parts, 13 parts, 14 parts Or 15 parts.
Root tuber of aromatic turmeric:Acrid flavour, hardship, it is cool in nature;Enter the heart, lung, Liver Channel;With promoting qi circulation and removing obstruction in the collateral, the effect of cool blood broken stasis of blood, available for controlling chest The all pains of abdomen side of body rib, the mistake heart is demented, pyreticosis coma, spits blood, bleeding from five sense organs or subcutaneous tissue, hematuria, blood strangury, women's vicarious menstruation, the disease such as jaundice.In the present invention, Count in parts by weight, the typical but non-limiting content of root tuber of aromatic turmeric is:5 parts, 6 parts, 7 parts, 8 parts, 9 parts, 10 parts, 11 parts, 12 part 13 Part, 14 parts or 15 parts.
Herba Lycopi:Bitter, pungent, slightly warm in nature;Return liver, the spleen channel;With promoting blood circulation, the effect of inducing diuresis for removing edema;Available for controlling blood Stasis of blood Amenorrhea, stimulates the menstrual flow, abdominal mass, postpartum stasis of blood, body and face edema, injury from falling down, metal-inflicted wound, sore and toxic, oedema, the disease such as ascites. In the present invention, count in parts by weight, the typical but non-limiting content of Herba Lycopi is:5 parts, 6 parts, 7 parts, 8 parts, 9 parts, 10 parts, 11 Part, 12 parts 13 parts, 14 parts or 15 parts.
The detoxifying health-care product that present embodiment provides, targetedly reasonable compatibility, with radix glycyrrhizae, ginkgo leaf, lotus leaf, matrimony vine The medicinal and edible plants such as son are raw material, and each raw material components are scientifically arranged in pairs or groups, influenced each other between each component, obtain synergy, For people provide it is a kind of it is natural, safely and effectively, the detoxifying health-care product that have no toxic side effect, there is significant toxin expelling curative effect.The row Malicious health products will not bring unnecessary side effect to body, while have three zones that are clear, adjusting, mend, that is, clear in arranging, in clear Adjust, mended in tune;Human body is enabled to reach through effect logical, that gas is logical, magic, blood is logical and just logical after taking;With broad spectrum activity, height The advantages that effect property, agility.
In addition, when above-mentioned detoxifying health-care product raw material is using above-mentioned component composition and proportioning, described detoxifying health-care product Influencing each other between middle various composition, complements each other, and synergy more preferably, can provide comprehensive nutritional support for patient, The health value of above-mentioned medicinal and edible plant raw material can more be embodied.
Further, the detoxifying health-care product are mainly made up of the raw material of following parts by weight:
50~70 parts of radix glycyrrhizae, 50~70 parts of ginkgo leaf, 8~10 parts of rhizoma alismatis, 7~9 parts of oriental wormwood, 10~12 parts of turmeric, lotus leaf 50~70 parts, 18~20 parts of the fruit of Chinese wolfberry, 13~15 parts of peach kernel, 20~25 parts of dark plum, 20~25 parts of spina date seed, ginseng 15~20 Part, 8~10 parts of pilose antler, 8~10 parts of hippocampus, 12~15 parts of ganoderma lucidum, 8~10 parts of Ligusticum wallichii, 8~10 parts of the bighead atractylodes rhizome, 5~8 parts of sealwort, bavin 5~8 parts recklessly, 5~8 parts of the root of herbaceous peony, 5~8 parts of rascal, 5~8 parts of Radix Angelicae Sinensis, 8~10 parts of corn stigma, 8~10 parts of root tuber of aromatic turmeric and Herba Lycopi 8~ 10 parts.
Further, the detoxifying health-care product are mainly made up of the raw material of following parts by weight:
55~65 parts of radix glycyrrhizae, 55~65 parts of ginkgo leaf, 8.5~9.5 parts of rhizoma alismatis, 7.5~8.5 parts of oriental wormwood, turmeric 10.5~ 11.5 parts, 55~65 parts of lotus leaf, 18.5~19.5 parts of the fruit of Chinese wolfberry, 13.5~14.5 parts of peach kernel, 21~23 parts of dark plum, spina date seed 21 ~23 parts, 16~18 parts of ginseng, 8.5~9.5 parts of pilose antler, 8.5~9.5 parts of hippocampus, 13~14 parts of ganoderma lucidum, Ligusticum wallichii 8.5~9.5 Part, 8.5~9.5 parts of the bighead atractylodes rhizome, 6~7 parts of sealwort, 6~7 parts of radix bupleuri, 6~7 parts of the root of herbaceous peony, 6~7 parts of rascal, 6~7 parts of Radix Angelicae Sinensis, corn 8.5~9.5 parts of 8.5~9.5 parts of palpus, 8.5~9.5 parts of root tuber of aromatic turmeric and Herba Lycopi.
