CN104547341A - Aloe capsule and preparation method thereof - Google Patents
Aloe capsule and preparation method thereof Download PDFInfo
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- CN104547341A CN104547341A CN201410844814.3A CN201410844814A CN104547341A CN 104547341 A CN104547341 A CN 104547341A CN 201410844814 A CN201410844814 A CN 201410844814A CN 104547341 A CN104547341 A CN 104547341A
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Abstract
The invention relates to an aloe capsule and a preparation method thereof. The aloe capsule comprises the following components in percentage by weight: 80-95% of aloes and 5-20% of starch. The preparation method comprises the following steps: performing grinding, drying, mixing, screening and capsule loading to obtain the aloe capsule. The aloe capsule is safe, nontoxic, remarkable in catharsis effect and free of dependence after being taken for a long term.
Description
Technical field
The invention belongs to capsule field, relate to a kind of bowel relaxing functions capsule, especially a kind of Aloe and preparation method thereof.
Background technology
Modern's diet is too meticulous, and Plant fiber lacks, and feed meat fat group food is more, further suppress the wriggling of intestinal, easily causes constipation.Under normal circumstances, should ensure defecation once a day, long-term row does not go out just, produces a large amount of toxin and is repeatedly absorbed by intestinal wall, easily cause dim complexion, occurs the expansion of mottle, acne, pore, pachylosis, halitosis.
Relieving constipation product DeGrain in existing market, can not play an effect taken effect.
Summary of the invention
The object of the invention is to overcome the deficiencies in the prior art part, a kind of aloe capsule and preparation method thereof is provided, aloe capsule prepared by the present invention contains Aloe and starch, and it has obvious relieving constipation effect, simultaneously it has that preparation method is simple, the feature of instant effect.
The technical scheme that the present invention realizes object is as follows:
A kind of aloe capsule, the percentage by weight of composition is as follows:
And the percentage by weight of composition is as follows:
Aloe: 87.5%, starch: 12.5%.
And described Aloe, starch meet the regulation in " Chinese Pharmacopoeia " 2010 editions.
A preparation method for aloe capsule, the step of method is as follows:
(1) Aloe is pulverized to obtain fine powder, gained fine powder 30-60 order stainless steel mesh is sieved;
(2) the fine powder after screen cloth is carried out drying, baking temperature 70-100 DEG C, drying time 1-2 hour;
(3) starch is carried out drying, baking temperature 70-100 DEG C, drying time 1-2 hour;
aloe fine powder after sieving is mixed with dried starch, incorporation time 10-30 minute, obtain mixed powder 1;
mixed powder 1,30-60 order stainless steel mesh is sieved, obtains mixed powder 2, mixed powder 2 is carried out encapsulated, arrangement, polishing, bottling, incasement operation.
Advantage of the present invention and beneficial effect are:
1, " Chinese Pharmacopoeia " record Aloe nature and flavor with return through: bitter, cold.Return liver, stomach, large intestine channel.Function with cure mainly: removing heat from the liver, relieving constipation.
2, prove that aloe capsule has bowel relaxing functions according to function of health food experiment.Other have relieving constipation product and have that effect is strong, the feature of instant effect this product comparatively at present, really can reach an effect taken effect.
Detailed description of the invention
Below in conjunction with embodiment, further illustrate a kind of aloe capsule of the present invention and preparation method thereof, following embodiment is illustrative, is not determinate, can not limit protection scope of the present invention with following embodiment.
Embodiment 1
A kind of aloe capsule, composition following (percentage by weight):
Aloe: 80%, starch: 20%
The preparation method of aloe capsule is as follows:
(1) Aloe is pulverized to obtain fine powder, gained fine powder 30 order stainless steel mesh is sieved;
(2) the fine powder after screen cloth is carried out drying, baking temperature 70 DEG C, 1 hour drying time;
(3) starch is carried out drying, baking temperature 70 DEG C, 1 hour drying time;
mixed with dried starch by Aloe fine powder after sieving, incorporation time 10 minutes, obtains mixed powder 1;
by mixed powder 1,30 order stainless steel meshs sieve, and obtain mixed powder 2, mixed powder 2 are carried out encapsulated, arrangement, polishing, bottling, incasement operation.
