CN105213738A - A kind of Chinese medicine being used for the treatment of infantile constipation and preparation method thereof - Google Patents
A kind of Chinese medicine being used for the treatment of infantile constipation and preparation method thereof Download PDFInfo
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Abstract
A kind of Chinese medicine being used for the treatment of infantile constipation and preparation method thereof, in prescription containing weight portion is: Flos Chrysanthemi 8-20 part, Radix Angelicae Sinensis 8-15 part, Aloe 20-50 part, Mel 10-25 part, Semen Cassiae 8-20 part, Colla Corii Asini 5-15 part, Rhizoma Atractylodis Macrocephalae 8-15 part, Radix Glycyrrhizae 5-13 part, Radix Aucklandiae (Radix Vladimiriae) 6-11 part, Pericarpium Citri Reticulatae 10-20 part, Folium camelliae assamicae 5-17 part, Radix Oenotherae erythrosepalae 7-17 part, Radix Astragali 5-10 part, Endothelium Corneum Gigeriae Galli 3-15 part, Fructus Aurantii Immaturus 5-15 part.We are particularly useful for infantile constipation, the present invention loosening bowel to relieve constipation, rush down turbid toxin expelling product in use Colla Corii Asini, product that Chinese angelica blood supplementing is moisturized, the product of the Rhizoma Atractylodis Macrocephalae, Radix Astragali air making-up and spleen enlivening, monarch is various, play loosening bowel to relieve constipation altogether, rush down turbid toxin expelling, the merit of Replenishing QI and nourishing YIN, the scope of application is wider, the embodiment of the present invention 7 can be seen, confirm through pharmacodynamics test, Chinese medicine composition object height, middle dosage group all clearly can treat the function of constipation, the preparation process technique of granule of the present invention is simple, easy to operate applicable industrialized great production.
Description
Technical field
The present invention relates to treatment by Chinese herbs field, be specifically related to a kind of Chinese medicine composition for the treatment of infantile constipation and preparation method thereof.
Background technology
In actual life, a people in ten people, is just had to there is constipation problem.Constipation is said and is not really serious disease, but have a strong impact on the quality of life of people, many worries are brought to people, constipation is clinical common complicated symptom, along with the change of people's dietary structure and the impact of psychiatric and social factor, constipation sickness rate has and increases trend, and infantile constipation is also increasing.
The irregular training had regular movements with shortage of living can make the trained reflex of children's's defecation abnormal.Children's is by unexpected direct stimulation, or the flip-flop of environment and living habit also can cause the constipation of short-term.Lack physical exertion, intestinal wall muscle weakness can be caused, wriggle and slow down and constipation.Because defecation not in time fond of play, residence or living environment change, causing original bowl evacuation habit to change, is also major reason.
Constipation infant often shows as: awareness of defecation is few, just secondary also few; Defecation is difficult, effort; Defecation is not smooth; Constipation with dry stool, hard just, defecation is not felt only; Also usually there is the gastrointestinal symptom such as stomachache, abdominal distention, inappetence, vomiting.Part infant is also with agitation, dreaminess, the Behavioral disturbances such as to cry and scream.It is 10%-70% that Leoning reports constipation infant stomachache incidence rate, and abdominal distention is 20%-40%, and inappetence is 26%, and vomiting is 10%.Stomachache is usually positioned at left lower quadrant and umbilicus week, for paroxysmal, without diffusing, can alleviate after hot compress or defecation, blocks cause caused by enterospasm mainly due to feces.
Prolonged constipation can cause anorectal disorder; Gastrointestinal nerve dysfunction; Form feces ulcer, severe patient can cause intestinal perforation; Suffer from colon cancer, show according to data, serious constipation person about 10% trouble colon cancer; Constipation in children not only can make noxious substance be detained for a long time in vivo, infringement liver, kidney, also can affect the growth promoter of child, cause fat, the illness such as fatty liver.
The medicine of the treatment constipation of applying clinically at present has: osmotic laxative, irritant laxative, emollient laxative, permeability caccagogue etc.Osmotic laxative main representative medicine is magnesium sulfate.But because it can not make colon tension force increase, so the slow patient of those intestinal movements should not be used for.Irritant laxative because stimulate intestinal mucosa and intestinal wall plexus nervorum, and may cause large intestine myasthenia, forms drug dependence, is thus mainly used in stool incarceration and needs rapid relieving constipation person, unsuitable prolonged application.The main shortcoming of emollient laxative is that mouthfeel is poor, and act on weak, prolonged application can cause fat soluble vitamin absorption bad.The major defect of permeability caccagogue produces gas at bacterial action bottom fermentation, causes the senses of discomfort such as abdominal distention.Treatment infantile constipation adopt Chinese medicine are all a little eliminating fire and detoxication, the medicine of relieving constipation by purgation, these medicines are for the inappetence of infant, the symptoms such as abdominal distention stomachache are difficult to alleviate, Chinese medicine have accumulated abundant clinical experience in long-term treatment practice, but has the little of significant curative effect for infantile constipation.
Summary of the invention:
For the defect of prior art, the invention provides a kind of Chinese medicine composition for the treatment of infantile constipation, it can treat constipation quickly and effectively, greatly reducing again the stimulation to intestinal and other physiological damage.