By the proportioning between Reasonable adjustment each component, the coordinated effect between each component is given full play to, is improved The health care curative effect of detoxifying health-care product, nutritious, mouthfeel is excellent, recovers total balance of the body, exclusion vivotoxin for regulation, reaches Stable health status has significant effect.
In a kind of optional embodiment, the formulation of the detoxifying health-care product is oral formulations.
In a kind of optional embodiment, the formulations of the detoxifying health-care product is tablet, capsule, granule, pill, Pulvis or oral liquid.
Preferably, the formulation of the detoxifying health-care product is oral liquid;Conveniently take, be easy to carry.
The detoxifying health-care product that present embodiment provides can be existing traditional oral pharmacy type, and preferably above-mentioned is several Kind formulation, but this is not limited to, can also be medicinal tea or other formulations, use is easy to carry, and effect of ejecting poison is good, in daily middle company The effect of continuous use can give full play to the cleaning of its toxin expelling, stimulate circulation.
Second aspect, present embodiment provide the preparation method of the detoxifying health-care product described in more than one, methods described bag Include following steps:
Each raw material is crushed respectively, alcohol extracting and drying, obtain each extract;
Each extract is mixed according to formula rate, the detoxifying health-care product are made.
It is that all raw materials are uniformly put into boiling in extractor to obtain stoste mostly in existing preparation method, This extraction mode of operation easily to contain chemical residual in a small number of raw materials, is also easy to so that patient vomiting occurs instead after taking Stomach, skin is itched or the adverse reaction such as eruption, dizzy phenomenon.
And the preparation method for the detoxifying health-care product that present embodiment provides, all raw materials in formula are special using its physics Property, by the way of single extraction, traditional extracting mode is changed, the chemical substance remained in medicine is reduced and human body is caused Injury, the effect of more efficiently improving product.
It should be noted that after each extract is mixed according to formula rate, enter according to method commonly used in the prior art Row preparation, so that granule, tablet or oral liquid etc. is made, you can obtain detoxifying health-care product.
Further speaking, the preparation method for the detoxifying health-care product that present embodiment provides, by the way that each raw material is carried out respectively Crushing, alcohol extracting and drying, the mode for then again mixing obtained each extract so that effective nutritional ingredient of each raw material obtains More preferable enrichment, reduces the invalid components in medicine, the effect of having given full play to each raw material, reduces residuals to human body Caused by infringement, be not in adverse reaction.The detoxifying health-care product being prepared by the above method, stability is good, safe nothing Toxic side effect, for excluding vivotoxin, regulation recovers total balance of the body, and resistance building has positive role, is easy to industrialize Production.
In a kind of optional embodiment, in described pulverising step, raw material is dried at 90 DEG C~115 DEG C first To constant weight, then crushed to obtain powdered raw material with mortar;
Preferably, the temperature of drying is 100 DEG C~105 DEG C;
Preferably, the granularity of crushing is the mesh of 60 mesh~80.
Alternatively, by before raw material stoving to constant weight, first raw material is cleaned, it is standby.
In a kind of specific embodiment, alternatively, the temperature of drying is 90 DEG C, 91 DEG C, 92 DEG C, 93 DEG C, 94 DEG C, 95 ℃、96℃、97℃、98℃、98℃、99℃、100℃、101℃、102℃、103℃、104℃、105℃、106℃、107℃、 108 DEG C, 109 DEG C, 110 DEG C, 111 DEG C, 112 DEG C, 113 DEG C, 114 DEG C or 115 DEG C.The drying temperature of each raw material is slightly poor in formula Not, such as the drying temperature of radix glycyrrhizae and ginkgo leaf is preferably 101 DEG C, and the drying temperature of rhizoma alismatis, oriental wormwood and turmeric is preferably 103 DEG C, the drying temperature of the fruit of Chinese wolfberry and peach kernel is preferably 99 DEG C, and the drying temperature of ginseng and pilose antler is preferably 97 DEG C etc..