All carry out in 300,000 clean areas from operation that is dry, that pulverize, be mixed into inner packing in the present embodiment.
Embodiment 2
A kind of aloe capsule, composition following (percentage by weight):
Aloe: 95%, starch: 5%
The preparation method of aloe capsule is as follows:
aloe is pulverized to obtain fine powder, and by gained fine powder, 60 order stainless steel meshs sieve;
fine powder after screen cloth is carried out drying, baking temperature 100 DEG C, 2 hours drying times;
starch is carried out drying, baking temperature 100 DEG C, 2 hours drying times;
mixed with dried starch by Aloe fine powder after sieving, incorporation time 30 minutes, obtains mixed powder 1;
by mixed powder 1,60 order stainless steel meshs sieve, and obtain mixed powder 2, mixed powder 2 are carried out encapsulated, arrangement, polishing, bottling, incasement operation.
All carry out in 300,000 clean areas from operation that is dry, that pulverize, be mixed into inner packing in the present embodiment.
Embodiment 3
A kind of aloe capsule, composition following (percentage by weight):
Aloe: 87.5%, starch: 12.5%
The preparation method of aloe capsule is as follows:
aloe is pulverized to obtain fine powder, and by gained fine powder, 40 order stainless steel meshs sieve;
fine powder after screen cloth is carried out drying, baking temperature 80 DEG C, 1.5 hours drying times;
starch is carried out drying, baking temperature 80 DEG C, 1.5 hours drying times;
mixed with dried starch by Aloe fine powder after sieving, incorporation time 20 minutes, obtains mixed powder 1;
by mixed powder 1,60 order stainless steel meshs sieve, and obtain mixed powder 2, mixed powder 2 are carried out encapsulated, arrangement, polishing, bottling, incasement operation.
All carry out in 300,000 clean areas from operation that is dry, that pulverize, be mixed into inner packing in the present embodiment.
The compound basis of present component
Aloe: this product is the liquid antiperspirant concentrated dry thing of liliaceous plant Aloe vulgaris, its feature is that the content of contained Aloe Radix Et Rhizoma Rhei glycoside is higher than other Aloe kinds.Aloe nature and flavor are bitter, cold.Return liver, stomach, large intestine channel.Major function: removing heat from the liver, relieving constipation.Cure mainly function: constipation, infantile malnutrition, infantile convulsion.External treatment exudative dermatitis.
Aloe contains the swollen composition of anthraquinone analog compound, saccharide, aminoacid, lipid, organic acid, mineral, vitamin, Kallidin I enzyme etc. more than 70, because Aloe main component is polysaccharide, anthraquinone, glycoside etc., include Barbaloin, aloe-emodin, Aloe chrysophanol, anthrol etc. more than 20 and plant composition.These anthraquinone glycosides will release the competence exertion zest discharge functions such as emodin in intestinal tube.Mainly Aloe Radix Et Rhizoma Rhei glycoside, its bitter principle can promote intestinal peristalsis, adds its some specific physical performances, makes it on immunomodulating, diuresis, loosening bowel to relieve constipation, have good effect, and treatment anti-constipation effect is remarkable.Aloe-emodin can promote to wriggle in large intestine position, plays the effect of dropping of its zest, and this stimulation effect of dropping has special efficacy to constipation and hemorrhoid, particularly to senile constipation, therapeutic effect is obvious.Experiment proves, the oral Aloe of animal can diarrhea inducing, and it rushes down lower Main Function position is large intestine, to rat small intestine in vitro without the effect promoting to wriggle.
The efficacy test of aloe capsule of the present invention, this zoopery adopt embodiment 1-3 prepare aloe capsule.
One), animal experiment report:
1, materials and methods
1. 1 tested material: this aloe capsule content is chocolate brown powder, human body recommended amounts is 0.8g(0.0133g/Kg.bw for each person every day).Tested material being added 2% gelatinized corn starch, to make the suspension of each dose concentration for subsequent use.
1. 2 laboratory animals: have The Fourth Military Medical University's Experimental Animal Center to provide healthy adult secondary Kunming kind male white mouse 100 (mobile card No. 08-013, word), body weight 18-22 grams.Feedstuff, bedding and padding source is the same.