The present invention is solved the problems of the technologies described above by following technical proposals:
The invention provides a kind of Chinese medicine being used for the treatment of infantile constipation, it is prepared by the Chinese medicinal components of following weight portion: Flos Chrysanthemi 8-20 part, Radix Angelicae Sinensis 8-15 part, Aloe 20-50 part, Mel 10-25 part, Semen Cassiae 8-20 part, Colla Corii Asini 5-15 part, Rhizoma Atractylodis Macrocephalae 8-15 part, Radix Glycyrrhizae 5-13 part, Radix Aucklandiae (Radix Vladimiriae) 6-11 part, Pericarpium Citri Reticulatae 10-20 part, Folium camelliae assamicae 5-17 part, Radix Oenotherae erythrosepalae 7-17 part, Radix Astragali 5-10 part.
In Chinese medicine composition described above, the Chinese medicine used all uses its conventional medicinal part to be used as medicine, and the dosage of drug used is reasonable, and improve effect to strengthen it further, described Chinese medicine granules also comprises Endothelium Corneum Gigeriae Galli 3-15 part, Fructus Aurantii Immaturus 5-15 part.
As a kind of embodiment preferred for this invention, described Chinese medicine composition is prepared by the Chinese medicinal components of following weight portion: Flos Chrysanthemi 12.5 parts, Radix Angelicae Sinensis 9 parts, Aloe 25 parts, Mel 11 parts, Semen Cassiae 14 parts, 10 parts, Colla Corii Asini, the Rhizoma Atractylodis Macrocephalae 14 parts, 5 parts, Radix Glycyrrhizae, Radix Aucklandiae (Radix Vladimiriae) 7 parts, Pericarpium Citri Reticulatae 15 parts, Folium camelliae assamicae 13.5 parts, Radix Oenotherae erythrosepalae 12 parts, the Radix Astragali 5 parts.
As another kind of embodiment preferred for this invention, described Chinese medicine composition is prepared by the Chinese medicinal components of following weight portion: Flos Chrysanthemi 12.5 parts, Radix Angelicae Sinensis 9 parts, Aloe 25 parts, Mel 11 parts, Semen Cassiae 14 parts, 10 parts, Colla Corii Asini, the Rhizoma Atractylodis Macrocephalae 14 parts, 5 parts, Radix Glycyrrhizae, Radix Aucklandiae (Radix Vladimiriae) 7 parts, Pericarpium Citri Reticulatae 15 parts, Folium camelliae assamicae 13.5 parts, Radix Oenotherae erythrosepalae 12 parts, the Radix Astragali 5 parts, Endothelium Corneum Gigeriae Galli 8 parts, Fructus Aurantii Immaturus 6 parts.
According to theory of Chinese medical science, in the present invention, each raw-material effect is as follows:
Aloe: bitter in the mouth, cold in nature.
Gui Jing: return liver, stomach, large intestine channel.
Function cures mainly: the dizziness of Liver Channel excess-heat, headache, tinnitus, agitation, constipation, pediatric epilepsy scared, infantile malnutrition, catharsis and toxin expelling.
Mel: sweet in the mouth, property is put down.
Gui Jing: return lung, spleen, large intestine channel.
Function cures mainly: invigorating middle warmer is moisturized, analgesic antidotal, for the empty pain of gastral cavity abdomen, and dryness of the lung dry cough, dryness of the intestine constipation; External treatment skin infection is not held back, burn due to hot liquid or fire.
Semen Cassiae: sweet in the mouth, cold in nature.
Gui Jing: return liver, large intestine channel.
Function cures mainly: clearing away heat to improve acuity of vision, loosening bowel to relieve constipation.For the puckery pain of conjunctival congestion, the many tear of photophobia, has a headache dizzy, poor vision, constipation.
Flos Chrysanthemi: bitter in the mouth, cold in nature.
Gui Jing: enter liver, stomach two warp.
Function cures mainly: disappear meat, and by wind-phlegm, expel the heat-evil removing toxic substances, promoting the production of body fluid to quench thirst, controls eruptive disease stomachache, dry cholera, dysentery.
Colla Corii Asini: sweet in the mouth, property is put down.
Gui Jing: return lung, liver, kidney channel.
Function cures mainly: YIN nourishing of enriching blood, and moisturizes hemostasis, and for blood deficiency and yellow complexion, dizzy cardiopalmus, flesh flaccidity is unable, dysphoria and insomnia, stirring-up of pathogenic wind in the interior resulting from deficiency, xeropulmonary cough, and chronic cough is spat blood, haematemesis hematuria, metrorrhagia of having blood in stool, vaginal bleeding during pregnancy.
The Rhizoma Atractylodis Macrocephalae: bitter in the mouth, warm in nature.
Gui Jing: return spleen, stomach warp.
Function cures mainly: invigorating the spleen and benefiting QI, dampness diuretic, and hidroschesis is antiabortive.For insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement.
Radix Glycyrrhizae: sweet in the mouth, property is put down.
Gui Jing: enter spleen, stomach, the heart, lung meridian.
Function cures mainly: invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain.
Clinical practice: be used for deficiency of QI in middle-JIAO, the treatment of the various Advanced cancers of deficiency of both QI and blood, for alleviating or lower the high strong property of some drugs and toxicity thereof in tumor compound recipe.
Radix Aucklandiae (Radix Vladimiriae): sweet in the mouth, warm in nature.
Gui Jing: return spleen, stomach, large intestine, gallbladder meridian.
Function cures mainly: can lead to manner, easing stomach-QI, row irritability, loose stagnant gas, and broken stagnation of QI is only distressed, and by cold air, peace cholera is vomited and diarrhoea, and vomiting regurgitation of food from the stomach, except painful abdominal mass addiction disease block, umbilicus abdominal distention and pain, antiabortive loose poison, controls dysentery required, and wards off pestilential pathogen miasma.
