CN103006994A - Aloe capsule and preparation method thereof - Google Patents
Aloe capsule and preparation method thereof Download PDFInfo
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- CN103006994A CN103006994A CN2012105783047A CN201210578304A CN103006994A CN 103006994 A CN103006994 A CN 103006994A CN 2012105783047 A CN2012105783047 A CN 2012105783047A CN 201210578304 A CN201210578304 A CN 201210578304A CN 103006994 A CN103006994 A CN 103006994A
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Abstract
The invention relates to an aloe capsule and a preparation method thereof. The aloe capsule comprises the following components in percentage by weight: 80 to 95 percent of aloe, and 5 to 20 percent of starch. The preparation method comprises the steps of crushing, drying, mixing, screening and filling into capsules. The product aloe capsule is safe and non-toxic, has remarkable defaecation effect, and does not have dependence after long-time administration.
Description
Technical field
The invention belongs to the capsule field, relate to a kind of bowel relaxing functions capsule, especially a kind of Aloe and preparation method thereof.
Background technology
Modern's diet is too meticulous, and the Plant fiber lacks, and feed meat fat group food is more, has further suppressed the wriggling of intestinal, causes easily constipation.Under normal circumstances, should guarantee once a day defecation, long-term row does not go out just, produces a large amount of toxin and is repeatedly absorbed by intestinal wall, causes easily dim complexion, mottle, acne, pore expansion, pachylosis, halitosis occur.
Relieving constipation product DeGrain in the existing market can not play an effect that takes effect.
Summary of the invention
The object of the invention is to overcome the deficiencies in the prior art part, a kind of aloe capsule and preparation method thereof is provided, the aloe capsule of the present invention preparation contains Aloe and starch, and it has obvious relieving constipation effect, it has that preparation method is simple, the characteristics of instant effect simultaneously.
The present invention realizes that the technical scheme of purpose is as follows:
A kind of aloe capsule, the percentage by weight of composition is as follows:
Aloe: 80%-95%, starch: 5%-20%.
And the percentage by weight of composition is as follows:
Aloe: 87.5%, starch: 12.5%.
And described Aloe, starch meet the " regulation in 2010 editions one one of the Chinese pharmacopoeia.
A kind of preparation method of aloe capsule, the step of method is as follows:
(1) Aloe is pulverized to get fine powder, and with the gained fine powder, 30-60 order stainless steel mesh sieves;
(2) will carry out drying through the fine powder behind the screen cloth, baking temperature 70-100 ℃, 1-2 hour drying time;
(3) starch is carried out drying, baking temperature 70-100 ℃, 1-2 hour drying time;
(4) the Aloe fine powder after will sieving mixes with dried starch, incorporation time 10-30 minute, gets mixed powder 1;
(5) with mixed powder 1,30-60 order stainless steel mesh sieves, and gets mixed powder 2, and mixed powder 2 is carried out encapsulated, arrangement, polishing, bottling, incasement operation.
Advantage of the present invention and beneficial effect are:
1, " Chinese pharmacopoeia record Aloe nature and flavor with return through hardship, cold.Return liver, stomach, large intestine channel.Function with cure mainly: removing heat from the liver, relieving constipation.
2, experimental results show that according to function of health food aloe capsule has bowel relaxing functions.Other have the relieving constipation product and have that effect is strong, the characteristics of instant effect this product at present, really can reach an effect that takes effect.
Description of drawings
Fig. 1 is process chart of the present invention.
The specific embodiment
Below in conjunction with embodiment, a kind of aloe capsule of the present invention and preparation method thereof is further specified, following embodiment is illustrative, is not determinate, can not limit protection scope of the present invention with following embodiment.
Embodiment 1
A kind of aloe capsule, composition following (percentage by weight):
Aloe: 80%, starch: 20%
The preparation method of aloe capsule is as follows:
(1) Aloe is pulverized to get fine powder, gained fine powder 30 order stainless steel meshs are sieved;
(2) will carry out drying through the fine powder behind the screen cloth, 70 ℃ of baking temperatures, 1 hour drying time;
(3) starch is carried out drying, 70 ℃ of baking temperatures, 1 hour drying time;
(4) the Aloe fine powder after will sieving mixes with dried starch, and incorporation time 10 minutes gets mixed powder 1;
(5) mixed powder 1,30 order stainless steel mesh is sieved, get mixed powder 2, mixed powder 2 is carried out encapsulated, arrangement, polishing, bottling, incasement operation.