1.3 laboratory environments: temperature 24 DEG C--26 DEG C, humidity 45%--55%.The Animal House certificate of competency: dynamic No. 08-32, the word of doctor.
1.4 instruments and reagent: be with the little mouse cage tool of interlayer, dissection operating scissors, tweezer, meter ruler, electronic balance, plate, glass plate, compound recipe ground phenol promise ester, carbonic ink, normal saline etc.
1.5 dosage choice: respectively get mice half random packet, carry out mouse small intestine exercise test and defecation test respectively, " triumphant a large bell aloe capsule " is designed to high dose (0.4g/Kg.bw), middle dosage (0.2g/Kg.bw), low dosage (0.1g/Kg.bw) three dosage groups, separately set model control group (test of compound recipe ground phenol promise ester intestinal motility be 5.0mg/Kg.bw, defecation test be 10.0mg/Kg.bw) and negative control group capacity gavages such as () 2% gelatinized corn starches, often organize 10 animals, each dosage is equivalent to 30 times, 15 times and 7.5 times of human body recommendation consumption respectively.
1.6 experimental techniques: give tested material once with the gavage capacity per os gavage of 0.2ml/10g.bw every day to above-mentioned three dosage groups, negative and model control group all to etc. capacity 2% gelatinized corn starch, continuous gavage carries out following two tests respectively after 7 days.
1.6.1 intestinal motility test: mice fasting overnight 16 hours, secondary morning model control group and three first gavages of dosage give compound recipe ground phenol promise ester (5.0mg/Kg.bw), negative control group is given and is waited capacity 2% gelatinized corn starch (gavage capacity is 0.2ml/10g.bw).After 30 minutes, each dosage component does not give the prepared Chinese ink of corresponding tested material sample, and feminine gender and model control group are to prepared Chinese ink gavage (capacity is the same).Interval takes off cervical vertebra immediately successively and puts to death animal and the whole section small intestinal of taking-up stomach to blind portion of cutting open the belly after 25 minutes, measurement pylorus is small intestinal total length to the distance of ileocecus, measurement to prepared Chinese ink advance distance from pylorus, calculates each treated animal ink progradation and carry out variance analysis after data transformations.
1.6.2 defecation test: by fasting overnight for defecation test mice 16 hours, secondary morning gives compound recipe ground phenol promise ester (10.0mg/kg.bw) to model group and the first gavage of each dosage group, and negative control group gives 2% gelatinized corn starch (waiting capacity to be 0.2ml/10g.bw).After 30 minutes, each dosage component does not give the prepared Chinese ink containing corresponding tested material sample, and feminine gender and model control group are to prepared Chinese ink gavage (capacity is the same).Then every animal puts into separately the band little mouse cage of interlayer (spreading absorbent paper at the bottom of cage), normal water, feed, and from filling prepared Chinese ink, observed and recorded every mice discharges melena time and 6 hours defecation gross weight and grain number first respectively.
2. result:
Gavage gives the aloe capsule of mice various dose, tests after continuous 7 days, to determine surveyed indices now to cause after Constipation Model success respectively compared with model control group result, carries out variance analysis.Duration of test each dosage group mice does not all find phenomenon of suffering from diarrhoea.
2.1 aloe capsules are on the impact of Mouse Weight:
Table 1 aloe capsule is on the impact (intestinal motility test) (X ± s) of Mouse Weight
Table 2 aloe capsule is on the impact (defecation test) (X ± s) of Mouse Weight
Table 1,2 visible each dosage groups, model group compare difference between weight gain there are no significant that (p > 0.05) i.e. aloe capsule has no significant effect Mouse Weight with negative control group.
2.2 mices cause the foundation of Constipation Model:
The comparison (X ± s) of table 3 negative control group and model control group indices
Obviously reduced than negative mice small intestinal ink progradation by the visible model control group mouse small intestine ink progradation of table 3, defecation time obviously extends first, 6 hours total feces volumes and 6 hours defecation grain numbers obviously reduce, and indices and negative control group difference all have highly significant p < 0.01, therefore can judge that this mice causes Constipation Model and is successfully established.