Fructus Aurantii Immaturus: bitter in the mouth, warm in nature.
Gui Jing: return spleen, stomach warp.
Function cures mainly: dispelling the stagnated QI removing food stagnancy, loose painful abdominal mass of reducing phlegm, and stops, feeling of fullness distending pain in stagnant, heavy after dysentery, constipation, the stagnant vapour lock thoracic obstruction of expectorant, blocked-up chest.
Folium camelliae assamicae: bitter in the mouth, cold in nature.
Gui Jing: enter liver, stomach two warp.
Function cures mainly: disappear meat, by wind-phlegm, expels the heat-evil, and removing toxic substances, promotes the production of body fluid, quench the thirst.Control eruptive disease stomachache, dry cholera, dysentery.
Radix Oenotherae erythrosepalae: sweet in the mouth, warm in nature.
Function cures mainly: wind-damp dispelling; Bone and muscle strengthening.Main anemofrigid-damp arthralgia; Soreness of bones and muscles
The Radix Astragali: sweet in the mouth, warm in nature.
Gui Jing: return lung, spleen channel.
Function cures mainly: invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, expelling pus and promoting granulation.Weak for the deficiency of vital energy, anorexia and loose stool, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, deficiency of vital energy edema, carbuncle difficulty is burst, and burst for a long time and do not hold back, blood deficiency dull yellowish colored skin, interior-heat is quenched one's thirst; Chronic nephritis proteinuria, diabetes.
Endothelium Corneum Gigeriae Galli: sweet in the mouth, property is put down.
Gui Jing: return spleen, stomach, small intestinal, urinary bladder channel.
Function cures mainly: invigorating the stomach and promoting digestion, and arresting seminal emission does not disappear for food stagnation, vomiting dysentery, infantile malnutrition, the enuresis, seminal emission
Radix Angelicae Sinensis: sweet in the mouth, warm in nature.
Gui Jing: return liver, the heart, spleen channel.
Function cures mainly: enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.For blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores.Radix Angelicae Sinensis (processed with wine) promoting blood circulation to restore menstrual flow.For amenorrhea dysmenorrhea, rheumatic arthralgia, injury from falling down.
Present invention also offers a kind of preparation method for the treatment of infantile constipation Chinese medicine granules, its preparation process comprises as follows:
(1) corresponding raw material components is taken according to weight for subsequent use;
(2) fine powder worn into by Colla Corii Asini, crosses 80-100 order and shines, for subsequent use;
(3) Semen Cassiae, the Rhizoma Atractylodis Macrocephalae, Radix Angelicae Sinensis, Fructus Aurantii Immaturus, the Radix Astragali, Radix Aucklandiae (Radix Vladimiriae), Endothelium Corneum Gigeriae Galli adopt alcohol extracting method, 40%-80% ethanol backwash 1-3 time, each 1-3 hour, and medicinal liquid filters, reclaim ethanol;
(4) first wash Folium camelliae assamicae open 15min with boiled water, remove filtrate, for subsequent use;
(5) by the Folium camelliae assamicae of step (4), Flos Chrysanthemi, Aloe, Radix Glycyrrhizae, Pericarpium Citri Reticulatae, Radix Oenotherae erythrosepalae, be 1:6-10 according to the weight ratio with water, decoct secondary, first time 1.5-2.5 hour, second time 0.5-1 hour, collecting decoction, filters, and leaves standstill;
(6) get the supernatant in step (5) and step (3), adding Mel, to be concentrated into relative density be 1.2-12.5, puts to room temperature and cool, adding ethanol makes alcohol content reach 75%, stirs evenly, and leaves standstill, get supernatant, reclaim ethanol, be condensed into the clear paste that relative density is 1.25;
(7) get the clear paste in step (3), add Colla Corii Asini powder, measure its weight, add the sucrose of its weight 25% and the mixture of dextrin, in the mixture of wherein lactose and dextrin, the weight ratio of lactose and dextrin is 3:1; Stir and be heated to 80 ~ 90 DEG C, cross 80 mesh sieves, obtain extract powder with spray dryer, namely subpackage obtains granule.
The present invention also provides a kind of medical usage of above-mentioned Chinese medicine composition, the purposes of namely described Chinese medicine composition in preparation infantile constipation medicine.
According to above theory of Chinese medical science, use Aloe excess-heat dizzy in the present invention, headache tinnitus, irritated constipation, pediatric epilepsy scared, catharsis and toxin expelling, Mel is used for invigorating middle warmer and moisturizes, analgesic antidotal, relieving cough and moistening lung, loosening bowel to relieve constipation, this prescription with Aloe and Mel for monarch drug, Semen Cassiae, Flos Chrysanthemi, Folium camelliae assamicae, Colla Corii Asini, when being classified as ministerial drug, four associate with monarch drug, complement each other, play nourishing YIN and clearing away heat altogether, the merit of loosening bowel to relieve constipation, the Rhizoma Atractylodis Macrocephalae, Radix Aucklandiae (Radix Vladimiriae), the Radix Astragali, Radix Oenotherae erythrosepalae is adjuvant drug, adjuvant drug 5 is used, effect of air making-up and spleen enlivening is stronger, adjuvant drug is role in we, one is consolidate vigour, and assistant helps Colla Corii Asini, Radix Angelicae Sinensis nourishing essence-blood, improve immunity, two is the high property of rushing down of assistant monarch drug bitter cold processed, in case lose imapirment of the spleen and stomach, nourish health, Radix Glycyrrhizae mainly allocates each side for making medicine, full side is guided to act on taste, middle burnt taste are made to recover the normal function of ascending the clear and descending the turbid gradually.