All carry out at 300,000 clean areas from operation dry, that pulverize, be mixed into inner packing in the present embodiment.
Embodiment 2
A kind of aloe capsule, composition following (percentage by weight):
Aloe: 95%, starch: 5%
The preparation method of aloe capsule is as follows:
(1) Aloe is pulverized to get fine powder, with the gained fine powder, 60 order stainless steel meshs sieve;
(2) will carry out drying through the fine powder behind the screen cloth, 100 ℃ of baking temperatures, 2 hours drying times;
(3) starch is carried out drying, 100 ℃ of baking temperatures, 2 hours drying times;
(4) the Aloe fine powder after will sieving mixes with dried starch, and incorporation time 30 minutes gets mixed powder 1;
(5) mixed powder 1,60 order stainless steel mesh is sieved, get mixed powder 2, mixed powder 2 is carried out encapsulated, arrangement, polishing, bottling, incasement operation.
All carry out at 300,000 clean areas from operation dry, that pulverize, be mixed into inner packing in the present embodiment.
Embodiment 3
A kind of aloe capsule, composition following (percentage by weight):
Aloe: 87.5%, starch: 12.5%
The preparation method of aloe capsule is as follows:
(1) Aloe is pulverized to get fine powder, with the gained fine powder, 40 order stainless steel meshs sieve;
(2) will carry out drying through the fine powder behind the screen cloth, 80 ℃ of baking temperatures, 1.5 hours drying times;
(3) starch is carried out drying, 80 ℃ of baking temperatures, 1.5 hours drying times;
(4) the Aloe fine powder after will sieving mixes with dried starch, and incorporation time 20 minutes gets mixed powder 1;
(5) mixed powder 1,60 order stainless steel mesh is sieved, get mixed powder 2, mixed powder 2 is carried out encapsulated, arrangement, polishing, bottling, incasement operation.
All carry out at 300,000 clean areas from operation dry, that pulverize, be mixed into inner packing in the present embodiment.The compound basis of composition of the present invention
Aloe: this product is the liquid antiperspirant concentrated dry thing of liliaceous plant Aloe vulgaris, and its characteristics are that the content of contained Aloe Radix Et Rhizoma Rhei glycoside is higher than other Aloe kinds.The Aloe nature and flavor are bitter, and are cold.Return liver, stomach, large intestine channel.Major function: removing heat from the liver, relieving constipation.Cure mainly function: constipation, infantile malnutrition, infantile convulsion.The external treatment exudative dermatitis.
Aloe contains more than the 70 swollen compositions such as anthraquinone analog compound, saccharide, aminoacid, lipid, organic acid, mineral, vitamin, Kallidin I enzyme, because the Aloe main component is polysaccharide, anthraquinone, glycoside etc., includes Barbaloin, aloe-emodin, Aloe chrysophanol, anthrol etc. more than 20 and plants composition.These anthraquinone glycosides will be emitted the competence exertion zest discharge functions such as emodin in intestinal tube.Mainly be Aloe Radix Et Rhizoma Rhei glycoside, its bitter principle can promote intestinal peristalsis, adds its some specific physical performances, makes it at immunomodulating, diuresis, loosening bowel to relieve constipation good effect be arranged, and treatment constipation effect is remarkable.Aloe-emodin can promote large intestine position wriggling, brings into play the effect of dropping of its zest, and this stimulation effect of dropping has special efficacy to constipation and hemorrhoid,, particularly to senile constipation, therapeutic effect is apparent in view.But experiment showed, the oral Aloe diarrhea inducing of animal, it rushes down lower Main Function position is large intestine, to the effect of rat small intestine in vitro without the promotion wriggling.
The efficacy test of aloe capsule of the present invention, this zoopery adopt embodiment 1-3 preparation aloe capsule.
One), animal experiment report:
1, materials and methods
1.1 tested material: this aloe capsule content is chocolate brown powder, and the human body recommended amounts is 0.8g (0.0133g/Kg.bw) for each person every day.Tested material is added 2% gelatinized corn starch, and to make the suspension of each dose concentration for subsequent use.
1.2 laboratory animal: have The Fourth Military Medical University's Experimental Animal Center that 100 of healthy adult secondary Kunming kind male white mouses (mobile card word 08-013 number), body weight 18-22 gram are provided.Feedstuff, bedding and padding are originated the same.
1.3 laboratory environment: 24 ℃ of temperature--26 ℃, humidity 45%--55%.The Animal House certificate of competency: the moving word of doctor 08-32 number.