In a kind of specific embodiment, alternatively, the granularity of powdered raw material is 60 mesh, 61 mesh, 62 mesh, 63 Mesh, 64 mesh, 65 mesh, 66 mesh, 67 mesh, 68 mesh, 69 mesh, 70 mesh, 71 mesh, 72 mesh, 73 mesh, 74 mesh, 75 mesh, 76 mesh, 77 mesh, 78 Mesh, 79 mesh or 80 mesh.The granularity that each raw material crushes in formula can also slightly have difference, but as long as within the above range.
In a kind of optional embodiment, in described alcohol extracting step, the raw material after crushing is weighed first, is placed on In extraction element, then add volumetric concentration and be 75%~90% ethanol solution heating and refluxing extraction 1~3 time, backflow every time carries The time taken is 1~3 hour, and reflux temperature is 85 DEG C~98 DEG C, and the quality of raw material and the volume ratio of ethanol solution are 1:10~ 30;
Preferably, the extraction element is apparatus,Soxhlet's;
Preferably, the volumetric concentration of the ethanol solution is 80%~85%;
Preferably, the time of each refluxing extraction is 2~2.5 hours, and reflux temperature is 88 DEG C~90 DEG C, the quality of raw material Volume ratio with ethanol solution is 1:20~22.
In a kind of specific embodiment, alternatively, the volumetric concentration of ethanol solution is 75%, 76%, 77%, 78%th, 79%, 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89% or 90%;Preferably 85%.
In a kind of specific embodiment, alternatively, the number of heating and refluxing extraction is 1 time, 2 times or 3 times.Using more It during secondary heating and refluxing extraction, parallel can carry out, i.e., the operating parameter all same extracted every time, each secondary extract solution merged after extraction.
In a kind of specific embodiment, alternatively, time of each refluxing extraction is 1 hour, 1.5 hours, it is 2 small When, 2.5 hours or 3 hours.
In a kind of specific embodiment, alternatively, reflux temperature be 85 DEG C, 86 DEG C, 87 DEG C, 88 DEG C, 89 DEG C, 90 DEG C, 91 DEG C, 92 DEG C, 93 DEG C, 94 DEG C, 95 DEG C, 96 DEG C, 97 DEG C or 98 DEG C.The reflux temperature of each raw material slightly has difference, example in formula Reflux temperature such as radix glycyrrhizae and ginkgo leaf is preferably 90 DEG C, and the reflux temperature of rhizoma alismatis, oriental wormwood and turmeric is preferably 93 DEG C, the fruit of Chinese wolfberry Reflux temperature with peach kernel is preferably 88 DEG C etc..
In a kind of specific embodiment, alternatively, the quality of raw material and volume ratio (the i.e. solid-liquid ratio g/ of ethanol solution ML it is) 1:10、1:12、1:15、1:18、1:20、1:22、1:25、1:28 or 1:30.
In a kind of optional embodiment, in described drying steps, ethanol is reclaimed using vacuum distillation mode first, Mucus is obtained, then mucus is dried, obtains extract;
Preferably, dry temperature is 85 DEG C~105 DEG C.
It should be noted that the mode of operation of recovery ethanol is evaporated under reduced pressure, can be according to the operation of existing recovery ethanol Condition is carried out, and is just not described in detail herein.
In a kind of specific embodiment, alternatively, the temperature that mucus is dried be 85 DEG C, 86 DEG C, 87 DEG C, 88 ℃、89℃、90℃、91℃、92℃、93℃、94℃、95℃、96℃、97℃、98℃、99℃、100℃、101℃、102℃、 103 DEG C, 104 DEG C or 105 DEG C.
So, by the mode of operation of above-mentioned crushing, alcohol extracting and drying, the active ingredient of raw material is enabled to obtain more Good enrichment, while there is the characteristics of water-soluble strong, purity is high and has stablized again.
The third aspect, the detoxifying health-care product that present embodiment provides described in more than one are being prepared with stool of dispelling, row's intestines Application in the medicine of poison, strengthening the spleen and stomach and/or clearing lung-heat expectoration effect.
The detoxifying health-care product that present embodiment provides, which are applied preparing, has stool of dispelling, expelling intestinal toxin, strengthening the spleen and stomach and/or clear In the medicine of lung expectoration effect, unnecessary side effect will not be brought to body, product purity is high, and stability is good, instant It is again quick, for excluding the toxin in vivo in the dirty insidious and blood of each internal organs, nourishing yin and nourishing blood, cleaning intestines product, stool of dispelling clearly, gut purge Toxin expelling, balance internal organs etc. plays the role of positive.