Compared with prior art, the main advantage of the present invention when treating infantile constipation shows:
(1) we are particularly useful for infantile constipation, the present invention loosening bowel to relieve constipation, rush down turbid toxin expelling product in use Colla Corii Asini, product that Chinese angelica blood supplementing is moisturized, the product of the Rhizoma Atractylodis Macrocephalae, Radix Astragali air making-up and spleen enlivening, monarch is various, plays loosening bowel to relieve constipation altogether, rush down turbid toxin expelling, the merit of Replenishing QI and nourishing YIN, the scope of application is wider, and the embodiment of the present invention 7 can be seen, confirm through pharmacodynamics test, Chinese medicine composition object height, middle dosage group all clearly can treat the function of constipation.
(2) the present invention is made up of plurality of Chinese, and pharmacodynamics test confirms, therapeutic effect is obviously better than existing Western medicine, side effect is less, is better than traditional western medicine, is confirmed further by clinical trial, preparation prescription curative effect of the present invention is obvious, can apply at clinical further genralrlization.
(3) the preparation process technique of granule of the present invention is simple, easy to operate applicable industrialized great production.
Detailed description of the invention
Further describe the present invention below by way of specific embodiment, the present invention is not limited only to following examples.Within the scope of the invention or not departing from content of the present invention, spirit and scope, the change that the present invention is carried out, combination or replacement,
Be apparent for a person skilled in the art, and be included within the scope of the present invention.
Embodiment 1:
Flos Chrysanthemi 8g, Radix Angelicae Sinensis 8g, Aloe 20g, Mel 10g, Semen Cassiae 8g, Colla Corii Asini 5g, Rhizoma Atractylodis Macrocephalae 8g, Radix Glycyrrhizae 5g, Radix Aucklandiae (Radix Vladimiriae) 6g, Pericarpium Citri Reticulatae 10g, Folium camelliae assamicae 5g, Radix Oenotherae erythrosepalae 7g, Radix Astragali 5g.
Treat a Chinese medicine composition for infantile constipation, concrete preparation method is:
(1) corresponding raw material components is taken according to weight for subsequent use;
(2) fine powder worn into by Colla Corii Asini, crosses 80 orders and shines, for subsequent use;
(3) Semen Cassiae, the Rhizoma Atractylodis Macrocephalae, Radix Angelicae Sinensis, the Radix Astragali, Radix Aucklandiae (Radix Vladimiriae) adopt alcohol extracting method, 40% ethanol backwash 1 time, each 1 hour, and medicinal liquid filters, reclaim ethanol;
(4) first wash Folium camelliae assamicae open 15min with boiled water, remove filtrate, for subsequent use;
(5) by the Folium camelliae assamicae of step (4), Flos Chrysanthemi, Aloe, Radix Glycyrrhizae, Pericarpium Citri Reticulatae, Radix Oenotherae erythrosepalae, be 1:6 according to the weight ratio with water, decoct secondary, 1.5 hours first times, second time 0.5 hour, collecting decoction, filter, leave standstill;
(6) get the supernatant in step (5) and step (3), adding Mel, to be concentrated into relative density be 1.2, puts to room temperature and cool, adding ethanol makes alcohol content reach 75%, stirs evenly, and leaves standstill, get supernatant, reclaim ethanol, be condensed into the clear paste that relative density is 1.25;
(7) get the clear paste in step (3), add Colla Corii Asini powder, measure its weight, add the sucrose of its weight 25% and the mixture of dextrin, in the mixture of wherein lactose and dextrin, the weight ratio of lactose and dextrin is 3:1; Stir and be heated to 80 DEG C, cross 80 mesh sieves, obtain extract powder with spray dryer, namely subpackage obtains granule.
Embodiment 2:
Flos Chrysanthemi 20g, Radix Angelicae Sinensis 15g, Aloe 50g, Mel 25g, Semen Cassiae 20g, Colla Corii Asini 15g, Rhizoma Atractylodis Macrocephalae 15g, Radix Glycyrrhizae 13g, Radix Aucklandiae (Radix Vladimiriae) 11g, Pericarpium Citri Reticulatae 20g, Folium camelliae assamicae 17g, Radix Oenotherae erythrosepalae 17g, Radix Astragali 10g.
Treat a Chinese medicine composition for infantile constipation, concrete preparation method is:
(1) corresponding raw material components is taken according to weight for subsequent use;
(2) fine powder worn into by Colla Corii Asini, crosses 100 orders and shines, for subsequent use;
(3) Semen Cassiae, the Rhizoma Atractylodis Macrocephalae, Radix Angelicae Sinensis, the Radix Astragali, Radix Aucklandiae (Radix Vladimiriae) adopt alcohol extracting method, 80% ethanol backwash 3 times, each 3 hours, and medicinal liquid filters, reclaim ethanol;
(4) first wash Folium camelliae assamicae open 15min with boiled water, remove filtrate, for subsequent use;
(5) by the Folium camelliae assamicae of step (4), Flos Chrysanthemi, Aloe, Radix Glycyrrhizae, Pericarpium Citri Reticulatae, Radix Oenotherae erythrosepalae, be 1:10 according to the weight ratio with water, decoct secondary, 2.5 hours first times, second time 1 hour, collecting decoction, filter, leave standstill;
(6) get the supernatant in step (5) and step (3), adding Mel, to be concentrated into relative density be 1.2.5, puts to room temperature and cool, adding ethanol makes alcohol content reach 75%, stirs evenly, and leaves standstill, get supernatant, reclaim ethanol, be condensed into the clear paste that relative density is 1.25;
(7) get the clear paste in step (3), add Colla Corii Asini powder, measure its weight, add the sucrose of its weight 25% and the mixture of dextrin, in the mixture of wherein lactose and dextrin, the weight ratio of lactose and dextrin is 3:1; Stir and be heated to 90 DEG C, cross 80 mesh sieves, obtain extract powder with spray dryer, namely subpackage obtains granule.