1.4 instrument and reagent: with the mice cage tool of interlayer, dissect with operating scissors, tweezer, meter ruler, electronic balance, plate, glass plate, compound recipe ground phenol promise ester, carbonic ink, normal saline etc.
1.5 dosage is selected: respectively get mice half random packet, carry out respectively the test of mouse small intestine exercise test and defecation, " triumphant a large bell aloe capsule " is designed to high dose (0.4g/Kg.bw), middle dosage (0.2g/Kg.bw), three dosage groups of low dosage (0.1g/Kg.bw), other establishes model control group, and (test of compound recipe ground phenol promise ester intestinal motility is 5.0mg/Kg.bw, defecation test is 10.0mg/Kg.bw) and negative control group capacity gavages such as () 2% gelatinized corn starches, every group of 10 animals, each dosage are equivalent to respectively 30 times of human body recommendation consumption, 15 times and 7.5 times.
1.6 experimental technique: to giving tested material once with the gavage capacity per os gavage of 0.2ml/10g.bw above-mentioned three dosage group every days, negative and model control group all to etc. capacity 2% gelatinized corn starch, continuous gavage is carried out respectively following two tests after 7 days.
1.6.1 intestinal motility test: mice fasting overnight 16 hours, inferior morning, model control group and three dosage elder generation gavages gave compound recipe ground phenol promise ester (5.0mg/Kg.bw), and negative control group is given capacity 2% gelatinized corn starch (the gavage capacity is 0.2ml/10g.bw) such as grade.Each dosage group gives respectively the prepared Chinese ink of corresponding tested material sample after 30 minutes, and feminine gender and model control group are to prepared Chinese ink gavage (capacity is the same).The interval is taken off successively immediately cervical vertebra and is put to death animal and cut open the belly the whole section small intestinal of taking-up stomach to blind section after 25 minutes, measurement pylorus to the distance of ileocecus is the small intestinal total length, measurement, is calculated each treated animal prepared Chinese ink propelling rate and carry out variance analysis after data is transformed to the prepared Chinese ink advance distance from pylorus.
1.6.2 defecation test: with defecation test mice fasting overnight 16 hours, give compound recipe ground phenol promise ester (10.0mg/kg.bw) to model group and each dosage group elder generation gavage inferior morning, and negative control group is given 2% gelatinized corn starch (waiting capacity to be 0.2ml/10g.bw).Each dosage group contains respectively the prepared Chinese ink of corresponding tested material sample after 30 minutes, and feminine gender and model control group are to prepared Chinese ink gavage (capacity is the same).Then every animal is put into separately the band little mouse cage of interlayer (spreading absorbent paper at the bottom of the cage), and normal drinking-water, feed begin respectively every mice of observed and recorded and discharge first melena time and 6 hours defecation gross weight and grain number from filling with prepared Chinese ink.
2. result:
Gavage gives the aloe capsule of mice various dose, tests after continuous 7 days, institute survey indices is compared with the model control group result respectively after determining now to cause Constipation Model success, carries out variance analysis.Each dosage group mice of duration of test is not all found the diarrhoea phenomenon.
2.1 aloe capsule is on the impact of Mouse Weight:
Table 1 aloe capsule is on the impact (intestinal motility test) of Mouse Weight (X ± s)
Table 2 aloe capsule is on the impact (defecation test) of Mouse Weight (X ± s)
Table 1,2 visible each dosage group, model group and negative control group relatively between weight gain difference there are no significant that (p＞0.05) is that aloe capsule has no significant effect Mouse Weight.
2.2 mice causes the foundation of Constipation Model:
The comparison of table 3 negative control group and model control group indices (X ± s)
Obviously reduced than negative mouse small intestine prepared Chinese ink propelling rate by model control group mouse small intestine prepared Chinese ink propelling rate as seen from Table 3, defecation time obviously prolongs first, 6 hours total feces volumes and 6 hours defecation grain numbers obviously reduce, and indices and negative control group difference all have highly significant p＜0.01, so can judge that this mice causes Constipation Model and is successfully established.
2.3 mouse small intestine exercise test:
Table 4 aloe capsule is on the impact of mouse small intestine prepared Chinese ink propelling rate
Each dosage group and model control group compare as seen from Table 4, and mouse small intestine prepared Chinese ink propelling rate all obviously raises, and its height, middle dosage group mouse small intestine prepared Chinese ink propelling rate and model control group comparing difference all have significance p＜0.01.