With reference to specific embodiment and comparative example, the invention will be further described.
Embodiment 1-4
A kind of detoxifying health-care product, are prepared according to the ratio of the parts by weight of the raw material shown in table 1.
The embodiment 1-4 detoxifying health-care product formulas of table 1
Raw material Embodiment 1 Embodiment 2 Embodiment 3 Embodiment 4
Radix glycyrrhizae 40 parts 50 parts 70 parts 80 parts
Ginkgo leaf 40 parts 50 parts 65 parts 80 parts
Rhizoma alismatis 5 parts 8 parts 9 parts 15 parts
Oriental wormwood 5 parts 7 parts 8 parts 12 parts
Turmeric 6 parts 10 parts 11 parts 16 parts
Lotus leaf 40 parts 50 parts 65 parts 80 parts
The fruit of Chinese wolfberry 12 parts 18 parts 19 parts 24 parts
Peach kernel 10 parts 13 parts 14 parts 18 parts
Dark plum 15 parts 20 parts 22 parts 30 parts
Spina date seed 15 parts 20 parts 22 parts 30 parts
Ginseng 10 parts 15 parts 17 parts 25 parts
Pilose antler 5 parts 8 parts 9 parts 15 parts
Hippocampus 5 parts 8 parts 9 parts 15 parts
Ganoderma lucidum 10 parts 12 parts 14 parts 18 parts
Ligusticum wallichii 5 parts 8 parts 9 parts 15 parts
The bighead atractylodes rhizome 5 parts 8 parts 9 parts 15 parts
Sealwort 2 parts 5 parts 7 parts 12 parts
Radix bupleuri 2 parts 5 parts 7 parts 12 parts
The root of herbaceous peony 2 parts 5 parts 6 parts 12 parts
Rascal 2 parts 5 parts 6 parts 12 parts
Radix Angelicae Sinensis 2 parts 2 parts 2 parts 12 parts
Corn stigma 5 parts 8 parts 9 parts 15 parts
Root tuber of aromatic turmeric 5 parts 8 parts 9 parts 15 parts
Herba Lycopi 15 parts 8 parts 9 parts 15 parts
Embodiment 5-8
The preparation method of detoxifying health-care product described in embodiment 1-4, comprises the following steps:
(a) first each raw material is cleaned, then is then crushed to obtain powder with mortar by each raw material stoving to constant weight respectively The raw material of last shape;
Wherein, the drying temperature of radix glycyrrhizae and ginkgo leaf is 101 DEG C, and the drying temperature of rhizoma alismatis, oriental wormwood and turmeric is 103 DEG C, The drying temperature of the fruit of Chinese wolfberry and peach kernel is 99 DEG C, and the drying temperature of ginseng and pilose antler is 97 DEG C, the baking of lotus leaf, dark plum and spina date seed Dry temperature is 98 DEG C, and hippocampus, ganoderma lucidum, Ligusticum wallichii, the bighead atractylodes rhizome, corn stigma, the drying temperature of root tuber of aromatic turmeric and Herba Lycopi are 104 DEG C, sealwort, bavin Recklessly, the drying temperature of the root of herbaceous peony, rascal and Radix Angelicae Sinensis is 105 DEG C;The granularity that each raw material crushes is 80 mesh.
(b) each raw material after a certain amount of crushing is weighed respectively, is placed in Soxhlet extraction device, is then added volume Concentration is 85% each raw material of ethanol solution heating and refluxing extraction, obtains each extract solution;
Wherein, the number of the heating and refluxing extraction of radix glycyrrhizae and ginkgo leaf is 2 times, and the time of each refluxing extraction is 2 hours, Reflux temperature is 90 DEG C, and the quality of raw material and the volume ratio of ethanol solution are 1:20;
The number of the heating and refluxing extraction of rhizoma alismatis, oriental wormwood and turmeric is 3 times, and the time of each refluxing extraction is 1 hour, is returned It is 93 DEG C to flow temperature, and the quality of raw material and the volume ratio of ethanol solution are 1:25;
The number of the heating and refluxing extraction of the fruit of Chinese wolfberry and peach kernel is 2 times, and the time of each refluxing extraction is 3 hours, backflow Temperature is 85 DEG C, and the quality of raw material and the volume ratio of ethanol solution are 1:30;
Ginseng, pilose antler, lotus leaf, the number of heating and refluxing extraction of dark plum and spina date seed are 1 time, and the time of refluxing extraction is 3 hours, reflux temperature was 96 DEG C, and the quality of raw material and the volume ratio of ethanol solution are 1:10;
The number of the heating and refluxing extraction of remaining raw material is 2 times, and the time of each refluxing extraction is 2 hours, reflux temperature For 92 DEG C, the quality of raw material and the volume ratio of ethanol solution are 1:20.