Embodiment 3:
Flos Chrysanthemi 12.5g, Radix Angelicae Sinensis 8-15g, Aloe 25g, Mel 11g, Semen Cassiae 14g, Colla Corii Asini 10g, Rhizoma Atractylodis Macrocephalae 14g, Radix Glycyrrhizae 5g, Radix Aucklandiae (Radix Vladimiriae) 7g, Pericarpium Citri Reticulatae 15g, Folium camelliae assamicae 13.5g, Radix Oenotherae erythrosepalae 12g, Radix Astragali 5g.
Treat a Chinese medicine composition for infantile constipation, concrete preparation method is:
(1) corresponding raw material components is taken according to weight for subsequent use;
(2) fine powder worn into by Colla Corii Asini, crosses 80 orders and shines, for subsequent use;
(3) Semen Cassiae, the Rhizoma Atractylodis Macrocephalae, Radix Angelicae Sinensis, the Radix Astragali, Radix Aucklandiae (Radix Vladimiriae) adopt alcohol extracting method, 60% ethanol backwash 2 times, each 2 hours, and medicinal liquid filters, reclaim ethanol;
(4) first wash Folium camelliae assamicae open 15min with boiled water, remove filtrate, for subsequent use;
(5) by the Folium camelliae assamicae of step (4), Flos Chrysanthemi, Aloe, Radix Glycyrrhizae, Pericarpium Citri Reticulatae, Radix Oenotherae erythrosepalae, be 1:8 according to the weight ratio with water, decoct secondary, 2 hours first times, second time 1 hour, collecting decoction, filter, leave standstill;
(6) get the supernatant in step (5) and step (3), adding Mel, to be concentrated into relative density be 1.2, puts to room temperature and cool, adding ethanol makes alcohol content reach 75%, stirs evenly, and leaves standstill, get supernatant, reclaim ethanol, be condensed into the clear paste that relative density is 1.25;
(7) get the clear paste in step (3), add Colla Corii Asini powder, measure its weight, add the sucrose of its weight 25% and the mixture of dextrin, in the mixture of wherein lactose and dextrin, the weight ratio of lactose and dextrin is 3:1; Stir and be heated to 85 DEG C, cross 80 mesh sieves, obtain extract powder with spray dryer, namely subpackage obtains granule.
Embodiment 4:
Flos Chrysanthemi 8g, Radix Angelicae Sinensis 8g, Aloe 20g, Mel 10g, Semen Cassiae 8g, Colla Corii Asini 5g, Rhizoma Atractylodis Macrocephalae 8g, Radix Glycyrrhizae 5g, Radix Aucklandiae (Radix Vladimiriae) 6g, Pericarpium Citri Reticulatae 10g, Folium camelliae assamicae 5g, Radix Oenotherae erythrosepalae 7g, Radix Astragali 5g, Endothelium Corneum Gigeriae Galli 3g, Fructus Aurantii Immaturus 5g.
Treat a Chinese medicine composition for infantile constipation, concrete preparation method is:
(1) corresponding raw material components is taken according to weight for subsequent use;
(2) fine powder worn into by Colla Corii Asini, crosses 80 orders and shines, for subsequent use;
(3) Semen Cassiae, the Rhizoma Atractylodis Macrocephalae, Fructus Aurantii Immaturus, the Radix Astragali, Radix Aucklandiae (Radix Vladimiriae), Radix Angelicae Sinensis, Endothelium Corneum Gigeriae Galli adopt alcohol extracting method, 60% ethanol backwash 2 times, each 2 hours, and medicinal liquid filters, reclaim ethanol;
(4) first wash Folium camelliae assamicae open 15min with boiled water, remove filtrate, for subsequent use;
(5) by the Folium camelliae assamicae of step (4), Flos Chrysanthemi, Aloe, Radix Glycyrrhizae, Pericarpium Citri Reticulatae, Radix Oenotherae erythrosepalae, be 1:8 according to the weight ratio with water, decoct secondary, 2 hours first times, second time 1 hour, collecting decoction, filter, leave standstill;
(6) get the supernatant in step (5) and step (3), adding Mel, to be concentrated into relative density be 1.2, puts to room temperature and cool, adding ethanol makes alcohol content reach 75%, stirs evenly, and leaves standstill, get supernatant, reclaim ethanol, be condensed into the clear paste that relative density is 1.25;
(7) get the clear paste in step (3), add Colla Corii Asini powder, measure its weight, add the sucrose of its weight 25% and the mixture of dextrin, in the mixture of wherein lactose and dextrin, the weight ratio of lactose and dextrin is 3:1; Stir and be heated to 85 DEG C, cross 80 mesh sieves, obtain extract powder with spray dryer, namely subpackage obtains granule.
Embodiment 5:
Flos Chrysanthemi 20g, Radix Angelicae Sinensis 15g, Aloe 50g, Mel 25g, Semen Cassiae 20g, Colla Corii Asini 15g, Rhizoma Atractylodis Macrocephalae 15g, Radix Glycyrrhizae 13g, Radix Aucklandiae (Radix Vladimiriae) 11g, Pericarpium Citri Reticulatae 20g, Folium camelliae assamicae 17g, Radix Oenotherae erythrosepalae 17g, Radix Astragali 10g, Endothelium Corneum Gigeriae Galli 15g, Fructus Aurantii Immaturus 15g.