2.3 mouse small intestine exercise tests:
Table 4 aloe capsule is on the impact of mouse small intestine ink progradation
The visible each dosage group of table 4 compares with model control group, and mouse small intestine ink progradation all obviously raises, and its height, middle dosage group mouse small intestine ink progradation and model control group comparing difference all have significance p < 0.01.
2.4 mice defecation tests
Table 5 aloe capsule is on the impact of mice defecation time first
F=3.660 P=0.021
Table 6 aloe capsule is on the impact of mice 6 hours total feces volumes and defecation grain number
F=3.805 P=0.018 F=3.093 P=0.039
From table 5,6, high, middle dosage group mice first defecation time and model control group comparing difference all has significance p < 0.05, and high dose group mice 6 hours defecation grain numbers and model control group comparing difference have significance p < 0.05.High dose group mice 6 hours defecation total amounts compare with model control group highly significant p < 0.01.
3 brief summaries
3.1(mice) cause Constipation Model and be successfully established
3.2(mice) intestinal motility result of the test: aloe capsule each dosage group mouse small intestine ink progradation is apparently higher than model control group, and height, middle dosage group and its difference all have significance p < 0.05.
3.3(mice) defecation result of the test: high, the middle dosage group of aloe capsule obviously can shorten the defecation time first that causes mice with constipation and have significance p < 0.05 with model control group comparing difference.High dose group obviously can increase and causes mice with constipation stool and defecation total amount and have significance p < 0.05, p < 0.01 with model comparison group difference.
The above results shows: this mouse small intestine prepared Chinese ink propulsion trial of aloe capsule and mice defecation are tested and be positive findings, therefore can judge that aloe capsule has bowel relaxing functions.
Claims (7)
1. an aloe capsule, is characterized in that: the percentage by weight of composition is as follows:
Aloe: 80%-95%, starch: 5%-20%.
2. aloe capsule according to claim 1, is characterized in that: the percentage by weight of composition is as follows:
Aloe: 87.5%, starch: 12.5%.
3. according to the aloe capsule one of claim 1-2 Suo Shu, it is characterized in that: described Aloe, starch meet the regulation in " Chinese Pharmacopoeia " 2010 editions.
4. a preparation method for the aloe capsule as described in one of claim 1-3, is characterized in that: the step of method is as follows:
(1) Aloe is pulverized to obtain fine powder, gained fine powder 30-60 order stainless steel mesh is sieved;
(2) the fine powder after screen cloth is carried out drying, baking temperature 70-100 DEG C, drying time 1-2 hour;
(3) starch is carried out drying, baking temperature 70-100 DEG C, drying time 1-2 hour;
aloe fine powder after sieving is mixed with dried starch, incorporation time 10-30 minute, obtain mixed powder 1;
mixed powder 1,30-60 order stainless steel mesh is sieved, obtains mixed powder 2, mixed powder 2 is carried out encapsulated, arrangement, polishing, bottling, incasement operation.
5. the preparation method of aloe capsule according to claim 4, is characterized in that: described Aloe and starch are dried to moisture and are less than or equal to 7%.
6. the preparation method of aloe capsule according to claim 4, is characterized in that: described step is Aloe powder flour (1), and 40 order stainless steel meshs sieve.
7. the preparation method of aloe capsule according to claim 4, is characterized in that: described step
mixed powder 1,60 order stainless steel meshs sieve.
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| CN201410844814.3A CN104547341A (en) | 2014-12-31 | 2014-12-31 | Aloe capsule and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106136243A (en) * | 2016-08-26 | 2016-11-23 | 李仁宝 | A kind of Sargassum extract health care soft capsule |
| CN107801997A (en) * | 2017-11-30 | 2018-03-16 | 天津活力达生物科技有限公司 | A kind of aloe capsule with function of relaxing bowel and preparation method thereof |
-
2014
- 2014-12-31 CN CN201410844814.3A patent/CN104547341A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106136243A (en) * | 2016-08-26 | 2016-11-23 | 李仁宝 | A kind of Sargassum extract health care soft capsule |
| CN107801997A (en) * | 2017-11-30 | 2018-03-16 | 天津活力达生物科技有限公司 | A kind of aloe capsule with function of relaxing bowel and preparation method thereof |
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Application publication date: 20150429 |
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