2.4 mice defecation test
Table 5 aloe capsule is on the first impact of defecation time of mice
F＝3.660 P＝0.021
Table 6 aloe capsule is on the impact of 6 hours total feces volumes of mice and defecation grain number
F＝3.805 P＝0.018 F＝3.093 P＝0.039
By table 5,6 as seen, high, middle dosage group mice first defecation time and model control group comparing difference all has significance p＜0.05, and high dose group mice 6 hours defecation grains number and model control group comparing difference have significance p＜0.05.6 hours defecation total amounts of high dose group mice and model control group relatively have highly significant p＜0.01.
3 brief summaries
3.1 (mice) causes Constipation Model and is successfully established
(3.2 mice) intestinal motility result of the test: each dosage group mouse small intestine prepared Chinese ink propelling rate of aloe capsule is apparently higher than model control group, and height, middle dosage group and its difference all have significance p＜0.05.
(3.3 mice) defecation result of the test: aloe capsule is high, middle dosage group can obviously shorten the first defecation time that causes mice with constipation and with the model control group comparing difference significance p＜0.05 is arranged.High dose group can obviously increase cause mice with constipation stool and defecation total amount and and model control group between difference significance p＜0.05 is arranged, p＜0.01.
The above results shows: this mouse small intestine prepared Chinese ink propulsion trial of aloe capsule and the test of mice defecation are positive findings, so can judge that aloe capsule has bowel relaxing functions.
Claims (7)
1. aloe capsule, it is characterized in that: the percentage by weight of composition is as follows:
Aloe: 80%-95%, starch: 5%-20%.
2. aloe capsule according to claim 1, it is characterized in that: the percentage by weight of composition is as follows:
Aloe: 87.5%, starch: 12.5%.
3. described aloe capsule one of according to claim 1-2 is characterized in that: described Aloe, starch meet the " regulation in 2010 editions one one of the Chinese pharmacopoeia.
4. preparation method such as one of claim 1-3 described aloe capsule, it is characterized in that: the step of method is as follows:
(1) Aloe is pulverized to get fine powder, with the gained fine powder, 30-60 order stainless steel mesh sieves;
(2) will carry out drying through the fine powder behind the screen cloth, baking temperature 70-100 ℃, 1-2 hour drying time;
(3) starch is carried out drying, baking temperature 70-100 ℃, 1-2 hour drying time;
(4) the Aloe fine powder after will sieving mixes with dried starch, incorporation time 10-30 minute, gets mixed powder 1;
(5) with mixed powder 1,30-60 order stainless steel mesh sieves, and gets mixed powder 2, and mixed powder 2 is carried out encapsulated, arrangement, polishing, bottling, incasement operation.
5. the preparation method of aloe capsule according to claim 4 is characterized in that: described Aloe and starch are dried to moisture less than or equal to 7%.
6. the preparation method of aloe capsule according to claim 4, it is characterized in that: described step (1) Aloe powder flour, 40 order stainless steel meshs sieve.
7. the preparation method of aloe capsule according to claim 4, it is characterized in that: described step (5) mixed powder 1,60 order stainless steel mesh sieves.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012105783047A CN103006994A (en) | 2012-12-26 | 2012-12-26 | Aloe capsule and preparation method thereof |
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| CN2012105783047A CN103006994A (en) | 2012-12-26 | 2012-12-26 | Aloe capsule and preparation method thereof |
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| CN103006994A true CN103006994A (en) | 2013-04-03 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105213738A (en) * | 2015-11-11 | 2016-01-06 | 青岛麦瑞特医药技术有限公司 | A kind of Chinese medicine being used for the treatment of infantile constipation and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101099816A (en) * | 2007-07-04 | 2008-01-09 | 余祥彬 | Technology for producing constipation-relieving capsule |
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- 2012-12-26 CN CN2012105783047A patent/CN103006994A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101099816A (en) * | 2007-07-04 | 2008-01-09 | 余祥彬 | Technology for producing constipation-relieving capsule |
Non-Patent Citations (1)
| Title |
|---|
| 张裕民等: "芦荟(颗粒) 胶囊制备工艺研究", 《湖南中医药导报》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105213738A (en) * | 2015-11-11 | 2016-01-06 | 青岛麦瑞特医药技术有限公司 | A kind of Chinese medicine being used for the treatment of infantile constipation and preparation method thereof |
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Application publication date: 20130403 |