Treat a Chinese medicine composition for infantile constipation, concrete preparation method is:
(1) corresponding raw material components is taken according to weight for subsequent use;
(2) fine powder worn into by Colla Corii Asini, crosses 80 orders and shines, for subsequent use;
(3) Semen Cassiae, the Rhizoma Atractylodis Macrocephalae, Fructus Aurantii Immaturus, the Radix Astragali, Radix Aucklandiae (Radix Vladimiriae), Radix Angelicae Sinensis, Endothelium Corneum Gigeriae Galli adopt alcohol extracting method, 60% ethanol backwash 2 times, each 2 hours, and medicinal liquid filters, reclaim ethanol;
(4) first wash Folium camelliae assamicae open 15min with boiled water, remove filtrate, for subsequent use;
(5) by the Folium camelliae assamicae of step (4), Flos Chrysanthemi, Aloe, Radix Glycyrrhizae, Pericarpium Citri Reticulatae, Radix Oenotherae erythrosepalae, be 1:8 according to the weight ratio with water, decoct secondary, 2 hours first times, second time 1 hour, collecting decoction, filter, leave standstill;
(6) get the supernatant in step (5) and step (3), adding Mel, to be concentrated into relative density be 1.2, puts to room temperature and cool, adding ethanol makes alcohol content reach 75%, stirs evenly, and leaves standstill, get supernatant, reclaim ethanol, be condensed into the clear paste that relative density is 1.25;
(7) get the clear paste in step (3), add Colla Corii Asini powder, measure its weight, add the sucrose of its weight 25% and the mixture of dextrin, in the mixture of wherein lactose and dextrin, the weight ratio of lactose and dextrin is 3:1; Stir and be heated to 85 DEG C, cross 80 mesh sieves, obtain extract powder with spray dryer, namely subpackage obtains granule.
Embodiment 6:
Aloe 25g, Mel 11g, Semen Cassiae 14g, Colla Corii Asini 10g, Flos Chrysanthemi 12.5g, Rhizoma Atractylodis Macrocephalae 14g, Radix Glycyrrhizae 5g, Radix Aucklandiae (Radix Vladimiriae) 7g, Pericarpium Citri Reticulatae 15g, Folium camelliae assamicae 13.5g, Radix Oenotherae erythrosepalae 12g, Radix Astragali 5g, Radix Angelicae Sinensis 14.5g, Endothelium Corneum Gigeriae Galli 8g, Fructus Aurantii Immaturus 7g.
Treat a Chinese medicine composition for infantile constipation, concrete preparation method is:
(1) corresponding raw material components is taken according to weight for subsequent use;
(2) fine powder worn into by Colla Corii Asini, crosses 80 orders and shines, for subsequent use;
(3) Semen Cassiae, the Rhizoma Atractylodis Macrocephalae, Fructus Aurantii Immaturus, the Radix Astragali, Radix Aucklandiae (Radix Vladimiriae), Radix Angelicae Sinensis, Endothelium Corneum Gigeriae Galli adopt alcohol extracting method, 60% ethanol backwash 2 times, each 2 hours, and medicinal liquid filters, reclaim ethanol;
(4) first wash Folium camelliae assamicae open 15min with boiled water, remove filtrate, for subsequent use;
(5) by the Folium camelliae assamicae of step (4), Flos Chrysanthemi, Aloe, Radix Glycyrrhizae, Pericarpium Citri Reticulatae, Radix Oenotherae erythrosepalae, be 1:8 according to the weight ratio with water, decoct secondary, 2 hours first times, second time 1 hour, collecting decoction, filter, leave standstill;
(6) get the supernatant in step (5) and step (3), adding Mel, to be concentrated into relative density be 1.2, puts to room temperature and cool, adding ethanol makes alcohol content reach 75%, stirs evenly, and leaves standstill, get supernatant, reclaim ethanol, be condensed into the clear paste that relative density is 1.25;
(7) get the clear paste in step (3), add Colla Corii Asini powder, measure its weight, add the sucrose of its weight 25% and the mixture of dextrin, in the mixture of wherein lactose and dextrin, the weight ratio of lactose and dextrin is 3:1; Stir and be heated to 85 DEG C, cross 80 mesh sieves, obtain extract powder with spray dryer, namely subpackage obtains granule.
Embodiment 7: observe invention formulation to the impact of Constipation Model mouse small intestine fltting speed.
Its chemical name of compound diphenoxylate is 1-(3,3-diphenyl-3-cyanopropyl)-4-phenyl-4-piperidine ethyl formate hydrochlorate, in treatment merit rushing down property can in the acute and chronic enteritis with slow abdomen, effectively suppress gastrointestinal motility, excessive use causes bowel movement function to reduce, and phenolphthalein tablets is used for the treatment of habitual obstipation simultaneously, therapeutic effect is better, certain degree can be improved the symptom of constipation, therefore, in the present invention phenolphthalein tablets is tested as positive control.
7.1, animal model and administration
Animal model: Kunming mouse 50, male and female dual-purpose, body weight 18-22g, raise in advance and conform for 3rd, each treated animal fasting 24h (freely drinking water) on pretreatment, on-test, model group, positive group and invention formulation 3 dosage groups all give compound diphenoxylate by 25mg/kg, and blank group gives equal-volume distilled water.