(c) each extract solution is used to the recovery ethanol of vacuum distillation mode, mucus is obtained, then mucus is dried, Dry temperature is 90 DEG C, obtains each extract;
(d) each extract is mixed according to formula rate, after being well mixed, detoxifying health-care product, the detoxifying health-care product is made Formulation be oral liquid.
Embodiment 9
The preparation method of detoxifying health-care product described in embodiment 3, comprises the following steps:
(a) first each raw material is cleaned, then is then crushed to obtain powder with mortar by each raw material stoving to constant weight respectively The raw material of last shape;
Wherein, the drying temperature of radix glycyrrhizae, ginkgo leaf, rhizoma alismatis, oriental wormwood and turmeric is 102 DEG C, the fruit of Chinese wolfberry, peach kernel, ginseng, deer Young pilose antler, lotus leaf, the drying temperature of dark plum and spina date seed are 98 DEG C, hippocampus, ganoderma lucidum, Ligusticum wallichii, the bighead atractylodes rhizome, corn stigma, root tuber of aromatic turmeric, Herba Lycopi, Huang Essence, radix bupleuri, the root of herbaceous peony, the drying temperature of rascal and Radix Angelicae Sinensis are 107 DEG C;The granularity that each raw material crushes is 60 mesh.
(b) each raw material after a certain amount of crushing is weighed respectively, is placed in Soxhlet extraction device, is then added volume Concentration is 80% each raw material of ethanol solution heating and refluxing extraction, obtains each extract solution;
Wherein, the number of the heating and refluxing extraction of rhizoma alismatis, oriental wormwood and turmeric is 3 times, and the time of each refluxing extraction is 1.5 Hour, reflux temperature is 95 DEG C, and the quality of raw material and the volume ratio of ethanol solution are 1:30;
The number of the heating and refluxing extraction of the fruit of Chinese wolfberry and peach kernel is 1 time, and the time of each refluxing extraction is 2.5 hours, is returned It is 92 DEG C to flow temperature, and the quality of raw material and the volume ratio of ethanol solution are 1:15;
Ginseng, pilose antler, lotus leaf, the number of heating and refluxing extraction of dark plum and spina date seed are 3 times, and the time of refluxing extraction is 1 hour, reflux temperature was 98 DEG C, and the quality of raw material and the volume ratio of ethanol solution are 1:22;
The number of the heating and refluxing extraction of remaining raw material is 2 times, and the time of each refluxing extraction is 2 hours, reflux temperature For 90 DEG C, the quality of raw material and the volume ratio of ethanol solution are 1:20.
Step (c) and (d) are same as Example 7.
Embodiment 10
The preparation method of detoxifying health-care product described in embodiment 3, as different from Example 9 step (c) and (d).
(c) each extract solution is used to the recovery ethanol of vacuum distillation mode, mucus is obtained, then mucus is dried, Dry temperature is 100 DEG C, obtains each extract;
(d) each extract is mixed according to formula rate, after being well mixed, detoxifying health-care product, the detoxifying health-care product is made Formulation be granule.
Embodiment 11
The preparation method of detoxifying health-care product described in embodiment 2, as different from Example 6, the agent of the detoxifying health-care product Type is pulvis.
Embodiment 12
The preparation method of detoxifying health-care product described in embodiment 2, as different from Example 6, the agent of the detoxifying health-care product Type is tablet.
Comparative example 1
A kind of detoxifying health-care product, in parts by weight, not including ginkgo leaf, other raw materials are the same as embodiment 3.
The preparation method of the detoxifying health-care product is the same as embodiment 7.
Comparative example 2
A kind of detoxifying health-care product, in parts by weight, not including lotus leaf, other raw materials are the same as embodiment 3.
The preparation method of the detoxifying health-care product is the same as embodiment 7.
Comparative example 3
A kind of detoxifying health-care product, in parts by weight, not including corn stigma, root tuber of aromatic turmeric and Herba Lycopi, other raw materials are the same as implementation Example 3.
The preparation method of the detoxifying health-care product is the same as embodiment 7.