Administration: mice is divided into 7 groups at random: dosage group (4.2g/kg), Chinese medicine composition low dose group (2.1g/kg) in Normal group, model group, phenolphthalein tablets group (mg/kg), Chinese medicine composition high dose group (8.3g/kg), Chinese medicine composition, often organizes 10; Wherein get the embodiment of the present invention 6 granule with 10% charcoal end aqueous solution medicinal liquid, as large, medium and small dosage group, the phenolphthalein tablets charcoal end aqueous solution of 10% is configured to 0.20mg/ml, by 10ml/kg gastric infusion, phenolphthalein tablets 1.95mg/kg as test positive drug control group, the blank group of charcoal end aqueous solution giving 10% of same volume.
7.2, experimentation and result
Each treated animal fasting 24h (freely drinking water) before experiment, on-test, model group, phenolphthalein group and invention formulation 3 dosage groups all give compound diphenoxylate by 25mg/kg, and blank group gives equal-volume distilled water.After 30min by 10ml/kg give respectively corresponding dosage containing 10% charcoal end drug suspension.After 30min, de-cervical vertebra puts to death animal, open abdominal cavity and be separated mesentery, clip upper end from pylorus, lower end to the intestinal tube of ileocecus, be placed on glass plate, gently small intestinal is pulled into straight line, measuring Length of intestine is " total small intestinal length ", is " prepared Chinese ink propelling length " from pylorus to prepared Chinese ink forward position, ink progradation between calculating group.Result of the test is through statistical procedures, and detailed results is in table 1.
The computational methods of propelling rate are:
Propelling rate=[(distance of charcoal end leading portion and the pylorus)/small intestinal whole audience] × 100%
Table 1. invention formulation is on the impact of mice with constipation intestinal propulsion
| Group | Dosage (g/kg) | Number of animals (n) | Propelling rate (%) |
| Blank group | 10 | 48.055±2.551 |
| Model group | 10 | 26.751±7.699 ## | |
| Phenolphthalein tablets group | 2 | 10 | 43.258±6.329 |
| Chinese medicine composition high dose group | 8.3 | 10 | 51.214±10.963 **& |
| Dosage group in Chinese medicine composition | 4.2 | 10 | 46.327±11.484 * |
| Chinese medicine composition low dose group | 2.1 | 10 | 40.129±12.325 * |
Compare with blank group and there is extremely significant difference
##p < 0.01;
Compare with model group and there is significant difference
*p < 0.05,
*p < 0.01;
With phenolphthalein tablets group ratio, there is significant difference
aMP.AMp.Ampp < 0.05.
From table 1, invention formulation 8.3g, 4.2g/kg dosage group has the effect obviously promoting Constipation Model mouse small intestine wriggling, and there is significant difference (* P < 0.05, * P < 0.01), Chinese medicine composition high dose group of the present invention have compared with phenolphthalein tablets group significant difference (
*p < 0.05).
Embodiment 8: clinical trial
In order to verify clinical effectiveness of the present invention further, within 2012, receive 213 routine constipation infants so far altogether, at 6 months-3 years old age, the mean age is 1.5 years old, and this Chinese medicine composition has significant curative effect to infantile constipation, carries out treatment follow the trail of statistics to above-mentioned infant.
8.1, grouping and administering mode
Treating 1. group: the granule of the embodiment of the present invention 3, one day twice, each 2.5g, 7 days is a course for the treatment of;
Treating 2. group: the granule of the embodiment of the present invention 6, one day twice, each 2.5g, 7 days is a course for the treatment of;
Observation group: Xiao ' erqixingcha granule, three times on the one, each half bag 7 days is a course for the treatment of 1.
8.2, diagnostic criteria
According to Fc RomeⅢdiagnostic criteria:
8.2.1, neonate/child (G7): neonate 0 ~ 4 years old child, at least occurs following 2 symptoms, reach month.
(1) defecation≤2 time/week;
(2) after oneself can control defecation, have 1 time/all incontinence outbreaks at least;
(3) stool retention medical history is had;
(4) defecation pain and effort history is had;
(5) there is a large amount of feces agglomerate in internal rectum;
(6) huge feces once blocked lavatory.
Above concomitant symptom comprises irritability, appetite declines and (or) early satisfy.Along with a large amount of feces is discharged, simultaneous phenomenon can disappear very soon.
8.2.2, the age is at least 4 years old child, must meet following 2 or more, and not meet the diagnostic criteria of irritable bowel syndrome (IBS):
(1) defecation≤2 time/week;
(2) 1 time/all fecal incontinence are had at least;
(3) there is a large amount of feces retention or have the posture relevant with feces retention; (
(4) defecation pain or difficult medical history is had;
(5) there is human excrement block in internal rectum;
(6) huge feces once blocked lavatory.Within before making a definite diagnosis at least 2 months, meet above-mentioned standard; And show effect at least 1 time/week.
8.3, curative effect diagnosis and clinical effectiveness
Recovery from illness: free movement of the bowels, matter is soft, and pain, abdominal distention, inappetence symptom are all eliminated;
Effective: defecate more unobstructed, matter is softer, painless, abdominal distention, inappetence symptom are eliminated substantially;
Invalid: not improve with original the same;
Effective percentage: (recovery from illness+effective)/this group infant sum.
Take through two courses for the treatment of continuously, 1. treatment group organizes recovery from illness infant is 54 examples, and effective is 16 examples, invalid 1 example, and treatment group is group 2., individual 62 examples of recovery from illness, effective individual 9 examples, and invalid individuality is 0 example; Observation group's recovery from illness 41 example, effective 18 examples, invalid 12 examples, concrete outcome is in table 2.