Comparative example 4
A kind of detoxifying health-care product, are made up of the raw material of following parts by weight:
100 parts of radix glycyrrhizae, 90 parts of ginkgo leaf, 16 parts of rhizoma alismatis, 13 parts of oriental wormwood, 20 parts of turmeric, 85 parts of lotus leaf, 30 parts of the fruit of Chinese wolfberry, It is 25 parts of peach kernel, 50 parts of dark plum, 50 parts of spina date seed, 28 parts of ginseng, 16 parts of pilose antler, 20 parts of hippocampus, 20 parts of ganoderma lucidum, 30 parts of Ligusticum wallichii, white 20 parts of art, 13 parts of sealwort, 13 parts of radix bupleuri, 14 parts of the root of herbaceous peony, 15 parts of rascal, 14 parts of Radix Angelicae Sinensis, 18 parts of corn stigma, 18 parts of root tuber of aromatic turmeric and Herba Lycopi 18 parts.
Comparative example 5
A kind of detoxifying health-care product of the prior art, are made up of the raw material of following parts by weight:20 parts of semen astragali complanati, stinkweed 15 Part, 10 parts of the bark of eucommia, 16 parts of the fleece-flower root, 6 parts of Fruit of Catalpa Ovata G. Don and 12 parts of mung bean.
Comparative example 6
The preparation method of detoxifying health-care product described in embodiment 3, it is as different from Example 9, unified to dry all raw materials, Drying temperature is 100 DEG C;
All raw materials of unified alcohol extracting, the number of its heating and refluxing extraction is 2 times, and the time of each refluxing extraction is 2 hours, Reflux temperature is 92 DEG C, and the gross mass of raw material and the volume ratio of ethanol solution are 1:20.
Comparative example 7
Detoxifying health-care product described in embodiment 3 are prepared using the preparation method of prior art, comprised the following steps:
Add in distilling kettle after all starting material with water are soaked, after being boiled by fire, be boiled with soft fire 30 minutes;Boiling twice, so After filter, merge filtrate twice, be well mixed, obtain the detoxifying health-care product.
In order to verify the detoxifying health-care product of embodiment 5-10 and comparative example 1-7 offers in stool of dispelling, expelling intestinal toxin etc. Effect, has carried out following clinical test.Poor appetite, indigestion, abdominal distention, the stagnant intestines of stool, intestines poison delay etc. is sub- strong The people of health Disease 1300 (M-F 1:1, average age 38 years old), stochastic averagina is divided into 13 groups, corresponds to and uses embodiment 5- The detoxifying health-care product of 10 and comparative example 1-7 offer.Once a day, each dosage is 20mL, after one week, two weeks, is seen Log is examined, as shown in table 2.
The result of the test of table 2
Standard declaration is as follows:Healing refers to that the clinical symptoms such as the stagnant intestines of abdominal distention, stool are wholly absent;Effectively refer to gastral cavity abdomen The clinical symptoms such as the stagnant intestines of distending pain, stool have been alleviated, but effect is not wholly absent.
As shown in Table 2, embodiment 5-10 effect of ejecting poison is substantially better than comparative example 1-7, and especially embodiment 7 is provided Detoxifying health-care product, therapeutic effect more preferably, using cure rate after one week can reach 85%, and effective percentage can reach 90%, use two weeks Cure rate and effective percentage reach 100% afterwards.Thus explanation is using the detoxifying health-care product of the present invention, and for exclusion, each internal organs is dirty in vivo Insidious and blood in toxin, nourishing yin and nourishing blood, cleaning intestines product, stool of dispelling clearly, detoxicating intestine, balance internal organs etc. have significant Effect.
From the comparative analysis of comparative example 1-4 and embodiment 7, change the proportioning of each raw material in detoxifying health-care product so that The proportioning of raw material is not in the scope of protection of the invention, or deletes any one component or various ingredients therein, can not Realize the effect above, effect of ejecting poison is poor.Comparative example 1-3 is also further illustrated, ginkgo leaf, lotus selected by the present invention Mutual cooperation effect between the raw materials such as leaf, corn stigma, root tuber of aromatic turmeric, Herba Lycopi, wherein, ginkgo leaf or lotus leaf can be with other raw material groups Divide collaboration promotion, efficiently play the effect that toxin expelling is cleaned, stimulated circulation, can more meet the needs of patient, realize accurate, high Effect, safety and quickly effect of ejecting poison.