The treatment situation of table 2 treatment group and observation group
| Group | Recovery from illness | Effective | Invalid | Effective percentage (%) |
| Treat 1. group | 54 | 16 | 1 | 98.59 |
| Treat 2. group | 62 | 9 | 0 | 100 |
| Observation group | 41 | 18 | 12 | 83.10 |
Carry out follow-up investigation to above-mentioned 213 infants, treatment group only has 1 example to occur laxativeness phenomenon, and phenomenon of suffering from diarrhoea after drug withdrawal disappears, and there are 3 infant laxativeness in observation group, and pruritus, causalgia phenomenon appear in 3 infants, illustrates that prescription safety of the present invention is higher.
Claims (7)
1. be used for the treatment of a Chinese medicine for infantile constipation, it is prepared by the Chinese medicinal components of following weight portion: Flos Chrysanthemi 8-20 part, Radix Angelicae Sinensis 8-15 part, Aloe 20-50 part, Mel 10-25 part, Semen Cassiae 8-20 part, Colla Corii Asini 5-15 part, Rhizoma Atractylodis Macrocephalae 8-15 part, Radix Glycyrrhizae 5-13 part, Radix Aucklandiae (Radix Vladimiriae) 6-11 part, Pericarpium Citri Reticulatae 10-20 part, Folium camelliae assamicae 5-17 part, Radix Oenotherae erythrosepalae 7-17 part, Radix Astragali 5-10 part.
2. Chinese medicine as claimed in claim 1, it is characterized in that, described Chinese medicine also comprises Endothelium Corneum Gigeriae Galli 3-15 part, Fructus Aurantii Immaturus 5-15 part.
3. Chinese medicine as claimed in claim 1, it is characterized in that, described Chinese medicine is prepared by the Chinese medicinal components of following weight portion: Flos Chrysanthemi 12.5 parts, Radix Angelicae Sinensis 9 parts, Aloe 25 parts, Mel 11 parts, Semen Cassiae 14 parts, 10 parts, Colla Corii Asini, the Rhizoma Atractylodis Macrocephalae 14 parts, 5 parts, Radix Glycyrrhizae, Radix Aucklandiae (Radix Vladimiriae) 7 parts, Pericarpium Citri Reticulatae 15 parts, Folium camelliae assamicae 13.5 parts, Radix Oenotherae erythrosepalae 12 parts, the Radix Astragali 5 parts.
4. Chinese medicine as claimed in claim 2, it is characterized in that, described Chinese medicine is prepared by the Chinese medicinal components of following weight portion: Flos Chrysanthemi 12.5 parts, Radix Angelicae Sinensis 9 parts, Aloe 25 parts, Mel 11 parts, Semen Cassiae 14 parts, 10 parts, Colla Corii Asini, the Rhizoma Atractylodis Macrocephalae 14 parts, 5 parts, Radix Glycyrrhizae, Radix Aucklandiae (Radix Vladimiriae) 7 parts, Pericarpium Citri Reticulatae 15 parts, Folium camelliae assamicae 13.5 parts, Radix Oenotherae erythrosepalae 12 parts, the Radix Astragali 5 parts, Endothelium Corneum Gigeriae Galli 8 parts, Fructus Aurantii Immaturus 6 parts.
5. prepare a granule method for the Chinese medicine of the treatment infantile constipation described in claim 1 or 2, it comprises the steps:
(1) corresponding raw material components is taken according to weight for subsequent use;
(2) fine powder worn into by Colla Corii Asini, crosses 80-100 order and shines, for subsequent use;
(3) Semen Cassiae, the Rhizoma Atractylodis Macrocephalae, Radix Angelicae Sinensis, Fructus Aurantii Immaturus, the Radix Astragali, Radix Aucklandiae (Radix Vladimiriae), Endothelium Corneum Gigeriae Galli adopt alcohol extracting method, 40%-80% ethanol backwash 1-3 time, each 1-3 hour, and medicinal liquid filters, reclaim ethanol;
(4) first wash Folium camelliae assamicae open 15min with boiled water, remove filtrate, for subsequent use;
(5) by the Folium camelliae assamicae of step (4), Flos Chrysanthemi, Aloe, Radix Glycyrrhizae, Pericarpium Citri Reticulatae, Radix Oenotherae erythrosepalae, be 1:6-10 according to the weight ratio with water, decoct secondary, first time 1.5-2.5 hour, second time 0.5-1 hour, collecting decoction, filters, and leaves standstill;
(6) get the supernatant in step (5) and step (3), adding Mel, to be concentrated into relative density be 1.2-12.5, puts to room temperature and cool, adding ethanol makes alcohol content reach 75%, stirs evenly, and leaves standstill, get supernatant, reclaim ethanol, be condensed into the clear paste that relative density is 1.25;
(7) get the clear paste in step (3), add Colla Corii Asini powder, measure its weight, add the sucrose of its weight 25% and the mixture of dextrin, in the mixture of wherein lactose and dextrin, the weight ratio of lactose and dextrin is 3:1; Stir and be heated to 80 ~ 90 DEG C, cross 80 mesh sieves, obtain extract powder with spray dryer, namely subpackage obtains granule.
6. the Chinese medicine according to claim 1,2, is characterized in that: the purposes of described Chinese medicine composition in treatment infantile constipation.
7. the Chinese medicine according to claim 1,2, is characterized in that: the purposes of described Chinese medicine composition in preparation infantile constipation medicine.
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