From the comparative analysis of comparative example 5 and embodiment 7, using detoxifying health-care product provided by the invention, for gastral cavity abdomen The therapeutic effect of the patients such as the stagnant intestines of distending pain, stool is better than existing common expellant medicament therapeutic effect.By comparative example 6,7 and in fact The comparative analysis for applying example 7 is understood, the preparation method of detoxifying health-care product provided by the invention, can more give full play to the work(of each raw material Effect so that effective nutritional ingredient of each raw material has obtained more preferable enrichment, reduces the invalid components in medicine, reduces residue Infringement caused by confrontation human body, safe to use, therapeutic effect is good.
Typical case:
1st, Mrs Huang, 40 years old, Guangzhou bank lobby manager, shortness of breath uncomfortable in chest often, sleep often suppressed awake, no gas of speaking Power, double knees suffer from synovitis, the long waist and leg ache of stand up time again, and head swoons failure of memory all day long.Take the present invention After the detoxifying health-care product of offer, from night 9 points 30 minutes or so to 10 points or so of the next morning common defecation more than 10 times, in watery stool There is the particle that green, yellow differ in size, each time with red small patch, body is a bit apprehensive when just drained, and stomach is slightly uncomfortable, Second day these symptom disappear, and breathing is smooth, and not only spirit has from head to foot also energetically people, on foot especially easily, oneself description As having changed individual, life from now on is full of confidence.
2nd, Mrs Qin, 45 years old, Chongqing City's hospital doctor, brain blood supply in recent years and myocardial blood supply are bad always, frequent chest Sulks are short, also suffer from duodenal ulcer, cholecystitis, kidney stone, pelvic infecton, fibroid, rheumatism etc., take the present invention and carry After the detoxifying health-care product of confession, that night 9: 10 separately begins to 30 minutes the next mornings 10 point common defecation 15 times, and black fungus shape thing is most It is more, also blackish green spherical particle, yellow corn scoriform etc..Of pink and healthy-looking, stomach, intestines, gall-bladder are uncomfortable after drained disappears, in the past from Do not perspire, perspire now normal, the blood vessel extravasated blood caused by injury is moved back on increased weight 3 kilograms (partially thin in the past), a left side after one month Distending pain disappears.
3rd, Mr. Chen, 35 years old, Zhejiang schoolman, prolonged constipation, face acnes, enterotoxin accumulation is excessive, enteron aisle And skin toxin expelling is not smooth, after taking detoxifying health-care product provided by the invention, same day defecation 6 times, after taking one week, constipation symptom obtains To the preferable effect alleviated, daily normal defecation is reached after taking two weeks, constipation symptom disappears, and acne substantially mitigates.
Finally it should be noted that:Various embodiments above is merely illustrative of the technical solution of the present invention, rather than its limitations;To the greatest extent The present invention is described in detail with reference to foregoing embodiments for pipe, it will be understood by those within the art that:Its according to The technical scheme described in foregoing embodiments can so be modified, either which part or all technical characteristic are entered Row equivalent substitution;And these modifications or replacement, the essence of appropriate technical solution is departed from various embodiments of the present invention technology The scope of scheme.

Claims (10)

1. a kind of detoxifying health-care product, it is characterised in that be mainly made up of the raw material of following parts by weight:
40~80 parts of radix glycyrrhizae, 40~80 parts of ginkgo leaf, 5~15 parts of rhizoma alismatis, 5~12 parts of oriental wormwood, 6~16 parts of turmeric, lotus leaf 40~ 80 parts, 12~24 parts of the fruit of Chinese wolfberry, 10~18 parts of peach kernel, 15~30 parts of dark plum, 15~30 parts of spina date seed, 10~25 parts of ginseng, deer Fine and soft 5~15 parts, 5~15 parts of hippocampus, 10~18 parts of ganoderma lucidum, 5~15 parts of Ligusticum wallichii, 5~15 parts of the bighead atractylodes rhizome, 2~12 parts of sealwort, radix bupleuri 2 ~12 parts, 2~12 parts of the root of herbaceous peony, 2~12 parts of rascal, 2~12 parts of Radix Angelicae Sinensis, 5~15 parts of corn stigma, 5~15 parts of root tuber of aromatic turmeric and Herba Lycopi 5~ 15 parts.
2. detoxifying health-care product according to claim 1, it is characterised in that be mainly made up of the raw material of following parts by weight:
50~70 parts of radix glycyrrhizae, 50~70 parts of ginkgo leaf, 8~10 parts of rhizoma alismatis, 7~9 parts of oriental wormwood, 10~12 parts of turmeric, lotus leaf 50~ 70 parts, 18~20 parts of the fruit of Chinese wolfberry, 13~15 parts of peach kernel, 20~25 parts of dark plum, 20~25 parts of spina date seed, 15~20 parts of ginseng, deer Fine and soft 8~10 parts, 8~10 parts of hippocampus, 12~15 parts of ganoderma lucidum, 8~10 parts of Ligusticum wallichii, 8~10 parts of the bighead atractylodes rhizome, 5~8 parts of sealwort, radix bupleuri 5~ 8~10 parts of 8 parts, 5~8 parts of the root of herbaceous peony, 5~8 parts of rascal, 5~8 parts of Radix Angelicae Sinensis, 8~10 parts of corn stigma, 8~10 parts of root tuber of aromatic turmeric and Herba Lycopi.
3. detoxifying health-care product according to claim 1, it is characterised in that be mainly made up of the raw material of following parts by weight:
55~65 parts of radix glycyrrhizae, 55~65 parts of ginkgo leaf, 8.5~9.5 parts of rhizoma alismatis, 7.5~8.5 parts of oriental wormwood, turmeric 10.5~11.5 Part, 55~65 parts of lotus leaf, 18.5~19.5 parts of the fruit of Chinese wolfberry, 13.5~14.5 parts of peach kernel, 21~23 parts of dark plum, spina date seed 21~23 It is part, 16~18 parts of ginseng, 8.5~9.5 parts of pilose antler, 8.5~9.5 parts of hippocampus, 13~14 parts of ganoderma lucidum, 8.5~9.5 parts of Ligusticum wallichii, white 8.5~9.5 parts of art, 6~7 parts of sealwort, 6~7 parts of radix bupleuri, 6~7 parts of the root of herbaceous peony, 6~7 parts of rascal, 6~7 parts of Radix Angelicae Sinensis, corn stigma 8.5 8.5~9.5 parts of~9.5 parts, 8.5~9.5 parts of root tuber of aromatic turmeric and Herba Lycopi.
4. the detoxifying health-care product according to any one of claims 1 to 3, it is characterised in that the formulation of the detoxifying health-care product For oral formulations.
5. detoxifying health-care product according to claim 4, it is characterised in that the formulation of the detoxifying health-care product is tablet, glue Wafer, granule, pill, pulvis or oral liquid.
6. the preparation method of the detoxifying health-care product as described in any one of Claims 1 to 5, it is characterised in that methods described includes Following steps:
Each raw material is crushed respectively, alcohol extracting and drying, obtain each extract;
Each extract is mixed according to formula rate, the detoxifying health-care product are made.
7. the preparation method of detoxifying health-care product according to claim 6, it is characterised in that first in described pulverising step Raw material is first dried to constant weight at 90 DEG C~115 DEG C, is then crushed to obtain powdered raw material with mortar;
Preferably, the temperature of drying is 100 DEG C~105 DEG C;
Preferably, the granularity of crushing is the mesh of 60 mesh~80.
8. the preparation method of the detoxifying health-care product according to claim 6 or 7, it is characterised in that in described alcohol extracting step, The raw material after crushing is weighed first, is placed in extraction element, and it is 75%~90% ethanol solution then to add volumetric concentration Heating and refluxing extraction 1~3 time, the time of each refluxing extraction is 1~3 hour, and reflux temperature is 85 DEG C~98 DEG C, the matter of raw material Amount and the volume ratio of ethanol solution are 1:10~30;
Preferably, the extraction element is apparatus,Soxhlet's;
Preferably, the volumetric concentration of the ethanol solution is 80%~85%;
Preferably, the time of each refluxing extraction is 2~2.5 hours, and reflux temperature is 88 DEG C~90 DEG C, the quality and second of raw material The volume ratio of alcoholic solution is 1:20~22.
9. the preparation method of detoxifying health-care product according to claim 8, it is characterised in that first in described drying steps Ethanol is first reclaimed using vacuum distillation mode, mucus is obtained, then mucus is dried, obtain extract;
Preferably, dry temperature is 85 DEG C~105 DEG C.
10. detoxifying health-care product according to any one of claims 1 to 5 prepare have dispel stool, expelling intestinal toxin, strengthening the spleen and stomach and/ Or the application in the medicine of clearing lung-heat expectoration effect.
CN201710709534.5A 2017-08-17 2017-08-17 Detoxifying health-care product and its preparation method and application Pending CN107412679A (en)

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Application publication date: 20171201